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Caso Relativamente Recente
Perché chiamiamo “fondamentale” la Cenerentola della ricerca? (di M. Brunori) Neanche nel Pnrr si trovano speranze di cambiamento e iniziative coraggiose per la ricerca di base. Ma nelle scienze della vita non sono rare le scoperte nate da progetti di ricerca curiosity driven che richiedono tempo per portare risultati Soci dell'Accademia dei Lincei. (a cura di Maurizio Brunori, Prof. emerito di Chimica e Biochimica, Sapienza Università di Roma, Presidente emerito della Classe di Scienze FMN dell’Accademia dei Lincei) Nelle scienze della vita non sono infrequenti le scoperte innovative nate da progetti di ricerca di base, iniziati per cercare di comprendere qualche importante proprietà di un essere vivente, misteriosa ma ovviamente necessaria se è stata conservata nel corso dell’evoluzione. Questi progetti sono quelli che si iniziano per curiosità intellettuale, ma richiedono libertà di iniziativa, impegno pluriennale e molto coraggio in quanto di difficile soluzione. Un successo straordinario noto a molti è quello ottenuto dieci anni fa da due straordinarie ricercatrici, Emmanuelle Charpentier e Jennifer Doudna; che a dicembre hanno ricevuto dal Re di Svezia il Premio Nobel per la Chimica con la seguente motivazione: “for the development of a new method for genome editing”. Nel 2018 in occasione di una conferenza magistrale che la Charpentier tenne presso l’Accademia Nazionale dei Lincei, avevo pubblicato sul Blog di HuffPost un pezzo per commentare l’importanza della scoperta di CRISPR/Cas9, un kit molecolare taglia-e-cuci che consente di modificare con precisione ed efficacia senza precedenti il genoma di qualsiasi essere vivente: batteri, piante, animali, compreso l’uomo. NOBEL PRIZE Nobel Chimica Non era mai accaduto che due donne vincessero insieme il Premio Nobel. -
Itcontents 9..22
INTERNATIONAL TABLES FOR CRYSTALLOGRAPHY Volume F CRYSTALLOGRAPHY OF BIOLOGICAL MACROMOLECULES Edited by MICHAEL G. ROSSMANN AND EDDY ARNOLD Advisors and Advisory Board Advisors: J. Drenth, A. Liljas. Advisory Board: U. W. Arndt, E. N. Baker, S. C. Harrison, W. G. J. Hol, K. C. Holmes, L. N. Johnson, H. M. Berman, T. L. Blundell, M. Bolognesi, A. T. Brunger, C. E. Bugg, K. K. Kannan, S.-H. Kim, A. Klug, D. Moras, R. J. Read, R. Chandrasekaran, P. M. Colman, D. R. Davies, J. Deisenhofer, T. J. Richmond, G. E. Schulz, P. B. Sigler,² D. I. Stuart, T. Tsukihara, R. E. Dickerson, G. G. Dodson, H. Eklund, R. GiegeÂ,J.P.Glusker, M. Vijayan, A. Yonath. Contributing authors E. E. Abola: The Department of Molecular Biology, The Scripps Research W. Chiu: Verna and Marrs McLean Department of Biochemistry and Molecular Institute, La Jolla, CA 92037, USA. [24.1] Biology, Baylor College of Medicine, Houston, Texas 77030, USA. [19.2] P. D. Adams: The Howard Hughes Medical Institute and Department of Molecular J. C. Cole: Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA. CB2 1EZ, England. [22.4] [18.2, 25.2.3] M. L. Connolly: 1259 El Camino Real #184, Menlo Park, CA 94025, USA. F. H. Allen: Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge [22.1.2] CB2 1EZ, England. [22.4, 24.3] K. D. Cowtan: Department of Chemistry, University of York, York YO1 5DD, U. W. Arndt: Laboratory of Molecular Biology, Medical Research Council, Hills England. -
The 2016 Nobel Prize in Chemistry
Pure Appl. Chem. 2016; 88(10-11): 917–918 Editorial Hugh D. Burrows* and Richard M. Hartshorn* The 2016 Nobel Prize in Chemistry DOI 10.1515/pac-2016-2005 Keywords: Ben L. Feringa; Jean-Pierre Sauvage; J. Fraser Stoddart; Nobel Prize in Chemistry; 2016. Pure and Applied Chemistry warmly congratulates Jean-Pierre Sauvage (University of Strasbourg, France), Sir J. Fraser Stoddart (Northwestern University, Evanston, IL, USA), and Bernard (Ben) L. Feringa (Univer- sity of Groningen, the Netherlands) on their award of the 2016 Nobel Prize in Chemistry. The citation from the Royal Swedish Academy of Sciences states that the award is “for the design and synthesis