Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000091785Cyc: Legionella longbeachae NSW150 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari sn-glycerol spermidine 3-phosphate putrescine a sulfonate nitrate hydrogencarbonate predicted predicted ABC ABC transporter transporter RS16610 of sn- of spermidine/ glycerol 3- putrescine phosphate a sulfonate nitrate spermidine hydrogencarbonate putrescine sn-glycerol 3-phosphate

Amino Acid Degradation Amine and Polyamine Biosynthesis Hormone Biosynthesis Aldehyde Degradation glutaminyl-tRNA gln Aminoacyl-tRNA Charging N 6 -(3-methylbut- a 1-palmitoyl-2- L-alanyl-γ-D- L-alanyl-γ-D- a [bis(guanylyl a [protein] biosynthesis via transamidation core a peptide with homospermidine homospermidine indole-3-acetate L-leucine degradation I a sulfurated 2-en-1-yl)- acyl-sn-glycerol glutamyl-meso-2,6- glutamyl-meso- UDP-N-acetyl- a [glutamine- γ-L-glutamyl- Polyprenyl Biosynthesis L-proline degradation I L-tyrosine degradation I methylglyoxal degradation I oligosaccharide- ATP molybdopterin) cys a type IV prepilin gly an N-terminal C-terminal glu biosynthesis II L-arginine degradation [sulfur carrier] 37 synthetase]- ATP biosynthesis I biosynthesis TCA cycle TCA cycle I (prokaryotic) adenosine lipid A (E. coli 3-phosphate diaminopimeloyl- UDP-N-acetyl- diaminopimelate α-D-muramate cofactor D-alanine L-alanine L-glutamate biotin II (AST pathway) L-tyrosine glu IV (bacteria) L-histidine degradation I in tRNA K-12 core type) D-alanine α-D-muramate chaperone]- putrescine putrescine (indole-3-yl) octaprenyl di-trans,poly-cis leu methylglyoxal diphosphate -undecaprenyl acetyl-CoA pro tyr (no GlcNAc) UDP-N- L-cysteine prepilin glutathione aminopeptidase homospermidine homospermidine acetonitrile arg lactoylglutathione tRNA (N6-isopentenyl 30S tyr tyr nitrile hydratase bifunctional acetylmuramate:L- bifunctional [glutamate- peptidase: synthetase: N: pepN biotin-- synthase: synthase: biosynthesis phosphate biosynthesis arginine N- his lyase: UDP-N- ribosomal RS12835 gln subunit beta: 4-methyl-2- proline adenosine(37)-C2)- lipid IV(A) alanyl-gamma-D- -ammonia ligase]- [acetyl-CoA- LLO_RS16880 LLO_RS16880 (2E,6E)-farnesyl (2E,6E)-farnesyl oxaloacetate 3-(4- LLO_RS17315 acetylmuramate:L- IscS subfamily LLO_RS08110 LLO_RS17480 aminopeptidase protein sym- sym- LLO_RS09720 IPP IPP succinyltransferase: histidine (R)-S- methylthiotransferase adenylyl-L-tyrosine carboxylase] trp trp an L-glutamyl- diphosphate diphosphate 2-methylcitrate oxopentanoate dehydrogenase/L- hydroxyphenyl) palmitoyltransferase alanyl-gamma-D- glutamyl- meso- cysteine prepilin glutathione N: pepN S6--L- tyr tyr (indol-3-yl) 2 LLO_RS08720 ammonia- lactoylglutathione MiaB: miaB imidazole Gln homospermidine homospermidine N -succinyl- glutamate gamma- PagP: pagP diaminopimelate phosphorylase/ ligase: [tRNA ] acetamide synthase: prpC pyruvate lyase: hutH glutamyl- meso- desulfurase: peptidase: synthase: glutamate RS12840 L-arginine semialdehyde [+ 2 isozymes] ligase: mpl [glutamate-- LLO_RS10545 glycerol isoprenyl malate dehydrogenase:citrate (Si)-synthase: gltA urocanate hydroxyacylglutathione diaminopimelate LLO_RS11720 LLO_RS08195 gshB ligase: rimK Asp-tRNA(Asn) amidase: octaprenyl 4-hydroxyphenylpyruvate ammonia-ligase] trp trp phosphate LLO_RS12985 N-succinylarginine dehydrogenase hydrolase: gloB 6 a 2-acyl-sn a hepta- ligase: mpl /Glu-tRNA(Gln) LLO_RS08515 diphosphate transferase: 3-methylbutanoyl- dioxygenase: hppD N -(3-methylbut- cysteine ala a peptide V-type ATP synthase: PutA: putA urocanate 5'-deoxyadenosine an unsulfurated adenylyltransferase: + + synthase: LLO_RS13650 malate dehydrogenase: dihydrolase: astB (S)-1-pyrroline- 2-en-1-yl)-2- met -glycerol 3- acylated core UDP-N-acetyl- desulfurase: a [protein] C- biotinyl-5'- H H hisF hisH amidotransferase: amidase: CoA hydratase: (R)-lactate [sulfur carrier] glnE a cleaved type synthase LLO_RS13530 LLO_RS14435 2 5-carboxylate homogentisate (methylsulfanyl) phosphate oligosaccharide UDP-N-acetylmuramoyl- α-D-muramoyl- LLO_RS15510 a peptide norophthalmate terminal α-L- adenylate gatC gatA gatB LLO_RS08535 isovaleryl-CoA N -succinyl- LLO_RS07520 IV prepilin [+ 7 isozymes] di-trans,octa-cis (S)-malate citrate adenosine 37 lipid A (E. coli γ L-alanyl-γ-D- glutamate-α- a 5-phosphooxy- octaprenyl dehydrogenase: L-ornithine L-alanyl- -D- (indol-3-yl)acetate -undecaprenyl homogentisate 4-imidazolone- in tRNA K-12 type) glutamyl-meso-2,6- a [glutamine L-glutamate ammonium L-glutamyl- diphosphate LLO_RS05520 glutamyl-meso-2,6- a [bis(guanylyl 1,2-dioxygenase: + F0F1 ATP + Gln diphosphate 5-propanoate synthetase]-O H H [tRNA ] synthase: aconitate hydratase: diaminopimeloyl- diaminopimelate ala molybdopterin) 3-methylcrotonyl- LLO_RS05895 4 -(5'-adenylyl) synthase LLO_RS02325 L-glutamate-5- imidazolonepropionase: pyruvate D-alanine cofactor LLO_RS16895 CoA N 2 -succinyl- 4-maleyl- -L-tyrosine Asp-tRNA(Asn) [+ 4 isozymes] semialdehyde LLO_RS04200 chaperone]-S- class II fumarate methylcrotonoyl- L-glutamate 5- /Glu-tRNA(Gln) all-trans- di-trans,octa-cis acetoacetate sulfanyl-L-cysteine hydratase: fumC CoA carboxylase: semialdehyde bifunctional N-formimino- met RS05480 met amidotransferase: octaprenyl -undecaprenyl fumarate maleylacetoacetate cis-aconitate LLO_RS05505 succinylglutamate- proline gatC gatA gatB diphosphate phosphate aconitate hydratase: isomerase: maiA L-glutamate semialdehyde dehydrogenase/L- a mature peptidoglycan a carboxy- a [glutamine L-alanyl-γ-D- L-alanyl-γ-D- LLO_RS02325 3-methylglutaconyl- a [DNA]-3'- a 5'-phospho- + formimidoylglutamase: NAD + menadione NADH H an acyl-CoA H O a D-tyrosyl- succinate dehydrogenase dehydrogenase: glutamate gamma- 4-fumaryl- (meso-diaminopimelate adenylated- synthetase]-O glutamyl-meso-2,6- glutamyl-L-lysyl- 2 ser sec thr thr [+ 4 isozymes] CoA Secondary Metabolite hydroxyl [DNA] cys [tRNA Tyr ] ATP roseoflavin a tRNA an L-glutaminyl- LLO_RS04190 4 flavoprotein subunit: sdhA astD semialdehyde acetoacetate containing) [ThiS sulfur- -(5'-adenylyl) diaminopimeloyl- D-alanyl-D-alanine RS13265 [tRNA Gln ] methylglutaconyl- Degradation 5'-phosphate 2 dehydrogenase -L-tyrosine tRNA charging CoA hydratase: N - carrier protein] D-alanine serine serine glu DNA ligase: NADH-quinone tol-pal system- LLO_RS05500 succinylglutamate PutA: putA myo-inositol degradation I lytic murein penicillin- D-tyrosyl- serine- LLO_RS05160 oxidoreductase: associated a sugar RS14200 a sugar succinate D-threo-isocitrate transglycosylase LD- binding tRNA(Tyr) bifunctional -tRNA IscS subfamily LLO_RS01430 bifunctional [glutamate- acyl-CoA gln Gln NADP-dependent isocitrate HMG-CoA glu fumarate NAD- riboflavin a tRNA myo-inositol B: mltB cysteine -ammonia ligase]- carboxypeptidase: protein deacylase: ligase: Ala asp ser dependent LLO_RS01435 thioesterase: a tRNA ala tRNA asp ser a tRNA dehydrogenase: icd LLO_RS02355 2: mrdA LLO_RS05405 kinase/FAD serS elongator ADP-forming succinate- hydroxymethylglutaryl- [+ 4 isozymes] DNA ligase desulfurase: nuoE nuoF adenylyl-L-tyrosine ybgC phe a tRNA Phe gly a tRNA Gly met initiator tRNA Met met thr a tRNA Thr asn tRNA Asn pro a tRNA Pro val a tRNA Val lys a tRNA Lys cys a tRNA Cys glu a tRNA glu his a tRNA His trp a tRNA Trp ile a tRNA Ile leu a tRNA Leu arg a tRNA Arg tyr a tRNA Tyr inositol 2- synthetase: a sugar RS11370 a sugar Met -CoA ligase: sucC sucD glu LLO_RS11720 phosphorylase/ LD- [+ 2 isozymes] tRNA glutamine-- CoA lyase: L-citrulline degradation dehydrogenase: LigA: ligA LLO_RS01450 [+ 3 isozymes] ribF a mature peptidoglycan cysteine [glutamate-- carboxypeptidase: alanine- tRNA ligase/ aspartate- serine- LLO_RS05490 a mature peptidoglycan nuoH nuoI an L-seryl- iolG γ ammonia-ligase] γ a tRNA Tyr with (L-alanyl- -D- strand (non- desulfurase: LLO_RS01465 LLO_RS03860 L-alanyl- -D- D-tyrosine sec phenylalanine- glycine--tRNA methionine-- methionine-- threonine- asparagine- proline-- valine-- -tRNA lysine- YqeY domain cysteine-- glutamate- histidine- -tRNA tryptophan-- isoleucine- leucine-- arginine-- tyrosine-- -tRNA acetoacetate L-methionine degradation roseoflavin [tRNA ] L-citrulline glutamyl-meso-2,6- reducing terminus) [DNA] NMN LLO_RS15510 nuoK nuoN adenylyltransferase: glutamyl-L- D-ala a carboxylate sulfate RS13435 sulfate -tRNA ligase: ligase: glyQ tRNA ligase: tRNA ligase: -tRNA -tRNA tRNA ligase: tRNA ligase: ligase: -tRNA fusion protein: tRNA ligase: -tRNA -tRNA ligase: tRNA ligase: -tRNA tRNA ligase: tRNA ligase: tRNA ligase: ligase: succinyl-CoA 2-oxoglutarate I (to L-homocysteine) scyllo-inosose adenine ornithine diaminopimeloyl-D- AMP glnE L-alanyl-γ-D- lysyl-D-alanine pheS pheT LLO_RS05430 LLO_RS01010 LLO_RS01010 ligase: thrS ligase: asnS LLO_RS04140 LLO_RS04215 alaS ligase: lysS LLO_RS06005 LLO_RS06010 ligase: gltX ligase: hisS aspS LLO_RS09060 ligase: ileS LLO_RS11855 LLO_RS12750 LLO_RS13340 serS dinucleotide alanine) tetrapeptide L-serine degradation met carbamoyltransferase: myo-inosose-2 a thiocarboxylated- D-ala glutamyl-meso- an L-methionyl- argF dehydratase: iolE ala [ThiS sulfur- NAD + menadiol a [glutamine- diaminopimelate an L-phenylalanyl- an L-methionyl- an L-threonyl- an L-asparaginyl- an L-prolyl- an L-valyl- an L-alanyl- an L-lysyl- an L-glutaminyl- an L-cysteinyl- an L-glutamyl- an L-histidyl- an L-aspartyl- an L-tryptophanyl- an L-isoleucyl- an L-leucyl- an L-arginyl- an L-tyrosyl- an L-seryl- methionine AMP sulfate RS04070 sulfate a glycyl-[tRNA Gly ] [elongator 2-oxoglutarate carbamoyl phosphate 3D-(3,5/4)- carrier protein] synthetase]- [tRNA Phe ] [initiator tRNA Met ] [tRNA Thr ] [tRNA Asn ] [tRNA Pro ] [tRNA Val ] [tRNA Ala ] [tRNA Lys ] [tRNA Gln ] [tRNA Cys ] [tRNA Glu ] [tRNA His ] [tRNA asp ] [tRNA Trp ] [tRNA Ile ] [tRNA Leu ] [tRNA Arg ] [tRNA Tyr ] [tRNA ser ] adenosyltransferase: ADP tRNA Met ] dehydrogenase E1 ser trihydroxycyclohexane- L-tyrosine LLO_RS12690 glutamine-hydrolyzing component: LLO_RS02045 L-serine SAM 1,2-dione carbamoyl-phosphate ammonia-lyase: 3D-(3,5/4)- Peptide RS07515 Peptide synthase small 2-aminoprop-LLO_RS10520 trihydroxycyclohexane- a ring-opened 7- a single a peptide with a [ThiI sulfur- L-threonine subunit: carA an adenine in DNA a uracil in DNA oleoyl-CoA H O a D-aspartyl- a protein with 1,2-dione acylhydrolase methylguanine an N-terminal carrier protein]- cys 2 2-enoate stranded DNA asp dGDP Amino Acid Biosynthesis Nucleoside and Nucleotide Biosynthesis degradation II carbamoyl-phosphate ATP a tRNA precursor [tRNA ] a disulfide bond (decyclizing): iolD in DNA Xaa-L-proline L-cysteine Dam family site- protein- Ca 2+ RS00150 Ca 2+ synthase large CTP specific DNA- ribonucleotide- SAH disulfide L-histidine biosynthesis superpathway of purine nucleotides de novo biosynthesis I Fermentation thr subunit: carB 5-deoxy-D-glucuronate exodeoxyribonuclease (adenine-N6)- uracil-DNA tol-pal system- diphosphate L-lysine biosynthesis I L-tryptophan biosynthesis L-proline superpathway of pyrimidine superpathway of adenine and superpathway of pyrimidine bifunctional DNA- leucyl IscS subfamily D-tyrosyl- reductase L-threonine 3- VII large subunit: methyltransferase: glycosylase: associated reductase: alanine L-glutamineL-alanine ribonucleotides de novo biosynthesis adenosine nucleotides adenosine salvage III 2-iminopropanoate adenosylhomocysteinase: L-glutamine formamidopyrimidine multifunctional aminopeptidase: cysteine tRNA(Tyr) DsbD: dsbD biosynthesis I Metabolic Regulator nucleobases salvage pyruvate fermentation to acetoin III dehydrogenase: carbamate LLO_RS10365 LLO_RS08700 acyl-CoA LLO_RS07370 Ca 2+ RS16365 Ca 2+ PRPP racemization biosynthesisbiosynthesis IIII PRPP de novo biosynthesis I LLO_RS05565 degradation I glycosylase/ CCA addition/ LLO_RS13375 desulfurase: LLO_RS12965 deacylase: (from L-glutamate) Biosynthesis uracil tdh exodeoxyribonuclease uracil-DNA thioesterase: protein- LLO_RS07375 asp chorismate gln L-2-amino-3- repair protein: Dam family site- LLO_RS05405 gln adenosylhomocysteinase: 5-dehydro-2- DNA-(apurinic Xaa-Pro LLO_RS11720 ybgC disulfide ATP bifunctional glu hydrogencarbonate adenine uracil VII small subunit: glycosylase: GDP ala cysglu ppGpp metabolism amidophosphoribosyltransferase: purF IMP pyruvate LLO_RS12685 oxobutanoate gln deoxy-D-gluconate or apyrimidinic LLO_RS01605 aminopeptidase: cysteine specific DNA- reductase phosphoribosyltransferase: aspartate kinase/ asp purine-nucleoside phosphoribosyltransferase: upp LLO_RS02940 LLO_RS12445 [+ 3 isozymes] a metal a metal alanine glutaminecysteine glutamate 5- glycine C- imidazole site) lyase: mutM tRNA pepP desulfurase: (adenine-N6)- DsbD: dsbD RS16350 LLO_RS06715 anthranilate UMP 5-dehydro-2- a protein with cation cation diaminopimelate synthetase:desulfurase: β phosphorylase: pyruvate L-homocysteine CO glycerol methyltransferase: asp racemase: alr kinase: proB 5-phospho- - gly L-alanine 2 nucleotidyltransferase: LLO_RS15510 tRNA synthase component γ pppGpp glutamine- ubiquinone- acetyltransferase: deoxygluconokinase: D-aspartate reduced L- 1-(5-phospho- decarboxylase: LLO_RS05685LLO_RS15510 -L-glutamyl D-ribosylamine LLO_RS09110 phosphate a single-stranded LLO_RS14875 an apyrimidinic uracil hypothetical I: LLO_RS11520 bifunctional GTP hydrolyzing adenylosuccinate UMP kinase: pyrH dependent pyruvate degradation IV LLO_RS04165 a [DNA]- 2,6-diamino-4- a ribonucleoside LLO_RS16255 6 β-D-ribosyl)-ATP LLO_RS05635 5-phosphate adenosine ubiquinone- synthase: iolC a 5'-phospho- a peptide with an N - oleate cysteine residues protein: IscStype subfamilyI diphosphokinase/ carbamoyl- synthase: dehydrogenase: poxB nucleotide- hydroxy-5-(N-methyl) 4-oxo-2-pentenal 5'-monophosphate oligodeoxyribonucleotide a proteinogenic site in DNA dependent pyruvate hisF hisH 5-dehydro-2-deoxy-D- [DNA] an N-terminal a [ThiI sulfur- methyladenine a metal a metal bifunctional L-aspartyl-4-phosphate LLO_RS10985 cysteineglutamate- glutamate-5- guanosine-3',5'-bis phosphoribosylamine- phosphate LLO_RS13695 UDP ala gly 3'-phosphate formamidopyrimidine a tRNA amino acid RS17665 adenosine deaminase: ubiquinone- dehydrogenase: poxB gluconate 6-phosphate L-proline ala carrier protein]- in DNA cation cation phosphoribosyl- D-ala desulfurase:-ammonia anthranilate PRPP semialdehyde pyrophosphate 3'- bifunctional GTP -glycine ligase: purD synthase [+ 7 isozymes] containing a LLO_RS13910 nucleoside- dependent pyruvate alanine L-glutamate L-phenylalanine S-sulfanyl- AMP aspartate- LLO_RS11720ligase: glnA dehydrogenase: pyrophosphohydrolase: spoT diphosphokinase/ acetaldehyde L-glutamate glu 3' CCA end small adenylo-succinate adenosine deaminase: diphosphate kinase: ndk dehydrogenase: