Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_001746795Cyc: Piscirickettsia salmonis AY3800B Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari

lipid II (meso diaminopimelate 2+ phosphate Mg containing) Co 2+

RS00065 RS15145 RS08855 RS08330 RS08105 RS07905 RS07160 RS06550 RS14225 RS05365 RS05005 FliQ RS13580 RS04095 RS03695 RS03315 RS03070 RS12345 TypA RS12050 RS01480 RS11100 RS11015 RS01215 RS10860 RS10620 RS08655 MurJ RS10415 RS10330 RS00450 RS10075 IcmP RS09985 RS09920 ApaG RS09870 RS00235 RS10015 RS10055 RS10080 RS10195 RS10405 RS10445 RS10515 RS10565 RS01040 RS01160 RS10950 FtsW RS01465 RS01705 RS02185 TolR RS02840 RS03190 RS03595 RS03945 RS04280 RS04650 RS13705 RS05285 RS05680 RS06165 RS06945 RS07480 RS10305 RS08640 MlaE RS09600

lipid II (meso Mg 2+ diaminopimelate phosphate Co 2+ containing)

RS01875 RS09935 Macromolecule Modification glutaminyl-tRNA gln Aminoacyl-tRNA Charging 6 α L-alanyl-γ-D- tRNA-uridine 2-thiolation ATP biosynthesis Carbohydrate Degradation N -(3-methylbut- a nascent peptidoglycan UDP-N-acetyl- -D- a nascent UDP-N-acetyl- phosphoenol a nucleoside an L-cysteinyl- biosynthesis via transamidation a sulfurated γ a lipid II H O γ 2-en-1-yl)- with (L-alanyl- -D-glutamyl- muramoyl-L-alanyl- peptidoglycan glutamyl-meso- UDP-N-acetyl- α-D-muramoyl- 2 RNA -L-glutamyl- gly Cys and selenation (bacteria) [sulfur carrier] GTP dGDP pyruvate triphosphate ATP roseoflavin [tRNA ] RS02295 RS09970 Secondary Metabolite Biosynthesis adenosine 37 meso-2,6-diaminopimeloyl-D- γ-D-glutamyl-meso- (meso-DAP diaminopimelate α-D-muramate L-alanyl-γ-D- D-alanine ADP D-galactose degradation I (Leloir pathway) D-alanyl-D-alanine 5'-phosphate glu N-acetylneuraminate and in tRNA alanyl-D-alanine) pentapeptide 2,6-diaminopimelate containing) glutamyl-meso-2,6- cys F0F1 ATP synthase: penicillin- preQ biosynthesis N-acetylmannosamine UDP-N- diaminopimeloyl- DNA- glutathione aminoacyl- 0 AVM72_RS13010 atpB β-D-galactopyranose binding ribosome myo-inositol degradation I tRNA (N6-isopentenyl D-alanyl-D-alanine directed RNA bifunctional tRNA IscS subfamily atpE AVM72_RS13025 penicillin-binding UDP-N- endolytic acetylmuramate:L- protein biogenesis pyruvate synthase: biosynthesis N-acetylneuraminate adenosine(37)-C2)- polymerase riboflavin hydrolase: TolB RS10020 cysteine AVM72_RS13030 protein 2: mrdA acetylmuramoyl- transglycosylase alanyl-gamma-D- 2: mrdA GTPase kinase: pyk gshB GTP D-glucopyranose N-acetylneuraminate methylthiotransferase subunit kinase/FAD pth gln an L-glutamyl- desulfurase: AVM72_RS13035 atpG D-alanyl-D-alanine tripeptide--D-alanyl- MltG: mltG glutamyl- meso- penicillin- D-alanyl-D-alanine Der: der glutathione 6-phosphate lyase: MiaB: miaB omega: rpoZ synthetase: [tRNA Gln ] AVM72_RS02310 carboxypeptidase/ D- alanine ligase: lytic murein diaminopimelate binding [+ 3 isozymes] synthase: GTP cyclohydrolase I atpD AVM72_RS13050 α carboxypeptidase/ + + -D-galactopyranose AVM72_RS14570 succinate AVM72_RS12905 ligase: mpl [+ 3 isozymes] ribF H RS04195 H Asp-tRNA(Asn) FolE2: AVM72_RS07325 cysteine N-acetyl-D- D-alanyl-D-alanine- transglycosylase protein D-alanyl-D-alanine- pyruvate gshB Asp-tRNA(Asn) dehydrogenase, Cys /Glu-tRNA(Gln) 7,8-dihydroneopterin 3'-triphosphate ATP mannosamine endopeptidase: dacB B: mltB 2: mrdA dGTP cys a tRNA RS04215 RS10085 /Glu-tRNA(Gln) desulfurase: galactokinase: endopeptidase: dacB H + amidotransferase: Ins(3)P hydrophobic α phosphate roseoflavin N-acetylmannosamine UDP-N-acetyl- -D- UDP-N-acetyl- GDP + + amidotransferase: AVM72_RS04815 AVM72_RS01485 membrane anchor D-alanyl-D-alanine RNA adenine H RS05225 H gatB gatA gatC 6-carboxytetrahydropterin an [L-cysteine kinase: muramoyl-L-alanyl- α-D-muramoyl- norophthalmate gatB gatA gatC inositol protein: sdhD a nascent peptidoglycan a mature a nascent carboxypeptidase/ a N- dinucleotide [+ 5 isozymes] synthase: AVM72_RS00325 desulfurase]-S- AVM72_RS14560 γ γ-D-glutamyl-meso- L-alanyl-γ-D- a 5-phosphooxy- monophosphatase: α-D-galactose 1-phosphate UDP-α-D-glucose with (L-alanyl- -D-glutamyl- D-ala peptidoglycan peptidoglycan D-alanyl-D-alanine- D-ala acetylglucosamine- 6-carboxytetrahydropterin sulfanyl-L-cysteine N-acetyl-D- 6 2,6-diaminopimeloyl- glutamyl-meso-2,6- RS13570 RS10100 L-glutamyl- AVM72_RS02300 N -(3-methylbut- meso-2,6-diaminopimeloyl- with (L-alanyl- (meso-DAP endopeptidase: dacB -N-acetylmuramyl- + F0F1 ATP + ammonium an unsulfurated H H [tRNA Gln ] synthase: AVM72_RS11575 mannosamine 5'-deoxyadenosine 2-en-1-yl)-2- met D-alanine) tetrapeptide D-alanyl-D-alanine γ-D-glutamyl- containing) with diaminopimelate (tetrapeptide) synthase myo-inositol 6-phosphate [sulfur carrier] GlcNAc terminus 6-carboxy-5,6,7,8-tetrahydropterin (methylsulfanyl) meso-2,6- UDP-N- pyrophosphoryl- putative N- 37 Asp-tRNA(Asn) a [TusA sulfur- adenosine diaminopimeloyl- D-ala acetylmuramoyl- undecaprenol acetylmannosamine- /Glu-tRNA(Gln) carrier protein]-S- in tRNA D-alanine) L-alanyl-γ-D- RS00095 RS04955 RS00660 7-carboxy-7-deazaguanine 6-phosphate amidotransferase: sulfanyl-L-cysteine tetrapeptide glutamyl-meso-2,6- synthase QueE: queE 2-epimerase: gatB gatA gatC sulfurtransferase diaminopimeloyl- RS09795 AVM72_RS14555 7-carboxy-7-deazaguanine complex: tusD D-alanine tusC TusB N-acetyl-D- an L-glutaminyl- tRNA charging glucosamine RS05750 RS10465 Gln 7-cyano-7-deazaguanine a [TusD sulfur- RS09620 [tRNA ] γ α synthase: AVM72_RS02645 carrier protein]-S- 6-phosphate a nascent peptidoglycan a peptidoglycan a peptidoglycan dimer (meso N-acetyl-muramoyl-(L- L-alanyl- -D- a [bis(guanylyl UDP-N-acetyl- phosphoenol an [apo BCAA N-acetyl- - menadione NADH H + a [glutamine- RS09660 sulfanyl-L-cysteine α with (L-alanyl-γ-D- with (L-alanyl-γ-D- -diaminopimelate containing) alanyl-γ-D-glutamyl-L- glutamyl-meso-2,6- molybdopterin) cys α-D-muramoyl- D-glt dehydrogenase ala UDP-N-acetyl- D-muramoyl- ser a tRNA sec glu a tRNA glu 7-cyano-7-deazaguanine 2-deoxy- -D-ribose 1- ATP dADP pyruvate synthetase]- 6 α synthase QueC: queC TusD:TusE phosphate degradation glutamyl-meso-2,6- glutamyl-meso-2,6- lysyl-D-alanyl-D-alanine) diaminopimeloyl- UDP-N-acetyl- cofactor L-alanine E2 protein] N -D-muramate L-alanine(1-) sulfurtransferase: diaminopimeloyl- diaminopimeloyl-D- D-alanine α-D-muramate chaperone]- L-tyrosine -dihydrolipoyl- ser Ala asp α penicillin-binding RS05755 RS01630 ser a tRNA a tRNA ala tRNA asp preQ AVM72_RS08485 2-deoxy- -D- NADH-quinone dihydrolipoyl RS09540 glutamate- elongator 0 D-alanyl-D-alanine) alanine) tetrapeptide penicillin-binding L-cysteine L-lysine 1,6-anhydro-N- lys a tRNA Lys tyr a tRNA Tyr his a tRNA His pro a tRNA Pro cys a tRNA Cys met initiator tRNA Met met leu a tRNA Leu arg a tRNA Arg trp a tRNA Trp asn tRNA Asn thr a tRNA Thr ile a tRNA Ile gly a tRNA Gly phe a tRNA Phe a [TusE sulfur UDP-glucose-- ribose 1-phosphate protein 2: mrdA oxidoreductase: UDP-N- dehydrogenase: UDP-N- serine- -tRNA tRNA Met UDP-glucose pentapeptide protein 2: mrdA bifunctional [glutamate- acetylmuramyl- RS09545 Val hexose-1-phosphate D-alanyl-D-alanine UDP-N- acetylmuramoyl- pyruvate acetylmuramate- -tRNA val a tRNA 34 carrier protein]-S 4-epimerase phosphopentomutase: nuoN nuoK lpdA ligase: gltX gln Gln a uridine in tRNA acetylmuramate:L- -ammonia ligase]- L-alanine-- kinase: pyk -L-alanine L-alanine ligase: serine- alanine- aspartate- a tRNA -sulfanylcysteine uridylyltransferase: GalE: galE carboxypeptidase/ D-alanyl-D-alanine AVM72_RS11705 cysteine dihydrolipoyl Metabolic Regulator AVM72_RS03725 alanyl-gamma-D- adenylyl-L-tyrosine D-glutamate ligase: murC amidase serS lysine- tyrosine-- histidine- glutamate-- proline-- -tRNA -tRNA -tRNA cysteine-- methionine- methionine- leucine-- arginine-- tryptophan- asparagine- threonine- isoleucine- glycine--tRNA phenylalanine- AVM72_RS01490 penicillin-binding D-alanyl-D-alanine- carboxypeptidase/ nuoI nuoH desulfurase: dehydrogenase: RS06705 RS12280 Biosynthesis α-D-glucopyranose 2-deoxy-D-ribose glutamyl- meso- phosphorylase/ ligase: murD an [apo BCAA AmpD: ampD -tRNA tRNA ligase: -tRNA tRNA ligase: tRNA ligase: valine--tRNA ligase: ligase: ligase: ligase: tRNA ligase: -tRNA -tRNA tRNA ligase: tRNA ligase: -tRNA -tRNA -tRNA -tRNA ligase: glyQ -tRNA ligase: tRNA 2- UDP-α-D-galactose protein 2: endopeptidase: dacB D-alanyl-D-alanine- AVM72_RS11720 AVM72_RS04815 AVM72_RS04655 RS09385 1-phosphate 5-phosphate diaminopimelate [glutamate-- dehydrogenase RS09335 ligase: lysS AVM72_RS00285 ligase: hisS AVM72_RS05810 AVM72_RS02545 AVM72_RS03075 serS alaS aspS AVM72_RS05805 ligase: metG ligase: metG AVM72_RS11000 AVM72_RS11060 ligase: trpS ligase: asnS ligase: thrS ligase: ileS AVM72_RS12570 pheS pheT ppGpp metabolism thiouridine(34) AVM72_RS12915 endopeptidase: dacB nuoF IscS subfamily pyruvate UDP-N-acetyl- ligase: mpl ammonia-ligase] dATP E2 protein] N 6 α N-acetyl-D- an L-seryl- synthase [+ 3 isozymes] a peptidoglycan with AVM72_RS11735 cysteine UDP-N-acetyl- -D-muramoyl- sec an L-methionyl- phosphomannomutase/ deoxyribose- adenylyltransferase: -lipoyl-L-lysine [tRNA ] an L-lysyl- an L-tyrosyl- an L-histidyl- an L-glutamyl- an L-prolyl- an L-valyl- an L-seryl- an L-alanyl- an L-aspartyl- an L-cysteinyl- an L-methionyl- an L-leucyl- an L-arginyl- an L-tryptophanyl- an L-asparaginyl- an L-threonyl- an L-isoleucyl- an L-phenylalanyl- an L-glutaminyl- MnmA: mnmA D,D cross-links (meso- D-ala N-acetyl-muramoyl-(L- AVM72_RS11740 desulfurase: α-D-muramoyl-L- L-alanine ala muramate [elongator a glycyl-[tRNA Gly ] pppGpp phosphoglucomutase: phosphate glnE RS06725 RS02595 Lys Tyr His Glu Pro Val ser Ala asp Cys Met Leu Arg Trp Asn Thr Ile Phe Gln alanyl-γ-D-glutamyl- UDP-N-acetylmuramoyl- AVM72_RS02310 alanyl-D-glutamate [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] Met [initiator tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] bifunctional (p)ppGpp AVM72_RS11965 a nascent peptidoglycan diaminopimelate containing) D-ala tRNA ] 34 aldolase: γ RS08920 synthetase/guanosine- a 2-thiouridine with D,D cross-links D-ala L-lysyl-D-alanine) L-alanyl- -D- RS08410 deoC a [glutamine 3',5'-bis(diphosphate) 3'- in tRNA D-glucopyranose 6-phosphate (meso-diaminopimelate glutamyl-meso-2,6- NAD + menadiol a [bis(guanylyl synthetase]-O pyrophosphohydrolase: tRNA uridine-5- containing) diaminopimeloyl- ala molybdopterin) guanosine 3'-diphosphate D-glyceraldehyde 4 -(5'-adenylyl) FlgC RS16910 AVM72_RS08080 carboxymethylaminomethyl(34) acetaldehyde D-alanine cofactor Amino Acid Biosynthesis 5'-triphosphate 3'- 3-phosphate -L-tyrosine GTP diphosphokinase: relA diphosphatase: synthesis GTPase MnmE: mnmE chaperone]-S- RS08645 RS08650 AVM72_RS08080 tRNA uridine-5- sulfanyl-L-cysteine L-lysine biosynthesis I carboxymethylaminomethyl(34) L-tryptophan biosynthesis L-isoleucine superpathway of L-serine L-glutamine L-homoserine synthesis enzyme MnmG: mnmG FlgB RS02885 Fatty Acid and Lipid Biosynthesis biosynthesis I and glycine biosynthesis I biosynthesis I acetyl-CoA a mature peptidoglycan a peptidoglycan GlcNAc-1,6- a peptidoglycan Nα,Nε-diacetyl-lysyl- a mature a [glutamine (S)-1-pyrroline- Amine and Polyamine biosynthesis a D-tyrosyl- oleoyl-CoA H O an ADP-sugar an L-asparaginyl- asp a 5-carboxymethylaminomethyl- (meso-diaminopimelate dimer (E. faeciums) anhMurNAc-L-Ala- dimer (S. aureus) peptidoglycan synthetase]-O Tyr 2 5-carboxylate Asn a protein (from threonine) D-alanyl-D-alanine (n) [tRNA ] [tRNA ] RS08345 RS08405 Biosynthesis gln 3-phospho- GTP ppGpp 34 γ 4 palmitate biosynthesis bifunctional chorismate 2-thiouridine in tRNA containing) -D-Glu-DAP-D-Ala (meso-DAP -(5'-adenylyl) bifunctional ATP- gondoate biosynthesis acyl-CoA hydrolysis thr asp D-glycerate glu -L-tyrosine proline (type II fatty acid synthase) octanoyl-[acyl-carrier spermidine biosynthesis III aspartate kinase/ phosphoglycerate glutamate- FAD-dependent 5- penicillin-binding penicillin- containing) ADP dependent (anaerobic) bifunctional penicillin- acyl-CoA dehydrogenase/L- RS07010 FliD protein] biosynthesis homoserine threonine/serine dehydrogenase: serA -ammonia carboxymethylaminomethyl- endolytic protein 2: mrdA 1,6-anhydro-N- binding D-tyrosyl-tRNA(Tyr) compounds aminoacyl- Clp protease a 2,3,4-saturated anthranilate aspartate kinase/ binding thioesterase: glutamate gamma- (mitochondria, yeast) dehydrogenase dehydratase: 3-phosphooxypyruvate ligase: glnA 2-thiouridine(34) transglycosylase acetylmuramyl- protein endolytic bifunctional [glutamate- deacylase: hydrolase tRNA ATP-binding an acetoacetyl-[acp] fatty acyl CoA synthase: homoserine D-alanyl-D-alanine protein AVM72_RS12575 semialdehyde RS08140 a malonyl-[acp] an oleoyl-[acp] acyl-CoA arg I: