hemistry C N E W S L E T T E R

Letter from the Chair Contents I am pleased to send greetings and to sociate Professor with tenure to Professor Letter from the Chair...... 1 highlight the activities of the Chemistry with tenure last year: Anna Mapp, an or- Department over the past year under the ganic/chemical biology chemist; Melanie New Faculty...... 2 outstanding leadership of Professor Mark Sanford, an organic/inorganic chemist; and Faculty News...... 3 Meyerhoff (Chemistry Department Chair, Eitan Geva, a theoretical/computational Faculty Profiles...... 4-5 1/09 – 7/10). We are very thankful for Pro- chemist. These faculty members were fessor Meyerhoff’s brilliant performance promoted based on their outstanding ac- Graduate Program News in recruiting new faculty and staff as well complishments and efforts in all three areas Degrees...... 6 as managing the budget and departmental of the department: research, teaching and policy. service. Finally, many Chemistry faculty Awards...... 6 members were recognized with awards Novartis/Fajans...... 7-8 The Department is making enormous over the past year, including: Michael Mor- Undergraduate Program News strides towards becoming one of the top ris, named the Richard D. Sacks Collegiate Chemistry programs in the nation, as Professor of Chemistry; A. Ramamoorthy, Degrees...... 8 validated by increases in the departmental elected fellow of the American Associa- Awards...... 9 ranking in recent surveys. Over the past tion for the Advancement of Science; and Summer Programs ...... 9 year, the Department recruited a large Melanie Sanford, awarded the National class of high quality graduate students Fresenius Award, the ACS Award in Pure Gifts...... 10 and added two new assistant professors: Chemistry, and the 2010 John Dewey Alumni News ...... 11-12 Pavel Nagorny, a synthetic organic chemist Award for teaching excellence. Further, In Memoriam/Bob Taylor ...... 13 who is supported by the newly established we learned recently that Raoul Kopelman Robert A. Gregg endowed professorship, will receive the 2011 Pittcon Analytical Faculty Listing...... 14 and Nate Szymczak, an inorganic and ma- Chemistry Award. Alumni Reply terials chemist. Dr. Szymczak’s hire is the Form ...... inside back cover Chemistry component of a university-wide Over the past year the University of interdisciplinary effort (including faculty Michigan and the state of Michigan have hires in the colleges of LS&A, Engineering, been struggling to deal with the economic and the School of Natural Resources and downturn. The Chemistry Department is Environment) focused on Energy Storage overcoming these challenges by enhanc- and funded by the Interdisciplinary Junior ing our external research profile and de- Faculty Initiative through the Provost’s and velopment efforts, and by increasing the 2010 President’s offices. This initiative coin- efficiency of our teaching and research cides with a state-wide focus on research operations. The generous support of our The Regents of the University of Michigan: and development in the areas of batteries research and teaching efforts by alumni Julia Donovan Darlow, Laurence B. Deitch, Denise Ilitch, Olivia and renewable energy. (and others) has become increasingly P. Maynard, Andrea Fischer Newman, Andrew C. Richner, S. important for maintaining and enhancing Martin Taylor, Katherine E. White, Mary Sue Coleman, ex officio. We are also proud to announce that three Mary Sue Coleman, president. excellence in all areas of the department. The University of Michigan is an equal opportunity/affirmative faculty members were promoted from As- Among other efforts, this support allows us action employer.

2010 U-M DEPARTMENT OF CHEMISTRY to engage University of Michigan under- that you are in town. I look forward to lactimidomycin. Incednine is a natural graduates in summer research projects and talking with you. macrolide isolated from the culture broth to enhance the research experience of the of Streptomyces sp. ML694-90F3. This Best wishes, Chemistry graduate students. On behalf of compound has been shown to suppress the the students and faculty who benefit from Carol Ann Fierke, Chair activity against the anti-apoptotic function this support, I thank you sincerely and Jerome and Isabella Karle Professor of of Bcl-2/Bcl-xL proteins of human small invite you to visit the Department anytime Chemistry and Professor of Biological cell lung carcinoma Ms-1 cells in 100nM Chemistry concentrations when combined with known anti-tumor drugs. Lactimidomycin is a macrolide isolated from Streptomyces amphibisporus. This natural product is a selective inhibitor of cancer cell migra- tion (100 nM range). It is also cytotoxic and exhibits antiproliferative properties Spotlight: Profiles of New Faculty in vivo against various tumors including MDA MB 231 human breast adenocarci- We highlight faculty members who have joined the Department since the last newsletter. noma. Our objective is to develop total Their appointment speaks well for our future. syntheses of these and related anticancer natural products and use those syntheses Pavel Nagorny demonstrat- as platforms for the preparation of simpler and more potent anticancer therapeutics. Assistant Professor ed therapeu- PhD: Harvard University tic value. It Glycobiology and glycoprotein syn- PostDoc: Memorial Sloan-Kettering Can- is our goal thesis is an important component of our cer Center to develop research program, and we believe that p r a c t i c a l developing new synthetic tools for the Total Synthesis, Chemical Glycobiology s y n t h e t i c carbohydrate synthesis, glycoconjugation, methods of and peptide ligation will facilitate our Research and Teaching Interests broad utility understanding of glycoprotein function and apply The research interests of our group lie and properties. Our group has a long- them to the standing interest in accessing synthetic in the areas of target-oriented synthesis and synthesis of new reaction development. The potential polysialic acids and their conjugates to complex natural products and glycocon- immunogenic proteins. 2,8-polysialic acid synthetic targets range from small mol- jugates for the studies in medicine and ecule natural products to glycoproteins of has been identified as an important small glycobiology. cell lung cancer (SCLC) marker that was Synthesis of natural products with found in nearly every patient examined. It is our ultimate goal to explore the pos- demonstrated anticancer activity is of high Department of Chemistry interest to our group. Among the various sibility of using 2,8-polysialic acids for targets that we are planning to synthesis the vaccination against small cell lung and Newsletter are the natural products incednine and related cancers. is published once a year by the Department of Chemistry at the University of Michigan, Ann Arbor, MI 48109-1055

Nathaniel Szymczak could lead to Assistant Professor new ways by PhD: University of Oregon which chemi-

Printed on Recycled Paper PostDoc: MIT, Cal Tech cal feedstocks are processed Energy Science, Inorganic Chemistry, and recycled Chair: Carol Fierke Materials Chemistry, with minimal Editor: Arthur J. Ashe, III Organometallic Chemistry energy input. Publication: Agnes Soderbeck H o w e v e r , Alumni News: Arthur J. Ashe, III, Robert Kuczkowski Research and Teaching Interests many aspects of the under- With a rising global population and lying science increasing industrialization, the need to behind such strategies must be developed Web Address: establish new and energy-efficient chemi- prior to large-scale implementation. To cal conversion schemes is vital. Investiga- http://www.umich.edu/~michchem address these issues, our research program tions into the discovery and implementa- E-mail: [email protected] will uncover new strategies to develop tion of innovative conversion schemes

2 2010 catalytic methods for energy recycling 2) The development of catalysts to ef- H+/H– equivalents to a substrate with par- and delivery. ficiently hydrolyze urea (typically present ticipation from the secondary coordination at ~0.3 M in urine) found in agricultural sphere of the ligand(s) and also give rise Several of these approaches are fun- and human waste streams to release ammo- to unusual modes of activation. damentally new/unexplored, which make nia and thus recycle the “fixed nitrogen.” these projects an exciting area of research A large synthetic effort is required to We will design catalysts based on cues to pursue, with the possibility to uncover develop these alternative energy recycling that has provided, to facilitate the high-impact results. Our research program strategies. Therefore, our group will use binding and hydrolysis of urea at non- has several components: a variety of inorganic synthetic air-free traditional metal sites to release and recycle techniques (Schlenk, glovebox, high 1) The construction of inorganic elec- the energy-rich ammonia that is otherwise pressure reactivity) to prepare the new trocatalysts that directly regenerate a discarded. Studies based on these unusual molecular constructs and use a battery hydrogen-storage material by electrocata- catalyst designs will also aim to understand of physical methods (e.g. NMR and IR lytic hydrogenation. This is fundamentally the underlying concepts of how secondary spectroscopy, X-ray crystallography, new approach that we will explore for the coordination-sphere effects modulate bind- electrochemistry) in order to assess their regeneration of spent ammonia borane fu- ing and activation of substrates. catalytic efficacy. When successful, our els, which are arguably the most promising 3) The design of catalysts for the ef- efforts will change the way that we think materials to study for hydrogen storage. ficient delivery of H to appropriate sub- about energy-recycling/storage strategies. Accomplishing this goal will translate to 2 strates. These studies will examine how H the viability of a material with the highest 2 can be directed to heterolytically deliver known reversible H2 storage density.