of molecu- lar machines”. Their work encompasses a broad spectrum of Chemistry, from elegant synthetic studies of catenanes, rotaxanes and other formerly considered exotic molecules, through coordination chemistry, and electron transfer reactions, to molecular switches and rotors driven by light and other external sources. They have all participated actively in IUPAC endorsed meetings and conference series, including the IUPAC World Congress in Chemistry, IUPAC International Conferences on Organic Synthesis (ICOS), Physical Organic Chemistry (ICPOC), and Coordination Chemistry (ICCC), and IUPAC International Symposia on Macrocyclic Chemistry (ISMC), Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS), Novel Aromatic Compounds (ISNA), Carbohydrate Chemistry (ICS), the Chemistry of Natural Products ISCNP), and Photo- chemistry. Pure Appl. Chem. publishes collections of papers based upon authoritative lectures presented at such IUPAC endorsed events, in addition to IUPAC Recommendations, and Technical Reports. We are very pleased to highlight the following publications from these three Nobel Laureates that have been published in Pure and Applied Chemistry as a result of their involvement in these conferences. -
Chemical Synthesis
www.iupac2017.org Adriano D. Andricopulo Chairman of the IUPAC-2017 Organizing Committee Brazil: Key Figures and Facts • Brazil is Latin America's largest country (47% of the South America Continent) and the fifth largest country in the world • Population: 204 million people (the fifth most populous in the world ) • Language: Portuguese . Official currency: Brazilian Real (1.00 USD = R$ 3.12) • Brazil has the world’s ninth-largest economy and the largest in Latin America Brazil: Key Figures and Facts . São Paulo has the largest population, industrial complex, and economic production in Brazil . Population: 12 million people (45 million in SP state) . It is the largest city in South America, and the fifth largest in the world . São Paulo State is responsible for 40% of the Brazilian GDP . Climate: humid subtropical, temperatures in July: 12 and 22°C (54°F and 72°F) . Number of tourists in 2016: > 18 million WTC Events Center and Sheraton WTC Hotel are the most complete complex for events in Latin America Approximately 12,000 m² are available and divided into 60 flexible spaces Services: Parking Restaurants Banks Currency exchange Travel agency Pharmacies Hairdresser’s Stationery General Aspects - 9 Plenary Lectures, including 4 Noble Laureates - About 120 Sessions in 12 major themes - Several Keynote, Invited, Oral and Young Scientists Opening Ceremony Special Symposia Welcome Reception 3 Poster Sessions Half-day Social Program Gala Dinner Exhibition Plenary Lectures Sir J. Fraser Stoddart (Nobel Prize 2016) Department of Chemistry -
Cambridge's 92 Nobel Prize Winners Part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin
Cambridge's 92 Nobel Prize winners part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin By Cambridge News | Posted: January 18, 2016 By Adam Care The News has been rounding up all of Cambridge's 92 Nobel Laureates, celebrating over 100 years of scientific and social innovation. ADVERTISING In this installment we move from 1951 to 1974, a period which saw a host of dramatic breakthroughs, in biology, atomic science, the discovery of pulsars and theories of global trade. It's also a period which saw The Eagle pub come to national prominence and the appearance of the first female name in Cambridge University's long Nobel history. The Gender Pay Gap Sale! Shop Online to get 13.9% off From 8 - 11 March, get 13.9% off 1,000s of items, it highlights the pay gap between men & women in the UK. Shop the Gender Pay Gap Sale – now. Promoted by Oxfam 1. 1951 Ernest Walton, Trinity College: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei 2. 1951 John Cockcroft, St John's / Churchill Colleges: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei Walton and Cockcroft shared the 1951 physics prize after they famously 'split the atom' in Cambridge 1932, ushering in the nuclear age with their particle accelerator, the Cockcroft-Walton generator. In later years Walton returned to his native Ireland, as a fellow of Trinity College Dublin, while in 1951 Cockcroft became the first master of Churchill College, where he died 16 years later. 3. 1952 Archer Martin, Peterhouse: Nobel Prize in Chemistry, for developing partition chromatography 4. -