thrA (2Z)-2-aminobut-AVM72_RS05000 gln oxidoreductase MnmC: mnmC MltG: mltG L-alanine 2: mrdA transglycosylase -ammonia ligase]- AVM72_RS11515 NudE: nudE hydrolase: subunit RS14805 an acetoacetyl-[acp] AVM72_RS12465 dehydrogenase 3-phosphoserine/ carboxypeptidase/ 2: mrdA [+ 2 isozymes] dehydrogenase thioesterase: 2-enoate GTP diphosphokinase: relA a 5-aminomethyl-2- inosine 5'- 5'-deoxyadenosine Nucleoside and Nucleotide Degradation amidase MltG: mltG adenylyl-L-tyrosine pth ClpA: clpA 3-oxoacyl- 3-oxoacyl- SAM aspartate kinase: I: thrA phosphohydroxythreonine bifunctional (p)ppGpp lytic murein D-alanyl-D-alanine- D-alanyl-D-alanine D-alanyl-D-alanine PutA: putA AVM72_RS12575 biosynthetic thiouridine 34 in tRNA phosphate degradation II AmpD: ampD phosphorylase/ α RS05510 RS12795 ACP ACP beta-ketoacyl- AVM72_RS09560 transaminase: serC synthetase/guanosine- transglycosylase endopeptidase: dacB carboxypeptidase/ carboxypeptidase/ lytic murein an -D-aldose [+ 2 isozymes] reductase [+ 2 isozymes] arginine anthranilate PRPP aspartate kinase: 3',5'-bis(diphosphate) 3'- FAD-dependent 5- degradation B: mltB transglycosylase [glutamate-- D-tyrosine a tRNA Tyr glu reductase ACP synthase a 2,3,4-saturated adenosylmethionine spermidine biosynthesis I L-aspartyl-4-phosphate nucleoside- 5'-deoxyadenosine D-alanyl-D-alanine- D-alanyl-D-alanine- oleate 1-phosphate AMP a peptide decarboxylase: AVM72_RS09560 O-phospho- β γ ammonia-ligase] tRNA Asn RS14715 FabG: fabG a (3R)-3-FabG: fabG II: fabF fatty acid decarboxylase: speD L-aspartyl- diphosphate kinase: ndk pyrophosphohydrolase: carboxymethylaminomethyl- a peptidoglycan tetramer N-acetyl- -D- L-alanyl- -D- endopeptidase: dacB endopeptidase: dacB B: mltB asn RS14710 speA L-serine IMP adenylyltransferase: a (3R)-3- hydroxybutanoyl- aspartate- anthranilate 2-iminobutanoate 4-phosphate AVM72_RS08080 2-thiouridine(34) 5'-methylthioadenosine/ UTP and CTP dephosphorylation I a mature peptidoglycan a mature peptidoglycan with a D,D cross-link D-ala glucosamine-1,6- glutamyl-meso-2,6- SAM IMP glnE hydroxybutanoyl-[acp] [acp] dAdoMet agmatine semialdehyde phosphoribosyltransferase: trpD GDP oxidoreductase MnmC: mnmC adenosylhomocysteine with (L-alanyl-γ-D- strand (non- (Enterococcus faecium) anhydro-N-acetyl- diaminopimeloyl- a peptidoglycan a mature GlcNAc-1,6- RS09730 RS12800 an (11Z)-3-oxo- aspartate- dehydrogenase: β Nα,Nε-diacetyl- 3-hydroxyacyl- dehydrogenase: a 5-methylaminomethyl- nucleosidase: UTP glutamyl-meso-2,6- reducing terminus) -D-muramate D-alanine with D,D cross- D-ala peptidoglycan anhMurNAc- 3-hydroxyacyl- icos-11-enoyl-[acp] semialdehyde guaB D-ala (n) ACP adenosylmethionine AVM72_RS04630 2-thiouridine 34 in tRNA diaminopimeloyl-D- lysyl-D-alanine (meso-DAP L-Ala-γ-D-Glu- a [glutamine- RS07625 polyamine N-(5-phosphoribosyl)-anthranilate AVM72_RS08805 link (S. aureus) ACP dehydratase 3-oxoacyl-ACP decarboxylase: speD dehydrogenase: Aromatic Compound Biosynthesis XMP CTP synthase: alanine) tetrapeptide containing) DAP-D-Ala ADP synthetase]- RS07500 aminopropyltransferase: L-aspartate 4- ser dehydratase FabZ: fabZ reductase 2-oxobutanoate AVM72_RS04630 protein S-nitrosylation 5-deoxy-D-ribose AVM72_RS04420 L-tyrosine speE semialdehyde phosphoribosylanthranilate RS03205 FabZ: fabZ FabG: fabG putrescine dAdoMet L-aspartate 4- chorismate biosynthesis I and denitrosylation 5'/3'-nucleotidase a (2E)-but- sphingomyelin metabolism isomerase: AVM72_RS12445 serine 2,3-dihydroxybenzoate a 5-methylaminomethyl- SurE: surE S-methyl-5- UDP 4-hydroxy- semialdehyde a [protein]- CTP RS07230 a (2E)-but-2-enoyl-[acp] 2-enoyl-[acp] a (3R,11Z)-3-hydroxy- N 1 -(3-aminopropyl) 1-(2-carboxyphenylamino)-1- hydroxymethyltransferase: biosynthesis 2-(S-geranyl) thioribose kinase: di-trans,octa-cis UDP-N-acetyl- L-alanyl-γ-D-glutamyl-L- an N-formyl-L- an (S)-2- a peptidoglycan DNA with adenine:7,8- an N-terminal- tetrahydrodipicolinate D-erythrose pyrimidine 5'- a peptidoglycan 34 polyamine AVM72_RS08205 34 L-cysteine AVM72_RS10265 -undecaprenyl α dihydro-8- L-methionyl-L- a cytidine enoyl-ACP icos-11-enoyl-[acp] an N-acyl- agmatine synthase: deoxy-D-ribulose 5-phosphate (S)-2-aceto-2- bifunctional 4-phosphate thiouridine in tRNA nucleotidase: -D-muramoyl- lysyl-D-alanyl-D-alanine methionylaminoacyl- halocarboxylate dimer (generic) D-ala ATP ATP lys glu ala RS07165 enoyl-ACP aminopropyltransferase: 3-deoxy-7- phosphate γ oxoguanine mismatch threonyl-[protein] in tRNA Ile2 reductase 3-hydroxyacyl- sphingosylphosphorylcholine AVM72_RS03565 indole-3-glycerol- hydroxybutanoate aspartate kinase/ chorismate AVM72_RS03780 5-deoxy-α-D- L-alanyl- -D- tRNA D-alanine--D- biotin RNA RS03655 reductase speE gly phosphoheptulonate UMP FabI: fabI ACP dehydratase (2S,4S)-4- phosphate synthase: homoserine ribose 1-phosphate CDP glutamyl-meso-2,6- 1,6-anhydro-N- endolytic alanine ligase: FabI: fabI sphingomyelin synthase: aroF penicillin-binding HAD family FabZ: fabZ hydroxy-2,3,4,5- AVM72_RS12450 dehydrogenase a 5-methylaminomethyl- a [protein] 3- xanthosine 5'/3'-nucleotidase diaminopimeloyl- acetylmuramyl- peptide transglycosylase A/G-specific type I methionyl AVM72_RS12875 tRNA glutamate- RS07000 phosphodiesterase: S-methyl-5- protein 2: mrdA hydrolase: a butanoyl-[acp] spermidine spermidine tetrahydrodipicolinate I: thrA 3-deoxy-7- isochorismate 2-(Se-phospho) nitrosothio- SurE: surE D-alanyl-D-alanine L-alanine deformylase: MltG: mltG adenine aminopeptidase: biotin--[acetyl-CoA- polynucleotide lysidine(34) -cysteine a butanoyl-[acp] a (2E,11Z)-icosa- AVM72_RS03785 (1S,2R)-1-C-(indol-3- thioribose-1- D-alanyl-D-alanine AVM72_RS14330 D-alanine--D- 4-hydroxy- (R)-2,3-dihydroxy- phosphoheptulonate 34 L-alanine pyrimidine 5'- phospho-N- amidase def glycosylase: map carboxylase] ligase: adenylyltransferase synthetase ligase: gshA RS06960 2,11-dienoyl-[acp] sphingosylphosphorylcholine yl)glycerol 3-phosphate L-homoserine selenouridine in tRNA xanthosine phosphate carboxypeptidase/ HAD family lytic murein alanine ligase: RS04465 beta- tetrahydrodipicolinate 3-methylpentanoate 3-deoxy- synthase: aroF isochorismatase: CMP nucleotidase: acetylmuramoyl- AmpD: ampD mutY AVM72_RS14195 PcnB: pcnB TilS: tilS beta-ketoacyl- phosphorylase: isomerase: mtnA D-alanyl-D-alanine- peptide hydrolase: transglycosylase AVM72_RS02940 ketoacyl- enoyl-ACP a sphingosine reductase: tryptophan synthase: D-arabino- AVM72_RS12175 AVM72_RS03780 pentapeptide- ACP synthase L-homocysteine biosynthesis pgeF 5'/3'-nucleotidase endopeptidase: dacB deformylase: AVM72_RS15930 B: mltB an N-terminal L- D-alanyl-D-alanine γ-L-glutamyl- RS07865 ACP reductase ceramide AVM72_RS11430 AVM72_RS12435 heptulosonate 5-deoxy-D-ribulose transferase: II: fabF (2S,3S)-2,3- a 5-methylaminomethyl- SurE: surE uridine ditrans,octacis- a peptidoglycan def an apurinic site met threonyl-[protein] biotinyl-5'- a lysidine 34 D-alanine synthase FabI: fabI trpB 7-phosphate a [protein]- 1-phosphate AVM72_RS12900 RNA (S)-2,3,4,5- dihydroxy-2,3- 2-selenouridine 34 xanthine pyrimidine 5'- undecaprenyldiphospho- UMP undecaprenyldiphospho- within DNA adenylate in tRNA Ile2 RS06655 II: fabF (3S)-3-methyl-2- S-nitrosoglutathione pentapeptide γ GlcNAc-1,6- adenine a 3-oxohexanoyl-[acp] tetrahydrodipicolinate ser L-homoserine 3-dehydroquinate dihydrobenzoate L-cysteine nucleotidase: N-acetylmuramoyl-L- N-acetyl-(N- L-alanyl- -D-glutamyl- a (2R)-2- a lipid II RS13825 a gondoyl-[acp] indole oxopentanoate in tRNA D-ala a halide anion anhydro-MurNAc- a 3-oxohexanoyl- 2,3,4,5- synthase: aroB S-(hydroxymethyl) AVM72_RS03780 alanyl-γ-D-glutamyl-meso acetylglucosaminyl)muramate L-lysyl-D-alanine formate a L-methionylaminoacyl- hydroxy fatty acid branched-chain L-proline tRNA pentapeptide RS14335 3-oxoacyl- [acp] tetrahydropyridine- glutathione S-methyl-5'- -2,6-diaminopimeloyl- tryptophan synthase: amino acid biosynthesis I cytidine ACP 3-oxoacyl- 2,6-dicarboxylate N- 3-dehydroquinate dehydrogenase/ thioadenosine degradation I D-alanyl-D-alanine AVM72_RS12435 transaminase: (from L-glutamate) 2,3- urate acetaldehyde DHAP reductase ACP succinyltransferase: class III alcohol RS06235 RS05355 trpB AVM72_RS13905 O-acetyl-L- type II 3- dihydroxybenzoate S-methyl-5'- FabG: fabG reductase dapD glu dehydrogenase: homoserine hydrogen sulfide dehydroquinate thioadenosine a CDP- an (R)-2- an (R)-2- a [protein chain an N-terminal- a peptide with an adenosine 34 CDP-diacylglycerol AVM72_RS14230 34 sn-glycerol an N-modified a uracil in DNA RS05970 a (3R)-3- FabG: fabG N-succinyl-2-amino- ile glutamate 5- dehydratase: aroQ 5'-methylthioadenosine/ a 5,10-gly a uridine (R)-β-lysine elongation factor a glycyl-[tRNA Ala ] L-methionyl-L- an N-terminal Arg2 a protein a (3R)-3- biosynthesis I lipid IV biosynthesis (P. putida) Cell Structure Biosynthesis 3-phosphate diacylglycerol hypoxanthine halocarboxylate halocarboxylate aminoacyl-[tRNA] in [tRNA ] hydroxyhexanoyl-[acp] A lipid IV biosynthesis (E. coli) 6-ketopimelate trp kinase: proB S-(hydroxysulfenamide) adenosylhomocysteine methylenetetrahydrofolate in tRNA PRPP P]-L-lysine 34 alanyl-[protein] L-methionine Flp pilus hydroxyhexanoyl- A γ-L-glutamyl O-acetylhomoserine 3-dehydroshikimate ATP- 3-hydroxyacyl- a (3R)-3- N-succinyldiaminopimelate Storage Compound Biosynthesis glutathione Fatty Acid and nucleosidase: assembly RS05965 RS05720 [acp] DHAP a (3R)-3- 5-phosphate aminocarboxypropyltransferase/ HAD family HAD family uracil-DNA dependent ACP hydroxydecanoyl- UDP-N-acetyl- aminotransferase: Lipid Degradation AVM72_RS08805 CDP-diacylglycerol-- aminoacyl- D-tyrosyl-tRNA(Tyr) type I methionyl type I methionyl complex 3-hydroxyacyl- hydroxytetradecanoyl- UDP-N-acetyl- cysteine synthase: shikimate MTR tRNA uridine-5- hydrolase: hydrolase: elongation glycosylase: protease RS14155 dehydratase [acp] α-D-glucosamine AVM72_RS10775 glutamate-5- glycerol-3-phosphate 3- hypoxanthine-guanine tRNA deacylase: aminopeptidase: aminopeptidase: ATPase ACP [acp] α-D-glucosamine AVM72_RS01400 dehydrogenase: polyhydroxybutanoate biosynthesis β carboxymethylaminomethyl(34) AVM72_RS14330 AVM72_RS14330 factor P--(R) ung subunit FabZ: fabZ sn-glycerol N-succinyl-L,L-2,6- semialdehyde oleate -oxidation phosphatidyltransferase: phosphoribosyltransferase: hydrolase: AVM72_RS11515 map map component dehydratase Kdo transfer aroE S-methyl-5- synthesis GTPase MnmE: mnmE -beta-lysine HslV: hslV 3-phosphate acyl-ACP--UDP-N- diaminopimelate L-threonine dehydrogenase: hydroxylamine pgsA AVM72_RS04675 HAD family HAD family pth TadA: tadA FabZ: fabZ acyl-ACP--UDP-N- to lipid IV thioribose kinase: tRNA uridine-5- ligase: epmA a peptide RS06040 acetylglucosamine O- A AVM72_RS10215 shikimate acetyl-CoA hydrolase: hydrolase: an apyrimidinic uracil RS14150 a (2E)-hex-2-enoyl-[acp] acetylglucosamine O- succinyl- biosynthesis L-homocysteine oleate AVM72_RS10265 carboxymethylaminomethyl(34) [+ 2 isozymes] a (2E)-hex- glycerol-3- acyltransferase: lpxA IV (P. putida) AVM72_RS15930 AVM72_RS15930 site in DNA an N-terminal L- an inosine 34 acyltransferase: lpxA lipid IV diaminopimelate L-glutamate-5- synthesis enzyme MnmG: mnmG CMP 1-(3-sn- a tRNA Ala gly met met a peptide RS05390 2-enoyl-[acp] phosphate 1-O- A shikimate acetyl-CoA C- [a protein chain an uncharged alanyl-[protein] in [tRNA Arg2 ] enoyl-ACP CMP-Kdo (P. putida) desuccinylase: L-homoserine semialdehyde 5-MTR-1-P phosphatidyl) an N-modified reductase acyltransferase UDP-3-O-[(3R)-3- L-cysteine biosynthesis I alanine kinase acyltransferase: IMP elongation factor amino acid tRNA enoyl-ACP UDP-3-O-[(3R)-3- dapE -sn-glycerol an (S)-2- a (2R)-2- β PlsY: plsY racemization AroK: aroK AVM72_RS06270 34 a halide anion EF-P]-N-( -L- FabI: fabI reductase hydroxydecanoyl]- homoserine kinase: ammonium a 5-carboxymethylaminomethyluridine 3-phosphate a halide anion RS14390 a 1-acyl-sn α hydroxymyristoyl]-N- lipid IV(A) [+ 2 isozymes] a 7,8-dihydrofolate hydroxycarboxylate hydroxy fatty acid lysyl)-L-lysine 34 RS05370 N-acetyl- -D- α AVM72_RS02805 shikimate 3- oleoyl-CoA in tRNA FabI: fabI -glycerol 3- acetyl- -D-glucosamine 3-deoxy- L,L-diaminopimelate ser O-phospho- RS14120 a hexanoyl-[acp] glucosamine UDP-3-O-acyl-N- ala phosphate phosphate UDP-3-O-acyl-N- D-manno- L-homoserine (S)-1-pyrroline- L-alanine alanine acetoacetyl-CoA acyl-CoA a hexanoyl-[acp] 1-acyl-sn-glycerol- acetylglucosamine 3-phosphoshikimate 1- beta-ketoacyl- acetylglucosamine octulosonic diaminopimelate 5-carboxylate biosynthesis III racemase: alr dehydrogenase: an N 10 - an (S)-2- (R)-S- an N-terminal- a peptide with 3-phosphate deacetylase: threonine carboxyvinyltransferase: acetoacetyl- tRNA