Faculty News

Hashim M. Al-Hashimi has received States. The award was presented last 1982 and was appointed to the Lawrence S. the Robert L. Kuczkowski Faculty Career November at a ceremony at the Willard Bartell Collegiate Professorship in 2001. Development Award and has been named Intercontinental Hotel in Washington, Dimitri’s research focused on the syn- the Robert L. Kuczkowski Professor of DC. A brief record of the award address is thesis and characterization of iron sulfur chemistry. A recent article by Hashim and available at the Professors of the Year web clusters that informed on the role of these coworkers, “RNA Dynamics by Design: site: http://www.usprofessorsoftheyear. systems in a wide range of metalloenzymes. Biasing Ensembles Towards the Ligand- org/winners/winners09.cfm His seminal work relating to the FeMoS Bound State” was featured on the cover cluster in the enzyme nitrogenase has been of Angew. Chem. Int. 2010, 49(33), 5731. cited thousands of times. He pioneered the Charles L. Brooks, III was selected to use of metallosupramolecules as molecular receive the Purdue University Outstand- transport agents across membranes. His ing Alumni award for 2010. The award research resulted in over 200 publica- was in recognition of his contributions tions, book chapters, and presentations at in biophysical chemistry, particularly in international meetings. His honors include modeling the structures and interactions the University’s Distinguished Faculty of biomacromolecules. Achievement Award and the Margaret and Herman Sokol Award in Sciences, as well Kate C. Carroll and Kristina Karb- Peter Alaimo, Brian Coppola and Mark as the Alexander von Humbolt Research stein have left the University and are Meyerhoff at the award ceremony Award, a Guggenheim Fellowship, an now at the Scripps Research Institute in Alfred P. Sloan Fellowship and election Jupiter, FL. Dimitri N. Coucouvanis ,Lawrence S. as a fellow of the American Association Brian P. Coppola was selected as a Bartell Collegiate Professor of Chemistry, for the Advancement of Science. 2009 U.S. Professor of the Year by the retired from active status in May and was Theodore Goodson, III is a recipient of Carnegie Foundation for Advancement of appointed Professor Emeritus. Professor a 2010 NSF American Innovation Fellow- Teaching and the Council for Advance- Coucouvanis received his BS degree from ship in the Division of Materials Research. ment and Support of Education. Founded Allegheny College in 1963 and his PhD in 1981, the U. S. Professors of the Year from Case Institute of Technology in 1967. Kristina Hakansson is now serving on Award is given to a single professor na- He completed a postdoctoral research fel- the Board of Directors of the American So- tionwide each year (in the Doctoral and lowship at Columbia University in 1968, ciety for Mass Spectrometry (2009-2011). Research category) who has demonstrated and from 1968-83 he served on the faculty Paul R. Jones has been selected as a “extraordinary dedication to undergradu- of the University of Iowa. He joined the 2010 ACS Fellow. Paul had been a faculty ate teaching.” Brian was selected from University as a Professor of Chemistry in member of the Chemistry Department of more than 300 top professors in the United the University of New Hampshire 1956-

U-M DEPARTMENT OF CHEMISTRY 3 1995. Since his retirement in 1996 he of Paris (Orsay). He also received the sored by the Alpha Chi Sigma Fraternity has been a visiting scholar in the UM Vandis Award for his contributions to the and the Alpha Chi Sigma Educational Chemistry Department. He is the Editor chemistry of vanadium. His award address Foundation. Both awards are presented of the Bulletin for the History of Chemistry was delivered at the 7th International Sym- annually to an outstanding chemist under 1995-2011. He also advises the UM ACS posium on the Chemistry and Biological the age of 35 who has achieved national Affiliates. Chemistry of Vanadium held in Toyama, recognition. Melanie is the first member Japan in October. Vince was a plenary of our Department to receive the Fresenius Nicolai Lehnert and W. Robert Scheidt speaker at EUROBIC in Thessaloniki, Award, which has been in existence since (PhD 1968, Paul Rasmussen) organized Greece. He will be a keynote speaker at 1965. The Award in Pure Chemistry was an Inorganic Chemistry FORUM, “ The AsiaBIC In Kaioshiany, Taiwan and at initiated in 1931. Lawrence Brockway Coordination Chemistry of Nitric Oxide the Pacificchem conference in Honolulu (1940) and Lawrence Oncley (1942) were and Its Significance for Metabolism, Sig- this fall. In addition he will be a Taiwan only prior awardees from the Department. naling and Toxicity,” which was published National lecturer in the fall. The list of other prior awardees includes Inorganic Chemistry 2010, 49 in (14). many of the giants of our field! Melanie Ayyalusamy (Rams) Ramamoorthy Anne J. McNeil was awarded a 2010 was also awarded the 2010 John Dewey was elected a fellow of the American As- NSF Career Award. On November 8 she Award by LSA for long term commitment sociation for the Advancement of Science moderated an Aldrich Materials Science to undergraduate students. (AAAS) in 2009. He was a Willsmore sponsored C&EN Webinar on “Complex Fellow of the University of Melbourne, Nils G. Walter is the principal investi- Macromolecular and Nanoscale Structures Australia, and the keynote speaker in the gator of a recently funded $1.7M NSF Ma- by Combinations of Living Radical and Australian Biophysical Society meeting in jor Research Instrumentation grant which Ring Opening Polymerizations.” 2009. He is a guest editor for the special will fund the Single Molecule Analysis in John Montgomery and coworkers issue on ,”Membrane Protein Dynamics: Real-Time (SMART) Center. The SMART have written an article on nickel catalyzed Correlating Structure to Function,” in center in room 3080 Chemistry will coupling of aldehydes and acetylenes (J. BBA Membranes Journal. He was re- house three open-access single molecule Am. Chem. Soc., DOI: 10.1021/ja102262v) cently selected for the Editorial Board of microscopes which will greatly enhance which was featured as a Highlight in the journal Magnetic Resonance. the capability for high-content screening C&EN. of biological samples one molecule at a Melanie Sanford has been recognized time. The Center will have a ten-member by two very important 2010 awards by the Vincent L. Pecoraro has been selected faculty steering committee, led by Profes- ACS. These are the National Fresenius as a 2010 ACS Fellow. He was also selected sor Walter, and a Laboratory Director, Dr. Award sponsored by the national chemical for a 2010 Blaise Pascal International Re- Tristan Tabouillot, who is performing the honorary society Phi Lambda Upsilon and search Chair which will allow him to spend day-to-day operation. his 2011 sabbatical leave at the University the ACS Award in Pure Chemistry spon-

Faculty Profiles

Michael D. Morris was re- State University, where he or has served on the editorial boards of cently named the Richard D. conducted studies of the several journals in analytical chemistry, Sacks Collegiate Professor of electrochemistry of or- applied spectroscopy, biomedical optics Chemistry. Collegiate chairs ganometallic compounds, and skeletal structure and biochemistry. He honor the recipient and a for- with a brief excursion into edited the first monograph ever published mer faculty member for whom Raman spectroscopy. Mike on chemical imaging and he co-edited the chair is named. The late moved to the University of (with Pavel Matousek) a recently published Professor Sacks, himself a dis- Michigan in 1969 and his monograph on biomedical and pharmaceu- tinguished analytical chemist, interests soon shifted from tical applications of Raman spectroscopy. was a faculty member in our electrochemistry to Ra- He has served the Chemistry Department Department from 1969 until his man spectroscopy. Since in many capacities, including five years as untimely death in 2006. coming to Michigan, Mike Associate Chair for the Graduate Program. has made many important Mike Morris was born in Throughout his career Mike made contributions to biomedical New York City and raised in important contributions to both the ap- spectroscopy and to biopolymer capillary New Jersey. He received a B.A. in Chemis- plication of Raman spectroscopy and to electrophoresis. He has been honored try from Reed College in Portland, Oregon spectroscopic instrumentation. He worked with awards from the American Chemical and a Ph.D. from Harvard. Doctoral work with several companies in Michigan and Society, Society for Applied Spectroscopy, in electrochemistry was performed with elsewhere on the use of Raman spectros- Anachem Society and by LSA and Univer- Professor J.J. Lingane. He then joined copy to solve problems in their product sity of Michigan. He has presented named the Chemistry faculty of Pennsylvania lines. On the technology side he developed lectures at many universities. He serves