Nobel Laureates Endorse Joe Biden
Nobel Laureates endorse Joe Biden 81 American Nobel Laureates in Physics, Chemistry, and Medicine have signed this letter to express their support for former Vice President Joe Biden in the 2020 election for President of the United States. At no time in our nation’s history has there been a greater need for our leaders to appreciate the value of science in formulating public policy. During his long record of public service, Joe Biden has consistently demonstrated his willingness to listen to experts, his understanding of the value of international collaboration in research, and his respect for the contribution that immigrants make to the intellectual life of our country. As American citizens and as scientists, we wholeheartedly endorse Joe Biden for President. Name Category Prize Year Peter Agre Chemistry 2003 Sidney Altman Chemistry 1989 Frances H. Arnold Chemistry 2018 Paul Berg Chemistry 1980 Thomas R. Cech Chemistry 1989 Martin Chalfie Chemistry 2008 Elias James Corey Chemistry 1990 Joachim Frank Chemistry 2017 Walter Gilbert Chemistry 1980 John B. Goodenough Chemistry 2019 Alan Heeger Chemistry 2000 Dudley R. Herschbach Chemistry 1986 Roald Hoffmann Chemistry 1981 Brian K. Kobilka Chemistry 2012 Roger D. Kornberg Chemistry 2006 Robert J. Lefkowitz Chemistry 2012 Roderick MacKinnon Chemistry 2003 Paul L. Modrich Chemistry 2015 William E. Moerner Chemistry 2014 Mario J. Molina Chemistry 1995 Richard R. Schrock Chemistry 2005 K. Barry Sharpless Chemistry 2001 Sir James Fraser Stoddart Chemistry 2016 M. Stanley Whittingham Chemistry 2019 James P. Allison Medicine 2018 Richard Axel Medicine 2004 David Baltimore Medicine 1975 J. Michael Bishop Medicine 1989 Elizabeth H. Blackburn Medicine 2009 Michael S. -
Chemistry News
Fall 2015 Chemistry News Filling the Chemical Sciences Pipeline Future chemists are being recruited by the Department of Chemistry at every age from grade school children to postdoctoral scholars. Hands-on activities encourage girls to learn and explore their potential in science, technology, math and engineering. FEMMES, a UM student organization, organizes events for 4th-6th grade girls on campus and in afterschool programs. Chemistry faculty organized lab tours for students students newly admitted to the University of Michigan in the Summer Bridge program. afety glasses and gloves in place, Johana and a dozen other fourth grade Sgirls used pipettes to drip a creamy mixture into cups of liquid nitrogen, watching the drops freeze instantly into an ice cream treat. After the graduate students strained the tasty dots out of the cup, the girls were able to eat the Cass Technical High School students spent the summer doing result of their experiment. research as part of the UM Detroit Research Internship These girls were attending an all-day event at the UM Chemistry build- Summer Experience, D-RISE. They participated alongside the ing organized by FEMMES, Females Excelling More in Math, Engineering, UM graduate students in the Karle Symposium. and the Sciences. FEMMES aims to inspire young girls, encouraging them to consider their potential in science and math. Each event features hands-on activities led by volunteers. Chemistry’s undergraduates, graduate students, and faculty are very active in the Michigan chapter of FEMMES. On a recent Saturday, FEMMES brought 300 girls to campus from Detroit and area schools to participate in twenty different activities. -
Molecular Machines Series: Topics in Current Chemistry
