Associated Lymphoid Tissue in Chickens and Turkeys Andrew Stephen Fix Iowa State University
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Appendiceal GCC and LAMN Navigating the Alphabet Soup in the Appendix
2018 Park City AP Update Appendiceal GCC and LAMN Navigating the Alphabet Soup in the Appendix Sanjay Kakar, MD University of California, San Francisco Appendiceal tumors Low grade appendiceal mucinous neoplasm • Peritoneal spread, chemotherapy • But not called ‘adenocarcinoma’ Goblet cell carcinoid • Not a neuroendocrine tumor • Staged and treated like adenocarcinoma • But called ‘carcinoid’ Outline • Appendiceal LAMN • Peritoneal involvement by mucinous neoplasms • Goblet cell carcinoid -Terminology -Grading and staging -Important elements for reporting LAMN WHO 2010: Low grade carcinoma • Low grade • ‘Pushing invasion’ LAMN vs. adenoma LAMN Appendiceal adenoma Low grade cytologic atypia Low grade cytologic atypia At minimum, muscularis Muscularis mucosa is mucosa is obliterated intact Can extend through the Confined to lumen wall Appendiceal adenoma: intact muscularis mucosa LAMN: Pushing invasion, obliteration of m mucosa LAMN vs adenocarcinoma LAMN Mucinous adenocarcinoma Low grade High grade Pushing invasion Destructive invasion -No desmoplasia or -Complex growth pattern destructive invasion -Angulated infiltrative glands or single cells -Desmoplasia -Tumor cells floating in mucin WHO 2010 Davison, Mod Pathol 2014 Carr, AJSP 2016 Complex growth pattern Complex growth pattern Angulated infiltrative glands, desmoplasia Tumor cells in extracellular mucin Few floating cells common in LAMN Few floating cells common in LAMN Implications of diagnosis LAMN Mucinous adenocarcinoma LN metastasis Rare Common Hematogenous Rare Can occur spread -
Te2, Part Iii
TERMINOLOGIA EMBRYOLOGICA Second Edition International Embryological Terminology FIPAT The Federative International Programme for Anatomical Terminology A programme of the International Federation of Associations of Anatomists (IFAA) TE2, PART III Contents Caput V: Organogenesis Chapter 5: Organogenesis (continued) Systema respiratorium Respiratory system Systema urinarium Urinary system Systemata genitalia Genital systems Coeloma Coelom Glandulae endocrinae Endocrine glands Systema cardiovasculare Cardiovascular system Systema lymphoideum Lymphoid system Bibliographic Reference Citation: FIPAT. Terminologia Embryologica. 2nd ed. FIPAT.library.dal.ca. Federative International Programme for Anatomical Terminology, February 2017 Published pending approval by the General Assembly at the next Congress of IFAA (2019) Creative Commons License: The publication of Terminologia Embryologica is under a Creative Commons Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) license The individual terms in this terminology are within the public domain. Statements about terms being part of this international standard terminology should use the above bibliographic reference to cite this terminology. The unaltered PDF files of this terminology may be freely copied and distributed by users. IFAA member societies are authorized to publish translations of this terminology. Authors of other works that might be considered derivative should write to the Chair of FIPAT for permission to publish a derivative work. Caput V: ORGANOGENESIS Chapter 5: ORGANOGENESIS -
Current Findings on Gut Microbiota Mediated Immune Modulation Against Viral Diseases in Chicken
viruses Review Current Findings on Gut Microbiota Mediated Immune Modulation against Viral Diseases in Chicken 1, 1, 2 1 Muhammad Abaidullah y, Shuwei Peng y, Muhammad Kamran , Xu Song and Zhongqiong Yin 1,* 1 Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China 2 Queensland Alliance for Agriculture and food Innovation, The University of Queensland, Brisbane 4072, Australia * Correspondence: [email protected] Those authors contribute equally to the work. y Received: 18 June 2019; Accepted: 19 July 2019; Published: 25 July 2019 Abstract: Chicken gastrointestinal tract is an important site of immune cell development that not only regulates gut microbiota but also maintains extra-intestinal immunity. Recent studies have emphasized the important roles of gut microbiota in shaping immunity against viral diseases in chicken. Microbial diversity and its integrity are the key elements for deriving immunity against invading viral