4 2010 several methods for Raman spectroscopic School and School of Dentistry and with electrophoretic separations and Raman imaging and was the first to use multivari- researchers in other institutions. They have spectroscopy enabled the laboratory to be ate methods to extract information from used Raman spectroscopy in projects as the first to do on-capillary Raman spectro- Raman images. Mike is also one of the diverse as evaluating the chemistry of tis- scopic detection. pioneers of coherent Raman spectroscopy. sue failure in bone fractures, elucidating Mike has taught courses at every level He was the first to demonstrate resonance the normal and pathological chemistry of of the graduate and undergraduate curricula enhanced stimulated Raman spectroscopy bone mineralization and development of and has participated in several undergradu- (then called inverse Raman spectroscopy) diagnostics for early stages of musculo- ate and graduate interdisciplinary courses. and the first to apply stimulated Raman skeletal system disorders. This research Several years ago he led a team that com- spectroscopy to the study of highly fluo- program has recently expanded into pletely revised our introductory analytical rescent biomolecules, including flavins and development of methods for monitoring chemistry laboratory and lecture courses. bile pigments. More recently he developed development of tissue constructs for soft At the graduate level he developed and methodology for non-invasive in vivo tissue replacement following oral surgery. taught courses in analytical spectroscopy Raman spectroscopic imaging and has His capillary electrophoresis program has and instrumentation. even demonstrated non-invasive Raman focused on nucleic acid separations. His tomography. group showed how to do rapid (seconds Mike has been happily married to Leslie to minutes) pulsed field capillary elec- Morris for many years. Together they raised Over the last decade Mike established trophoresis. Using high frame rate video four children - two sons and two daughters. Raman spectroscopy as an important tool microscopy they elucidated the different Leslie has served multiple terms on the Ann in basic musculoskeletal science and mus- migration dynamics of single stranded, Arbor City Council and remains active in culoskeletal disorder diagnostics. Work in double stranded and supercoiled DNA. local civic affairs. Mike and Leslie enjoy this area was featured in the cover story of They also established that slow relaxation the landscape, food and art of the Pacific the September 20, 2010 edition of Chemical of the solutions of entangled linear poly- Northwest. They are frequent visitors to and Engineering News (online: http://pubs. mers used as electrophoretic separation Portland, Oregon (where they met as col- acs.org/cen/coverstory/88/8838cover. media caused the peculiar asymmetric lege students), Seattle (where they were html). He works with several collaborators shapes of DNA electrophoresis bands. married), and the coastal towns of both in the University of Michigan Medical Additionally, melding the themes of Oregon and Washington.

Raoul Kopelman started his professional for instance surgery, oncology, neurotoxicology, and career at Michigan working on solid state during inter- biomedical engineering on stratagems of physical chemistry projects, including nal changes improving brain tumor surgery, by visibly exciton and energy transport in perfect due to bacte- delineating its boundaries, and amplify- molecular crystals, with applications to rial infections ing it with intraoperative photodynamic artificial photosynthetic units, including or chemical eradication of tumor leftovers. A paper dendrimer supermolecules (in collabora- toxins. This on advances in effective treatment of ovar- tion with Dr. Jeff Moore, then at Michigan). w o r k h a s ian tumors is in press (Cancer Research). The same work also resulted in making the been impor- Similar work is going on with colleagues first nanometer scale light source, based on tant also in in cardiology with the aim of alleviating anthracene nanocrystals. This led Kopel- the context arrhythmia. In work concerning bacterial man to first define the term “nanophoton- of national infection, a University of Michigan spinout ics” which has turned into a large area of c o u n t e r - (“Life Magnetics”), led by Kopelman’s re- research (and even a name of a journal). pathogen pro- cent Ph.D. student Brandon McNaughton Based on nanophotonics Kopelman devel- grams. Basic advances in understanding the was formed this year and gained signifi- oped the first nanoscale optical chemical makeup of live cells were also made, such cant venture backing. It is based on an sensors, which evolved into nanoparticle as a discovery of unexpectedly high electric invention where cell magnetorotation is sensors for biochemical investigations fields throughout the cytosol. Kopelman’s used to enable ultra rapid monitoring of inside live cells, so called nano-PEBBLEs next plunge was into medical applications bacterial antibiotic susceptibility (in hours (Photonic Explorers for Biomedical use by of the above. He defined the concept of vs. the days it takes now). This device is Biologically Localized Embedding). This multi-functional targeted nanoparticles, especially promising in view of the new marked Kopelman’s plunge into Analytical for theranostics (combination of therapy strains of bacteria that are immune to most Chemistry, making the world’s smallest and diagnostics). For instance the same antibiotics. sensors for many molecules, ions, and free nanoparticle applied for targeted chemo- Last year (just before the Obama stimu- radicals. At the same time similar optical therapy, or photodynamic therapy, also lus programs) Kopelman testified in front nanosensors were made for measuring enhanced the contrast of MRI or CT. To- of a congressional subcommittee, lobbying physical properties, such as electric field, day many pharmaceutical companies are for increased funding of NIH. Over the viscosity, temperature, and magnetic prop- working on such theranostic medicines last year Kopelman was invited to lecture erties. These sensors enabled discovery of (“nanomedicines”). Presently Kopelman at both the chemistry and physics institutes cells under normal and stressed conditions, is collaborating with colleagues in neuro-

U-M DEPARTMENT OF CHEMISTRY 5 of the Chinese Academy of Sciences. He gave the Iddles Award University. He has also been awarded the prestigious Pittcon Lecture at the University of New Hampshire, gave the Plenary Analytical Chemistry Award (to be presented in March 2011). Lecture at the Inauguration of the Nanophotonic Institute at Duke

Graduate Program News Graduate Degrees - Masters & Ph.D August 2009, December 2009, May 2010 & August 2010

Doctorates Lin Wang Mark Meyerhoff Polymer Membrane Based Optical and Electrochemical Anion/ Ryan James Casey Anna Mapp Polyanion Sensors. Design and Synthesis of Non-Peptidic Transcription Factors.- Jesse Dylan Ward James Penner-Hahn Nicholas Ryan Deprez Melanie Sanford Applications of Synchrotron Radiation to the Structure, Localiza- Development of and Mechanistic Insights into Palladium-Cata- tion, and Quantitation of Zinc in Biological Systems. lyzed C-H Arylation Reactions. Eric Scott Wiedner Marc Johnson/Melanie Sanford Jonathan Andrew Fritz John Wolfe Triple-Bond Metathesis with Group 6 Nitrido Complexes: The Pd-Catalyzed Carboamination Reactions for the Synthesis Importance of Ligand Identity and the Development of XXX Pincer ofImidazolidin-2-ones and Related Heterocycles. Ligands. Meng Guo Theodore Goodson III Susan Diane Wiedner Edwin Vedejs Investigations of Novel High Dielectric Materials and New Synthetic Studies toward Aziridinomitosenes and 9-Oxo- Mechanisms. pyrrolo[1,2-a]indole Mitosanes Related to the Mitomycin and FR Heterocycles. John Timothy Henssler Adam Matzger Structure-Property Relationships in Conjugated Oligomers Con- Biyun Wu Mark Meyerhoff taining Thieno [3 2-b] thiophene and Thieno [3 2-b] furan. Development of Hemocompatible Polymeric Materials for Blood- Contacting Medical Devices. Marisa Louise Macnaughtan Marc Johnson/Adam Matzger Ruthenium-Catalyzed Metathesis with Directly Functionalized Jun Yang Mark Meyerhoff/Omar Yaghi Olefins. Potential Anti-Thrombotic Nitric Oxide Generating Layer-By- Layer Assembly. Khoi Tan Nguyen Zhan Chen Studies of Interactions between Peptides/Proteins and Lipid Bilay- Miri Yoon E Neil Marsh ers using Sum Frequency Generation Vibrational Spectroscopy. Mechanistic Studies on AdoCbl-dependent Glutamate Mutase. Jian Pei Robert Kennedy High-throughput Chemical Analysis Using Capillary Electro- phoresis and Electrospray Ionization Mass Spectrometry with Masters Allison Rose Knauff Ramya Krishnan Applications to Drug Screening. Timothy Colin Berto Kira Beth Landenberger Thaddeus Thomas Boron III Miguel Jose Pereira Nils Walter Zhenxin Lin Single Molecule Characterization of the Varkud Satellite Ribo- Tanya Breault Xin Liu zyme and Bulk Native Purification of Non-coding RNA. Jing Chen Sharon Rose Neufeldt Kevin Hartman Kendra Rae Reid Robert Kennedy Yuta Suzuki Aireal Diane Jenkins Development and Application of Analytical Instrumentation for Melissa Lynn Zastrow Alexander Edmund Johnson- Monitoring Function of Islets of Langerhans. Wen Zhou Buck Kristin Noelle Schultz Robert Kennedy Using Microdialysis Coupled On-Line to Capillary Electropho- resis to Study the Effects of Estradiol and Psychostimulants on Neurotransmitter Release. Dongxuan Shen Mark Meyerhoff Graduate Awards The Study of Apo-Enzymes/Prosthetic Groups and Their Applica- tions inChemical Analysis. Departmental Awards Alumni Fund Outstanding Randon H Walker Mark Banaszak Holl Graduate Student Research Silylene and Germylene Activation of Alkane, Ether and Amine American Chemical Society Award C-H Bonds Mediated by an Aryl Halide. Observation of an Aryl Outstanding Graduate Nicholas Ball (Sanford) Halide Kinetic Isotope Effect for the C-H Activation Reaction. Student Award for Research Robert and Carolyn Buzzard Li Wang Gary Glick and Teaching Graduate Chemistry Probing Lymphocyte Responses to Modulation of F0F1-ATPase by Joseph Braymer (Lim) Student Leadership Award BZ-423.

