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(12) United States Patent (10) Patent No.: US 8,673,373 B2 Wycoff (45) Date of Patent: Mar

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(12) United States Patent (10) Patent No.: US 8,673,373 B2 Wycoff (45) Date of Patent: Mar USOO8673373B2 (12) United States Patent (10) Patent No.: US 8,673,373 B2 Wycoff (45) Date of Patent: Mar. 18, 2014 (54) HOMEOPATHICFORMULATIONS FOR FOREIGN PATENT DOCUMENTS TREATMENT OF HERPES VIRUS SYMPTOMS CN 1342491 4/2002 RU 2001402 10, 1993 (75) Inventor: Jeffrey Wycoff, Boulder, CO (US) OTHER PUBLICATIONS (73) Assignee: Paradigm, Inc., Longmont, CO (US) Ernst, is homeopathy a clinically valuable approach'? Trends in phar macological sciences 26911): 657-548, 2005.* (*) Notice: Subject to any disclaimer, the term of this Kleijnen et al. Clinical trials of homoeopathy, BMJ 302: 316-323, patent is extended or adjusted under 35 1991.* U.S.C. 154(b) by 0 days. Weissmann, Homeopathy: Holmes, Hogwarts, and the price of Wales, The FASEB Journal 20: 1755-1757, 2006.* (21) Appl. No.: 13/441,357 Ernst et al. Efficacy of homeopathic Arnica, Arch Surg 133: 1187 1190, 1998.* (22) Filed: Apr. 6, 2012 Ernst, A Systematic review of systematic reviews of homeopathy, Br J. Clin Pharmacol 54: 577-582, 2002.* (65) Prior Publication Data U.S. Appl. No. 12,658,993, filed Feb. 17, 2010. US 2012/O19597OA1 Aug. 2, 2012 U.S. Appl. No. 12/002,042, filed Dec. 14, 2007. Provisional U.S. Appl. No. 60/875,018, filed Dec. 15, 2006. Ernst, et al. Efficacy of Homeopathic Arnica. Arch Surg, vol. 133, pp. Related U.S. Application Data 1187-1190, 1998. (63) Continuation-in-part of application No. 127658,993, Ernst. A Systematic review of Systematic Reviews of Homeopathy. filed on Feb. 17, 2010, now Pat. No. 8,389,025, which BrJ Clin Pharmacol, vol. 54, pp. 577-582, 2002. is a continuation of application No. 12/002,042, filed Ernst. Is Homeopathy a Clinically Valuable Approach? Trends in on Dec. 14, 2007, now abandoned. Pharmacological Sciences, vol. 26, No. 11, Nov. 2005, pp. 547-548. Kleijnen et al. Clinical Trials of Homeopathy. BMJ, vol. 302, pp. (60) Provisional application No. 60/875,018, filed on Dec. 316-323, 1991. 15, 2006. McKeon. Herbal Management of Diabetic Leg Ulcers. Australian Journal of Medical Herbalism, vol. 6, No. 4, p. 99, 1994. (51) Int. Cl. Weissmann. Homeopathy: Holmes, Hogwarts, and the Prince of A6 IK36/00 (2006.01) Wales. The FACEB Journal, vol. 20, pp. 1755-1757, 2006. A6 IK33/22 (2006.01) A6 IK33/14 (2006.01) * cited by examiner (52) U.S. Cl. USPC ............................ 424/725; 424/658; 424/680 Primary Examiner — Qiuwen Mi (58) Field of Classification Search None (74) Attorney, Agent, or Firm — Craig R. Miles: CR Miles, See application file for complete search history. P.C. (56) References Cited (57) ABSTRACT U.S. PATENT DOCUMENTS Compositions and methods of preparing and using Such com 6,248,307 B1 6/2001 Borneman et al. positions to treat the symptoms of herpes virus. 2003,0003482 A1 1/2003 Halle et al. 2005/0129789 A1 6, 2005 Shirota 2005/0255166 A1 1 1/2005 Moloney 9 Claims, 7 Drawing Sheets U.S. Patent Mar. 18, 2014 Sheet 1 of 7 US 8,673,373 B2 MATERIAL POTENCY DESIGNATION Rhus toxicondendron between about 6X and about 200c HPUS Ranunculus bulbosus between about 3X and about 200c HPUS Phytolacca decandra between about 3X and about 200c HPUS Crab Apple between about 3X and about 200c HPUS Natrum muriaticum between about 3X and about 200c HPUS Borax between about 1X and about 200c HPUS FIGURE 1 U.S. Patent Mar. 18, 2014 Sheet 2 of 7 US 8,673,373 B2 MATERIAL POTENCY DESIGNATION Rhus toxicondendron 30x HPUS Ranunculus bulbosus 12x HPUS Phytolacca decandra 3X HPUS Crab Apple 5x HPUS Natrum muriaticum 30x HPUS Borax 1X HPUS FIGURE 2 U.S. Patent Mar. 18, 2014 Sheet 3 of 7 US 8,673,373 B2 MATERIAL POTENCY DESIGNATION Rhus toxicondendron 30X HPUS Ranunculus bulbosus 12X HPUS Phytolacca decandra 3X HPUS Crab Apple 1X HPUS Succinic acid 15 milligrams (mg) FIGURE 3 U.S. Patent Mar. 18, 2014 Sheet 4 of 7 US 8,673,373 B2 MATERIAL POTENCY DESIGNATION Rhus toxicondendron 30x HPUS Ranunculus bulbosus 12x HPUS Phytolaccca decandra 3X HPUS Crab Apple 1X HPUS Natrum muriaticum 30x HPUS Borax 1X HPUS FIGURE 4 U.S. Patent Mar. 18, 2014 Sheet 5 of 7 US 8,673,373 B2 MATERIAL POTENCY DESIGNATION Mezereum 12x HPUS Phytolacca decandra 12X HPUS Ranunculus bulbosus 12x HPUS Rhus toxicodendron 12X HPUS Sepia 30x HPUS Natrum Muriaticum 12X HPUS Clematix 12x HPUS Influenzinum 18X HPUS FIGURE 5 U.S. Patent Mar. 18, 2014 Sheet 6 of 7 US 8,673,373 B2 MATERIAL POTENCY DESIGNATION Mezereum 12X HPUS Phytolacca decandra 12X HPUS Ranunculus bulbosus 12X HPUS Rhus toxicodendron 12X HPUS Natrum Muriaticum 12X HPUS Clematix 12X HPUS Influenzinum 18X HPUS FIGURE 6 U.S. Patent Mar. 18, 2014 Sheet 7 Of 7 US 8,673,373 B2 MATERIAL POTENCY DESIGNATION Mezereum 12X HPUS Phytolacca decandra 12X HPUS Ranunculus bulbosus 12X HPUS Rhus toxicodendron 12X HPUS Sepia 30X HPUS Natrum Muriaticum 30x HPUS Clematis erecta 12x. HPUS Anatherum muricatum 12X HPUS Thuja occidentalis 12X HPUS FIGURE 7 US 8,673,373 B2 1. 