Author Manuscript Published OnlineFirst on July 28, 2017; DOI: 10.1158/0008-5472.CAN-17-0391 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Src inhibits the Hippo tumor suppressor pathway through tyrosine phosphorylation of Lats1 Yuan Si1, Xinyan Ji1, Xiaolei Cao1, Xiaoming Dai1, Lingyi Xu1, Hongxia Zhao1, Xiaocan Guo1, Huan Yan1, Haitao Zhang1, Chu Zhu1, Qi Zhou1, Mei Tang1, Zongping Xia1, Li Li3, Yu-Sheng Cong3, Sheng Ye1, Tingbo Liang2, Xin-Hua Feng1, Bin Zhao1, 3, * 1Life Sciences Institute and Innovation Center for Cell Signaling Network 2Department of Hepatobiliary and Pancreatic Surgery and the Key Laboratory of Cancer Prevention and Intervention, The Second Affiliated Hospital, School of Medicine Zhejiang University, Hangzhou, Zhejiang 310058, China 3Institute of Aging Research, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China *Correspondence: Bin Zhao, Life Sciences Institute, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang, China. Phone: 86-571-88208545; Email:
[email protected] Key words: Src, Hippo pathway, Lats1, cell adhesion, tumorigenesis Running title: Lats1 phosphorylation by Src promotes tumorigenesis Financial support: This work was supported by grants to B. Zhao from the National Natural Science Foundation of China General Projects (31471316) and Excellent Yong Scholars Project (31422036), the State Key Development Program for Basic Research of China (2013CB945303), the National Natural Science Foundation of China International Collaboration Project (31661130150), the 111 project (B13026), and the Qianjiang Scholar Plan of Hangzhou, the Thousand Young Talents Plan of China, and the Newton Advanced Fellowship from the Academy of Medical Sciences, UK. And grant from the National Natural Science Foundation of China to S.