6 2010 Kevin Hartman (Ramamoor- Departmental Novartis Graduate Poster Session Travel thy) Fellowships Fellowship in Organic Awards Florence Fenwick Chemistry Analytical Cluster: Georgia Lemen (Wolfe) Outstanding Graduate George Ashworth Analytical Kee Scholten Student Instructor Award Chemistry Fellowship Rackham Merit Fellowships Thomas Slaney (Kennedy) Christopher Avery (Chen) Hangtian Song (Hakansson) and Science Awards Andrew Boughton (Chen) Milton Tamres Outstanding Robert W. Parry Award Lindsay Amos (Zellers) ChemBio Cluster: Andrea Bell (Meyerhoff) Teaching Award Lauren Goodrich (Lehnert) Joseph Yourey (Bartlett) Chun Chow (Matzger) Cheryl Moy (McNeil) Peter A.S. Smith Fellowship Kristoffer Brandvold Andrew Crawford (Fierke) Shana Santos (Sollner) Jennifer Schnobrich Chelsea Huff (Sanford) Training Grants (Matzger) Se Ryeon Lee (McNeil) Saumen Chakraborty (Pecoraro) Margaret & Herman Organic Cluster: Cellular Biotechnology Heidi Phillips (Dunietz/Geva) Sokol Graduate Summer Training Program (CBTP) Jefferson Plegaria (Pecoraro) Nicholas Ball (Sanford) Research Fellowship Mallory Van Dongen (Ban- Wei Li (Montgomery) Kathryn Dooley (Morris Hasnain Malik (Montgomery) aszak Holl) Sharon Neufeldt (Sanford) Chemistry-Biology Interface Winter Term Departmental Anna Wagner (Sanford) Physical Cluster: Training Program (CBI) Fellowships Rackham One-Term Heidi Phillips (Dunietz/Geva) Christopher Taylor (Mapp) Dissertation Fellowship Surma Talapatra (Geva) Melissa Zastrow (Pecoraro) Seokhoon Ahn (Matzger) Jessica Anna (Kubarych) Ryan Baxter (Montgomery) Materials Cluster: Graduate Assistance in Timothy Berto (Lehnert) Bo Wang (Hakansson) Kelsey King (McNeil) the Area of National Need Zachary Buchan (Montgom- Erica Lanni (McNeil) (GAANN) ery) Vaughan Symposium Wen Wen (Maldonado) Jameson Bothe (Al-Hashimi) Elizabeth Dethoff (Al-Hashi- (PECRUM) Awards - Jing Chen (McNeil) Alaina Detoma (Lim) mi) Vilmali Lopez-Mejias Deidra Gerlach (Coucouvanis/ 2010 Inorganic Cluster: (Matzger) Lehnert) Amanda Hickman (Sanford) Dow Chemical Oral Cheryl Moy (McNeil) Joseph Jankolovits (Pecoraro) Matt Remy (Sanford) Presentation Travel Award Joshua Neukom (Wolfe) Qiang Li (Kennedy) Melissa Zastrow (Pecoraro) Ross Putman (Matzger) Jonas Locke (McNeil) Hasnain Malik (Montgomery) Brannon Gary (Sanford) Emily Salans (Wolfe) Ravi Nanga (Ramamoorthy) Oral Presentation Awards Danielle Schultz (Wolfe) Dustin Patterson (Marsh) Kira Landenberger (Matzger) Anne Vazquez (Chen) Aleksandrs Prokofjevs (Ve- Tim Berto (Lehnert) Francisco Vazquez (Geva) dejs) Amberlyn Wands (Mapp) Amanda Ward (Wolfe) Molecular Biophysics Yingda Ye (Sanford) Training Program (MBTP) Hyun Ju Yoo (Hakansson) The Novartis Symposium Alexander Johnson-Buck Yueyang Zhong (Ruotolo) (Walter) On August 12, 2010, the Department was fortunate to host Stephanie Le Clair (Rama- Non-Departmental our second annual Novartis Symposium. As with the previous moorthy/Chen) symposium, the exciting day of science was a mix of poster Pharmacological Sciences Awards presentations, student talks and seminars by outside speakers. & Biorelated Chemistry ACS Division of Analytical Forty students and postdocs presented posters over a broad range Training Program (PSTP) Chemistry Nine-Month of topics. As with last year the judging was extremely difficult Grant Sormunen (Montgom- Fellowship due to the many exciting results and strong presenters, and the ery) Meng Wang (Kennedy) judges worked diligently throughout the afternoon to winnow Regenerative Sciences down the field. While they did so, attendees enjoyed four out- Training Grant Eli Lilly Fellowship standing talks. Kicking off the event was Dr. John Tallarico, the Kathryn Dooley (Morris) Kara Stowers (Sanford) Head of Chemogenomics at the Novartis Institute of Biomedical John-David McElderry (Mor- National Science ris) Research with a seminar entitled ‘Dissecting the fundamentals Foundation Fellowship of disease using chemical genetics’. Dr. Tallarico’s group at Training Program Amanda Hickman (Sanford) in Reproductive Novartis has been responsible for the discovery of a number of Chelsea Huff (Sanford) exciting small molecule bioactives, including a recent inhibitor Endocrinology (RSP) Stephanie LeClair (Rama- of the Wnt signaling pathway, and the audience enjoyed hearing Gwendolyn Anderson (Ken- moorthy) nedy) Amy Speelman (Lehnert) the details of the discovery process illuminated. Two student talks National Institutes of Health Erica Speelman (McNeil) followed, with Nick Ball (Sanford group) providing an excellent Pre-doctoral National National Science account of his exciting progress in developed a method by which Research Service Award Foundation East Asia and CF3 groups can be incorporated into small molecules using pal- Nicholas Ball (Sanford) Pacific Summer Institute ladium as a catalyst. Chris Rath (Sherman group) detailed his Fellowship multidisciplinary studies that have provided remarkable insight Joseph Braymer (Lim) into the biosynthesis of the chemotherapeutic agent ET-743. The scientific talks closed with a keynote lecture from Professor Mo

U-M DEPARTMENT OF CHEMISTRY 7 Movassaghi of MIT who described his most recent successful ture on, “The Struc- forays into the total synthesis of alkaloid natural products. To ture, Symmetry, and conclude the event, Dr. Larry Hamann (PhD 1991, Koreeda) of Stability of Two Di- Novartis announced the poster winners: Dr. Chinmay Majmu- mensional Crystals.” dar, Erica Lanni and Alaina DeToima and Tom Lyons. We thank Dr. Stefan Fajans Novartis for their sponsorship of this wonderful event and look [Kasimir Fajans’ forward to it in the years to come. son] and her men- tor Professor Adam Matzger attended Kasimir Fajans Dissertation Award the Departmental reception given for Dr. Katherine Plass, Dr. Stefan Fajans and On March 27, 2010 Dr. Katherine Plass received the Kasimir Dr. Plass prior to the Professor Adam Matzger at the reception. Fajans Award for the most outstanding dissertation for the years lecture. Her name has 2006-2007. Dr. Plass who is currently an assistant professor at been placed on a bronze plaque on permanent display in the main Franklin and Marshall College in Lancaster, PA, delivered a lec- conference room of the Chemistry Building.

Undergraduate Program News Undergraduate Degrees August 2009, December 2009, May 2010 & August 2010

Bachelor of Science. Ramsay Macdonald Bachelor of Science. Qiyang Jin Biochemistry Kalev Maricq Chemistry Concentration Matthew Kole Jared Babcock Shari Martin Thomas Chae Eric Kushion Nicholas Bailey Christopher McHugh Christopher Chiles Lindsey Lapointe Jeffrey Bqyar Zachary Miller Madeleine Ewers Thomas Lauzon II Charles Bunzey Rebecca Minich Matthew Henderson Jonathon Mahlow Melody Campbell Anders Nilsson Bradley Holden Kaitlin McLoughlin Carol Chan Jordan Pecherer Andrew Parth Christine Morrison Peter Chockley Matthew Pentis Adam Runkle Alexander Pagliaro Gamtt Coyan Robyn Pratt Bryan Tebeau Hyung Min Park Jennifer Cui Ian Raxter Matthew Wall Christopher Rumble Umair Daimee Benjamin Root Miguel Wong Melanie Sabbagh James David Jeremy Ruskin Phillip Stratton Leslie Demers Konrad Sawicki Bachelor of Science in Mary Tran Christopher Dion David Schauder Chemistry Kristen Wiese Jennifer Dolan Lucy Shi Vivek Behera Joshua Young Matthew DuPrie Tamar Shrikian Ryan Bradstreet Nasir Fakhri Eric Smith Mari Brunner Bachelor of Science Sarab Garnai James Stewart Kenneth Chen Chemistry Biochemistry Robert Gildersleeve Rachel Sullivan Samantha Cummings Concentration Neetu Gulati Kyle Terpak Sara Edgar Lauren Heath Ivy Tran Vivek Behera Siltia Escudero James Ignatz-Hoover Jing Yang Ryan Bradstreet Matheus Falasa Erin Kropp Juno Yoo Kenneth Chen Danika Forgach Jullia Lee Grace Zhu Matthew Kole Christina Galloway Sora Lee Jonathon Mahlow Matthew Gray Mitlin McLoughlin

