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Volume 42, Number 4, 2010 BULGARIAN CHEMICAL COMMUNICATIONS 2010 Volume 42 / Number 4 Journal of the Chemical Institutes of the Bulgarian Academy of Sciences and of the Union of Chemists in Bulgaria Announcement Seventh National Conference on Chemistry and 2nd International Conference on Green Technologies and Environmental Protection INVITATION 2. Organic chemistry: V. Dimitrov, P. K. The Union of Chemists in Bulgaria (UCB) Sharma extends a cordial invitation to all scientists 3. Inorganic chemistry: D. Todorovsky, R. in the field of chemistry to participate in the K. Sharma Seventh National Conference on Chemistry 4. Analytical chemistry: D. Tsalev, R. K. to be held at the University of Chemical Mahajan Technology and Metallurgy in Sofia 5. Catalysis: S. Damyanova, R. D. Kaushik (Bulgaria) from 26 to 29 May 2011. 6. Chemical engineering: V. Beshkov, M. Parallely the 2nd International Conference A. Abdullaha on Green Technologies and Environmental 7. Chemistry and environmental protection: Protection co-organized with the Chaudhary Y. Pelovsky, A. Mittal Charan Singh University, Meerut (India) 8. Polymers (plastics, rubbers, chemical and Devam Foundation – Bulgarian-Indian fibres, cellulose): N. Dishovsky, R. K. Soni Art & Culture Centre will take place. 9. Chemical technologies: G. Vissokov, A. Muddoo ORGANIZATION INSTITUTIONS 10. Oil processing, petrochemistry and Union of Chemists in Bulgaria, Union of organic synthesis: G. Cholakov, A. P. Gupta Scientists in Bulgaria, Bulgarian Academy 11. Chemical education: B. Toshev, A. K. of Sciences, Chaudhary Charan Singh Halve University, Meerut (India), Devam Foundation, University of Chemical GENERAL SCOPE Technology and Metallurgy, Sofia, Prof. A. The Seventh National Conference on Zlatarov University of Burgas, Faculty of Chemistry is organized within the Chemistry at St. K. Ohridski University of International Year of Chemistry 2011 and Sofia, Faculty of Chemistry at P. together with an International Conference Hilendarski, University of Plovdiv, Faculty on Green Technologies and Environmental of Chemistry at K. Preslavski University of Protection. The main objective of the Shumen, Faculty of Chemistry at N. Rilski conference is to discuss all fields of Southwest University of Blagoevgrad, chemistry related to innovative and current University of Food Technologies, Plovdiv. topics, with emphasis on the latest developments in chemistry and relation to SYMPOSIA TITLES AND CHAIRS everyday life and clean environment. 1. Physical chemistry and electrochemistry: Multidisciplinary topics with related fields R. Raichev, R. Jain such as theoretical chemistry, chemical 265 engineering, physics, earth and life sciences REGISTRATION FEE AND PAYMENT will be strongly encouraged. High-level Conference ticket for participants (EURO). scientific contributions including basic This includes welcome reception drink, research and industrial requirements will be book of abstracts and conference particularly appreciated. Papers on the programme, coffee, refreshments and following topics are invited: sightseeing tour of Sofia: Agrochemistry: fertilisers and pesticides; early payment -120 Analytical chemistry; Biochemistry: payment after 31 January 2011-130 biomaterials and biotechnology; Catalysis; payment at conference site – 140. Ceramics and silicate chemistry; Chemical Payments should be made only by bank engineering; Chemistry and technology of transfer to the following account: polymers; Computational chemistry and molecular modelling; Electrochemistry; Union of Chemists in Bulgaria Inorganic chemistry; Management in IBAN: BG68UNCR96601018407500 chemical industries; BIC: UNCRBGSF Mineral processing; Natural products; New UniCredit Bulbank, 1 Ivan Vazov St., materials; Organic chemistry; 1000 Sofia, Bulgaria Organometallics; Petrochemistry; Pharmaceuticals; Physical chemistry; Pulp ACCOMMODATION and paper technology; Radiochemistry; A very wide range of accommodation from Solid state chemistry; Supramolecular 5 star hotels to student hostels will be chemistry; Textile and leather chemistry. available during the conference. Please contact the conference organizer at the web SCIENTIFIC PROGRAMME site of the conference: The programme of the conference will http://7ncc.unionchem.org. consist of plenary lectures (40 min), keynote lectures (30 min), oral presentations KEY DATES (15 min), and posters. All the presentations 15 January 2011: Submission of abstracts should be related to recent and innovative 31 January 2011: Early payment studies. 