University of Michigan hemistry C N E W S L E T T E R

Letter from the Chair

I am pleased to send greetings and to To move forward with some of these ideas, Contents highlight the activities of the Chemistry we organized an alumni dinner associated Department this past year – my first full with Professor Morris’ Sokol Award lecture Letter from the Chair...... 1 year as Chair of the Department. Faculty last spring. Furthermore, we are organiz- Advisory Board Meeting...... 3 and graduate student recruiting and depart- ing an alumni event this spring (May 11 New Faculty...... 4 mental development activities continue to & 12; see attached story) to celebrate the be major priorities. I am pleased to report 150th anniversary of the establishment of Faculty News...... 7 that the Department had tremendous success a Chemistry laboratory at the University 150th Birthday...... 8 on these fronts. of Michigan. This weekend will include Graduate Program News The Chemistry Department and I are research seminars, educational seminars very thankful for the receipt of a significant and a poster session to highlight ongoing Graduate Awards...... 8 bequest from the wills of Margaret and efforts in the department. This will be Graduate Degrees...... 11 held in conjunction with the annual Pfizer Herman Sokol. These funds are being used GS Council News...... 13 to establish an endowed Professorship in symposium on May 11. In addition, the Chemistry entitled the Margaret and Herman Department will be awarded a 2006 Cita- Undergraduate Program News Sokol Professorship in Medicinal (or Syn- tion for Chemical Breakthroughs from the REU Program...... 14 Division of the History of Chemistry of the thetic) Chemistry as well as two endowed Undergraduate Awards...... 15 graduate fellowships entitled the Margaret American Chemical Society in recognition and Herman Sokol Fellowship Fund in the of work by Moses Gomberg. Professor Undergraduate Degrees ...... 17 Chemical Sciences. In addition, the Sokols Harold Kroto, awarded the 1996 Nobel Gifts...... 18 Prize in Chemistry for the discovery of provided funds to LSA for a faculty award Alumni News ...... 19 and to Rackham for a Summer Graduate fullerene, will be the keynote speaker for Fellowship. These endowed positions in this event. Please save these dates. De- In Memoriam ...... 20 Chemistry provide a great boost to our tailed information about this event will be Faculty Listing...... 22 recruiting efforts and a lasting memorial provided early next year. Alumni Reply to the Sokol family. My colleagues and I are very proud Form ...... inside back cover The Chemistry Department is interested that we hired three outstanding junior in strengthening contacts with alumni and faculty candidates who started as assistant alumnae. To this end, Bob Kuczkowski professors in Chemistry on August 1. With and I organized a meeting last fall for the these hires, the Department has a cohort of 2005-2006 department’s external advisory board, and 11 assistant professors (1/3 female). Dr. other interested alums where we discussed Nicolai Lehnert received his Ph.D. from ways to enhance our alumni outreach efforts. the Institute of Inorganic and Analytical The Regents of the University of Michigan: David A. Brandon, Laurence B. Deitch, Olivia P. Maynard, Re- Michigan Chemistry Celebrates its 150th becca McGowan, Andrea Fischer Newman, Andrew C. Richner, S. Martin Taylor, Katherine E. White, Mary Sue Coleman, ex Birthday in May, 2007 officio. Mary Sue Coleman, president. The University of Michigan is an equal opportunity/affirmative See page 8 action employer.

2006 U-M DEPARTMENT OF CHEMISTRY Chemistry at Johannes Gutenberg Uni- Karbstein received her Ph.D. degree from been promoted from Assistant Professor versity, Mainz, Germany working with the Biochemistry Department at Stanford to Associate Professor with tenure: Eitan Drs. F. Tuczek and P. Gutlich and was a University where she was awarded a Geva, Anna Mapp and Adam Matzger. postdoctoral fellow in the laboratory of Boehringer Ingelheim Predoctoral Fel- All three have established themselves as Professor Ed Solomon in the Chemistry lowship working with Professor Daniel outstanding teachers and researchers. The Department at Stanford. Following this, Herschlag. She then moved to the labora- faculty, staff and students of the Chemistry he moved to Christian-Albrechts Univer- tory of Professor Jennifer Doudna at the Department applaud the outstanding ef- sity Kiel, Germany where he completed University of California, Berkeley as a forts, summarized below, of these newly his Habilitation with Professor F. Tuczek. Damon-Runyon Postdoctoral fellow. At promoted faculty members. Throughout his career, Dr. Lehnert has the University of Michigan, Dr. Karbstein Professor Geva has garnered praise and focused on synthesizing and character- has been recognized as a Biological Sci- respect as one of the best young theoreti- izing inorganic complexes that model the ences Scholar. Katrin is an expert in the cal chemists in the country. He has been active sites of important metalloenzymes. function of RNA and RNA-protein com- a leader in developing both methods At the University of Michigan he proposes plexes and in her own research program and theory in the simulation of quantum to investigate the synthesis, function and she plans to investigate the assembly of dynamics of molecules in the condensed degradation of nitric oxide in the bio- eukaryotic ribosomes at the molecular phase. Within the Chemistry Department, sphere by synthesizing heme-nitrosyl level combining enzymology techniques, Eitan is playing a key leadership role model complexes and investigating their chemical biology tools and yeast genetics in the creation of a first-rate theoretical electronic structures and reactivities using to dissect the roles of proteins required for chemistry group. He has been active in spectroscopic methods and density func- correct assembly of the small ribosomal recruiting both graduate students and tion calculations. As part of his start-up subunit. Katrin is an outstanding addi- faculty in the area of Physical Chemistry. package, the Chemistry Department and tion to the Chemical Biology faculty and Professor Geva is an enthusiastic teacher the College of Literature, Science and Arts significantly strengthens the subgroup of who brings humor to his physical chem- have provided funds to purchase magnetic Chemistry faculty whose research focuses istry lectures. circular dichroism and resonance raman on the structure and function of RNA. spectrometers which will significantly Professor Mapp has been praised as a Our third recruit, Dr. Kate Carroll, creative researcher and leader in the area enhance the spectroscopic facilities in the was hired jointly with the Life Sciences department. Dr. Lehnert is an important of Chemical Biology, ranking among the Institute at the University of Michigan. best academicians in her peer group. She addition to the Department’s research effort Dr. Carroll received her Ph.D. degree in inorganic and bioinorganic chemistry. has received numerous awards, notably from the Stanford University Biochemis- the 2007 Eli Lilly Award (ACS), the As part of our ongoing effort to further try Department where she worked in the 2005 Presidential Early Career Award for strengthen the Chemical Biology research laboratories of both Professor Dan Her- Scientists & Engineers (along with UM group in Chemistry, we hired two new schlag and Professor Susan Pfeffer as an chemistry professor Melanie Sanford) faculty members in this area. Dr. Katrin American Heart Association fellow. As a and the 2006 Class of 1923 Memorial Damon-Runyon postdoctoral fellow in the Teaching Award (LSA). Anna’s research laboratory of Professor Carolyn Bertozzi is at the interface of organic chemistry, Department of Chemistry at the University of California, Berkeley biochemistry and medicinal chemistry she focused on identifying pathogenic Newsletter where she has focused on the synthe- pathways in Mycobacterium tuberculosis. sis, discovery and mechanism of small is published once a year by the Department Dr. Carroll has also been designated a molecules that can mimic the function of Chemistry at the University of Michigan, University of Michigan Biological Sci- Ann Arbor, MI 48109-1055 of biological macromolecules to activate ences Scholar. Kate’s research focuses on gene transcription. Professor Mapp has problems at the intersection of chemical been active in graduate education where biology, organic chemistry and medicinal she has contributed to the development chemistry. She is particularly interested of the new Interdepartmental Graduate in investigating novel metabolic pathways Program in Chemical Biology, worked to Printed on Recycled Paper that can be targeted for anti-tuberculosis bring a more diverse student population therapy and in developing new chemical into our graduate program and now serves tools to identify and study oxidative post- as Chair of the Graduate Committee. Chair: Carol A. Fierke translational modifications associated with Editor: Robert Kuczkowski, Tim Wade age and neurodegenerative diseases. Kate Professor Matzger has earned national Publication: Agnes Soderbeck was recently honored with a Special Fellow and international recognition as a leading Alumni News: Robert Kuczkowski Award from the Leukemia and Lymphoma researcher in the field of organic materials Association to help support this project. Dr. chemistry, especially solid-state materials, Carroll’s research space will be located in as indicated by receipt of awards from World Wide Web Address: the Life Sciences Institute building. the Alfred P. Sloan Foundation and the http://www.umich.edu/~michchem Beckman Foundation. Adam’s lab both In the past year three faculty members synthesizes new materials and analyzes E-mail: [email protected] from the Chemistry Department have the molecular structure and properties of

 2006 these materials. His research program is the University of Michigan to accept an and related interdepartmental graduate highly interdisciplinary and collaborative, appointment in the Department of Chem- programs continues to increase. You will bridging organic chemistry, materials istry and Biochemistry at the University of see accolades to the students elsewhere in chemistry and materials research in the California - Los Angeles. We wish these the newsletter. Macromolecular Science and Engineer- faculty members all the best in their new Both the educational and research mis- ing program. Professor Matzger is an endeavors. sions of the Chemistry Department are inspiring teacher and outstanding mentor The educational mission of the depart- growing and thriving and the future looks to many undergraduate and graduate stu- ment continues to thrive, increasing in very bright, despite budget difficulties at dents. Adam has been active in recruiting both quantity and quality. The number of the state level and decreased funding at graduate students, especially underrepre- students in our gateway Chemistry courses the federal level. We are most grateful sented minority students, identifying and has increased by 50% over the last three for your contributions and support of recruiting new faculty, and in building the years demonstrating the importance of our endeavors to teach the future genera- material sciences cluster in the Chemistry Chemistry for a wide range of majors! Ad- tion of scientists and leaders. The loyal Department and nanomaterials campus- ditionally, the Chemistry faculty continue donors to the Department’s various gift wide. to incorporate innovative teaching meth- funds, scholarships and endowments are Over the past year the senior faculty ods into our courses, including the use of enumerated elsewhere in this newsletter. ranks have decreased. We were saddened electronic personal response systems and Please continue your support as this is by the death of Professor Richard D. Sacks podcasts of lectures. In the fall semester, essential to maintain the Department’s on February 11 after a courageous battle Professor Banaszak Holl has begun using activities. On behalf of the students and with cancer. Sacks was a truly outstanding the studio labs in the new Undergraduate faculty who benefit from this support, I educator and an internationally recognized Science Building to teach a combined thank you sincerely. I hope that you will expert on analytical instrumentation (see lecture/lab for introductory Chemistry. come and visit the Department either at the article). Professor Paul Rasmussen retired Professors Penner-Hahn and Sension have Alumni weekend in the spring or anytime after 42 years as a faculty member devel- used the dinner theater room equipped that you are in town. I look forward to oping novel materials, educating students with tablet PCs to teach an introductory meeting alumni/alumnae visitors. and serving as associate dean. Professor physical chemistry course. Brian Coppola David Lubman moved his primary appoint- is leading a Future Faculty Development ment from the Chemistry Department to effort for graduate and postdoctoral stu- Best wishes, the Surgery Department in the University dents including both lectures and discus- Carol Ann Fierke, Chair of Michigan Medical School. David still sions about pedagogy as well as hands-on Jerome and Isabella Karle Professor of has an active presence in the Department practice in the classroom. The number Chemistry and Professor of Biological as he retains a complementary appoint- and quality of graduate students in the Chemistry ment. Finally, Professor Omar Yaghi left Department from the Chemistry Program

Alumni-Alumnae Advisory Board Meeting, for gifts, and celebrations of faculty milestones. In attendance November 11, 2005 were Terry Hilty, Joe and Karen Morris, Tom Smith, Kathy Hillig, Gary McGraw, Les Browne, Dave Scott, Helen Schaefer (by phone) and Bob Damrauer (by phone). Catherine Musselman First created in 1992, Chair Carol Fierke called a reunion and Jeniffer Cunliffe represented the Graduate Student Council. meeting last fall to update former and current members, and The dialogue was spirited and constructive. The day concluded several potential new participants of changes in the department. with dinner at a new Ann Arbor restaurant and football game The half day meeting commenced with a luncheon attended attendance the next day by several of the visitors. by students, postdocs and faculty. Informational reports fol- Alumni and alumnae are invited to write or email Bob Kuc- lowed lunch, presented by Fierke and associate chairs Brian zkowski ([email protected]) with comments on the topics Coppola and Masato Koreeda. The meeting then segued into discussed, interest in the Alumni-Alumnae advisory board and a brainstorming session led by Bob Kuczkowski on improving activities that would be of interest to our alums. Attention is alumni outreach efforts. This far reaching discussion explored directed at the 150th birthday celebration in May 2007, mentioned ideas ranging from newsletter design and web interface, reunion elsewhere in this newsletter, as an opportunity for alumni and events, mentoring graduate students by alumni and alumnae, the alumnae to visit the department. future job market for chemists, how industry seeks applicants and applications for employment, mail and phone solicitations

U-M DEPARTMENT OF CHEMISTRY  Spotlight Profiles on New Faculty We highlight faculty members who have joined the department since the last newsletter. Their appointment speaks well for our future.

