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Scientific Evaluation and Standardization of the Ayurvedic Compound Formulation Yavānyādi Cūra

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Scientific Evaluation and Standardization of the Ayurvedic Compound Formulation Yavānyādi Cūra Indian Journal of Traditional Knowledge Vol. 14(4), October 2015, pp. 544-549 Scientific evaluation and standardization of the Ayurvedic compound formulation Yavānyādi cūrṇa AK Tiwari *, N Dwivedi & MK Tripathi Ayurveda Sadan, JRD Tata Foundation for Research in Ayurveda & Yoga Sciences, Arogyadham, Deendayal Research Institute, Chitrakoot, Satna, 485334, Madhya Pradesh, India E-mail: [email protected] Received 30 September 2014, revised 17October 2014 The present study deals with the scientific evaluation and standardization of the Ayurvedic compound formulation Yavānyādi cūrṇa following quality control procedures both for the raw materials and the finished product. The obtained values (ranges of physico-chemical parameters) can be adapted to day down new pharmacopoeial standards to be followed for traditional preparation of Yavānyādi cūrṇa with batch to batch consistency. The phytochemical constituents found to present in the raw material used for the preparation of Yavānyādi cūrṇa facilitate the desirable therapeutic efficacy of the medicinal formulations a whole in elements and also could help in knowing the underlying mechanism of pharmacological action. Keywords: Ayurvedic formulation, Yavānyādi cūrṇa, Drug standardization IPC Int. Cl.8: A61B 5/117, G06K 9/00, A61K, A01D 20/00 Ayurveda is an indigenous Indian system of medicine quality and batch to batch consistency. Hence, there is that is mainly plant-based and has gained worldwide a need for standardization of Ayurvedic curna attention due to safety and efficacy. However, due to following scientific parameters including descriptive lack of proper quality control methods there are taxonomic identification of raw drugs, organoleptic variations in the same product obtained from different characters, phytochemical analysis, chromatographic sources. Standardization is important for insuring of pattern and microbial screening. good quality products as standardized drugs of well The work was undertaken is the trust as part of a defined consistent quality are needed for reliable program of testing and validation of traditional practices beneficial therapeutic uses. Thus, there is an urgent of using the Ayurvedic medicine. Yavānyādi cūrṇa9 is need to develop parameters for quality control which traditionally used for treatment of Atīsarta (diarrhoea), are cost effective and can be easily adopted by the Ksaya (pthisis), Gulma (abdominai lump), Udara manufactures. Efforts are being made in this area that (disesses of abdomen), Kãsa (cough), Agnimāndya have led to the development of analytical protocols (digestive impairment), Aŕsā (piles), Pīnasa (chronic both for single herbal drugs as well as for compound rhinitis) and Arucī (Anorexia). In this connection, herbal formulations1-8 that can be used as valuable standardization of Yavānyādi cūrṇa becomes imperative. analytical tools in the routine standardization of The current work deals with detailed standardization Ayurvedic drugs and formulations. guidelines involving Good Manufacturing (GMP) Yavānyādi cūrṇa is an Ayurvedic polyherbal prescribed for preparation of Ayurvedic medicines. formulation has been use in asthama, mal absorption Standardization guidelines to be followed10 for herbals syndrome9, etc. The preparation of Yavānyādi cūrṇa is products provided by World Health Organization based on traditional methods is accordance with the (WHO)11, and Ayurvedic pharmacopoeia of India have procedures given in classical texts like Ayurvedic been considered. In the standardization procedures formulary of India I. Due to lack of modern followed in the work, certain in process tests have also pharmacopoeia standards laid down and followed for been developed and performed. processing of Yavānyādi cūrṇa, the medicine prepared Methodology using traditional methods may not have the desired Preparation of the curna All the ingredients were used of Pharmacopoeial *Corresponding author quality. These were washed, dried and ground TIWARI et al.: SCIENTIFIC EVALUATIOPN OF YAVĀNYĀDI CŪRṆA 545 individually passed through 180 µm separately then Physico-chemical parameters weighed separately, mixed in specified ratio and Organoleptic characters, particle size and physico- 10, 14-15 passed through 355 µm to obtain a homogenous chemical analysis of all the samples were blend. It was stored in an airtight container to protect carried out. Quantitative analysis for total ash, acid from light and moisture. Three different samples of insoluble ash, water soluble ash, extractive values in Yavānyādi cūrṇa were studied. Each sample of water soluble and alcohol soluble extractive, loss on Yavānyādi cūrṇa was formulated