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Chemistry N E W S L E T T E R University of Michigan Chemistry N E W S L E T T E R Letter from the Chair The last year has brought a number of 30, 2016. I encourage you all to join Contents exciting developments in the Chemistry de- these donors in supporting undergraduate partment. In this newsletter we are pleased research opportunities by designating a gift Letter from the Chair ........................ 1 to introduce our newest departmental hire, to support “Undergraduate Research” on Brent R. Martin, whose work at the inter- the enclosed reply envelope. New Faculty ..................................... 2 face of chemical biology and analytical Faculty News.................................... 2 The summer research fellowship pro- chemistry sheds light on the identification gram matches undergraduate chemistry Faculty Profiles.................................. 4 of novel disease targets. Additionally we and biochemistry majors with Michigan are proud to profile the research of Prof. Graduate Program News faculty on campus every summer, provid- Melanie S. Sanford for which she was ing what is often the formative experience Degrees......................................... 5 awarded a 2011 MacArthur Foundation in a research lab. Stipends of approxi- Vaughan/Fajans ............................. 6 Fellowship, the “genius” award, among mately $3,500 are awarded to talented numerous other recent honors. Awards ........................................... 7 students for 10 weeks of research, and The positive trajectory of the depart- demand for fellowships far exceeds our Undergraduate Program News ment has been recognized in our continu- ability to fund them. Currently, we identify Degrees.......................................... 8 ally improving rank in the US News and more than 30 outstanding students from Awards ........................................... 8 World Report rankings (currently at 16) a large applicant pool who would benefit and our QS World University Ranking from this program. To date we have been Summer Programs ........................ 9 in Chemistry of 25 (16 in the US only). able to identify summer support for ap- Gifts ................................................. 10 Our level of research funding has also proximately 15 students using a mix of Alumni News ............................. 11-12 been rapidly rising and we rank in the discretionary funds and research grants. As top 20 in terms of schools with the most federal agency support for this important In Memoriam .................................. 13 federal support for chemical research and educational mission wanes, it is especially Faculty Listing ................................. 14 development. important to generate additional resources Alumni Reply for this critical program and I hope you The Chemistry Department is com- Form ................. inside back cover will consider making a contribution to this mitted to providing the best educational or one of our other areas of need. Donations ..............reply envelope flap experience for the University of Michigan undergraduate and graduate students, in- Both educational and research missions cluding the opportunity for undergraduate of the Chemistry Department are growing students to experience the thrill of scientific and thriving, despite budget challenges. research. To further this aim, two longtime, The Chemistry Department and I are generous donors to the department have grateful for your contributions and sup- pledged $200,000 in financial support for port of our endeavors to teach the future summer research funding for undergradu- generation of scientists and leaders. The 2011 ate students in the Department of Chemis- loyal donors to the Department’s various try. To help demonstrate their tremendous gift funds, scholarships and endowments The Regents of the University of Michigan: commitment to Michigan Chemistry, they are enumerated elsewhere in this newslet- Julia Donovan Darlow, Laurence B. Deitch, Denise Ilitch, Olivia P. Maynard, Andrea Fischer Newman, Andrew C. Richner, S. are challenging fellow alumni, donors, and ter. On behalf of the students and faculty Martin Taylor, Katherine E. White, Mary Sue Coleman, ex officio. former faculty to contribute an additional who benefit from this support, I thank you Mary Sue Coleman, president. The University of Michigan is an equal opportunity/affirmative $200,000 to the same program by June sincerely. I hope that you will come and action employer. 