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Mucosal Immunity Mucosal Immunity Lloyd Mayer, MD ABSTRACT. Food allergy is the manifestation of an antibody, secretory immunoglobulin A (sIgA), which abnormal immune response to antigen delivered by the is highly suited for the hostile environment of the gut oral route. Normal mucosal immune responses are gen- (Fig 1). All of these in concert eventuate in the im- erally associated with suppression of immunity. A nor- munosuppressed tone of the gastrointestinal (GI) mal mucosal immune response relies heavily on a num- tract. Defects in any individual component may pre- ber of factors: strong physical barriers, luminal digestion dispose to intestinal inflammation or food allergy. of potential antigens, selective antigen sampling sites, and unique T-cell subpopulations that effect suppres- sion. In the newborn, several of these pathways are not MUCOSAL BARRIER matured, allowing for sensitization rather than suppres- The mucosal barrier is a complex structure com- sion. With age, the mucosa associated lymphoid tissue posed of both cellular and noncellular components.5 matures, and in most individuals this allows for genera- Probably the most significant barrier to antigen entry tion of the normal suppressed tone of the mucosa asso- into the mucosa-associated lymphoid tissue (MALT) ciated lymphoid tissue. As a consequence, food allergies are largely outgrown. This article deals with the normal is the presence of enzymes starting in the mouth and facets of mucosal immune responses and postulates how extending down to the stomach, small bowel, and the different processes may be defective in food-allergic colon. Proteolytic enzymes in the stomach (pepsin, patients. Pediatrics 2003;111:1595–1600; gastrointestinal papain) and small bowel (trypsin, chymotrypsin, allergy, food allergy, food hypersensitivity, oral tolerance, pancreatic proteases) perform a function that they mucosal immunology. were designed to perform, digestion. Breakdown of large polypeptides into small dipeptides and tripep- ABBREVIATIONS. sIgA, secretory immunoglobulin A; GI, gastro- tides accomplishes 2 tasks: it allows for the process of intestinal; MALT, mucosa-associated lymphoid tissue; Ag, anti- digestion and absorption of nutrients to occur, and it gen; IgE, immunoglobulin E; IEC, intestinal epithelial cell; SC, renders potentially immunogenic proteins nonim- secretory component; IgM, immunoglobulin M. munogenic (peptides Ͻ8–10 amino acids in length are poor immunogens). Couple the effects of these he mucosal immune system is recognized by proteases with the emulsifying effect of bile salts and differences from its systemic counterpart. In the effects of enzymes that break down carbohy- Tmany ways, it is the opposite of what might be drates and you have a potent system to alter antigen viewed as systemic immunity, suppression rather (Ag) exposure. Add on extremes of pH in the stom- than active immune responses. It is thought that this ach and proximal small bowel and bacterial products difference reflects the distinct challenges of each sys- in the colon and it seems amazing that immune tem: the mucosa directly exposed to the external responses to oral Ag can occur at all. Fortunately for environment and taxed with antigenic loads consist- the host, they do, and many of these responses pro- ing of commensal bacteria, dietary antigens, and vi- vide protection against potential pathogens. The de- ruses at far greater quantities on a daily basis than cision to respond or suppress a response may relate the systemic immune system sees in a lifetime. It is to the pathway used by the Ag to gain access to the recognized that the mucosal immune response is also host. Invasive pathogens (breaking the barrier) elicit distinct, largely focused on suppressing immunity aggressive responses, whereas luminal colonizers re- rather than promoting it.1–4 The mucosal immune quire a more tolerant response. system uses a number of mechanisms to protect the A key component of the barrier is the products of host against an aggressive immune response to lu- the mucin genes. Mucin glycoproteins line the sur- minal constituents. face epithelium from the nasal cavity/oropharynx to These include a strong physical barrier; the pres- the rectum.6–10 Mucus-producing goblet cells contin- ence of luminal enzymes that alter the nature of the uously produce a thick barrier covering adjacent ep- antigen itself; the presence of specific regulatory T ithelium. Particles, bacteria, and viruses become cells in both the organized and disorganized lym- trapped in the mucus layer and are expelled by the phoid tissue of the gut; and the production of an peristaltic process of the gut. This barrier prevents potential pathogens and antigens from gaining ac- From the Department of Medicine and