pathogens. Commensal bacteria provide protection against pathogens through direct competition and by the production of antibodies and activation of different cytokines to modulate innate and adaptive immune responses. There are few economically important viral diseases of chicken that perturb the intestinal microbiota diversity. Disruption of microbial homeostasis (dysbiosis) associates with a variety of pathological states, which facilitate the establishment of acute viral infections in chickens. In this review, we summarize the calibrated interactions among the microbiota mediated immune modulation through the production of different interferons (IFNs) ILs, and virus-specific IgA and IgG, and their impact on the severity of viral infections in chickens. Here, it also shows that acute viral infection diminishes commensal bacteria such as Lactobacillus, Bifidobacterium, Firmicutes, and Blautia spp. -
Comparative Anatomy of the Lower Respiratory Tract of the Gray Short-Tailed Opossum (Monodelphis Domestica) and North American Opossum (Didelphis Virginiana)
University of Tennessee, Knoxville TRACE: Tennessee Research and Creative Exchange Doctoral Dissertations Graduate School 12-2001 Comparative Anatomy of the Lower Respiratory Tract of the Gray Short-tailed Opossum (Monodelphis domestica) and North American Opossum (Didelphis virginiana) Lee Anne Cope University of Tennessee - Knoxville Follow this and additional works at: https://trace.tennessee.edu/utk_graddiss Part of the Animal Sciences Commons Recommended Citation Cope, Lee Anne, "Comparative Anatomy of the Lower Respiratory Tract of the Gray Short-tailed Opossum (Monodelphis domestica) and North American Opossum (Didelphis virginiana). " PhD diss., University of Tennessee, 2001. https://trace.tennessee.edu/utk_graddiss/2046 This Dissertation is brought to you for free and open access by the Graduate School at TRACE: Tennessee Research and Creative Exchange. It has been accepted for inclusion in Doctoral Dissertations by an authorized administrator of TRACE: Tennessee Research and Creative Exchange. For more information, please contact [email protected]. To the Graduate Council: I am submitting herewith a dissertation written by Lee Anne Cope entitled "Comparative Anatomy of the Lower Respiratory Tract of the Gray Short-tailed Opossum (Monodelphis domestica) and North American Opossum (Didelphis virginiana)." I have examined the final electronic copy of this dissertation for form and content and recommend that it be accepted in partial fulfillment of the equirr ements for the degree of Doctor of Philosophy, with a major in Animal Science. Robert W. Henry, Major Professor We have read this dissertation and recommend its acceptance: Dr. R.B. Reed, Dr. C. Mendis-Handagama, Dr. J. Schumacher, Dr. S.E. Orosz Accepted for the Council: Carolyn R. -
The Evolution of Nasal Immune Systems in Vertebrates
Molecular Immunology 69 (2016) 131–138 Contents lists available at ScienceDirect Molecular Immunology j ournal homepage: www.elsevier.com/locate/molimm The evolution of nasal immune systems in vertebrates ∗ Ali Sepahi, Irene Salinas Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, USA a r t i c l e i n f o a b s t r a c t Article history: The olfactory organs of vertebrates are not only extraordinary chemosensory organs but also a powerful Received 15 July 2015 defense system against infection. Nasopharynx-associated lymphoid tissue (NALT) has been traditionally Received in revised form 5 September 2015 considered as the first line of defense against inhaled antigens in birds and mammals. Novel work in Accepted 6 September 2015 early vertebrates such as teleost fish has expanded our view of nasal immune systems, now recognized Available online 19 September 2015 to fight both water-borne and air-borne pathogens reaching the olfactory epithelium. Like other mucosa- associated lymphoid tissues (MALT), NALT of birds and mammals is composed of organized lymphoid Keywords: tissue (O-NALT) (i.e., tonsils) as well as a diffuse network of immune cells, known as diffuse NALT (D- Evolution NALT). In teleosts, only D-NALT is present and shares most of the canonical features of other teleost Nasal immunity NALT MALT. This review focuses on the evolution of NALT in vertebrates with an emphasis on the most recent Mucosal immunity findings in teleosts and lungfish. Whereas teleost are currently the most ancient group where NALT has Vertebrates been found, lungfish appear to be the earliest group to have evolved primitive O-NALT structures. -
