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Clinical Evidence on Visceral Pain. Systematic Review Evidência Clínica Sobre Dor Visceral

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Clinical Evidence on Visceral Pain. Systematic Review Evidência Clínica Sobre Dor Visceral Rev Dor. São Paulo, 2017 jan-mar;18(1):65-71 REVIEW ARTICLE Clinical evidence on visceral pain. Systematic review Evidência clínica sobre dor visceral. Revisão sistemática Durval Campos Kraychete1, José Tadeu Tesseroli de Siqueira2, João Batista Garcia3, Rioko Kimiko Sakata4, Ângela Maria Sousa5, Daniel Ciampi de Andrade6, Telma Regina Mariotto Zakka7, Manoel Jacobsen Teixeira7 and Diretoria da Sociedade Brasileira para o Estudo da Dor de 2015 DOI 10.5935/1806-0013.20170014 ABSTRACT RESUMO BACKGROUND AND OBJECTIVES: Visceral pain is in- JUSTIFICATIVA E OBJETIVOS: A dor visceral é causada por duced by abnormalities of organs such as stomach, kidneys, anormalidades de órgãos como o estômago, rim, bexiga, vesícula bladder, gallbladder, intestines and others and includes disten- biliar, intestinos ou outros e inclui distensão, isquemia, inflama- sion, ischemia, inflammation and mesenteric traction. It is re- ção e tração do mesentério. É responsável por incapacidade física sponsible for physical and psychic incapacity, absenteeism and e psíquica, absenteísmo do trabalho e má qualidade de vida. O poor quality of life. This study aimed at discussing major aspects objetivo deste estudo foi discutir os principais aspectos da dor of visceral pain with regard to prevalence, etiology and diagnosis. visceral relacionados a prevalência, etiologia e diagnóstico. CONTENTS: According to Evidence-Based Medicine concepts, CONTEÚDO: Foram revisados segundo os preceitos da Medic- visceral pain etiology, diagnosis and prognosis were reviewed in ina Baseada em Evidência os enfoques etiológicos, diagnóstico LILACS, EMBASE and Pubmed databases. Therapeutic stud- e prognóstico da dor visceral nas bases de indexações biomédi- ies were not selected. The following terms were used as search cas, LILACS, EMBASE e Pubmed. Não foram selecionados os strategy: (“visceral pain”[MeSH Terms] OR (“visceral”[All estudos terapêuticos. Utilizou-se como estratégia de busca os Fields] AND “pain”[All Fields]) OR “visceral pain”[All Fields]). termos: («visceral pain»[MeSH Terms] OR (“visceral”[All Fields] Only studies published in Portuguese, English or Spanish were AND “pain”[All Fields]) OR “visceral pain”[All Fields]). Somente included. Narrative reviews with opinionated content and spe- foram incluídos os estudos publicados em português, inglês ou cific therapeutic procedures of medical specialties were excluded. espanhol. Foram excluídas as revisões narrativas de conteúdo Studies on visceral pain related to heart, cancer and musculoskel- opinativo e procedimentos terapêuticos específicos das especiali- etal diseases and pregnancy were also excluded. dades médicas. Também foram excluídos os estudos sobre dor CONCLUSION: Visceral pain is a heterogeneous condition visceral relacionada às doenças do coração, neoplásicas, muscu- where most frequent presentation is abdominal pain in the course loesqueléticas e a gestação. of irritable bowel syndrome. Other diseases induce visceral pain CONCLUSÃO: A dor visceral é uma condição heterogênea, and adequate diagnosis is critical for effective treatment. cuja apresentação mais frequente é de dor abdominal no curso Keywords: Chronic pain, Systematic review, Visceral pain. de síndrome do intestino irritável. Outras doenças cursam com dor visceral e o diagnóstico adequado é fundamental para o trata- mento eficaz. Descritores: Dor crônica, Dor visceral, Revisão sistemática. INTRODUCTION The International Association for the Study of Pain (IASP) has updated in 2011 visceral pain taxonomy and identifica- 1. Universidade Federal da Bahia, Salvador, BA, Brasil. 2. Universidade de São Paulo, São Paulo, SP, Brasil. tion among chronic conditions, according to anatomic loca- 3. Universidade Federal do Maranhão, SP, Brasil. tion in abdominal viscerae, chest and neck1. 4. Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil. 5. Instituto do Câncer Octavio Frias de Oliveira, São Paulo, SP, Brasil. Visceral pain is characterized by painful subjective percep- 6. Universidade de São Paulo, Faculdade de Medicina, São Paulo, SP, Brasil. tion in the abdomen or chest, and may be referred to so- 7. Universidade de São Paulo, Hospital das Clínicas, São Paulo, SP, Brasil. matic structures. So, it is difficult to diagnose visceral pain, Submitted in December 01, 2015. especially if it is long-lasting, recurrent and without specific Accepted for publication in February 03, 2017. pathophysiological abnormality. Conflict of interests: none – Sponsoring sources: Cognos - Educação em Saúde - www. cognos.med.br and Brazilian Society for the Study of Pain. Functional chronic visceral pain is one of the most common