Kevin J. Kubarych Assistant Professor of Chemistry Ph.D., University of Toronto Physical and Biophysical Chemistry

The boundaries between traditional disciplines are eroding, and some of the most exciting and important discoveries are taking place at the intersections of historically distinct fields. Our group embraces this shift by investigating fundamental questions of chemical and biological structure and dynamics from an essentially physical perspective. Biological systems such as proteins, nucleic acids, membranes, cells, and organelles present spectacular challenges to our understand- ing of chemical dynamics and structure in complicated heterogeneous environments. Most protein molecules have reasonably well-defined structures to the extent that they can be characterized by X-ray diffraction and NMR spectroscopy. These structures, though, must necessarily respond to their environments, which can range from surfaces to solids to water to oily membranes. Globular proteins, for example, are nearly solid density, and yet to function they must often be flexible. One of the distinguishing features of many biological molecules is that they are not neatly categorized as solids or liquids, but rather something in between.

Kevin J. Kubarych In order to push towards a detailed microscopic description of these hard-to-classify biological systems, we are developing an array of optical spectroscopy tools that will complement the already commonly used X-ray and NMR techniques. We rely heavily on state-of-the-art femtosecond (1 fs = 10-15 sec) laser pulses. Through various nonlinear optical processes we are able to generate significantly intense pulses at any wavelength from the ultraviolet to the infrared. Our main approach is to take advantage of the rich chemical specificity and well-developed intuition of vibrational transitions in order to track the course of chemical events. Vibrational transitions can be excited through infrared absorption, and the information content relates directly to the displacement of atoms, thus limiting our reliance on the complicated dynamics of electronic transitions. Our experimental approach is based on the workhorse of multidimensional IR spectroscopy. This new technique allows us to find out how different motions are coupled together. In particular we are using these powerful new spectroscopic probes to address nonequilibrium dynamical questions. Phototriggered chemical reactions often take place on the femtosecond to picosecond time scale, and by using multidimensional IR as a probe we can directly map the reactant vibrations to those of the product, giving a bond-by-bond view of the reaction’s progress with femtosecond resolution.

John Montgomery Professor of Chemistry Ph.D., Colorado State University Organic, Organometallic Chemistry, Complex Molecule Synthesis

Our research program focuses on the discovery of new transition metal-catalyzed reactions, the development of useful synthetic methods, the application of these new reactions in complex molecule synthesis, and mechanistic studies designed to understand the new processes developed in our laboratories. A major focus of our research program in recent years has been the develop- ment of new reactions involving nickel catalysis. In particular, our lab has discovered a series of new reactions that involve the reductive coupling of two different unsaturated moieties in a Ni(0)- catalyzed process. A broad range of pi-systems, including aldehydes, enones, alkynes, allenes, and dienes, are effective participants in this group of reactions. The challenges addressed by the John Montgomery new reactions being developed in our group include the stereoselective introduction of exocyclic double bonds and the stereoselective preparation of polycyclic ring systems that possess multiple contiguous stereocenters. Precise control of catalyst structure and reaction conditions allows a

 2006 wide array of reaction pathways to be accessed from simple, readily available starting materials. A variety of natural products have been synthesized in our laboratories using these methods, including isodomoic acids G and H, allopumiliotoxins 339A and 339B, and testudinariol A. We have recently discovered a new three-component cycloaddition reaction for the synthesis of complex seven-membered rings by a [4+2+1] cycloaddition pathway involving diazoalkanes, alkynes, and dienes. We are actively pursuing the development of new cycloaddition processes based on the novel reactivities uncovered, and we plan to develop applications of these new reactions in complex molecule total synthesis. A third area of interest is the discovery of new three-component coupling processes involving conjugate addition strategies that avoid the use of metallated nucleophiles. The sensitive nature of organocuprates often limits their utility in synthesis, and we have initiated a program to allow stable and commercially available aryl iodides to be directly utilized in conjugate additions.

Kate S. Carroll Assistant Professor of Chemistry Research Assistant Professor, LSI Ph.D., Stanford University Biochemistry, Bioinorganic Chemistry, and Chemical Biology

We are a young research group in the Department of Chemistry and the Life Sciences Institute at the University of Michigan that uses biochemistry, organic chemistry, and chemical biology ap- proaches to address problems relevant to human health and disease. Our program has two major focuses: microbial metabolism and oxidation biology. In the host-pathogen arena, we are investi- gating metabolic pathways that allow Mycobacteria to replicate and persist. Our efforts in oxida- tion biology are directed at developing new chemical tools to identify and study post-translational modifications associated with aging and neurodegenerative diseases. A hallmark of our program is Kate S. Carroll the ability to make new molecules and use them for a targeted function. This make-and-measure philosophy allows students and postdocs in the group to take their own projects from start to finish. We synthesize a variety of molecules ranging from small-molecule inhibitors, non-natural peptides, probes for post-translational modifications in living cells and also use directed evolution to gener- ate novel catalysts. In turn, we apply a host of spectroscopic, structural, and biological techniques to evaluate the properties and capabilities of newly synthesized molecules and catalysts, including FT-ICR mass spectroscopy, X-ray crystallography, quantitative kinetic analysis and cell biology techniques including tissue culture and subcellular organelle fractionation.

Katrin Karbstein Assistant Professor of Chemistry Ph.D., Stanford University Biochemistry

We use a combination of approaches – including biochemistry, mechanistic enzymology, chemi- cal biology, protein engineering and yeast genetics - to study eukaryotic ribosome assembly at the molecular level. Our ultimate goal is to understand the function of assembly factors, the order of events as well as the rationale for this order, aiming to delineate principles important for the as- sembly of other large RNA-protein complexes, such as the spliceosome or the signal recognition particle. Ribosomes are large macromolecular machines that catalyze protein synthesis in all cells. Groundbreaking work in bacteria has provided insight into the order of binding of ribosomal Katrin Karbstein proteins to ribosomal RNA (rRNA) and has given a structural and thermodynamic rationale for this order. However, in eukaryotic cells the assembly process is much more complex, requiring a macromolecular machinery of > 170 proteins and > 70 RNAs. While we know that this machinery is absolutely essential, we have little understanding of the function of the individual players. By

U-M DEPARTMENT OF CHEMISTRY  taking a biochemical approach to study these proteins, which is complemented by in vivo work in the yeast S. cerevisiae, we are pioneering the study of the molecular function of these proteins. To tackle this fascinating problem we have focused on subcomplexes and their functions. Specific projects include: Chemical Biology Tools for Dissecting Ribosome Assembly • To rapidly isolate unstable intermediates in ribosome assembly we will establish small- molecule control over ribosome biogenesis. Intermediates will then be purified and analyzed by mass spectrometry and RNA structure mapping. By analyzing distinct assembly intermediates we will establish a ribosome assembly map. The Role of an Essential GTPase in Ribosome Assembly • GTPases act as molecular switches triggered by hydrolysis of GTP to GDP. Using muta- genesis and kinetic analysis we are dissecting in molecular detail how the switch operates in the essential ribosome assembly factor Bms1. In addition we are characterizing structurally and functionally a novel RNA binding site within Bms1. RNA Conformational Changes in Ribosome Assembly • DEAD box proteins are ATP-dependent enzymes that catalyze unwinding of RNA struc- tures and dissociation of RNA-binding proteins. They are ubiquitously involved in ribosome assembly, yet their function in this process remains unknown. We want to identify and char- acterize DEAD box proteins involved in a conformational switch that controls folding of the small ribosomal subunit.

Nicolai Lehnert Assistant Professor of Chemistry Ph.D., University of Mainz, Germany Bioinorganic Chemistry, Physical Inorganic Chemistry, Bioorganometallic Chemistry

Research that is currently pursued in my group is focused on the biological nitric oxide (NO) metabolism; i.e. the synthesis, function and degradation of nitric oxide in the biosphere. Nitric oxide is a poisonous gas, which, however, has proven to be of great biological significance. It plays a key role in nerve signal transduction, vasodilation, blood clotting and immune response by white blood cells. Many of the biologically important reactions of NO are mediated by heme proteins. Nitric oxide also occurs as intermediate in denitrification. Here, NO is produced by nitrite reductase (NIR) and further reduced to nitrous oxide by the nitric oxide reductases (NOR). Current research goals are the elucidation of the reaction mechanisms of the corresponding bacterial (NorBC) and fungal (P450nor) NORs, which catalyze the same reaction but utilize very different active sites and hence, Nicolai Lehnert reaction mechanisms. To this end, a dual strategy is applied. Firstly, “simple” model complexes of type [Fe(TPP*)(L)(NO)]n+ (TPP* = tetraphenylporphyrin type ligand; L = N-donor, thiolate, etc.) are synthesized, which allow for the routine investigation of the porphyrin substituent and trans-ligand effect on the coordinated NO. Complementarily, we are working on the synthesis of sophisticated model complexes for both NorBC and P450nor. These compounds are then investigated using a variety of spectroscopic techniques including vibrational (FT-IR and resonance Raman), magnetic circular dichroism (MCD), electron paramagnetic resonance (EPR), nuclear magnetic resonance (NMR), and Mössbauer spectroscopy in correlation with density functional theory (DFT) calcula- tions. The results obtained are not only important for the understanding of the mechanisms of these enzymes, but are also relevant for the various biological functions of NO. Besides the research on the biological role of nitric oxide, we are also very interested in the fields of (a) Bioorganometallic Chemistry; i.e. the conduction of organometallic chemistry in aqueous solution using proteins with modified active sites. In this respect, I am especially interested in the usage of small heme proteins for organometallic reactions. (b) Anti-Cancer Drugs based on Ru- NO compounds, especially their interaction with DNA, their photophysical properties, and their mechanisms of activation. These research areas are currently being developed in my group.

