HHHHHHHHIIII USOO5290775A United States Patent (19) 11) Patent Number: 5,290,775 Sawyer Et Al
HHHHHHHHIIII USOO5290775A United States Patent (19) 11) Patent Number: 5,290,775 Sawyer et al. (45) Date of Patent: Mar. 1, 1994 (54) EUTHANASIA COMPOSITIONS Tona et al., European Journal of Pharmacology, 178, 293-301 (1990). 75) Inventors: Donald C. Sawyer, Okemos; Marlee Dialog Acc. No.: 01999557, American Hospital For A. Langham, DeWitt; Theodore M. mula Y Service; Monograph Title: Quinacrine Hydro Brody, East Lansing, all of Mich. chloride, 1991. 73 Assignee: Board of Trustees operating Michigan Mudge, Goodman and Gilman eds., pp. 866-874, 1985. State University, East Lansing, Mich. CA 106(7):43892s, Nath et al., 1986. CA 103(21):171845d, Dallaire et al., 1985. (21) Appl. No.: 709,193 Don Michael et al., Am. Heart J., 79(6), 1970, pp. 831-842. (22) Filed: Jun. 3, 1991 Mudge, G. H. and Weiner, I.M., Water, Salts and Ions. In Goodman and Gilman's The Pharmacological Basis Related U.S. Application Data of Therapeutics, Gilman, Rall, Nies and Taylor, Ed., 63) Continuation-in-part of Ser. No. 631,090, Dec. 19, New York, p. 846, Pergamon Press, Inc. (1990). 1990. Primary Examiner-Frederick E. Waddell 51) Int. Cl. ..................... A61K 31/54; A61K 31/44; Assistant Examiner-Kimberly R. Jordan A61K 31/47; A61K 31/16 Attorney, Agent, or Firm-Ian C. McLeod 52) U.S. C. ................................. 514/224.8; 514/289; 57 ABSTRACT 514/296; 514/313; 514/626; 514/629; 514/630 An euthanasia solution based upon gamma-hydroxybu 58) Field of Search ..................... 514/224.8, 289, 296, tramide, a cardiotoxic amount of a compound selected 514/313, 626, 629, 630 from a chloroquine and quinacrine compound and lido (56) References Cited caine as a base or as a water soluble salt is described.
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