springer.com T. Ross Kelly (Ed.) Molecular Machines Series: Topics in Current Chemistry This series presents critical reviews of the present position and future trends in modern chemical research. Short and concise reports on chemistry, each written by the world renowned experts. Still valid and useful after 5 or 10 years. More information as well as the electronic version of the whole content available at: springerlink.com The chapters in this volume describe bottom-up strategies and chronicle cutting-edge advances from several of the world’s leading laboratories engaged in the development of molecular machines. The Nobel Prize in Chemistry 2016 was awarded jointly to Jean-Pierre Sauvage, Sir J. Fraser Stoddart and Bernard L. Feringa"for the design and synthesis of molecular machines". Both Jean-Pierre Sauvage and Sir J. Fraser Stoddart have also contributed to this book. XII, 236 p. Printed book Hardcover 179,95 € | £142.50 | $269.00 [1]192,55 € (D) | 197,95 € (A) | CHF 299,29 eBook 149,99 € | £114.00 | $209.00 [2]149,99 € (D) | 149,99 € (A) | CHF 239,00 Available from your library or springer.com/shop MyCopy [3] Printed eBook for just € | $ 24.99 springer.com/mycopy Order online at springer.com / or for the Americas call (toll free) 1-800-SPRINGER / or email us at: [email protected]. / For outside the Americas call +49 (0) 6221-345-4301 / or email us at: [email protected]. The first € price and the £ and $ price are net prices, subject to local VAT. Prices indicated with [1] include VAT for books; the €(D) includes 7% for Germany, the €(A) includes 10% for Austria. -
Annual Report 2013.Pdf
ATOMIC HERITAGE FOUNDATION Preserving & Interpreting Manhattan Project History & Legacy preserving history ANNUAL REPORT 2013 WHY WE SHOULD PRESERVE THE MANHATTAN PROJECT “The factories and bombs that Manhattan Project scientists, engineers, and workers built were physical objects that depended for their operation on physics, chemistry, metallurgy, and other nat- ural sciences, but their social reality - their meaning, if you will - was human, social, political....We preserve what we value of the physical past because it specifically embodies our social past....When we lose parts of our physical past, we lose parts of our common social past as well.” “The new knowledge of nuclear energy has undoubtedly limited national sovereignty and scaled down the destructiveness of war. If that’s not a good enough reason to work for and contribute to the Manhattan Project’s historic preservation, what would be? It’s certainly good enough for me.” ~Richard Rhodes, “Why We Should Preserve the Manhattan Project,” Bulletin of the Atomic Scientists, May/June 2006 Photographs clockwise from top: J. Robert Oppenheimer, General Leslie R. Groves pinning an award on Enrico Fermi, Leona Woods Marshall, the Alpha Racetrack at the Y-12 Plant, and the Bethe House on Bathtub Row. Front cover: A Bruggeman Ranch property. Back cover: Bronze statues by Susanne Vertel of J. Robert Oppenheimer and General Leslie Groves at Los Alamos. Table of Contents BOARD MEMBERS & ADVISORY COMMITTEE........3 Cindy Kelly, Dorothy and Clay Per- Letter from the President..........................................4 -
October 2017 Current Affairs
Unique IAS Academy – October 2017 Current Affairs 1. Which state to host the 36th edition of National Games of India in 2018? [A] Goa [B] Assam [C] Kerala [D] Jharkhand Correct 2. Which Indian entrepreneur has won the prestigious International Business Person of the Year award in London for innovative IT solutions? [A] Birendra Sasmal [B] Uday Lanje [C] Madhira Srinivasu [D] Ranjan Kumar 3. The United Nations‟ (UN) International Day of Non-Violence is observed on which date? [A] October 4 [B] October 1 [C] October 2 [D] October 3 4. Which country to host the 6th edition of World Government Summit (WGS)? 