 2006 Faculty News for his accomplishments as a researcher Carol also received the 2005 Power Award and educator. for her leadership, scholarship and sus- tained service on behalf of women. Anna Mapp (NSF) and Melanie Kristina Hakansson has been awarded Sanford (NIH) have been awarded 2005 the American Society for Mass Spectrom- The 2006 James Flack Norris Award for Presidential Early Career Awards for etry Research Award for 2005. She is also Outstanding Achievement in the Teaching Scientists and Engineers. They were two the recipient of an Eli Lilly Analytical of Chemistry has been awarded to Brian of fifty-six researchers honored on July Chemistry Award made to untenured Coppola. The award is given annually by 26, 2006 in a ceremony presided over by faculty in recognition of their developing the ACS Northeastern Section. It recog- John H. Marburger III, science advisor to research program. nizes an individual whose dedication and the President and Director of the White excellence in the teaching of chemistry Ioan Andricioaei, Heather Carlson, House Office of Science and Technology have had wide-ranging effects on the Kristina Hakansson and Melanie San- Policy. Each presidential award winner profession. receives a citation, a plaque, and a com- ford received a 2005 National Science mitment for continued funding of their Foundation Career Award. Dimitri Coucouvanis was elected a fellow of the American Association for the work for five years from the agency that Heather Carlson received the Wiley Advancement of Science, one of five Uni- nominated them. International Journal of Quantum Chem- versity of Michigan faculty so recognized istry Young Investigator Award (2006), Anna Mapp received one of the three in 2006, for distinguished contributions and the College of Pharmacy’s Student GlaxoSmithKline Chemistry Scholars to their field. Awards in 2005, an award recognizing Appreciation Award for Excellence in excellence in synthetic chemistry and Teaching (2005). Roseanne Sension has been selected as a recipient of an LSA Excellence in Educa- chemical biology. Anna also was named Mark Meyerhoff has been selected tion Award for her special contributions to recipient of the 2006 Amgen Young In- to receive the inaugural University of the College’s educational mission. vestigator Award to recognize scientific Michigan Rackham Distinguished Gradu- contributions and academic excellence. ate Mentor Award for 2006. Mark was Neil Marsh was admitted as a Fellow She received the 2006 Class of 1923 Me- awarded the Charles N. Reilly Award in of the Royal Society of Chemistry. This morial Teaching Award from the College Electroanalytical Chemistry from the honor is bestowed on individuals who of Literature Science and the Arts for the Society for Electroanalytical Chemistry at have demonstrated “substantial career teaching of undergraduates. The 2007 the March 2006 PittCon conference. progression and who can offer evidence of seniority and maturity of experience Eli Lilly Award in Biological Chemistry, The 2005 ACS Division of Analytical in any field which involves or promotes from the Division of Biological Chemistry Chemistry Award in Spectrochemical the advancement or wider application of of the American Chemistry Society will Analysis was awarded to Raoul Kopel- chemical science.” be awarded to Anna at the ACS national man at a symposium in his honor at the meeting in Boston in August, 2007. Spring 2005 ACS meeting. Raoul has Jim Penner-Hahn will serve as LSA Melanie Sanford has been awarded the been appointed as the Richard Smalley Associate Dean for the Natural Sciences for Boehringer Ingelheim New Investigator Distinguished University Professorship a three year term beginning September 1, Award in Organic Chemistry for 2004. of Chemistry, Physics, and Applied Phys- 2006. He joins Anthony “Rick” Francis, She was recipient of the Bristol-Myers- ics. He was previously the Kasmir Fajans Associate Dean for Budget, as a member Squibb Unrestricted Grant in Synthetic Collegiate Professor in the College of of the College’s senior staff. Organic Chemistry in 2005, and one of two Literature, Science and Arts. recipients of an AstraZeneca Excellence in Michael Morris has been awarded the Chemistry Award for 2006. Melanie has Mann Award given by the Federation of been awarded a Research Corporation Cot- Analytical Chemistry and Spectroscopy trell Scholar Award (2006) for her ability Societies for achievements in applied Ra- to mount a strong research program and man spectroscopy. He is also the recipient her contributions to teaching, particularly of the Meggers Award given by the Society undergraduates. of Applied Spectroscopy for the best paper Alfred P. Sloan Research fellowships in Applied Spectroscopy in 2005. have been awarded to Melanie Sanford The Margaret and Herman Sokol Fac- (2006) and Adam Matzger (2005). These ulty Award in the Sciences were awarded awards are intended to enhance the careers in 2005 to Vincent Pecoraro and in 2006 of the best young faculty members in vari- to Michael Morris. This annual award ous fields of science. recognizes distinguished contributions John Wolfe and Melanie Sanford to graduate education, scholarship and were recipients of the 2005 Lilly Grantee research. Award in Organic Chemistry, (out of three Carol Fierke was selected for the Dis- grantees). John is also one of the 2006 Ca- tinguished Faculty Achievement Award mille Dreyfus Teacher-Scholar awardees for 2005 by the University of Michigan. Melanie Sanford, Anna Mapp and George W. Bush

U-M DEPARTMENT OF CHEMISTRY  Michigan Chemistry 150th Birthday

In the fall of 1856, the Regents of the University of Michigan authorized the construction of the first chemistry building at a U.S. public institution with an allocation of $2,500. Construction began in 1857. To celebrate this anniversary, the Chemistry Department is planning two days of activities in the spring, 2007. The celebration will begin with the annual Pfizer-Chemistry Depart- ment symposium on Friday, May 11, 2007. The four speakers, yet to be announced, will focus on recent research at the interface of chemistry, chemical biology and medicinal 1857 Chemistry Building chemistry. After these presentations, remarks to commemorate the history of the depart- ment will be made, and Harold Kroto (Nobel Laureate, 1966) will present an exciting chemistry talk of general interest, followed by a reception in the atrium. A banquet to which the department faculty and students invites its alumni and alumnae will conclude the day’s activities. On Saturday, May 12, the department will have an open house with several workshops/presentations that highlight recent educational and research initiatives in the department. Educators and students from across Michigan and neighboring states will attend. For further information contact Nils Walter, Neil Marsh, Bob Kuczkowski or Brian Coppola, co-chairs of the events. Celebration Dates Annual Pfizer-Chemistry Symposium Friday, May 11, 2007 1908 Chemistry Building Birthday Banquet Celebration Friday, May 11, 2007 1st Annual UM Chemistry Research & Education Symposium Saturday, May 12, 2007

Details will be posted on the Chemistry Department website at http://www.umich.edu/~michchem

1988 Chemistry Building

Florence Fenwick Outstanding Graduate Student Graduate Program News Instructor Award Presented to Graduate students who taught undergraduate courses Graduate Student Awards 2005 & 2006 in Chemistry during the 2004-05 and 2005-06 academic years. Winners are chosen by their contribution to innovation in the lab Departmental Awards or classroom, teaching evaluations, and faculty recommenda- tions. These awards are provided from the Florence Fenwick American Chemical Society Outstanding Graduate Memorial Fund. Student Award for Research and Teaching 2005 – Mehmet Karabiyik (James Penner-Hahn) This award is given by the Huron Valley Section of the American 2006 – Jiong Yang (Kristina Hakansson) Chemical Society. It is intended to recognize achievement in teaching and research by a Graduate Student. Wirt & Mary Cornwell Outstanding Graduate Student 2005 – Christopher Price (Adam Matzger) Research Award 2006 – Jun Pan (Arthur Ashe) Presented to Graduate students based on research advisor recom- mendation, publications, posters, meetings presented at, unique- ness of research and nature of research. These awards are provided from the Wirt and Mary Cornwell Prize.

 2006 2005 – Amelia Fuller (Anna Mapp), Christopher Price Novartis Graduate Fellowship in Organic Chemistry (Adam Matzger) 2005 – Kami Hull (Melanie Sanford) 2006 – Qi Zhang (Hashim Al-Hashimi), Xiaoyun Chen (Zhan Chen) Pfizer Graduate Fellowship in Organic Chemistry 2005 – Joshua Ney (John Wolfe) Milton Tamres Outstanding Teaching Award This award was provided by one of our emeritus faculty, Profes- Rackham One-Term Dissertation Fellowship sor Milton Tamres. The award recognizes outstanding cumulative teaching service. 2005 – Anthony Boitano (Gary Glick), Sara Woodcock (Zhan Chen) 2005 – Mehmet Karabiyik (James Penner-Hahn) 2006 – Katherine Plass (Adam Matzger), Jana Sefcikova 2006 – Julie Adamson (Kristina Hakansson) (Nils Walter), Xiaoyun Chen (Zhan Chen), Randy Lamber- tus (Richard Sacks) Robert & Carolyn Buzzard Graduate Chemistry Student Leadership Award Rackham Pre-Doctoral Fellowship The Leadership Award is given to a graduate student who has 2006 – Matt Clarke (Zhan Chen), Cheryl Loch (Zhan Chen) shown the skills of a leader. The person takes an active role in the Department - assisting with graduate recruitment; working Regents Fellowships with faculty and staff to provide a better environment for gradu- ate students; also serves as a morale and welfare support person. 2005 – Timothy DeVries (Edwin Vedejs), Trisha Duffey This award is provided by Bob and Carolyn Buzzard. (Edwin Vedejs), Stephanie Gantt (Carol Fierke), Jonathan Mortison (David Sherman), Jesse Ward (James Penner- 2005 – Jennifer Cunliffe (Robert Kennedy) Hahn), Nissa Westerberg (Carol Fierke) 2006 – Amy Payeur (Robert Kennedy) 2006 – Stephanie Gantt (Carol Fierke), Jesse Ward (James Penner-Hahn), Jonathan Mortison (David Sherman), Anna Dow Chemical Company Summer Support Award Clark (Robert Kennedy) This award is for a first year graduate student who has shown special promise doing research. 2006 – Matthew Leathen (Anna Mapp) Non-Departmental Fellowships Eastman Chemical Company Focus School Fellowship Seyhan Ege ADVANCE Travel Awards 2006 – Julie Adamson (Kristina Hakansson) The ADVANCE Travel Awards are given to female students who are interested in an academic career and will be attending a conference. Hertz Foundation Fellowship 2005 – Sarah Buhrlage (Anna Mapp), Angela Fleischhacker 2005 – Katie Mitchell-Koch (Adam Matzger) (Rowena Matthews), Paweena Kreunin (David Lubman), Katherine Plass (Adam Matzger), Wei Tang (Raoul Kopel- Link Foundation Fellowship man), Hui Wei (Robert Kennedy) 2005 – Jesse Rowsell (Omar Yaghi) Departmental Fellowships Bristol-Myers Graduate Fellowship National Aeronautics and Space Administration Fellowship 2005 – Thomas Dineen (William Roush) 2006 – Lopa Desai (Melanie Sanford) 2005 – Steven Rowe (Anna Mapp)

Eli Lilly Graduate Fellowship National Science Foundation (NSF) Fellowship 2005 – Allison Dick (Melanie Sanford), Jana Sefcikova 2005 – Maria Rhodes (Walter), Thomas Sundberg (Gary (Nils Walter), Jonathan Shackman (Robert Kennedy) Glick) 2006 – Xiaoyun Chen (Zhan Chen), Jeremy Holtsclaw 2006 – Kami Hull (Melanie Sanford), Thomas Sundberg (Masato Koreeda), Allison Dick (Melanie Sanford), John (Gary Glick) Hoerter (Nils Walter) Natural Sciences & Engineering Research Council of Margaret and Herman Sokol Graduate Fellowship in Canada Fellowship Chemistry 2005 – Jennifer Cunliffe (Robert Kennedy) 2005 – Stephen Caskey (Marc Johnson) 2006 – Jennifer Cunliffe (Robert Kennedy)