2011 U-M DEPARTMENT OF CHEMISTRY visit the Department anytime that you are in town. I look forward to meeting alumni/ anisms that control this lipid modification alumnae visitors. remain poorly characterized. In order to Best wishes, understand the processes regulating dy- Carol Ann Fierke, Chair namic palmitoylation, we have developed Jerome and Isabella Karle Professor of Chemistry and Professor of Biological a quantitative chemo-proteomic platform Chemistry using cutting edge mass spectrometry applied to global comparative analysis of palmitoylated proteins, and used this platform to interrogate the population of palmitoylated proteins regulated by both Spotlight: Profiles of New Faculty palmitoyl transferases and thioesterases implicated in cancer and neurological We highlight faculty members who have joined the Department since the last newsletter. diseases. Additionally, using competitive Their appointment speaks well for our future. activity-based high throughput screening, we identified a new class of mechanism- Brent R. Martin chemical probes, mass spectrometry, and based in vivo-active, potent, and highly Assistant Professor imaging technologies presents a unique selective inhibitors to enzymes proposed PhD: UC San Diego opportunity for broad training in chemical to regulate protein palmitoylation. In PostDoc: Scripps Research Institute biology. This multidisciplinary approach combination with novel activity-based Bioanalytical Chemistry will rely on technological probes, we identified a unique subset of innovation focused on enzymatically regulated, dynamically Our group aims to explore the unexplored biochemical palmitoylated proteins in cells. function and physiological role pathways and their links of novel enzymes and lipids Understanding the functional role of to human disease. involved in the development dynamic post-translational modifications of neurological diseases and Cysteine residues in in disease will be explored through the cancer. To achieve these goals, proteins have pKa values application of new inhibitors and genetic we propose to bridge chemi- close to neutral and are models to test the importance of potential cal, analytical, and biological often in their reactive therapeutic targets in vitro and in vivo. approaches to identify novel thiolate form in cells, Additionally, these methodologies will disease targets and develop making them nucleophilic be used to globally assign substrates to new approaches for therapeutic and targets of distinct unannotated enzymes, as well as the intro- intervention. Our expertise in post-translational modi- duction of new fluorescence microscopy cell and molecular biology, fications. One such modi- approaches for visualizing the spatial fication, termed protein S-palmitoylation, and temporal control of membrane com- describes the thioester linkage of palmitic partmentalization. Furthermore, through the development of an expanded suite acid and cysteine in proteins, and is re- Department of Chemistry quired for membrane association and spa- of chemical probes, we will explore the tial regulation of diverse cellular pathways enzymology, regulation, interactions, and Newsletter involved in cell growth and signaling. In function of novel enzymes involved in the is published once a year by the Department many cases, palmitoylation is thought to be biosynthesis and degradation of unique of Chemistry at the University of Michigan, lipids altered in specific disease states. Ann Arbor, MI 48109-1055 dynamically regulated, although the mech- Faculty News as 50-year members of the American Chemical Society. Printed on Recycled Paper Hashim Al-Hashimi was featured in Julie Biteen received the PicoQuant the October 2010 issue of Popular Science Young Investigator Award. She was Chair: Carol Fierke magazine as one of the “Brilliant Ten.” recognized at the 2011 SPIE Photonics Editor: Arthur J. Ashe, III Each year the magazine picks the ten most Publication: Agnes Soderbeck West Conference for applying single Alumni News: Arthur J. Ashe, III, innovative young US-based scientists and molecule and super-resolution imaging Robert Kuczkowski features them in a special issue. Hashim to live bacterial cells. Julie is part of a was cited for his pioneering work record- UM team of researchers who have been ing “nano-movies” of RNA and DNA granted an NSF Materials Research Sci- Web Address: showing how these vital biomolecules ence and Engineering Center for Photonic wiggle and move. http://www.umich.edu/~michchem and Multiscale Nanomaterials. E-mail: [email protected] Arthur Ashe, Michael Morris and Charles Brooks, the Warner-Lambert/ John Wiseman were honored this year Parke Davis Professor of Chemistry, has 2 2011 been included on the Thomson Reuters organic chemistry. Anna has been elected Brandon Ruotolo won the American Science Watch List, “Top 100 Chemists, a Fellow of the American Association for Society for Mass Spectrometry Research 2000-2010.” Charles’ work focuses on the Advancement of Science (AAAS). Award. The objective of the award is understanding the forces that
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