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I in Un Torn Untuk Ta in an Atau Mana Na Anth IIN UN TORN UNTUKTAUS IN20170304388A1 AN ATAU MANA NA ANTH ( 19) United States (12 ) Patent Application Publication (10 ) Pub. No. : US 2017/ 0304388 A1 Chen et al. ( 43 ) Pub . Date: Oct. 26 , 2017 (54 ) NEW INDICATION OF CARDIOVASCULAR A61K 31/ 549 ( 2006 . 01 ) DRUGS FOR PREPARATION OF CANCER A61K 31 /505 (2006 .01 ) INHIBITION PHARMACEUTICAL A61K 31 / 404 ( 2006 .01 ) COMPOSITION A61K 31 / 366 ( 2006 .01 ) A61K 31 /341 ( 2006 . 01 ) (71 ) Applicant : LAUNX BIOMEDICAL CO ., LTD . , A61K 31 /216 ( 2006 .01 ) Kaohsiung ( TW ) A61K 31 / 197 (2006 .01 ) A61K 31 / 196 ( 2006 .01 ) ( 72 ) Inventors : Chiu -Hung Chen , Kaohsiung ( TW ) ; A61K 45 / 06 ( 2006 . 01 ) Show -Mei Chuang, Taichung ( TW ) ; A61K 31 / 138 ( 2006 . 01) Nai- Wan Hsiao , Taichung ( TW ) ; (52 ) U . S . CI. Ruei - Yue Liang , Taichung ( TW ) ; CPC .. .. .. .. A61K 38 /05 (2013 . 01 ) ; A61K 45 / 06 Xiao - Tong Tan , Taichung ( TW ) ( 2013 .01 ) ; A61K 31 / 7056 ( 2013 .01 ) ; A61K 31/ 55 (2013 .01 ) ; A61K 31 /549 ( 2013 .01 ) ; ( 73 ) Assignee : LAUNX BIOMEDICAL CO ., LTD ., A61K 31 /505 ( 2013 . 01 ) ; A61K 31/ 138 Kaohsiung ( TW ) (2013 . 01 ) ; A61K 31/ 366 ( 2013 . 01 ) ; A61K 31/ 341 ( 2013 .01 ) ; A61K 31/ 216 ( 2013 .01 ) ; (21 ) Appl. No. : 15 /521 , 536 A61K 31 / 197 (2013 . 01 ) ; A61K 31/ 196 ( 22 ) PCT Filed : Oct. 23 , 2015 ( 2013. 01 ) ; A61K 31/ 404 ( 2013. 01 ) ( 57 ) ABSTRACT ( 86 ) PCT No .: PCT/ CN2015 /092768 A method for treating a cancer includes administering to a $ 371 ( c ) ( 1 ) , subject in need thereof a pharmaceutical composition con ( 2 ) Date : Apr. 24 , 2017 taining a therapeutically effective amount of a cardiovascu lar drug or a pharmaceutical acceptable salt thereof. The Related U . S . Application Data cardiovascular drug is selected from the group consisting of peripheral vasodilator reaming enhancer, angiotensin con (60 ) Provisional application No . 62/ 068 , 298 , filed on Oct. verting agent inhibitor , hypotension and shock therapeutic 24 , 2014 . agent, diuretic , antiarrhythmic agent, antiarralciton drug , antihypertensive agent, anticoagulant thrombolytic agent, Publication Classification cardiac tonic , and intravenous (hemorrhoids ) therapeutic (51 ) Int. CI. agent . The cancer is selected from the group consisting of A61K 38 /05 ( 2006 . 01 ) lung cancer , intestinal cancer , colorectal cancer, prostate A61K 31 /7056 ( 2006 .01 ) cancer , liver cancer , bladder cancer , cervical cancer, breast A61K 31 /55 ( 2006 .01 ) cancer , and blood cancer . Patent Application Publication Oct 26 , 2017 US 2017 / 0304388 A1 -????? Huslepia? fantsDIDELIS poidang IslangeBullet DITHESLLAT perram TajMaan VÝ IMAGEseudoshladi REFIFIABLE . agromexcursioniO danossie 2903 Neza. BuBadgetPudpudingMenstagorious anlataudeep Oksiaze guid ": tamentosKontaktpara FIG.1 TUIM actoRECES k ::: : : : asdiendesigurkapsasen desu ???? es N ??? ???. omiseoguden MESEDapis HarTRADIO Festivalipigannoha noeper OMDETTEupu za Dummmmmmmmmmmmmmmmmmmmmmmmmmmmmm Namopdan 1901 410Pqmurje Xapuj HORO US 2017 /0304388 A1 Oct. 26 , 2017 NEW INDICATION OF CARDIOVASCULAR patient selection , trial dose and other issues . Even the drug DRUGS FOR PREPARATION OF CANCER has approved by the FDA and sales on the market , there still INHIBITION PHARMACEUTICAL possibly face the situation of the poor drug response in COMPOSITION patients . Furthermore , if the cancer patients happen the drug resistance , that would reduce the effectiveness of the drugs CROSS -REFERENCE TO RELATED and result in the medical treatment failure . Therefore , the APPLICATIONS new drug development is very difficult . [0001 ] This is a National Phase Application filed under 35 U . S . C . 371 as a national stage of PCT/ CN2015 / 092768 filed SUMMARY OF THE INVENTION Oct. 23 , 2015 , an application claiming the benefit under 35 [0009 ] To solve the above problems, the present invention USC 119 ( e ) to the following U . S . Provisional Applications provides a usage of existing cardiovascular drugs , which No. 62 / 068, 298 filed Oct. 24 , 2014 , the content of each of have passed clinical trials . which is hereby incorporated by reference in its entirety. 