0422 4204182, 9884267599 1st Street, Gandhipuram Coimbatore Page 1 Unique IAS Academy – October 2017 Current Affairs [A] Israel [B] United States [C] India [D] UAE 5. Who of the following has/have won the Nobel Prize in Physiology or Medicine 2017? [A] Jeffrey C. Hall [B] Michael Rosbash [C] Michael W. Young [D] All of the above 6. Which state government has launched a state-wide campaign against child marriage and dowry on the occasion of Mahatma Gandhi‟s birth anniversary? [A] Odisha [B] Bihar [C] Uttar Pradesh [D] Rajasthan 7. The 8th Conference of Association of SAARC Speakers and Parliamentarians to be held in which country? [A] China [B] India [C] Sri Lanka [D] Nepal Correct 8. Which committee has drafted the 3rd National Wildlife Action Plan (NWAP) for 2017- 2031? [A] Krishna Murthy committee [B] JC Kala committee 0422 4204182, 9884267599 1st Street, Gandhipuram Coimbatore Page 2 Unique IAS Academy – October 2017 Current Affairs [C] Prabhakar Reddy committee [D] K C Patan committee 9. -
2006Spring.Pdf
− X8 PROTEUM THE ULTIMATE STRUCTURAL BIOLOGY SYSTEM When you need the best system for Structural Biology, the Bruker X8 PROTEUM offers high-throughput screening AND superb high resolution data in one uncompromising package. With our MICROSTAR family of generators, you can rely on the extremely intense micro-focus X-ray beam coupled with the ultra-bright HELIOS optics to handle everything from small crystals to large unit cells With over 700135 detector CCD detectors for speed, installed, sensitivity, we know size and how dynamic to optimize range the to give PLATINUM you the best data possible in the home lab Our KAPPA goniometer’s high precision mechanics allow you to orient the sample along any axis in reciprocal space, while having easy access to mount, cool or anneal your crystals Get the best data, get the fastest system, get the power to solve your structures – X8 PROTEUM. BRUKER ADVANCED X-RAY SOLUTIONS North America: BRUKER AXS INC Tel. (+1) (608) 276-3000 Fax (+1) (608) 276-3006 www.bruker-axs.com [email protected] Germany: BRUKER AXS GMBH Tel. (+49) (721) 595- 2888 Fax (+49) (721) 595-4587 www.bruker-axs.de [email protected] Netherlands: BRUKER AXS BV Tel. (+31) (15) 215-2400 Fax (+31) (15) 215-2500 www.bruker-axs.nl [email protected] American Crystallographic Association * REFLECTIONS *see page 9 for notes on our new name and for new logo possibilities Cover: Images from Warren Award Recipient Charles Majkrazk and his colleagues; see page 25. ACA HOME PAGE: hwi.buffalo.edu/ACA/ Table of Contents 3 President’s -
The Grand Challenges in the Chemical Sciences
The Israel Academy of Sciences and Humanities Celebrating the 70 th birthday of the State of Israel conference on THE GRAND CHALLENGES IN THE CHEMICAL SCIENCES Jerusalem, June 3-7 2018 Biographies and Abstracts The Israel Academy of Sciences and Humanities Celebrating the 70 th birthday of the State of Israel conference on THE GRAND CHALLENGES IN THE CHEMICAL SCIENCES Participants: Jacob Klein Dan Shechtman Dorit Aharonov Roger Kornberg Yaron Silberberg Takuzo Aida Ferenc Krausz Gabor A. Somorjai Yitzhak Apeloig Leeor Kronik Amiel Sternberg Frances Arnold Richard A. Lerner Sir Fraser Stoddart Ruth Arnon Raphael D. Levine Albert Stolow Avinoam Ben-Shaul Rudolph A. Marcus Zehev Tadmor Paul Brumer Todd Martínez Reshef Tenne Wah Chiu Raphael Mechoulam Mark H. Thiemens Nili Cohen David Milstein Naftali Tishby Nir Davidson Shaul Mukamel Knut Wolf Urban Ronnie Ellenblum Edvardas Narevicius Arieh Warshel Greg Engel Nathan Nelson Ira A. Weinstock Makoto Fujita Hagai Netzer Paul Weiss Oleg Gang Abraham Nitzan Shimon Weiss Leticia González Geraldine L. Richmond George M. Whitesides Hardy Gross William Schopf Itamar Willner David Harel Helmut Schwarz Xiaoliang Sunney Xie Jim Heath Mordechai (Moti) Segev Omar M. Yaghi Joshua Jortner Michael Sela Ada Yonath Biographies and Abstracts (Arranged in alphabetic order) The Grand Challenges in the Chemical Sciences Dorit Aharonov The Hebrew University of Jerusalem Quantum Physics through the Computational Lens While the jury is still out as to when and where the impressive experimental progress on quantum gates and qubits will indeed lead one day to a full scale quantum computing machine, a new and not-less exciting development had been taking place over the past decade.