poxB dehydrogenase: degradation I L-cysteine cyclohydrolase/ semialdehyde glnala LLO_RS16140 guanosine-3',5'-bis degradation IX (via degradation anthranilate GTP diphosphokinase: relA GAR subunit: carA LLO_RS15655 UTP LLO_RS16155 a metal a metal phosphoribosyl- dehydrogenase: pyrophosphate 3'- 4-aminobutanoate) I (aerobic) RS12760 phosphoribosyltransferase: trpD L-glutamate-5- carbamoyl- adenylosuccinate [+ 2 isozymes] glu a 7,8-dihydro- a DNA containing a mature a [protein chain a peptidoglycan cation cation ATP LLO_RS03015 pyrophosphohydrolase: spoT phosphoribosylglycinamide CTP synthase: acetoin L-asparagine a heme(III)-bound Nα,Nε-diacetyl-lysyl- a nucleoside an L-cysteinyl- semialdehyde phosphate lyase: purB inosine pyruvate phe DHAP 3-oxopropanoate 8-oxoguanine β Ala NAD-glutamate glu degradation I a CcmAB complex an apurinic/ peptidoglycan (R)- -lysine elongation factor dimer (S. aureus) RNA a glycyl-[tRNA ] Cys diphosphatase formyltransferase: purN LLO_RS05335 CcmCDE complex (n) D-alanyl-D-alanine triphosphate [tRNA ] dADP L-aspartate 4- synthase phenylalanine 4- in DNA apyrimidinic site 34 HisIE: N-(5-phosphoribosyl)-anthranilate L-asparagine dehydrogenase: glutamate (meso-DAP EF-P]-L-lysine semialdehyde large CTP Respiration monooxygenase: ribonucleotide- a metal a metal LLO_RS06680 biosynthesis II FGAR AMP purine-nucleoside LLO_RS09205 decarboxylase: containing) RS01620 GTP ppGpp asn LLO_RS13470 penicillin- penicillin- diphosphate cation cation 4-hydroxy- phosphoribosylanthranilate subunit: carB phosphorylase: [+ 2 isozymes] LLO_RS15130 bifunctional DNA- cytochrome c DNA- D-tyrosyl- 1-(5-phospho-β- (S)-1-pyrroline- tyr endonuclease elongation binding binding aminoacyl- reductase: tetrahydrodipicolinate isomerase: LLO_RS05990 phosphoribosylformylglycinamidine LLO_RS09110 pyrimidine ribonucleosides salvage I 2-oxoglutarate decarboxylation to succinyl-CoA 2-oxoglutarate 4-aminobutanoate asparaginase: directed RNA D-ribosyl)-AMP acetyl-CoA formamidopyrimidine biogenesis heme- III: nth lytic murein factor P--(R) protein protein tRNA(Tyr) tRNA LLO_RS07370 synthase: LLO_RS03225 5-carboxylate asp synthase subunit PurL: purL carbamoyl adenylate ansA polymerase: 1-(2-carboxyphenylamino)-1- asp glycosylase/ transporting bifunctional DNA- transglycosylase -beta-lysine 2: mrdA deacylase: hydrolase: a metal a metal (2S,4S)-4- pyrroline-5- aspartate-- bifunctional GTP kinase: adk hypoxanthine a [2-oxoglutarate 2: mrdA LLO_RS07375 RS01720 bifunctional deoxy-D-ribulose 5-phosphate phosphoribosylformylglycinamidine phosphate cytidine asp DNA-(apurinic ATPase B: mltB ligase: epmA rpoB rpoC LLO_RS05405 pth hydroxy-2,3,4,5- carboxylate ammonia ligase: diphosphokinase/ formamidopyrimidine [+ 2 isozymes] [+ 2 isozymes] ADP cation cation phosphoribosyl- synthase I: purQ dehydrogenase or apyrimidinic CcmA: ccmA [+ 3 isozymes] indole-3-glycerol LLO_RS03550 guanosine-3',5'-bis 6 glycosylase/ [+ 2 isozymes] AMP tetrahydrodipicolinate reductase: hypoxanthine-guanine E2 protein] N phosphate asn aspartate ADP uridine kinase: nucleoside site) lyase: mutM 4-hydroxy- proC pyrophosphate 3'- bifunctional GTP FGAM phosphoribosyltransferase: -lipoyl-L-lysine DNA-(apurinic [a protein chain a peptidoglycan cyclohydrolase/ carbamoyltransferase LLO_RS00065 deaminase: Nα,Nε-diacetyl- Ala Cys tetrahydrodipicolinate synthase TrpC: trpC pyrophosphohydrolase: spoT diphosphokinase/ 2-oxoglutarate or apyrimidinic a mature GlcNAc-1,6- elongation factor with D,D cross- D-ala a tRNA gly cys a tRNA a metal RS09005 a metal phosphoribosyl- catalytic subunit: LLO_RS08140 uridine LLO_RS12780 a heme(III)-bound lysyl-D-alanine D-ala RNA reductase: GTP diphosphokinase: relA guanosine-3',5'-bis phosphoribosylformylglycinamidine ribonucleotide- dehydrogenase 2-oxoglutarate a [DNA]- a CcmABCD complex site) lyase: mutM peptidoglycan anhMurNAc- EF-P]-N-(β-L- link (S. aureus) cation cation ATP (1S,2R)-1-C-(indol-3- pro nucleoside- a 5'-phospho- 7,8-dihydro- CcmE protein (n) L-arginine biosynthesis I (via L-ornithine) LLO_RS13880 kinase: udk cytidine nucleotide- 4-oxo-2-pentenal γ 34 LLO_RS16510 yl)glycerol 3-phosphate diphosphate kinase: ndk pyrophosphate 3'- cyclo-ligase: LLO_RS16540 diphosphate E1 component: dehydrogenase [DNA] 8-oxoguanine (meso-DAP L-Ala- -D-Glu- lysyl)-L-lysine diphosphatase IMP deaminase: cdd pyrophosphohydrolase: spoT reductase: LLO_RS02045 E1 component: 3'-phosphate containing) DAP-D-Ala HisIE: (S)-2,3,4,5- tryptophan synthase: CMP a 3'-terminal a 5'-phospho- a metal a metal GDP AIR N-carbamoyl- LLO_RS07370 dihydrolipoyl LLO_RS02045 2-methylcitrate Carboxylate Degradation RS10455 LLO_RS06680 tetrahydrodipicolinate glu trpB LLO_RS06000 uridine pyruvate fermentation unsaturated sugar [DNA] cation cation L-alanine L-aspartate LLO_RS07375 dehydrogenase: cycle I 2-hydroxypenta- 1-(5-phospho-β-D-ribosyl)- 2,3,4,5- 5-(carboxyamino) a [2-oxoglutarate a [2-oxoglutarate to acetate IV ser biosynthesis II uridine kinase: lpdA 2,4-dienoate 5-[(5-phosphoribosylamino) tetrahydropyridine- indole imidazole dihydroorotase: dehydrogenase dehydrogenase dADP propanoate degradation a 3-methyl- 2445 LLO_RS00065 an (S)-2- + a guanine phosphoenol methylideneamino]imidazole- 2,6-dicarboxylate N- ribonucleotide 6 6 pyruvate (2Z)-2- 34 H O 2-oxoglutarate NADPH NAD a D-tryptophanyl- an L-asparaginyl- pyrC E2 protein] N E2 protein] N -S- a 5,10- a uridine diphosphate 2 β 2+ 2+ pyruvate gly branched Trp (R)- -lysine EF-P Asn a protein Fe RS02010 Fe 4-carboxamide succinyltransferase: uridine hydroxypenta- halocarboxylate in 23S rRNA dGDP pyruvate [tRNA ] [tRNA ] alanine mutase: purE superpathway of pyrimidine deoxyribonucleoside salvage -dihydrolipoyl- succinyldihydrolipoyl- methylenetetrahydrofolate in tRNA 2,3,4-saturated bifunctional N-acetyl-L- tryptophan synthase: nucleoside- kinase: udk 2,4-dienoate ATP- 1-(5-phosphoribosyl) dapD asp (S)-dihydroorotate L-lysine L-lysine fatty acyl-CoA glutamate trpB LLO_RS06000 transaminase: CAIR diphosphate 23S rRNA dependent -5-[(5- N-succinyl-2-amino- 2'-deoxycytidine UMP RdgB/HAM1 family non- HAD family NAD(P)(+) (guanine(2069)-N(7) alaC kinase: ndk (S)-4-hydroxy- tRNA uridine-5- D-tyrosyl- elongation aminoacyl- protease a reduced phosphoribosylamino) 6-ketopimelate quinone- propanoyl-CoA phytanoyl-CoA hydrolase: transhydrogenase ala carboxymethylaminomethyl(34) canonical purine NTP )-methyltransferase pyruvate tRNA(Tyr) factor P--(R) tRNA subunit H O c-type methylideneamino] dependent pyruvate decarboxylation to acetyl CoA I 2-oxopentanoate dioxygenase: LLO_RS11285 (Re/Si-specific): 2 trp phosphoribosylaminoimidazolesuccinocarboxamide nucleoside acetyl-CoA formate synthesis GTPase MnmE: mnmE pyrophosphatase: rdgB RlmK/23S rRNA deacylase: -beta-lysine hydrolase: HslV: hslV cytochrome cytochrome imidazole-4- dihydroorotate dATP 2-oxoglutarate 2-methylcitrate 4-hydroxy-2- LLO_RS12950 LLO_RS12540 kinase: pyk an oxidized synthase: LLO_RS16550 deaminase: inorganic haloacid (guanine(2445)-N(2) LLO_RS05405 ligase: epmA pth c oxidase carboxamide isomerase: N-acetylglutamyl- dehydrogenase: dehydrogenase synthase: prpC bifunctional enoyl- a [pyruvate dehydrogenase oxovalerate tRNA uridine-5- phytanoyl-CoA LLO_RS12545 a peptide O c-type LLO_RS12780 pyruvate dehalogenase 2 Aromatic Compound Biosynthesis dCMP 6 diphosphatase: ppa )-methyltransferase LLO_RS06690 N-succinyl-L,L-2,6- phosphate LLO_RS05530 E1 component: CoA hydratase/ E2 protein] N -lipoyl-L-lysine pyruvatedehydrogenase aldolase: carboxymethylaminomethyl(34) dioxygenase: LLO_RS12550 arsenite RS16245 arsenitecytochrome cytidine (2S,3S)-2- type II: RlmL: rlmKL diaminopimelate SAICAR (d)CMP kinase: phosphate synthesis enzyme MnmG: mnmG 2 protein chain hydrogencarbonate PRPP LLO_RS02045 methylcitrate (acetyl-transferring) LLO_RS01885 LLO_RS16290 LLO_RS11545 an N - pyruvate phosphoribulosylformimino- orotate deaminase: dGTP Trp Asn chorismate biosynthesis I LLO_RS09180 acetyltransferase: methylguanine 2445 D-tryptophan a tRNA elongation factor asn tRNA succinyl- 2-oxoglutarate , homodimeric H + a 2-hydroxy-3- AICAR-phosphate dipicolinate biosynthesis adenylosuccinate cdd bifunctional 2- dihydrolipoyl acetaldehyde phosphate + β glutamine- superpathway of L-serine LLO_RS11995 34 NADH in 23S rRNA EF-P, -lysyl-Lys34 diaminopimelate dCDP dehydrogenase type: aceE a 5-carboxymethylaminomethyluridine methyl-branched succinate NADP N-acetyl-L- hydrolyzing and glycine biosynthesis I D-erythrose lyase: purB orotate methylcitrate dehydrogenase: lpdA a 7,8-dihydrofolate a (2R)-2- desuccinylase: complex pyruvate in tRNA 2,3,4-saturated a halide anion imidazole glutamate 5- carbamoyl- 4-phosphate phosphoribosyltransferase: 2'-deoxyuridine nucleoside- dehydratase/ acetyl phosphate hydroxy fatty acid dapE 3-phospho- 3-deoxy-7- asp AICAR dihydrolipoyllysine- dehydrogenase fatty acyl-CoA glycerol semialdehyde phosphate pyrE diphosphate aconitate N-acetylornithine D-glycerate phosphoheptulonate bifunctional aspartate thymidine residue (acetyl-transferring) phosphate L,L-diaminopimelate synthase phosphoglycerate bifunctional kinase: ndk hydratase: acetate/propionate aminotransferase: synthase: kinase/diaminopimelate kinase: succinyltransferase: LLO_RS07965 E1 component acetyl-CoA synthase: small dehydrogenase: phosphoribosylaminoimidazolecarboxamide orotidine 5'- family kinase: a purine base a reduced an N-formyl-L- a 2'- DNA with adenine:7,8- a guanine 2069 phosphoenol a mismatched LLO_RS00330 LLO_RS12715 decarboxylase: LLO_RS00135 dCTP odhB a [pyruvate dehydrogenasesubunit alpha: pdhA ubiquinone-6 hisF hisH phosphate cis-2- LLO_RS11990 a [pyruvate dehydrogenase E2 6 electron-transfer methionylaminoacyl- deoxyribonucleoside dihydro-8- glu ala diaminopimelate subunit: carA LLO_RS15985 LLO_RS05635 formyltransferase/IMP cyclohydrolase: purH thymidine E2 protein] N -S- lesion in DNA [DNA] in 23S rRNA dADP pyruvate DNA base pair GTP GMP 3-deoxy-7- 6 dihydrolipoyllysine- oxidized N-acetyl-L- 3-phosphoglycerate superpathway of methylaconitate protein] N -dihydrolipoyl-L-lysine flavoprotein tRNA 5'-triphosphate oxoguanine mismatch bifunctional DNA mismatch epimerase: dapF carbamoyl- L-aspartyl-4-phosphate orotidine-5'- dUMP acetate acetyldihydrolipoyl-L-lysine factor 420-2 D-erythro-1- ornithine phosphoheptulonate FAICAR residue 23S rRNA repair guanosine AICAR phosphate dehydrogenase: phosphate guanosine nucleotides thymidine bifunctional DNA- (imidazol-4- synthase: acetyltransferase: electron transfer (guanine(2069)-N(7) protein MutS: monophosphate acetylornithine synthase LLO_RS03750 bifunctional decarboxylase: de novo biosynthesis I kinase: 2-oxoisovalerate decarboxylation to isobutanoyl-CoA formamidopyrimidine peptide DNA A/G-specific glutamate- yl)-glycerol meso-diaminopimelate 3-deoxy- LLO_RS06830 aspartate-semialdehyde thymidylate guanine and aceF superpathway of acetate flavoprotein- LLO_RS03000 coenzyme F390 reductase: deacetylase: 3-phosphooxypyruvate LLO_RS00135 deformylase: polymerase adenine )-methyltransferase pyruvate -cysteine 3-phosphate large dehydrogenase: phosphoribosylaminoimidazolecarboxamide pyrF synthase: (2R,3S)-2- utilization and formation glycosylase/ ubiquinone LLO_RS01055 D-arabino- guanosine salvage II an [apo BCAA def III subunit chi: glycosylase: RlmK/23S rRNA DNA synthetase: ligase: gshA bifunctional argE subunit: carB LLO_RS03015 formyltransferase/IMP cyclohydrolase: purH IMP methylisocitrate DNA-(apurinic kinase: pyk bifunctional 3-phosphoserine/ heptulosonate UMP thyA dehydrogenase E2 oxidoreductase: LLO_RS13380 mutY (guanine(2445)-N(2) mismatch LLO_RS02810 IMP aspartate kinase/ alpha-ketoacid mevalonate degradation acetate or apyrimidinic peptide [+ 2 isozymes] histidinol- carbamoyl phosphohydroxythreonine 7-phosphate 6 acetate- LLO_RS05855 )-methyltransferase diaminopimelate L-ornithine L-aspartate 4-semialdehyde UMP IMP guanosine protein] N -lipoyl-L-lysine dehydrogenase site) lyase: mutM deformylase: [+ 15 isozymes] repair protein phosphatase/ phosphate transaminase: serC 3-dehydroquinate IMP methylisocitrate -CoA RlmL: rlmKL MutS: mutS decarboxylase: kinase: dehydrogenase: subunit beta: acetyl-CoA acetate/ def an apurinic site an N 7 - pyruvate γ imidazoleglycerol- synthase: lyase: prpB (R)-mevalonate ligase: acs an oxidized a properly matched coenzyme F -G -L-glutamyl- LLO_RS05635 O-phospho- 4-hydroxy- pyrH guaB LLO_RS07770 propionate H + methylguanine 2069 dATP 390 phosphate LLO_RS04520 a [DNA]- electron-transfer ubiquinol-6 adenine within DNA DNA base pair D-alanine ornithine L-isoleucine L-serine tetrahydrodipicolinate family kinase: a 5'-phospho- a modified [DNA] dehydratase UDP dTMP alpha-ketoacid hydroxymethylglutaryl-CoA nucleotide- 4-oxo-2-pentenal flavoprotein in 23S rRNA lys carbamoyltransferase: biosynthesis IV pyruvate succinate LLO_RS11990 [DNA] nucleobase a L-methionylaminoacyl- HisB: hisB phosphoserine 3-dehydroquinate synthase: LLO_RS03225 IMP XMP guanine dehydrogenase reductase, degradative: 3'-phosphate formate argF nucleoside- dTMP kinase: tRNA 3-(imidazol-4- phosphatase: (2S,4S)-4-hydroxy-2,3,4,5- dehydrogenase: subunit LLO_RS10660 acetyl phosphate acetyl-CoA propanoate diphosphate LLO_RS07615 dihydrolipoyl yl)-2-oxopropyl LLO_RS03755 type II 3- tetrahydrodipicolinate guaB glutamine- hypoxanthine-guanine alpha/beta: kinase: ndk dehydrogenase: HMG-CoA phosphate dehydroquinate hydrolyzing GMP dTDP phosphoribosyltransferase: LLO_RS03295 asp L-citrulline gln lpdA an [apo BCAA dehydrogenase a [ribosomal an sn-glycero-3- a 2'- a [protein]-L- (S)-1-pyrroline- an unstable ser dehydratase: aroQ an [apo BCAA 6 an N-terminal an L-phenylalanyl- 34 histidinol- UTP synthase: guaA nucleoside- LLO_RS08140 E2 protein] N -S-[2- a sulfurated deoxyribonucleoside γ-L-glutamyl-(S)- H O glutamate-O 5 a cytidine RecA filament- protein S12] Phe phospho-N-(acyl) [DNA] gly 2 5-carboxylate lys dehydrogenase E2 protein] arginyl-[protein] GTP ATP Ile2 propanoyl-CoA hydroxymethylglutaryl- [sulfur carrier] 89 [tRNA ] oxidized phosphate 3-dehydroshikimate GMP synthase: diphosphate 6 methylpropanoyl]dihydrolipoyl- L-aspartate 5'-triphosphate 2-aminobutanoate -methyl-ester bifunctional in tRNA DNA complex L-homoserine serine dipicolinate XMP N -dihydrolipoyl-L-lysine bifunctional enoyl- ethanolamine DNA transaminase: argininosuccinate CTP synthase: LLO_RS05700 kinase: ndk GMP L-lysine CoA lyase: LLO_RS05490 proline factor 420-2 biosynthesis 2-oxoacid:ferredoxin hydroxymethyltransferase: CoA hydratase/ repair hisC synthase: shikimate LLO_RS05335 leucyl/ dehydrogenase/L- oxidoreductase LLO_RS04245 glutamine- dTTP phosphate 30S ribosomal glycerophosphoryl DNA