Clinical Outcomes at 1 Year Following Transcatheter Aortic Valve Replacement

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Clinical Outcomes at 1 Year Following Transcatheter Aortic Valve Replacement Supplementary Online Content Holmes DR, Brennan JM, Rumsfeld JS, et al; STS/ACC TVT Registry. Clinical outcomes at 1 year following transcatheter aortic valve replacement. JAMA. doi:10.1001/jama.2015.1474 eFigure 1. Study Cohort Development of TAVR Patients From Nov. 2011 to June 2014 eFigure 2. Cumulative Incidence of Outcomes by Society of Thoracic Surgeons Predicted Risk of Mortality eFigure 3. Cumulative Incidence of Outcomes by Age eFigure 4. Cumulative Incidence of Outcomes by Sex eFigure 5. Cumulative Incidence of Outcomes by Renal Failure eFigure 6. Cumulative Incidence of Outcomes by Left Ventricular Ejection Fraction eFigure 7. Cumulative Incidence of Outcomes by Access Site eFigure 8. Cumulative Incidence of Outcomes by Preoperative Atrial Fibrillation/Flutter eFigure 9. Cumulative Incidence of Outcomes by Chronic Obstructive Pulmonary Disease eAppendix 1. STS/ACC TVT Registry Participating Hospitals eAppendix 2. Definitions eAppendix 3. Patient Characteristics for Medicare-Linked Patients Who Were Excluded From the Study Cohort eAppendix 4. In-Hospital Outcomes for Medicare-Linked Patients Who Were Excluded From the Study Cohort This supplementary material has been provided by the authors to give readers additional information about their work. © 2015 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 eFigure 1. Study Cohort Development of TAVR Patients From Nov. 2011 to June 2014 TAVR patients Nov. 2011 – Jun. 2014 65+ years old with Medicare Insurance N=15,792 admissions of 15,658 patients at 304 sites Exclude records not linked to Exclude records from Exclude records whose index Medicare patients without Part A & B admission is not linked to N=442 admissions, 68 sites and Fee-For-Service Medicare inpatient claims N=208 admissions, 118 sites N=2,856 admissions, 267sites Include only the index admission of each patient Exclude N=104 admissions, 299 sites Patient population studied N=12,182 admissions of 12,182 patients at 299 sites In the final study population, 5 sites were excluded from the original 304 sites, because all the patients in those sites could not be linked to Medicare, or did not have Part A&B/Fee-For-Service, or their index admissions could not be linked to Medicare inpatient claims. Downloaded From: https://jamanetwork.com/ on 09/29/2021 © 2015 American Medical Association. All rights reserved. eFigure 2. Cumulative Incidence of Outcomes by Society of Thoracic Surgeons Predicted Risk of Mortality A. Mortality B. Stroke AVRI = Aortic Valve Re-intervention; HF = Heart Failure © 2015 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 eFigure 2. Cumulative Incidence of Heart Failure by Society of Thoracic Surgeons Predicted Risk of Mortality (continued) C. Heart Failure D. AVRI AVRI = Aortic Valve Re-intervention; HF = Heart Failure © 2015 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 eFigure 3. Cumulative Incidence of Outcomes by Age A. Mortality B. Stroke AVRI = Aortic Valve Re-intervention; HF = Heart Failure © 2015 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 eFigure 3. Cumulative Incidence of Outcomes by Age (continued) C. Heart Failure D. Aortic Valve Re-intervention AVRI = Aortic Valve Re-intervention; HF = Heart Failure © 2015 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 eFigure 4. Cumulative Incidence of Outcomes by Sex A. Mortality B. Stroke AVRI = Aortic Valve Re-intervention; HF = Heart Failure © 2015 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 eFigure 4. Cumulative Incidence of Outcomes by Sex (continued) C. Heart Failure D. Aortic Valve Re-intervention AVRI = Aortic Valve Re-intervention; HF = Heart Failure © 2015 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 eFigure 5. Cumulative Incidence of Outcomes by Renal Failure A. Mortality B. Stroke AVRI = Aortic Valve Re-intervention; HF = Heart Failure © 2015 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 eFigure 5. Cumulative Incidence of Outcomes by Renal Failure (continued) C. Heart Failure D. Aortic Valve Re-intervention AVRI = Aortic Valve Re-intervention; HF = Heart Failure © 2015 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 eFigure 6. Cumulative Incidence of Outcomes by Left Ventricular Ejection Fraction A. Mortality