Chemistry N E W S L E T T E R
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B. Jill Venton, Ph.D
B. Jill Venton, Ph.D. P.O. Box 400319 phone: (434) 243-2132 Charlottesville, VA 22904-4319 email: [email protected] Positions and Employment Professor, University of Virginia, Charlottesville, VA 2016-present Associate Professor, University of Virginia, Charlottesville, VA 2011-2016 Assistant Professor, University of Virginia, Charlottesville, VA 2005-2011 Department of Chemistry and Neuroscience Graduate Program Research interests: Development of new carbon nanotube-based biosensors Electrochemical sensors for understanding adenosine signaling Measurements of neurotransmitters in Drosophila Rapid capillary electrophoresis for monitoring neurotransmitter changes Postdoctoral Researcher, University of Michigan, Ann Arbor, MI 2003-2005 Advisors: Robert Kennedy (Chemistry) and Terry Robinson (Psychology) Research: Rapid detection of amino acids changes during fear behavior using capillary electrophoresis Education Ph.D., Chemistry (Analytical), University of North Carolina, Chapel Hill, NC 2003 Advisor: Mark Wightman Dissertation: Electrochemical detection of chemical dynamics in the rat brain B.S., Chemistry, University of Delaware, Newark, DE 1998 Honors degree, summa cum laude Research Advisor: Murray Johnston Undergraduate thesis: Secondary structure of oligonucleotides probed by MALDI Awards and Fellowships Society for Electroanalytical Chemistry (SEAC) Young Investigator Award 2011 Camille Dreyfus Teacher-Scholar 2010 American Chemical Society PROGRESS/Dreyfus Foundation Lectureship 2008 Eli Lilly Young Analytical Investigator -
ORGANIC CHEMISTRY Alkynes
University of Michigan new functional groups. (3) Developing novel routes for functionalizing readily available organic building blocks DEPARTMENT OF CHEMISTRY such as alkenes and alkynes. (4) Exploring the reduc- tive coupling of aldehydes and alkynes or enones and ORGANIC CHEMISTRY alkynes. Recent studies have demonstrated strategies involving redox isomerization to avoid the use of reduc- Graduate Program ing agents in processes of this type. (5) The discovery of new glycosylation methods and their application in collaborative projects involving enzymatic C-H oxida- tion reactions. Traditional Synthetic Novel C–H Bond Approach Functionalization Approach Fluorinated amino acids can be used to make super-stable “Tef- O O N O NH N lon” proteins; here the interior of a small protein is packed with the Michigan offers a diverse selection of research oppor- 2 Br 1. Br cat. PdII fluorous amino acid hexafluoroleucine (Marsh). O N tunities in Organic Chemistry with particular strengths Y Y Y N 2. NH3/MeOH Oxidant–X in Organometallic Chemistry, Organic Synthesis, Bioor- X X H 3. CH3I ganic Chemistry, and Organic Materials. Our innovative treatment of autoimmune diseases and cancer. (3) Anti-anxiety research rotation program allows students to explore Anti-convulsant Developing and applying chemical tools to study a range of exciting possibilities before choosing an Palladium-catalyzed C-H functionalization of an arene (Sanford). the role of oxidants as signaling molecules and the advisor. Specific research projects in each area are biological basis of aging. (4) Elucidating catalytic highlighted below. mechanisms and essential active site features of me- talloenzymes and ribozymes, including protein farnes- Organic Synthesis yltransferase, UDP-3-O-acyl-GlcNAC deacetylase, his- R3 H tone deacetylase and ribonuclease P. -
Annual Report 2013.Pdf
ATOMIC HERITAGE FOUNDATION Preserving & Interpreting Manhattan Project History & Legacy preserving history ANNUAL REPORT 2013 WHY WE SHOULD PRESERVE THE MANHATTAN PROJECT “The factories and bombs that Manhattan Project scientists, engineers, and workers built were physical objects that depended for their operation on physics, chemistry, metallurgy, and other nat- ural sciences, but their social reality - their meaning, if you will - was human, social, political....We preserve what we value of the physical past because it specifically embodies our social past....When we lose parts of our physical past, we lose parts of our common social past as well.” “The new knowledge