U-M DEPARTMENT OF CHEMISTRY  Rackham Merit Fellowships Kennedy), Andrea Dawson (Marc Johnson), Alex Hansen 2005 – Tara Lynn Conser (James Coward), Joseph Gallegos (Hashim Al-Hashimi), John Henssler (Adam Matzger), (Anthony Francis), William C. Johnson (Zhan Chen), Re- Kami Hull (Melanie Sanford), Alan Kiste (Brian Coppola), becca Tinsley (Nils Walter), Ricardo Lira (William Roush), Pascale Leroueil (Mark Banaszak Holl), Rajan Pragani Zikiya Norton (Anna Mapp), Lidaris SanMiguel (Adam (William Roush), Kendra Reid (Robert Kennedy), Shaelah Matzger), Salena Whitfield (Melanie Sanford) Reidy (Richard Sacks), Randon Walker (Mark Banaszak- 2006 – Frank Vazquez (Eitan Geva), Michael Orozco Holl) (Roseanne Sension), Zikiya Norton (Anna Mapp), Lidaris 2006 – Andrea Geyer (Marc Johnson), John Henssler San Miguel (Adam Matzger) (Adam Matzger), Jody Canapp (John Wolfe), Anne Desim- one (Zhan Chen), Elizabeth Dethoff (Hashim Al-Hashimi), Rackham Science Awards Nicolette Guthrie (John Wolfe), Andrew Higgs (Melanie Sanford), Alan Kiste (Brian Coppola), John Nelson (Ed- 2005 – Max Bailor (Hashim Al-Hashimi), Christopher win Vedejs), Matthew Remy (Melanie Sanford), Grant Cabello (Vincent Pecoraro), Anette Casiano (Hashim Al- Sormunen (John Montgomery), Jessica Stover (Kevin Hashimi), SusAnn Winbush (William Roush) Kubarych), Laura Zimmerman (Mark Meyerhoff) 2006 – Nicholas Ball (Melanie Sanford), Max Bailor (Hashim Al-Hashimi), Anette Casiano (Hashim Al-Hashi- Molecular Biophysics Training Program (MBTP) mi), Christopher Cabello (Vincent Pecoraro) 2005 – John Hoerter (Walter), Miguel Pereira (Walter) Sloan Fellowship 2006 – Catherine Musselman (Hashim Al-Hashimi), Jesse Ward (James Penner-Hahn) 2005 – Francisco Vazquez (Eitan Geva), Salena Whitfield (Melanie Sanford) Pharmacological Sciences & Biorelated Chemistry 2006 – Ryan Casey (Anna Mapp) Training Program (PSTP) Sokol International Summer Research Fellowship in 2005 – Heather Hartman (Fierke) the Sciences 2006 – Amberlyn Wands (Anna Mapp) 2005 – Curtis Schneider (Vincent Pecoraro)

Training Grants Cellular Biotechnology Training Program (CBTP) 2005 – Kristin Smith (Fierke) 2006 – Tamiika Hurst (Carol Fierke), Kristin Smith (Carol Fierke), Claire Chisolm (Robert Kennedy)

Chemistry-Biology Interface Training Program (CBI) Training Grant provided by National Institutes of General Medical Sciences for research at the interface of chemistry and biology. Includes units of Chemistry, Biological Chemistry in the Medical School and Medicinal Chemistry in the College of Pharmacy. 2005 – Sara Buhrlage (Anna Mapp), Christopher Cabello (Vincent Pecoraro), Susan Deeter (Edwin Vedejs), Lindsey Gottler (Neil Marsh), Robert Rarig (Edwin Vedejs), Curtis Schneider (Vincent Pecoraro) 2006 – Sarah Buhrlage (Anna Mapp), Christopher Cabello (Vincent Pecoraro), Curtis Schneider (Vincent Pecoraro)

Graduate Assistants in the Area of National Need (GAANN) Enhance teaching and research capacities of chemists to meet the needs of emerging industries vital to our technological com- petitiveness and to supply our colleges with faculty to meet the 21st Century teaching and research missions. 2005 – Robert Bates (William Roush), Andrew Boughton (Zhan Chen, Ioan Andricioaei), Claire Chisolm (Robert

10 2006 Graduate Degrees - Masters & Ph.D

Doctorates for August, December, 2004 Cao, Youfu Kopelman, Raoul Developing Optical Ratiometric Nanosensors/Nanoprobes for Chien, Tun-Cheng Townsend, Leroy B Biomedical applications. Design, Synthesis and Biological Evaluation of Imidazo[4,5- c]pyrazole Nucleosides as 5:5 Bicyclic Analogs of Purine Chen, Bin Mapp, Anna K. Nucleosides. I. Methodology Development for the Synthesis of Geminally Disubstituted beta-Amino Acids, beta-Proline Analogs and Harris, Dinari A Walter, Nils G Allylic Amines. II. Progress Towards the Synthesis of An Arti- Conformational Changes and Metal-Ion Binding in the Hepa- ficial Transcription Activator. titis Delta Virus Ribozyme. Cheng, Mou-Chi Marsh, E. Neil G. Hering, Kirk William Pearson W.; Marletta, Michael Mechanistic Studies of Adenosylcobalamin Homolysis in Glu- I. The Synthesis of YC-1 Analogues for a Photoaffinity Study tamate Mutase. of Soluble Guanylate Cyclase. II. Synthesis of Kifunensine and Analogues as Inhibitors of Endoplasmic Reticulum Alpha Crane, Nicole J Morris, Michael D Mannosidase I. Raman Microspectroscopic Studies of Normal and Pathological Musculoskeletal Tissues. Stoy, Patrick Pearson,William I. Completion of the Synthesis of Kopsia Lapidi- Dietz, Amber L Pearson, William lecta Alkaloid(?)-Lapidilectine B. II. Synthesis of 1- I. Synthesis of N, N-Bis(3-Butenyl)Amines from (2- Azabicyclo[N.3.0]alkanes via[3 + 2] Cycloadditions of Azaallyl)Nitriles.II. Synthesis of Highly Substituted Pyrroli- Nonstabilized Azomethine Ylides. zidines from Cyclic CarbinolAmides. III. Synthesis of Poten- tial Phototriggered DNA Crosslinking Agents. Hartman, Heather Lynn Fierke, Carol A Doctorates for May, December 2005 Protein Farnesyltransferase and Protein Geranylgeranyltransfer- ase Type I: Metal Requirements and Substrate Specificities. Buchanan, Stacey Anne Meyerhoff, Mark E. Jameson, Emily Elizabeth Polyion-Sensitive Membrane Electrodes: Fundamental and Kennedy, Robert T. Applied Studies. Probing Bioaffinity Interactions by Capillary Electrophoresis: Application to G Protein Signaling. Cao, Ganfeng Marino, Joseph; Koreeda, Masato Jeong,Sohee Development of a New Strategy for the Enantiospecific Syn- Fierke, Carol A thesis ofAspidosperma Alkaloids: Total Syntheses of Aspido- Functional Assemblies of Nanocrystal Quantum Dots on spermidine andAspidophytine. M.icrotubule Scaffolds.

U-M DEPARTMENT OF CHEMISTRY 11 Kuntzleman, Thomas Scott Yocum, Charles F. Rapid Electrophoresis-Based Immunoassays on a Microfluidic Redox Chemistry of the Calcium-Manganese Cluster of Photo- Chip. system II as Probed by Chemical Reducing Agents. Sudik, Andrea C Yaghi, Omar M Kravitz, Joslyn Y Carlson, Heather; Pecoraro,Vincent Design, Synthesis, Characterization, and Sorption Proper- Computational Studies of the Vanadium Dependent Haloper- ties ofMetal-Organic Frameworks and Polyhedra based on 0/+ oxidase and Vanadyl-imidazole Complexes. [Fe3O(RO2)6L3] Clusters. Lewis, Kevin D Matzger, Adam J. Sumner, James Patrick Kopelman, Raoul Bergman Cyclization of Sterically Hindered Subtrates and Development and Characterization of PEBBLE Nanosensors Cycloaromatization of Diethynyl Sulfides. for Transition Metal Ions. Libardoni, Mark Jeffrey Sacks, Richard D Westerberg, Nissa M Fierke, Carol A Design, Development and Evaluation of a Resistively-Heated Protein Based Fluorescent Biosensors for Small Molecule Thermal Modulator for Comprehensive Two-Dimensional Gas Analytes:Development, Optimization and Use. Chromatography. Wilson, Erin Elizabeth Beck, Larry W. Liu, Christopher Matthew Roush, William R. Determination of Structure in Heterogeneous Solids using Studies in Acyclic Diastereocontrol. I. Investigations into the Heteronuclear Dipolar Coupling Solid State NMR. TransitionStates of the Methyl Ketone Aldol Reaction and II. Wilson, Mark V Beck, Larry; Sacks, Richard Studies Towards the Total Synthesis of Durhamycin A. Measurement of Quadrupolar Coupling Strength of Metals in McCarrick, Robert M Yocum, Charles F. Zeolite Materials. Characterization of the Reaction Between N, N, N’, N’-Tetra- Woodcock, Sara E Chen, Zhan methyl-P-Phenylenediamine (TMPD) and the Photosystem II Interfacial Studies of Polymers and Proteins with Atomic Mn Cluster. Force Microscopy. McGuigan, Megan E Sacks, Richard D Zaleski,Curtis M Pecoraro, Vincent L. Optimization and Application of Selectivity Enhancement Utilizing Metallacrowns to Develop New Single-Molecule Techniques for GC Separations using Series-Coupled Dual Magnets. Column Ensembles. Zheng, Nan Roush, William R. Ockwig, Nathan W Yaghi, Omar M I. Total Synthesis of Concept Molecule (CM) II. Progress Development and Illustration of a Unified Conceptual Fram. Towards the Total Synthesis of Pectenotoxin 2. ework for the Design of Extended Metal-Organic Structures. Park, Edwin Jay Kopelman, Raoul Optical PEBBLE Nanosensors and Fiber Optic Sensors for Doctorates for May 2006 Real-time Intracellular Imaging and Analysis of Magnesium Buchanan, Nathan S Lubman, David M. and Oxygen. Studies of Human Breast Cancer Utilizing Two-Dimensional Peng, Hailin Kopelman, Raoul Liquid Separations and Mass Spectrometry Reaction Kinetics in Low-Dimensional Diffusion-Limited Chen, Tso-Ching Morris, Michael D. Systems: Experiments and Simulations. Raman Spectroscopy for Study of Genetic and Metabolic Dis- Price, Christopher Patrick Matzger, Adam J. orders of Bone Tissue. Methods for and Implications of Controlling Solid Form in Haines, Brian Michael Gland, John L. Organic Crystals. Catalytic Hydrodechlorination of Chlorinated Aromatics on the Rowsell, Jesse Yaghi, Omar M. Pt(111)Surface. Hydrogen Storage in Metal-Organic Frameworks: An Investi- Millward, Andrew R Yaghi, Omar M gation of Structure Property Relationships. Adsorption of Environmentally Significant Gases (H2, CO, Schaefle, Nathaniel John Sharp, Robert R H2S, CH4) in Metal-Organic Frameworks Nuclear Magnetic Resonance Paramagnetic Relaxation: Influ- Peris, Gorka Roush, William; Vedejs, Edwin ence of the Electron Spin Energy Level Structure. Asymmetric Synthesis of the Quaternary Carbon of the Dia- Scheideman, Matthew Howard Vedejs, Edwin zonamides. Heteroatom-Directed Intramolecular Hydroboration using Acti- Tinsley, Rebecca Ann Walter, Nils G. vated Borane Complexes. Probing the Structure-Function Relationship of Two Non-Cod- Shackman, Holly Merideth Kennedy, Robert T. ing RNAs: The Hepatitis Delta Virus Ribozyme and glms Advances in Capillary Liquid Chromatography - Multi-Stage Catalytic Riboswitch. Mass Spectrometry for Online Monitoring of Neuropeptides Williams, Paul Douglas Goldstein, Richard A. and Neurotransmitters in Dialysate. Evolutionary Insights into Protein Structure, Stability, and Shackman, Jonathan G Kennedy, Robert, Functionality. Monitoring Hormone Release from Islets of Langerhans via Zheng, Suping Lubman, David M. Proteomic Methods Development and Analysis of Proteomic