Undergraduate Awards Alumni 1st Year Achievement Awards Kevin Joseph Benjamin Levin, Shai Madjar, Anna Maurer, Connie Shi CRC Outstanding Achievement Award Summer Research Awards Nicole Stegmeier Alpha Chi Sigma Outstanding 1st Year Student Award Seyhan Ege Undergraduate Research Fellowships Holly Williams Chloe Bass (Nichols/Fierke), Joshua Bornstein (Garneau-Tsodikova), Daniel Camacho (Matzger)

8 2010 James E. Harris Scholarship Alumni Outstanding Awards Azhar Carim (Maldonado), Eric Chen (Bochar), Rebecca Chota 2nd Year Student, Joel Hrit (Koreeda), Aaron Goodman (Bartlett), Christopher Grondin (Glick), 3rd Year Students, Michael Kheir, Samer Salamekh, Christina Suh Kimberly Haupt (Walter) Senior Year Student, James Ignatz-Hoover Novartis Undergraduate Research Fellowships Honors College Vanko Award, Vivek Behera Melissa Hoffman (Lehnert), Dorota Marchel (Marsh) Huron Valley Section of the American Chemical Society- Outstanding Student Leadership Award PPG Undergraduate Awards Jonathon Mahlow Austin McHenry (Ramamoorthy), Khalil Mroue (Walter) American Chemical Society Analytical Chemistry Awards William G. Smeaton Memorial Awards Aaron Goodman Samer Salamekh (Ramamoorthy), Kamya Sankar (Goldstrohm), Erica Saunders (Lei) Seyhan N. Ege-WISE Award Margaret & Herman Sokol Endowment Awards Sarah Garnai Jesse Song (Carroll), Christina Suh (Pecoraro), Britt Wedenoja Merck Index Awards to Outstanding Seniors (Matzger), Brittany Worley (Meyerhoff) Kareem Alazem, Jennifer Cui, Kaitlin McLoughlin, Konrad Sawicki, Division of of the American Chemical Elizabeth Shy Society 2010 Summer Undergraduate Research Fellowship American Institute of Chemists Biochemistry Award Anthony Grillo (Koreeda) James David American Institute of Chemists Chemistry Award Christine Morrison

Undergraduate Programs

University of Michigan Research Experiences for International Summer Undergraduate Research Undergraduates Site in Chemistry Exchange with China

Each summer, since 1989, ten students from around the United In 2007, the University of Michigan Chemistry Department States make up the University of Michigan REU Site in the Chemical created the first truly bilateral undergraduate research exchange Sciences. These REU students will join the chemistry department’s program, in the sciences, between China and the United States. active undergraduate research cohort of 60-70 local and interna- Starting then with a pilot project, with seven total students, the tional students program has grown, in 2010, to include 50 students per year (25 in a 10-week in each direction). Using partial funding from the National Sci- program of re- ence Foundation, many of the US-to-China positions within the search and pro- existing UM program are completely open to students from around fessional devel- the US. US students are placed in research groups in the chemical opment. REU and biological sciences at Peking and Tsinghua Universities, in participants are Beijing, arguably the two premier research institutions in China. recruited na- Additional funding has come from the universities, from their tionally, with faculty and donors, and from Pfizer Global R&D. While productive an intentional, research in both countries is certainly the most tangible outcome, strategic em- an equally significant result is the increased sense of global and phasis on build- international confidence experienced by these students, who ing a cohort that REU students, Summer 2010 have fully integrated these experiences as a natural part of their represents di- verse backgrounds, settings, and experiences. Our assessment program shows that their experience in the department contributes greatly to students’ confidence to pursue graduate studies, and to their ability to make an informed decision about choosing scien- tific careers. We have tracked, at least in part, 195/214, or 91%, of the students from 1989-2010. Of these 214 students, 66+ have their Ph.D. degrees, 18+ have M.S. degrees, 25+ are currently attending graduate school, 55+ at least earned the B.S. (with 30+ in industry), 9+ obtained their MD, DDS or JD, and 14 are still undergraduates. To date, 139/214 (65%) of our REU participants have been women, and 71/214 have been underrepresented mi- nority students (33%). More information about the program can be found at http://www.umich.edu/~reuchem/ PKU students, Summer 2010

U-M DEPARTMENT OF CHEMISTRY 9 undergraduate education. Above all, the program is concerned with providing all of its students with a quality education and a vision of a world with far fewer boundaries and limitations than any previous generation. Information about the program can be found at http://www.umich.edu/~michchem/UMPKU/

Gifts

Contributions from private and corporate donors received from July 1, 2009 – June 30, 2010

Chairman’s Discretionary Fund Thomas Houser and Carol Adair AT&T Foundation Albert John Highe and Shelia D. - Chemistry Houser Nora H. Bahr and James T. Bahr Mooney Highe R. Damrauer and Lenore B. Damrauer Jeffrey Duan Hsi and Amy Wagenfeld William Arnold Baker and Mrs. Baker Jeffrey Alan Housner and Allison Lea Antone L. Lott James Stafford Huston Ludvik Frank Barinka Housner Edwin & Roberta Przybylowicz Fund Thomas Michael Jackson John E. Bauman and Barbara C. Bau- Carole Goldman Hughes Jack Sweet Marilyn L. Jacob man Sonia Elise Hulman Howard H. Un Eric Todd Johnson Shyam Bhakta Intel Charitable Match Trust Account James M. Julian and Diana S. Hall Linda Biondo and Fred S Biondo Norman Peter Jensen and Sara L Muel- Chemistry Department Fund Julian Neal Benjamin Blatt ler Jensen David Willis Badger Phyllis W. Karseboom James Lee Brewbaker and Donna A. Mark Darren Johnston Evelyn P. Tyner Trust George B. Lowrie Brewbaker Robert Lindell Jones and Sylvia J. Joel Michael Goldberg and Barbara J. Merck Company Foundation Amanda Preston Buscetta and Steve Jones Burroughs John S. Muenter Buscetta Steven Ralph Jordan Thomas William Gougeon and Carolyn Walter Neal Opdycke and Ruth Ann C. William F. Cartwright and Cartwright Roland James Kern T. Gougeon Opdycke Angela Grace Cassar Janet Lenore Kochanny Harold Lewis Kohn and Carol Kohn William Anthony Pavelich Thomas A. Caughey and Ellen Wend- Richard Paul Kosinski P & G Fund James V. Pivnichny and Joan D. landt Caughey Kevan R. Kreitman and Barbara Kreit- Irvin Wilbur Potts and Rosemarie VanPelt John Michael Costantino man McReavy Potts Klaus Kurt Schmiegel and Joel Larkin Lee Arlen DeKay and Colleen M. David Lai Lee Russell E & Margaret G Price Trust Schmiegel DeKay William Lewis Erich Schulz and Suzanne Eva Schulz John Vincent Scibelli and Terene M. Dow Chemical Company Foundation Josephine E. Luton Walter S. Syrkowski Scibelli Dow Corning Corporation William Robert McDonell Richard F. Tomko and Rev Tomko Eleanor Jean Scott David William Ebdon and Priscilla A. Kirsten L. McKillop and Jay Thomas Veronica Hsiung Wiley Joseph William Shepard and Elfreda Ragle Ebdon McKillop Susan Lou Woodruff and Steven D. Shepard Sue Brown Eggling and Edward Myrtle S. McLain Trust Woodruff Hilary Edmund Snell and Kristi Dell Eggling Bret T. Mercer and Shelly LeWinter Norman Paul Arends Snell Michele Marie Eickholt and Lee Albert Merck Company Foundation BASF Corporation Gregg S. Spitler Green Thomas Joseph Messenger Timothy G. Bee Graham Deuer Stewart David W. Emerson and Shirley A. Douglas Gene Mikolasek and Audrey Lowell Orson Bird and Joanna K. Bird James Hunter Thirtle and Tonia Z. Emerson E. Hartline Mikolasek Gary Russell Chipman and Sally L. Thirtle Kathryn Lynne Fok and Kevin Fok Eric M. Monberg and Wendy Lee Chipman Lazarus D. Thomas Susan Ellen Forest Monberg Steven Anderson Clarke Robert Coral Tripp Shirley Scott Fraley and Bernam G. Timothy Edward O’Toole Renee Irene Cribbins Wen-Kuei Wong and Shaio-Wen Wong Fraley D. Eugene Overton Sue Ellen Delos and John Bernard William Koon Chong Wong Trust Howard Leroy Garrett Berj K Parseghian Delos Paul F. Zittel Sheldon D. Gerson and Marilyn A. Pfizer Foundation Dominion Foundation Gerson Irene Carmela Piscopo and James D. Chemistry Graduate Fellowships Richard R. Doyle and Judith Lang Dennis A. Glotzhober and Barbara B. Rodgers ACS Organic Division Doyle Glotzhober William A. Plautz Bristol Meyers Squibb Co. David Victor Duchane and Jacqueline Steven Rex Goates and Juliana Boerio- John Michael Powers and Susan M. Eli Lily Analytical Graduate Fellowship L. Church Duchane Goates Powers Agnes Soomi Kim-Meade and Eric Pui Luen Fan and Helen E. Fan Mark Thomas Goulet and Joung Goulet Christina Ma Rearick and Mark Rich- Albert Meade Patrice Geraghty and Robert Best Philip Larry Gravel and Christine A. ard Rearick Timothy F. Merkel and Theresa Marano Wilson Geatros Gravel Steven Charles Rifkin Merkel Thomas J. Giordano and Pam Giordano David Greenblatt and Sheila C. Robert D. Dunbar Trustee Novartis GlaxoSmithKline Foundation Greenlatt Mark Alan Roseman and Jo Ellen Schering-Plough Foundation, Inc. David Joel Hart Dean Lester Griffith Roseman Mary Ellen Heyde and Gordon Edward Chemistry Strategic Fund Barry P. Hart Thomas Michael Rosseel and Carol Parrington Ruth Marie Allen Alice Haddy Hellen and Edward H. Rosseel Kurt Walter Hillig and Kathy J. Dien August Joseph Altese Hellen Charles Albert Roth and Barbara Kelly Hillig Amgen Foundation Rebecca Dale Henry and Steven Patrick Roth Roland Felix Hirsch John George Anderson and Linda Adele Henry Walter E. F. Rupprecht and Joanne M. McHie David Paul Hesson and Jane P. Hesson Rupprecht