Avian Crop Function–A Review
Ann. Anim. Sci., Vol. 16, No. 3 (2016) 653–678 DOI: 10.1515/aoas-2016-0032 AVIAN CROP function – A REVIEW* * Bartosz Kierończyk1, Mateusz Rawski1, Jakub Długosz1, Sylwester Świątkiewicz2, Damian Józefiak1♦ 1Department of Animal Nutrition and Feed Management, Poznań University of Life Sciences, Wołyńska 33, 60-637 Poznań, Poland 2Department of Animal Nutrition and Feed Science, National Research Institute of Animal Production, 32-083 Balice n. Kraków, Poland ♦Corresponding author: [email protected] Abstract The aim of this review is to present and discuss the anatomy and physiology of crop in different avian species. The avian crop (ingluvies) present in most omnivorous and herbivorous bird spe- cies, plays a major role in feed storage and moistening, as well as functional barrier for pathogens through decreasing pH value by microbial fermentation. Moreover, recent data suggest that this gastrointestinal tract segment may play an important role in the regulation of the innate immune system of birds. In some avian species ingluvies secretes “crop milk” which provides high nutri- ents and energy content for nestlings growth. The crop has a crucial role in enhancing exogenous enzymes efficiency (for instance phytase and microbial amylase,β -glucanase), as well as the activ- ity of bacteriocins. Thus, ingluvies may have a significant impact on bird performance and health status during all stages of rearing. Efficient use of the crop in case of digesta retention time is es- sential for birds’ growth performance. Thus, a functionality of the crop is dependent on a number of factors, including age, dietary factors, infections as well as flock management. -
Innate Immune System of Mallards (Anas Platyrhynchos)
Anu Helin Linnaeus University Dissertations No 376/2020 Anu Helin Eco-immunological studies of innate immunity in Mallards immunity innate of studies Eco-immunological List of papers Eco-immunological studies of innate I. Chapman, J.R., Hellgren, O., Helin, A.S., Kraus, R.H.S., Cromie, R.L., immunity in Mallards (ANAS PLATYRHYNCHOS) Waldenström, J. (2016). The evolution of innate immune genes: purifying and balancing selection on β-defensins in waterfowl. Molecular Biology and Evolution. 33(12): 3075-3087. doi:10.1093/molbev/msw167 II. Helin, A.S., Chapman, J.R., Tolf, C., Andersson, H.S., Waldenström, J. From genes to function: variation in antimicrobial activity of avian β-defensin peptides from mallards. Manuscript III. Helin, A.S., Chapman, J.R., Tolf, C., Aarts, L., Bususu, I., Rosengren, K.J., Andersson, H.S., Waldenström, J. Relation between structure and function of three AvBD3b variants from mallard (Anas platyrhynchos). Manuscript I V. Chapman, J.R., Helin, A.S., Wille, M., Atterby, C., Järhult, J., Fridlund, J.S., Waldenström, J. (2016). A panel of Stably Expressed Reference genes for Real-Time qPCR Gene Expression Studies of Mallards (Anas platyrhynchos). PLoS One. 11(2): e0149454. doi:10.1371/journal. pone.0149454 V. Helin, A.S., Wille, M., Atterby, C., Järhult, J., Waldenström, J., Chapman, J.R. (2018). A rapid and transient innate immune response to avian influenza infection in mallards (Anas platyrhynchos). Molecular Immunology. 95: 64-72. doi:10.1016/j.molimm.2018.01.012 (A VI. Helin, A.S., Wille, M., Atterby, C., Järhult, J., Waldenström, J., Chapman, N A S J.R. -
1 Avian Immune Responses to Ectoparasites
Avian immune responses to ectoparasites: a serological survey of ectoparasite-specific antibodies in birds in western Nebraska Carol Fassbinder-Orth Abstract Birds serve as reservoirs for at least 10 arthropod borne viruses of wildlife and human concern (e.g. West Nile virus, Western Equine Encephalitis) and greater knowledge of the immune system dynamics of avian hosts and their disease vectors will have obvious economic benefits to agricultural, wildlife and human health interests. The more we begin to understand the host-vector- pathogen interactions that contribute to the emergence and transmission of arthropod borne diseases, we can better predict where outbreaks might occur and whose health and economic interests will be affected. Arthropod vectors (ectoparasites) exert strong direct selection pressures