glutathione chemotaxis-specific tRNA protein LLO_RS11575 dehydrogenase: GMP xanthine and elongation glutamate gamma- histidinol- subunit beta: acetoacetate acetyl-CoA phenylalanyl- polymerase synthetase: protein-glutamate coenzyme F390 lysidine(34) RecO: asp aroE hydrolyzing CTP xanthosine salvage acetyltransferase: protein S12 diester factor 4: lepA phosphate gly tRNA--protein semialdehyde synthetase: bifunctional LLO_RS09930 GMP LLO_RS11995 methylthiotransferase phosphodiesterase: III subunit chi: LLO_RS17480 [+ 6 isozymes] methyltransferase synthetase a stabilizedrecO transaminase: L-arginino- NADH repair (prokaryotes) transferase: dehydrogenase LLO_RS02810 aspartate kinase/ shikimate synthase: guanylate 2-oxo acid RimO: rimO LLO_RS17065 LLO_RS13380 glutathione CheB: cheB TilS: tilS RecA filament- succinate 2-oxobutanoate LLO_RS11810 PutA: putA LLO_RS06905 diaminopimelate guaA kinase: gmk xanthosine dehydrogenase [+ 14 isozymes] DNA complex asp glycerophosphodiester synthase: gshB + argininosuccinate shikimate pyrimidine deoxyribonucleotides subunit E2: phosphate H L-histidinol decarboxylase: GMP synthase: purine-nucleoside NADH a [ribosomal α glu 34 acetolactate kinase guanine and phosphodiesterase: ugpQ GDP a [protein]- - coenzyme F -A a lysidine phosphate LLO_RS05635 lyase: argH de novo biosynthesis I phosphorylase: LLO_RS07765 5'-deoxyadenosine an unsulfurated L-phenylalanyl-L- MeOH 390 Ile2 synthase LLO_RS05700 met protein S12]-3- Phe L-glutamate in tRNA L-aspartyl- AroK: aroK adenylosuccinate guanosine salvage GDP [sulfur carrier] arginyl-[protein] a tRNA [DNA] large subunit: UDP CTP LLO_RS09110 methylsulfanyl- ophthalmate bifunctional 4-phosphate synthase: xanthine sn-glycerol an N- arg glycine biosynthesis II shikimate 3- ribonucleotide- L-aspartate 89 histidinol- LLO_RS15860 GMP LLO_RS13695 acylethanolamine phosphate guanosine diphosphate 3-phosphate phosphatase/ aspartate- (S)-2-aceto-2- a [glycine-cleavage nucleoside- 3-phosphoshikimate 1- adenylo-succinate purine-nucleoside ribonucleotide- reductase: CDP (R)-NADHX Fatty Acid and Lipid Degradation imidazoleglycerol- semialdehyde hydroxybutanoate complex H protein] N 6 - diphosphate carboxyvinyltransferase: guanylate phosphorylase: diphosphate LLO_RS07370 bifunctional phosphate dehydrogenase: ribonucleotide- Glycolysis 34 7,8- a peptide with aminomethyldihydrolipoyl- kinase: gmk kinase: ndk reductase: a 5,10- a 2-thiouridine an N-terminal a D-aminoacyl- (S)-2- pyridoxamine LLO_RS03015 aroA adenylosuccinate LLO_RS09110 LLO_RS07375 diphosphate ADP-dependent β an L-phenylalanyl- glycerophosphoserine dihydroneopterin detyrosinated tyr an N-terminal roseoflavin dehydratase L-lysine oleate -oxidation in tRNA Phe glu 5-enolpyruvoyl- guanine LLO_RS07370 XMP NAD(P)H-hydrate fatty acid β-oxidation I (generic) methylenetetrahydrofolate L-lysyl-[protein] [tRNA ] [tRNA] aminobutanoate α-tubulin ATP 5'-phosphate HisB: hisB lyase: purB dUDP reductase: 3'-triphosphate L-methionine bifunctional L-aspartate 4- glycine cleavage glycine cleavage shikimate 3- LLO_RS07375 glycolysis III (from glucose) RNA pyridoxamine (R)-2,3-dihydroxy- gly GDP LLO_RS07370 dehydratase/ riboflavin semialdehyde system protein system protein phosphate GTP nucleoside- oleate a (3Z)-alk-3- 5'-phosphate histidinol 3-methylpentanoate hypoxanthine-guanine LLO_RS07375 NAD(P)H-hydrate tRNA uridine-5- leucyl/ glycerophosphoryl kinase/FAD T: LLO_RS07685 T: LLO_RS07685 AMP diphosphate D-glucopyranose enoyl-CoA 6-pyruvoyl D-tyrosyl- glutamate- tubulin-- type I methionyl oxidase: chorismate phosphoribosyltransferase: epimerase: carboxymethylaminomethyl(34) phenylalanyl- diester polynucleotide synthetase: [+ 4 isozymes] kinase: ndk dCDP tetrahydrobiopterin tRNA(Tyr) -cysteine tyrosine ligase: aminopeptidase: LLO_RS13570 histidinol [+ 2 isozymes] synthase: LLO_RS08140 dGDP LLO_RS01820 synthesis GTPase MnmE: mnmE tRNA--protein phosphodiesterase: adenylyltransferase ribF a [glycine-cleavage a [glycine-cleavage glucokinase: (S)-NADHX synthase: deacylase: ligase: gshA LLO_RS11195 map pyridoxamine dehydrogenase: aroC adenylate dUTP nucleoside- tRNA uridine-5- LLO_RS17065 roseoflavin complex H protein] N 6 6 glk transferase: LLO_RS00900 PcnB: pcnB hisD (3S)-3-methyl-2- complex H protein] N ribonucleotide- GMP nucleoside- LLO_RS05405 [+ 2 isozymes] 5'-phosphate L-homoserine -dihydrolipoyl-L-lysine kinase: adk dUTP diphosphate bifunctional oleoyl-CoA carboxymethylaminomethyl(34) LLO_RS11810 glycerophosphodiester 5'-phosphate oxopentanoate -[(R)-lipoyl]-L-lysine chorismate diphosphate diphosphate D-glucopyranose a (2E)-2- oxidase: pdxH histidinal diphosphatase: dut kinase: ndk ADP-dependent synthesis enzyme MnmG: mnmG phosphodiesterase: ugpQ tyrosinated reductase: nucleoside- kinase: ndk 6-phosphate enoyl-CoA (6R)-6-pyruvoyl- γ met a peptide PLP nucleoside triphosphate NAD(P)H-hydrate acyl-CoA 3-hydroxyacyl- an uncharged -L-glutamyl-(S)- α-tubulin RNA LLO_RS07370 diphosphate ADP dCTP L-phenylalanyl- 5,6,7,8- triphosphate a D-amino acid histidinol glucose-6- dehydratase/ dehydrogenase: CoA epimerase: a 2,3,4- a tRNA Phe tRNA 2-aminobutanoate pyrophosphohydrolase: enoyl-CoA a 5-aminomethyl-2- L-lysyl-[protein] tetrahydropterin dehydrogenase: LLO_RS07375 kinase: ndk dGTP phosphate saturated (3R)-3- a 7,8-dihydrofolate sn-glycerol LLO_RS01330 NAD(P)H-hydrate LLO_RS04575 a 2,3,4-saturated acyl-CoA hydratase: LLO_RS09265 34 ser ribonucleotide- isomerase: pgi thiouridine in tRNA 3-phosphate hisD ile glycine cleavage epimerase: [+ 5 isozymes] LLO_RS04580 hydroxyacyl-CoA dUMP fatty acid dehydrogenase: diphosphate LLO_RS01820 system protein CMP F6P (2E,9Z)- LLO_RS11480 a 2,3,4- his T: LLO_RS07685 reductase: thymidylate a 2,3,4-saturated LLO_RS07370 phosphorylation octadecenoyl-CoA [+ 5 isozymes] saturated (3S)-3- UDP-N-acetyl-α-D-muramoyl- a 1-acyl-2- an N-terminal- (3R,5S)-3- [+ 3 isozymes] synthase: thyA NADH fatty acyl CoA di-trans,octa-cis- sn-glycero-3-phospho-N- sn-glycero-3- an N-modified dGDP enoyl-CoA hydroxyacyl-CoA L-alanyl-γ-D-glutamyl-L- arachidonoyl- a RNA-DNA hybrid L-methionyl-L- NADH carbonic acid LLO_RS07375 CMP undecaprenyl phosphate (arachidonoyl)ethanolamine phosphoethanolamine aminoacyl-[tRNA] dITP hydroxy-1- dTMP hydratase: 3-hydroxyacyl-CoA lysyl-D-alanyl-D-alanine sn-glycerol alanyl-[protein] pyrroline-5- GTP (d)CMP kinase: acetyl-CoA C- RdgB/HAM1 family non- dADP β-D-fructose 1,6- LLO_RS04580 dehydrogenase: 3-phosphate CTP carboxylatepyrroline-5- LLO_RS09180 dTMP kinase: acyltransferase: glycerophosphodiester glycerophosphoryl ribonuclease canonical purine NTP NAD(+) carbonic Carbohydrate Biosynthesis nucleoside- CDP bisphosphate (S)-3-hydroxy-(9Z) coenzyme A LLO_RS11835 phospho-N- type I methionyl carboxylate LLO_RS07615 LLO_RS05515 phosphodiesterase: ugpQ diester aminoacyl- HII: rnhB pyrophosphatase: rdgB diphosphatase: anhydrase: diphosphate nucleoside- -octadecenoyl-CoA a 2,3,4-saturated a 2,3,4-saturated acetylmuramoyl- phosphatidate tRNA aminopeptidase: reductase: nucleoside- dTDP acetyl-CoA C- glycerophosphoryl diester phosphodiesterase: ribonuclease nucleoside triphosphate nudC LLO_RS12935 gluconeogenesis I kinase: ndk diphosphate fructose- 3-hydroxyacyl-CoA fatty acyl CoA 3-oxoacyl-CoA pentapeptide- cytidylyltransferase: hydrolase: map proC diphosphate acyltransferase: phosphodiesterase: LLO_RS17065 HI: rnhA [+ 3 isozymes] GDP-L-fucose biosynthesis GDP-mannose biosynthesis CMP-3-deoxy-D- kinase: ndk nucleoside- bisphosphate dehydrogenase: Alcohol Degradation transferase: pyrophosphohydrolase: Hyp kinase: ndk LLO_RS13645 pth reduced β- I (from GDP-D-mannose) manno-octulosonate diphosphate aldolase class I: LLO_RS09265 LLO_RS11830 LLO_RS13990 LLO_RS17065 glycerophosphodiester LLO_RS01330 Fatty Acid and Lipid Biosynthesis (S)-malate an N-terminal L- nicotinamide D- GDP-α-D- D-glucopyranose biosynthesis CTP kinase: ndk LLO_RS13775 glycerol and glycerophosphodiester degradation phosphodiesterase: ugpQ dIMP AMP D-ribulose dGTP dATP 3-hydroxyacyl-CoA a CDP-1-acyl- DNA a nucleoside 5'- met alanyl-[protein] ribonucleotide CO H O 6-phosphate an uncharged 2 2 mannose dTTP dehydrogenase: undecaprenyl-diphospho-N- 2-arachidonoyl- an N-modified monophosphate palmitate biosynthesis GDP- glucose-6- 5-phosphate UMP anandamide sn-glycerol 3-phosphate tRNA octanoyl-[acyl-carrier D-arabinose γ glycerol amino acid (type II fatty acid synthase) phosphatidylglycerol cyclopropane mannose 4,6- phosphate triose- LLO_RS11835 glycerol a glycerophosphodiester acetylmuramoyl-L-alanyl- -D- ethanolamine sn-glycerol protein] biosynthesis 5-phosphate acetyl-CoA biosynthesis I (plastidic) fatty acid (CFA) malate dehydratase: isomerase: pgi phosphate 3-oxo-(9Z)- glutamyl-L-lysyl- D-alanyl-D-alanine 3-phosphate isomerase: (mitochondria, yeast) biosynthesis dehydrogenase: F6P an acetoacetyl-[acp] malate gmd isomerase: octadecenoyl-CoA DHAP a [phospholipid] cis LLO_RS12985 GDP-4-dehydro- aldehydoLLO_RS10310-D- glycerophosphoryl dehydrogenase: α LLO_RS01405D-glyceraldehyde acetyl-CoA C- an N-terminal- an acetoacetyl-[acp] glycerol-3- -olefinic fatty acid -D-rhamnose mannose-1-phosphate arabinose 5- DHAP diester UDP-N-acetyl-α-D- UDP-N-acetylmuramoyl-L- 7,8-dihydrofolate a 2'- an N-terminal- a [protein]-L- 3-oxoacyl- 3-oxoacyl-ACP cyclopropane LLO_RS02210 malate 3-phosphate acyltransferase: di-trans,octa-cis- NADPH H + an adenosine 37 L-methionyl-L- N-acetyl- phosphate GDP-L-fucose guanylyltransferase/ phosphate C1 Compound Utilization and Assimilation glycerol phosphodiesterase: muramoyl-L-alanyl-γ-D- alanyl-γ-D-glutamyl-meso-2,6- monoglutamate DMAPP deoxyribonucleoside L-methionyl-L- methionine dehydrogenase: LLO_RS11830 undecaprenyl phosphate in tRNA [DNA] XTP L-citrulline GTP ACP reductase dehydrogenase: fatty acyl synthase: mannose-6- type I LLO_RS17065 glutamyl-L-lysyl-D-alanine diaminopimeloyl-D-alanine 5'-triphosphate threonyl-[protein] seryl-[protein] bifunctional reductase FabG: fabG phospholipid LLO_RS14435 phosphate isomerase: Storage Compound Biosynthesis RdgB/HAM1 family non- a (3R)-3- LLO_RS02980 LLO_RS16030 glyceraldehyde- acetyl-CoA C- glycerol kinase glycerophosphodiester methionine diguanylate FabG: fabG formaldehyde oxidation dihydrofolate canonical purine NTP sn-glycerol a [phospholipid]synthase: cfa GDP-4-dehydro- LLO_RS01025 Secondary Metabolite Biosynthesis 3-phosphate acyltransferase: formaldehyde oxidation tRNA (adenosine(37)-N6) reverse type I methionyl type I methionyl acetylornithine sulfoxide cyclase: a (3R)-3- hydroxybutanoyl-[acp] VII (THF pathway) GlpK: glpK phosphodiesterase: ugpQ phospho-N- LD-carboxypeptidase: reductase: 3-phosphate fatty acid containing β D-arabinofuranose cyanophycin metabolism dehydrogenase: LLO_RS05515 -dimethylallyltransferase pyrophosphatase: rdgB reductase LLO_RS07080 6-deoxy- - mannose-1-phosphate polyhydroxybutanoate biosynthesis II (glutathione-dependent) acetylmuramoyl- LLO_RS02355 transcriptase: aminopeptidase: aminopeptidase: deacetylase: hydroxybutanoyl- 3-hydroxyacyl- cyclopropane pyruvate 5-phosphate gap LLO_RS18665 nucleoside triphosphate glycerol-3- L-galactose guanylyltransferase/ formaldehyde pentapeptide- LD-carboxypeptidase: MiaA: miaA LLO_RS09610 map map argE B/A protein: [+ 4 isozymes] [acp] ACP dehydratase oxaloacetate 3-deoxy-8- fluoroacetate and (7Z)-hexadecenoyl-CoA sn-glycerol 3-phosphate dihydrofolate pyrophosphohydrolase: phosphate 1-O- GDP-L-fucose mannose-6- preQ biosynthesis myo-inositol formaldehyde transferase: [+ 2 isozymes] LLO_RS00715 c-di-GMP 3-hydroxyacyl- FabZ: fabZ fluorothreonine biosynthesis 0 asp LLO_RS03860 a protein-L- phosphooctulonate biosynthesis acetyl-CoA 13-DPG reductase: 6 LLO_RS01330 acyltransferase phosphoenolpyruvate synthase: phosphate isomerase: acyl-CoA LLO_RS13990 N -(3-methylbut- methionine- ACP synthase: kdsA LLO_RS02410 an N-terminal L- an N-terminal PlsY: plsY LLO_RS16030 LLO_RS15910 dehydrogenase: a 5,10- glycerol-3-phosphate 2-en-1-yl)- XMP acetate fluoride RS15430 fluoride dehydratase a (2E)-but-2-enoyl-[acp] synthase: ppsA fluoride D-glucopyranose cyanophycin acetyl-CoA C- UDP-N-acetyl-α-D-muramoyl- met threonyl-[protein] met L-seryl-[protein] L-citrulline (S)-S-oxide a 1-acyl-sn phosphoglycerate S-(hydroxymethyl) dehydrogenase: glpD 37 FabZ: fabZ acyl-CoA hydrolysis D-mannopyranose GTP 6-phosphate acyltransferase: LLO_RS04575 methylenetetrahydrofolate undecaprenyl-diphospho-N γ adenosine [DNA] -glycerol 3- GDP-β-L-fucose KDO-8P synthetase: kinase: glutathione UMP D-ala L-alanyl- -D-glutamyl- enoyl-[acyl- SAM-dependent GTP [+ 5 isozymes] γ 5,6,7,8- in tRNA 6-phosphate cphA LLO_RS11830 bifunctional -acetylmuramoyl-L-alanyl- - meso-2,6-diaminopimelate + a (2E)-but- phosphate a 2,3,4-saturated phosphoenolpyruvate chlorinase/ LLO_RS16475 S-(hydroxymethyl) DHAP NADP carrier-protein] phosphomannomutase/ cyclohydrolase (2E,7Z)- methylenetetrahydrofolate D-glutamyl-L-lysyl- D-alanine tetrahydrofolate 2+ 2+ 2-enoyl-[acp] 1-acyl-sn-glycerol- cyanophycin [+ 2 isozymes] Zn RS15050 Zn reductase fatty acyl CoA fluorinase: 7,8- I FolE: folE Ins(3)P arg glutathione acyl-CoA phosphopyruvate phosphoglucomutase: 3-phospho-D-glycerate hexadecenoyl-CoA dehydrogenase/ 3-phosphate LLO_RS08495 dihydroneopterin primer-L-aspartate dehydrogenase/ enoyl-ACP FabL: fabL thioesterase: LLO_RS15470 acetoacetyl-CoA methenyltetrahydrofolate acyltransferase: hydratase: eno 3'-triphosphate enoyl-CoA a nascent peptidoglycan N-acetyl-D-glucosaminyl-N- (2-hydroxyphenyl) a peptidoglycan a peptide with an N-terminal- a [peptide]-with reductase: UDP-N-acetyl-D- α-Kdo 5'-deoxy-5'- inositol 2,3-bisphosphoglycerate- cyclohydrolase FolD: folD class III alcohol phytanoyl-CoA [+ 2 isozymes] LLO_RS02135 LLO_RS01100 α-D-mannose cyanophycin hydratase: (meso-DAP containing) acetylmuramoyl-L-alanyl-D-glutamyl- 2-oxoglutarate methyl 1-hydroxy- dimer (generic) an N-terminal L-methionyl-L- a C-terminal L-dopa a protein LLO_RS05360 glucosamine biosynthesis I fluoroadenosine monophosphatase: acetoacetyl- dehydrogenase: ITP Mg 2+ RS02235 Mg 2+ a 1,2-diacyl- [+ 3 isozymes] 2-phospho-D-glycerate 1-phosphate synthetase: independent LLO_RS04580 a 5,10- 6-carboxy-L-lysyl-D-alanine valyl-[protein] L-arginine a 2,3,4-saturated 3-deoxy-manno- LLO_RS11710 CoA LLO_RS12580 6-oxocyclohex-2- L-proline 4,5-DOPA endopeptidase enoyl-ACP a butanoyl-[acp] sn-glycerol D-glucopyranose purine-nucleoside phosphoglycerate methenyltetrahydrofolate RdgB/HAM1 family non- fatty acid mannose-1-phosphate octulosonate cphA reductase: (S)-3-hydroxy-(7Z) lytic murein ene-1-carboxylate lytic murein La: lon reductase 3-phosphate 2,3-bisphosphoglycerate- 6-phosphate phosphorylase: 