Immunobiology, Mount Sinai School cess to the underlying epithelium, a process called of Medicine, New York, New York. nonimmune exclusion. Mucins also serve as a reser- Received for publication Sep 11, 2002; accepted Oct 30, 2002. voir for sIgA. This antibody traverses the epithelium Reprint requests to (L.M.) Mount Sinai Medical Center, 1425 Madison Ave, New York, NY 10029. E-mail: [email protected] and is secreted into the lumen. PEDIATRICS (ISSN 0031 4005). Copyright © 2003 by the American Acad- sIgA present in the mucus layer binds bacteria/ emy of Pediatrics. viruses and prevents epithelial attachment. An asso- Downloaded from www.aappublications.org/news by guestPEDIATRICS on October 2, Vol. 2021 111 No. 6 June 2003 1595 Fig 1. Innate and adaptive immunity in the gut. ciated family of factors, called trefoil factors, helps elicit an immunosuppressive response, might result strengthen the barrier and promote restoration of the in antigen priming. In an individual who is geneti- barrier if any defects occur. In the absence of mucin cally predisposed to an allergic response (immuno- gene products or trefoil factors, the host is more globulin E [IgE]), a food-induced allergic process susceptible to inflammation and less capable of re- may ensue. pairing breeches in the barrier.11,12 Whether such The epithelial cell itself may play a role in this defects exist in food allergic patients is not known process as well. Several laboratories have shown that but would be worth studying. intestinal epithelial cells (IECs) express a number of Several investigators have demonstrated that the cell surface molecules (restriction elements) involved neonate (rat and mouse) has increased intestinal per- in T cell responses. Furthermore, studies have shown meability, allowing for passage of dietary and possi- that IECs can function as nonprofessional antigen- bly bacterial antigens into the underlying lymphoid- presenting cells.20–22 A classical Ag-presenting cell rich lamina propria of the GI tract.13–17 This would possesses 3 major characteristics: 1) it expresses bypass mechanisms involved in tolerance induction products of the class II major histocompatibility com- and could promote some form of active immune plex (eg, HLA-DR), 2) it takes up antigens by either response. Along these lines, it has been well-docu- receptor-mediated or fluid-phase endocytosis, and 3) mented that oral tolerance cannot be induced in the antigens are processed within endosomes and neonate. The mechanism(s) underlying this observa- loaded onto class II molecules whereupon these are tion has not been elucidated, although the onset of expressed on the cell surface, where the complex can tolerance seems to correlate with “gut closure.” interact with specific T-cell receptors. Epithelial cells However, immaturity of the MALT is also a factor, may act as nonprofessional Ag-presenting cells by and studies to characterize these processes have not sampling partially processed Ags from the lumen been performed. and presenting these, in the context of unique restric- tion elements (Fig 2), to T cells in the lamina propria. INTESTINAL EPITHELIAL CELLS In the normal state, this interaction seems to result in The next layer of the barrier is the epithelial cell. the selective activation of regulatory CD8ϩ T cells. In Joined together by tight junctions apically and ba- certain disease states (eg, inflammatory bowel dis- sally, the membrane and paracellular spaces are gen- ease), the activation of such cells is defective, possi- erally impervious to large macromolecules. In fact, bly explaining the persistent inflammation.23 In food tight junctions prevent even the passage of di- and allergy, newer data suggest that additional pathways tripeptides. Only ions are capable of passing may be involved. In work by Berin et al,24,25 it has through. In inflamed states, as well as in the perinatal been shown that allergens exhibit facilitated trans- period, the tight junctions are less “tight,” allowing port across the epithelium with delivery to Fc⑀R for the passage of macromolecules into the underly- bearing mucosal mast cells (Fig 3). ing lamina propria. It is during such events that Cross-linking IgE results in mast-cell degranula- response to dietary Ags or luminal microorganisms tion and fluid and electrolyte secretion by the epithe- can occur. There has been a suggestion that intestinal lial cells (IEC). This process, demonstrated in a rat permeability might be abnormal in food-allergic in- model of systemic allergen exposure (ovalbumin in dividuals.18,19 Direct consistent reliable measure- pertussis toxin), depends on interleukin-4-induced ments have not been reported, however, so this ques- CD23 (low-affinity Fc⑀R) expression on epithelial tion remains unanswered. In the
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