10 2010 Warren Kenneth Russ Kent P. Lanini Memorial Library Stewart Edward Gloyer and Marilyn Robert Kuczkowski Faculty Mary Catherine Ryan Stephen Lawrence Gaudioso and Me- Ann Gloyer Award Helen Schwarz Schaefer and John P. linda M. Gaudioso Jerome Phillip Horwitz and Sharon Z. Carol Ann Fierke Schaefer Xerox Corporation U.S.A. Newman Horwitz Robert L. Kuczkowski and Ann E. Mark Calvn Segel Charles Z. Hotz Milton Tamres Teaching Award Kuczkowski Stephen Hill Shane Johnson & Johnson Family of Compa- Robert M. Stewart Trust (Estate) Frances L. Adler and Irving M. Adler David Ludvik Siroky nies Contributions Fund Barbara T. Booker Estate Ashley Elaine Tan Norman Wayne Kalenda and Marion Seyhan N. Ege Junior Faculty Marjorie L. Clary Carter and Donald James Beyer Tchobanoff and Mariann Kalenda Development Award Joe Carter Cyr Robert Oscar Kan Marjorie L. Clary Carter and Donald Chad Kenneth Uptigrove Robert W. Parry Scholarship Richard N. Loeppky Joe Carter Edwin Vedejs Karen W. Morse and Joseph Grant Cecil Robert Lubitz Estate of Seyhan N. Ege Jamie Allen Wiersema Morse Calvin Roman Messing Gerald David Fong and Day-Lih Tung William Koon Chong Wong and Jea- Bonnie Pauly Paine and Robert Treat Judith Ann Pointer and Roy Dewain Rebecca Jo Parker and David Ralph nette Lee Wong Paine Pointer Parker Steven R. Zawacky and Susan K.S. Joanne and Jerry Robertson Fund at Univ. of Michigan and Peking Peter A.S. Smith Fellowship Gulf Coast Community Foundation Zawacky Univ. Student Exchange Reuben L. Baumgarten and Iris M. Dorothy E. Rowe and Charles David Pfizer, Incorporated Chemistry, Pres Challenge for Baumgarten Rowe Grad Support William Lee Berry and Jean C. Berry Joseph Glenn Wirth and Michael M. Werner E. Bachmann Memorial Irving M. Adler and Frances L. Adler John Joseph Callahan and Rosemary J. Wirth Lecture Fund William F. Bradford and Beth V. Callahan Frederick L. Crane and Marilyn A. Bradford Shang-Shing Peter Chou Pfizer Undergrad. Summer Fel- Crane E. John Duguid Roxanne M. Drnevich and Vincent Paul lowship in Organic Chemistry Robert A. Gregg Revocable Trust J. M. Lagowski and Jeanne M. Drnevich Pfizer International Inc. Lagowski Harry Alfred Dugger and Elisabeth Robert & Carolyn Buzzard Other Support Dugger Dow Chemical Company Foundation H. H. Willard Memorial Grad Chem Student Leadership David W. Emerson and Shirley A. GMA Cover Corp. Graham Deuer Stewart Robert A. Buzzard and Carolyn Buz- Emerson Novartis Corp. zard Howard T. & Virginia M. Siefen Simon Frank and Yakira Hagalili Frank Pfizer Int, Inc. Chemistry Fellowship GE Foundation 3M Company Howard T. Siefen Estate

Alumni News E-Mail your news: [email protected] Update your contact information: http://www.umich.edu/~michchem/alumni/ If errors or misstatements are noted in any of the following items, the Editors of the Newsletter would appreciate such being called to their attention. Mistakes can and do, inadvertently, creep in. Corrections can easily be inserted in the next edition.

Saleem A. Al-Ahmad (PhD 1990, Dimitri Frank J. Derbyshire Professor of Chemistry families in Ann Arbor in August 27-29. Coucouvanis) has been promoted to Man- and the Chairman of the Department of The group included Kartar Arora (PhD aging Director at Lubrizol Transarabian Chemistry at UK. 1984) and Richard Tomko (PhD 1982). Co. Ltd in Jeddah, Saudi Arabia. In August Lowell O. Bird (BS 1954, MBA 1958) We visited the Chemistry Building (Mark he visited Ann Arbor with his daughters is retired from Goodyear Tire Company. Meyerhoff gave us a wonderful tour on Sat- Reem and Mayada. He writes that in 2008-9 he was offered urday morning), went to the annual Macro Peter (PJ) Alaimo (BS 1994, PhD 1999 and accepted a temporary position in a picnic in Gallup park, and toured around UC Berkeley) has been promoted to As- chemical engineering laboratory. The job campus and some of our favorite spots in sociate Professor with tenure at Seattle involved nanofibers which had not even town, including dinner at the Cottage Inn. University, WA. been dreamed about in 1954. He found the Norman P. Arends (BS 1967) writes job exhilarating. But he observed that his that he is happily retired in the Brittany coworkers had trouble comprehending that region of France. he had graduated more than 54 years earlier. Leonidas Bachas (PhD 1986, Mark Kerryn Brandt (PhD 1984, Charles Over- Meyerhoff) became Dean of the College berger) is now at Dow Chemical Co. since of Arts and Sciences at the University their acquisition of Rohm and Haas last of Miami (Coral Gables, FL) in July. year. He and his wife Laura have a daughter Dr. Bachas had previously been on the Carolyn who just started her senior year faculty of the University of Kentucky of high school. Kerryn writes,” that three Kartar Arora, Kerryn Brant, Betty Over- (1986-2010). Most recently he was the Overberger PhD’s got together with their berger and Richard Tomko