processing H O γ a D-aspartyl- 5-MTR-1-P FlgL acid epimerase: dapF AVM72_RS06265 phe diphosphate 2 SAH -L-glutamyl-(S)- gly asp L-methionyl-L- an N-terminal ser ACP synthase beta- deacetylase: pyrroline-5- alanine CoA formyltetrahydrofolate adenine halocarboxylate dGTP [tRNA ] lactoylglutathione acyltransferase: AVM72_RS12855 transferase: O-acetyl-L-serine synthase: thrC aroA PRPP 2-aminobutanoate seryl-[protein] L-alanine S-methyl-5- RS13970 II: fabF ketoacyl- AVM72_RS12855 UDP-3-O-(3- carboxylate cys racemase: alr 5-enolpyruvoyl- reductase: (2E,9Z)- threonine/serine RS13860 AVM72_RS12585 UDP-3-O-(3- waaA meso-diaminopimelate a polycistronic thioribose-1- ACP a 1,2-diacyl- hydroxymyristoyl) Kdo transfer to O-acetylhomoserine reductase: IscS subfamily D-ala shikimate 3- phbB octadecenoyl-CoA HAD family dehydratase: a 3-oxooctanoyl-[acp] hydroxydecanoyl) thr tRNA precursor phenylalanine 4- RdgB/HAM1 family non- D-tyrosyl-tRNA(Tyr) lactoylglutathione type I methionyl phosphate synthase sn-glycerol -α-D-glucosamine lipid IV I (E. coli) aminocarboxypropyltransferase/ AVM72_RS13400 cysteine desulfurase: phosphate (3R)-3- enoyl-CoA Inorganic Nutrient Metabolism hydrolase: 5'-methylthioadenosine/ glutathione aminopeptidase AVM72_RS05000 α α-Kdo-(2->6) A monooxygenase: canonical purine NTP lyase: gloA II: fabF 3-phosphate - -D-glucosamine UDP-3-O-(3- diaminopimelate AVM72_RS02310 hydroxybutanoyl- poly-[(R)-3- hydratase: adenine dGTPase: adenosylhomocysteine synthase: gshB deacylase: aminopeptidase: isomerase: FlgK 3-oxoacyl- -lipid IV cysteine synthase: chorismate AVM72_RS11880 pyrophosphatase: rdgB AVM72_RS14330 N: pepN L-serine UDP-3-O-(3- A CMP-Kdo lipid IV (E. coli) decarboxylase: lysA pro phosphoribosyltransferase: apt AVM72_RS04875 nucleosidase: AVM72_RS11515 map mtnA phosphatidate hydroxymyristoyl) A AVM72_RS01400 cysteine desulfurase: synthase: CoA hydroxybutanoate] AVM72_RS06275 glutathione ammonia-lyase: S-methyl-5- RS05030 ACP a 3-oxooctanoyl- hydroxymyristoyl) (P. putida) urea cycle phenylalanine 4- inorganic HAD family RS04865 cytidylyltransferase: glucosamine N- AVM72_RS04815 aroC polyphosphate AVM72_RS08805 synthase: gshB AVM72_RS00415 thio-D-ribulose reductase [acp] glucosamine N- lipid IV(A) (S)-3-hydroxy-(9Z) monooxygenase: diphosphatase: ppa hydrolase: glutathione methylglyoxal AVM72_RS00885 acyltransferase: 3-deoxy- lipid IV(A) 3- lys cys ala class I poly(R)- a tRNA precursor a tRNA precursor with -octadecenoyl-CoA metabolism AVM72_RS15930 an N-terminal pyruvate 1-phosphate FabG: fabG acyltransferase: phhA asp ala a peptide 3-oxoacyl- lpxD chorismate hydroxyalkanoic with a 5' extension a 5' extension and arg tRNA D-aspartate met L-seryl-[protein] FlgG a CDP- lpxD D-manno- deoxy-D-manno- triphosphate S-ribosyl-L- a (3R)-3- ACP diacylglycerol UDP-2-N,3-O-bis[(3R)- octulosonic acid acid synthase: and a long 3' trailer a short 3' extension long chain AMP 2'-deoxyguanosine ophthalmate UDP-2-N-[(3R)-3- octulosonic 10 + adenine homocysteine hydroxyoctanoyl-[acp] reductase 3-hydroxytetradecanoyl]- phaC ribonuclease polyphosphate 4a-hydroxy-N - phosphate H an (S)-2- RS15025 FlhB hydroxydodecanoyl]- acid transferase: waaA ammonium a halide anion FabG: fabG α-D-glucosamine P protein 3-oxo-(9Z)- formyltetrahydrofolate tyr hydroxycarboxylate 3-hydroxyacyl- 3-O-[(3R)-3- transferase: a (3R)-3- UDP-2,3- α-Kdo-(2->6)- poly-[(R)-3- RNase T component: octadecenoyl-CoA ACP hydroxydecanoyl]- waaA ribonuclease carbamoyl- RS06730 hydroxyoctanoyl- diacylglucosamine lipid IV (E. coli) hydroxybutanoate] exonuclease: rnpA acetyl-CoA C- polyphosphate dehydratase α α-Kdo-(2->4)-α- A [acp] -D-glucosamine PH: rph phosphate kinase 1: ppk1 an N-terminal- a [ribosomal diphosphatase: KDO transferase: rnt acyltransferase: a 5,10- a 2-thiouridine 34 an N-terminal a [DNA]-3'- a 5'-phospho- D-firefly RS04670 FabZ: fabZ 3-hydroxyacyl- CDP-diacylglycerol UDP-2,3- Kdo-(2->6)-lipid polyribonucleotide a tRNA precursor with synthase an L-phenylalanyl- NAD + a protein with glutathione a peptide with a H O a ribonucleoside FliR AVM72_RS05815 AVM72_RS06270 L-arginino- glu a (6S)-5- a PII protein 2 L-methionyl-L- protein L3]- biosynthesis II IV (P. putida) waaA a short 3' extension L-ornithine(glutamine- methylenetetrahydrofolate in tRNA arginyl-[protein] [tRNA Phe ] hydroxyl [DNA] luciferyl-CoA 5'-monophosphate IMP XTP ACP diacylglucosamine A nucleotidyltransferase: pnp formyltetrahydrofolate a disulfide bond leader sequence UTP valyl-[protein] L-glutamine a (2E)-oct-2-enoyl-[acp] α-Kdo-(2->4)-α-Kdo- succinate hydrolyzing) pyrimidine 5'- 50S ribosomal dehydratase diphosphatase: lipid X (7Z)-hexadecenoyl-CoA long chain 5'/3'-nucleotidase inosine/ RS06735 FabZ: fabZ DHAP AVM72_RS05815 (2->6)-lipid IV (E. coli) a tRNA precursor : carA carB tRNA uridine-5- NAD- acyl-CoA nucleotidase: protein L3 SurE: surE enoyl-ACP A polyphosphate leucyl/ xanthosine lipid-A- with a 5' extension acyl-CoA dependent bifunctional glutaredoxin signal [protein-PII] AVM72_RS03780 type I methionyl N(5)-glutamine RS04600 reductase a (2E)-oct- RNase T carbamoyl carboxymethylaminomethyl(34) phenylalanyl- thioesterase: pyrimidine 5'- triphosphatase: lipid X (P. putida) disaccharide ribonuclease dehydrogenase: DNA ligase tetrahydrofolate 3: grxC peptidase I: lepB uridylyltransferase: 5'/3'-nucleotidase aminopeptidase: methyltransferase: RS13640 FabI: fabI 2-enoyl-[acp] exonuclease: phosphate synthesis GTPase MnmE: mnmE tRNA--protein AVM72_RS04950 nucleotidase: yjjX sn-glycerol synthase: lpxB PH: rph AVM72_RS06265 ornithine LigA: ligA synthase/ glutaredoxin signal glnD SurE: surE map a [ribosomalprmB lipid-A- ribonuclease rnt tRNA uridine-5- transferase: [+ 2 isozymes] AVM72_RS03780 enoyl-ACP 3-phosphate lipid A disaccharide carbamoyltransferase: dihydrofolate 2: grxB peptidase I: lepB a ribonucleoside protein L3]- XDP RS14460 an octanoyl-[acp] disaccharide P protein (2E,7Z)- carboxymethylaminomethyl(34) aat inosine reductase (E. coli) pyrB synthase: folC N 5 -methyl- glycerol-3- synthase: lpxB component: hexadecenoyl-CoA L-citrulline synthesis enzyme MnmG: mnmG a uridylylated an N-terminal RS20640 FabI: fabI tetraacyldisaccharide [DNA] NMN met L-glutamine beta-ketoacyl- phosphate 1-O- lipid A rnpA enoyl-CoA a protein with PII protein D-firefly luciferin L-valyl-[protein] 4'-kinase: L-phenylalanyl-L- AMP GSSG RS13585 ACP synthase an octanoyl-[acp] acyltransferase disaccharide hydratase: a tRNA Phe a (6S)-5- reduced L- a leader sequence a peptide PlsY: plsY AVM72_RS05210 a 5-aminomethyl-2- arginyl-[protein] cysteine residues RS08495 II: fabF (P. putida) AVM72_RS06275 a 7,8-dihydrofolate 34 formyltetrahydrofolate a 1-acyl-sn thiouridine in tRNA tetraacyldisaccharide lipid IV (E. coli) (S)-3-hydroxy-(7Z) -glycerol 3- A RS04175 a 3-oxodecanoyl-[acp] 4'-kinase: -hexadecenoyl-CoA phosphate UDP-N-acetyl-α-D-muramoyl- (1S,2R)-1- sn-glycero-3- a 1-acyl-2- an N-terminal- S-methyl-5- an N-terminal- RS13460 1-acyl-sn-glycerol- AVM72_RS05210 an uncharged tRNA di-trans,octa-cis- an N-terminal an L-phenylalanyl- 3-aci- an acyl-CoA H O RNA 3-oxoacyl- γ phospho-N- arachidonoyl- L-methionyl-L- 2 thio-D-ribulose L-methionyl- lipid IV L-alanyl- -D-glutamyl-L- L-lysyl-[protein] Phe nitropropanoate ser C-(indol-3- dITP ITP RS15510 3-phosphate A undecaprenyl phosphate [tRNA ] ACP (P. putida) lysyl-D-alanyl-D-alanine yl)glycerol (arachidonoyl) sn-glycerol cysteinyl-[protein] 1-phosphatemethylthioribulose glycyl-[protein] acyltransferase: RdgB/HAM1 family inosine/ reductase 3-oxo-(7Z)- 3-phosphate ethanolamine 3-phosphate CTP 1-phosphate RS13320 FabG: fabG AVM72_RS12585 hexadecenoyl-CoA Carboxylate Degradation nitronate acyl-CoA non-canonical xanthosine a 1,2-diacyl- Cofactor, Carrier, and Vitamin Biosynthesis phospho-N- leucyl/ type I methionyl dehydratase: type I methionyl ribonuclease phenylalanyl- monooxygenase: tryptophan thioesterase: PH: rph purine NTP triphosphatase: RS04160 a (3R)-3- sn-glycerol queuosine biosynthesis I (de novo) acetyl-CoA C- acetylmuramoyl- glycerophosphodiester phosphatidate aminopeptidase: 5-(methylsulfanyl)AVM72_RS10280 aminopeptidase: tRNA--protein AVM72_RS14145 synthase: AVM72_RS04950 pyrophosphatase: yjjX RS09430 hydroxydecanoyl-[acp] 3-phosphate [2Fe-2S] iron-sulfur acyltransferase: pyruvate decarboxylation to acetyl CoA I pentapeptide- phosphodiesterase: cytidylyltransferase: map -2,3-dioxopentyl map superpathway of coenzyme A biosynthesis I (bacteria) acetate transferase: [+ 2 isozymes] AVM72_RS12435 [+ 2 isozymes] rdgB phosphatidate cluster biosynthesis ubiquinol-8 biosynthesis superpathway of heme b di-trans,poly-cis cytidylyl molybdenum superpathway of pyridoxal 5'-phosphate biosynthesis and salvage NAD de novo biosynthesis AVM72_RS06270 transferase: AVM72_RS04060 AVM72_RS00885 1-phosphate IDP RS13175 3-hydroxyacyl- preQ a [pyruvate conversion aat trpB a nucleoside dIMP cytidylyltransferase: (early decarboxylation) biosynthesis from glutamate -undecaprenyl cofactor sulfurylation I (from aspartate) 0 AVM72_RS12900 RNA ACP 3-methyl-2- a 5,10- D-erythrose NADPH-dependent 7- (5Z)-tetradecenoyl-CoA dehydrogenase to acetyl-CoA [unspecified an N-terminal L- an N-terminal diphosphate AVM72_RS00885 all-trans- phosphate biosynthesis cytidylyl molybdenum pyruvate a CDP-1-acyl- met met RS03965 dehydratase L-cysteine desulfurase oxobutanoate methylenetetrahydrofolate 4-phosphate cyano-7-deazaguanine E2 protein] N 6 3-oxopropanoate nitrite degradation D-glyceraldehyde sn-glycerol cysteinyl-[protein] a carboxylate glycyl-[protein] octaprenyl glu (2E,6E)-farnesyl cofactor (trioxo) acyl-CoA pyruvate acetate undecaprenyl-diphospho-N- L-phenylalanyl- anandamide 2-arachidonoyl- FabZ: fabZ a CDP- 4-hydroxybenzoate IPP asp reductase QueF: queF -lipoyl-L-lysine UMP Phe products] 3-phosphate trp 3-phosphate diphosphate glutamate- diphosphate dehydrogenase: dehydrogenase acetate- acetylmuramoyl-L-alanyl-γ-D- L-lysyl-[protein] a tRNA glycerol diacylglycerol IscS subfamily 3-methyl-2-oxobutanoate L-aspartate preQ dihydrolipoyl RS03620 -tRNA 1 -CoA a (2E)-dec-2-enoyl-[acp] cysteine hydroxymethyltransferase: an [MCD cofactor AVM72_RS06265 dehydrogenase: (acetyl- glutamyl-L-lysyl- D-alanyl-D-alanine 4-hydroxybenzoate ligase: gltX oxidase: nadB ligase: acs desulfurase: panB isoprenyl chaperone]-MCD 4-phospho- tRNA guanosine(34) (2E,5Z)- lpdA transferring), octaprenyltransferase: 2-iminosuccinate acetyl-CoA RS03770 enoyl-ACP AVM72_RS02310 glutamate-- transferase: D-erythronate transglycosylase Tgt: tgt tetradecenoyl-CoA homodimeric UDP-N-acetyl-α-D- a 2'- a peptide with γ a peptide with a [lipoyl-carrier an unstable ubiA asp IscS subfamily dihydrolipoyl 37 dihomo - an L-aspartyl- reductase AVM72_RS00880 type: aceE di-trans,octa-cis- a ferrocytochrome stearoyl-CoA an adenosine H O 6 carbonic acid tRNA ligase: quinolinate muramoyl-L-alanyl-γ-D- ala a pimeloyl-[acp] deoxyribonucleoside DMAPP an N-terminal 2 an N-terminal protein]-N -[(R) RecA filament- cysteine cysteine a 7-aminomethyl-7- dehydrogenase: [DNA] linolenoyl-CoA [tRNA Asn ] XTP 2-dehydropantoate ∆ 3 2 undecaprenyl phosphate b in tRNA RS13000 FabI: fabI fatty acid biosynthesis AVM72_RS05810 synthase -cis-∆ -trans- enoyl-CoA glutamyl-L-lysyl-D-alanine 5 5'-triphosphate Xaa-L-proline L-proline -dihydrolipoyl]- DNA complex desulfurase: 4-hydroxy-3- an L-glutamyl- aspartate 1- di-trans,octa-cis desulfurase: deazaguanosine 34 in tRNA AVM72_RS04655a [pyruvate a [pyruvate Asp-tRNA(Asn) RdgB/HAM1 family DNA a decanoyl-[acyl- initiation (type II) phosphatidylserine and Glu NadA: nadA enoyl-CoA hydratase: L-lysine dihydrolipoyl AVM72_RS04815 octaprenylbenzoate [tRNA ] decarboxylase: superpathway of tetrahydrofolate biosynthesis -undecaprenyl AVM72_RS02310 (3R)-3-hydroxy-2-oxo- tRNA preQ1(34) S- dehydrogenase dehydrogenase acyl-CoA /Glu-tRNA(Gln) carbonic non-canonical repair phosphatidylethanolamine isomerase: AVM72_RS06275 6 6 tRNA (adenosine(37)-N6) carrier protein] AVM72_RS04415 diphosphate 4 phosphooxybutanoate quinolinate E2 protein] N E2 protein] N -S- phospho-N- 8-amino-7- acyl-CoA DNA polymerase leucyl amidotransferase: dehydrogenase: anhydrase: protein RS03600 acetyl-CoA biosynthesis I an S-sulfanyl-[L- 4-hydroxy-3- glutamyl-tRNA cysteine adenosylmethionine AVM72_RS06275 dihydrolipoyllysine- -dimethylallyltransferase thioesterase: prolyl purine NTP beta-ketoacyl- undecaprenyl- 3-phosphoserine/ -dihydrolipoyl- acetyldihydrolipoyl- acetylmuramoyl- oxononanoate desaturase: III subunit chi: aminopeptidase: gatB gatA gatC AVM72_RS04655 AVM72_RS03065 RecO: acetyl-CoA cysteine desulfurase] polyprenylbenzoate reductase: β-alanine desulfurase: ribosyltransferase- (S)-3-hydroxy-(5Z) residue MiaA: miaA AVM72_RS04950 aminopeptidase: pip an L-asparaginyl- pyrophosphatase: RS12845 ACP synthase a CDP-diacylglycerol (R)-pantoate diphosphate phosphohydroxythreonine carboxylating L-lysine L-lysine pentapeptide- synthase: AVM72_RS09850 AVM72_RS03080 AVM72_RS03085 dihydrolipoyl a stabilizedrecO carboxylase decarboxylase: ubiD AVM72_RS08765 GTP AVM72_RS04815 isomerase QueA: queA (3E,5Z)-tetradeca- -tetradecenoyl-CoA acetyltransferase: [+ 2 isozymes] [tRNA Asn ] rdgB II: fabF CDP-diacylglycerol--serine phosphatase: a [cytidylyl molybdenum transaminase: serC nicotinate- transferase: AVM72_RS10660 [+ 7 isozymes] dehydrogenase: RecA filament- carboxyltransferase (S)-4-amino-5- 34 3,5-dienoyl-CoA aceF 6 XMP O-phosphatidyltransferase: 2-octaprenylphenol AVM72_RS06390 cofactor chaperone]- nucleotide an epoxyqueuosine in tRNA AVM72_RS12900 N -(3-methylbut- a peptide with a [lipoyl-carrierlpdA CO H O DNA complex subunit beta: pantoate--beta- 4-phosphooxy- 2 2 a 3-oxododecanoyl-[acp] pssA oxopentanoate GTP cyclohydrolase di-trans,octa-cis diphosphorylase: acyl-CoA a ferricytochrome oleoyl-CoA 2-en-1-yl)- a proteinogenic di-homo-γ- a peptide pro protein]-N 6 -[(R YidC AVM72_RS03955 a 3-sn-phosphatidyl- an S-sulfanyl-[cysteine alanine ligase: cytidylyl molybdenum L-threonine D-glyceraldehyde (8S)-8-amino-7- an N-terminal 2-octaprenylphenol glutamate-1- I FolE2: -undecaprenyl AVM72_RS11780 epoxyqueuosine thioesterase: b [DNA] adenosine 37 amino acid linolenate )-lipoyl]-L-lysine desulfurase]-[disordered- cofactor (sulfo-dioxo) pyruvate 3-oxo-(5Z)- undecaprenyl-diphospho-N UMP acyl-carrier protein 5 L-proline SecD malonyl-CoA L-serine 6-hydroxylase: AVM72_RS12185 AVM72_RS07325 4-hydroxythreonine- 3-phosphate reductase QueH: AVM72_RS04950 oxononanoate 3-oxoacyl- form scaffold semialdehyde phosphate tetradecenoyl-CoA -acetylmuramoyl-L-alanyl-γ- in tRNA phosphatidylserine AVM72_RS10820 7,8- 4-phosphate NaMN AVM72_RS13895 ACP ACP S- protein] complex 2,1- [+ 2 isozymes] acetyl-CoA D-glutamyl-L-lysyl- D-alanine decarboxylase: psd 3-(all-trans dihydroneopterin dehydrogenase acetyl-CoA C- reductase malonyltransferase: [cysteine desulfurase]-S- aminomutase: (R)-pantothenate 34 (3E,5Z)- -octaprenyl) 3'-triphosphate PdxA: pdxA nicotinate-nucleotide a queuosine in tRNA acyltransferase: RS12835 FabG: fabG fabD an L-1- sulfanylcysteine:[acceptor hemL tetradecadienoate adenylyltransferase: UDP-N-acetyl- undecaprenyldiphospho- a 2'- 46 RS12595 protein]-cysteine benzene-1,2-diol type III 3-amino-1- 1-deoxy-D- AVM72_RS06270 quinoxaline-2- an acyl-[acyl- a D-tryptophanyl- a guanine D-sedoheptulose (2R,3S)-2- a mismatched a (3R)-3- phosphatidylethanolamine glutamate-1- nadD α-D-glucosamine N-acetylmuramoyl-L- aryl-carrier protein deoxyribonucleoside ala pimeloyl-CoA aci-nitroethane a RNA-DNA hybrid bifunctional 2- pantothenate hydroxyacetone xylulose 5- lipoprotein posttranslational modification (3Z)-dodec- carboxyl adenylate [DNA] [tRNA Trp ] in tRNA 1-phosphate methylisocitrate ITP DNA base pair hydroxydodecanoyl-[acp] a malonyl-[acp] sulfurtransferase: semialdehyde γ carrier protein] 5'-triphosphate tRNA DNA polyprenyl-6- kinase: 7,8- pyridoxine 1-phosphate phosphate nicotinate adenine 3-enoyl-CoA C1 Compound Utilization and Assimilation alanyl- -D-glutamyl-meso AVM72_RS02310 2,1- (guanosine(46)-N7) RdgB/HAM1 family mismatch 3-hydroxyacyl- a [cysteine desulfurase]- hydroxyphenol AVM72_RS14200 dihydroneopterin dinucleotide a [prolipoprotein]- ∆3,∆2-enoyl- -2,6-diaminopimeloyl- ketoacyl-ACP aminomutase: pyridoxamine nitronate ribonuclease -methyltransferase fructose- methylisocitrate non-canonical repair YajC ACP S-sulfanyl-[disordered- methylase/3- 3'-phosphate pyridoxine 5'- L-cysteine CoA isomerase: formaldehyde oxidation D-alanyl-D-alanine phosphate DNA polymerase 8-amino-7- D-tyrosyl-tRNA(Tyr) SohB synthase III: hemL (R)-4'- pyridoxal NAD+ synthase: NAD+ synthase: acyl carrier monooxygenase: HII: rnhB TrmB: trmB bisphosphate lyase: prpB purine NTP protein dehydratase form scaffold demethylubiquinol 3- phosphate pyridoxal prolipoprotein AVM72_RS06275 VII (THF pathway) formaldehyde acyltransferase III subunit chi: oxononanoate deacylase: an N 7 - AVM72_RS09110 phosphopantothenate flavin biosynthesis I (bacteria and plants) kinase AVM72_RS09790 AVM72_RS09790 undecaprenyldiphospho- protein: acpP AVM72_RS14145 [+ 2 isozymes] aldolase class II: pyrophosphatase: MutS: mutS FabZ: fabZ protein] complex O-methyltransferase synthase: kinase diacylglyceryl oxidation II PlsX: plsX AVM72_RS03080 synthase: AVM72_RS11515 methylguanine 46 a properly IscS subfamily 5-aminolevulinate bifunctional chorismate PdxY: (2E)-dodec- muramoylpentapeptide beta-N- [+ 2 isozymes] AVM72_RS15610 rdgB an acetoacetyl-[acp] UbiG: ubiG pdxJ NAD + transferase: formaldehyde (glutathione-dependent) [+ 7 isozymes] AVM72_RS10660 in tRNA a (2E)-dodec- phosphopantothenoylcysteine pdxY PdxY: 2-enoyl-CoA acetylglucosaminyltransferase: matched cysteine 2-methoxy- D-erythro-7,8- AVM72_RS10295 a quinoxaline-2- a nucleoside 5'- pyruvate succinate IMP 2-enoyl-[acp] porphobilinogen decarboxylase/ aminodeoxychorismate/ pdxY formaldehyde murG DNA DNA base pair RS13210 desulfurase: 6-(all-trans- dihydroneopterin GTP a [prolipoprotein]- 3-hydroxyacyl-CoA carboxyl-[aryl- Trp RS12230 synthase: hemB anthranilate synthase AMP acyl-carrier protein an acyl phosphate D-tryptophan a tRNA acetaldehyde nitrite monophosphate DHAP D-erythrose enoyl-ACP AVM72_RS02310 octaprenyl)phenol phosphopantothenate-- pyridoxine pyridoxamine S-1,2-diacyl-sn- dehydrogenase/ a 5,10- carrier protein] [DNA] (8S)-8-amino-7- coenzyme A cysteine ligase CoaBC: coaBC dihydroneopterin component II: 5'-phosphate 5'-phosphate lipid II (meso UDP oxononanoate reductase cysteine 2-octaprenyl-6- porphobilinogen glyceryl-L-cysteine enoyl-CoA methylenetetrahydrofolate S-(hydroxymethyl) (R)-4'- aldolase: folB AVM72_RS09355 diaminopimelate containing) FabI: fabI desulfurase: methoxyphenol hydratase bifunctional glutathione phosphopantothenoyl- 6-(hydroxymethyl) [+ 2 isozymes] AVM72_RS04815 4-hydroxylase: hydroxymethylbilane pyridoxamine pyridoxamine lipoprotein family protein: methylenetetrahydrofolate RS12350 RS12140 a dodecanoyl-[acp] an S-sulfanyl-[cysteine L-cysteine -7,8-dihydropterin 4-amino-4- 2,5-diamino-6-(5-phospho-D- pyridoxal signal peptidase: AVM72_RS06275 S-(hydroxymethyl) di-trans,octa-cis β AVM72_RS10820 synthase: hemC 5'-phosphate 5'-phosphate dehydrogenase/ a [2-oxoglutarate- α N-acetyl- -D- a PepB guanine 37 D-sedoheptulose a protein-L- a [protein]-L- desulfurase]-S- 2-methoxy-6-all ribosylamino)pyrimidin-4(3H)-one glutathione a sulfurated UDP- -D-glucose 2-methylbutanoate 2-oxoglutarate a D-aminoacyl- chitin bifunctional 2-amino-4-hydroxy-6- deoxychorismate oxidase: pdxH oxidase: pdxH AVM72_RS15425 (S)-3- SAM dehydrogenase -undecaprenyl D-ala glucosaminyl-(1 aminopeptidase Phe 1,7-bisphosphate methionine- methenyltetrahydrofolate dehydrogenase/ [tRNA] in tRNA dGDP methionine sulfanyl-[disordered- trans-octaprenyl- preuroporphyrinogen phosphopantothenoylcysteine hydroxymethyldihydropteridine bifunctional [sulfur carrier] 6 phosphate -> 4)-N-acetyl- tRNA (R)-S-oxide peptide- aminodeoxychorismate pyridoxal 5'- pyridoxal 5'- pyridoxal hydroxydodecanoyl-CoA cyclohydrolase FolD: folD E2 protein] N - substrate peptide- beta-ketoacyl- fatty acid elongation -- saturated form scaffold 1,4-benzoquinol decarboxylase/ diphosphokinase: folK diaminohydroxyphosphoribosylaminopyrimidine an (S-diacyl-sn- a lipoprotein class III alcohol β-D-muramate (guanosine(37)-N1) ribonucleoside- methionine lyase: pabC phosphate phosphate kinase octanoyl-L-lysine acetate- beta-N- methionine (R)-S- ACP synthase protein] complex bifunctional uroporphyrinogen- phosphopantothenate-- (7,8-dihydropterin- deaminase/5-amino-6-(5-phosphoribosylamino) glyceryl)-L-cysteinyl- signal peptide a 5,10- dehydrogenase: -methyltransferase fructose- diphosphate (S)-S-oxide RS12260 RS09735 RS11930 [cysteine desulfurase]-S- synthase: synthase: PdxY: undecaprenyl- -CoA D-amino acid D-tyrosyl-tRNA(Tyr) acetylhexosaminidase: oxide reductase: II: fabF demethylmenaquinone III synthase: cysteine ligase CoaBC: coaBC 6-yl)methyl uracil reductase RibD: ribD [apolipoprotein] methenyltetrahydrofolate AVM72_RS14230 lipoyl aminopeptidase TrmD: trmD bisphosphate reductase: reductase an acetoacetyl-[acp] sulfanylcysteine:[acceptor 4-aminobenzoate AVM72_RS13865 AVM72_RS13865 pdxY signal peptide phosphate glucose aminotransferase: deacylase: beta-N- nagZ an N 1 - laurate methyltransferase/2- AVM72_RS13600 diphosphate apolipoprotein N- bifunctional synthase: ligase: acs PepB: pepB aldolase class II: AVM72_RS05635 AVM72_RS10780 protein]-cysteine 5-amino-6-(5-phospho- peptidase 3-oxododecanoyl-CoA S-formylglutathione phosphotransferase: AVM72_RS10945 AVM72_RS11515 acetylhexosaminidase: 37 MsrA: msrA methoxy-6-polyprenyl- 4'-phosphopantetheine methylenetetrahydrofolate methylguanine AVM72_RS15610 [+ 2 isozymes] AVM72_RS10785 a protein-L- a 3-oxotetradecanoyl- acyltransferase: lnt SppA: sppA lipA Phe sulfurtransferase: uroporphyrinogen-III dihydropteroate D-ribosylamino)uracil AVM72_RS13540 nagZ N-acetyl-D- in tRNA a [protein]-L- methionine- [acp] 1,4-benzoquinol PLP an N-acyl-(S-diacyl- acetyl-CoA C- dehydrogenase/ (2S)-2- chitin GDP RS07820 RS02100 a [cysteine AVM72_RS02310 pantetheine- synthase: folP bifunctional a [2-oxoglutarate glucosamine methionine (S)-S-oxide methylase UbiE: ubiE uroporphyrinogen sn-glyceryl)-L- a peptide acyltransferase: methenyltetrahydrofolate an unsulfurated methylbutanoyl- AMP diphosphate pyruvate an uncharged a proteinogenic D-erythrose RS12070 FlgH 3-oxoacyl- desulfurase]-(S- phosphate diaminohydroxyphosphoribosylaminopyrimidine bis(guanylyl molybdopterin) biotin biosynthesis 5'-deoxyadenosine met dehydrogenase α-D-glucopyranosyl- D-glt a D-amino acid N-acetyl-D- a peptide DHAP 6-methoxy-3- decarboxylase: cysteinyl-[lipoprotein] AVM72_RS06270 cyclohydrolase FolD: folD [sulfur carrier] UMP CoA tRNA GlcNAc amino acid 4-phosphate ACP lauroyl-CoA a 3-oxoacyl-[acp] sulfanyl) -[disordered- methyl-2-all- adenylyltransferase: 7,8- deaminase/5-amino-6-(5-phosphoribosylamino) cofactor sulfurylation from 8-amino-7- E2 protein] N 6 diphosphoundecaprenol muramate 2 AVM72_RS13415 D-ribulose 5-phosphate an N 10 - formate reductase form scaffold coaD dihydropteroate uracil reductase RibD: ribD oxononanoate I -lipoyl-L-lysine trans-octaprenyl- decanoyl-CoA formyltetrahydrofolate RS15665 FabG: fabG protein] complex 1,4-benzoquinol coproporphyrinogen III 3'-dephospho- bifunctional 3,4-dihydroxy- 5-amino-6-(5-phospho- cys (8S)-8-amino-7- a (3R)-3- CoA thiamine diphosphate salvage II oxononanoate acyl-CoA formyltetrahydrofolate RS12155 RS05985 3-oxoacyl- 2-octaprenyl-3- tetrahydrofolate 2-butanone- D-ribitylamino)uracil 6 37 all-trans- β 37 oxygen-dependent N -L-threonylcarbamoyladenosine dehydrogenase: a peptidoglycan dimer with (5Z,8Z,11Z,14Z,17Z) a [protein] N-terminal- -D-fructofuranose a guanine (3R,5S)-3- a supercoiled hydroxytetradecanoyl- ACP methyl-6-methoxy- dephospho- synthase/ 4-phosphate deformylase: purU 3-methylbutanoate hexaprenyl a DNA segment (S)-2- roseoflavin RS05650 beta- coproporphyrinogen IscS subfamily 4-amino-2-methyl-5- -modified tRNA biosynthesis AVM72_RS06265 pentapeptide stems (meso- DL-allothreonine -icosapentaenoyl-CoA 4-aminobenzoate formyl-L-methionine 1-phosphate in tRNA glu hydroxy-1- duplex DNA [acp] reductase 1,4-benzoquinol CoA kinase: dihydrofolate synthase: ribB (7R,8S)- diphosphate DDE-type integrase/ aminobutanoate bifunctional 3-hydroxyacyl- ketoacyl- a [cysteine desulfurase]- oxidase: hemF cysteine pyrimidinemethanol formate diaminopimelate containing) tRNA pyrroline-5- conjugative FabG: fabG hydroxylase: coaE synthase: folC diaminononanoate transposase/ riboflavin SecE ACP ACP [scaffold protein- 1-deoxy-L-glycero- desulfurase: thr (2E)-dec-2-enoyl-CoA (guanosine(37)-N1) carboxylatepyrroline-5- transfer AVM72_RS10820 ARP lipoate salvage II bifunctional acetate- acyl-CoA peptide fructose- recombinase: kinase/FAD dehydratase synthase a (3R)-3- (2Fe-2S)] complex protoporphyrinogen IX coenzyme A 7,8-dihydrofolate tetrulose 4-phosphate AVM72_RS02310 dethiobiotin 1,6-anhydro-N- serine 4-hydroxybenzoate -methyltransferase glutamate- carboxylate relaxase/ SecG a 2,3,4-saturated hydroxymethylpyrimidine threonylcarbamoyl- trans-∆ 2 -decenoyl- -CoA thioesterase: deformylase: def bisphosphate AVM72_RS16885 synthetase: II: fabF hydroxyacyl-[acyl- monoglutamate cysteine synthase: acetylmuramyl-L- hydroxymethyltransferase: octaprenyltransferase: 1 TrmD: trmD -cysteine reductase: helicase RS13690 FabZ: fabZ fatty acyl-[acp] 3-demethylubiquinol-8 a [lipoyl-carrier kinase/ AMP synthase: CoA hydratase: ligase: acs AVM72_RS04950 peptide aldolase class II: an N - ribF 3-hydroxyacyl- protoporphyrinogen bioD [+ 3 isozymes] 37 AVM72_RS13400 TraI: traI RS13550 carrier protein] 6,7-dimethyl-8- protein]-N 6 -[(R desulfurase: phosphomethylpyrimidine AVM72_RS00240 alanine amidase AVM72_RS08205 ubiA AVM72_RS15610 a DNA segment methylguanine ligase: gshA a (2E)-tetradec- ACP oxidase HemJ: hemJ AVM72_RS04815 (L-threonylcarbamoyl) AVM72_RS06275 AmpD: ampD [+ 2 isozymes] deformylase: def Hyp [+ 2 isozymes] roseoflavin RS01470 2-enoyl-[acp] a [co-chaperone]- bifunctional 2- ribityllumazine )-lipoyl]-L-lysine kinase: thiD dethiobiotin adenylate in reverse in tRNA a single 5'-phosphate dehydratase an [L-cysteine (S)-3- 3-methylbutanoyl- 3-all trans- lipid A MsbA lipid A [scaffold protein- polyprenyl-6- protoporphyrin IX synthase: ribE diphosphate orientation γ-L-glutamyl-(S)- stranded DNA enoyl-ACP FabZ: fabZ desulfurase]-S- HMP-P tRNA (adenosine(37)-N6)- hydroxydecanoyl-CoA γ AMP CoA acetaldehyde (5Z,8Z,11Z,14Z,17Z) hexaprenyl-4- an N-terminal L- D-glyceraldehyde (2Fe-2S)] complex hydroxyphenol a 7,8-dihydrofolate (R)-lipoate biotin a peptidoglycan dimer with L-alanyl- -D-glutamyl- gly coenzyme A formate DHAP 2-aminobutanoate reductase SSQ1 methylase/3- folate transformations III (E. coli) sulfanyl-L-cysteine synthase threonylcarbamoyltransferase pentapeptide stem (meso- meso-2,6-diaminopimeloyl- -icosapentaenoate aminobenzoate methionyl-[protein] ferrochelatase: dihydrofolate 6,7-dimethyl-8-(1-D-ribityl)lumazine IscS subfamily bifunctional 5-(2-hydroxyethyl) TET Tet TET RS02485 FabI: fabI chaperone: demethylubiquinol 3- lipoate-- BioB: bioB complex ATPase subunit diaminopimelate containing) D-alanyl-D-alanine PilW RS11145 hemH reductase: cysteine hydroxymethylpyrimidine -4-methylthiazole type 1 TsaE: tsaE a trans-2- dnaK O-methyltransferase a tetrahydrofolate riboflavin synthase: protein ligase: Alcohol Degradation a myristoyl-[acp] a 2,3,4-saturated enoyl-ACP a [chaperone-ATP]- AVM72_RS12055 desulfurase: kinase/ 9-mercaptodethiobiotin 3-oxodecanoyl-CoA UbiG: ubiG protoheme AVM72_RS00085 AVM72_RS04660 tRNA (adenosine(37)-N6)- 4 enoyl-[acyl- AVM72_RS02310 phosphomethylpyrimidine an N 10 - an O - a [protein]-S- a uridine 34 an sn-glycero-3- a [lipoyl-carrier an N-acyl-D- a cytidine succinate a sugar RS07235 a sugar fatty acyl-[acp] reductase [co-chaperone]- threonylcarbamoyltransferase hydrogen selenide an L-methionyl- a [protein]- palmitoleoyl-CoA H O (R)-lipoate an L-glutamyl- acetyl-CoA carrier protein] a tetrahydrofolate riboflavin synthase: [(R)- bis(guanylyl biotin acetyl-CoA C- glycerol and glycerophosphodiester degradation O-acetyl-L-serine methylthymine phospho-N-(acyl) 2 glucosamine 32 3',5'-ADP beta-ketoacyl- FabI: fabI [scaffold protein- ubiquinol-8 dihydrofolate cysteine kinase: thiD [initiator tRNA Met ] formyltetrahydrofolate L-cysteine sulfanyl-L-cysteine in tRNA protein]-L-lysine in tRNA [tRNA Gln ] semialdehyde 2+ 2+ glutathione lipoyl]adenylate molybdopterin) 4-methyl-5-(2- synthase complex dimerization ethanolamine 6-phosphate Zn RS14420 Zn ACP synthase (2Fe-2S)] complex reductase: AVM72_RS08190 desulfurase: acyltransferase: in DNA putative N- tRNA (cytosine(32) Asp-tRNA(Asn) NAD-dependent acetyl-CoA 3'(2'),5'- RS01200 biosynthesis lipoate-- cofactor HMP-PP phosphooxyethyl) BioB: bioB subunit type 1 TsaB: tsaB AVM72_RS06270 /uridine(32)-2'-O)- succinate- carboxylase a sugar RS08580 a sugar II: fabF AVM72_RS12055 AVM72_RS04815 an N 6 -L- glycerol acetylmannosamine- /Glu-tRNA(Gln) bisphosphate BamA enoyl-ACP riboflavin protein ligase: thiazole O-acetylhomoserine methylated-DNA-- tRNA 2- acyl-CoA lipoate-- methyltransferase semialdehyde biotin sulfite RS03815 sulfite a 3-oxohexadecanoyl- SSQ1 a [bis(guanylyl threonylcarbamoyladenine 37 methionyl-tRNA glycerophosphodiester 6-phosphate amidotransferase: nucleotidase reductase serine cys glu AVM72_RS04660 biotin octanoyl-CoA aminocarboxypropyltransferase/ [protein]-cysteine S- thiouridine(34) thioesterase: protein ligase: TrmJ: trmJ dehydrogenase: carboxylase [acp] chaperone bifunctional molybdopterin) thiamine in tRNA formyltransferase: phosphodiesterase: 2-epimerase: a 2'-O- gatB gatA gatC CysQ: cysQ Mg 2+ RS02785 Mg 2+ FabI: fabI a 7,8-dihydrofolatehydroxymethyltransferase:a 5-methyltetrahydrofolate a [glycine- cysteine synthase: methyltransferase: synthase AVM72_RS12575 AVM72_RS04660 an L-glutaminyl- AVM72_RS02715 subunit: accC ATPase: dnaK dipyrromethane glycine cleavage system riboflavin kinase/ cofactor [bis-MGD cofactor phosphate N-end rule pathway I (prokaryotic) acyl-CoA a glycerophosphodiester AVM72_RS12630 AVM72_RS04060 an N-acyl-α-D-AVM72_RS14555 methylcytidine 32 Na + RS03255 Na + 3-oxoacyl- AVM72_RS08205 a (6S)-5- AVM72_RS01400 MnmA: mnmA [+ 2 isozymes] [tRNA Gln ] AMP cofactor biosynthesis aminomethyltransferase FAD synthetase: ribF cleavage complex chaperone]-S- chaperone]- synthase: thiE dehydrogenase: AVM72_RS10640 mannosamine in tRNA succinate [+ 3 isozymes] ACP bifunctional formyltetrahydrofolate glutamate- 6 glycerol a [lipoyl-carrier a metal a metal RS10190 a [chaperone- GcvT: gcvT H protein] N -[(R sulfanyl-L-cysteine bis-MGD leucyl/ AVM72_RS06265 an N-formyl- 6-phosphate malonyl-CoA RS12150 an [2Fe-2S] an apo-[hydroxymethylbilane 34 an N- 6 RS10165 reductase ADP]-[disordered- methylenetetrahydrofolate 5-formyltetrahydrofolate -cysteine FMN )-lipoyl]-L-lysine phenylalanyl- glycerophosphodiester a tetrahydrofolate a [protein]-S- a [protein]- a 2-thiouridine sn-glycerol protein]-N -[(R cation cation chloride RS12820 chloride cluster protein synthase]-L-cysteine thymidylate dehydrogenase/ ligase: gshA phosphodiesterase: acetate L-selenocysteine L-methionyl- a thymine in DNA 3-phosphate acylethanolamine palmitoleate )-lipoyl]-L-lysine FabG: fabG form scaffold cyclo-ligase: thiamine phosphate tRNA--protein (2E)-oct-2-enoyl-CoA glycerol kinase met L-cysteine in tRNA biotin-carboxyl carrier synthase: bifunctional [initiator tRNA ] methyl-L-cysteine a (3R)-3- protein] complex methenyltetrahydrofolate AVM72_RS10850 transferase: GlpK: glpK AVM72_RS04060 a metal a metal 2+ 2+ protein assembly AVM72_RS10290 riboflavin kinase/ RS04610 Ca RS04905 Ca hydroxyhexadecanoyl- non- a [hydroxymethylbilane cyclohydrolase FolD: folD γ-L-glutamyl- thiamine- aat a [protein] 3-hydroxyacyl-CoA cation cation a 5,10- a 5,10- FAD synthetase: ribF a [lipoyl-carrier sulfo-bis(guanylyl an N-terminal [acp] synthase] ES intermediate L-cysteine 6 phosphate N-terminal L- dehydrogenase/ 6 a [biotin carboxyl- chaperonin 2 methylenetetrahydrofolate methenyltetrahydrofolate protein]-N -[(R molybdopterin) an O - RNase III mRNA 3 D-myo-inositol RS01820 3-hydroxyacyl- arginyl-[protein] leucyl-L-arginine enoyl-CoA sn-glycerol 3-phosphate O-acetyl-L- lysine within a [protein]- an N -methyladenine (+)-7-epi- lysine within a ribonucleoside 1,6-anhydro-N- L-histidinol 2+ 2+ carrier protein]-L-lysine molecular glutathione FAD )-lipoyl]-L-lysine cofactor kinase: thiL methanethiol an octanoyl-[acp] methylguanine processing H O (R)-lipoate (1,3,4,5)- RS01660 Cu RS09820 Cu ACP hydroxymethylbilane bifunctional gcv protein H L-cysteine in DNA jasmonoyl-CoA 2 gcv protein H diphosphate acetyl-β-muramate phosphate dADP a protein a metal a metal biotin--[acetyl-CoA- chaperone synthase: folate polyglutamylation hydratase homoserine in DNA substrate anhydro-N- tetrakisphosphate RS05155 dehydratase synthase: hemC methylenetetrahydrofolate thiamine diphosphate glycerol-3-phosphate ribonucleoside- histidinol- inosine/ cation cation carboxylase] ligase: ATPase: dnaK gshB leucyl/ family protein: acetylmuramic ribonucleoside- Peptide RS04585 Peptide FabZ: fabZ a [hydroxymethylbilane dehydrogenase/ AVM72_RS06275 dehydrogenase: glpD DNA-3- diphosphate phosphate xanthosine endopeptidase AVM72_RS14195 an [Fe-S cluster menaquinol-7 biosynthesis glutathione phenylalanyl- O-acetylhomoserine lipoyl(octanoyl) methylated-DNA-- acyl-CoA lipoate-- acid kinase: diphosphate synthase] ES intermediate methenyltetrahydrofolate a tetrahydrofolate ribonuclease methyladenine reductase: transaminase: triphosphatase: La: lon a metal a metal a (2E)-hexadec- a [biotin carboxyl- biosynthesis 3 thiamine diphosphate tRNA--protein (S)-3- transferase [protein]-cysteine S- thioesterase: protein ligase: RS06395 cyclohydrolase FolD: folD synthase: thiamine diphosphate DHAP aminocarboxypropyltransferase/ AVM72_RS10780 N-acetyl-D-AVM72_RS00275 3-(imidazol-4-AVM72_RS11900 D-myo-inositolyjjX reductase: cation cation RS04190 2-enoyl-[acp] carrier protein]-N chaperone]-ATP hydroxymethylbilane all-trans- biosynthesis glutathione- transferase: hydroxyoctanoyl-CoA LipB: lipB III: rnc glycosylase I: AVM72_RS04950 AVM72_RS04660 predicted 10 gshB 4-amino-2-methyl-5- biosynthesis I (E. coli) cysteine synthase: methyltransferase: AVM72_RS10785 AVM72_RS10780 6 1,4-dihydroxy- II (Bacillus) an N - glutaredoxin a [protein] AVM72_RS15345 a 2'- muramate 6- yl)-2-oxopropyl (1,3,4)- a peptide RS12255 ABC efflux enoyl-ACP -biotinyl-L-lysine synthase: hemC heptaprenyl diphosphomethylpyrimidine bifunctional serine an N-terminal aat AVM72_RS01400 AVM72_RS10640 [+ 2 isozymes] AVM72_RS10785 2-naphthoate formyltetrahydrofolate redox reactions N-terminal L- a [glycine-cleavage deoxyribonucleoside phosphate phosphate trisphosphate a metal a metal thiol transporter thiol reductase a [hydroxymethylbilane diphosphate HMP-PP glutathione biosynthesis I HMP-PP tetrahydrofolate hydroxymethyltransferase: L-lysyl-[protein] RNase III a [glycine-cleavage ADP RS07775 leucyl-L-lysine complex H protein] 6 5'-diphosphate cation cation of a thiol FabI: fabI synthase] ES intermediate thiamine glutathione thiamine synthase/ AVM72_RS08205 an N 10 - acyl-carrier protein a [protein]-S- an mRNA fragment processing an apurinic site (+)-7-epi- complex H protein] N 4 AIR acetate N 6 -octanoyl-L-lysine a guanine in DNA 3-methyladenine group a [biotin carboxyl- thioredoxin phosphate phosphate dihydrofolate formyltetrahydrofolate 3-oxooctanoyl-CoA met methyl-L-cysteine product mRNA within DNA jasmonate -[(R)-lipoyl]-L-lysine hydroxymethylbilane phosphomethylpyrimidine a palmitoyl-[acp] carrier-protein dimer]- pathway synthase: synthase: lipoate salvage I synthase: folC a 5,10- sulfate CysZ sulfate RS05575 RS01385 synthase: hemC tetrahydrofolate salvage from synthase ThiC: thiC bifunctional 6 thiE thiamine a reduced thiE methylenetetrahydrofolate acetyl-CoA C- RS14005 N -biotinyl-L-lysine demethylmenaquinol-7 5,10-methenyltetrahydrofolate tetrahydrofolate NADH repair (prokaryotes) an oxidized a holo-[hydroxymethylbilane thiamine diphosphate lipoate biosynthesis HMP-P glutaredoxin thiamine bifunctional acyltransferase: β acetyl-CoA acetyl-CoA (R)-lipoate a tetrahydrofolate synthase/ 2503 34 a thiocarboxylated N-acetyl- -D-glucosamine- 2251 32 1498 UDP-N-acetyl- synthase] phosphate and incorporation I phosphate Respiration AVM72_RS06270 adenine a single a uridine a 5-L-glutamyl- guanosine a uridine a uracil an unfolded carboxylase carboxylase thioredoxin bifunctional a 5,10- salvage I glutaredoxin lipoate-- tetrahydrofolate dihydrofolate [SAMP] C- 1,6-anhydro-N- an amino acid a type IV prepilin a sphingomyelin α-D-muramate a protein bifunctional NADH in 23S rRNA stranded DNA in tRNA [peptide] in 23S rRNA in tRNA in 16S rRNA protein RS11800 carboxyltransferase biotin demethylmenaquinone thiamine- methenyltetrahydrofolate thiamine 3: grxC thiamine- protein ligase: synthase/ synthase: folC hexanoyl-CoA terminal glycine acetyl-β-D-muramate 23S rRNA tRNA (cytosine(32) 16S rRNA UDP-N- RS01460 phosphate bifunctional hydroxymethylpyrimidine phosphate dihydrofolate 2-oxoglutarate decarboxylation to succinyl-CoA acetylmuramate ATP- palmitate subunit beta: carboxylase methyltransferase/2- an octanoyl-[acp] AVM72_RS04660 10 (guanosine(2251) /uridine(32)-2'-O)- (uracil(1498)-N(3))- methylenetetrahydrofolate kinase/ glutaredoxin [(R)- an N - exodeoxyribonuclease sphingomyelin dependent zinc chaperonin RS06475 AVM72_RS03955 subunit: accC thioredoxin- methoxy-6-polyprenyl- kinase: thiL lipoyl(octanoyl) kinase: thiL synthase: folC acyl-CoA 23S rRNA tRNA 2- -2'-O)- methyltransferase methyltransferase: dehydrogenase: RS06025 dehydrogenase/ phosphomethylpyrimidine 2: grxB lipoyl]adenylate formyltetrahydrofolate a [2-oxoglutarate VII: AVM72_RS02510 beta-N- phosphodiesterase: metalloprotease GroEL: groL a [carboxyl-carrier disulfide