using 21 drying at 105°C, volatile oil, total sugar, reducing ingredients9, i.e. Yavāni (Trachyspermu ammi (L.) sugar and pH of filtrate of 10% w/v aqueous solution ī ū were checked in triplicate according to the prescribed Sprague. fruit), Pippal m la (Piper longum L. root), 16 Tvak (Cinnamomum zeylanicum Blume. stem bark), Standard methods in Indian Pharmacopoeia . Elā (Elettaria cardamomum Maton, seed), Patra High pressure thin layer chromatography (HPTLC) (Cinnamomum tamala Nees & Eberm, leaf), For HPTLC11, 14-15, 17, 5 gm of coarsely powdered Nāgakesara (Mesua ferrea L. stamen), Nāgara drug in 250 ml stoppered conical flask and extracted (Zingiber officinale Rose. Rhizome), Marica (Piper with 100 ml ethanol for 24 hrs by maceration nigrum L. fruit), Agni (Plumbago zey lanica L. root), technique with occasional shaking. The extract was Jala (Coleus vettiveroides K.C. Jacos. root), Ajājī extracted and volume was raised up to 100ml in a (Cuminum cyminum L. fruit), Dhānya (Corindrum volumetric flask. Twenty five ml extract was taken sativum L. fruit), Sauvarcala lavaṇa (black salt), from the above stock solution and concentrated on a Vṛkṣāmla (Garcinia indica Choisy. fruit pulp), water bath to similarly, methanol extract was prepared Dhātakī (Woodfordia fruticosa Kurz. flower), Krsnạ̄ ̣ ̣ for 3 batches of Yavānyādi cūrṇa. TLC of extracts of (Piper longum L. fruit), Bilva (Aegle marmelos Coor, all the samples was carried out on silica gel 60 F254 unripe fruit pulp), Dāḍima (Punica granatum L. dried pre-coated plates (0.2 mm thickness; from Merck seed), Dīpyaka (Apium graveolens L. fruit), Sitã India Limited). An Applicator from Camag Linomat-5 (sugar) and Kapittha (Feronia limonia (L.) Swingle, (Camag Switzerland: 140443) was used for band unripe fruit pulp) 12-13 prepared as per AFI9 (Table 1). application and photo documentation unit (Camag Table 1Ingredients of Yavānyādi cūrṇa S. no. Sanskrit Name Botanical name Parts used Portion 1. Yavāni Trachyspermu ammi (L.) Sprague Fruit 1 Part 2. Pippalīmūla (Pippalī ) Piper longum L. Root 1 Part 3. Tvak Cinnamomum zeylanicum Blume Stem bark 1 Part 4. Elā (Suksmailā) Elettaria cardamomum Maton Seed 1 Part 5. Patra (Tvakpatra) Cinnamomum tamala Nees & Eberm Leaf 1 Part 6. Nāgakesara Mesua ferrea L. Stmn. 1 Part 7. Nāgara (Śunṭḥī) Zingiber officinale Rose. Rhizome 1 Part 8. Marica Piper nigrum L. Fruit 1 Part 9. Agni (Citraka) Plumbago zeylanica L. Root 1 Part 10. Jala (Hrībera) Coleus vettiveroides K.C. Jacos. Root 1 Part 11. Ajājī (Śveta jīraka) Cuminum cyminum L. Fruit 1 Part 12. Dhānya (Dhānyaka) Corindrum sativum L. Fruit 1 Part 13. Sauvarcala lavaṇa Black Salt - 3 Parts 14. Vṛkṣāmla Garcinia indica Choisy. Fruit Pulp 3 Parts 15. Dhātakī Woodfordia fruticosa Kurz. Flower 3 Parts 16. Krsṇā ̣ ̣ (Pippalī) Piper longum L. Fruit 3 Parts 17. Bilva Aegle marmelos Coor Unripe Fruit Pulp 3 Parts 18. Dāḍima Punica granatum L. Dried seed 3 Parts 19. Dīpyaka (Ajamodā) Apium graveolens L. Fruit 3 Parts 20. Sitã (Śarkarā) Sugar - 6 Parts 21. Kapittha Feronia limonia (L.) Swingle Unripe Fruit Pulp 8 Parts 546 INDIAN J TRADIT KNOWLE, VOL 4, NO. 4, OCTOBER 2015 Reprostar-3: 140604) was used for documentation of to get linear calibration (Merck). Pb and Cd were chromatographic fingerprints. The mobile phase used performed using graphite oven method, while As was Toluene: Ethyl acetate (7: 3). The plate was (Arsenic) were determined as hydride method and Hg developed over a distance of 9 cm in a saturated were determined using cold absorption method. development chamber (Twin trough chamber (10×10 c with SS lid, and visualized under visible light, Assay of sodium and potassium 254nm and 366nm. After spraying with anisaldehyde- Sodium (Na)18 and Potassium (K)18 were carried sulphuric acid is followed by heating at 105°C for 5 min. out using Flame photometer (ELCO-Model-CL361) and results are presented in per cent. Test for aflatoxin The 3 sample of Yavānyādi cūrṇa were also Results and discussion checked for mycotoxin, i.e., Aflatoxin with standard A brownish, fine powder with a spicy odour is with 14-15 markers B1, B2, G 1 & G2 . salty taste. The powder completely passes through 355 µm and not less than 50 % through 180 µm. Test for microbial limits Physico-chemical data was subjected to various Following tests were carry out as per standard 11,14 analytical parameters average value of loss and drying methods to determine the microbial load in 3 at 105°C 8.15.15% total ash content 5.13%, acid batches of Yavānyādi cūrṇa, a formulated compound insoluble ash 3.36%, alcohol soluble extractive drug powder of pharmaceutical substances 12.35%, water soluble extractive 40.20%, total sugar 7.45%, reducing sugar 0.58% volatile oil 1.5%, and 1. Enumeration of Staphylococcus aureus /gm pH 4.77 (Tables 2-3). 2. Enumeration of Salmonella sp./gm The TLC plate were examine under ultra violet 3. Enumeration of Pseudomonas
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