12 2006 Response of Psychrobacter 273-4 and Escherichia Coli in Ex- Hay, Michael Bryan Wolfe, John treme Environments. Mo, Jingjie Hakansson, Kristina Zhu, Yi Lubman, David M. Ney, Joshua Edward Wolfe, John The Development of the 2-D Liquid Phase Mass Mapping SanMiguel, Lidaris Matzger, Adam Method as a Proteomic Approach and its Applications in Can- Bartolin, Jeffrey Banaszak Holl, Mark cer Study. Gottler, Lindsey Marie Marsh, E Neil Hansen, Alexandar Louis Ramamoorthy, A. Lewis, Kevin D Matzger, Adam Masters - August, December, 2004 Musselman, Catherine Anne Andricioaei, Ioan; Al-Hashimi, Hashim Liu, Christopher Matthew Roush, William Rowsell, Jesse Yaghi, Omar Va, Porino Jinjo Roush, William Masters - May, 2006 Wildon, Antony Ross Vedejs, Edwin Dishinger, John Francis Kennedy, Robert Yang, Jiong Kennedy, Robert Gawlik, Gayle Marie Mapp, Anna Zhao, Jia Lubman, David Hunt, Kathryn Sensenig Haldar, Suranjana Penner-Hahn, James Kristalyn, Cornelius Bruce Chen, Zhan Li, Jingjing Woodard, Ronald Nakhla, Josephine Saad Wolfe, John P Touw, Debra S Pecoraro, Vincent Payeur, Amy Lynn Meyerhoff, Mark.; Sacks, Richard Masters - May, August, December, 2005 Pei, Jian Kennedy, Robert Davidson, Joseph David Ashe III, Arthur Wang, Lin Coucouvanis, Dimitri Desai,Lopa Vrushank Sanford, Melanie Ward, Jesse Dylan Penner-Hahn, James Grzesiak, Adam Leo

Organic Symposium, October 16, 2006 raiser, a department wide “penny war”. In the penny war each student class, the staff, and the faculty competed against each David Madar (BS, 1992) from Abbott Laboratories and David other to see who could collect the most pennies. Water jugs were Collum from Cornell University were the industrial and academic put out for 4 weeks to collect each team’s pennies. Additionally speakers at the department’s organic mini-symposium on Oct. by putting non-penny currency into another team’s jug one could 16, 2006. The event is underwritten by Abbott Laboratories. bring their score down. The staff won followed closely by the Graduate students Ms. Dipa Kalyani (Sanford group) and Mr. first year students and graciously donated the price of their prize Josh Ney gave outstanding oral presentations. Dipa spoke on to the proceeds. We had a great time and were able to raise $800 new approaches in C-H bond activation using a Pd(II)/Pd(IV) for the department, which went to the Richard D. Sacks Memo- catalytic cycle. Josh talked about his work on developing new rial Travel Award fund. We received great feedback and hope to Pd-catalyzed syntheses of nitrogen heterocycles. Chemistry hold this event annually. graduate students won four prizes for poster presentations. First prize: Adam Grzesiak (Matzger group), “Application of In the spring we held an ice cream social in conjunction with Polymer-Induced Heteronucleation to the Polymorphic Analge- the student awards ceremony, and during the summer organized sics Flurbiprofen and Sulindac. “Second Prize: Trisha Duffey a staff appreciation day to honor our great staff for all of their (Vedejs group): “Chiral Nucleophilic Catalysis: Synthesis and hard work. We also sponsored a student trip to a Tigers game Rearrangement of O-acylated oxindoles”. Third prizes: Gayle this summer. We coupled the baseball game with a canned-food Gawlik (Mapp group): ‘Triplex-forming Oligonucleotide-based drive collecting 150 cans of food which were donated to the Food Artificial Transcriptional Activators”. Nick Ball (Sanford group): Gatherers. We continued our big sib/little sib program this year “Palladium-Catalyzed Fluorination and Trifluoromethylation of in which senior students are paired up with incoming students to Carbon-Hydrogen Bonds”. provide support during their transition to Ann Arbor and graduate school, and during new student orientation organized lunches between the big and little sibs. And of course, this fall we held our annual barbecue to start off the semester and welcome the Graduate Student Council News new students into the department. The graduate student council (GSC) organizes several events This year the GSC Officers and Representatives were Allison for the chemistry department throughout the year to support the Dick, Andrew Higgs, Catherine Musselman, Claire Chisolm, Chris student body and reach out to the community. This year one of Avery, Gayle Gawlik, Jody Canapp, Jennifer Cunliffe, Kendra our goals was to provide an avenue for students to get involved in Reid, Matthew Leathen, Marisa Macnaughtan, Nick Cellar, Amy department fundraising at a level they could afford. Thus, at the Payeur, and Meagan Wagner. start of the year we put together our first ever departmental fund

U-M DEPARTMENT OF CHEMISTRY 13 Undergraduate Program News For the past 16 years, the University of Michigan has invited students from around the country to spend a summer on campus Research Experience for Undergraduates working closely with faculty and graduate student mentors, con- (REU) Program ducting research in their area of interest. The REU program is an excellent way to reach into the student talent pool and encourage The National Science Foundation creates opportunities for the participation in chemical research of women, underrepresented undergraduates to join research projects each summer. One minorities, persons with disabilities, and students from institu- of the principle vehicles of NSF support for such projects is tions where research opportunities may be limited. through the Research Experience for Undergraduates (REU) The Department of Chemistry provides abundant opportuni- program. ties for individuals to work in tandem as researchers, educators, The REU program involves students in ongoing research proj- and students, engaged in joint efforts that encourage educational ects and proposals being conducted at the University of Michigan, discovery through a range of learning perspectives. The REU and thus allows them to experience first-hand how basic research program reflects the Department’s conviction that collaborative is conducted at an internationally prestigious university. intellectual relationships are an essential component of success- ful learning experiences. Dr. Brian P. Coppola coordinates the Department’s REU program, which runs for 10 weeks during the summer. Dr. Melanie Sanford is the co-PI on the NSF project. In response to the increasing requests from non-U.S. citizens for summer research experience such as the REU program provides, the UM Rackham Graduate School this year provided matching funds to bring two such undergraduate researchers onto campus in an expansion of the traditional program.

Summer 2005 Student Home University Advisor Felix Chavez University Incarnate Word Sherman Albert Coombs Kenyon College Al-Hashimi Sean Gant University of Michigan Banazak Holl Ashley Garner Texas Southern University Woodard Christopher Grant University of Michigan Vedejs Steven Harris Langston University Mapp Stephen Leonard Indiana Wesleyan Univ. Coward Dalvin M. Hernández Universidad Metropolitana Matzger James Patterson Indiana University Walter Jennifer Reece Grinnell College Sacks Norma Iris Rodriguez U of Puerto Rico-Mayaguez Coward Josephine S-Tenkoramaa College of Wooster Matzger Christen Strollo Muhlenberg College Kopelman Abbey Sjogren Saint Cloud State Univ. Pecoraro

Summer 2006 Student Home University Advisor Alexander Buck Northern Michigan Univ. Carlson Matthew Elliott Auburn University Meyerhoff Sabrina Wells Truman State University Meyerhoff Dalvin Mendez University Metropolitana Matzger Lindsay Fay Kettering University Goodson Vanessa Guzman Stanford University Sanford Rosaura Padilla Colorado Springs Wolfe Julia Silveira University of Rochester Coward Marsha Ng Univ. Hawaii Andricioaei Hannah Burleson Catawba College Hakansson

14 2006 Undergraduate Awards

2005–2006 Seyhan Ege UG Research in Chem Sarah Isquick (Glick) AIC/Alumni Biochemistry Award Honors College Vanko Award 2005 – Lev Prasov (Mapp) 2005 – Sanyo Tsai (Coward) 2006 – Amber Warnat (Schacht) 2006 – Bethany Schroeder (Sherman) AIC/Alumni Chemistry Award Barry M. Goldwater Scholar 2005 – Rebecca Farmer (Townsend) 2005 – Eric Chanowski (Coppola) 2006 – Andy Tsai (Matzger) Florence Fenwick Memorial Alpha Chi Sigma (AXE) Outstanding First Year Student Award 2006 – Ashley Tan (Penner-Hahn) Florence Fenwick Memorial Scholarships 2005 – Katie Lutker 2006 – Sarah Carmen 2005 – Lara Czabaniuk, Amber Warnat American Chemical Society (ACS) Analytical Chemistry 2006 – Alan Commet (Yocum), Lara Czabaniuk (Koreeda) Award Florence Fenwick Outstanding Senior Award 2005 – Andy Tsai (Matzger) 2005 – Alan Poon, Zachary Tolstyk 2006 – Keary Engle (Matzger) 2006 – Andy Tsai (Matzger), Jia Wang (Banaszak Holl), American Chemical Society (ACS) Huron Valley Amber Warnat (Schacht) Section Outstanding Senior-Leadership Award Lubrizol Scholarship 2005 – Costas Lyssiotis (Glick) 2005 – Kathryn MacKool (Koreeda) 2006 – Alison Hardin (Wolfe) 2006 – Justin Lomont (Coppola) Alumni Achievement Awards Margaret and Herman Sokol Scholarships 2006 – Elise Jeffrey 2005 – Meghan Dubois, Justin Lomont Alumni Achievement Award Outstanding First Year 2006 – Yihe (Yao Yao) Guan (Glick), Samuel Eaton, Sarah Carmen, Tiffany Chen (Koreeda), Osman Yilmaz (Mat- Student thews) 2005 – Andrew Kim, Justin Lomont, Corina Mommaerts, National Starch Scholarships Sara Na 2006 – Grace Lee, Kurun Oberoi, Rebecca Kow, Jeffrey 2005 – Andy Tsai (Matzger), Osman Yilmaz (Matthews), Simon Alice Zheng (Schacht) 2006 – Marty Tam (Koreeda), Kathryn MacKool (Kore- Alumni Achievement Award Outstanding Second Year eda), Katherine Kurnit (Saper) Student Pfizer Synthetic Organic Scholarship 2005 – Susie Chen 2006 – Hana Russo 2005 – Kathryn MacKool (Koreeda) Alumni Achievement Award Outstanding Third Year Merck Index Award to Outstanding Seniors Student 2005 – Kevin Hagedorn (Yaghi), Luke Janik (Fierke), 2005 – Xin Li Bethany Percha, Ralph Petty III (Uhler), Todd Senecal 2006 – Osman Yilmaz (Matthews) (Koreeda) 2006 – Gloria Jih (Ballou) , Henry Lu (Fierke), Eric Cha- Alumni Achievement Award Outstanding Senior nowski (Coppola), Melinda DeSantis (Kaufman), James Student Mainero (Rasmussen), Jia Wang (Banaszak Holl) 2006 – Carissa Orizondo (Uhler) CRC Outstanding Freshman Achievement Award 2005 – William Geisert Summer Research Awards 2006 – Christina Krokosky Alumni Award Jerome & Isabella Karle Natural Science and Math 2005 – Alice Zheng (Schacht), Xin Li (Koreeda) Prize Nominee (Honors) 2006 – Robert Clarren (Wolfe) 2005 – Lev Prasov (Mapp), Rebecca Farmer (Townsend) David W. Stewart Memorial Sidney Fine Teaching Prize Nominee (Honors) 2006 – Nicholas Preketes (Geva) 2005 – Costas Lyssiotis (Glick) Dow Chemical Company Seyhan N. Ege - WISE Award 2005 – Daniel Tai (Pecoraro) 2005 – Melissa Gondert (Walter) 2006 – Walter Haberaecker (Koreeda) 2006 – Andrea Haber (Glick)