U-M DEPARTMENT OF CHEMISTRY 11 Most importantly, Betty Overberger hosted her time travelling and living in both the Nick Preketes (BS 2008) has been received us for a brunch on Sunday. She would south of France and southern California. a NSF Graduate Fellowship. He is attend- love to see more former Overberger group Neil Law (PhD 1999, Vincent Pecoraro) is a ing UC Irvine. members.” faculty member at St. Lawrence University, Douglas J. Raber (PhD 1968, Richard Brian Brennan (BS 2003, PhD 2007, NY. He recently spent a sabbatical leave Lawton) was honored as a 2010 ACS Anna Mapp) is an Assistant Professor of working in Professor Pecoraro’s laboratory. Fellow. He writes about his recent activi- Chemistry at Illinois Wesleyan University. Richard N. Loeppky (PhD 1963, Peter ties,” After leaving the National Research Richard J. Cook (BS 1969, PhD 1973 Smith) has received the Founders Award Council in 2003, I spent several years as Princeton) retired as president of Allegheny from the Division of Chemical Toxicology a science-policy consultant, doing studies College in July 2008 after twelve years in of the ACS at its meeting in Boston in Au- and writing reports for non-profits such that office. Allegheny College awarded gust 2010. He was also in the inaugural as the ACS and the Chemical Heritage him the Alumni Metal, honorary Alumnus class of ACS Fellows in 2009. Professor Foundation. Then, an interesting twist Status and the degree of Doctor of Humane Loeppky retired from a professorship at began. My wife Linda (a longtime editor Letters, Honoris Causa. He is currently a the University of Missouri after 40 years of at Chemical and Engineering News) had presidential fellow with Second Nature and service. He now resides in the Seattle area. developed an idea for a novel about bioter- an independent consultant in leadership. rorism. But her day job didn’t leave much Justin Lomont (BS 2009) has been time to write, so she asked me to draft a David W. Emerson (PhD 1958, Peter awarded an NSF Graduate Fellowship. chapter for her to edit. She liked the re- Smith) is now a Professor of Chemistry He is attending UC Berkeley where he is sults, and we’re now on the third book of Emeritus at the University of Nevada at working with Professor Charles Harris. collaboration (all in the ‘thriller-terrorism’ Las Vegas. He remains active in research James MacKay (PhD 2004, Edwin Vedejs) genre with underlying science themes). I and continues to mentor undergraduates was an American Cancer Society postdoc- use the word ’book’ advisedly, however, in research projects. In 2009 he received toral fellow with Professor Viresh Rawal at since this is said to be the worst time in the Donna Weistrop Career Achievement the University of Chicago. Since 2007 he recorded history to break into fiction as a Award in the UNLV College of Sciences. has been an Assistant Professor at Eliza- new author. Getting something published Amelia Fuller (PhD 2006, Anna Mapp) bethtown College in Elizabethtown, PA. in the fiction arena is a whole lot more is currently Clare Boothe Luce Assistant difficult than anything I ever experienced Katie R. Mitchell-Koch (MS 2005, PhD Professor at Santa Clara University, Santa in chemistry. Nevertheless, it has been 2008 U. Kansas) has been teaching part- Clara, CA. She was recently awarded an entirely enjoyable experience, and we time and doing postdoctoral research at Em- a Research Innovation Award from the shall persevere.” poria State University, Emporia, KS. She Research Corporation and a Camille and and her husband Jeremy have a daughter Lidaris San Miguel Rivera (PhD 2008, Henry Dreyfus Foundation Faculty Start- Molly Rachel who was born in May 2008. Adam Matzger) and Adam Grzesiak (PhD up Award. 2007, Adam Matzger) are both at the Dow Christine Morrison (BS 2010) has been John Gladysz (BS 1971, PhD 1974 Stan- Chemical Company in Midland, MI. They awarded a Fulbright Fellowship which has ford) has been appointed Editor in Chief of had a son last year and are now expecting allowed her to do research at the Karlsruhe the ACS journal Organometallics. the birth of their second child. University (Germany). Kerry W. Hipps (Postdoctoral 1977-79, Todd Senecal (BS 2006) is a chemistry She has also been awarded an NSF Graduate Anthony Francis) is a Professor of Chem- graduate student at MIT where he is work- Fellowship and expects to enroll at the Cali- istry and Material Science at Washington ing with Professor Stephen Buchwald. He fornia Institute of Technology next year. State University. He was recently named recently published his first graduate paper as a 2010 ACS Fellow. Thomas J. Pacansky (PhD 1972, Charles in Science. Overberger) has been named a 2010 ACS Morton Z. Hoffman (PhD 1960, Richard Jim Tchobanoff (BS 1968, MA (Library Fellow and a 2010 ACS Polymer Divi- Bernstein) was elected to the inaugural Science) 1971) was recently awarded the sion Founding Fellow. He had previously group (2009) of Fellows of the American 2010 John Cotton Dana Award by the received an ACS Polymer Division Dis- Chemical Society. He is a Professor Emeri- Special Library Association. The award tinguished Service Award in 2005. Tom tus of Chemistry at Boston University. He is recognizes a lifetime of exceptional service has served as a scientist and high-level also a Fellow for the American Association to the information profession. Jim worked technology manager with Xerox and Exxon for the Advancement of Science (AAAS). for the Pillsbury Company for 24 years. Mobil. He is now the President of Appollo Professor Hoffman serves as a Councilor He currently runs an independent library Ventures, LLC in Watchung, NJ. for the Northeastern Section of the ACS and and management consulting business in has been Chair of the Division of Chemical Jun Pan (PhD 2007, Arthur Ashe) is now Arden Hills, MN. Education of the ACS. a postdoctoral fellow at MIT where he is James Zimmerman (PhD 1999, Henry working with Professor Stephen Buchwald. Elizabeth Irwin (MS 1967, MD 1979 Griffin) has been appointed as the Direc- UCLA) worked at UCLA in mass spectros- Jason K. Pontrello (BS 1998, PhD U. tor of the Christian A. Johnson Institute copy prior to attending medical school. She Wisconsin) is currently an Assistant Profes- for Effective Teaching at Rollins College, had a private practice in OB/GYN before sor of Chemistry at Brandeis University in Winter Park, FL. her retirement in 2007. She now spends Waltham, MA.

12 2010 In Memoriam We are saddened to announce the deaths of the following faculty, alumni, alumnae and friends of the Department.

Howard M. Dess (PhD 1955, Robert Parry) 1964. In 1966 he became the first recipient part of the Manhattan project. He recalled died in New York, NY on June 6, 2010 at the of the Eisenhart Award for Distinguished years later that they were only allowed age of 81. Dr. Dess was born in Chicago Young Teachers. Professor Gilman served to refer to the uranium as X-metal. He and earned a BS in chemistry from Indiana as the head of the Chemistry Department was employed in Cleveland until 1949, University in 1951. After receiving his PhD 1972-79. In 1970 and again in 1980 he was when he was transferred to LaPorte, TX. in inorganic chemistry with Parry, he was a visiting scholar at UCLA where he worked He observed that his job involved more employed as a research chemist with the in the laboratory of Professor Donald Cram. chemical engineering than chemistry. He Electrometal Company, Pennsalt Chemical He retired from RIT in 1994 and subsequently retired from DuPont in 1982. Dr. Siefen Corporation and Union Carbide Corporation. moved to Los Angles. He was interested in and his wife have generously left a bequest At Union Carbide he became a director of music and served on the board of the Opera to the University to establish the Howard research within the Metallurgical and the League of Los Angeles and as Controller of T. and Virginia M. Siefen Chemistry Fel- Linde Divisions. He was an expert on crystal the Long Beach Opera. lowship Fund. growth. In 1986 he earned a masters degree in Annabel Muenter (BS 1966, Dunn, PhD Clark G. Spike (PhD 1953, Robert Parry) library science from Rutgers University (New 1972, Harvard) passed away on May 17, 2010 died in Manchester, MI on May 7, 2010 at Brunswick, NJ). He became a Professor of at the age of 65. After receiving her PhD she the age of 88. Dr. Spike graduated with BS Library Science at Rutgers and ultimately on moved to Rochester ,NY where she worked from Michigan State Normal College (now his retirement Professor Emeritus of Library for 35 years as a Photographic Scientist for Eastern Michigan University) in 1944. After Science. He is survived by his wife Irene, the Eastman Kodak Company. She leaves obtaining his PhD in Inorganic Chemistry two sons, a daughter and three grandchildren. her husband John, daughter Annabel Edwards with Parry, he was employed as a research Robert E. Gilman (PhD 1958, Robert Elder- and a grandson, Corey. chemist with the Ethyl Corporation, 1952-58. He joined Eastern Michigan University as an field) died on February 2, 2010 at the age of Howard T. Siefen (BS 1940, PhD 1944, Associate Professor of Chemistry in 1958 78. Dr. Gilman obtained a BS from Dartmouth Werner Bachmann) died on August 22, and was promoted to full Professor in 1961. College and his PhD in organic chemistry at 2009. Dr. Siefen was a 1936 graduate of At EMU Professor Clark served as Depart- Michigan. He then worked for WR Grace Jackson (MI) High School. He attended ment Head 1961-1977, Interim Dean of the in Clarksville, MD and as a postdoctoral fel- Jackson Junior College for two years before College of Arts & Sciences 1977-79 and as low from 1960-62 at the National Research transferring to the University. In December Acting Associate Vice President for Academic Council of Canada in Ottawa. He also taught of 1943 he joined the DuPont Company Affairs 1979-80. On his retirement in 1983 at Williams College in Williamstown, MA where he would spend the next 34 years. he became Professor Emeritus of Chemistry. prior to joining the faculty of the Rochester One of his initial projects at DuPont was Institute of Technology (Rochester, NY) in