of nuclear energy has undoubtedly limited national sovereignty and scaled down the destructiveness of war. If that’s not a good enough reason to work for and contribute to the Manhattan Project’s historic preservation, what would be? It’s certainly good enough for me.” ~Richard Rhodes, “Why We Should Preserve the Manhattan Project,” Bulletin of the Atomic Scientists, May/June 2006 Photographs clockwise from top: J. Robert Oppenheimer, General Leslie R. Groves pinning an award on Enrico Fermi, Leona Woods Marshall, the Alpha Racetrack at the Y-12 Plant, and the Bethe House on Bathtub Row. Front cover: A Bruggeman Ranch property. Back cover: Bronze statues by Susanne Vertel of J. Robert Oppenheimer and General Leslie Groves at Los Alamos. Table of Contents BOARD MEMBERS & ADVISORY COMMITTEE........3 Cindy Kelly, Dorothy and Clay Per- Letter from the President..........................................4 -
2006Spring.Pdf
− X8 PROTEUM THE ULTIMATE STRUCTURAL BIOLOGY SYSTEM When you need the best system for Structural Biology, the Bruker X8 PROTEUM offers high-throughput screening AND superb high resolution data in one uncompromising package. With our MICROSTAR family of generators, you can rely on the extremely intense micro-focus X-ray beam coupled with the ultra-bright HELIOS optics to handle everything from small crystals to large unit cells With over 700135 detector CCD detectors for speed, installed, sensitivity, we know size and how dynamic to optimize range the to give PLATINUM you the best data possible in the home lab Our KAPPA goniometer’s high precision mechanics allow you to orient the sample along any axis in reciprocal space, while having easy access to mount, cool or anneal your crystals Get the best data, get the fastest system, get the power to solve your structures – X8 PROTEUM. BRUKER ADVANCED X-RAY SOLUTIONS North America: BRUKER AXS INC Tel. (+1) (608) 276-3000 Fax (+1) (608) 276-3006 www.bruker-axs.com [email protected] Germany: BRUKER AXS GMBH Tel. (+49) (721) 595- 2888 Fax (+49) (721) 595-4587 www.bruker-axs.de [email protected] Netherlands: BRUKER AXS BV Tel. (+31) (15) 215-2400 Fax (+31) (15) 215-2500 www.bruker-axs.nl [email protected] American Crystallographic Association * REFLECTIONS *see page 9 for notes on our new name and for new logo possibilities Cover: Images from Warren Award Recipient Charles Majkrazk and his colleagues; see page 25. ACA HOME PAGE: hwi.buffalo.edu/ACA/ Table of Contents 3 President’s -
Profound Neuronal Plasticity in Response to Inactivation of the Dopamine Transporter
Proc. Natl. Acad. Sci. USA Vol. 95, pp. 4029–4034, March 1998 Neurobiology Profound neuronal plasticity in response to inactivation of the dopamine transporter SARA R. JONES*, RAUL R. GAINETDINOV*, MOHAMED JABER*†,BRUNO GIROS*‡,R.MARK WIGHTMAN§, AND MARC G. CARON*¶ *Howard Hughes Medical Institute Laboratories, Department of Cell Biology and Medicine, Duke University Medical Center, Durham, NC 27710; and §Department of Chemistry and Curriculum in Neurobiology, University of North Carolina, Chapel Hill, NC 27599 Edited by P. S. Goldman-Rakic, Yale University School of Medicine, New Haven, CT, and approved January 2, 1998 (received for review October 13, 1997) ABSTRACT The dopamine transporter (DAT) plays an ine the importance of the DAT, we created a strain of mice important role in calibrating the duration and intensity of lacking the dopamine tranporter protein using homologous dopamine neurotransmission in the central nervous system. recombination (11). The most obvious phenotype of these We have used a strain of mice in which the gene for the DAT genetically modified animals is their marked spontaneous has been genetically deleted to identify the DAT’s homeostatic hyperlocomotion, which is similar to animals on high doses of role. We find that removal of the DAT dramatically prolongs psychostimulants. In this work, we examine the underlying the lifetime (300 times) of extracellular dopamine. Within the biochemical changes that accompany this genetic alteration. time frame of neurotransmission, no other processes besides Although the contribution of the DAT to the dynamics of diffusion can compensate for the lack of the DAT, and the dopamine in the extracellular space is well appreciated, this absence of the DAT produces extensive adaptive changes to work reveals the central role of the DAT in the regulation of control dopamine neurotransmission. -