on their avian hosts by decreasing nestling survival, reducing future reproductive events and host lifespan. Levels of ectoparasites are known to vary widely across species with different life history strategies, and also across different life history stages of the same species. For example, colonial nesting birds (e.g. swallows and martins) have been shown to have enhanced levels of ectoparasites compared to non-colonial birds (e.g. sparrows) and nestlings are known to be highly susceptible to ectoparasites in multiple avian species. However, no studies have been performed that have investigated how immune responses to arthropod disease vectors variy across avian species with different life history characteristics (i.e. native vs. invasive), or the role that arthropod salivary proteins play in avian arbovirus disease ecology. The specific objectives of this proposal are aimed at quantifying the immune responses of free-living cliff swallows and house sparrows to the salivary proteins of an ecologically relevant ectoparasite, the swallow bug. -
Nomina Histologica Veterinaria, First Edition
NOMINA HISTOLOGICA VETERINARIA Submitted by the International Committee on Veterinary Histological Nomenclature (ICVHN) to the World Association of Veterinary Anatomists Published on the website of the World Association of Veterinary Anatomists www.wava-amav.org 2017 CONTENTS Introduction i Principles of term construction in N.H.V. iii Cytologia – Cytology 1 Textus epithelialis – Epithelial tissue 10 Textus connectivus – Connective tissue 13 Sanguis et Lympha – Blood and Lymph 17 Textus muscularis – Muscle tissue 19 Textus nervosus – Nerve tissue 20 Splanchnologia – Viscera 23 Systema digestorium – Digestive system 24 Systema respiratorium – Respiratory system 32 Systema urinarium – Urinary system 35 Organa genitalia masculina – Male genital system 38 Organa genitalia feminina – Female genital system 42 Systema endocrinum – Endocrine system 45 Systema cardiovasculare et lymphaticum [Angiologia] – Cardiovascular and lymphatic system 47 Systema nervosum – Nervous system 52 Receptores sensorii et Organa sensuum – Sensory receptors and Sense organs 58 Integumentum – Integument 64 INTRODUCTION The preparations leading to the publication of the present first edition of the Nomina Histologica Veterinaria has a long history spanning more than 50 years. Under the auspices of the World Association of Veterinary Anatomists (W.A.V.A.), the International Committee on Veterinary Anatomical Nomenclature (I.C.V.A.N.) appointed in Giessen, 1965, a Subcommittee on Histology and Embryology which started a working relation with the Subcommittee on Histology of the former International Anatomical Nomenclature Committee. In Mexico City, 1971, this Subcommittee presented a document entitled Nomina Histologica Veterinaria: A Working Draft as a basis for the continued work of the newly-appointed Subcommittee on Histological Nomenclature. This resulted in the editing of the Nomina Histologica Veterinaria: A Working Draft II (Toulouse, 1974), followed by preparations for publication of a Nomina Histologica Veterinaria. -
New Developments in Goblet Cell Mucus Secretion and Function
REVIEW nature publishing group New developments in goblet cell mucus secretion and function GMH Birchenough1, MEV Johansson1, JK Gustafsson1, JH Bergstro¨m1 and GC Hansson1 Goblet cells and their main secretory product, mucus, have long been poorly appreciated; however, recent discoveries have changed this and placed these cells at the center stage of our understanding of mucosal biology and the immunology of the intestinal tract. The mucus system differs substantially between the small and large intestine, although it is built around MUC2 mucin polymers in both cases. Furthermore, that goblet cells and the regulation of their secretion also differ between these two parts of the intestine is of fundamental importance for a better understanding of mucosal immunology. There are several types of goblet cell that can be delineated based on their location and function. The surface colonic goblet cells secrete continuously to maintain the inner mucus layer, whereas goblet cells of the colonic and small intestinal crypts secrete upon stimulation, for example, after endocytosis or in response to acetyl choline. However, despite much progress in recent years, our understanding of goblet cell function and regulation is still in its infancy. THE INTESTINE system of mucus covering the epithelium. There is a The gastrointestinal tract is a remarkable organ. Not only can it two-layered mucus system in the stomach and colon and a digest most of our food into small components, but it is also single-layered mucus in the small intestine.5 The mucus layers filled with kilograms of microbes that live in stable equilibrium in these three regions perform their protective function using with us and our immune system. -