2 HOMEOPATHC FORMULATIONS FOR reduce certain herpes virus symptoms and because the com TREATMENT OF HERPES VIRUS pliance rate can be high while the rate of side effects can be SYMPTOMS low. Despite advances in the art of herbal and homeopathic This United States Patent Application is a continuation-in remedies, there remains a need for additional compositions, part of U.S. patent application Ser. No. 127658,993, filed Feb. formulations, mixtures, potency dilution admixtures, or the 17, 2010, which is a continuation of U.S. patent application like and methods of preparing and using Such compositions, Ser. No. 12/002,042, filed Dec. 14, 2007, and claims the formulations, potency dilution admixtures, or the like to treat benefit of U.S. Provisional Patent Application No. 60/875, the symptoms of herpes virus which as compared to conven 018 filed Dec. 15, 2006, each hereby incorporated by refer 10 tional compositions, formulations, mixtures, potency dilution ence herein. admixtures provide alternative treatment with respect to the active ingredient or manner of delivery thereof or reduce to a I. BACKGROUND greater degree herpes virus symptoms. 15 Compositions and methods of preparing and using Such II. SUMMARY OF THE INVENTION compositions to treat the symptoms of herpes virus. The herpes simplex virus (HSV) is a virus that manifests Accordingly, a broad object of the invention can be to itself in two common viral infections, each marked by pain provide compositions, formulations, and potency dilution ful, watery blisters in the skin or mucous membranes (such as admixtures for the treatment of herpes virus symptoms. the mouth or lips) or on the genitals. The disease is conta Another broad object of the invention can be to provide gious, particularly during an outbreak, and is incurable with improved methods for preparing formulations, particularly present technology. An infection on the lips is commonly with respect to oral and topical dosage forms, useful in treat known as a “cold sore' or "fever blister'. These are some ing herpes virus symptoms. times confused with canker Sores or aphthous ulcers, which 25 Another broad object of the invention can be to provide have a similar appearance; these appear inside the mouth and methods of treating herpesvirus symptoms such as treatment are not caused by the herpes simplex virus. When asymptom preventing or providing a reduction in the frequency or sever atic, HSV lies dormant in the bodies of the nerve cells, rep ity of at least one Such symptom, or both the frequency or licating within the axons towards the skin during an outbreak. severity of at least one such symptom, or otherwise mitigating When the outbreak has passed, the virus dies back along the 30 Such symptoms. nerve until it is only present in the nerve body. The dormancy Another broad object of the invention can be to provide of the virus within the nerve bodies contributes to the diffi methods of preparing an oral dosage form for the treatment of culty of treatment. herpes virus symptoms. Such dosage forms may be prepared There is currently no cure for HSV. Treatment in the form by admixing or combining the requisite amounts of homeo of antiviral medications such as Acyclovir (trade name Zovi 35 pathic or herbal components, or both, together with any phar rax), Famciclovir, pancyclovir, Valacyclovir, or the like, maceutical excipients, and dividing the mixture into unit which reduce the duration of symptoms and accelerates heal doses containing an appropriate amount of the admixture or ing are available. Treatment typically begins at the first symp combination to treat herpes virus symptoms when adminis toms of an outbreak. tered to a person whether in Solid unit dosage or topical forms 40 Such as creams or liquids. Another option is the use of daily Suppressive therapy, in Another broad object of the invention can be to provide a which antivirals are taken every day over the course of years. method of treating herpesvirus symptoms by administering a Suppressive therapy may reduce frequency of symptoms and unit dose of the homeopathic components herein described recurrence of outbreaks. In addition, Suppressive therapy orally to a person as a treatment for herpes virus symptoms. reduces Subclinical shedding, lowering the risk of transmis 45 Another broad object of the invention can be to provide a sion through sexual contact or kissing. method of treating herpesvirus symptoms by administering a A Substantial problem with taking antiviral medications unit dose of the homeopathic components herein described can be side effects such as confusion, hallucinations, topically to a person as a treatment for herpes virus symp increased thirst, redness, blistering, peeling or loosening of tOmS.
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