1 May 2011: Final programme at the web site LANGUAGE 26 May 2011: Welcome to 7NCC The official language of the conference is English. CONTACT US Prof. V. Beschkov, DSc CONTRIBUTIONS Chairman of the Organizing Committee The selection of the oral and poster Institute of Chemical Engineering, presentations will be based on half-page Bulgarian Academy of Sciences abstracts. Acad. G. Bonchev St., Bldg. 103, 1113 New methods, approaches and applications Sofia, Bulgaria will be encouraged. Contributions should tel: +359-2-8702088, fax: +359-2-8707523 comply with the scope of the conference. e-mail: [email protected] Submissions should be made online using the application form available at the web Assoc. Prof. Ch. Bonev, PhD site: http://7ncc.unionchem.org. The Scientific Secretary reviewing process will be carried out online Institute of Catalysis, Bulgarian Academy via the internet. After evaluation of the of Sciences contributions the programme will be made Acad. G. Bonchev St., Bldg. 11, 1113 Sofia, available at the conference web site. Bulgaria tel: +359-2-9792591, fax: +359-2-9712967 BOOK OF ABSTRACTS e-mail: [email protected] A book of abstracts and a printed programme will be handed out to the participants upon registration at the conference site. 266 Assoc. Prof. L. Fachikov, PhD Secretary University of Chemical Technology and Metallurgy 8 St. K. Ohridski Blvd., 1756 Sofia, Bulgaria tel: +359-2-8681120, +359-2-8163251, fax: +359-2-8685488 e-mail: [email protected] Mr. N. Naydenov, Dipl. Eng. Secretary Union of Chemists in Bulgaria 108 Rakovski St., 1000 Sofia, Bulgaria tel/fax: +359-2-9875812 e-mail: [email protected] 267 Bulgarian Chemical Communications, Volume 42, Number 4 (pp. 268-273) 2010 A rapid, sensitive, and direct quantification of tamosulosin in human plasma through LC-ESI-MS/MS for the purposes of a bioequivalence study M. L. Kundlik1, B. H. Zaware2 S. R. Kuchekar 1* 1Padmashri Vikhe Patil College, Pravaranagar, Loni Kurd, Pin-413713, Dis-Ahmednagar, Maharastra State, India 2 New Arts, Commerce and Science College of Ahmedanagar-414 001, Maharastra State, India. Received August 26, 2010, accepted September 9, 2010 A high-throughout bioanalytical method based on a solid phase extraction (SPE) and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis has been developed and validated for the quantification of tamosulosin in heparinzed human plasma. Plasma samples, without a drying and reconstitution step, were extracted by a simple SPE. The analytes and tamosulosin D4 isotope (internal standard, IS) were chromatographed on a Betabasic-8 column. The total chromatographic run time was 1.8 min per sample. The response was a linear function of concentration in the range of 0.075–50.0 ng/ml, with correlation coefficient ≥0.9992. The assay has excellent characteristics and was successfully applied to bioequivalence study samples for estimation of tamosulosin in healthy human subjects. Key words: human plasma; LC-MS/MS; tamosulosin; positive ion electrospray. biological fluids. LC-fluorescence detector [4] and INTRODUCTION LC-MS/MS [4-6] methods are inadequate because of The symptoms, associated with benign prostatic the low sensitivity (LLOQ>0.2 ng/ml), high hyperplasia (BPH), are related to the bladder outlet injection volume (>10 µl), long chromatographic run obstruction, which is comprised of two underlying time (>2.5 min) and large volume of plasma (>0.5 components: static and dynamic. The static ml), required for the analysis. Hence, these methods component is related to the increase in the prostate allow for limited numbers of sample analysis in a size, caused partly by a proliferation of smooth day, which is not enough for day to day analysis and muscle cells in the prostatic stroma. However, the commercial utilization in the pharmacokinetics severity of BPH symptoms and the degree of the studies. The reported LC-MS and LC-MS/MS urethral obstruction do not correlate well with the methods [7-9] are sensitive enough but all these size of the prostate [1, 2]. The dynamic component technique require laborious extraction procedure is a function of increase in the smooth muscle tone such as the liquid-liquid extraction (LLE), involving in the prostate and bladder neck, leading to time-consuming and error-prone solvent evaporation constriction of the bladder outlet. Smooth muscle and reconstitution steps, high injection volume, and tone is mediated by the sympathetic nervous large volume of plasma for the analysis. Therefore, stimulation of the alpha 1 adrenoceptors, which are it was necessary to develop a simple, rapid and abundant in the prostate, prostate capsule, prostatic sensitive analytical method with minimum plasma urethra, and bladder neck. Blockage of these requirement for extraction and short run time adrenoceptors can lead to smooth muscles in the method to quantify the tamosulosin in the human bladder neck and relaxation in the prostate which plasma. results in improvement of the urine flow rate and We report a new validated LC-MS/MS method reduction
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