U-M DEPARTMENT OF CHEMISTRY 15 Gomberg Scholarship Margaret & Herman Sokol Endowment 2005 – Cindy Lin (Menon), Milad Sharifpour (Coppola) 2005 – Waseen Anani (Sanford), Lara Czabaniuk (Koreeda) 2006 – Justin Lomont (Coppola), Katie Lutker (Matzger) 2006 – Chelsea Durgan (Ballou) Gomberg Alumni Award PPG Scholarship 2006 – Tiffany Chen (Koreeda), Alan Commet (Yocum) 2005 – Barry Leonard (Johnson), Robert Dood Jr. (Johnson) James E. Harris Scholarship 2006 – Gloria Lee (Marsh), Kathryn MacKool (Koreeda) 2005 – Andrea Haber (Glick), Jia Wang (Banaszak-Holl) Walter R Yates 2006 – Yihe (Yao Yao) Guan (Glick), Brian Haber (Ninfa) 2005 – Eric Chanowski (Coppola), Osman Yilmaz (Mat- Eli Lilly Organic thews) 2005 – Walter Haberaecker (Koreeda) 2006 – Whitney Carlson (Pecoraro), Rahul Neogi (Rama- moorthy)

16 2006 Bachelors Degrees August, December, 2004 and May, 2005

Chemistry Matthew Tennis Geoffrey Giarmo Ralph Petty III Amina-Louise Asabigi Zachary Tolstyka Zubair Giga Mary Pinter Stephen Chung Eric Watt Melissa Gondert Alan Poon Rebecca Farmer Brian Wiers Bianca Gruber Sahand Rahnama-Moghadam Richard Fredricks Sarah Zeile Amy Harlow Krishna Rangarajan Adrian Gasperut Katharine Heeringa Kara Rudolph Andrew Getsoian Biochemistry Anna Hodges Michael Schoonover Ian Gifford Eseroghene Agari Luke Janik Janice Shih Landon Greene Uzoma Anyanetu Austin Johnson Erin Shovlin James Haskins IV Ebinehita Arhebamen Arieh Kestler Alexander Shune Steven Kaneti Matthew Bai Jonathan Lee Neil Sink Rami Kassis Jeremy Berman Suheung Lee Jordan St Charles Karen Kehbein Kyle Bolduc Angela Liang Ellen Swenson Falen Lockett Rachelle Caoagas Costas Lyssiotis Jennifer Szabo David Mitchell Brantley Carlson Juie Mahajan Sanyo Tsai Robert Murphy Jacob Carlson Mark McCubbin Ramona Vanel Julie Pannuto Tracy Chapman Michael Oleyar Vitaly Volberg Amy Putin Kenny Chen Michael Palte Jeffrey Wargo Kathleen Rainey Joseph Colombo Bhumit Patel Natalie Wolters Joel Schrauben Elizabeth Cooper Dilesh Patel Yun Xie Todd Senecal Ken Gelhaus Ravi Patel Wee Sing Yek

December, 2005 and May 2006 Graduates

Chemistry Andy Tsai Cindy Lin Eirwen Scott Amina-Louise Asabigi Henderson Williams Yi Liu Sheryl Serbowicz Maxim Burgman Jason Wong Henry Lu Daniel Son Eric Chanowski Rebecca Lynch Michael Song Mun Choe Biochemistry Nick Mank Alexandria Suchy-Mabrouk Christopher Cornelio Shailesh Agarwal Seyedeh-Neda Moezzi Marty Tam Dawn Cushman Olga Astapova Madani Amber Warnat Raquel Daboul Matthew Bai Brett Mollard Marc Witcher Richard Fredricks Maxim Burgman Andrew Scarpelli Stephen Zins Anshu Giri James Carson Bethany Schroeder Christopher Grant Han Chang Jason Grunewald Eric Chanowski Kush Gulati Dharmraj Chauhan Andrea Haber Divya Chillapalli Niles Harding Courtney Crocket David Hucul Raquel Daboul Erin Larkspur Melinda DeSantis Barry Leonard Latoyia Floyd James Mainero Amanda Gomez Kate Mazur Eric Holmberg Scott Milam Gloria Jih Melissa Osquist Paul Johnson Sanjaykumar Ramoliya Joseph Kenwabikise Derek Rothhaar Akihisa Kimura Andrew Scarpelli Benjamin Lack Amy Taylor Eric Liao

U-M DEPARTMENT OF CHEMISTRY 17 Joseph and Alfreda Shepard Lynn Dean Hawkins Edwin Vedejs Gifts Kristi D. and Hilary E. Snell Steven P. Henry Paul Denzle Walker Graham Stewart Rebecca D. Henry Steven and Susan Zawacky Contributions from private Clarke and Ann Swayze Roland Hirsch CSIE-Coppola; Teaching Award and corporate donors re- Jack Sweet James and Linda K. Holcombe Walter and Audrey Syrkowski Walter M. Holloway Gift ceived from July 1, 2004 Lazarus Thomas Jeffrey D. Hsi Frederick C. Matthaei – June 30, 2006 3M Corp.* Johnson & Johnson Fund* Departmental Scholarships (* Indicates corporate match- Kelly Bruce Triplett Harold Kohn Richard Bard Robert C. Tripp Paul Martin Kovach Randel and Ann Little ing funds.) Howard Un James and Jeanne Lagowski Timothy F. Merkel William KC Wong Lockeed Martin Co.* Valero Energy* Metropolitan Life Fdn.* Bachmann Memorial Lecture Alumni Discretionary Fund Richard W. Loeppky Gomberg Lecture Series Alice Carlson Norman and Isabelle Arends Annabel Muenter E.I. Dupont DeNemours & Company Robert A. Gregg John Bauman Irvin W. Potts Arthur C. Stevenson James E Harris Scholarship Timothy G. Bee Russell E. and Margaret G. Price Fund In Chemistry Rene Bergero Walter E.F. Rupprecht Chair’s Discretionary Fund Marian Harris J.M. Goldberg and B.J. Burroughs Mark M. and Jane Banaszak Holl James M. Samanen Cargill, Inc.* Diane H. Burley Klaus Schmiegel Membrane Biophysics Sympo- Thomas Caughey John J. and Rosemary J. Callahan Jack Sweet sium S. Thomas Cleveland Alice S. and Allen F. Corey Ching-Leou and Kelly Teng Aldrich Chemical Company, Inc. Alice S. Cohen Comcast Corp.* James Hunter Thirtle Bruker Biospin Corporation Eunice Fraser Connors Lyubica Dabich Lazarus D. Thomas Spectra Gases, Inc. Alice S. Corey R. R. Damrauer John K. Tomlinson Varian, Inc Frederick Crane Carol Ann Fierke Veronica H. Wiley Sue and John Delos David J. Hart Joel and Susan Wolfe Milton Tamres Teaching Award Richard and Judith Doyle Jerome and Isabella Karle William Koon Chong Wong, Trust Irving and Frances Adler Dow Chemical Co. Foundation* Masato and Koko Koreeda Paul F. Zittel Marjorie and Donald Carter Dow Corning Co.* Robert L. and Ann E. Kuczkowski Other Vincent P. and Roxanne M. Drnevich Eli Lilly & Co.* Chemistry Dept. - Library John Callen Sheldon Shore David and Patricia A. Ebdon Antone L. Lott II Stephen L. Gaudioso Michele Green Eickholt Lucian J. Philion Estate PECRUM Symposium Janet C. Haartz P. L. and Helen Fan The P&G Fund* DuPont Automotive Irene C. Piscopo Larry Fink Edwin and Roberta Przybylowicz Pfizer James and Christine Sabatowski Howard S. and Lori M. Friedman Daniel J. and Jean L. Ricca Peter A.S. Smith Fellowship Ralph E. Friedrich Xerox Foundation* Erich and Suzanne E. Schulz Jerome Horwitz Scott and Jackie Funt Joseph W. and Elfreda Shepard Chemistry Graduate Fellowships Roy Pointer Phyllis H. Garland Clark E. and Ann I. Swayze Dorothy M. Dolfini Peter A.S. and Mary Walsh Smith Howard Garrett 3M Corp.* Eastman Chemical Foundation* Erich Gess Howard H. and Mary C. Un Richard D. Sacks Memorial Joel M. Goldberg Paul Zittel Chemistry Strategic Fund Student Travel Fund Michele Eickholt and Lee Green Thomas Adamson David R. Lisa M. Albers David Hart Chemistry - Special Scholarships Michael and Linda Balogh Balogh Stephen and Ruby Meis Brewer Kathy and Kurt Hillig American Chemical Society J. Dolf Bass Bonnie Fox Terrance K. Hilty BASF Steven and Juliana Boerio-Goates Lawrence and Elizabeth Holzman Thomas Houser Bristol-Myers Squibb Co. James L. Brewbaker James C. and Tindera M. MacBain IBM* John Campbell Jeanne A. Bucsela Mark E. Meyerhoff James and Irene S. Jackson CIBA Education Foundation Kathryn L. Burda Michael D. and Leslie J. Morris Marilyn Jacob Dow Chemical Co. Diane M. Burley Christer E. Nordman Theodore G. Jacob Eastman Chemical Foundation Dan L. Curtis Teng-Ke J. Pang Norman P. Jensen Eli Lilly & Co* Colleen M. DeKay Thomas Michael Rosseel Douglas and Sheryl Kalvin Lubrizol Foundatiom Virginia A. Dilkes James Windak and Patricia Bialkowski Phyllis E. Karseboom National Starch & Chemical Co. Fdn. David and Shirley Emerson Chemistry Department Staff Dominick and Carol Ann Labianca Novartis Institute for BioMedical Larry Fink Robert A. Landowne Research Bernam and Shirley S. Fraley Robert & Carolyn Buzzard Grad Antone Lott Pfizer, Inc. Charles Gallagher Chem Student Leadership George Lowrie PPG Industries Foundation Michael D. Gordon Robert B. and Carolyn A. Buzzard Kelly McGashen Proctor and Gamble* Mark T. Goulet Chemistry Dept Fund Milton and Dorothy Heller Robert Parry Scholarship Fund James D. McLean Charles Leona Heitsch Theodore and Phyllis Anderson Mark E. Jason Merck Co.* Karen W. and Joseph G. Morse BASF* Norman P. Jensen Monsanto Co.* Robert and Bonnie Paine Larry G. Bell Richard Hugh Kolloff John M. Moote Duward Shriver Betsey K. Blossey Robert and Ann Kuczkowski Amos Newton John and Mary Yoke Edward D. North Boeing Co.* Patty Laswick Walter and Ruth Ann Opdycke Albert E. Champney Ginny Shen Lin Margaret and Herman Sokol Gordon Parrington and Mary Ellen Heyde Ellen Tratas and George Contis E. Neil G. Marsh Fellowship James V. Pivnichny Renee I. Cribbins Monsanto Co.* Margaret Sokol Wayne and Carol Pletcher Gregg and Loraine Dieckmann Randolph K. Otto Rayber LLC * David and Priscilla A. Ebdon Carlton Placeway Willard Memorial Lecture Fund James and Jan Reh Elizabeth Hugel and Manfred Egerer Thomas Michael Rosseel Richard and Beverly Northrop Omar Robbins Kenneth and Anna C. Egger Helen S. Schaefer George and Dorothy M. Towe John C. Rosemergy Ralph E. Friedrich James and Judith Seydel Graham Stewart Morley and Maureen Russell Christopher Fulton Ginny Shen Lin Erich and Suzanne Schulz Thomas J. Giordano Merck Co.* John Vincent Scibelli Stewart E. Glover Claude F. and Louise W. Spencer Ronald Seamans Steven and Juliana Boerio Goates David R. Taylor Elaine G. Shafrin Thomas W. Gougeon Evelyn P. Tyner

