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V Olume 51 • Issue 2 • a Ugust 2021 Web ofIndexed Science in Original Articles Anti-proliferative effects of indomethacin, acemetacin and their tromethamine salts in HCT116 human colon cancer cells Gökçe Cihan Üstündağ, Berna Somuncu, Meltem Müftüoğlu, Nilgün Karalı In vitro assessment of cytotoxic, apoptotic and genotoxic effects of metformin Tuba Sarıaydın, Tuğbagül Çal, Sevtap Aydın Dilsiz, Hande Canpınar, Ülkü Ündeğer Bucurgat Nickel oxide nanoparticles induced DNA damages in human liver cells Mahmoud Abudayyak, E. Elif Güzel, Gül Özhan Effects of chlorpyrifos-methyl, chlormequat, deltamethrin, glyphosate, pirimiphos-methyl, tebuconazole and their mixture on oxidative stress and toxicity in HUVEC cell line Çiğdem Sevim, Ali Taghizadehghalehjoughi, Mehtap Kara The effects of prochloraz on the levels of nuclear receptor genes expressions and global DNA methylation in human prostate carcinoma cells Ecem Fatma Karaman, Esma Doğan, Dilara Alga, Sibel Özden Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey Mehmet Akyüz, Işık Didem Karagöz, Şule İnci, İbrahim Halil Kılıç, Sevda Kırbağ, Başak Simitçioğlu Central possible antinociceptive mechanism of naringin Mehmet Evren Okur, Çinel Köksal Karayıldırım Anti-fertility and antisteroidogenic activity of Clerodendrum serratum in mature male rats Navaneetha Krishnan Subramaniyan, Nagarajan Govinda Rajan, Karthikeyan Elumalai, Sathyanathan Viswanathan, Jayaraman Rajangam, Preeti Gutha, Sivaneswari Srinivasan Curcumin prevents tenofovir/lamivudine/efavirenz-induced nephrotoxicity in rats Elias Adikwu, Ruth O. Owota, Innocent Biradee Phytochemical profiling of the bioactive principles ofAlysicarpus glumaceus (Vahl) DC. aerial parts Ferhat Khan, Mohammed Garba Magaji, Ibrahim Abdu-Aguye, Isa Marte Hussaini, Asmau Hamza, Amina Busola Olorukooba, Yahaya Muhammad Sani, Muneer Ari Sani, Idris Muhammad Maje Quantitative determinations on commercial samples of Melissae folium and their antioxidant activity Ayşegül Karadeniz, Buket Bozkurt, Gülen İrem Kaya Evaluation of herbal medicine use in the obstetric and gynecology department Yunus Emre Ayhan, Emine Akalın Exploring the effects of individual innovativeness dimensions on performance: a study with pharmaceutical managers Nilay Tarhan, Sevgi Şar Short Paper The preliminary ethnobotanical survey of medicinal plants in Develi (Kayseri/Turkey) Zeynep Büşra Erarslan, Rıdvan Çolak, Şükran Kültür Review Articles VOLUME 51 • ISSUE 2 • AUGUST 2021 51 • ISSUE 2 AUGUST VOLUME Examining the basic principles of quality by design (QbD) approach in analytical studies Burcu Mesut, Cem Önal, Buket Aksu, Yıldız Özsoy The role of compaction simulator equipment in formulation design Yıldız Özalp, Nailla Jiwa Histone deacetylase inhibitors providing an epigenetic treatment in cancer Tuğçe Cinek, Nilgün Karalı ijp.istanbul.edu.tr EISSN 2587-2087 INDEXING AND ABSTRACTING Web of Science - Emerging Sources Citation Index (ESCI) TÜBİTAK-ULAKBİM TR Index CAS Database A-I OWNER Prof. Dr. Erdal CEVHER İstanbul University, Faculty of Pharmacy, Department of Pharmaceutical Technology, İstanbul, Turkey RESPONSIBLE MANAGER Asst. Prof. Bahar GÜRDAL ABAMOR İstanbul University, Faculty of Pharmacy, Department of Pharmaceutical Botany, İstanbul, Turkey CORRESPONDENCE ADDRESS İstanbul University, Faculty of Pharmacy, Department of Pharmaceutical Botany, Beyazıt, 34116, Fatih / İstanbul, Turkey Phone: +90 212 440 02 75 Fax: +90 212 440 02 52 E-mail: [email protected] https://dergipark.org.tr/tr/pub/iujp https://iupress.istanbul.edu.tr/tr/journal/ijp/home PUBLISHER İstanbul University Press İstanbul University Central Campus, 34452 Beyazit, Fatih / İstanbul, Turkey Phone: +90 212 440 00 00 Authors bear responsibility for the content of their published articles. The publication languages of the journal is English. This is a scholarly, international, peer-reviewed and open-access journal published triannually in April, August and December. Publication Type: Periodical A-II EDITORIAL MANAGEMENT BOARD Editor-in-Chief Prof. Dr. Emine AKALIN İstanbul University, Faculty of Pharmacy, Department of Pharmaceutical Botany, İstanbul, Turkey – [email protected] Co-Editors-in-Chief Prof. Dr. B. Sönmez UYDEŞ DOĞAN İstanbul University, Faculty of Pharmacy, Department of Pharmacology, İstanbul, Turkey – [email protected] Prof. Dr. Nilgün KARALI İstanbul University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, İstanbul, Turkey – [email protected] Section Editors Prof. Dr. Nuriye AKEV İstanbul University, Faculty of