6-carboxy-5,6,7,8- mutase: LLO_RS13655 phytanoyl-CoA canonical purine NTP dioxygenase beta-ketoacyl- glucose-6- guanylyltransferase/ cytidylyltransferase: myo-inositol phbB -hexadecenoyl-CoA bifunctional S-formylglutathione transglycosylase LD-carboxypeptidase: transglycosylase type I methionyl endopeptidase FabI: fabI phosphatidate independent LLO_RS09110 tetrahydropterin dioxygenase: prolyl pyrophosphatase: rdgB peptidase S10: extradiol: ygiD ACP synthase phosphate mannose-6- kdsB asp 2-phospho-D-glycerate 3-hydroxyacyl-CoA methylenetetrahydrofolate B: mltB LLO_RS02355 B: mltB aminopeptidase: La: lon potassium- cytidylyltransferase: phosphoglycerate 5-fluoro-5-deoxy-D- cyanophycin [+ 2 isozymes] LLO_RS16290 carboxylesterase: aminopeptidase: pip nucleoside triphosphate LLO_RS08020 4,5-DOPA + + 7-carboxy-7- dehydrogenase: dehydrogenase/ S-formylglutathione map K transporting K a butanoyl-[acp] II: fabF mutase: LLO_RS13655 isomerase: pgi phosphate isomerase: (3R)-3- [+ 2 isozymes] LD-carboxypeptidase: LLO_RS02735 [+ 3 isozymes] dioxygenase a peptide LLO_RS13645 CMP-Kdo ribose 1-phosphate deazaguanine methenyltetrahydrofolate hydrolase: fghA phytanoyl-CoA pyrophosphohydrolase: ATPase F6P LLO_RS01025 hydroxybutanoyl- poly-[(R)-3- phosphopyruvate LLO_RS09265 LLO_RS03860 a CDP- synthase QueE: dioxygenase: LLO_RS01330 extradiol: ygiD beta- a 3-oxohexanoyl-[acp] 3-phospho-D-glycerate cyanophycin CoA hydroxybutanoate] hydratase: eno 3-oxo-(7Z)- cyclohydrolase FolD: folD glutamine-- mannose-1-phosphate formate Carbohydrate Degradation a mature peptidoglycan a nascent peptidoglycan LLO_RS12950 GlcNAc-1,6- an N-terminal 4,5-seco-dopa diacylglycerol LLO_RS03745 synthetase: hexadecenoyl-CoA an N 10 - 1-hydroxy-6- a lipid II a peptide pro IMP arg a peptide ketoacyl- phosphoglycerate guanylyltransferase/ with (L-alanyl-γ-D-glutamyl- (meso-DAP containing) N-acetyl-D-glucosaminyl-N- salicyl alcohol anhydro-MurNAc- met L-valyl-[protein] chloride RS01115 chloride 3-oxoacyl-ACP phosphatidylglycerophosphate fructose-6- 7-carboxy-7- cphA class I poly(R)- phosphoenolpyruvate formyltetrahydrofolate oxocyclohex-2- ACP kinase: mannose-6- 5-fluoro-5-deoxy-D- acetyl-CoA C- meso-2,6-diaminopimeloyl- with GlcNAc terminus acetylmuramoyl-L-alanyl-D- D-ala pentapeptide reductase synthase: LLO_RS01375 phosphate deazaguanine hydroxyalkanoic Entner-Doudoroff pathway I 2-hydroxyphytanoyl- ene-1-carboxylate synthase phosphate isomerase: ribulose 1-phosphate acyltransferase: formyltetrahydrofolate D-alanine) tetrapeptide glutamyl-6-carboxy-L-lysine succinate FabG: fabG LLO_RS16475 transaminase PRPP biosynthesis arg [cyanophycin]- pyruvate D-mannose degradation II: fabF CDP-diacylglycerol-- LLO_RS15910 7-cyano-7- acid synthase: LLO_RS11830 CoA (isomerizing) L-aspartate kinase: pyk NADPH repair (prokaryotes) deformylase: purU D-glucopyranose lipid A RS05545 lipid A a (3R)-3- glycerol-3-phosphate 3- 13-DPG deazaguanine phaC D-mannopyranose a 3-oxohexanoyl- : glmS α D-ribose 5- acetyl-CoA C- 6-phosphate hydroxyhexanoyl-[acp] phosphatidyltransferase: GDP- -D-mannose synthase formate β [acp] phosphate cyanophycin pyruvate acyltransferase: 6-phosphate a [2-oxoglutarate- quinoxaline-2- a [DNA]-3'- N-acetyl- -D- an N-terminal- a protein-L- pgsA D-glucosamine ribose-phosphate QueC: queC poly-[(R)-3- NADPH glucose-6- mannose-1-phosphate a sulfurated (+)-7-epi- H O an unfolded 3-hydroxyacyl- type I fluoroacetaldehyde LLO_RS05515 SAM dehydrogenase aryl-carrier protein glu a (6S)-5- glucosaminyl-(1 asp O-ureido-L- 2 L-methionyl- a protein methionine- 3-oxoacyl- 1-(3-sn- 6-phosphate synthetase: hydroxybutanoate] phosphate guanylyltransferase/ carboxyl adenylate hydroxyl jasmonoyl-CoA protein ACP dehydratase glyceraldehyde- pyrophosphokinase: [sulfur carrier] 6 formyltetrahydrofolate homoserine glycyl-[protein] (R)-S-oxide sulfite RS04130 sulfite preQ cphA E2 protein] N - -> 4)-N-acetyl- ATP-dependent ACP phosphatidyl) 0 dehydrogenase: mannose-6- bifunctional FabZ: fabZ triose- 3-phosphate phosphoglucosamine LLO_RS02095 (5Z)-tetradecenoyl-CoA octanoyl-L-lysine β-D-muramate -sn-glycerol zwf phosphate isomerase: Clp protease chaperonin reductase phosphate dehydrogenase: mutase: glmM ribose-phosphate exodeoxyribonuclease acyl-CoA methionine 3-phosphate acyl-CoA 6-phospho LLO_RS01025 acyl carrier bifunctional argininosuccinate type I methionyl ATP-binding GroEL: groL FabG: fabG a (2E)-hex-2-enoyl-[acp] isomerase: gap α-D-glucosamine UDP-α-D-glucose diphosphokinase: cyanophycin Polymeric Compound lipoyl III: xth thioesterase: sulfoxide preQ preQ a (3R)-3- dehydrogenase: D-glucono- protein: acpP tetrahydrofolate beta-N- synthase: aminopeptidase: subunit ClpA: clpA reductase 0 0 phosphatidylglycerophosphatase (R)-NADPHX Degradation mannose-1-phosphate exodeoxyribonuclease LLO_RS00160 RS15630 LLO_RS01405 D-glyceraldehyde 1-phosphate biosynthesis LLO_RS11190 fluoroacetate bifunctional synthase: LLO_RS11575 map preQ preQ hydroxyhexanoyl- enoyl-[acyl- DHAP 4-fluorothreonine cyanophycinase: LLO_RS11480 1,5-lactone [+ 3 isozymes] synthase/ acetylhexosaminidase: ATP-dependent B/A protein: a protein 1 1 A: LLO_RS04265 PRPP guanylyltransferase/ lipA III: xth [+ 2 isozymes] 3-phosphate bifunctional UDP-N- D-glucopyranose ADP-dependent dihydrofolate nagZ [acp] carrier-protein] an L-1- LLO_RS12855 [+ 5 isozymes] glycogen degradation II 6-phosphogluconolactonase: mannose-6- Clp: clpP clpX LLO_RS00715 3-hydroxyacyl- acetylglucosamine 6-phosphate NAD(P)H-hydrate synthase: folC a [protein]-L- reductase phosphatidyl- phosphomannomutase/ β (2E,5Z)- pgl phosphate isomerase: a [2-oxoglutarate a quinoxaline-2- an N-terminal a peptide diphosphorylase/ N- -aspartyl- dehydratase/ 5'-deoxyadenosine an unsulfurated a [DNA]-3'- a 2'- canavaninosuccinate (+)-7-epi- methionine ACP FabL: fabL tetradecenoyl-CoA met dehydrogenase carboxyl-[aryl- N-acetyl-D- met glycyl-[protein] sn-glycerol phosphoglucomutase: L-arginine a glycogen D-gluconate LLO_RS15910 [sulfur carrier] AMP deoxyribonucleoside GlcNAc dehydratase glucosamine-1- NAD(P)H-hydrate E2 protein] N 6 carrier protein] hydroxyl muramate jasmonate [+ 2 isozymes] fatty acid elongation -- saturated fructose- α LLO_RS15470 6-phosphate F6P a (6S)-5- 5'-monophosphate phosphate N- -D-glucopyranose epimerase: ∆ 3 2 FabZ: fabZ -cis-∆ -trans- enoyl-CoA -lipoyl-L-lysine formyltetrahydrofolate bisphosphate acetyltransferase 1-phosphate isoaspartyl LLO_RS01820 phosphogluconate a (2E)-hex- a hexanoyl-[acp] enoyl-CoA hydratase: aldolase class I: GlmU: glmU peptidase/L- (S)-NADPHX dehydratase: 2-enoyl-[acp] an acetoacetyl-[acp] UTP--glucose- isomerase: LLO_RS04580 LLO_RS13775 N-acetyl-α-D- asparaginase: an α-limit dextrin LLO_RS14215 an [L-cysteine a [protein]- beta-ketoacyl- 1-phosphate LLO_RS09265 a 2-oxo a cytosine 32 dCDP enoyl-ACP LLO_RS12850 bifunctional glycerophosphoglycerol an alkylated DNA a peptide with a a holo [PedD acyl- propanoyl-CoA H O acetoacetate ACP synthase glucosamine carboxylate desulfurase]-S- 2 L-saccharopine L-tyrosine uridylyltransferase (S)-3-hydroxy-(5Z) trehalose degradation in tRNA leader sequence carrier protein] ribonucleotide- reductase: 1-phosphate Pentose Phosphate Pathways ADP-dependent KDGP sulfanyl-L-cysteine phosphate acetoacetate II: fabF GalU: galU (3E,5Z)-tetradeca- -tetradecenoyl-CoA ACP S- protein-tyrosine- diphosphate LLO_RS05360 NAD(P)H-hydrate VI (periplasmic) decarboxylase: β bifunctional UDP-N- UTP--glucose- 3,5-dienoyl-CoA 3-hydroxyacyl-CoA malonyltransferase: phosphatase: reductase: a 3-oxooctanoyl-[acp] -D-fructose 1,6- arg asp dehydratase/ a debranched 2-oxoacid:ferredoxin tRNA 2- glycerophosphodiester DNA-3- acyl-CoA LLO_RS08930 enoyl-ACP UDP-α-D- acetylglucosamine 1-phosphate pentose phosphate dehydrogenase: α,α-trehalose signal fabD saccharopine LLO_RS10145 LLO_RS07370 a 3-oxoacyl-[acp] bisphosphate NAD(P)H-hydrate acyl-CoA α-limit dextrin bifunctional oxidoreductase thiocytidine(32) phosphodiesterase: ugpQ methyladenine thioesterase: reductase galactose diphosphorylase/ pathway (oxidative branch) I peptidase ACP S- dehydrogenase: acetoacetate 3-oxoacyl-ACP uridylyltransferase epimerase: thioesterase: LLO_RS09265 4-hydroxy-2- subunit beta: glycerophosphoryl diester glycosylase: LLO_RS01100 tyrosine LLO_RS07375 FabI: fabI biosynthesis glucosamine-1- synthetase I: lepB LLO_RS11845 decarboxylase: GalU: galU D-glucopyranose LLO_RS01820 LLO_RS00160 3-hydroxyacyl-CoA glucoamylase: oxoglutarate alpha,alpha-trehalase: LLO_RS09930 phosphodiesterase: LLO_RS04570 malonyltransferase: phosphatase: reductase phosphate N- TtcA: ttcA [+ 3 isozymes] LLO_RS03210 CDP UDP-α-D-glucose 6-phosphate [+ 2 isozymes] dehydrogenase: LLO_RS14195 aldolase/2- LLO_RS17380 LLO_RS17065 a malonyl- fabD LLO_RS03790 a hexanoyl-[acp] FabG: fabG acetyltransferase UDP-α-D-glucose 3-oxoacyl- glucose-6- NADPH α dehydro-3-deoxy- a [protein]- acetone F6P UDP-glucose (3E,5Z)- LLO_RS11835 -D- a reduced 32 an [L-cysteine a DNA containing [PedD acyl- a (3R)-3- ACP GlmU: glmU phosphate + a 2-thiocytosine an alkylated allysine L-tyrosine beta- 4-epimerase glucopyranose phosphogluconate an acyl-CoA CO H an apurinic/ a leader sequence a peptide carrier protein] propanoate glu beta- hydroxyoctanoyl-[acp] reductase dehydrogenase: tetradecadienoate 3-oxo-(5Z)- D-glucopyranose α-D-glucopyranose β-D-glucopyranose 2 ferredoxin [iron- in tRNA desulfurase]- nucleobase ketoacyl- glucose-6- GalE: galE UDP-N-acetyl- 1-phosphate aldolase: glycerol ketoacyl- zwf tetradecenoyl-CoA sulfur] cluster L-cysteine sn-glycerol 3-phosphate apyrimidinic site 3-hydroxyacyl- ACP FabG: fabG phosphate α-D-glucosamine 6-phospho LLO_RS09965 ACP UDP-glucose acetyl-CoA C- ACP dehydratase synthase a (3R)-3- isomerase: pgi D-glucono- phosphomannomutase/ glucokinase: synthase a 2,3,4-saturated 4-epimerase acyltransferase: bifunctional FabZ: fabZ II: fabF hydroxyacyl-[acyl- D-glucopyranose 1,5-lactone phosphoglucomutase: glk II: fabF GalE: galE 4-hydroxy-2- UDP-N-acetyl-α-D-muramoyl-L- trans,octacis N-acetyl-muramoyl-(L- fatty acyl-[acp] α LLO_RS05515 LLO_RS15470 dihomo γ- D-firefly a supercoiled UDP 3-hydroxyacyl-carrier protein] 6-phosphate UDP- -D-galactose 6-phosphogluconolactonase: oxoglutarate γ 3-methylbutanoate -decaprenyl γ a holo [PedN acyl- H O H O RNA a 3-oxooctanoyl- a (2E)-oct-2-enoyl-[acp] acetyl-CoA C- alanyl- -D-glutamyl-meso-2,6- PRPP alanyl- -D-glutamyl-L- a PII protein linolenoyl-CoA 2 luciferyl-CoA 2 duplex DNA ACP pgl UTP carrier protein] ribonucleotide- [acp] acyltransferase: aldolase/2- diaminopimeloyl-D-alanyl-D-alanine phosphate lysyl-D-alanyl-D-alanine) ACP S- conjugative dehydratase D-gluconate diphosphate enoyl-[acyl- LLO_RS11830 dehydro-3-deoxy- malonyltransferase: transfer 3-oxoacyl- FabZ: fabZ 6-phosphate acetate- acyl-CoA acyl-CoA reductase: carrier-protein] D-glucopyranose phosphogluconate [protein-PII] fabD ribonuclease relaxase/ ACP peptidoglycan biosynthesis I (meso-diaminopimelate containing) Cell Structure Biosynthesis (3Z)-dodec- penicillin-binding -CoA decaprenyl-phosphate penicillin-binding thioesterase: thioesterase: LLO_RS07370 reductase lipid IV biosynthesis (P. putida) Kdo transfer to peptidoglycan maturation (meso-diaminopimelate containing) 6-phosphate aldolase: phosphoribosyltransferase: uridylyltransferase: PH: rph helicase A lipid IV biosynthesis (E. coli) 3-enoyl-CoA protein 2: mrdA ligase: acs protein 2: mrdA ACP S- LLO_RS07375 reductase A LLO_RS14205 LLO_RS00160 LLO_RS00160 FabL: fabL lipid IV I (E. coli) ∆ ∆ LLO_RS04795 glnD TraI: traI FabG: fabG UDP-N-acetyl-α-D-glucosamine A 3, 2-enoyl- [+ 2 isozymes] [+ 2 isozymes] malonyltransferase: dUDP [+ 2 isozymes] a (3R)-3- a (3R)-3- lipid II (meso Macromolecule Modification [+ 2 isozymes] [+ 2 isozymes] a (3R)-3- enoyl-ACP D-ribulose CoA isomerase: a malonyl[PedNfabD [+ 4 isozymes] a trans-2- UDP-N-acetylglucosamine hydroxydecanoyl- UDP-N-acetyl- CMP-Kdo lipid IV (E. coli) diaminopimelate containing) D-glyceraldehyde 3-methylbutanoyl- a nucleoside a single a 2,3,4-saturated hydroxytetradecanoyl- UDP-N-acetyl- A 5-phosphate RNA hydroxyoctanoyl- reductase enoyl-[acyl- LLO_RS09265 pyruvate UDP-N-acetylmuramoyl-L- diphosphate trans,octacis- N-acetyl-muramoyl-(L- acyl-carrier stranded DNA an octanoyl-[acp] fatty acyl-[acp] 1-carboxyvinyltransferase: [acp] α-D-glucosamine [acp] α-D-glucosamine peptidoglycan tRNA-uridine 2-thiolation 3-phosphate AMP CoA a uridylylated di-homo-γ- diphosphate [acp] FabI: fabI carrier protein] (2E)-dodec- D-ala alanyl-γ-D-glutamyl-meso-2,6- decaprenylphospho- alanyl-γ-D-glutamyl- D-ala protein] D-firefly luciferin murA glycosyltransferase: PII protein 3-hydroxyacyl- [+ 2 isozymes] 3-deoxy-D-manno- and selenation (bacteria) type I diaminopimeloyl-D-alanine β-D-ribofuranose L-lysyl-D-alanine) linolenate acyl-ACP--UDP-N- acyl-ACP--UDP-N- 2-enoyl-CoA ACP UDP-N-acetyl-α-D-glucosamine-enolpyruvate octulosonic acid rodA glyceraldehyde- 5-phosphate acetylglucosamine O- acetylglucosamine O- enoyl-CoA dehydratase transferase: a nascent peptidoglycan cys 3-phosphate enoyl-ACP UDP-N-acetylmuramate acyltransferase: lpxA acyltransferase: lpxA hydratase: FabZ: fabZ LLO_RS02885 with (L-alanyl-γ-D-glutamyl- dehydrogenase: dehydrogenase: murB LLO_RS04580 (1S,2R)-1- an N-terminal- gondoate biosynthesis reductase meso-2,6-diaminopimeloyl-D- trehalose degradation II (cytosolic) a long-chain + ala UDP-3-O-[(3R)-3- cysteine gap a ferrocytochrome palmitoyl-CoA an acyl-[acyl- carbamoyl a holo [BryP acyl- H O malonyl-CoA H a folate chorismate a (2E)-oct- UDP-3-O-[(3R)-3- (S)-3- ser C-(indol-3- L-ornithine L-methionyl-L- 2 ser (anaerobic) FabI: fabI glu UDP-N-acetyl-α-D-muramate α-Kdo-(2->6)- alanyl-D-alanine) pentapeptide desulfurase: b carrier protein] phosphate carrier protein] fatty acyl-CoA 2-enoyl-[acp] hydroxydecanoyl]- hydroxymyristoyl]-N- 5 yl)glycerol cysteinyl-[protein] dihydrofolate chorismate enoyl-ACP lipid IV (E. coli) hydroxydodecanoyl-CoA α α ACP S- α A LLO_RS15510 13-DPG , -trehalose L-serine N-acetyl- -D- acetyl-α-D-glucosamine 3-phosphate malonyltransferase: reductase: mutase: enoyl-ACP a malonyl-[acp] an oleoyl-[acp] reductase: glutamate racemase: UDP-N-acetylmuramate- KDO transferase: penicillin-binding penicillin-binding 3-hydroxyacyl- acyl-CoA type III ammonia-lyase: glucosamine UDP-3-O-acyl-N- IscS subfamily acyl-CoA phosphate ornithine type I methionyl LLO_RS02410 LLO_RS06820 reductase: LLO_RS05360 LLO_RS02965 -L-alanine ligase: LLO_RS02885 protein 2: mrdA protein 2: mrdA CoA phosphoglycerate fabD thioesterase: polyketide UDP-3-O-acyl-N- acetylglucosamine cysteine alpha,alpha-trehalase: tryptophan dihydrofolate LLO_RS10520 LLO_RS05360 LLO_RS13975 [+ 2 isozymes] [+ 2 isozymes] a mature peptidoglycan with dehydrogenase/ kinase: desaturase: acyltransferase carbamoyltransferase: aminopeptidase: ACP S- chorismate acetylglucosamine deacetylase: α-Kdo-(2->4)-α-Kdo- desulfurase: LLO_RS17380 synthase: trpB LLO_RS01100 synthase: pyruvate beta-ketoacyl- (L-alanyl-γ-D-glutamyl-meso- LLO_RS16475 LLO_RS10780 PlsX: plsX argF map malonyltransferase: reductase: mutase: enoyl-ACP D-glt deacetylase: LLO_RS13945 (2->6)-lipid IV (E. coli) LLO_RS11720 enoyl-CoA LLO_RS06000 [+ 3 isozymes] LLO_RS08215 A a nascent peptidoglycan a nascent peptidoglycan LLO_RS18665 LLO_RS06825 reductase ACP synthase UDP-N-acetyl-α-D-muramoyl-L-alanine 2,6-diaminopimeloyl-D-alanyl- an [L-cysteine hydratase 3-phospho- a malonyl- fabD LLO_RS13945 UDP-3-O-(3- with (L-alanyl-γ-D-glutamyl- with D,D cross-links (meso- α-D-glucopyranose β-D-glucopyranose FabI: fabI II: fabF biotin-carboxyl carrier UDP-3-O-(3- D-alanine) pentapeptide desulfurase]-S- family protein: D-glycerate D-glyceraldehyde an N-terminal L- [BryP acyl- a 7,8-dihydrofolate prephenate hydroxymyristoyl) meso-2,6-diaminopimeloyl- diaminopimelate containing) palmitoleoyl-CoA a ferricytochrome protein assembly UDP-N-acetylmuramoyl- hydroxydecanoyl) α sulfanyl-L-cysteine LLO_RS11835 acyl-carrier protein an acyl phosphate 3-phosphate trp L-citrulline met cysteinyl-[protein] carrier protein] a long-chain octoketide - -D-glucosamine D-alanine) tetrapeptide b L-alanine--D-glutamate 5 fatty acid an octanoyl-[acp] an (11Z)-3-oxo- a [biotin carboxyl- -α-D-glucosamine UDP-3-O-(3- ligase: LLO_RS13985 UDP-3-O-(3- hydroxymyristoyl) 3-oxododecanoyl-CoA icos-11-enoyl-[acp] carrier protein]-L-lysine L,D-transpeptidase: LD-carboxypeptidase: L,D-transpeptidase: beta- hydroxymyristoyl) glucosamine N- a mature peptidoglycan 2-phospho- biotin-- α LLO_RS07470 LLO_RS02355 LLO_RS07470 a [TusA sulfur- acetyl-CoA C- D-glucopyranose UDP-N-acetyl- decaprenyl-diphospho-N- 34 a thiocarboxylated a peptide with a 3,5,7,9,11,13,15- D-ribulose 3-oxoacyl-ACP meso-diaminopimelate UDP-N-acetyl- -D-muramoyl- D-glycerate a uridine + a double ketoacyl- glucosamine N- acyltransferase: with D,D cross-links (meso- α-D-glucosamine 2-methylbutanoate FMN NAD(P)H H a holo [BryU acyl- a [peptide] with a reductase [acetyl-CoA- L-alanyl-D-glutamate [+ 6 isozymes] LD-carboxypeptidase: [+ 6 isozymes] a mature peptidoglycan carrier protein]-S- acyltransferase: acetylmuramoyl-pentapeptide in tRNA [SAMP] C- an N-terminal hepta-oxo- stranded DNA IMP 5-phosphate ACP acyltransferase: lpxD diaminopimelate containing) phosphopyruvate carrier protein] C-terminal L-lysine ribulose- FabG: fabG carboxylase] LLO_RS03860 with (L-alanyl-γ-D-glutamyl- sulfanyl-L-cysteine LLO_RS11830 glucokinase: glk terminal glycine Xaa-L-proline ACP S- hexadecanoyl-[PKS-acp]aldo/keto DNA synthase lpxD a nascent peptidoglycan hydratase: eno 5'/3'-nucleotidase phosphate 3- ligase: UDP-N-acetylmuramoyl- D-ala UDP-3-O-(3- a nascent peptidoglycan meso-2,6-diaminopimeloyl- acetyl-CoA C- undecaprenyldiphospho- malonyltransferase: reductase: topoisomerase II: fabF a (3R,11Z)-3-hydroxy- γ acetate- NAD(P)H-flavin SurE: surE LLO_RS10545 L-alanyl-D-glutamate-- UDP-3-O-(3- hydroxymyristoyl) with L,D cross links (meso- a nascent peptidoglycan with with (L-alanyl- -D-glutamyl- D-alanine) tetrapeptide phosphoenol muramoylpentapeptide beta-N- tRNA 2- Xaa-Pro fabD LLO_RS08070 (ATP- epimerase: icos-11-enoyl-[acp] acyltransferase: D-glucopyranose 6-phosphate -CoA reductase: peptidase S10: a 3-oxodecanoyl- a [biotin carboxyl- 2, 6-diaminopimelate hydroxymyristoyl) glucosamine N- diaminopimelate containing) (L-alanyl-γ-D-glutamyl-meso- meso-2,6-diaminopimeloyl- pyruvate acetylglucosaminyltransferase: thiouridine(34) aminopeptidase: hydrolyzing) 5' nucleotidase: rpe D-alanine--D-alanine a [TusD sulfur- LLO_RS05515 ligase: acs LLO_RS00465 ACP S- aldo/keto LLO_RS08020 D-xylulose [acp] 3-hydroxyacyl- carrier protein]-N ligase: LLO_RS04410 glucosamine N- acyltransferase: 2,6-diaminopimelate) tripeptide glycine) tetrapeptide LLO_RS10445 synthase subunit B: gyrB LLO_RS16780 ligase: LLO_RS13965 carrier protein]-S- pyruvate pepP malonyltransferase: reductase: 5-phosphate ACP dehydratase 6 -biotinyl-L-lysine acyltransferase: lpxD decanoyl-CoA MnmA: mnmA inosine 3-oxoacyl- sulfanyl-L-cysteine kinase: pyk fabD LLO_RS08500 [+ 3 isozymes] FabZ: fabZ UDP-N-acetyl-α-D-muramoyl-L-alanyl- lpxD UDP-2-N,3-O-bis[(3R)- (2S)-2- a malonyl- 9-hydroxy-3,5,7,11,13,15- a negatively D-alanyl-D-alanine a mature peptidoglycan + ACP acyl-CoA decaprenyl-pyrophosphoryl- UDP methylbutanoyl- diphosphate a peptide with FMNH NAD(P) [BryU acyl- hexaoxohexadecanoyl- γ-D-glutamyl-meso-2,6-diaminopimelate UDP-2-N-[(3R)-3- 3-hydroxytetradecanoyl]- 34 a proteinogenic 2 supercoiled DNA reductase a (2E,11Z)-icosa- with L,D cross-links (meso- a mature peptidoglycan with a mature peptidoglycan pyruvate (N-acetylglucosamine)-N- a [SAMP] C- a 2-thiouridine AMP lys a peptide α dehydrogenase: CoA an N-terminal carrier protein] [PKS-acp] hydroxydodecanoyl]- -D-glucosamine γ with (L-alanyl-γ-D-glutamyl- terminal glycine in tRNA amino acid FabG: fabG 2,11-dienoyl-[acp] a [biotin carboxyl- UDP-N-acetylmuramoyl- diaminopimelate containing) (L-alanyl- -D-glutamyl-meso- a [TusE sulfur LLO_RS04575 acetylmuramyl-(pentapeptide) L-proline a (3R)-3- carrier-protein dimer]- 3-O-[(3R)-3- UDP-2,3- 2,6-diaminopimelate) tripeptide meso-2,6-diaminopimeloyl- Degradation/Utilization/Assimilation - Other enoyl-ACP tripeptide--D-alanyl- hydroxydecanoyl]- 34 carrier protein]-S [+ 5 isozymes] hydroxydecanoyl- N 6 -biotinyl-L-lysine diacylglucosamine glycine) tetrapeptide a uridine in tRNA reductase D- alanine ligase: α-D-glucosamine -sulfanylcysteine core oligosaccharide- a [ribosomal (3R)-3- [acp] diphosphatase: octane oxidation a 1-palmitoyl-2-acyl- (5Z,8Z,11Z,14Z,17Z) + acetyl-CoA LLO_RS13995 (2E)-dec-2-enoyl-CoA acrylonitrile isobutanoate NADP FMNH a [protein] Ser/Thr cadaverine putrescine Ap4A 3-hydroxyacyl- FabI: fabI UDP-2,3- LLO_RS07800 lipid A (E. coli K-12 phosphatidylethanolamine DL-allothreonine -icosapentaenoyl-CoA 2 protein L3]- hydroxypentanoyl- ala acetyl-CoA carboxylase tRNA 2- 2 degradation I core type) (no GlcNAc) serine/threonine L-glutamine CoA ACP enoyl-ACP α diacylglucosamine trans-∆ - 50S ribosomal acetoacetyl- symmetrical carboxylase biotin UDP-N-acetyl- -D-muramoyl-L- lipid X thiouridine(34) NADH protein kinase: alanine dehydratase reductase: γ diphosphatase: decenoyl-CoA protein L3 CoA bis(5'-nucleosyl)- carboxyltransferase carboxylase alanyl- -D-glutamyl-meso-2,6- di-trans,octa-cis-undecaprenyl phosphate synthase acrylonitrile acyl-CoA NAD(P)H-flavin LLO_RS10110 homospermidine transaminase: FabZ: fabZ LLO_RS05360 LLO_RS07800 hydratase: lipid IV(A) acetate--CoA serine N(5)-glutamine tetraphosphatase: subunit beta: subunit: diaminopimeloyl-D-alanyl-D-alanine lipid-A- MnmA: mnmA thioesterase: reductase: synthase: reductase: alaC palmitoyltransferase ligase: acs hydroxymethyltransferase: serine/threonine methyltransferase: LLO_RS00670 a (2E)-dec- LLO_RS11890 LLO_RS05495 disaccharide LLO_RS04580 LLO_RS00160 LLO_RS00465 LLO_RS16880 phbB a gondoyl-[acp] lipid X (P. putida) PagP: pagP LLO_RS04245 protein kinase: prmB pyruvate 2-enoyl-[acp] phospho-N-acetylmuramoyl- synthase: lpxB 34 (S)-3- a [ribosomal [+ 2 isozymes] acetyl-CoA acetyl-CoA a 2-thiouridine acrylamide [+ 2 isozymes] LLO_RS00175 3-oxopentanoyl- ADP pentapeptide- transferase: lipid-A- lipid A disaccharide in tRNA hydroxydecanoyl-CoA a reduced protein L3]- enoyl-ACP carboxylase carboxylase octane isobutanoyl-CoA + a [protein] (L-serine/L- N-(4-aminobutyl) 5 CoA LLO_RS13990 disaccharide (E. coli) rubredoxin a 2-acyl-1-lyso- a hepta-acylated core diphosphate FMN NADPH H N -methyl- reductase: subunit alpha: biotin tRNA uridine-5- (S)-3- amidase: AMP acetaldehyde threonine) phosphate -cadaverine synthase: lpxB phosphatidylethanolamine oligosaccharide lipid gly (5Z,8Z,11Z,14Z,17Z) L-glutamine LLO_RS05360 LLO_RS13190 carboxylase tetraacyldisaccharide 4'- carboxymethylaminomethyl(34) hydroxydecanoyl- LLO_RS08515 coenzyme A undecaprenyldiphospho-N-acetylmuramoyl- lipid A A (E. coli K-12 type) -icosapentaenoate subunit: accC kinase: LLO_RS05550 synthesis GTPase MnmE: mnmE CoA alkane 1- amidase: enoyl-ACP L-alanyl-γ-D-glutamyl-meso-2,6- disaccharide a [carboxyl-carrier dehydrogenase: monooxygenase: LLO_RS08535 reductase diaminopimeloyl-D-alanyl-D-alanine (P. putida) lipid IV (E. coli) tRNA uridine-5- protein dimer]-N 6 - A LLO_RS11835 LLO_RS12100 core oligosaccharide- a [protein]-L- D-ribose 5- FabI: fabI undecaprenyldiphospho- carboxymethylaminomethyl(34) a 1-palmitoyl-2-acyl- a ferrocytochrome a [protein] N-terminal- + tetraacyldisaccharide 4'- acrylate lipid A (E. coli K-12 acetoacetate stearoyl-CoA FMN NADH H aci-nitroethane a carboxylic ester N-acetylputrescine ω acetyl-CoA carboxybiotinyl-L-lysine muramoylpentapeptide beta-N- synthesis enzyme MnmG: mnmG 3-oxodecanoyl-CoA phosphatidylglycerol b formyl-L-methionine proline ( = 180) phosphate a decanoyl-[acyl- kinase: LLO_RS05550 core type) (no GlcNAc) 5 peptidyl-prolyl acetyl-CoA ribose-5- acetylglucosaminyltransferase: a 5-carboxymethylaminomethyl- octan-1-ol carrier protein] lipid IV cis-trans carboxylase phosphate A 34 acetyl-CoA C- LLO_RS10445 2-thiouridine in tRNA peptide NAD(P)H-flavin nitronate acetylpolyamine beta- (P. putida) acyltransferase: lipid IV(A) acetoacetate--CoA acyl-CoA carboxylesterase: isomerase: subunit alpha: isomerase deformylase: def reductase: monooxygenase: amidohydrolase: ketoacyl- lipid II (meso diaminopimelate containing) LLO_RS11830 palmitoyltransferase ligase: LLO_RS05485 desaturase: LLO_RS02735 LLO_RS06630 LLO_RS13190 RpiA: rpiA peptide LLO_RS00465 LLO_RS04080 LLO_RS14015 D-ribulose ACP fatty acid biosynthesis PagP: pagP LLO_RS10780 [+ 3 isozymes] [+ 5 isozymes] acetyl-CoA C- deformylase: def a [protein]-L- 5-phosphate synthase initiation (type II) a 5-aminomethyl-2- 1-octanal malonyl-CoA acyltransferase: proline (ω = 0) II: fabF thiouridine 34 in tRNA LLO_RS05515 a hepta-acylated core acetoacetyl-CoA diphosphate FMNH NAD + acetaldehyde nitrite an alcohol a carboxylate acetate putrescine 1-octanal a 2-acyl-1-lyso- AMP 2 a 3- acetyl-CoA oligosaccharide lipid a ferricytochrome oleoyl-CoA an N-terminal L- 5-methylaminomethyl- dehydrogenase: phosphatidylglycerol formate oxododecanoyl- acetyl-CoA carboxylase [2Fe-2S] iron-sulfur Cofactor, Carrier, and Vitamin Biosynthesis octanoyl-CoA b methionyl-[protein] ubiquinol-8 biosynthesis ubiquinol-8 biosynthesis superpathway of heme b superpathway of coenzyme A biosynthesis I (bacteria) 2-thiouridine-forming A (E. coli K-12 type) 5 [acp] carboxyltransferase cluster biosynthesis LLO_RS12620 (early decarboxylation) (late decarboxylation) superpathway of tetrahydrofolate biosynthesis biosynthesis from glutamate methyltransferase: subunit beta: acyl-CoA 3-oxoacyl- 3-methyl-2- a 5,10- mnmC octanoate ACP LLO_RS11890 L-cysteine desulfurase all-trans- dehydrogenase: core oligosaccharide- a 1-palmitoyl-2-acyl- an N 3 -methyladenine (-)-methyl succinate a (2E,4Z)-2,4- chorismate oxobutanoate methylenetetrahydrofolate a 5-methylaminomethyl- H + hydrogencarbonate fumarate methylsalicylate a D-hexose reductase octaprenyl glu LLO_RS04575 lipid A (E. coli K-12 a charged tRNA a peptidyl-[tRNA] in DNA asp acetyl-CoA 4-hydroxybenzoate GTP 34 phosphatidylserine jasmonate GTP semialdehyde dienoyl-CoA diphosphate glutamate- 2-thiouridine in tRNA FabG: fabG carboxylase subunit cysteine [+ 5 isozymes] core type) (no GlcNAc) NAD-dependent NADPH- -tRNA 3-methyl-2-oxobutanoate glucokinase: a (3R)-3- alpha: LLO_RS13190 desulfurase: adenylate/guanylate succinate- dependent 2,4- 4-hydroxybenzoate GTP ligase: gltX hydroxymethyltransferase: carbonic DNA-3- glk hydroxydodecanoyl- LLO_RS15510 an L-glutamyl- (2E)-oct-2-enoyl-CoA lipid IV(A) L-aspartate carboxylesterase: carboxylesterase: cyclase domain- semialdehyde dienoyl-CoA malonyl-CoA octaprenyltransferase: all-trans-octaprenyl cyclohydrolase panB octanoyl-CoA transpeptidase: anhydrase: methyladenine [acp] 4-hydroxybenzoate [tRNA Glu ] NAD salvage pathway III palmitoyltransferase oxidase: LLO_RS02735 LLO_RS02735 containing protein: dehydrogenase: reductase: IscS subfamily diphosphate I FolE: folE a 5-methylaminomethyl- enoyl-CoA LLO_RS09040 glycosylase I: D-hexose 6- 3-hydroxyacyl- ACP S- LLO_RS09125 asp (to nicotinamide riboside) LLO_RS12935 nadB LLO_RS09210 LLO_RS14420 cysteine flavin biosynthesis I (bacteria and plants) 7,8- 2-(S-geranyl) hydratase: PagP: pagP LLO_RS08525 phosphate malonyltransferase: fabD glutamyl-tRNA [+ 3 isozymes] LLO_RS12570 a (2E)-2- ACP desulfurase: dihydroneopterin 2-dehydropantoate thiouridine 34 in tRNA [+ 5 isozymes] succinate 4-hydroxy-3- 4-hydroxybenzoate reductase: aspartate 1- NADP + LLO_RS04580 enoyl-CoA dehydratase ACP S- LLO_RS11720 3'-triphosphate a hepta-acylated core (-)-jasmonate MeOH salicylate MeOH cyclic-GMP octaprenylbenzoate octaprenyltransferase: LLO_RS02905 decarboxylase: (S)-3- a 2-acyl-1-lyso- a peptidyl- an uncharged 2-iminosuccinate succinate FabZ: fabZ malonyltransferase: fabD GTP oligosaccharide lipid an apurinic site an S-sulfanyl-[L- LLO_RS09125 LLO_RS00655 hydroxyoctanoyl-CoA phosphatidylserine aminoacyl-[tRNA] tRNA CO H O 3-methyladenine 4-hydroxy-3- (S)-4-amino-5- 2 2 within DNA a (2E)-dodec- a 5-methylaminomethyl- A (E. coli K-12 type) a malonyl-[acp] cysteine desulfurase] polyprenylbenzoate oxopentanoate + 3-hydroxyacyl- 2-enoyl-[acp] β-alanine NAD decarboxylase: ubiD 4-hydroxy-3- bifunctional 7,8- (R)-pantoate 2-(Se-phospho) CoA glutamate-1- 34 α 34 enoyl-ACP ketoacyl-ACP synthase octaprenylbenzoate 3,4-dihydroxy- dihydroneopterin NAD(+) selenouridine in tRNA dehydrogenase/ a [glycine-cleavage -D-Kdo-(2->4) a 1-palmitoyl-2- a [protein]-S- a uridine all-trans- acibenzolar- all-trans- a cis-delta19- a (2E,4E)-2,4- semialdehyde (2E,6E)-farnesyl acetamide reductase: 2-octaprenylphenol 4-hydroxy-3- 2-butanone-4- 3'-phosphate diphosphatase: a sulfurated [sulfur carrier] SAM complex H protein] -α-D-Kdo-(2->6) acyl-sn-glycero-3- sulfanyl-L-cysteine in tRNA protoheme 37-methoxy-38- III: LLO_RS07585 chorismate 2,1- pantoate-- enoyl-CoA diphosphate retinyl palmitate S-methyl retinyl palmitate ATP dienoyl-CoA an S-sulfanyl-[cysteine 6 -lipid A (E. coli) phosphocholine NADPH- LLO_RS05360 ketoacyl-ACP synthase octaprenylbenzoate phosphate synthase/ aminomutase: nudC hydratase N -octanoyl-L-lysine methyl-C57:1-[acp]cyclopropane amidase: desulfurase]-[disordered- 2-octaprenylphenol beta-alanine enoyl-ACP III: LLO_RS13220 