18 2006 Alumni News Richard LeSar (BS, 1975; PhD 1981,Har- vard) left Los Alamos National Lab to E-Mail your news: [email protected] become professor and chair, Material Sci- Update your contact information: http://www.umich.edu/~michchem/alumni/ ences & Engineering, Iowa State Univ. If errors or misstatements are noted in any of the following items, the Editors of the Walter Maruszczak (BS, 1978) is a mar- Newsletter would appreciate such being called to their attention. Mistakes can, and do, ket development engineer at Ticona Co. inadvertently, creep in. Corrections can easily be inserted in the next edition. advancing the replacement of metal and metal alloys in vehicles with engineering Sultan Tawfiq Abu-Arabi (PhD 1982, Terrence Hilty (PhD 1981, Rudolph) is polymers and materials science. Ashe) is president of Tafilia Technical Global Manager of the Knowledgment Anderson Marsh (PhD 2003, Gland) is University in Tafilia, Jordan. He is president Management Group at Dow Corning in assistant professor of chemistry at Lebanon of the Jordanian Chemical Society and also Midland, MI. Valley College in Annville, PA. the Arab Union of Chemists. Morton Z. Hoffman (PhD 1960, Bern- James S. Mattson (PhD 1970, Mark) Irving Adler (PhD 1970, Brockway) is stein) received emeritus status at Boston graduated from the George Washington president of iMag, LLC. Irving is manager University after 44 years of service. Mor- University School of Law in 1971. He prac- Business Development North America for ton received the 2005 James Flack Norris ticed Environmental and Land Use Law in CRU International, a business intelligence Award for Outstanding Achievement in the Florida Keys for 22 years. He remains and marketing information firm in com- Teaching Chemistry from the Northeastern interested in the science-law interface. Section of the ACS. He will receive the modity materials. David Mendenhall 2007 National Award for Volunteer service (BS 1966) has retired Norman Arends (BS 1967; MBA 69, UNC) to the ACS in the spring 2007 ACS meet- as professor of chemistry at Michigan Tech has retired as president of Transatlantic ing in Chicago. University and is President of Eastern Technologies. He resides in La Bouexiere, Sources, Inc, doing custom synthesis. Jerome Horwitz (PhD 1950, Smith; PD, France. Richard S. Myers Bachmann) retired as Professor Emeritus, (PhD 1981, Groves) Michael Bury (MS 2006) is working for Internal Medicine, Karmos Cancer Insti- is Vice President for R&D, Performance GlaxoSmithKline in Philadelphia, PA. tute, Wayne State University School of Chemicals and Thermosets, Dow Chemical John A. Campbell (BS 1987; MD 1993, Medicine after 49 years of publishing (and Co in Midland, MI. MN). After three years as a Navy general not perishing). Jerome synthesized the Wayne Pletcher (PhD 1971, Wiseman) is medical officer, he went on to a neurosur- anti-AIDS drug AZT (GlaxoSmithKline) president and CEO of Minnesota Technol- gery residency at the Medical College of in 1964 hoping that it would be useful in ogy, Inc, a provider of business consulting Virginia and is now in private practice in cancer therapy. In 1985, the compound services. Jackson, TN. was found to be effective in slowing the Todd Ryder (MS 1996) completed his PhD Robert W. Carling (PhD 1975, Westrum) growth of HIV, the virus that causes AIDS, in chemistry at the University of Rochester is Director of the Physical and Engineer- demonstrating the serendipity of basic and is employed at a biotech company in ing Sciences Center at Sandia National research. Connecticut. Laboratories in Livermore, CA. Jeffrey Hsi (PhD 1990, Koreeda; JD Dana Shea (PhD 2000-02, Morris) is Ana- Charles R. Cornman (PD 1989-91, Pec- Rutgers) is a patent attorney and partner at lyst in Science and Technology; Resources, oraro) is Director, Formulated Products, Edwards Angell Palmer and Dodge, LLP. Science and Industry Division, Library of R&D, Grace Construction Products, W.R. He participated in a Town-Hall meeting Congress, Washington D.C. Grace and Co in Cambridge, MA. in January 2005 arranged by the GSC to discuss career alternatives. Sheldon Shore (PhD 1957, Parry) of Ohio Liping Cui (MS 2006, Hakansson) is State University will receive the 2007 ACS employed as Research Associate at Thera- David M. Johnson (PhD 2000, Rasmus- Award in Inorganic Chemistry sponsored vance, San Francisco, CA. sen) is assistant professor of chemistry at by Aldrich Chemical. the University of Texas, San Antonio. Pauline Farmer-Koppenol (MS 1999) is Aaron Small (PhD 2000, Pugh/Pecoraro) a Juris Doctor Candidate, Dec. 2006, UM Douglas M. Kalvin (MS 1970, Marino; has joined Luna Innovations in Blacksburg, Law School. After graduation she will be PhD 1985, Woodard) is senior research VA as a Senior Research Scientist. a patent attorney in Silicon Valley. chemist at Abbott Laboratories in Abbott Park, IL. John P. Snow (BS 1998; JD 2005) is a Stanley A. Forfa (BS Biochemistry, 1997) patent attorney at the firm of Leydig, Voit graduated from Michigan State University Mark Klemp (PhD 1991, Sacks) is assis- and Mayer, Ltd. in Chicago, IL College of Osteopathic Medicine. He is tant professor of chemistry at the University of Wisconsin, Marinette. Graham Stoner (BS, MS 1951; PhD Tu- pursuing an osteopathic internship and gen- lane, 1956) is semi-retired and teaching part- eral surgery residency at Botsford General Dominic A. Labianca (PhD 1969, Over- time at Houston Community College. Hospital in Farmington Hills, MI. berger), Professor of Chemistry at Brook- Susan K. Gregurick (BS 1987) is assistant lyn College of CUNY, is the recipient of professor of chemistry at the University of the 2005 Brooklyn College Award for Maryland, Baltimore County. Excellence in Teaching.

U-M DEPARTMENT OF CHEMISTRY 19 In Memoriam He served as mentor to many PhD graduate students, who have gone on to distinguished careers in academia, industry and gov- We saddened to announce the deaths of the following faculty, ernment laboratories. alumni, alumnae and friends of the Department. Professor Sacks was internationally recognized for his pio- neering work on analytical instrumentation. During the early part Richard D. Sacks, Professor of of his career, his research focused on novel atomic emission Chemistry, died peacefully at his spectroscopic methods including direct solid-sample elemental home in Ann Arbor on February analysis. In the 1970’s he developed exploding thin film platforms 11, 2006 after a courageous battle for solids analysis combining simplicity of sample introduction with cancer. He was 63. with unprecedented low detection limits. In the mid-1980s, he Sacks received his BS from the turned his attention to innovative approaches to high-speed gas University of Illinois in 1965, and chromatographic separations of complex mixtures of volatile his PhD from the University of organic compounds. His methodologies reduced measurement Wisconsin in 1969. He began his times for complex mixtures almost 100-fold and attracted great career as an assistant professor in academic and industrial interest, eventually leading to formation, Ann Arbor that same year and was with several of his students, of a spin-off company, Chromatofast promoted to associate professor in Inc., that commercialized instrumentation invented in the Sacks 1974 and full professor in 1979. He laboratory. In recent years he helped to lead efforts at the Univer- served the Chemistry Department sity to create wireless micro-analytical systems for environmental, as associate chair for graduate studies from 1987-1992. homeland security, and deep-space applications. During his career, During his 37 years as a faculty member, Sacks was an out- Prof. Sacks and his coworkers published more than 150 research standing educator, teaching students the principles of analytical papers on these topics. chemistry and instrumentation. Over this period, he was a driving Prof. Sacks is survived by his wife Kristine and his daughter force in modernizing the analytical chemistry curriculum. He Jenny. A public memorial service was held on March 9, 2006. The developed completely new courses on chemical instrumentation Richard D. Sacks Memorial Travel Award has been established at the undergraduate level and, at the graduate level, he intro- to support yearly travel awards for analytical chemistry graduate duced courses on electronic measurements and microcomputer students to present their research at technical conferences. control of instruments, as well as modern separations methods.

Margaret McCormick Sokol In 1962, Dr. Sokol joined the Bristol-Myers Company where died in New York City on June he organized the company’s international pharmaceutical program. 4, 2006. Margaret and her late In 1967, he was named President of the Bristol-Myers Company husband Herman were long time International Division. In 1976 Dr. Sokol became President of friends and benefactors of the the Bristol-Myers Company. He retired in 1981. Chemistry Department and the Margaret Sokol taught high school mathematics for 15 years University of Michigan. after graduation from Montclair State College. She then resigned Margaret and Herman Sokol her position to accompany her husband on all his world-wide trips, received their undergraduate over a period of 20 years. She was active in the alumni affairs degrees from Montclair State of the University of Michigan, New York University and Mont- College in New Jersey. At the clair State College. She served on the board of directors of the beginning of their careers both Whitehead Institute for Biochemical Research, was chairman of taught high school math and the Educational Foundation and was past director and historian of science. Herman Sokol received an M.S. in chemistry from the the American Association of University Women. Mrs. Sokol was University of Michigan in 1940 and subsequently received a Ph.D. a volunteer at the Metropolitan Museum of Art. She herself was in Organic Chemistry from New York University. an active and enthusiastic art collector and owned an extensive During World War II, Dr. Sokol was involved with the Rub- collection of modern art. ber Reserve Corporation in the government’s synthetic rubber In 1984 Dr. and Mrs. Sokol established the Margaret and Her- program and later, with Heyden-Newport Chemical Corporation, man Sokol Fellowships for the support of graduate students in now a part of Tenneco, Inc. He was one of the pioneers in the the Chemistry Department. At the establishment of this Fellow- American antibiotic production program. After the war, Dr. Sokol ship both Dr. and Mrs. Sokol expressed the desire to meet with was responsible for the design, construction and start-up of the the recipients and to hear about their careers. The first Sokol first antibiotic plant built in Europe under the Marshall Plan. In fellowship was awarded in 1985 when unfortunately Dr. Sokol the early 1950’s, Dr. Sokol and several associates discovered the died. Most of the awardees have met with Mrs. Sokol, either in important antibiotic tetracycline and developed that basic processes New York or in Ann Arbor on her periodic visits to the campus. for its manufacture which are used world-wide. She believed that the help that she and Herman provided for these

20 2006 young scientists carried Dr. Sokol’s contributions into the next 1992, the Margaret and Herman Sokol International Travel grants generation. During the visits several faculty here, particularly were instituted to enable graduate students to work abroad. Professors Ashe, Curtis and Kuczkowski, became friends. Her The Department of Chemistry has very recently been informed of last visit was in 2003 when she was able to meet several junior the Sokol’s bequest to support programs in Chemistry and in LSA. faculty members. The bequest provides two million dollars to endow the Margaret and Over the years, Margaret saw new opportunities to help us. Herman Sokol Chair in Medicinal Chemistry in the Department of In 1990 she established the Sokol Scholar program for eight Chemistry. One and a half million dollars will endow two graduate incoming undergraduate students who indicated an interest in fellowships in Chemistry. An additional two million dollars will be chemistry and show academic promise. In 1991 she established used to establish the Margaret and Herman Sokol Faculty Award the Margaret and Herman Sokol Faculty Award. This award is Fund for grants for research projects of exceptional promise. This presented annually to a member of the faculty in LSA in the De- award is for science departments in LSA. partment of Astronomy, Biology, Chemistry, Geology, Mathemat- This bequest means that Margaret and Herman Sokol’s exceptional ics or Physics. Since that time Chemistry professors Kopelman, generosity will continue to be felt and appreciated by Michigan Morris, Pecoraro and Coucouvanis have received the award. In Chemists!