causes of morbidity among general population. Functional Correspondence to: Rua Rio de São Pedro, 327 – 403 – Bairro da Graça chronic visceral pain (FCVP) and functional gastrointestinal 40150-350 Salvador, BA, Brasil disorders (FGID) have different definitions: E-mail: [email protected] • FCVP is defined as pain coming from internal organs (vis- © Sociedade Brasileira para o Estudo da Dor ceral) such as stomach, kidneys, gallbladder and others, and 65 Rev Dor. São Paulo, 2017 jan-mar;18(1):65-71 Kraychete DC, Siqueira JT, Garcia JB, Sakata RK, Sousa AM, Andrade DC, Zakka TR, Teixeira MJ and Diretoria da Sociedade Brasileira para o Estudo da Dor de 2015 lasting more than three months. The term functional de- myelotomy, botulinum toxin injection, acupuncture, homeopa- scribes a symptom or complex of symptoms in the absence of thy and alternative practices. Studies on visceral pain related to any structural or tissue abnormality. heart, cancer, musculoskeletal diseases and gestation were also • FGID is defined as digestive system disorder where symptoms excluded. cannot be explained by the presence of structural or tissue chang- The following strategy was adopted for complementary Pubmed es, based on clinical symptoms. query: (“visceral pain”[MeSH Terms] OR (“visceral”[All Fields] Visceral pain causes depend on the nature of triggering stimu- AND “pain”[All Fields]) OR “visceral pain”[All Fields]) AND lation. Symptoms characteristics are: 1) abrupt onset; 2) wide- (“2013/01/01”[PDAT]: “2015/11/30”[PDAT]). Scientific qual- spread and difficult to locate pain, more often perceived along ity of publications was evaluated as A (high), B (moderate), C trunk midline; 3) pain referred on superficial tissues; 4) presence (low) and D (very low), by the GRADE system4. of hyperalgesia; 5) motor, autonomic and affective responses ac- Words visceral, somatic, neuropathic and psychogenic were tivation2. considered to evaluate the proportion of studies on pain. We Other authors have added more characteristics: 1) it is not ended up with 16337 quotations until 2013. After adding the evoked by all viscerae (solid organs such as liver, kidneys, pul- filter corresponding to most recent studies from 1/1/2013 to monary parenchyma are not sensitive to pain); 2) it is not always 11/30/2015, we have obtained 4461 quotations, being visceral associated to visceral injury. A low threshold stimulus may acti- pain the second most studied from the four types of pain. Figure vate visceral sensory afferents, such as intraluminal gas pressure; 1 shows increased number of recent publications as compared to 3) it is referred in other sites, probably related to visceral and somatic and psychogenic pain, although neuropathic pain was somatic nervous fibers convergence when connecting in spinal the one with the highest growth rate in number of quotations, cord dorsal horn3. probably due to the interest of pharmaceutical industries. Based on the importance of the subject, the Brazilian Society for the Study of Pain (SBED), in 2013, which has been the inter- 70.0% national year against visceral pain, tried to gather best scientific 65.3% quality material to sensitize healthcare system researchers, clini- 60.0% cians and managers for the impact and consequences of lack of 50.0% 46.8% adequate diagnosis and management of this syndrome. This document updates systematic reviews of Pubmed, EM- 40.0% BASE and LILACS databases on Visceral Pain, carried out by 30.0% SBED in the year 2013. The objective of this study is limited to 23.9% 23.6% 18.6% the publication of articles indexed just as visceral pain. 20.0% 14.8% 10.0% 5.8% CONTENTS 1.3% 0.0% Visceral Somatic Neuropathic Psychogenic According to Evidence-Based Medicine concepts, etiologic and Before After prognostic visceral pain approaches were reviewed in the two Figure 1. Quotations on Pubmed database, according to type of pain, largest biomedical databases, Pubmed and EMBASE, and in LI- before and after January 2013 LACS database for being the one with the highest number of Brazilian publications. Original diagnostic or therapeutic studies on peculiarities of different specialties related to the subject and In the first search, in 2013, 105 scientific articles were selected which moved away from the interest of general informative and from 1793 recovered quotations. From these, 37 quotations were educational aspects were not included. Although not including selected by the group to continue with the process. Evidence original articles on diagnosis and therapy in the primary search synthesis corresponded to the evaluation of 34 full text articles, of this review, a complementary Pubmed search was carried out presented in the literature quotation format in Vancouver style, to recover systematic reviews of diagnostic and therapeutic stud- publication quality evaluated by the GRADE system and text ies on primary
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