5-hydroxylase: ubiH GTP cyclohydrolase aminodeoxychorismate/ a 5-methylaminomethyl- family protein: adenylate/guanylate fatty acyl dependent 2,4- LLO_RS08515 6-hydroxylase: ubiH hemL ligase: panC NMN tRNA 2- reductase form scaffold II: LLO_RS05330 anthranilate 2-selenouridine 34 LLO_RS11835 lipid IV(A) protoheme IX carboxylesterase: carboxylesterase: carboxylesterase: cyclase domain- dienoyl-CoA 3,4-dihydroxy-5-all- D-erythro-7,8- lipoyl thiouridine(34) phospholipid [+ 2 isozymes] FabI: fabI an acetoacetyl-[acp] protein] complex 3-(all-trans synthase component 5-aminolevulinate in tRNA palmitoyltransferase farnesyltransferase: LLO_RS02735 LLO_RS02735 LLO_RS02735 containing protein: reductase: [cysteine desulfurase]-S- trans-octaprenylbenzoate GTP cyclohydrolase dihydroneopterin 5' nucleotidase: synthase: lipA synthase synthase: cfa -octaprenyl) II: LLO_RS10335 (R)-pantothenate 3-oxooctanoyl-CoA PagP: pagP LLO_RS14250 LLO_RS08525 a cis-methoxy- LLO_RS14420 acetate sulfanylcysteine:[acceptor octaprenyldihydroxybenzoate II: LLO_RS13250 LLO_RS16780 MnmA: mnmA a (2E)-2- a dodecanoyl-[acp] benzene-1,2-diol dihydroneopterin aminodeoxychorismate porphobilinogen [+ 5 isozymes] C59-meroacyl-[acp] protein]-cysteine methyltransferase: ubiG 2,5-diamino-6-(5-phospho-D- 1-(β-D acetyl-CoA C- enoyl-CoA bifunctional 2- aldolase: folB synthase: hemB type III a [glycine-cleavage all-trans-retinol palmitate MeOH palmitate a retinol cyclic-AMP sulfurtransferase: ribosylamino)pyrimidin-4(3H)-one synthase hepta-acylated Kdo acibenzolar pantothenate ribofuranosyl) acyltransferase: 5'-deoxyadenosine 6 an unsulfurated a 2-acyl-sn-glycero- 2 34 ferroheme o polyprenyl-6- 3-methoxy-4-hydroxy-5-all- 6-(hydroxymethyl) component I: pabB protein S-nitrosylation met complex H protein] N lipid A (E. coli) a [protein]- a 2-thiouridine LLO_RS11720 bifunctional porphobilinogen kinase: nicotinamide LLO_RS11830 3-phosphocholine beta- a [cysteine desulfurase]- hydroxyphenol trans-octaprenylbenzoate and denitrosylation -[(R)-lipoyl]-L-lysine [sulfur carrier] L-cysteine in tRNA diaminohydroxyphosphoribosylaminopyrimidine -7,8-dihydropterin 4-amino-4- ketoacyl- methylase/3- LLO_RS04385 acetyl-CoA C- S-sulfanyl-[disordered- 2-amino-4-hydroxy-6- deoxychorismate a [protein]- demethylubiquinol 3- deaminase/5-amino-6-(5-phosphoribosylamino) hydroxymethylbilane (R)-4'- acyltransferase: ACP form scaffold hydroxymethyldihydropteridine laurate uracil reductase RibD: ribD synthase: hemC L-cysteine LLO_RS05515 a [pyruvate dehydrogenase E2 lysine within 1,6-anhydro-N- synthase protein] complex O-methyltransferase phosphopantothenate a protein with chitin an L-aspartyl- a ribonucleoside 2+ diphosphokinase: folK 6 an octanoyl-[acp] glutathione coenzyme A an all-trans-retinyl ester a protein Fe cysteine UbiG: ubiG 2-methoxy-6-(all-trans 5-amino-6-(5-phospho- a sulfurated [sulfur carrier] SAM protein] N -octanoyl-L-lysine gcv protein H Asn diphosphate acetyl-β-muramate II: fabF (7,8-dihydropterin- bifunctional a disulfide bond [tRNA ] desulfurase: 2-methoxy- -octaprenyl)phenol D-ribosylamino)uracil preuroporphyrinogen hexanoyl-CoA Asp-tRNA(Asn) ribonucleotide- anhydro-N- metalloprotease 6-yl)methyl phosphopantothenoylcysteine acetylmuramic bacterioferritin: LLO_RS15510 6-(all-trans- 2-octaprenyl-6- bifunctional 4-aminobenzoate a [protein] 3- beta-N- /Glu-tRNA(Gln) diphosphate PmbA: pmbA a 3-oxotetradecanoyl- D-ribulose 5-phosphate diphosphate uroporphyrinogen- decarboxylase/ acyl-CoA lipoyl(octanoyl) CoA pyrophosphatase: carboxylesterase: acid kinase: LLO_RS05155 octaprenyl)phenol methoxyphenyl diaminohydroxyphosphoribosylaminopyrimidine nitrosothio- acetylhexosaminidase: amidotransferase: reductase: metalloprotease [acp] lauroyl-CoA IscS subfamily III synthase: phosphopantothenate-- dehydrogenase: transferase glutaredoxin 2-octaprenyl-6- hydroxylase: ubiH lipoyl synthase: lipA LLO_RS07785 LLO_RS02735 nagZ gatC gatA gatB LLO_RS07370 LLO_RS07635 cysteine deaminase/5-amino-6-(5-phosphoribosylamino) dihydropteroate LLO_RS01675 cysteine ligase CoaBC: coaBC L-alanine N-acetyl-D- TldD: tldD 3+ methoxyphenyl bifunctional pyridoxal 5'-phosphate biosynthesis I LLO_RS04575 LipB: lipB 3: grxC an L-asparaginyl- LLO_RS07375 Fe 3-oxoacyl- desulfurase: 2-methoxy-6-all trans- uracil reductase RibD: ribD synthase: folP (R)-4'- a 2'- muramate 6- a peptide 3,4-dihydroxy- [+ 5 isozymes] [tRNA Asn ] ACP hydroxylase: ubiH uroporphyrinogen-III N-acetyl-D- deoxyribonucleoside phosphate LLO_RS11720 2-methoxy-6-all octaprenyl-1,4-benzoquinol 2-butanone-4- 5-amino-6-(5-phospho- phosphopantothenoyl- D-erythrose a [glycine-cleavage reductase an S-sulfanyl-[cysteine a [pyruvate dehydrogenase a protein with 3',5'-ADP 4'-phosphopantetheine all-trans-retinol a fatty acid chitin bifunctional phosphate synthase/ D-ribitylamino)uracil 7,8- L-cysteine 4-phosphate (2E)-hexenoyl-CoA acyl-carrier protein complex H protein] glucosamine 5'-diphosphate trans-octaprenyl- uroporphyrinogen 5'-deoxyadenosine 6 GSSG FabG: fabG desulfurase]-S- met E2 protein] N -lipoyl-L-lysine an unsulfurated [sulfur carrier] 6 reduced L- demethylmenaquinone GTP cyclohydrolase dihydropteroate bifunctional a [protein]- N -octanoyl-L-lysine a (3R)-3- sulfanyl-[disordered- 1,4-benzoquinol decarboxylase: S-nitrosoglutathione enoyl-CoA cysteine residues methyltransferase/2- II: LLO_RS05330 bifunctional phosphopantothenoylcysteine L-cysteine hydroxytetradecanoyl- phosphatidylglycerol form scaffold bifunctional LLO_RS12725 hydratase: methoxy-6-polyprenyl- tetrahydrofolate decarboxylase/ [acp] biosynthesis II (non-plastidic) protein] complex demethylmenaquinone 1-deoxy-L-glycero- 4-phospho- S-(hydroxymethyl) LLO_RS04580 [cysteine desulfurase]-S- 1,4-benzoquinol ARP synthase/ coproporphyrinogen III phosphopantothenate-- glutathione 3-aci- RNase III mRNA guanosine 2251 a [protein]-α- a [phospholipid]- a cis-delta21-39- phosphoenol hydroxymyristoyl- methyltransferase/2- tetrulose 4-phosphate NAD D-erythronate a 5-L-glutamyl- a ribonucleoside a single canavaninosuccinate [DNA] sulfanylcysteine:[acceptor cysteine ligase CoaBC: coaBC (S)-3- an amino acid processing in 23S rRNA palmitoleate oxo-40-methyl- ACP dehydratase: DHAP methoxy-6-polyprenyl- methylase UbiE: ubiE phosphorylation and dihydrofolate dehydrogenase/ [peptide] nitropropanoate triphosphate stranded DNA L-glutamate pyruvate oxygen-dependent 4-phosphoerythronate hydroxyhexanoyl-CoA substrate 23S rRNA protein-glutamate O- DNA cyclopropane C59:1-[acp] LLO_RS02705 glycerol-3- protein]-cysteine 1,4-benzoquinol 6-methoxy-3-methyl- transhydrogenation synthase: folC class III alcohol cyclopropane coproporphyrinogen 4'-phosphopantetheine dehydrogenase: polymerase pyruvate phosphate sulfurtransferase: 2-all-trans-octaprenyl- 6,7-dimethyl-8- dehydrogenase: 3-hydroxyhexanoyl- (guanosine(2251) methyltransferase fatty acyl fatty acyl methylase UbiE: ubiE + 7,8-dihydrofolate oxidase: hemF nitronate 3-hydroxyacyl- LLO_RS11720 ribityllumazine NAD LLO_RS04420 CoA argininosuccinate -2'-O)- CheR: III subunit phospholipid kinase: pyk dehydrogenase: a [cysteine 6-methoxy-3- 1,4-benzoquinol monoglutamate LLO_RS12580 gamma- monooxygenase: ribonuclease DNA primase: phospholipid ACP synthase: NAD(+) kinase: pantetheine- (3R)-3-hydroxy-2-oxo- dehydrogenase: lyase: argH methyltransferase LLO_RS16660 epsilon: dnaQ synthase: cfa LLO_RS02980 desulfurase]-(S- methyl-2-all- 2-octaprenyl- protoporphyrinogen IX LLO_RS04080 LLO_RS14465 a [protein]-L- a [phospholipid]-8- synthase: cfa dehydratase sn-glycerol LLO_RS06450 LLO_RS01280 phosphate S-(hydroxysulfenamide) glutamyltransferase: ggt III: rnc pyruvate trans-octaprenyl- 3-methyl-6- 4 phosphooxybutanoate LLO_RS09265 RlmB: rlmB 5 [+ 3 isozymes] a cis-keto-C60- sulfanyl) -[disordered- adenylyltransferase: glutathione 2-O- glutamate-O a 2'- (2-hexylcyclopropyl) FabZ: fabZ 3-phosphate 2 NADP + meroacyl-[acp] form scaffold 1,4-benzoquinol methoxy-1,4- 6,7-dimethyl-8- protoporphyrinogen 3-phosphoserine/ 3-hydroxyacyl-CoA methylguanosine 2251 -methyl-ester deoxyribonucleoside octanoate coaD α [unspecified RNase III a (2E)-tetradec- glycerol-3- benzoquinol ribityllumazine oxidase HemJ: hemJ phosphohydroxythreonine dehydrogenase: an -(5-L- 3-oxopropanoate nitrite ssDNA/pppN(pN) L-canavanine fumarate in 23S rRNA 5'-monophosphate protein] complex 2-octaprenyl- NAD(P) a 7,8-dihydrofolate degradation an mRNA fragment 2-enoyl-[acp] phosphate 1-O- hydroxylase: ubiH synthase: 3'-dephospho-CoA transaminase: serC LLO_RS11835 glutamyl)- a peptide processing hybrid 3-methyl-6- products] n -1 acyltransferase transhydrogenase protoporphyrin IX amino acid product mRNA enoyl-ACP methoxy-1,4- LLO_RS06455 dihydrofolate 4-phosphooxy- PlsY: plsY 3-demethylubiquinol-8 subunit beta: dephospho- hydroxylamine 3-oxohexanoyl-CoA reductase: benzoquinol reductase: L-threonine a 1-acyl-sn a [cysteine desulfurase]- LLO_RS12545 ferrochelatase: CoA kinase: D-glyceraldehyde hydroxylase: LLO_RS02410 4-hydroxythreonine- N-acetyl-β-D-glucosamine- LLO_RS05360 bifunctional 2- 6,7-dimethyl-8-(1-D-ribityl)lumazine LLO_RS08865 pyruvate acetyl-CoA C- UDP-N-acetyl-α-D-glucosamine undecaprenyl-diphospho-N an (R)-2- a [release factor]- a cytidine a [lipoyl-carrier a supercoiled -glycerol 3- [scaffold protein- hemH 3-phosphate a lipid II a glycogen 6 ubiH NADPH dihydrofolate 4-phosphate acetyltransferase: -acetylmuramoyl-L-alanyl-γ- 1,6-anhydro-N- 32 protein]-N -[(R) a protein a protein enoyl-ACP phosphate (2Fe-2S)] complex polyprenyl-6- halocarboxylate L-glutamine in tRNA duplex DNA riboflavin reductase: coenzyme A dehydrogenase LLO_RS09270 D-glutamyl-L-lysyl- D-alanine acetyl-β-D-muramate peptide chain tRNA (cytosine(32) -dihydrolipoyl]- reductase 1-acyl-sn-glycerol- 3-demethylubiquinol-8 hydroxyphenol protoheme ATP- DNA synthase: ribE LLO_RS18665 PdxA: pdxA ammonium release factor /uridine(32)-2'-O)- L-lysine FabI: fabI 3-phosphate methylase/3- [+ 2 isozymes] undecaprenyldiphospho- penicillin-binding HAD family dihydrolipoyl endopeptidase dependent zinc helicase 3-amino-1- glucoamylase: N(5)-glutamine methyltransferase acyltransferase: bifunctional 2- demethylubiquinol 3- muramoylpentapeptide beta-N- protein 2: mrdA beta-N- hydrolase: dehydrogenase: IV: LLO_RS13445 metalloprotease II: uvrD a [co-chaperone]- riboflavin a tetrahydrofolate hydroxyacetone 1-deoxy-D-xylulose butanoyl-CoA LLO_RS14195 methyltransferase: TrmJ: trmJ a myristoyl-[acp] polyprenyl-6- O-methyltransferase acetylglucosaminyltransferase: acetylhexosaminidase: LLO_RS11285 a 2'-O- lpdA FtsH: ftsH a single LLO_RS02135 [scaffold protein- 1-phosphate 5-phosphate Nucleoside and Nucleotide Degradation [+ 2 isozymes] a [lipoyl-carrier a 1,2-diacyl- nagZ prmC 32 hydroxyphenol UbiG: ubiG LLO_RS10445 5 methylcytidine 6 a peptide a peptide stranded DNA (2Fe-2S)] complex bifunctional acyl-CoA a [release factor]-N protein]-N -[(R beta- sn-glycerol thiazole component of thiamine diphosphate biosynthesis in tRNA methylase/3- riboflavin kinase/ pyridoxine 5'- tRNA processing dehydrogenase: a N-acetylglucosamine--N- D-glucopyranose a glycogen -methyl-L-glutamine )-lipoyl]-L-lysine ketoacyl- 3-phosphate ubiquinol-8 purine nucleotides degradation II (aerobic) ditrans,octacis-undecaprenyldiphospho- UDP a (2R)-2- demethylubiquinol 3- FAD synthetase: ribF phosphate LLO_RS04575 pyrimidine deoxyribonucleotides D-ala acetylmuramyl-(tetrapeptide) 1,6-anhydro-N- a halide anion ACP phosphatidate N-acetyl-(N-acetylglucosaminyl)muramoyl- GlcNAc hydroxy fatty acid O-methyltransferase thiazole component of thiamine diphosphate biosynthesis II cys synthase: pdxJ a polycistronic [+ 5 isozymes] dephosphorylation pyrophosphoryl-undecaprenol acetyl-β-muramate synthase cytidylyltransferase: a [chaperone-ATP]- FMN L-alanyl-γ-D-glutamyl-L-lysyl-D-alanine UbiG: ubiG bis(guanylyl molybdopterin) tRNA precursor nucleoside triphosphate II: fabF LLO_RS13645 [co-chaperone]- crotonyl-CoA AMP cofactor sulfurylation cysteine pyrophosphohydrolase: [scaffold protein- ubiquinol-8 bifunctional cys β a 3-oxohexadecanoyl- a CDP- desulfurase: pyridoxine 5'-phosphate 10 a peptidoglycan dimer (meso a 2,3,4-saturated an N-acetyl- - α-D-glucopyranose an [RNA]-3'- a uridine 32 riboflavin kinase/ thiamine diphosphate salvage II (S)-3- LLO_RS01330 an L-methionyl- an N - an L-glutamyl- propanoate cytidine [acp] diacylglycerol (2Fe-2S)] complex 5'/3'-nucleotidase dCTP dCMP -diaminopimelate containing) 1,2-diacyl-sn- D-hexosaminide CTP 1-phosphate ribonucleoside- IPP cys FAD synthetase: ribF LLO_RS15510 [initiator tRNA Met ] formyltetrahydrofolate in tRNA [tRNA Gln ] uridine kinase: cysteine pyridoxamine hydroxybutanoyl- SurE: surE glycerol 3-phosphate CTP 2',3'- tRNA (cytosine(32) acetate/ 3-oxoacyl- phosphatidylglycerophosphate NAD de novo biosynthesis IscS subfamily 4-amino-2-methyl-5- Asp-tRNA(Asn) type 2 isopentenyl- LLO_RS00065 desulfurase: 5'-phosphate a tRNA precursor a tRNA precursor CoA hydratase: 5' nucleotidase: cyclophosphate /uridine(32)-2'-O)- propionate ACP synthase: LLO_RS01375 I (from aspartate) cysteine FAD cysteine pyrimidinemethanol dUTP diphosphatase: dut penicillin-binding beta-N- glucose-1-phosphate RNA 2',3'-cyclic /Glu-tRNA(Gln) diphosphate LLO_RS15510 a [ThiS sulfur- oxidase: with a 5' with a 5' LLO_RS04580 LLO_RS16780 methyltransferase family kinase: uridine reductase CDP-diacylglycerol-- desulfurase: desulfurase: bifunctional IMP nucleoside triphosphate protein 2: mrdA phosphatidate acetylhexosaminidase: cytidylyltransferase: phosphodiesterase: amidotransferase: Delta-isomerase: a [chaperone- IscS subfamily carrier protein] LLO_RS13570 extension and extension and a (S)-3- methionyl-tRNA TrmJ: trmJ LLO_RS11990 kinase: udk FabG: fabG glycerol-3-phosphate 3- an [2Fe-2S] LLO_RS15510 LLO_RS11720 hydroxymethylpyrimidine pyrophosphohydrolase: [+ 2 isozymes] cytidylyltransferase: nagZ rfbF thpR a 2'-O- gatC gatA gatB LLO_RS01225 ADP]-[disordered- asp cysteine a long 3' trailer short 3' extension hydroxybutanoyl-CoA adenosine GMP formyltransferase: fmt an [RNA]-3'- an L-glutaminyl- propanoyl CMP a (3R)-3- phosphatidyltransferase: cluster protein an [L-cysteine pyridoxamine LLO_RS13645 methyluridine 32 DMAPP form scaffold IscS subfamily kinase/ ribonuclease IMP dehydrogenase: LLO_RS01330 ribunucleoside- Gln phosphate L-aspartate desulfurase: desulfurase]-S- 5'-phosphate (S)-3- dUTP dUMP [tRNA ] hydroxyhexadecanoyl- pgsA protein] complex cysteine phosphomethylpyrimidine P protein a peptidoglycan with an N-acetyl-β- α in tRNA oxidase: nadB LLO_RS11720 oxidase: pdxH hydroxybutanoyl- adenosine deaminase: 5'/3'-nucleotidase guaB an N-formyl- an alcohol CDP- -D-glucose 2'-phosphate [acp] 1-(3-sn- desulfurase: thiamine sulfanyl-L-cysteine kinase: thiD ribonuclease D,D cross-links (meso- D-ala D-hexosamine 2-iminosuccinate an [L-cysteine a carboxy- component: LLO_RS13910 SurE: surE L-methionyl- a tetrahydrofolate a CDP-2,3,4-saturated- 3-hydroxyacyl- phosphatidyl) LLO_RS11720 diphosphate cysteine CoA desulfurase]-S- adenylated-[ThiS PH: rph rnpA met diaminopimelate containing) diacylglycerol ACP -sn-glycerol an [L-cysteine desulfurase: HMP-P PLP dehydrogeanse: adenosine deaminase: 5' nucleotidase: XMP 5-hydroxy-CTP 5-hydroxy-CMP [initiator tRNA ] quinolinate salvage III sulfanyl-L-cysteine sulfur-carrier protein] a tRNA precursor dehydratase 3-phosphate an [Fe-S cluster desulfurase]-S- LLO_RS15510 LLO_RS09265 LLO_RS15655 LLO_RS16780 synthase thiamine a [ThiS sulfur- a tRNA with a short biosynthesis 5-(2-hydroxyethyl) bifunctional FabZ: fabZ sulfanyl-L-cysteine IscS subfamily carrier protein] precursor with 3-hydroxyacyl-CoA 5'/3'-nucleotidase α undecaprenyl-diphospho-N-acetylmuramoyl-L- a peptidoglycan an N-terminal L- 527 34 phosphatidylglycerophosphatase NadA: nadA thiamine cysteine -4-methylthiazole hydroxymethylpyrimidine 3' extension UDP-N-acetyl- -D-glucosamine S-(2-hydroxyacyl) a guanine a cytidine a [protein]-L- sn-glycerol uridine chaperone]-ATP cysteine dehydrogenase: inosine guanosine SurE: surE alanyl-γ-D-glutamyl-L-lysyl- D-alanyl-D-alanine a proteinogenic glutathione alanyl-[S18 protein histidinol a (2E)-hexadec- A: LLO_RS04265 diphosphokinase: desulfurase: cysteine a 5' extension dimer (E. faeciums) glutathione in 16S rRNA in tRNA β-isoaspartate 3-phosphate uridine kinase: quinolinate desulfurase: kinase/ amino acid of 30S ribosome] 2-enoyl-[acp] an L-1- LLO_RS15725 LLO_RS15510 desulfurase: hydroxyethylthiazole LLO_RS11835 5' nucleotidase: ribosomal protein 16S rRNA tRNA (cytidine(34) protein-L- glycerol-3- histidinol phosphomethylpyrimidine ribonuclease purine-nucleoside undecaprenyldiphospho- LLO_RS00065 LLO_RS15510 thiamine LLO_RS11720 kinase: LLO_RS05260 ribonuclease purine-nucleoside LLO_RS16780 (guanine(527)-N(7) -2'-O)- isoaspartate O- dehydrogenase: phosphatidyl- carboxylating IscS subfamily kinase: thiD muramoylpentapeptide beta-N- penicillin-binding S18-alanine N- phosphate enoyl-ACP bis(guanylyl diphosphate a [ThiI sulfur- a carboxy- 4-methyl-5-(2- PH: rph acetoacetyl-CoA phosphorylase: phosphorylase: hydroxyacylglutathione )-methyltransferase methyltransferase: uridine sn-glycerol IscS subfamily P protein protein 2: mrdA acetyltransferase: methyltransferase: dehydrogenase: hisD reductase: nicotinate- molybdopterin) cysteine D-glyceraldehyde gly phosphooxyethyl) LLO_RS09110 LLO_RS09110 acetylglucosaminyltransferase: gamma- kinase: udk biotin biosynthesis from cysteine carrier protein]- adenylated- HMP-PP component: acetyl-CoA C- xanthosine hydrolase: gloB rimI 7 RsmG: rsmG LLO_RS12015 βLLO_RS04160 glpD LLO_RS05360 nucleotide cofactor desulfurase: 3-phosphate LLO_RS10445 glutamyltransferase: ggt [+ 2 isozymes] an N-terminal N-acetyl- an N - a 2'-O- a protein L- - UMP desulfurase: S-sulfanyl- [ThiS sulfur- thiazole rnpA 527 34 his 8-amino-7-oxononanoate I diphosphorylase: D-glyceraldehyde acyltransferase: L-alanyl-[S18 protein methylguanine methylcytidine isoaspartate DHAP enoyl-ACP LLO_RS11720 L-cysteine hypoxanthine guanine LLO_RS11720 tyr carrier protein] LLO_RS11830 of 30S ribosome] in 16S rRNA in tRNA α-methyl ester reductase (8S)-8-amino-7- nadC 3-phosphate thiamine ditrans,octacis-undecaprenyldiphospho-N- a peptidoglycan tetramer a 2-hydroxy a [bis(guanylyl a thiocarboxylated- purine-nucleoside UDP an α-(γ-L-glutamyl) glutathione FabI: fabI phosphatidylserine and oxononanoate phosphate [+ 2 isozymes] acetyl-(N-acetyl-β-D-glucosaminyl)muramoyl-L- L-cysteinylglycine with a D,D cross-link D-ala carboxylate adenosylmethionine- NaMN molybdopterin) [bis-MGD [ThiS sulfur- 1-deoxy-D-xylulose phosphorylase: -L-amino acid phosphatidylethanolamine 2-iminoacetate synthase: thiE alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine (Enterococcus faecium) -8-amino-7- cofactor cofactor carrier protein] 5-phosphate an uncharged acetyl-CoA LLO_RS09110 a palmitoyl-[acp] biosynthesis I oxononanoate nicotinate-nucleotide chaperone]-S- chaperone]- 1-deoxy-D- a thiocarboxylated- tRNA a CDP-diacylglycerol adenylyltransferase: sulfanyl-L-cysteine bis-MGD xylulose 5- [ThiS sulfur- transaminase: bioA thiazole 2-iminoacetate a 1-(1-alkenyl) 2030 a guanine 966 1498 a monocarboxylic a [protein]- dCTP CDP-diacylglycerol--serine (7R,8S)- thiamine phosphate xanthine dethiobiotin a sulfurated glutathione methyl (indol- adenine a uracil nadD synthase: phosphate carrier protein] SAM hypoglycin A -sn-glycero-3- a malonyl-[acp] diaminononanoate [sulfur carrier] 3-yl)acetate in 23S rRNA in 16S rRNA in 16S rRNA acid amide L-histidine dCTP O-phosphatidyltransferase: nicotinate adenine superpathway of purine deoxyribonucleosides degradation phosphocholine 23S rRNA 16S rRNA 16S rRNA amidase: LLO_RS04735 thiamine diphosphate thiamine- sensor histidine deaminase: pssA dinucleotide thiazole malonyl-ACP O- LLO_RS08515 a 3-sn-phosphatidyl- dethiobiotin biosynthesis III phosphate lipoprotein posttranslational modification (adenine(2030)-N(6) (guanine(966)-N(2) (uracil(1498)-N(3))- kinase KdpD: palmitate sulfo-bis(guanylyl synthase: methyltransferase LLO_RS00395 synthase: bioD NAD+ synthase: folate transformations III (E. coli) 2-[(2R,5Z)-2-carboxy- kinase: thiL biotin carboxylesterase: )-methyltransferase )-methyltransferase methyltransferase: amidase: L-serine (Staphylococcus) LLO_RS04735 lysoplasmalogenase: LLO_RS12535 NAD+ synthase: molybdopterin) 4-methylthiazol-5(2H)- 2-(2-carboxy-4- synthase gamma- LLO_RS02735 RlmJ: LLO_RS05950 RsmD: rsmD LLO_RS00445 BioC: bioC a [protein]- dUTP LLO_RS04285 a [prolipoprotein]- urate 2'-deoxyguanosine an N 6 - an N 2 - an N 3 - LLO_RS08535 phosphatidylserine dethiobiotin cofactor ylidene]ethyl phosphate glutamyltransferase: ggt LLO_RS02290 LLO_RS04285 methylthiazol-5- thiamine diphosphate NAD salvage pathway I (PNC VI cycle) L-cysteine BioB: bioB 2030 966 1498 a malonyl-[acp] N-phospho- NAD(+) a tetrahydrofolate HMP-PP 2-[(2R,5Z)- dipyrromethane methyladenine methylguanine methyluracil a monocarboxylate decarboxylase: psd yl)ethyl phosphate 2'-deoxyadenosine methyl ester L-histidine biotin synthase: 2-carboxy-4- cofactor biosynthesis prolipoprotein in 23S rRNA in 16S rRNA in 16S rRNA an L-1- glutathione palmitoyl-CoA synthase nadE methylthiazol-5(2H NAD + diacylglyceryl biotin 5'-deoxyadenosine an unsulfurated sn-glycero-3- (indol-3-yl)acetate MeOH phosphatidylethanolamine biosynthesis thiamine an apo-[hydroxymethylbilane purine-nucleoside met hypoglycin B L-cysteinylglycine a fatty aldehyde BioB: bioB dihydrofolate reductase: 2-(2-carboxy-4- )-ylidene]ethyl NAD(+) transferase: [sulfur carrier] phosphocholine NAD + phosphate synthase]-L-cysteine adenosine phosphorylase: LLO_RS02410 methylthiazol-5- phosphate diphosphatase: nudC LLO_RS00955 synthase: NAD+ synthase: deaminase: LLO_RS09110 9-mercaptodethiobiotin cys glu dihydrofolate reductase: yl)ethyl phosphate a [prolipoprotein]- purine-nucleoside thiE a [hydroxymethylbilane LLO_RS04285 LLO_RS13910 LLO_RS18665 NAD+ synthase: S-1,2-diacyl-sn- 10 1518 1402 2552 a 5,6- phosphorylase: an N - + a single- adenine / a cytidine uridine a 2-O- CTP biotin synthase] ES intermediate phylloquinone NAD(P)H H 20 citrate a DNA segment 2 glyceryl-L-cysteine adenosine phe 1519 dihydrouracil synthase serine LLO_RS04285 LLO_RS09110 formyltetrahydrofolate stranded RNA adenine in 16S rRNA in 16S rRNA in 23S rRNA methylated RNA dCTP glutamate- thiamine hydroxymethylbilane deaminase: 16S rRNA 16S rRNA 23S rRNA in tRNA aconitate BioB: bioB S-adenosyl-L- a 7,8-dihydrofolatehydroxymethyltransferase:a 5-methyltetrahydrofolate thiamine diphosphate NAD(+) synthase: nadE tRNA secreted deaminase: -cysteine glycine cleavage system phosphate nicotinate adenine dinucleotide NMN lipoprotein purine-nucleoside LLO_RS15655 hydratase recombinase LLO_RS04245 biosynthesis I (E. coli) synthase: hemC (adenine(1518)-N(6)/ (cytidine(1402)-2'-O) (uridine(2552)-2'-O) dihydrouridine(20/ ribonuclease A: ligase: gshA methionine salvage II NAD(P)H:quinone RecA: recA LLO_RS00395 biotin protein T: LLO_RS07685 signal phosphorylase: phenylalanine 4- polyribonucleotide adenine(1519)-N(6))- -methyltransferase: -methyltransferase LLO_RS01035 AcnA: acnA 2-[(2R,5Z)- a [hydroxymethylbilane 2-deoxy-α-D- oxidoreductase: 20a) synthase UTP [+ 2 isozymes] [+ 2 isozymes] nicotinate-nucleotide peptidase: LLO_RS09110 monooxygenase: nucleotidyltransferase: pnp dimethyltransferase rsmI RlmE: rlmE a 2-O-methylated [+ 4 isozymes] a DNA segment bifunctional a (6S)-5-formyltetrahydrofolate 2-carboxy-4- synthase] ES intermediate wrbA a 2'-O- a 2'-O- DusA: dusA SAH 3 LLO_RS09980 ribose 1-phosphate LLO_RS13470 adenylyltransferase: 2'-deoxyinosine 6 RsmA: rsmA1518 1402 2552 20 ribonucleoside 5'- D-threo-isocitrate in reverse methylenetetrahydrofolate methylthiazol-5(2H N -dimethyladenine methylcytidine methyluridine a uracil in tRNA γ-L-glutamyl- adenosylhomocysteinase: hydroxymethylbilane nadD phosphopentomutase: monophosphate orientation dehydrogenase/5-formyltetrahydrofolate thiamine )-ylidene]ethyl /N 6 -dimethyladenine 1519 in 16S rRNA in 23S rRNA L-cysteine LLO_RS05565 HMP-PP synthase: hemC an (S-diacyl-sn- a lipoprotein LLO_RS13030 4a-hydroxy-N 10 - a nucleoside a single- thymidylate synthase: thyA methenyltetrahydrofolatecyclo-ligase: LLO_RS13855 + in 16S rRNA adenosylhomocysteinase: thiamine phosphate glyceryl)-L-cysteinyl- tyr NAD(P) phylloquinol diphosphate stranded RNA glutathione cyclohydrolase FolD: folD a [hydroxymethylbilane NaMN nicotinamide signal peptide formyltetrahydrofolate LLO_RS12685 [apolipoprotein] 2-deoxy-D-ribose synthetase: a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate diphosphokinase: synthase] ES intermediate thiamine 4 5-phosphate LLO_RS17480 L-homocysteine LLO_RS15725 apolipoprotein N- phosphate hydroxymethylbilane bifunctional bifunctional acyltransferase: lnt a 1-palmitoyl-2- glutathione thiamine synthase: synthase: hemC deoxyribose- α lipid A RNase R degradation a cytidine 1402 a guanine 46 a ribonucleoside methylenetetrahydrofolate nicotinate nicotinamidase/ an N-acyl-(S-diacyl- purine ribonucleosides degradation UDP-N-acetyl- -D-muramoyl- D-alanyl-D-alanine acyl-sn-glycero-3- a nucleoside 2-hydroxyisobutyramide DNA with lesion propionamide synthase: diphosphate thiE a peptide phosphate γ substrate RNA in 16S rRNA in tRNA thiamine diphosphate dehydrogenase/ a holo-[hydroxymethylbilane phosphoribosyltransferase: pyrazinamidase: pncA sn-glyceryl)-L- L-alanyl- -D-glutamyl-L-lysine phosphocholine triphosphate 5'-monophosphate excinuclease amidase: gshB aldolase: 16S rRNA tRNA 5' nucleotidase: amidase: biosynthesis II (Bacillus) cytidylyl molybdenum methenyltetrahydrofolate synthase] LLO_RS04035 cysteinyl-[lipoprotein] nucleoside triphosphate LLO_RS08515 malonate (cytosine(1402)-N(4) (guanosine(46)-N7) LLO_RS16780 LLO_RS08515 ABC subunit cyclohydrolase FolD: folD thiamine LLO_RS09115 UDP-N-acetylmuramoyl- lipid IV(A) pyrophosphohydrolase: glutathione met 2-(2-carboxy-4- cofactor sulfurylation decarboxylase nicotinate adenosine ribonuclease )-methyltransferase -methyltransferase amidase: UvrC: uvrC amidase: phosphate tripeptide--D-alanyl- palmitoyltransferase LLO_RS01330 5'/3'-nucleotidase methylthiazol-5- activation 10 R: rnr 4 RsmH: rsmH 7 TrmB: trmB LLO_RS08535 [+ 2 isozymes] LLO_RS08535 HMP-PP cytidylyl molybdenum an N -formyltetrahydrofolate menaquinol-7 biosynthesis D-glyceraldehyde an N - an N - SurE: surE methionine yl)ethyl phosphate thiamine- acetaldehyde D- alanine ligase: PagP: pagP a nucleoside 5'- 2-hydroxy-2- DNA without cofactor (trioxo) 3-phosphate adenosine deaminase: 1402 46 propanoate 3'-dephospho-CoA folate polyglutamylation 6 37 methylcytidine methylguanine a ribonucleoside adenosyltransferase: phosphate N -L-threonylcarbamoyladenosine LLO_RS13995 monophosphate methylpropanoate lesion hypothetical all-trans- LLO_RS13910 a hepta-acylated in 16S rRNA in tRNA LLO_RS12690 thiamine thioredoxin kinase: thiL -modified tRNA biosynthesis a 2-acyl-sn-glycero- a nucleoside 5'- protein: heptaprenyl 1,4-dihydroxy- adenosine deaminase: lipid A (E. coli) a diribonucleotide tetrahydrofolate salvage from phosphate an [MCD cofactor pathway UDP-N-acetyl-α-D-muramoyl-L-alanyl- 3-phosphocholine monophosphate LLO_RS12895 thiamine a tetrahydrofolate diphosphate 2-naphthoate LLO_RS15655 5,10-methenyltetrahydrofolate SAM synthase: chaperone]-MCD 2'-(5''-triphospho- γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine α glutathione- thiamine diphosphate thiE cysteine -D-ribosyl)-3'- an oxidized ATP thr acetyl-CoA a 5,10- diphosphate desulfurase: dephospho-CoA peroxide thioredoxin serine bifunctional xanthosine adenosine inosine guanosine methenyltetrahydrofolate malonate redox reactions salvage I hydroxymethyltransferase: an [HPr]- phosphoenol a 1-palmitoyl-2- a 23S rRNA a cytosine 967 a guanine 37 an insertion sequence bifunctional LLO_RS15510 tetrahydrofolate lipid II NAD(P)H a plastoquinone H + 4-guanidinobutyramide thiamine A acyl-sn-glycero-3- 1911/1915/1917 pyruvate 2-chloroacetate decarboxylase thiamine LLO_RS04245 synthase/ 10 L-histidine pyruvate uridine in 16S rRNA in tRNA element IS30 methylenetetrahydrofolate phosphate IscS subfamily GSSG an N - demethylmenaquinol-7 threonylcarbamoyl- holo-[acyl- phosphocholine 23S rRNA 16S rRNA tRNA transposase: amidase: acetolactate haloacid dehydrogenase/ glutathione- cysteine thioredoxin- lipoate biosynthesis dihydrofolate formyltetrahydrofolate AMP synthase: purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside thiamine- pseudouridine(1911/ (cytosine(967)-C(5) (guanosine(37)-N1) LLO_RS08515 synthase dehalogenase methenyltetrahydrofolate glutaredoxin carrier-protein] disulfide a 5,10- synthase: folC bifunctional LLO_RS09065 phosphorylase: phosphorylase: phosphorylase: phosphorylase: phosphoenolpyruvate- lipid IV(A) NAD(P)H:quinone LLO_RS07260 desulfurase: and incorporation I bifunctional 1915/1917) )-methyltransferase -methyltransferase amidase: large subunit: type II: redox reactions phosphate synthase: mdcG thiamine reductase: methylenetetrahydrofolate demethylmenaquinone LLO_RS09110 LLO_RS09110 LLO_RS09110 LLO_RS09110 [+ 14 isozymes] 10 cyclohydrolase FolD: folD LLO_RS11720 tetrahydrofolate threonylcarbamoyl- UTP and CTP dephosphorylation I -protein palmitoyltransferase oxidoreductase: an N - kinase: thiL [a holo malonate glutathione- synthase RluD: rluD RsmB: rsmB 