B. Stroke AVRI = Aortic Valve Re-intervention; HF = Heart Failure; LVEF = Left Ventricular Ejection Fraction © 2015 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 eFigure 6. Cumulative Incidence of Outcomes by Left Ventricular Ejection Fraction (continued) C. Heart Failure D. Aortic Valve Re-intervention AVRI = Aortic Valve Re-intervention; HF = Heart Failure; LVEF = Left Ventricular Ejection Fraction © 2015 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 eFigure 7. Cumulative Incidence of Outcomes by Access Site A. Mortality B. Stroke AVRI = Aortic Valve Re-intervention; HF = Heart Failure © 2015 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 eFigure 7. Cumulative Incidence of Outcomes by Access Site (continued) C. Heart Failure D. Aortic Valve Re-intervention AVRI = Aortic Valve Re-intervention; HF = Heart Failure © 2015 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 eFigure 8. Cumulative Incidence of Outcomes by Preoperative Atrial Fibrillation/Flutter A. Mortality B. Stroke AVRI = Aortic Valve Re-intervention; HF = Heart Failure © 2015 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 eFigure 8. Cumulative Incidence of Outcomes by Preoperative Atrial Fibrillation/Flutter (continued) C. Heart Failure D. Aortic Valve Re-intervention AVRI = Aortic Valve Re-intervention; HF = Heart Failure © 2015 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 eFigure 9. Cumulative Incidence of Outcomes by Chronic Obstructive Pulmonary Disease A. Mortality B. Stroke COPD categories are defined as follows: None = No documented chronic lung disease; Mild = FEV1 60% to 75% of predicted, and/or on chronic inhaled or oral bronchodilator therapy; Moderate=FEV1 50% to 59% of predicted, and/or on chronic steroid therapy aimed at lung disease; Severe = FEV1 <50% predicted, and/or Room Air pO2 < 60 or Room Air pCO2 > 50. © 2015 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 eFigure 9. Cumulative Incidence of Outcomes by Chronic Obstructive Pulmonary Disease (continued) C. Heart Failure D. Aortic Valve Re-intervention COPD categories are defined as follows: None = No documented chronic lung disease; Mild = FEV1 60% to 75% of predicted, and/or on chronic inhaled or oral bronchodilator therapy; Moderate=FEV1 50% to 59% of predicted, and/or on chronic steroid therapy aimed at lung disease; Severe = FEV1 <50% predicted, and/or Room Air pO2 < 60 or Room Air pCO2 > 50. © 2015 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 eAppendix 1. STS/ACC TVT Registry Participating Hospitals Facility Name City State Huntsville Hospital Huntsville AL Princeton Baptist Medical Center Birmingham AL Springhill Hospital Inc Mobile AL St. Vincent Hospital Birmingham AL University of Alabama Hospital Birmingham AL Arkansas Heart Hospital Little Rock AR CHI St Vincent Infirmary Little Rock AR Banner Good Samaritan Med Ctr Phoenix AZ Banner Heart Hospital Phoenix AZ Mayo Clinic Arizona Phoeniz AZ Saint Joseph's Hospital Phoenix AZ Scottsdale Healthcare Shea Scottsdale AZ Tucson Medical Center Tucson AZ UAMC – University Campus Tucson AZ Yuma Regional Medical Center Yuma AZ Alta Bates Summit Medical Center Oakland CA Cedars-Sinai Health Systems Los Angeles CA El Camino Hospital Mountain View CA Fresno Community Hospital and Medical Center Fresno CA Good Samaritan Hospital Los Angeles CA Harbor UCLA Medical Center Torrance CA Hoag Memorial Hospital Presbyterian Newport Beach CA John Muir Medical Center - Concord Campus Walnut Creek CA Kaiser Permanente Medical Center San Francisco CA Keck Hospital of USC Los Angeles CA Long Beach Memorial Medical Center Long Beach CA Los Robles Hospital & Medical Center Thousand Oaks CA Mercy General Hospital - Sacramento Sacramento CA Saint Agnes Medical Center Fresno CA Saint Bernadine Medical Center San Bernardino CA Scripps Green Hospital La Jolla CA Scripps Memorial Hospital-La Jolla La Jolla CA Sharp Grossmont Hospital La Mesa CA Sharp Memorial Hospital San Diego CA Stanford HEALTH CARE Palo Alto CA Sutter Medical Center - Sacramento Sacramento CA Torrance Memorial Medical Center Torrance CA UC San Diego Health System Sulpizio CV Center La Jolla CA University of California (UCLA) Los Angeles CA University Of California Davis Medical Center Sacramento CA © 2015 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 Facility Name City State Exempla Saint Joseph Hospital Denver CO Medical
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