Pharmacy, Department of Biochemistry, İstanbul, Turkey – [email protected] Prof. Dr. Nilgün KARALI İstanbul University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, İstanbul, Turkey – [email protected] Prof. Dr. B. Sönmez UYDEŞ DOĞAN İstanbul University, Faculty of Pharmacy, Department of Pharmacology, İstanbul, Turkey – [email protected] Prof. Dr. Sevgi GÜNGÖR İstanbul University, Faculty of Pharmacy, Department of Pharmaceutical Technology, İstanbul, Turkey – [email protected] Asst. Prof. Bahar GÜRDAL ABAMOR İstanbul University, Faculty of Pharmacy, Department of Pharmaceutical Botany, İstanbul, Turkey – [email protected] Language Editors Elizabeth Mary EARL Istanbul University, Department of Foreign Languages, Istanbul, Turkey – [email protected] Alan James NEWSON Istanbul University, Department of Foreign Languages, Istanbul, Turkey – [email protected] Statistics Editor Prof. Dr. Abdülbari BENER İstanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Biostatistics and Medical Informatics, İstanbul, Turkey – [email protected] Scientific Secretariat Asst. Prof. Gülsev ÖZEN İstanbul University Faculty of Pharmacy, Department of Pharmacology, İstanbul, Turkey – [email protected] A-III EDITORIAL BOARD Afife MAT İstanbul University, Faculty of Pharmacy, Department of Pharmacognosy, İstanbul, Turkey – [email protected] Berna ÖZBEK-ÇELİK İstanbul University, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, İstanbul, Turkey – [email protected] Bilge ŞENER Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara, Turkey – [email protected] Carsten EHRHARDT Trinity College Dublin, School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute, Dublin, Ireland – [email protected] Claudiu T. SUPURAN University of Florence, Section of Pharmaceutical and Nutriceutical Sciences, Neurofarba Department, Florence, Italy – [email protected] Domenico Vittorio DELFINO University of Perugia, Department of Medicine and Surgery, Perugia, Italy – [email protected] Erden BANOĞLU Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, Turkey – [email protected] Fatma AKAR Gazi University, Faculty of Pharmacy, Department of Pharmacology, Ankara, Turkey – [email protected] Gianniantonio DOMINA University of Palermo, Food and Forest Sciences, Department of Agricultural, Palermo, Italy – [email protected] İlkay KÜÇÜKGÜZEL Marmara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, İstanbul, Turkey – [email protected] Johan Van de VOORDE Ghent University, Department of Pharmacology, Gent, Belgium – [email protected] Melih ALTAN Bezmialem University, Faculty of Pharmacy, Department of Pharmacology, İstanbul, Turkey – [email protected] Meral ÖZALP Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Ankara, Turkey – [email protected] Müberra KOŞAR Eastern Mediterranean University, Faculty of Pharmacy, Department of Pharmacognosy, Famagusta, Northern Cyprus – [email protected] Nilüfer YÜKSEL Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Turkey – [email protected] Nurşen BAŞARAN Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey – [email protected] Oya ALPAR Altınbaş University, Faculty of Pharmacy, Department of Pharmaceutical Technology, İstanbul, Turkey and Department of Pharmaceutical Technology, UCL, UK – [email protected] Özlem Nazan ERDOĞAN İstanbul University, Faculty of Pharmacy, Department of Pharmacy Management, İstanbul, Turkey – [email protected] Sıdıka TOKER İstanbul University, Faculty of Pharmacy, Department of Analytical Chemistry, İstanbul, Turkey – [email protected] Sibel ÖZDEN İstanbul University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, İstanbul, Turkey – [email protected] Stephen R. DOWNIE University of Illinois, Department of Plant Biology, Urbana, Illinois, USA – [email protected] Tao CHEN Medical College of Soochow University, School of Public Health, Department of Toxicology, Suzhou, China – [email protected] Ufuk KOLAK İstanbul University, Faculty of Pharmacy, Department of Analytical Chemistry, İstanbul, Turkey – [email protected] Zeliha YAZICI Biruni University, Faculty of Medicine, Department of Medical Pharmacology, İstanbul, Turkey – [email protected] A-IV INSTRUCTIONS TO AUTHORS AIMS AND SCOPE İstanbul Journal of Pharmacy is currently indexed in Web of Science-Emerging Sources Citation Index, TU- İstanbul Journal of Pharmacy (Istanbul J Pharm) is an BITAK ULAKBIM TR Index and CAS database. international, scientific, open access periodical pub- lished in accordance with independent, unbiased, and Processing and publication
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