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TRP Mediation
molecules Review Remedia Sternutatoria over the Centuries: TRP Mediation Lujain Aloum 1 , Eman Alefishat 1,2,3 , Janah Shaya 4 and Georg A. Petroianu 1,* 1 Department of Pharmacology, College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates; [email protected] (L.A.); Eman.alefi[email protected] (E.A.) 2 Center for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates 3 Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The University of Jordan, Amman 11941, Jordan 4 Pre-Medicine Bridge Program, College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates; [email protected] * Correspondence: [email protected]; Tel.: +971-50-413-4525 Abstract: Sneezing (sternutatio) is a poorly understood polysynaptic physiologic reflex phenomenon. Sneezing has exerted a strange fascination on humans throughout history, and induced sneezing was widely used by physicians for therapeutic purposes, on the assumption that sneezing eliminates noxious factors from the body, mainly from the head. The present contribution examines the various mixtures used for inducing sneezes (remedia sternutatoria) over the centuries. The majority of the constituents of the sneeze-inducing remedies are modulators of transient receptor potential (TRP) channels. The TRP channel superfamily consists of large heterogeneous groups of channels that play numerous physiological roles such as thermosensation, chemosensation, osmosensation and mechanosensation. Sneezing is associated with the activation of the wasabi receptor, (TRPA1), typical ligand is allyl isothiocyanate and the hot chili pepper receptor, (TRPV1), typical agonist is capsaicin, in the vagal sensory nerve terminals, activated by noxious stimulants. -
Euphorbia Subg
ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ НАУКИ БОТАНИЧЕСКИЙ ИНСТИТУТ ИМ. В.Л. КОМАРОВА РОССИЙСКОЙ АКАДЕМИИ НАУК На правах рукописи Гельтман Дмитрий Викторович ПОДРОД ESULA РОДА EUPHORBIA (EUPHORBIACEAE): СИСТЕМА, ФИЛОГЕНИЯ, ГЕОГРАФИЧЕСКИЙ АНАЛИЗ 03.02.01 — ботаника ДИССЕРТАЦИЯ на соискание ученой степени доктора биологических наук САНКТ-ПЕТЕРБУРГ 2015 2 Оглавление Введение ......................................................................................................................................... 3 Глава 1. Род Euphorbia и основные проблемы его систематики ......................................... 9 1.1. Общая характеристика и систематическое положение .......................................... 9 1.2. Краткая история таксономического изучения и формирования системы рода ... 10 1.3. Основные проблемы систематики рода Euphorbia и его подрода Esula на рубеже XX–XXI вв. и пути их решения ..................................................................................... 15 Глава 2. Материал и методы исследования ........................................................................... 17 Глава 3. Построение системы подрода Esula рода Euphorbia на основе молекулярно- филогенетического подхода ...................................................................................................... 24 3.1. Краткая история молекулярно-филогенетического изучения рода Euphorbia и его подрода Esula ......................................................................................................... 24 3.2. Результаты молекулярно-филогенетического -
Repertorium Plantarum Succulentarum LIV (2003) Repertorium Plantarum Succulentarum LIV (2003)
ISSN 0486-4271 IOS Repertorium Plantarum Succulentarum LIV (2003) Repertorium Plantarum Succulentarum LIV (2003) Index nominum novarum plantarum succulentarum anno MMIII editorum nec non bibliographia taxonomica ab U. Eggli et D. C. Zappi compositus. International Organization for Succulent Plant Study Internationale Organisation für Sukkulentenforschung December 2004 ISSN 0486-4271 Conventions used in Repertorium Plantarum Succulentarum — Repertorium Plantarum Succulentarum attempts to list, under separate headings, newly published names of succulent plants and relevant literature on the systematics of these plants, on an annual basis. New names noted after the issue