Resiniferatoxin CSPR GHS Format 2014

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Chemical Safety Practices Recommendations Resiniferatoxin (Reciniferatoxin, RTX) Exposure Hazards(1) Irritates Skin Affects Nervous System Response to Exposure Oral Dermal Inhalation Injection Rinse mouth; do not Wash skin with soap Leave area; go to clean Report to OHS. induce vomiting. and water for 15 air. Report to OHS. minutes. Rinse eyes Report to OHS if for 15 minutes. difficulty breathing Report to OHS if occurs. irritation develops. Special RTX in DMSO will rapidly penetrate gloves and skin. Precautions Discard garments as hazardous if contaminated with RTX. Personal Gloves (Latex or Nitrile) Protective Skin Protection (Suit, Scrubs or Lab Coat) Equipment Eye Protection (Safety-glasses or Goggles) Closed-toe shoes Engineering RTX powder- Chemical Fume Hood (CFH). Controls RTX solution- CFH or Class II Biosafety Cabinet (B2 if aerosolized) Use full face N100 respirator if engineering controls are not available. Animal Handling No special requirements. Bedding Disposal No special requirements. Work Practices Empty RTX containers and unused RTX must be disposed of as hazardous. Follow LASP SOPs for preparation, handling, dosing, and disposal of RTX. 1. <Resiniferatoxin MSDS Tocris.pdf> [Internet]. 2011 [cited 10/9/2014]. Available from: http://www.tocris.com/literature/1137_sds.pdf?1414155468. 2. Fattorusso E, Lanzotti V, Taglialatela-Scafati O, Tron Gian C, Appendino G. Bisnorsesquiterpenoids from Euphorbia resinifera Berg. and an Expeditious Procedure to Obtain Resiniferatoxin from Its Fresh Latex. Eur J Org Chem. 2002;2002(1):71-8. 3. Kissin I, Szallasi A. Therapeutic targeting of TRPV1 by resiniferatoxin, from preclinical studies to clinical trials. Current topics in medicinal chemistry. 2011;11(17):2159-70. Resiniferatoxin is a natural extract of Resin Spurge (Euphorbia resinifera and Euphorbia Poisonii).(2) It is analogous to capsaicin, binding the the TRPV1 receptor, but with x1000 activity. It is used to induce inflammation or to desensitize pain neurons.(3) . Questions or concerns: Please contact EHS, Ted Witte, [email protected] or 301-846-5860 Reviewed 12/22/2014 .

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TRP Mediation
molecules Review Remedia Sternutatoria over the Centuries: TRP Mediation Lujain Aloum 1 , Eman Alefishat 1,2,3 , Janah Shaya 4 and Georg A. Petroianu 1,* 1 Department of Pharmacology, College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates; [email protected] (L.A.); Eman.alefi[email protected] (E.A.) 2 Center for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates 3 Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The University of Jordan, Amman 11941, Jordan 4 Pre-Medicine Bridge Program, College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates; [email protected] * Correspondence: [email protected]; Tel.: +971-50-413-4525 Abstract: Sneezing (sternutatio) is a poorly understood polysynaptic physiologic reflex phenomenon. Sneezing has exerted a strange fascination on humans throughout history, and induced sneezing was widely used by physicians for therapeutic purposes, on the assumption that sneezing eliminates noxious factors from the body, mainly from the head. The present contribution examines the various mixtures used for inducing sneezes (remedia sternutatoria) over the centuries. The majority of the constituents of the sneeze-inducing remedies are modulators of transient receptor potential (TRP) channels. The TRP channel superfamily consists of large heterogeneous groups of channels that play numerous physiological roles such as thermosensation, chemosensation, osmosensation and mechanosensation. Sneezing is associated with the activation of the wasabi receptor, (TRPA1), typical ligand is allyl isothiocyanate and the hot chili pepper receptor, (TRPV1), typical agonist is capsaicin, in the vagal sensory nerve terminals, activated by noxious stimulants.
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