The Robert C. Taylor Fund chemistry majors. As associate chair he questions about making a gift or would like assigned all graduate student instructors additional information about the Robert C. September 27, 2011 will mark the tenth and processed fellowship and research Taylor Fund, please contact Diane Tracy in anniversary of Bob Taylor’s death. In assistant appointments. Over these years the LSA Development Office at 734-615- order to commemorate Bob’s many con- he came to know virtually every student 6761 or [email protected]. tributions to the Chemistry Department, in the Department. [A complete obituary a group of his friends and former students was published in the 2001-02 Chemistry have established the Robert C. Taylor Newsletter which may be found at the Fund, an endowment for graduate student Departmental website. http:www.umich. support in the Chemistry Department at edu/~michchem/alumni] the University. The Robert C. Taylor Fund constitutes Bob Taylor joined the faculty of the a gift for endowment, and distributions Chemistry Department in 1949, where he from it shall be made in accordance with served until his retirement in 1987. From the University’s then existing endowment 1967-1986 he was associate chairman, distribution policy. If you would like to working with three successive chairs. support this fund, you may do so checking During this time he regularly taught the the appropriate box on the attached gift physical chemistry course required of all card and returning it to us. If you have any

U-M DEPARTMENT OF CHEMISTRY 13 Faculty Amy Gottfried, Lecturer III. Kathleen V. Nolta, Lecturer IV. Organic Bio- Kristina Hakansson, Associate Professor of chemistry. Chemistry. Analytical Chemistry. Vincent L. Pecoraro, John T. Groves Collegiate Hashim M. Al-Hashimi, Professor of Chemistry; Robert T. Kennedy, Hobart H. Willard Collegiate Professor of Chemistry. Synthetic Inorganic Professor, Biophysics. Chemical Biology. Professor of Chemistry; Professor, Pharmacol- and Bioinorganic Chemistry. Philip Andrews, Professor of Biological Chemis- ogy. Analytical Chemistry. James E. Penner-Hahn, Professor of Chemis- try, Chemistry, Comp Med & Biology, Medical Nancy K. Kerner, Lecturer IV. Chemical Edu- try; Professor, Biophysics. Associate Dean, School and Director MLSC-Core Tech Alliance cation, Learning and Instructional Methods. LSA. Biophysical Chemistry and Inorganic Proteomics Center. Bioanalytical Chemistry Raoul Kopelman, Richard Smalley University Spectroscopy. Mark M. Banaszak Holl, Professor of Chemistry; Professor of Chemistry; Professor, Biomedical A. Ramamoorthy, Professor of Chemistry; Asso- Professor, Macromolecular Science & Engi- Engineering; Professor, Physics. Analytical/ ciate Professor, Biophysics. Structural Studies neering. Synthetic and Mechanistic Solution, Physical/Biophysical Chemistry. of Biological Molecules. Surface, and Solid State Chemistry. Masato Koreeda, Professor of Chemistry; Profes- Brandon Routolo, Assistant Professor of Chem- Bart M. Bartlett, Assistant Professor of Chemistry sor, Medicinal Chemistry. Synthesis of Natural istry, Analytical Chemistry. Inorganic, Materials Chemistry. Products, Small Molecule-DNA Interaction, Melanie Sanford, Professsor of Chemistry, Or- Julie S. Biteen, Assistant Professor of Chemistry. Chemical Carcinogenesis, Glycobiology. ganometallic Chemistry. Physical and Biophysical Chemistry Kevin Kubarych, Assistant Professor of Chem- Roseanne J. Sension, Professor of Chemistry; Charles L. Brooks III, Warner-Lambert/Parke- istry. Physical and Biophysical Chemistry Professor, Physics. Physical Chemistry, Ul- Davis Professor of Chemistry and Biophysics, Kenichi Kuroda, Assistant Professor of Dentistry, trafast Laser Spectroscopy. Physical Chemistry/Biophysical Chemistry/ Biologic & Materials Sciences, Biomedical David H. Sherman, Hans W. Vahlteich Professor Theoretical and Computational Chemistry Engr., and Chemistry. Physical Chemistry of Medicinal Chemistry; Professor, Microbiol- and Biophysics. Nicolai Lehnert, Dow Corning Assistant Pro- ogy and Immunology; Professor, Chemistry; Heather A. Carlson, Associate Professor of fessor. Bioinorganic Chemistry, Physical Research Professor, Life Sciences Institute. Medicinal Chemistry; Associate Professor, Inorganic Chemistry Medicinal Chemistry Chemistry, Computational Chemistry, Drug Mi Hee Lim, Assistant Professor of Chemistry; Jadwiga Sipowska, Lecturer IV. General Design, Theoretical Biophysics Research Assistant Professor, Life Sciences Chemistry Mary Anne Carroll, Professor of Atmospheric, Institute. Bioinorganic, Medicinal Chemistry, Nathaniel Szymczak, Assistant Professor Oceanic and Space Sciences; Professor, Chem- Chemical Biology. of Chemistry. Energy Science, Inorganic istry. Atmospheric Chemistry. David M. Lubman, Maude T Lane Professor Chemistry Zhan Chen, Professor of Chemistry; Professor, of Surgical Immunology; Professor, Surgery; Edwin Vedejs, Moses Gomberg Collegiate Profes- Macromolecular Science & Engineering. Pathology; Professor, Chemistry. Biological sor of Chemistry. Organic Chemistry. Biomaterial and Polymer Surface, Biocom- Mass Spectrometry, Spectroscopy and Instru- Nils G. Walter, Professor of Chemistry; Associ- patibility. mentation. ate Research Scientist, Biophysics Research Mary Sue Coleman, UM President and Professor Stephen Maldonado, Assistant Professor of Division. Chemical Biology. of Chemistry Chemistry Electrochemistry, Materials John P. Wolfe, Professor of Chemistry. Organo- Brian P. Coppola, Arthur F. Thurnau Professor of Chemistry. metallic Chemistry. Chemistry; Associate Chair for Undergraduate Anna K. Mapp, Professor of Chemistry; Profes- Ronald W. Woodard, Professor and Chair of Chemistry. Organic Chemistry. Science Learn- sor, Medicinal Chemistry. Organic Chemistry, Medicinal Chemistry; Professor, Chemistry. ing and Instructional Methods. Chemical Biology, New Synthetic Methods. Medicinal Chemistry. Barry Dunietz, Assistant Professor of Chemistry. E. Neil G. Marsh, Professor of Chemistry; Associ- Edward T. Zellers, Professor of Environmental Theoretical and Computational Chemistry ate Professor, Biological Chemistry. Chemical and Industrial Health; Professor, Chemistry Carol A. Fierke, Chair. Jerome and Isabella Karle Biology, Enzymes, Structure, Mechanism and Environmental-Analytical Chemistry. Collegiate Professor of Chemistry; Professor, Specificity; Protein Engineering and Molecular Biological Chemistry. Chemical Biology, Recognition. Bioinorganic Chemistry. Adam J. Matzger, Professor of Chemistry; Profes- Professors Emeriti: Arthur J. Ashe III, Anthony H. Francis, Arthur F. Thurnau Professor sor, Macromolecular Science & Engineering. Lawrence S. Bartell, S.M. Blinder, Dimitri of Chemistry; Associate Dean, LS&A. Mag- Organic, Polymers/Organic Materials. Coucouvanis, James K. Coward, M. Da- netic Resonance, Vibrational and Electronic Anne J. McNeil, Assistant Professor of Chemistry. Spectroscopy of Materials. vid Curtis, Thomas M. Dunn, B.J. Evans, Polymer and Organic/Materials Chemistry, John L. Gland, Adon A. Gordus, Henry C. Eitan Geva, Professor of Chemistry. Theoretical Mark E. Meyerhoff, Philip J. Elving Collegiate Griffin, Robert L. Kuczkowski, Richard and Computational Chemistry. Professor. Bioanalytical Chemistry, Electro- G. Lawton, Lawrence L. Lohr, Daniel T. Gary D. Glick, Werner E. Bachmann Collegiate chemical and Optical Sensors. Longone, Joseph P. Marino, Christer E. Professor of Chemistry; Professor, Biological John Montgomery, Professor of Chemistry. Nordman, Paul G. Rasmussen, Robert Chemistry. Chemical Biology, Bioorganic Organic and Organometallic Chemistry R. Sharp, Peter A.S. Smith, Leroy B. Chemistry, Molecular Recognition. Michael D. Morris, Richard D. Sacks Collegiate Pro- Townsend, Edgar F. Westrum, Jr., John Theodore Goodson, III, Richard Barry Bernstein fessor of Chemistry. Analytical Laser Spectros- R. Wiseman, Charles F. Yocum Collegiate Professor of Chemistry; Professor, copy and Imaging; Electrophoretic Separations. Macromolecular Science & Engineering. Pavel Nagorny, Assistant Professor of Chemistry. Physical Chemistry Organic Chemistry

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