for the relevant year has gone to press are included in later issues. Specialist periodical literature is scanned in full (as available at the libraries at ZSS and Z or received by the compilers). Also included is information supplied to the compilers direct. It is urgently requested that any reprints of papers not published in readily available botanical literature be sent to the compilers. — Validly published names are given in bold face type, accompanied by an indication of the nomenclatu- ral type (name or specimen dependent on rank), followed by the herbarium acronyms of the herbaria where the holotype and possible isotypes are said to be deposited (first acronym for holotype), accord- ing to Index Herbariorum, ed. 8 and supplements as published in Taxon. Invalid, illegitimate, or incor- rect names are given in italic type face. In either case a full bibliographic reference is given. For new combinations, the basionym is also listed. For invalid, illegitimate or incorrect names, the articles of the ICBN which have been contravened are indicated in brackets (note that the numbering of some regularly cited articles has changed in the Tokyo (1994) edition of ICBN). -
PESTICIDAL PLANT LEAFLET Euphorbia Tirucalli
PESTICIDAL PLANT LEAFLET Euphorbia tirucalli ROYAL BOTANIC GARDENS Taxonomy and nomenclature Distribution and habitat Family: Euphorbiaceae E. tirucalli is the most widespread of all the Euphorbia Vernacular/ common names : species. It is native in Angola, Eritrea, Ethiopia, Kenya, (English): Firesticks plants, Naked lady, Pencil tree, Malawi, Mauritius, Rwanda, Senegal, Sudan, Tanzania, Milk bush Uganda, and Zanzibar and can survive in a wide range (Maa): Oloilei of habitats. It can grow in tropical arid areas with low (Kipsigis): Lechuangit rainfall, on poor eroded soils, saline soils and high (Kamba): Ndau altitudes up to 2000 m but cannot survive frost. It grows (Swahili): Mtupa mwitu, Mwasi, Utupa wild, often in abandoned sites of homesteads. In Kenya for instance, it is found in Ruaka on the highway to Thikka and in Jilore forest station in Kilifi, in Baringo, Sigor, Makueni and Kitui. Uses Pesticidal uses - The plant’s latex can be used against aphids, mosquitoes, some bacteria and molluscs. However it is also toxic, due to phorbol based diterpenoids causing severe irritation from contact, emesis and purgation from ingestion. Used as a hunter’s tool in local fishing and arrow poisoning in tropical Africa. Dose-dependant latex toxicity to parasitic nematodes such as Haplolaimus indicus, Helicolylenchus indicus and Tylenchus filiformis in vitro. Medicinal uses - In east Africa, latex used against sexual impotence, warts, epilepsy, toothache, hemorrhoids, snake bites, extraction of ecto-parasites and cough. In Malaysia, a poultice of roots and stems can be applied to nose ulceration, haemorrhoids and swellings. In India, it is a remedy for spleen enlargement, asthma, dropsy, leprosy, biliousness, leucorrhea, dyspepsia, jaundice, colic, tumours and bladder stones. -
Synopsis of Euphorbia (Euphorbiaceae) in the State of São Paulo, Brazil
Phytotaxa 181 (4): 193–215 ISSN 1179-3155 (print edition) www.mapress.com/phytotaxa/ PHYTOTAXA Copyright © 2014 Magnolia Press Article ISSN 1179-3163 (online edition) http://dx.doi.org/10.11646/phytotaxa.181.4.1 Synopsis of Euphorbia (Euphorbiaceae) in the state of São Paulo, Brazil OTÁVIO LUIS MARQUES DA SILVA1,3, INÊS CORDEIRO1 & MARIA BEATRIZ ROSSI CARUZO2 ¹Instituto de Botânica, Secretaria do Meio Ambiente, Cx. Postal 3005, 01061-970, São Paulo, SP, Brazil ²Departamento de Ciências Exatas e da Terra, Universidade Federal de São Paulo, Diadema, SP, Brazil 3Author for correspondence. Email: [email protected] Abstract Euphorbia is the largest genus of Euphorbiaceae and is among the giant genera of Angiosperms. In the state of São Paulo, the genus is represented by 23 species occurring in savannas, high altitude fields, and anthropic areas. This work includes an identification key, photographs, and comments on morphology, habitat, and geographical distribution. We reestablish Euphorbia chrysophylla and recognize Leptopus brasiliensis as a