Document 4. Memòria D'activitats 2019
MEMÒRIA D’ACTIVITATS FUNDACIÓ INSTITUT CATALÀ D’INVESTIGACIÓ QUÍMICA ANY 2019 Memòria d’Activitats ICIQ 2019 2 Memòria d’Activitats ICIQ 2019 Sumari 1. L’Institut – visió general ......................................................................................................... 5 2. Governança i organització ..................................................................................................... 6 2.1. Governança .............................................................................................................. 6 2.2. Organització ............................................................................................................. 8 2.3. Àrea de Recerca ..................................................................................................... 11 3. Recursos humans ................................................................................................................. 16 3.1. Pla de formació ...................................................................................................... 18 4. Resultats de recerca ............................................................................................................ 21 4.1. Publicacions científiques ........................................................................................ 21 4.1.1. Anàlisi bibliomètric .................................................................................. 21 4.1.2. Publicacions en portades o contraportades de revistes ......................... 26 4.2. Recerca destacada ................................................................................................ -
ACA Structure Matters, Winter 2017
ACA Isabella Karle (1921-2017) Winter 2017 Structure Matters Remembering Isabella Karle “I need to tackle this scientific problem, what techniques are Isabella Karle (1921 - 2017), retired from the Naval Research available to help me do it?” and when she found out what they Laboratory (Washington, DC) after more than six decades there, were she would solve the problem. In this case she worked with passed away on October 3, 2017, at the age of 95, from a brain silica tubes that she had made, filled with crude plutonium oxide tumor. Early on Isabella was told by a teacher that chemistry and chemical reactants, and inserted them in a hole in a large was not a “proper field for girls” but she went on to become a block of copper that was heated to high temperatures of 800 to member of the National Academy of Sciences. She received the 900 degrees Centigrade. After many experiments under difficult 1988 Gregori Aminoff Prize from the Royal Swedish Academy conditions, she ended up, triumphantly, with bright green crystals of plutonium chloride (PuCl ) that she passed on to the physics of Sciences, the 1993 Bower Award and Prize for Achievement 3 in Science and, in 1995, received the National Medal of Science. branch of the Manhattan project. What follows are remembrances from several of her colleagues. Isabella approached direct methods in the same way, to the delight of her husband Jerry, who won the Nobel Prize for his work on them. She worked hard to find how to run direct methods correctly and then was able to help others. -
70Th Anniversary of the Manhattan Project Atomic Heritage Foundation
Atomic Heritage Foundation presents 70th Anniversary of the Manhattan Project June 2 and 3, 2015 Carnegie Institution for Science 1530 P Street, NW Washington, DC 20005 Visit our merchandise tables to purchase books, posters, and hats! Manhattan Project 70th Anniversary Manhattan Project veterans Lawrence S. O’Rourke (left) and William E. Tewes (right) with his future wife, Olive. The Atomic Heritage Foundation is proud to host events commemorating the 70th Anniversary of the Manhattan Project. It took more than half a million people to build the world’s first atomic bombs; we are honored to welcome more than a dozen men and women who participated in that astonishing