10010 ] The experiment results showed that the cardiovas cular drugs had no toxicity or only little toxicity to normal FIELD OF THE INVENTION cells . However , there are more studies need to be test to [0002 ] The present invention provides new clinical indi know that whether the cardiovascular drugs have selection cation of cardiovascular drugs , which were approved by between normal cells and cancer cells . Besides , not all the FDA . Particularly , the present invention demonstrates that cardiovascular drugs could inhibit the growth of cancer cells the cardiovascular drugs can effectively inhibit a variety of under same condition , there are still lots of problemsneed to be overcame. cancers . [0011 ] Term Definition [0012 ] The cardiovascular drugs can be classified to ten BACKGROUND OF THE INVENTION categories based on the features , includes : peripheral vaso [0003 ] Cancer is the most popular disease cause of death dilator reaming enhancer, angiotensin converting agent in the world . The cancer patients are gradually increase inhibitor , hypotension and shock therapeutic agent, diuretic , yearly , therefore the treatment method of the cancer has antiarrhythmic agent, antiarralciton drug , antihypertensive become an important issue . The medical treatments of agent, anticoagulant and thrombolytic agent, cardiac tonic , cancer can be classified as surgical treatment, radiation intravenous (hemorrhoids ) therapeutic agent. therapy , chemotherapy and target therapy. [0013 ] ( 1 ) Peripheral vasodilator reaming enhancer, which [0004 ] Generally , the cancer drug , whether chemotherapy can directly or indirectly effect on peripheral blood vessels drug or target therapy drug , is inhibit the cancer cells ' to increase blood flow , includes: Cilnidipine , Minoxidil , duplication and split to prevent the tumor growth and Prazosin HCl, Sildenafil citrate , Tadalafil (Cialis ) , Nic metastasis . In clinical treatment options , the combination of orandil ( Ikorel ) , Lacidipine ( Lacipil , Motens ) , Benidipine chemotherapies and several targeted therapies were selected ; hydrochloride , Cilazapril monohydrate ( Inhibace ) , Fosino try to eliminate cancer cells more effectively , by means of pril sodium (Monopril ) , Almotriptan malate (Axert ) , Milri different mechanisms. Furthermore , if the cancer patients none (Primacor ) , Avanafil , Lomerizine HC1, Histamine happen the drug resistance , that would reduce the effective Phosphate , Chromocarb and Pinacidil. ness of the drugs and result in the medical treatment failure . [0014 ] ( 2 ) Angiotensin converting agent inhibitor, which [0005 ] On the other side , treatment of cardiovascular is used to inhibit ACE activity and reduce the production of disease aims to prevent or delay the progression of the vasopressin II, so as to reduce the bradykinin hydrolysis , disease . Also , it aims to reduce the risk of developing lead to vasodilatation , blood volume, and decrease blood cardiovascular diseases. For example , some cardiovascular pressure , includes: Benazepril hydrochloride , Losartan drugs can treat high blood pressure , and other cardiovascular potassium , Perindopril Erbumine ( Aceon ), Irbesartan drugs can promote blood flow in patients with heart failure . ( Avapro ) , Candesartan ( Atacand ) , Olmesartan medoxomil [0006 ] Based on the many years ' experience of inventors , (Benicar ) , Enalaprilat dehydrate , Telmisartan (Micardis ) , the human cancer cells and normal cells often have different Ramipril ( Altace ) , Valsartan (Diovan ) , Enalapril maleate characteristics , the differences in patterns or mechanism (Vasotec ) , Candesartan cilexetil ( Atacand ) , Conivaptan HC1 variation might be seen as a foreign invader. The different ( Vaprisol) , Azilsartan Medoxomil ( TAK -491 ) and Eprosar cancel cells are located in different locations and the statuses tan Mesylate . of variations are related to the located environment. Thus, [0015 ) ( 3 ) Hypotension and shock therapeutic agent, the inventors are the first person to propose the use of which includes : L - Adrenaline ( Epinephrine ) , DL - Adrena antibiotic drugs to inhibit the cancer cell growth . line and Methoxamine HCl. [0007 ] In contrast , these cardiovascular drugs have been [0016 ) ( 4 ) Diuretic , which is used to increase the genera used for decades and are recognized by FDA long time ago . tion of urine and increase the excretion of human body These cardiovascular drugs already have been researched water , includes : Bumetanide , Furosemide ( Lasix ) , Metola and analyzed to know the mechanism on human body. zone ( Zaroxolyn ), Silodosin (Rapafio ) , Chlorothiazide , Therefore, the groundbreaking new application would be Trichlormethiazide ( Achletin ) , Torsemide (Demadex ) , time- saving and cost effective if these drugs applied in Hydrochlorothiazide , Indapamide (Lozol ) , Dichlorphena treating cancer. Besides , the treatment effect would be mide (Diclofenamide ) , Amiloride hydrochloride dehydrate , improved if these drugs are used to combine with other Solifenacin succinate , Methyclothiazide , Benzthiazide , treating method . Meticrane , Bendroflumethiazide and Potassium Canrenoate . [0008 ] Otherwise , the manufacturing of the drug is also a [0017 ] ( 5 ) Antiarrhythmic agent, which is used to inhibit big problem . When the drug starting the clinical trials, there abnormal heartbeat rhythm (arrhythmia ) , such as
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