synonym of Euphorbia sciadophila. Six new records for the state of São Paulo are presented: Euphorbia adenoptera, E. bahiensis, E. chrysophylla, E. cordeiroae, E. foliolosa and E. ophthalmica. Eight lectotypes are designated. Key words: Neotropical flora, nomenclatural notes, taxonomy Resumo Euphorbia é o maior gênero de Euphorbiaceae e está entre os maiores de Angiospermas. No Estado de São Paulo, está rep- resentado por 23 espécies ocorrendo no cerrado, campos de altitude e áreas antrópicas. Este trabalho inclui uma chave de identificação, comentários sobre morfologia, habitat e distribuição geográfica. Reestabelecemos Euphorbia chrysophylla e reconhecemos Leptopus brasiliensis como sinônimo de Euphorbia sciadophila. Seis novas ocorrências para o Estado de São Paulo são apresentadas: Euphorbia adenoptera, E. -
Ecological Coassociations Influence Species Responses To
Molecular Ecology (2013) 22, 3345–3361 doi: 10.1111/mec.12318 Ecological coassociations influence species’ responses to past climatic change: an example from a Sonoran Desert bark beetle RYAN C. GARRICK,* JOHN D. NASON,† JUAN F. FERNANDEZ-MANJARRES‡ and RODNEY J. DYER§ *Department of Biology, University of Mississippi, Oxford, MS 38677, USA, †Department of Ecology, Evolution and Organismal Biology, Iowa State University, Ames, IA 50011, USA, ‡Laboratoire d’Ecologie, Systematique et Evolution, UMR CNRS 8079, B^at 360, Universite Paris-Sud 11, 91405, Orsay Cedex, France, §Department of Biology, Virginia Commonwealth University, Richmond, VA 23284, USA Abstract Ecologically interacting species may have phylogeographical histories that are shaped both by features of their abiotic landscape and by biotic constraints imposed by their coassociation. The Baja California peninsula provides an excellent opportunity to exam- ine the influence of abiotic vs. biotic factors on patterns of diversity in plant-insect spe- cies. This is because past climatic and geological changes impacted the genetic structure of plants quite differently to that of codistributed free-living animals (e.g. herpetofauna and small mammals). Thus, ‘plant-like’ patterns should be discernible in host-specific insect herbivores. Here, we investigate the population history of a monophagous bark beetle, Araptus attenuatus, and consider drivers of phylogeographical patterns in the light of previous work on its host plant, Euphorbia lomelii. Using a combination of phylogenetic, coalescent-simulation-based and exploratory analyses of mitochondrial DNA sequences and nuclear genotypic data, we found that the evolutionary history of A. attenuatus exhibits similarities to its host plant that are attributable to both biotic and abiotic processes. -
Euphorbiaceae) XI
On the Active Principles of the Spurge Family (Euphorbiaceae) XI. [1] The Skin Irritant and Tumor Promoting Diterpene Esters of Euphorbia tirucalli L. Originating from South Africa G. Fürstenberger* and E. Hecker Institut für Biochemie, Deutsches Krebsforschungszentrum, D-6900 Heidelberg, Bundesrepublik Deutschland Z. Naturforsch. 40c, 631—646 (1985); received April 19, 1985 Skin Irritation, 4-Deoxyphorbol, Cocarcinogenesis, Tumor Promoters, Occupational Cancer The irritant and tumor-promoting constituents of latex of Euphorbia tirucalli L. originating from South Africa were isolated. They were identified as irritant ingenane and tigliane type diterpene esters derived from unsaturated aliphatic acids and acetic acid and the polyfunctional diterpene parent alcohols 4-deoxyphorbol, phorbol and ingenol, respectively. The irritant and tumor-promoting esters of 4-deoxyphorbol are predominant and were fully characterized chemically and biologically. They are positionally isomeric 12,13-acylates, acetates e.g. Euphorbiafactors Ti,—Ti4. As acyl groups they carry homologous, highly unsaturated alipha tic acids of the general structure CH3 — (CH2)m — (CH = CH)„ — COOH (m = 2,4; « = 1,2, 3,4,5; N = 2n + m + 2). Corresponding diesters of 4-deoxy-4a-phorbol are also present which are biologi cally inactive. Comparison of structures and biological activities of 12,13-diesters of 4-deoxyphor- bol indicates that — for a distinct total number of C-atoms (N) in the acyl moiety — an increasing number of conjugated double bonds (n) may increase the irritant but decrease the tumor-promot ing activity. Replacement of the hydroxyl function at C-4 (phorbol-12,13-diesters) by hydrogen (corresponding 4-deoxyphorbol-12,13-diesters) does not essentially alter biological activities. -