effort. The 70th Anniversary Reunion on June 2 will be an opportunity for vet- erans and family members to share their memories and catch up with old friends. Veterans from Los Alamos, Oak Ridge, Hanford, Chicago and other locations will discuss how each site contributed to the Manhattan Project in its own unique way. The 70th Anniversary commemoration will continue on June 3 with a day- long symposium, which will feature a discussion of the new Manhattan Project National Historical Park. We have assembled a first-class roster of Manhattan Project veterans and experts who will discuss topics ranging from innovation to women in science to atomic spies and more. We hope you enjoy the events! Cynthia C. Kelly President, Atomic Heritage Foundation Atomic Heritage Foundation The Atomic Heritage Foundation (AHF), founded by Cynthia C. Kelly in 2002, is a nonprofit organization in Washington, DC, dedicated to the preservation and interpretation of the Manhattan Project and its legacy. -
SCIENCE HISTORY INSTITUTE ISABELLA KARLE and JEROME
SCIENCE HISTORY INSTITUTE ISABELLA KARLE and JEROME KARLE Transcript of an Interview Conducted by James J. Bohning and David K. Van Keuren at Naval Research Laboratory Washington, District of Columbia on 26 February, 15 June and 9 September 1987 (With Subsequent Corrections and Additions) Upon Isabella Karle’s death in 2017, this oral history was designated Free Access. Please note: This oral history is protected by U.S. copyright law and shall not be reproduced or disseminated in any way without the express permission of the Science History Institute. Users citing this interview for purposes of publication are obliged under the terms of the Center for Oral History, Science History Institute, to credit the Science History Institute using the format below: Isabella Karle and Jerome Karle, interview by James J. Bohning and David K. Van Keuren at Naval Research Laboratory, Washington, District of Columbia, 26 February, 15 June and 9 September 1987 (Philadelphia: Science History Institute, Oral History Transcript # 0066). Formed by the merger of the Chemical Heritage Foundation and the Life Sciences Foundation, the Science History Institute collects and shares the stories of innovators and of discoveries that shape our lives. We preserve and interpret the history of chemistry, chemical engineering, and the life sciences. Headquartered in Philadelphia, with offices in California and Europe, the Institute houses an archive and a library for historians and researchers, a fellowship program for visiting scholars from around the globe, a community of researchers who examine historical and contemporary issues, and an acclaimed museum that is free and open to the public. For more information visit sciencehistory.org. -
Calendario De Mujeres Científicas Y Maestras
Mil Jardines Ciencia y Tecnología Calendario de Mujeres Científicas y Maestras Hipatia [Jules Maurice Gaspard (1862–1919)] Por Antonio Clemente Colino Pérez [Contacto: [email protected]] CIENCIA Y TECNOLOGÍA Mil Jardines . - Calendario de Mujeres Científicas y Maestras - . 1 – ENERO Marie-Louise Lachapelle (Francia, 1769-1821), jefe de obstetricia en el Hôtel-Dieu de París, el hospital más antiguo de París. Publicó libros sobre la anatomía de la mujer, ginecología y obstetricia. Contraria al uso de fórceps, escribió Pratique des accouchements, y promovió los partos naturales. https://translate.google.es/translate?hl=es&sl=ca&u=https://ca.wikipedia.org/wiki/Marie-Louise_Lachapelle&prev=search Jane Haldiman Marcet (Londres, 1769-1858), divulgadora científica que escribió sobre química, enero 1 botánica, religión, economía y gramática. Publicó Conversations on Chemistry, con seudónimo masculino en 1805, pero no fue descubierta su autoría hasta 1837. https://lacienciaseacercaalcole.wordpress.com/2017/01/23/chicas-de-calendario-enero-primera-parte/ https://mujeresconciencia.com/2015/08/19/michael-faraday-y-jane-marcet-la-asimov-del-xix/ Montserrat Soliva Torrentó (Lérida, 1943-2019), doctora en ciencias químicas. https://es.wikipedia.org/wiki/Montserrat_Soliva_Torrent%C3%B3 Florence Lawrence (Canadá, 1886-1938), actriz del cine mudo apasionada por los coches, que inventó el intermitente, pero no lo consideró como propio y pasó el final de sus días sola y arruinada. https://www.motorpasion.com/espaciotoyota/el-dia-que-una-mujer-invento-el-intermitente-y-la-luz-de-freno-para-acabar-despues- arruinada Tewhida Ben Sheikh (Túnez, 1909-2010), primera mujer musulmana en convertirse en medica y llegó a plantear temas como la planificación familiar, la anticoncepción y el aborto en su época, en el norte enero 2 de Africa. -