lipoate biosynthesis 1,4-benzoquinol thiamine transferase a protein with thiamine a 5,10- dehydrogenase: (adenine(2503)-C(2) thiouridine(34) prepilin peptidase: methyltransferase TrmJ: trmJ AVM72_RS12730 murB methenyltetrahydrofolate thiamine kinase: thiD lipoate-- dehydrogenase AVM72_RS02515 acetylhexosaminidase: AVM72_RS03785 a 2'-O- an N 3 - UDP-N-acetyl-α- FtsH: ftsH protein dimer]-N 6 - reductase: and incorporation II methylase UbiE: ubiE diphosphate LipB: lipB reduced L- diphosphate methylenetetrahydrofolate AVM72_RS06265 )-methyltransferase synthase AVM72_RS11390 RlmB: rlmB cyclohydrolase FolD: folD phosphate a [lipoyl-carrier protein] 6 nagZ 32 1498 RS11995 trxB 10 protein ligase: (R)-NADHX E2 protein] N 2-oxoglutarate RlmN: rlmN 2-O- methyluridine methyluracil D-glucosamine- a peptide a protein SecY carboxybiotinyl-L-lysine an N - 6 HMP-PP cysteine residues MnmA: mnmA thiamine- N -octanoyl-L-lysine AVM72_RS04660 -lipoyl-L-lysine (2E)-hexenoyl-CoA methylguanosine 2251 in tRNA in 16S rRNA enolpyruvate palmitoyl-CoA octanoate menaquinol-7 formyltetrahydrofolate bifunctional dehydrogenase a single-stranded α phosphate lipoyl a [lipoyl-carrier menaquinol-9 biosynthesis a ribonucleoside an -(5-L- a ceramide phosphocholine in 23S rRNA RS09390 lipoate-- ADP-dependent 2-oxoglutarate E1 component: 2503 1,6-anhydro-N- a cleaved type 6 a 2-methyladenine oligodeoxyribonucleotide 34 GlcNAc glutamyl)- phosphoribosylglycinamide kinase: thiL synthase: lipA protein]-N -[(R NAD(P)H-hydrate dehydrogenase 3-hydroxyacyl-CoA 5'-deoxyadenosine 5'-monophosphate a [SAMP] C- a 2-thiouridine β a peptide a peptide RS09160 a reduced protein ligase: menaquinol-6 biosynthesis AVM72_RS15000 in 23S rRNA met acetyl- -muramate amino acid IV prepilin menaquinol-8 biosynthesis formyltransferase: purN thiamine a [lipoyl-carrier )-lipoyl]-L-lysine dehydratase/ E1 component: dehydrogenase/ terminal glycine in tRNA thioredoxin a [lipoyl-carrier AVM72_RS04660protein] NADP demethylmenaquinol-9 RS12290 RS11385 S-adenosyl- diphosphate protein]-N 6 -[(R)- NAD(P)H-hydrate AVM72_RS15000 enoyl-CoA N 6 -octanoyl-L-lysine a tetrahydrofolate acyl carrier biosynthesis bifunctional L-methionine demethylmenaquinol-8 dihydrolipoyl]-L-lysine demethylmenaquinol-6 epimerase: [+ 2 isozymes] hydratase protein activation demethylmenaquinone a [2-oxoglutarate a [2-oxoglutarate β lipoyl biosynthesis bifunctional AVM72_RS11915 family protein: a [protein]- a DNA methyl N-acetyl- - a [release factor]- a 5,6- a [protein]-L- a protein bifunctional + methyltransferase/2- dehydrogenase dehydrogenase a ferrocytochrome palmitoyl-CoA coenzyme A an apo [peptidyl- glycerophosphoserine a proteinogenic glutathione fumarate 20 synthase: lipA NAD (S)-NADHX AVM72_RS06275 L-cysteine phosphotriester neuraminate asp L-glutamine dihydrouracil β-isoaspartate his with incorrect IPP demethylmenaquinone an apo acyl- demethylmenaquinone methoxy-6-polyprenyl- E2 protein] N 6 E2 protein] N 6 -S- b carrier protein] amino acid a [lipoyl-carrier met NAD(+) kinase: (S)-3- 5 peptide chain in tRNA protein-L- disulfide bonds isopentenyl- RS12320 MrcB methyltransferase/2- carrier protein methyltransferase/2- 1,4-benzoquinol bifunctional -dihydrolipoyl- succinyldihydrolipoyl- tRNA L-histidine N(alpha) thiol:disulfide 6 methionine AVM72_RS11450 release factor isoaspartate O- protein]-N -[(R)- methoxy-6-polyprenyl- holo-ACP synthase: methoxy-6-polyprenyl- methylase UbiE: ubiE ADP-dependent L-lysine L-lysine hydroxyhexanoyl-CoA methylated-DNA-- glycerophosphodiester N-acetylneuraminate dihydrouridine(20/ interchange diphosphate adenosyltransferase: NADP + L-aspartate N(5)-glutamine methyltransferase: -methyltransferase: dihydrolipoyl]-L-lysine 1,4-benzoquinol AVM72_RS06895 1,4-benzoquinol acyl-CoA holo-ACP synthase: lyase: 20a) synthase protein Delta- AVM72_RS15585 a holo acyl- menaquinol-9 NAD(P)H-hydrate [protein]-cysteine S- phosphodiesterase: oxidase: methyltransferase: AVM72_RS01665 AVM72_RS00510 methylase UbiE: ubiE methylase UbiE: ubiE desaturase: AVM72_RS06895 AVM72_RS14570 DusA: dusA a protein L-β- a proteinDsbG: dsbG isomerase: idi SAM carrier protein dehydratase/ methyltransferase: AVM72_RS04060 nadB prmC menaquinol-6 AVM72_RS09850 a uracil 20 in tRNA isoaspartate hercynine DMAPP RS11860 menaquinol-8 NAD(P)H-hydrate 2-oxoglutarate AVM72_RS10640 a [release factor]-N 5 with correct 3-oxohexanoyl-CoA N-acetyl-β-D- α-methyl ester RS00295 epimerase: dehydrogenase α γ -methyl-L-glutamine disulfide bonds 3',5'-ADP a holo [peptidyl- sn-glycerol an -( -L- mannosamine pyruvate 2-iminosuccinate succinate AVM72_RS11915 E1 component: a ferricytochrome carrier protein] a [protein]-S- ser glutamyl)-L- L-cysteinylglycine acetyl-CoA C- palmitoleoyl-CoA [DNA] 3-phosphate AVM72_RS15000 b methyl-L-cysteine amino acid NADH acetyltransferase: 5 RS12000 Carbohydrate Biosynthesis dihydrolipoyllysine- AVM72_RS11610 TrkA Nucleoside and Nucleotide Biosynthesis residue [+ 2 isozymes] β gluconeogenesis I succinyltransferase: an apo-[LYS2 L- all-trans- an N-acetyl- - an N-terminal L- a negatively a [protein]- 5-(methylsulfanyl) β coenzyme A isobutanoate a proteinogenic leukotriene-C4 [DNA] a protein with glyoxal lipid A-core biosynthesis ADP-L-glycero- -D-manno UDP-N-acetyl-D- CMP-pseudaminate biosynthesis CMP-3-deoxy-D- superpathway of pyrimidine sucB butanoyl-CoA meso-diaminopimelate UDP-N-acetyl-α-D-muramoyl- 2-aminoadipyl- 4-hydroxybenzoate heptaprenyl D-hexosaminide alanyl-[S18 protein supercoiled DNA L-tyrosine -2,3-dioxopentyl superpathway of guanosine inosine-5'-phosphate biosynthesis I superpathway of pyrimidine deoxyribonucleoside salvage amino acid DNA polymerase a disulfide bond (E. coli K-12) -heptose biosynthesis glucosamine biosynthesis I manno-octulosonate ribonucleotides de novo biosynthesis superpathway of TCA cycle TCA cycle I (prokaryotic) L-alanyl-D-glutamate carrier-protein] diphosphate of 30S ribosome]ribosomal protein DNA polysaccharide 1-phosphate protein- isoprenoid TolQ (S)-malate α biosynthesis nucleotides de novo biosynthesis I adenosine nucleotides acyl-CoA III subunit chi: topoisomerase biosynthesis biosynthesis α-D-Kdo-(2->4)-α-D- D-sedoheptulose D-glucopyranose UDP-N-acetyl- -D-glucosamine beta-N- S18-alanine N- acireductone disulfide D-ribulose de novo biosynthesis I AIR 2'-deoxycytidine dehydrogenase: acetate--CoA AVM72_RS03080 IV subunit B: parE tyrosine autokinase: glyoxalase RS12740 Kdo-(2->6)-lipid A (E. coli) 7-phosphate 6-phosphate UDP-N- gln acetyl-CoA UDP-N-acetylmuramoyl- holo-ACP synthase: 4-hydroxybenzoate acetylhexosaminidase: acetyltransferase: synthase: mtnC reductase phosphoheptose glucose-6- 5-phosphate hydrogencarbonate 5-(carboxyamino)imidazole AVM72_RS06265 ligase: acs [+ 2 isozymes] [+ 3 isozymes] AVM72_RS13475 ElbB: elbB malate lipopolysaccharide acetylglucosamine D-arabinose IMP nucleoside L-alanyl-D-glutamate-- AVM72_RS06895 octaprenyltransferase: nagZ an N-terminal N-acetyl-rimI a 2'- a [protein]- 1,2-dihydroxy-5- a protein withDsbD: dsbD isomerase: phosphate IMP ribonucleotide synthase: dehydrogenase: heptosyltransferase 4,6-dehydratase 5-phosphate asp deaminase: crotonyl-CoA 2, 6-diaminopimelate ubiA L-alanyl-[S18 protein deoxyribonucleoside a relaxed DNA L-tyrosine (methylsulfanyl) reduced L- glycolate D-glycero-D-AVM72_RS15080 isomerase: pgi AVM72_RS13350 oxaloacetate RS02605 AVM72_RS01655 I: waaC (inverting): pseB isomerase: carbamoyl- IMP AVM72_RS05585 ligase: AVM72_RS12910 a holo-[LYS2 L- an N-acetyl-β- of 30S ribosome] 5'-monophosphate phosphate pent-1-en-3-one cysteine residues manno-heptose F6P UDP-2-acetamido-2,6-dideoxy- N5-CAIR dCMP citrate synthase: enoyl-CoA isobutanoyl-CoA an α-(γ-L- an alcohol β aldehydo-D-AVM72_RS09205 phosphate dehydrogenase: 3',5'-ADP 2-aminoadipyl- diphosphate 3-heptaprenyl-4- D-hexosamine RS03270 pyruvate heptosyl-Kdo -lipid A 7-phosphate -L-arabino-hex-4-ulose adenylosuccinate (d)CMP kinase: AVM72_RS14975 hydratase: AMP glutamyl)-L- leukotriene-D4 oxaloacetate 2 glutamine-- arabinose 5- synthase guaB 5-(carboxyamino)imidazole 2'-deoxyuridine UDP-N-acetyl-α-D-muramoyl-L-alanyl- carrier-protein] hydroxybenzoate bifunctional D-glycero- UDP-4-amino-4, 6- synthase: AVM72_RS08275 AVM72_RS06275 amino acid lipopolysaccharide fructose-6- phosphate (glutamine- ribonucleotide mutase: purE γ-D-glutamyl-meso-2,6-diaminopimelate beta-D-manno- dideoxy-N-acetyl- AVM72_RS04090 (S)-3- RS02725 phosphoenolpyruvate heptosyltransferase phosphate hydrolyzing) XMP thymidine kinase: dCDP malate dehydrogenase: heptose-7-phosphate beta-L-altrosamine (S)-malate citrate hydroxybutanoyl-CoA synthase: ppsA II: waaF transaminase : carA carB CAIR AVM72_RS11785 AVM72_RS01655 UDP-N-acetyl- decaprenyl-diphospho-N- all-trans- a 2,3,4-saturated a 3,5,7,9,11,13,15- α kinase/D-glycero- transaminase: pseC nucleoside- an apo-[aryl- a [DNA]-3'- a holo [BryU acyl- a double dTDP- -D-glucose RS03550 (isomerizing) UDP-4-amino-4,6-dideoxy- D-arabinofuranose glutamine- adenylo-succinate thymidine α-D-glucosamine acetylmuramoyl-pentapeptide coenzyme A decaprenyl 1,2-diacyl-sn- D-cysteine hepta-oxo- stranded DNA a malonyl-[acp] val citrate (heptosyl) -Kdo -lipid A beta-D-manno- diphosphate β carrier protein] 4-hydroxybenzoate hydroxyl carrier protein] dTDP- 2 2 : glmS β carbamoyl hydrolyzing GMP phosphoribosylaminoimidazolesuccinocarboxamide dUMP aconitate hydratase fatty acid -oxidation I (generic) diphosphate glycerol 3-phosphate CTP DNA phosphoenolpyruvate heptose 1-phosphate N-acetyl- -L-altrosamine 5-phosphate asp kinase: ndk 1-aminocyclopropane-1- hexadecanoyl-[PKS-acp] branched-chain glucose 4,6- aconitate RS03060 D-glucosamine phosphate synthase: guaA adenylosuccinate synthase: purC AcnA: acnA undecaprenyldiphospho- aldo/keto ACP S- topoisomerase malonyl-ACP O- adenylyltransferase 3-deoxy-8- thymidylate thymidine kinase: class II fumarate acetoacetyl-CoA exodeoxyribonuclease carboxylate deaminase/D- amino acid dehydratase: hydratase phosphopyruvate 6-phosphate lyase: purB dCTP a (3Z)-alk-3- muramoylpentapeptide beta-N- 4-hydroxybenzoate phosphatidate reductase: malonyltransferase: IV subunit B: parE methyltransferase HldE: hldE phosphooctulonate SAICAR synthase: AVM72_RS11785 hydratase: fumC holo-ACP synthase: III: xthA cysteine desulfhydrase: transaminase: rfbB AcnA: acnA hydratase: eno D-glycero-β-D- aspartate GMP pyrimidine deoxyribonucleotides fumarate cis-aconitate enoyl-CoA acetylglucosaminyltransferase: octaprenyltransferase: cytidylyltransferase: AVM72_RS01375 fabD [+ 3 isozymes] BioC: bioC RS03680 glucosyl-(heptosyl) phosphoglucosamine UDP-2,4-diacetamido-2,4,6- synthase: kdsA AVM72_RS10290 aconitate hydratase acetyl-CoA C- AVM72_RS06895 [+ 2 isozymes] AVM72_RS08515 9-hydroxy-3,5,7,11,13,15- a malonyl- a negatively AVM72_RS13905 dTDP-4-dehydro- D-threo-isocitrate de novo biosynthesis I ∆ 3 2 murG a malonyl-[acp] 3-methyl-2- -Kdo -lipid A manno-heptose mutase: glmM trideoxy-β-L-altropyranose carbamoyltransferase: AMP adenylosuccinate AcnA: acnA acyltransferase: -cis-∆ -trans- ubiA AVM72_RS00885 pyruvate hexaoxohexadecanoyl- [BryU acyl- 6-deoxy-α-D- 2-phospho-D-glycerate 2 2 succinate dehydrogenase supercoiled DNA methyl ester oxobutanoate RS12765 1,7-bisphosphate α-D-glucosamine UDP-2,4-diacetamido- KDO-8P pyrB guanylate lyase: purB UDP CTP AVM72_RS06270 enoyl-CoA [PKS-acp] carrier protein] glucopyranose D-glycero- iron-sulfur subunit: a holo-[aryl- a [DNA]-3'- a 2'- 1-phosphate 2,4, 6-trideoxy-beta- kinase: gmk ribonucleoside- [+ 2 isozymes] isomerase: decaprenyl-pyrophosphoryl- UDP 3',5'-ADP 3-decaprenyl-4- a CDP-2,3,4-saturated- 2,3-bisphosphoglycerate- beta-D-manno- adenylate AVM72_RS14995 carrier protein] hydroxyl deoxyribonucleoside L-altropyranose N-carbamoyl- AICAR diphosphate dTMP AVM72_RS06275 (N-acetylglucosamine)-N- hydroxybenzoate diacylglycerol independent glucosyl-(heptosyl) - heptose 1,7- bifunctional UDP-N- kinase: adk CDP acetyl-CoA 5'-monophosphate RS03915 2 hydrolase: pseG L-aspartate reductase: succinate D-threo-isocitrate acetylmuramyl-(pentapeptide) phosphoglycerate Kdo -lipid A-phosphate acetylglucosamine GDP bifunctional dTMP kinase: 2 bisphosphate 7- AVM72_RS10780 a (2E)-2- RS12870 mutase: diphosphorylase/ 2,4-diacetamido-2,4,6- α-Kdo ADP phosphoribosylaminoimidazolecarboxamide ribonucleoside- AVM72_RS09075 enoyl-CoA phosphatase: trideoxy-β-L-altropyranose dihydroorotase: AVM72_RS10785 ADP-forming succinate- enoyl-CoA AVM72_RS12750 glucosamine-1- formyltransferase/IMP cyclohydrolase: purH diphosphate NADP-dependent isocitrate hydratase: a [glycine-cleavage all-trans- a 23S rRNA a guanosine 18 a uridine 13 a [protein]- phosphoenol gmhB