1 TrmD: trmD an insertion LLO_RS08535 LLO_RS15860 LLO_RS11545 phosphate trxB methyltransferase/2- 1911/ 967 an N - glutathione a [cytidylyl molybdenum bifunctional synthase/ AMP synthase: phosphotransferase: ptsP PagP: pagP wrbA a pseudouridine a 5-methylcytosine formyltetrahydrofolate decarboxylase disulfide an octanoyl-[acp] a tetrahydrofolate 37 sequence IS30 with 4-guanidinobutanoate (S)-2-acetolactate glycolate thiamine cofactor chaperone]- thiamine- tetrahydrofolate dihydrofolate methoxy-6-polyprenyl- LLO_RS17060 UTP α-D-ribose-1-phosphate 1915/1917 in 23S rRNA in 16S rRNA methylguanine acyl-carrier-protein] reductase: lipoyl(octanoyl) integrated transposon phosphoribosylglycinamide diphosphate cytidylyl molybdenum phosphate synthase/ synthase: folC 1,4-benzoquinol an [HPr protein]- a 2-acyl-sn-glycero- in tRNA gorA transferase lipid II + formyltransferase: purN kinase: thiL a reduced dihydrofolate methylase UbiE: ubiE CTP synthase: pseudouridine phosphopentomutase: N π -phospho- pyruvate B a plastoquinol NAD(P) a reduced cofactor (sulfo-dioxo) LipB: lipB an N 10 - (L-threonylcarbamoyl) 3-phosphocholine thioredoxin a [lipoyl-carrier protein] synthase: folC degradation glutaredoxin thiamine adenylate LLO_RS05335 LLO_RS13030 L-histidine a tetrahydrofolate N 6 -octanoyl-L-lysine formyltetrahydrofolate menaquinol-7 diphosphate a 5,10- tRNA (adenosine(37)-N6)- UDP NADP glutathione pseudouridine D-ribose 5-phosphate glutaredoxin menaquinol-9 biosynthesis lipoyl methylenetetrahydrofolate CTP biosynthesis threonylcarbamoyltransferase pseudouridine an (R)-2- a 5' triphospho- guanine 37 a negatively an adenine 34 an adenosine 34 3: grxC menaquinol-8 biosynthesis synthase: lipA a proteinogenic leukotriene-C4 glycyl-glycine glutathione dihydrolipoamide malonate complex dimerization kinase: halocarboxylate [mRNA] in tRNA Phe supercoiled DNA in tRNA in [tRNA Arg2 ] a protein with a [lipoyl-carrier amino acid demethylmenaquinol-9 NAD + menaquinol-6 biosynthesis subunit type 1 TsaB: tsaB LLO_RS02315 dihydrolipoyllysine- tRNA DNA biotin-independent tRNA tRNA 6 UMP RNA reduced L- protein]-N -[(R)- pseudouridine residue (guanosine(37)-N1) topoisomerase malonate adenosine(34) adenosine(34) bifunctional demethylmenaquinol-8 NAD(+) kinase: [+ 2 isozymes] CDP HAD family pyrophosphohydrolase: cysteine residues dihydrolipoyl]-L-lysine 6 5'-phosphate IV subunit A: parC demethylmenaquinone bifunctional LLO_RS01280 an N -L- 5'/3'- gamma- acetyltransferase: LLO_RS00965 -methyltransferase decarboxylase: deaminase deaminase demethylmenaquinol-6 37 gamma- hydrolase: methyltransferase/2- demethylmenaquinone + threonylcarbamoyladenine nucleotidase glutamyltransferase: ggt aceF a 5'-phospho- 1 TrmD: trmD [+ 2 isozymes] LLO_RS12910 mdcA TadA: tadA TadA: tadA NADP bifunctional pseudouridine- glutamyltransferase: ggt LLO_RS11285 an N - a hypoxanthine an inosine 34 methoxy-6-polyprenyl- methyltransferase/2- in tRNA SurE: surE S-acetyldihydrolipoamide [mRNA] 37 a relaxed DNA acetate demethylmenaquinone 5'-phosphate methylguanine 34 in tRNAs in [tRNA Arg2 ] methoxy-6-polyprenyl- CMP Phe 1,4-benzoquinol methyltransferase/2- 5' nucleotidase: glycosidase: γ-L-glutamyl- in tRNA 1,4-benzoquinol α γ L-cysteinylglycine an (S)-2- methylase UbiE: ubiE methoxy-6-polyprenyl- 5'/3'- LLO_RS16780 LLO_RS02310 an -( -L-glutamyl) glycylglycine a halide anion methylase UbiE: ubiE leukotriene-D4 hydroxycarboxylate menaquinol-9 1,4-benzoquinol nucleotidase uridine -L-amino acid menaquinol-8 queuosine biosynthesis I (de novo) uracil methylase UbiE: ubiE SurE: surE menaquinol-6 5' nucleotidase: an (S-diacyl-sn- a nucleoside 13 preQ an L-1- a 1-O-(alk-1-enyl)-sn-glycero- an (S)-2- 3-phenyl-2- (3R,7Z,10Z,13Z,16Z)-3- a uridine a [phospholipid]- 0 LLO_RS16780 glyceryl)-L-cysteinyl- cyclic 3',5'- L-ornithine wound RNA NADPH-dependent 7- phosphatidylethanolamine 3-phosphoethanolamine halocarboxylate oxopropanoate hydroxydocosatetraenoyl-CoA in tRNA oleate [apolipoprotein] monophosphate tRNA cyclopropane ATP- cyano-7-deazaguanine cytidine acetoacetyl-CoA 4-hydroxyphenylpyruvate 3',5'-cyclic-nucleotide pseudouridine(13) arginine N- fatty acyl dependent reductase QueF: queF HAD family reductase: phbB lysoplasmalogenase: dioxygenase: hppD phosphodiesterase: synthase TruD: succinyltransferase: phospholipid RNA helicase preQ apolipoprotein N- hydrolase: [+ 2 isozymes] 1 LLO_RS02290 LLO_RS03475 LLO_RS04550 LLO_RS08720 synthase: cfa DbpA: dbpA acyltransferase: lnt (2-hydroxyphenyl) (7Z,10Z,13Z,16Z)-3- 2 LLO_RS11285 a nucleoside 5'- a pseudouridine 13 N -succinyl- a [phospholipid]- tRNA guanosine(34) acetate oxodocosatetraenoyl-CoA an unwound RNA monophosphate in tRNA L-ornithine dihydrosterculate transglycosylase Tgt: tgt reactive oxygen species degradation Detoxification arsenate arsenate phenylmercury acetate degradation an N-acyl-(S-diacyl- a 2-acyl-1-lyso- sn-glycero-3- an (S)-2- a 7-aminomethyl-7- detoxification detoxification sn-glyceryl)-L- a fatty aldehyde a halide anion phosphatidylethanolamine phosphoethanolamine hydroxycarboxylate deazaguanosine 34 in tRNA superoxide III (thioredoxin) II (glutaredoxin) mercuriphenyl cysteinyl-[lipoprotein] acetate tRNA preQ1(34) S- superoxide arsenate arsenate adenosylmethionine dismutase: arsenate arsenate 3-methyl-2- 5,10-methylene- D-glyceraldehyde D-sedoheptulose poly-3- (S)-3-hydroxy- a uracil 1939 24-methylenecholesterol (E)-caffeoyl-CoA N5-CAIR ribosyltransferase- LLO_RS00335 reductase reductase oxobutanoate tetrahydromethanopterin 3-phosphate 7-phosphate hydroxyoctanoate isobutanoate in 23S rRNA an L-amino acid thr 5-(carboxyamino) isomerase QueA: queA hydrogen (glutaredoxin) (glutaredoxin) 7-dehydrocholesterol 3-hydroxyisobutyrate 23S rRNA electron transfer (uracil(1939)-C(5)) flavoprotein amino acid L-threonine 3- imidazole 34 : arsC : arsC 2+ 3-methyl-2-oxobutanoate reductase: dehydrogenase: an epoxyqueuosine in tRNA peroxide acetate benzene Hg dehydrogenase: dehydrogenase: arsenite arsenite hydroxymethyltransferase: polyhydroxyalkanoate LLO_RS06795 mmsB -methyltransferase subunit alpha: ribonucleotide transketolase: tkt LLO_RS03135 tdh epoxyqueuosine mercuric panB depolymerase: phaZ ergosta-5,7,24(28) (S)-methylmalonate- RlmD: rlmD LLO_RS04460 mutase: purE catalase: a 5-methyluracil 1939 a 2-oxo reductase: β hydrocaffeoyl-CoA aminoacetone CAIR reductase QueH: LLO_RS06970 -trien-3 -ol semialdehyde in 23S rRNA carboxylate LLO_RS15045 LLO_RS01615 D-ribose 5- D-xylulose poly-3- poly-3- H O hydroxyl radical 0 2-dehydropantoate THMPT 34 O 2 arsenite arsenite Hg phosphate 5-phosphate hydroxyoctanoate hydroxyoctanoate a queuosine in tRNA 2

8-oxo-(d)GTP detoxification I lipid IV (E. coli) 1,2-dipalmitoyl- D-xylulose D-erythrose D-threo-7,8- (9Z,12Z,15Z,18Z,21Z)-3- 3-heptaprenyl-4- a double-stranded a [protein] (L-serine/L- A an acyl phosphate N-ethylmaleimide (R)-lactate phosphatidylserine 5-phosphate 4-phosphate dihydroneopterin oxotetracosapentaenoyl-CoA hydroxybenzoate oligonucleotide threonine) phosphate N-end rule pathway I (prokaryotic) arginine alkene dGTP acetoacetyl-CoA 4-hydroxy-3- oligoribonuclease: protein D-2-hydroxyacid dependent GTP acylphosphatase: leucyl/ lipid IV(A) reductase: phbB polyprenylbenzoate phosphatase: reductase: dehydrogenase: dihydroneopterin orn LLO_RS05280 acid resistance palmitoyltransferase transketolase: tkt [+ 2 isozymes] decarboxylase: ubiD LLO_RS16080 LLO_RS10895 LLO_RS07290 phenylalanyl- aldolase: folB PagP: pagP (3R,9Z,12Z,15Z,18Z,21Z)-3- a nucleoside 5'- tRNA--protein arg 8-oxo-dGTP 8-oxo-GTP 2-heptaprenylphenol a carboxylate a [protein] Ser/Thr N-ethylsuccinimide pyruvate hydroxytetracosapentaenoyl-CoA monophosphate transferase: biosynthetic a [protein] an N-terminal LLO_RS11810 arginine 8-oxo-dGTP 2-palmitoyl-sn-glycero- lipid IV D-glyceraldehyde 6-(hydroxymethyl) glycolaldehyde N-terminal L- B F6P arginyl-[protein] decarboxylase: diphosphatase 3-phosphoserine 3-phosphate -7,8-dihydropterin leucyl-L-arginine speA MutT: mutT agmatine 8-oxo-GMP 8-oxo-dGMP a 1-palmitoyl-2- DNA combined with leucyl/ lipid IV (E. coli) a 4-hydroxy-3- (R)-3- A a homogalacturonan desmosterol uroporphyrinogen-I Ins(1)P NaMN MeOH phenylalanyl- acyl-sn-glycero-3- exogenous DNA to form polyprenylbenzoate hydroxybutanoate phosphocholine tRNA--protein a recombinational junctionHolliday junction 7-dehydrocholesterol 4-hydroxy-3- uroporphyrinogen 3-hydroxybutyrate inositol 5' nucleotidase: catalase: transferase: resolvase RuvX: ruvX reductase: polyprenylbenzoate decarboxylase: dehydrogenase: monophosphatase: lipid IV(A) polygalacturonase: LLO_RS16780 LLO_RS06970 LLO_RS11810 a [protein] Inorganic Nutrient Metabolism LLO_RS06795 decarboxylase: ubiD LLO_RS12725 LLO_RS03215 an N-terminal palmitoyltransferase LLO_RS08640 crossover junction LLO_RS11710 N-terminal L- endodeoxyribonuclease a 2-(all-trans- β-D- L-lysyl-[protein] leucyl-L-lysine PagP: pagP 7-dehydrodesmosterol coproporphyrinogen I acetoacetate myo-inositol formaldehyde thiosulfate oxidation III RuvC: ruvC polyprenyl)phenol ribosylnicotinate sulfur reduction resolution of recombinational (multienzyme complex) urea cycle junction formation II (via polysulfide) a 2-acyl-sn-glycero- lipid IV a homogalacturonan a homogalacturonan 3-phosphocholine B of two intact strands a [SoxY protein]-L-cysteine S 0 arg ammonium a generic 2-amino-6-[1-hydroxyethyl]- N,N',N''- (9Z,12Z,15Z,18Z)-3- 3-nonaprenyl-4- a uridine 55 a 2,3,4-saturated (3R CDP-α-D-glucose glutamine- triacetylchitotriose Ins(2)P ethanol polynucleotide substrate 7-methyl-7,8-dihydropterin oxotetracosatetraenoyl-CoA hydroxybenzoate in tRNA )-3-hydroxyacyl-CoA CDP- argininosuccinate hydrolyzing a polysulfide 2-amino-4-hydroxy-6- acetoacetyl-CoA 4-hydroxy-3- tRNA acetoacetyl-CoA inositol glucose 4,6- a [SoxY protein]-S- lyase: argH carbamoyl- catalase: sulfosulfanyl-L-cysteine hydroxymethyldihydropteridine beta-N- reductase: phbB polyprenylbenzoate pseudouridine(55) reductase: phbB monophosphatase: dehydratase: phosphate synthase sulfhydrogenase S1/P1 nuclease: LLO_RS06970 diphosphokinase: folK acetylhexosaminidase: [+ 2 isozymes] decarboxylase: ubiD synthase TruB: truB [+ 2 isozymes] LLO_RS11710 rfbG small subunit: carA subunit delta: LLO_RS07750 [1-(2-amino-7-methyl-4-oxo- cytochrome c: LLO_RS12425 nagZ (3R,9Z,12Z,15Z,18Z)-3- a pseudouridine 55 a 2,3,4-saturated CDP-4-dehydro-6- L-ornithine carbamoyl- 7,8-dihydro-3H-pteridin- 2-nonaprenylphenol myo-inositol acetaldehyde LLO_RS11940 L-arginino-succinate hydroxytetracosatetraenoyl-CoA in tRNA 3-oxoacyl-CoA deoxy-α-D-glucose phosphate synthase 6-yl)]ethyl diphosphate a polysulfide N,N'- N-acetyl-D- large subunit: carB a [SoxY protein]-S- a [SoxY protein]-S a 5'-phosphomononucleotide a 5'-phosphooligonucleotide diacetylchitobiose glucosamine disulfanyl-L-cysteine -sulfanyl-L-cysteine ornithine carbamoyl phosphate argininosuccinate carbamoyltransferase: 2,5-diamino-6-(5- 1915 synthase: 38-40 a pseudouridine 3-decaprenyl-4- (6R)-L-erythro-5,6,7,8- cellulose argF polyphosphate phospho-D-ribitylamino) a uridine in tRNA isofucosterol uroporphyrinogen-III oxaloacetate pyrazinamide LLO_RS11575 in 23S rRNA hydroxybenzoate tetrahydrobiopterin metabolism pyrimidin-4(3H)-one RluA family pseudouridine 23S rRNA L-citrulline bifunctional 7-dehydrocholesterol 4-hydroxy-3- uroporphyrinogen pteridine endoglucanase: amidase: a [SoxY protein]-S-(2- synthase: LLO_RS03050 (pseudouridine(1915)- 2-methylcitrate long chain diaminohydroxyphosphoribosylaminopyrimidine reductase: polyprenylbenzoate III methylase: reductase: LLO_RS11965 LLO_RS08515 sulfodisulfanyl)-L-cysteine N(3))-methyltransferase synthase: prpC polyphosphate deaminase/5-amino-6-(5-phosphoribosylamino) tRNA pseudouridine(38- LLO_RS06795 decarboxylase: ubiD LLO_RS16955 LLO_RS00890 [+ 2 isozymes] phosphate RlmH: rlmH uracil reductase RibD: ribD 40) synthase TruA: truA an N 3 - 1,2-dihydroxypropane- a cellodextrin pyrazine-2- sulfur reduction I acquisition 5-amino-6-(5-phospho- 38-40 5-dehydroavenasterol 2-decaprenylphenol precorrin-2 L-erythro-biopterin a pseudouridine in tRNA methylpseudouridine 1915 1,2,3-tricarboxylate carboxylate D-ribitylamino)uracil a phosphate polyphosphate in 23S rRNA 0 S monoester kinase 1: ppk1 sulfhydrogenase acid 10 34 N,N'- UDP-N-acetyl- subunit delta: phosphatase: phosphatidylglycerolphosphate 4a-hydroxy-N - a 5-carboxymethylaminomethyluridine UTP GDP-β-L-fucose Leu 7-dehydrocholesterol α-D-glucosamine (R)-mevalonate methylglyoxal LLO_RS14010 (1-oleoyl, 2-palmitoyl) formyltetrahydrofolate in tRNA diacetylchitobiose nucleoside triphosphate LLO_RS12425 long chain UDP-N- phosphate tRNA (cytidine(34) 7-dehydrocholesterol beta-N- mevalonate GDP-L-fucose hydrogen sulfide 4a-hydroxytetrahydrobiopterin pyrophosphohydrolase: acetylglucosamine glyoxalase: polyphosphate phosphatidylglycerophosphatase -2'-O)- reductase: acetylhexosaminidase: kinase: synthase: dehydratase: LLO_RS06900 LLO_RS01330 2-epimerase (non- LLO_RS03915 A: LLO_RS04265 methyltransferase: LLO_RS06795 nagZ LLO_RS10615 LLO_RS16030 N-acetyl-D- UMP hydrolyzing): wecB GDP-4-dehydro- 1-oleoyl-2-palmitoyl- an N 10 -formyl- LLO_RS12015 UDP-N-acetyl-α- (R)-5- a 5-carboxymethylaminomethyl- cholesterol α-D-rhamnose (R)-lactate 7,8-dihydrofolate glucosamine phosphomevalonate phosphatidylglycerol 2'-O-methyluridine 34 in tRNA Leu D-mannosamine a reduced an amino plastocyanin a dicarboxylate a dicarboxylate guanine acid a branched- an oxidized an amino an amino lipid II (meso a quaternary an an inorganic a C4- chain plastocyanin an amino an amino a lipopolysaccharide a lipopolysaccharide queuosine a nucleotide diaminopimelate ammonium oligopeptide anion dicarboxylate acid acid Peptide acid acid amino acid chromate chromate a lipopolysaccharide phosphate phosphate containing) compound a polysaccharide an amino acid predicted predicted ABC predicted ABC ABC cytochrome RS13980 RS15905 RS15930 RS04210 RS04145 RS03510 RS13685 RS02365 RS11225 efflux transporter of efflux transporter of RS10325 RS14765 RS07185 RS13900 RS00320 RS14405 transporter RS15260 RS10570 RS14025 RS12480 c oxidase a lipopolysaccharide a lipopolysaccharide of an amino acid a branched- an an inorganic a C4- an amino an amino lipid II (meso a quaternary chain queuosine Peptide a polysaccharide oligopeptide anion dicarboxylate chromate chromate a lipopolysaccharide a nucleotide acid acid an amino an amino diaminopimelate ammonium amino acid O phosphate phosphate an amino acid a lipopolysaccharide a lipopolysaccharide 2 acid acid containing) compound an amino guanine H O 2 acid a dicarboxylate a dicarboxylate This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.