Jean W. Clappison (BS, 1948) passed away sity) contributing to the extraction of pure cage molecules and carbon nanotubes. Smal- March 6, 2004. metallic uranium, making nuclear reactors ley began his career as a research chemist at Shell Chemical Co where he worked for 4 Bob Cook, the former handyman for the possible. In 1946, he became a research years after graduation from Michigan before department, died October, 11, 2006 at the chemist for Shell Development Company pursuing the PhD. He undertook postdoc- age of 74. He retired in 1994 after working Research Center in Emeryville, CA. After toral study at the University of Chicago at the department for almost 15 years. To retiring in 1971, he continued research with Donald Levy, Lennard Wharton and this date, many of Bob’s creations are still on the interstitial model of the electronic Daniel Auerbach where he helped to develop in active use. structure of metals and alloys with a series of appointments at academic institutions in supersonic nozzle beam techniques applied Don Eden (BS, 1966; PhD 1971, MIT) the U.S. and abroad in China, Japan, Sweden, to laser spectroscopy. This interest eventu- died on Aug 23, 2000. He was professor of and France. As a member of the Federation ally led to the experiment in 1985 involving chemistry and biochemistry at San Fran- of American Scientists, and throughout his the laser ablation of carbon probed by mass cisco State University. The Eden Academic life, he continued to be concerned about the spectrometry that produced C60. In the latter Excellence Award in Chemistry and Phys- unprecedented dangers of nuclear war. decade of his career he became known for ics has been established for upper level Bruce H. Justice his influence on the nanotechnology field. undergraduates. (BS 1955, Dartmouth; PhD 1961, Westrum) died on Feb 22, 2005. He He played a key role in creating the National Walter Kilbourn Duerkson (PhD 1967, was employed by Dow Corning and retired Nanotechnology Initiative and became a Tamres) passed away on Oct. 12, 2005. He from Allied Signal Corp in Buffalo NY in spokesperson on the energy crises. was employed with Y-12 in Oak Ridge as a 1987. Bruce contributed to the development David W. Stewart (BS, 1935; PhD, 1939, research chemist with 38 years of service. of rocket propellants for the U.S. Department Fajans) died May 9, 2004. He investigated Howard Hetzner (BS Illinois; PhD 1939, of Defense as well as a variety of patent and isotope separation as a postdoc with Harold Schoepfle/Gomberg)passed away on Oct.30, proprietary processes used to manufacture Urey at Columbia, and moved to Rochester, 2004, Hetzner worked as a research chemist integrated circuits. After retirement he lived NY when this project was transferred to the for Standard Oil of California at the Rich- in Traverse City where he continued research Kodak Research Labs. He was detached to mond refinery. He served as a petroleum and publishing in the field of calorimetry and the Manhattan Project, in Oak Ridge, from specialist for the Petroleum Administration heat capacity data with Ed Westrum. 1942-44 to work on the magnetic separation during the War from 1942-44 in Washington Gloria D. Manalo (MS 1944; PhD 1945, of U-235. Stewart retired as Senior Labora- D.C. and for the Atomic Energy Program Willard) passed away on June 27, 2006 at tory Head of analytical instrumentation at in Livermore. After appointments with the age of 88. After retiring she worked on Kodak in 1975. He was trustee, president, Standard Oil in Phoenix, AZ and San Fran- a literature survey of studies of Philippine assistant controller and controller of the First cisco, CA, he became Manager of Product plants that was published with coauthor Unitarian Church in Rochester over 30 years. Engineering and retired in 1977. Maureen Genetiano for the National Re- He is survived by his two sons. The David W. search Council of the Philippines. Stewart Memorial Fund has been established Alan Hutchcroft (PhD 1969, Lawton) died in his memory in the department. on Oct 8, 2005. He was Professor Emeritus Richard E. Smalley (BS, 1965; PhD, 1973, of Chemistry, Rockford College, where he Princeton) died on Oct. 25, 2005. Smalley Charles (Chuck) E. Woodard (BS, 1951) had served over 36 years. shared the 1996 Nobel Prize in Chemistry passed away on Oct 31, 2002. Since retir- with Robert Curl and Harold Kroto for ing from Reflexite Corp in 1994, Chuck Oliver Johnson (BS Northern Michigan; volunteered for Habitat for Humanity, AARP PhD 1943, Fajans) passed away on July co-discovering buckministerfullerene com- monly known as buckyball (C ). This led to as a teacher of 55Alive courses and was a 10, 2001. He worked on the Manhattan 60 deacon at his church. Project at Iowa State College (now Univer- the new field of fullerene research on carbon

U-M DEPARTMENT OF CHEMISTRY 21 Gary D. Glick, Werner E. Bachmann Collegiate Kathleen V. Nolta, Lecturer IV. Organic Bio- Faculty Professor of Chemistry; Professor, Biological chemistry. Chemistry. Bioorganic Chemistry, Molecular Vincent L. Pecoraro, John T. Groves Collegiate Hashim M. Al-Hashimi, Assistant Professor Recognition. Professor of Chemistry; Research Scientist, of Chemistry; Assistant Research Scientist, Theodore Goodson, III, Professor of Chemistry; Biophysics Research Division. Synthetic In- Biophysics Research Division. Chemical Professor, Macromolecular Science & Engi- organic and Bioinorganic Chemistry. Biology. neering. Physical Chemistry James E. Penner-Hahn, Professor of Chemis- Ioan Andricioaei, Assistant Professor, Chemistry; Kristina Hakansson, Dow Corning Assistant try; Research Scientist, Biophysics Research Research Assistant Professor, Bioinformatics. Professor. Analytical Chemistry. Division; Associate Dean, LSA. Biophysical Chemical Biology Marc J. A. Johnson, Assistant Professor. Inor- Chemistry and Inorganic Spectroscopy. Arthur J. Ashe III, Professor of Chemistry; Profes- ganic Synthesis A. Ramamoorthy, Associate Professor of Chem- sor, Macromolecular Science and Engineering. Katrin Karbstein, Assistant Professor. Bio- istry; Associate Research Scientist, Biophys- Organometallic Chemistry. chemistry ics Research Division. Structural Studies of Biological Molecules. Mark M. Banaszak Holl, Professor of Chemistry; Robert T. Kennedy, Hobart H. Willard Collegiate Professor, Macromolecular Science & Engi- Professor of Chemistry; Professor, Pharmacol- Melanie Sanford, Assistant Professsor, Organo- neering. Synthetic and Mechanistic Solution, ogy. Analytical Chemistry. metallic Chemistry. Surface, and Solid State Chemistry. Nancy K. Kerner, Lecturer IV. Chemical Educa- Roseanne J. Sension, Associate Professor of John R. Barker, Professor of Atmospheric, Oce- tion, Learning and Instructional Methods. Chemistry; Associate Professor, Physics. anic and Space Sciences; Professor, Chemistry, Physical Chemistry, Ultrafast Laser Spec- Raoul Kopelman, Richard Smalley University Chemical Kinetics, Atmospheric Chemistry. troscopy. Professor of Chemistry; Professor, Biomedical Heather A. Carlson, Associate Professor of Engineering; Professor, Physics. Analytical/ Robert R. Sharp, Professor. Multidimensional Medicinal Chemistry; Professor, Chemistry, Physical/Biophysical Chemistry. and Multiquantum NMR of Paramagnetic Computational Chemistry, Drug Design, Systems. Masato Koreeda Theoretical Biophysics , Professor of Chemistry; Profes- sor, Medicinal Chemistry. Synthesis of Natural David H. Sherman, John G. Searle Professor of Kate S. Carroll, Assistant Professor of Chemistry; Products, Small Molecule-DNA Interaction, Medicinal Chemistry; Professor, Microbiol- Research Assistant Professor, Life Sciences Chemical Carcinogenesis, Glycobiology. ogy and Immunology; Professor, Chemistry; Institute. Bioinorganic and Biochemistry. Research Professor, Life Sciences Institute. Kevin Kubarych, Assistant Professor. Physical Medicinal Chemistry Mary Anne Carroll, Professor of Atmospheric, and Biophysical Chemistry Oceanic and Space Sciences; Professor, Chem- Jadwiga Sipowska, Lecturer IV. General Nicolai Lehnert, Assistant Professor. Bioinorganic istry. Atmospheric Chemistry. Chemistry Chemistry, Physical Inorganic Chemistry Zhan Chen, Associate Professor of Chemistry; Edwin Vedejs, Moses Gomberg Collegiate Profes- David M. Lubman, Professor of Surgery; Profes- Professor, Macromolecular Science & Engi- sor of Chemistry. Organic Chemistry. sor, Chemistry. Biological Mass Spectrometry, neering. Biomaterial and Polymer Surface, Spectroscopy and Instrumentation. Nils G. Walter, Associate Professor of Chemistry; Biocompatibility. Associate Research Scientist, Biophysics Re- Anna K. Mapp, Associate Professor of Chemis- Mary Sue Coleman, UM President and Professor search Division. Chemical Biology. try; Professor, Medicinal Chemistry. Organic of Chemistry Chemistry, Chemical Biology, New Synthetic John P. Wolfe, Assistant Professor. Organometal- Brian P. Coppola, Arthur F. Thurnau Professor of Methods. lic Chemistry. Chemistry; Associate Chair for Undergraduate E. Neil G. Marsh, Associate Professor of Chem- Ronald W. Woodard, Professor and Chair of Chemistry. Organic Chemistry. Science Learn- Medicinal Chemistry; Professor, Chemistry. ing and Instructional Methods. istry; Associate Professor, Biological Chem- istry. Enzymes, Structure, Mechanism and Medicinal Chemistry. Dimitri Coucouvanis, Lawrence S. Bartell Col- Specificity; Protein Engineering and Molecular Edward T. Zellers, Professor of Environmental legiate Professor of Chemistry. Synthesis, Recognition. and Industrial Health; Professor, Chemistry Structures and Reactivities of Metal Clusters Rowena G. Matthews Environmental-Analytical Chemistry. and Supramolecules. , G. Robert Greenberg University Professor of Biological Chemis- Erik R. P. Zuiderweg, Research Scientist, Bio- James K. Coward, Professor of Medicinal try; Senior Research Scientist, Life Sciences physics Research Division; Professor, Biologi- Chemistry; Professor, Chemistry. Bioorganic Institute; Professor, Chemistry. Biological cal Chemistry; Professor, Chemistry. NMR Chemistry and Medicinal Chemistry. Chemistry. Studies of Biomacromolecular Conformation Barry Dunietz, Assistant Professor. Theoretical Adam J. Matzger, Associate Professor of Chem- and Dynamics in Solution. and Computational Chemistry istry; Associate Professor, Macromolecular Carol A. Fierke, Chair. Jerome and Isabella Karle Science & Engineering. Organic, Polymers/ Professors Emeriti and Emerita: Lawrence S. Collegiate Professor of Chemistry; Professor, Organic Materials. Bartell, S.M. Blinder, M. David Curtis, Thomas Biological Chemistry. Biological Chemistry. Mark E. Meyerhoff, Philip J. Elving Collegiate M. Dunn, Seyhan N. Ege, B.J. Evans, Adon A. Anthony H. Francis, Arthur F. Thurnau Professor Professor. Bioanalytical Chemistry, Electro- Gordus, Henry C. Griffin, Robert L. Kucz- of Chemistry; Associate Dean, LS&A. Mag- chemical and Optical Sensors. kowski, Richard G. Lawton, Lawrence L. Lohr, netic Resonance, Vibrational and Electronic John Montgomery, Professor. Organic and Daniel T. Longone, Joseph P. Marino, Christer Spectroscopy of Materials. Organometallic Chemistry E. Nordman, Paul G. Rasmussen, Peter A.S. Smith, Leroy B. Townsend, Edgar F. Westrum, Eitan Geva, Associate Professor. Theoretical and Michael D. Morris, Professor. Analytical Laser Jr., John R. Wiseman Computational Chemistry. Spectroscopy and Imaging; Electrophoretic John L. Gland, Professor of Chemistry. Solid State Separations. and Surface Chemistry, Physical Chemistry.

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