AVM72_RS02120 dUDP dTDP -CoA ligase: sucC sucD coenzyme A AsbD acyl- glycerophosphoglycerol (2E,6E)-farnesyl a holo [BryP acyl- β phosphate N- pseudaminic acid 3-deoxy-manno- ribonucleoside- reductase: dehydrogenase: icd acyl-CoA a sulfurated [sulfur carrier] SAM complex H protein] hexaprenyl protoheme 1911/1915/1917 leu Ins(1,4,5)P D-glycero- -D- nucleoside- AVM72_RS06275 a 2,3,4- 4-hydroxybenzoate diphosphate uridine in tRNA in tRNA L-histidine 3 pyruvate 3-phospho-D-glycerate glucosyl-(heptosyl) - synthase: pseI octulosonate ribonucleoside- diphosphate FAICAR AVM72_RS10780 nucleoside- 5-aminoimidazole ribonucleotide biosynthesis I N 6 -octanoyl-L-lysine carrier protein diphosphate 23S rRNA tRNA carrier protein] tRNA RS04055 3 manno-heptose acetyltransferase (S)-dihydroorotate nucleoside- coenzyme A dehydrogenase: saturated (3R)-3- branched-chain inosine/ Kdo -lipid A-phosphate cytidylyltransferase: diphosphate diphosphate reductase: AVM72_RS10785 succinyl-CoA 2-oxoglutarate ACP S- histidine kinase: pyruvate 2 1-phosphate GlmU: glmU diphosphate diphosphate AVM72_RS06265 a 2,3,4- hydroxyacyl-CoA pseudouridine(1911/ (guanosine(18)-2'-O) pseudouridine(13) xanthosine RS03580 phosphoglycerate pseudaminate kinase: ndk reductase: bifunctional glycerophosphodiester malonyltransferase: amino acid N-acetyl-α-D- kdsB quinone-dependent AVM72_RS10780 kinase: ndk kinase: ndk PRPP a 2,3,4-saturated saturated (3S)-3- 4-hydroxybenzoate protoheme IX 1915/1917) -methyltransferase synthase TruD: AVM72_RS06830 triphosphatase: kinase: pyk kinase: bifunctional D-glycero- pseudaminic acid AVM72_RS10780 phosphoribosylaminoimidazolecarboxamide dCDP lipoyl holo-ACP synthase: phosphodiesterase: fabD transaminase: glucosamine dihydroorotate AVM72_RS10785 fatty acyl CoA hydroxyacyl-CoA octaprenyltransferase: farnesyltransferase: synthase RluD: rluD TrmH: trmH AVM72_RS04440 a [protein]- yjjX AVM72_RS15600 beta-D-manno- CMP-Kdo formyltransferase/IMP cyclohydrolase: purH dUTP dTTP AVM72_RS06895 AVM72_RS04060 1911/ a 2'-O- a malonyl- 13 AVM72_RS13905 cytidylyltransferase: AVM72_RS10785 nucleoside- synthase: lipA cyoE a pseudouridine a pseudouridine 4-methyl-2- N-phospho- pyruvate glucosyl-(heptosyl) -Kdo heptose-7-phosphate 1-phosphate dehydrogenase: amidophosphoribosyltransferase: purF 2-oxoglutarate ubiA methylguanosine 18 [BryP acyl- Ins(1,4)P RS04250 3 2 pseF GTP dUTP diphosphate 1915/1917 in 23S rRNA in tRNA 2 13-DPG bifunctional UDP-N- AVM72_RS09780 dADP dehydrogenase Glycolysis in tRNA carrier protein] oxopentanoate L-histidine -lipid A-bisphosphate kinase/D-glycero- IMP diphosphatase: kinase: ndk RS03685 acetylglucosamine CMP-pseudaminate GDP-mannose biosynthesis PRPP 5-phospho-β- gly E1 component: a 2,3,4-saturated a [glycine-cleavage 3',5'-ADP a holo-[AsbD acyl- glycerol sn-glycerol beta-D-manno- orotate 6 an unsulfurated 3-hexaprenyl-4- type I dGDP dut dCTP D-ribosylamine glycolysis III (from glucose) fatty acid a 2,3,4-saturatedacetyl-CoA C-a 2,3,4-saturated 5'-deoxyadenosine met complex H protein] N carrier protein] 3-phosphate ferroheme o heptose 1-phosphate diphosphorylase/ nucleoside- AVM72_RS15000 [sulfur carrier] hydroxybenzoate glyceraldehyde- glucosamine-1- D-glucopyranose diphosphate dUMP fatty acyl CoA acyltransferase:3-oxoacyl-CoA -[(R)-lipoyl]-L-lysine adenylyltransferase orotate nucleoside- 3-phosphate galactosyl-glucosyl- HldE: hldE phosphate N- 6-phosphate kinase: ndk phosphoribosylamine- D-glucopyranose AVM72_RS06270 RS04445 (heptosyl) -Kdo - glucose-6- phosphoribosyltransferase: diphosphate thymidylate PurT triose-phosphate dehydrogenase: 3 2 acetyltransferase -glycine ligase: purD ADP-D-glycero-β- phosphate AVM72_RS08365 synthase: a [pyruvate dehydrogenase E2 all-trans- sn-glycero-3- a cytidine 1402 a guanine 527 a double-stranded a [protein]-L- (3R)-3- uridine isomerase: gap lipid A-bisphosphate kinase: ndk Pentose Phosphate Pathways glucokinase: [EntB aryl- sn-glycerol GlmU: glmU dATP superpathway of pyrimidine pyrimidine ribonucleosides salvage I 6 coenzyme A glutathione dihydrolipoamide hydroxypentanoyl- D-manno-heptose isomerase: pgi AVM72_RS10290 a sulfurated [sulfur carrier] SAM protein] N -octanoyl-L-lysine 4-hydroxybenzoate nonaprenyl phosphoethanolamine hypoglycin A in 16S rRNA in 16S rRNA oligonucleotide proline (ω = 180) 3-phosphate AVM72_RS11765 D-glyceraldehyde UDP-N-acetyl- nucleobases salvage GAR AVM72_RS14905 carrier protein] diphosphate dihydrolipoyllysine- 16S rRNA 16S rRNA peptidylprolyl CoA uridine DHAP ADP- F6P orotidine 5'- dGTP dTMP glycerol-3- acetoacetyl- 3-phosphate α-D-glucosamine cytidine pentose phosphate pathway D-glucopyranose acetyl-CoA residue (cytidine(1402)-2'-O) (guanine(527)-N(7) oligoribonuclease: isomerase: kinase: udk glyceromanno- phosphate uracil glycerophosphodiester phosphate CoA RS13610 galactosyl-(glucosyl) mannose-1-phosphate dTMP kinase: phosphoribosylglycinamide (non-oxidative branch) I 6-phosphate acetyltransferase: -methyltransferase: )-methyltransferase orn AVM72_RS06765 RS13325 heptose 6- uracil holo-ACP synthase: 4-hydroxybenzoate phosphodiesterase: dehydrogenase: reductase: -(heptosyl) -Kdo - guanylyltransferase/ orotidine-5'- AVM72_RS09075 uridine nucleoside formyltransferase: purN D-ribulose aceF rsmI RsmG: rsmG [+ 3 isozymes] UMP 2 3 2 epimerase: rfaD UDP-α-D-glucose phosphoribosyltransferase: upp glucose-6- lipoyl synthase: lipA AVM72_RS06895 octaprenyltransferase: a 2'-O- an N 7 - a nucleoside 5'- glpD phbB lipid A-bisphosphate mannose-6- kinase: udk deaminase: AVM72_RS04060 a [protein]-L- β phosphate UMP 5-phosphate phosphate 1402 527 3-oxopentanoyl- fructose- ADP-L-glycero- - biosynthesis dTDP AVM72_RS05585 ubiA S-acetyldihydrolipoamide methylcytidine methylguanine monophosphate ω DHAP phosphate isomerase: decarboxylase: FGAR isomerase: pgi proline ( = 0) CoA bisphosphate UDP-α-D- D-manno-heptose D-glucopyranose nucleoside- CMP in 16S rRNA in 16S rRNA AVM72_RS13535 pyrF UMP kinase: pyrH ribulose- ribose-5- a holo-[EntB aryl- sn-glycerol FliN RS13410 aldolase class II: galactose 6-phosphate diphosphate uridine phosphoribosylformylglycinamidine F6P 5'-deoxyadenosine a [pyruvate dehydrogenase 3',5'-ADP 3-nonaprenyl-4- ethanolamine hypoglycin B L-cysteinylglycine galactosyl-(glucosyl) phosphomannomutase/ D-mannopyranose guanine and guanine and phosphate 3- phosphate met 6 an unsulfurated [sulfur carrier] carrier protein] 3-phosphate AVM72_RS15610 biosynthesis UMP UDP CMP kinase: ndk synthase: purL E2 protein] N -lipoyl-L-lysine hydroxybenzoate -(heptosyl) -Kdo - phosphoglucomutase: 6-phosphate guanosine salvage guanosine salvage II phosphorylation uridine epimerase: isomerase 3 3 2 6-phosphofructokinase: UDP-α-D-glucose AVM72_RS11965 UMP nucleoside- dTTP kinase: udk rpe RpiA: rpiA lipid A-bisphosphate α-D-glucopyranose phosphomannomutase/ FGAM AVM72_RS00170 UDP-glucose PRPP biosynthesis phosphoglucomutase: kinase: diphosphate kinase: ndk CMP Amino Acid Degradation β 1-phosphate UMP α undecaprenyl-diphospho-N 955/2504/ 1402 966 a 2,3,4- RS13515 -D-fructose 1,6- 4-epimerase pyrH guanosine guanosine (d)CMP kinase: D-xylulose D-ribose 5- β-D-fructose 1,6- UDP-N-acetyl- -D-glucosamine [EntF L-seryl- an isoprenoid hydrogen a reduced a ribonucleoside uridine a cytidine a guanine dCDP cytidine RS13695 AVM72_RS11965 UTP phosphoribosylformylglycinamidine -acetylmuramoyl-L-alanyl-γ- coenzyme A 4-hydroxybenzoate a single an acyl phosphate chorismate saturated (3R)-3- bisphosphate GalE: galE D-ribose 5- UTP--glucose- α AVM72_RS08275 5-phosphate phosphate bisphosphate L-arginine degradation diphosphate peroxide triphosphate 2580 in 23S rRNA in 16S rRNA in 16S rRNA ribonucleoside- core oligosaccharide-lipid -D-mannose UDP cyclo-ligase: purM carrier protein] thioredoxin stranded DNA 23S rRNA 16S rRNA 16S rRNA chorismate mutase: hydroxyacyl-CoA uridine UDP-α-D-galactose phosphate 1-phosphate CTP synthase: CDP II (AST pathway) L-tyrosine degradation I L-proline degradation I D-glutamyl-L-lysyl- D-alanine diphosphate acetoacetyl- A (E. coli K-12 core type) ribose-phosphate 1-phosphate pseudouridine(955/ (cytosine(1402)-N(4) (guanine(966)-N(2) acylphosphatase: AVM72_RS05035 kinase: udk pyrophosphokinase: uridylyltransferase nucleoside- AVM72_RS04420 nucleoside- AIR transketolase: tkt fructose- undecaprenyldiphospho- reductase: CoA GalU: galU mannose-1-phosphate diphosphate guanine guanine muramoylpentapeptide beta-N- holo-ACP synthase: 4-hydroxybenzoate peroxiredoxin C: 2504/2580) )-methyltransferase )-methyltransferase AVM72_RS12840 chorismate AVM72_RS08785 CTP diphosphate bisphosphate arg DNA primase: AVM72_RS10780 reductase: CMP RS04645 guanylyltransferase/ tyr pro octaprenyltransferase: synthase RluC: rluC 4 RsmH: rsmH 2 RsmD: rsmD mutase: pheA RS13785 F6P UTP--glucose- kinase: ndk kinase: ndk aldolase class II: acetylglucosaminyltransferase: AVM72_RS06895 AVM72_RS01815 AVM72_RS02030 955/ an N - an N - AVM72_RS10785 phbB PRPP gln D-sedoheptulose D-glyceraldehyde arginine N- tyrosine ubiA a pseudouridine a carboxylate a 2,3,4-saturated mannose-6- hypoxanthine-guanine hypoxanthine-guanine bifunctional murG methylcytidine 1402 methylguanine 966 prephenate core oligosaccharide- 1-phosphate UTP CTP 7-phosphate 3-phosphate AVM72_RS15610 succinyltransferase: aminotransferase: 2504/2580 in 23S rRNA CDP glucose-6- UDP phosphate isomerase: phosphoribosyltransferase: phosphoribosyltransferase: proline in 16S rRNA in 16S rRNA 3-oxoacyl-CoA uridylyltransferase 3-(4- a holo-[EntF phosphate lipid A (E. coli K-12 core AVM72_RS13535 AVM72_RS04675 AVM72_RS04675 N 2 -succinyl-astA AVM72_RS15170 dehydrogenase/L- ditrans,octacis-undecaprenyldiphospho- UDP an oxidized H O ssDNA/pppN(pN) GalU: galU CTP synthase: transaldolase: 3',5'-ADP L-seryl-carrier a 4-hydroxy-3- 2 isomerase: pgi type with D-GlcNAc) triose-phosphate L-arginine hydroxyphenyl) N-acetyl-(N-acetylglucosaminyl)muramoyl- thioredoxin hybrid FliO α glutamate gamma- protein] polyprenylbenzoate n -1 UDP-α-D-glucose GDP- -D-mannose AVM72_RS04420 AVM72_RS00625 isomerase: pyruvate L-alanyl-γ-D-glutamyl-L-lysyl-D-alanine RS13920 D-glucopyranose GMP GMP N-succinylarginine semialdehyde 6-phosphate AVM72_RS11765D-glyceraldehyde 4-hydroxyphenylpyruvate dehydrogenase CTP D-erythrose DHAP dihydrolase: astB F6P 3-phosphate dioxygenase: hppD PutA: putA 4-phosphate 2 UDP-N-acetyl-α-D-glucosamine undecaprenyl-diphospho-N-acetylmuramoyl-L- a DNA containing S-(2-hydroxyacyl) 2552 N -succinyl- (S)-1-pyrroline- acetoacetyl-CoA acetyl-CoA H O coenzyme A a [protein] (L-serine/L- a holo [PedN acyl- uridine putrescine a (2E,4Z)-2,4- a uridine in tRNA alanyl-γ-D-glutamyl-L-lysyl- D-alanyl-D-alanine 2 an apurinic/ Ap4A RS13700 type I L-ornithine homogentisate 5-carboxylate VibB glutathione threonine) phosphate in 23S rRNA dienoyl-CoA apyrimidinic site carrier protein] 23S rRNA NADPH-dependent tRNA transketolase: tkt glyceraldehyde- undecaprenyldiphospho- protein spermidine N1- symmetrical RS05335 succinylornithine ACP S- (uridine(2552)-2'-O) 2,4-dienoyl- dihydrouridine 3-phosphate homogentisate muramoylpentapeptide beta-N- hydroxymethylglutaryl- hydroxyacylglutathione phosphatase CheZ: acetyltransferase: bis(5'-nucleosyl)- D-glyceraldehyde transaminase: malonyltransferase: -methyltransferase CoA reductase: synthase dehydrogenase: 1,2-dioxygenase: acetylglucosaminyltransferase: CoA synthase: holo-ACP synthase: hydrolase: AVM72_RS04770 speG tetraphosphatase: 3-phosphate AVM72_RS10775 endonuclease fabD RlmE: rlmE AVM72_RS04245 DusB: dusB gap 2 AVM72_RS04960 L-glutamate-5- AVM72_RS06895 a malonyl[PedN a 2'-O- AVM72_RS09415 RS13790 N -succinyl- murG AVM72_RS00925 III: nth AVM72_RS13430 a [protein] Ser/Thr N-acetylputrescine a (2E)-2- a 5,6-dihydrouridine 4-maleyl- semialdehyde 2552 ADP L-glutamate 5- acyl-carrier methyluridine enoyl-CoA in tRNA RS14115 13-DPG semialdehyde acetoacetate protein] in 23S rRNA bifunctional ditrans,octacis-undecaprenyldiphospho-N- UDP a holo-[VibB aryl- a 2-hydroxy succinylglutamate- HMG-CoA 3',5'-ADP a 3'-terminal a 5'-phospho- glutathione phosphoglycerate maleylacetoacetate proline acetyl-(N-acetyl-β-D-glucosaminyl)muramoyl-L- carrier protein] carboxylate NADPH repair (prokaryotes) semialdehyde unsaturated sugar [DNA] RS05245 kinase: isomerase: maiA dehydrogenase/L- alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine dehydrogenase: AVM72_RS15600 4-fumaryl- glutamate gamma- NADPH astD semialdehyde Ffh acetoacetate (R)-S- UDP-4-amino-D-fucose UDP 3-phospho-D-glycerate 2 a sulfurated + RNase R degradation an insertion sequence a (2E,4E)-2,4- N - dehydrogenase dethiobiotin SAM H hydrogencarbonate [DNA] a holo [PedD acyl- spermine