Serotonin) Neuronal Release and Uptake: an Investigation of Extrasynaptic Transmission
The Journal of Neuroscience, July 1, 1998, 18(13):4854–4860 Quantitative Evaluation of 5-Hydroxytryptamine (Serotonin) Neuronal Release and Uptake: An Investigation of Extrasynaptic Transmission Melissa A. Bunin and R. Mark Wightman Curriculum in Neurobiology and Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290 Whether neurotransmitters are restricted to the synaptic cleft tration of 5-HT released per stimulus pulse in both regions to be (participating only in hard-wired neurotransmission) or diffuse to identical when elicited by single pulse stimulations or trains at remote receptor sites (participating in what has been termed high frequency. 5-HT efflux elicited by a single stimulus pulse volume or paracrine transmission) depends on a number of was unaffected by uptake inhibition or receptor antagonism. factors. These include (1) the location of release sites with Thus, synaptic efflux is not restricted by binding to intrasynaptic respect to the receptors, (2) the number of molecules released, receptors or transporters. The number of 5-HT molecules re- (3) the diffusional rate away from the release site, determined by leased per terminal was estimated in the substantia nigra re- both the geometry near the release site as well as binding ticulata and was considerably less than the number of 5-HT interactions, and (4) the removal of transmitter by the relevant transporter and receptor sites, reinforcing the hypothesis that transporter. Fast-scan cyclic voltammetry allows for the detec- these sites are extrasynaptic. Furthermore, the detected extra- tion of extrasynaptic concentrations of many biogenic amines, synaptic concentrations closely match the affinity for the pre- permitting direct access to many of these parameters. -
SUMMARY of PERSONNEL ACTIONS REGENTS AGENDA June 2012
SUMMARY OF PERSONNEL ACTIONS REGENTS AGENDA June 2012 ANN ARBOR CAMPUS 1. Recommendations for approval of new appointments and promotions for regular associate and full professor ranks, with tenure. (1) Boehman, André L., professor of mechanical engineering, with tenure, College of Engineering, effective September 1, 2012. (2) Davenport, Christian, professor of political science, with tenure, College of Literature, Science, and the Arts, effective September 1, 2012. (3) Denton, Brian T., associate professor of industrial and operations engineering, with tenure, College of Engineering, effective September 1, 2012. (4) Fenstermaker, Sarah, professor of women’s studies, with tenure, College of Literature, Science, and the Arts, effective September 1, 2012. (5) Gold, David, associate professor of English language and literature, with tenure, College of Literature, Science, and the Arts, effective September 1, 2012. (6) Mihalcea, Rada F., associate professor of electrical engineering and computer science, with tenure, College of Engineering, effective September 1, 2013. (7) Neumar, Robert W., M.D., Ph.D., professor of emergency medicine, with tenure, effective July 1, 2012, and chair, Department of Emergency Medicine, Medical School, effective July 1, 2012 through June 30, 2017. (8) Ward, Brent B., promotion to associate professor of dentistry, with tenure, School of Dentistry, effective September 1, 2012 (currently assistant professor of dentistry.) 2. Recommendations for approval of new appointments and promotions for regular associate and full professor ranks, without tenure. (1) Abbott, Patricia, associate professor of nursing, without tenure, School of Nursing, effective September 1, 2012. 3. Recommendations for approval of reappointments of regular instructional staff and selected administrative/professional staff. (1) Appelman, Henry D., M.D., M.R.