Histopathology of Barrett's Esophagus and Early-Stage
Review Histopathology of Barrett’s Esophagus and Early-Stage Esophageal Adenocarcinoma: An Updated Review Feng Yin, David Hernandez Gonzalo, Jinping Lai and Xiuli Liu * Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA; fengyin@ufl.edu (F.Y.); hernand3@ufl.edu (D.H.G.); jinpinglai@ufl.edu (J.L.) * Correspondence: xiuliliu@ufl.edu; Tel.: +1-352-627-9257; Fax: +1-352-627-9142 Received: 24 October 2018; Accepted: 22 November 2018; Published: 27 November 2018 Abstract: Esophageal adenocarcinoma carries a very poor prognosis. For this reason, it is critical to have cost-effective surveillance and prevention strategies and early and accurate diagnosis, as well as evidence-based treatment guidelines. Barrett’s esophagus is the most important precursor lesion for esophageal adenocarcinoma, which follows a defined metaplasia–dysplasia–carcinoma sequence. Accurate recognition of dysplasia in Barrett’s esophagus is crucial due to its pivotal prognostic value. For early-stage esophageal adenocarcinoma, depth of submucosal invasion is a key prognostic factor. Our systematic review of all published data demonstrates a “rule of doubling” for the frequency of lymph node metastases: tumor invasion into each progressively deeper third of submucosal layer corresponds with a twofold increase in the risk of nodal metastases (9.9% in the superficial third of submucosa (sm1) group, 22.0% in the middle third of submucosa (sm2) group, and 40.7% in deep third of submucosa (sm3) group). Other important risk factors include lymphovascular invasion, tumor differentiation, and the recently reported tumor budding. In this review, we provide a concise update on the histopathological features, ancillary studies, molecular signatures, and surveillance/management guidelines along the natural history from Barrett’s esophagus to early stage invasive adenocarcinoma for practicing pathologists. -
Mucosal Immunity
Mucosal Immunity Lloyd Mayer, MD ABSTRACT. Food allergy is the manifestation of an antibody, secretory immunoglobulin A (sIgA), which abnormal immune response to antigen delivered by the is highly suited for the hostile environment of the gut oral route. Normal mucosal immune responses are gen- (Fig 1). All of these in concert eventuate in the im- erally associated with suppression of immunity. A nor- munosuppressed tone of the gastrointestinal (GI) mal mucosal immune response relies heavily on a num- tract. Defects in any individual component may pre- ber of factors: strong physical barriers, luminal digestion dispose to intestinal inflammation or food allergy. of potential antigens, selective antigen sampling sites, and unique T-cell subpopulations that effect suppres- sion. In the newborn, several of these pathways are not MUCOSAL BARRIER matured, allowing for sensitization rather than suppres- The mucosal barrier is a complex structure com- sion. With age, the mucosa associated lymphoid tissue posed of both cellular and noncellular components.5 matures, and in most individuals this allows for genera- Probably the most significant barrier to antigen entry tion of the normal suppressed tone of the mucosa asso- into the mucosa-associated lymphoid tissue (MALT) ciated lymphoid tissue. As a consequence, food allergies are largely outgrown. This article deals with the normal is the presence of enzymes starting in the mouth and facets of mucosal immune responses and postulates how extending down to the stomach, small bowel, and the different processes may be defective in food-allergic colon. Proteolytic enzymes in the stomach (pepsin, patients. Pediatrics 2003;111:1595–1600; gastrointestinal papain) and small bowel (trypsin, chymotrypsin, allergy, food allergy, food hypersensitivity, oral tolerance, pancreatic proteases) perform a function that they mucosal immunology.