thr [sulfur carrier] substrate RNA lactoylglutathione UDP-4-amino-4, 6- element IS30 dienoyl-CoA ribonucleoside- succinylglutamate PutA: putA carrier protein] NADPH-dependent RS05345 2,3-bisphosphoglycerate- dideoxy-N-acetyl- transposase: spermidine N1- diphosphate succinylglutamate ACP S- 2,4-dienoyl- L-threonine 3- independent glu carbonic hydroxyacylglutathione beta-L-altrosamine AVM72_RS20935 acetyltransferase: reductase: desuccinylase: astE fumarate biotin exodeoxyribonuclease ribonuclease malonyltransferase: CoA reductase: dehydrogenase: RS14270 (R)-NADPHX phosphoglycerate anhydrase: hydrolase: transaminase: pseC fabD [+ 132 isozymes] speG tdh AVM72_RS10780 bifunctional mutase: synthase I: AVM72_RS14110 R: rnr an insertion AVM72_RS04245 L-histidine degradation I AVM72_RS03065 AVM72_RS13430 UDP-4-dehydro-6- a malonyl- 1 AVM72_RS10785 glu BioB: bioB sequence IS30 with N -acetylspermine a (2E)-2- aminoacetone RS14125 ADP-dependent AVM72_RS12750 deoxy-α-D-glucose [PedD acyl- enoyl-CoA dUDP NAD(P)H-hydrate a 2'- carrier protein] integrated transposon a nucleoside 5'- dehydratase/ 2-phospho-D-glycerate his biotin 5'-deoxyadenosine an unsulfurated CO H O deoxyribonucleoside [DNA] a diribonucleotide (R)-lactate glutathione L-serine degradation met 2 2 monophosphate RS06330 NAD(P)H-hydrate histidine [sulfur carrier] 5'-monophosphate epimerase: phosphopyruvate ammonia- RS14165 AVM72_RS11915 hydratase: eno ser lyase: hutH (S)-NADPHX urocanate ADP-L-glycero-β- α-Kdo-(2->4)- 1939 threonine/serine UDP-N-acetyl-α-D-muramoyl- a single- phosphoenol (9Z,12Z,15Z,18Z)-3- (R)-mevalonate a uracil (R)-3- a D-hexose phosphoenolpyruvate D-alanyl-D-alanine D-manno-heptose α-Kdo-(2->6)- hydrogencarbonate glycyl-glycine glutathione L-ornithine DNA with lesion dehydratase: L-asparagine L-alanyl-γ-D-glutamyl-L-lysine stranded RNA pyruvate oxotetracosatetraenoyl-CoA diphosphate in 23S rRNA hydroxybutanoate RS06845 bifunctional urocanate lipid IV (E. coli) 23S rRNA excinuclease A 3-hydroxybutyrate ADP-dependent pyruvate AVM72_RS05000 degradation I hydratase: acetoacetyl-CoA arginine N- glucokinase: RS06160 diphosphomevalonate (uracil(1939)-C(5)) dehydrogenase: ABC subunit NAD(P)H-hydrate kinase: pyk L-serine AVM72_RS02145 UDP-N-acetylmuramoyl- lipopolysaccharide reductase: phbB succinyltransferase: AVM72_RS14905 polyribonucleotide phosphoenolpyruvate decarboxylase: mvaD -methyltransferase AVM72_RS14550 UvrB: uvrB dehydratase/ ammonia-lyase: asn 4-imidazolone- tripeptide--D-alanyl- heptosyltransferase nucleotidyltransferase: pnp carboxylase: ppc RlmD: rlmD astA [+ 2 isozymes] pyruvate (3R,9Z,12Z,15Z,18Z)-3- 1939 N 2 -succinyl- D-hexose 6- NAD(P)H-hydrate 2-aminoprop-AVM72_RS00415 asparaginase: 5-propanoate D- alanine ligase: I: waaC IPP a 5-methyluracil acetoacetate DNA without RS14520 hydroxytetracosatetraenoyl-CoA L-ornithine phosphate epimerase: 2-enoate ansA AVM72_RS12905 in 23S rRNA lesion RS06510 AVM72_RS11915 imidazolonepropionase: hutI heptosyl- a nucleoside a single- γ-L-glutamyl- asp ADP Kdo -lipid IV oxaloacetate L-cysteinylglycine UDP-N-acetyl-α-D-muramoyl-L-alanyl- 2 A diphosphate stranded RNA glycylglycine NADPH N-formimino- γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine 2-iminopropanoate L-glutamate RS07310 6 RS00195 an (S-diacyl-sn- an N -L- α-D- 967 formimidoylglutamase: an L-1- 7,8-dihydrofolate + D-threo-7,8- a 5' triphospho- a cytosine propane- a supercoiled 37 NADPH H a [protein] Ser/Thr ethanol phosphatidylethanolamine glyceryl)-L-cysteinyl- threonylcarbamoyladenine monoglutamate dihydroneopterin glucopyranose [mRNA] in 16S rRNA 1,3-diamine thr duplex DNA hutG dTTP [apolipoprotein] in tRNA 1-phosphate RNA 16S rRNA serine/threonine spermidine N1- DNA tRNA threonine/serine catalase: pyrophosphohydrolase: (cytosine(967)-C(5) protein kinase: acetyltransferase: helicase pyruvate glycine cleavage glu threonylcarbamoyladenosine dihydrofolate dehydratase: AVM72_RS03860 RS07685 apolipoprotein N- dihydroneopterin glucose-1-phosphate rppH )-methyltransferase AVM72_RS00305 speG Rep: rep RS14545 dehydratase: AVM72_RS14385 reductase: AVM72_RS05000 6 aldolase: folB thymidylyltransferase RsmB: rsmB [+ 2 isozymes] a [glycine- acyltransferase: lnt a cyclic N -L- a 5'-phospho- 967 a [protein] (L-serine/L- N-(3-aminopropyl) L-threonine AVM72_RS12055 a 5-methylcytosine acetaldehyde a single cleavage complex threonylcarbamoyladenosine RfbA: rfbA [mRNA] threonine) phosphate acetamide 2-oxobutanoate degradation II in 16S rRNA stranded DNA H protein] N 6 -[(R glycine cleavage system an N-acyl-(S-diacyl- 37 in tRNA a 2-acyl-1-lyso- 5,6,7,8- 6-(hydroxymethyl) glycolaldehyde )-lipoyl]-L-lysine aminomethyltransferase sn-glyceryl)-L- NADP + α RS14765 RS07440 phosphatidylethanolamine tetrahydrofolate -7,8-dihydropterin dTDP- -D-glucose glycine cleavage system GcvT: gcvT thr cysteinyl-[lipoprotein] L-threonine 3- aminomethyltransferase [+ 2 isozymes] dehydrogenase: GcvT: gcvT DNA combined with 1518 tdh 3-methyl-2- 5,10-methylene- 6-[1-hydroxyethyl]-7- + adenine / (3R,7Z,10Z,13Z,16Z)-3- 3-heptaprenyl-4- L-2-amino-3- phylloquinone NAD(P)H H uroporphyrinogen-I a folate Ins(1)P MeOH wound RNA NhaA [+ 2 isozymes] a [glycine- oxobutanoate tetrahydromethanopterin methyl-7,8-dihydropterin exogenous DNA to form adenine 1519 in 16S rRNA hydroxydocosatetraenoyl-CoA hydroxybenzoate RS08265 a [glycine-cleavage oxobutanoate a recombinational junction 16S rRNA ATP- cleavage complex 2-amino-4-hydroxy-6- Holliday junction 4-hydroxy-3- uroporphyrinogen dihydrofolate inositol complex H protein] N 6 - (adenine(1518)-N(6)/ acetoacetyl-CoA catalase: dependent H protein] N 6 - glycine C- 3-methyl-2-oxobutanoate hydroxymethyldihydropteridine resolvase RuvX: ruvX polyprenylbenzoate decarboxylase: reductase: monophosphatase: aminomethyldihydrolipoyl- NAD(P)H:quinone adenine(1519)-N(6))- reductase: phbB AVM72_RS03860 RNA helicase dihydrolipoyl- acetyltransferase: hydroxymethyltransferase: diphosphokinase: folK crossover junction decarboxylase: ubiD AVM72_RS13415 AVM72_RS12055 AVM72_RS02300 L-lysine [1-(2-amino-7-methyl-4-oxo- oxidoreductase: dimethyltransferase HrpA: hrpA L-lysine AVM72_RS10600 panB endodeoxyribonuclease (7Z,10Z,13Z,16Z)-3- RS14790 7,8-dihydro-3H-pteridin- wrbA RsmA: rsmA 2-heptaprenylphenol coproporphyrinogen I a 7,8-dihydrofolate myo-inositol formaldehyde RS08490 RuvC: ruvC N 6 -dimethyladenine 1518 oxodocosatetraenoyl-CoA an unwound RNA gly 6-yl)]ethyl diphosphate resolution of recombinational junction formation /N 6 -dimethyladenine 1519 glycine cleavage system 2-dehydropantoate THMPT NAD(P) + phylloquinol of two intact strands in 16S rRNA aminomethyltransferase L-phenylalanine RS14870 L-glutamine GcvT: gcvT degradation degradation I I (aerobic) RS11545 N,N',N''- 5-amino-4- 38-40 + 1-aminocyclopropane- 3-decaprenyl-4- PRPP a uridine in tRNA NAD(P)H a plastoquinone H triacetylchitotriose uroporphyrinogen-III oxaloacetate spermidine Ins(2)P nitric oxide CAIR gln phe L-glutamate imidazolecarboxyamide 1-carboxylate hydroxybenzoate phenylalanine 4- RluA family pseudouridine uroporphyrinogen-III 4-hydroxy-3- spermidine N1- NO-inducible 5-(carboxyamino) Asp-tRNA(Asn) L-alanine degradation I 1-aminocyclopropane- inositol RarD monooxygenase: synthase: AVM72_RS02975 beta-N- C-methyltransferase: polyprenylbenzoate citrate synthase: acetyltransferase: flavohemoprotein: imidazole /Glu-tRNA(Gln) degradation IV NAD(P)H:quinone 1-carboxylate monophosphatase: AVM72_RS11880 adenine tRNA pseudouridine(38- acetylhexosaminidase: AVM72_RS13605 decarboxylase: ubiD AVM72_RS14975 speG hmpA ribonucleotide PhoR amidotransferase: glu oxidoreductase: deaminase/D-cysteine AVM72_RS02300 phenylalanine 4- phosphoribosyltransferase: apt 40) synthase TruA: truA nagZ 1,2-dihydroxypropane- N 1 - mutase: purE gatB gatA gatC NAD-glutamate wrbA desulfhydrase: precorrin-2 2-decaprenylphenol nitrate ala monooxygenase: a pseudouridine 38-40 in tRNA 1,2,3-tricarboxylate acetylspermidine myo-inositol AIR [+ 5 isozymes] dehydrogenase: AVM72_RS08515 alanine phhA RS14970 glu AVM72_RS07875 N,N'- N-acetyl-D- 2-oxobutanoate dehydrogenase: ald tyr 2-oxoglutarate AICAR a plastoquinol NAD(P) + diacetylchitobiose glucosamine pyruvate RS09460

2,5-diamino-6-(5- 4a-hydroxy-L- UDP-4-amino-4-deoxy- RNase G RS09200 a pseudouridine 1915 (9Z,12Z,15Z,18Z,21Z)-3- 3-nonaprenyl-4- a uridine 55 an aliphatic dCTP a cytidine 34 in tRNA β spermidine phospho-D-ribitylamino) erythro-5,6,7,8- in 23S rRNA oxotetracosapentaenoyl-CoA -L-arabinopyranose hydroxybenzoate in tRNA α,ω-diamine degradation pyrimidin-4(3H)-one tetrahydrobiopterin 23S rRNA UDP-4-amino-4, 6- dCTP deaminase: substrate mRNA RS09585 bifunctional tRNA (uridine(34)/cytosine(34)/5- 4a-hydroxytetrahydrobiopterin dideoxy-N-acetyl- 4-hydroxy-3- tRNA spermidine N1- spermidine N1- Detoxification (pseudouridine(1915)- acetoacetyl-CoA AVM72_RS06380 ribonuclease diaminohydroxyphosphoribosylaminopyrimidine carboxymethylaminomethyluridine(34) dehydratase: beta-L-altrosamine polyprenylbenzoate pseudouridine(55) acetyltransferase: acetyltransferase: N(3))-methyltransferase reductase: phbB G: rng RS09525 deaminase/5-amino-6-(5-phosphoribosylamino) -2'-O)- methyltransferase TrmL: trmL AVM72_RS10795 transaminase: pseC decarboxylase: ubiD synthase TruB: truB speG speG dUTP 34 RlmH: rlmH 55 8 arsenate arsenate reactive oxygen species degradation uracil reductase RibD: ribD a 2'-O-methylcytidine an N 3 - (3R,9Z,12Z,15Z,18Z,21Z)-3- UDP-β-L-threo- a pseudouridine N - an aliphatic N- arginine 5-amino-6-(5-phospho- (6R)-L-erythro-6,7- 2-nonaprenylphenol detoxification detoxification in tRNA methylpseudouridine 1915 hydroxytetracosapentaenoyl-CoA pentapyranos-4-ulose in tRNA acetylspermidine acetyl-diamine an mRNA fragment dependent dihydrobiopterin RS20850 III (thioredoxin) II (glutaredoxin) D-ribitylamino)uracil in 23S rRNA superoxide acid resistance RS09595 arsenate arsenate α arsenate arsenate arg a 5-carboxymethylaminomethyluridine 34 4a-hydroxy-N 10 - UDP-N-acetyl- 3-phenyl-2- UDP-2-acetamido-4-amino- N,N'- a 4-hydroxy-3- α-D-ribose- UDP- -D- an organic CTP α α Fe 2+ reductase reductase biosynthetic in tRNA Leu formyltetrahydrofolate -D-glucosamine oxopropanoate 2,4,6-trideoxy- -D-galactose diacetylchitobiose polyprenylbenzoate 1-phosphate glucuronate hydroperoxide UDP-4-amino-4, 6- RS09805 (glutaredoxin) (glutaredoxin) hydrogen arginine tRNA (uridine(34)/cytosine(34)/5- 4a-hydroxytetrahydrobiopterin UDP-N-acetylglucosamine beta-N- 4-hydroxy-3- bifunctional UDP-4- dCTP deaminase: 4-hydroxyphenylpyruvate dideoxy-N-acetyl- phosphopentomutase: peroxiredoxin C: : arsC : arsC peroxide decarboxylase: carboxymethylaminomethyluridine(34) dehydratase: 1-carboxyvinyltransferase: acetylhexosaminidase: polyprenylbenzoate keto-pentose/UDP- AVM72_RS06380 bacterioferritin: bfr RS00435 dioxygenase: hppD beta-L-altrosamine AVM72_RS03725 AVM72_RS01815 arsenite arsenite speA -2'-O)- methyltransferase TrmL: trmL AVM72_RS10795 murA nagZ decarboxylase: ubiD xylose synthase: agmatine UDP-N-acetyl-α-D- transaminase: pseC N-acetyl-D- AVM72_RS09580 UTP catalase: a 5-carboxymethylaminomethyl- an N 10 -formyl- (2-hydroxyphenyl) UDP-2-acetamido-2,6- a 2-(all-trans- D-ribose 5- glucosamine-enolpyruvate glucosamine UDP-α-D-xylose an alcohol Fe 3+ ala RS05185 ala AVM72_RS03860 2'-O-methyluridine 34 in tRNA Leu 7,8-dihydrofolate acetate dideoxy-α-D-xylo-hex-4-ulose polyprenyl)phenol phosphate

RS00130 H O hydroxyl radical a reduced arsenite arsenite O 2 2 H O c-type 2 cytochrome RS13190 an oxidized O c-type a dicarboxylate 2 cytochrome an inorganic an pro sn-glycerol an amino an amino a lipopolysaccharide a lipopolysaccharide queuosine Fe 2+ anion oligopeptide 3-phosphate acid acid a polysaccharide a lipopolysaccharide

predicted ABC predicted ABC RS09800 RS00175 RS09255 RS08465 RS07965 PomA RS06810 RS05980 RS05535 RS05325 RS13890 RS13760 RS04710 RS13505 RS04045 RS03660 RS03265 RS02950 RS02525 RS02290 RS01795 RS01475 UbiB RS01220 RS15505 RS10685 RS10525 MreD RS10450 RS10430 RS00620 RS10180 RS13470 efflux transporter of efflux transporter of LptA RS08860 RS00985 OppF RS10175 RS10210 RS00700 PutP GlpT RS10520 RS15445 RS01045 RS01185 RS11005 RS01455 RS11375 RS02110 RS02435 RS12410 SecF RS10470 RS13195 RS04220 RS04605 FlhA RS10360 RS14190 RS05715 LolD RS07005 RS07680 RS14880 RS08750 RS09375 RS00020 FeoB a lipopolysaccharide a lipopolysaccharide

an inorganic an sn-glycerol an amino 2+ queuosine pro Fe a polysaccharide a lipopolysaccharide anion oligopeptide 3-phosphate acid an amino a lipopolysaccharide a lipopolysaccharide acid a dicarboxylate This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.