102 the Effects of Intravesical
102 Harper M, Brady C. M, Scaravilli F, Fowler C. J. Institute of Neurology, London THE EFFECTS OF INTRAVESICAL RESINIFERATOXIN ON SUBUROTHELIAL NERVE DENSITY IN PATIENTS WITH NEUROGENIC DETRUSOR OVERACTIVITY Aims of Study Somatic and autonomic neural pathways integrated in the CNS regulate urine storage and voiding. When spinal cord lesions disrupt these pathways, an aberrant segmental sacral reflex emerges, the afferent limb of which is comprised of small unmyelinated C-fibres that originate in the suburothelium. This pathological reflex is thought to be the underlying cause of “spinal” neurogenic detrusor overactivity (NDO). We are currently evaluating the role of resiniferatoxin (RTX) in the treatment of refractory “spinal” NDO. RTX is an ultra-potent capsaicin analogue purified from the dried latex of the succulent plant Euphorbia Resinifera. The vanillyl group of RTX facilitates the action of the vanilloid receptor (VR-1), a non-selective cation channel expressed on suburothelial C-fibres. Intravesical therapy with a single dose of RTX results in early acute excitatory effects (“sensitisation”) followed by inhibition of neuropeptide release and neuronal terminal field degeneration (“desensitisation”) (Avelino et al., 2001). In patients with refractory NDO, it has been shown that intravesical therapy with vanilloid compounds such as RTX or capsaicin significantly decreases lower urinary tract symptoms for a period of weeks or months, depending on factors such as dose and disease progression. It is thought that the eventual recurrence of symptoms is related to C-fibre regeneration. We have previously shown that the mean suburothelial nerve density decreases in patients who respond to capsaicin. Our experimental aim is to measure suburothelial nerve density in flexible cystoscopic biopsies in controls and patients with NDO before and after intravesical RTX or placebo. -
Fort Ord Natural Reserve Plant List
UCSC Fort Ord Natural Reserve Plants Below is the most recently updated plant list for UCSC Fort Ord Natural Reserve. * non-native taxon ? presence in question Listed Species Information: CNPS Listed - as designated by the California Rare Plant Ranks (formerly known as CNPS Lists). More information at http://www.cnps.org/cnps/rareplants/ranking.php Cal IPC Listed - an inventory that categorizes exotic and invasive plants as High, Moderate, or Limited, reflecting the level of each species' negative ecological impact in California. More information at http://www.cal-ipc.org More information about Federal and State threatened and endangered species listings can be found at https://www.fws.gov/endangered/ (US) and http://www.dfg.ca.gov/wildlife/nongame/ t_e_spp/ (CA). FAMILY NAME SCIENTIFIC NAME COMMON NAME LISTED Ferns AZOLLACEAE - Mosquito Fern American water fern, mosquito fern, Family Azolla filiculoides ? Mosquito fern, Pacific mosquitofern DENNSTAEDTIACEAE - Bracken Hairy brackenfern, Western bracken Family Pteridium aquilinum var. pubescens fern DRYOPTERIDACEAE - Shield or California wood fern, Coastal wood wood fern family Dryopteris arguta fern, Shield fern Common horsetail rush, Common horsetail, field horsetail, Field EQUISETACEAE - Horsetail Family Equisetum arvense horsetail Equisetum telmateia ssp. braunii Giant horse tail, Giant horsetail Pentagramma triangularis ssp. PTERIDACEAE - Brake Family triangularis Gold back fern Gymnosperms CUPRESSACEAE - Cypress Family Hesperocyparis macrocarpa Monterey cypress CNPS - 1B.2, Cal IPC -
Structural Anatomical Aspects of Two Euphorbia (Euphorbiaceae Juss.) Species Leaves
Anallelle Uniiversiităţiiii diin Craiiova, seriia Agriiculltură – Montanollogiie – Cadastru (Annalls of the Uniiversiity of Craiiova - Agriicullture, Montanollogy, Cadastre Seriies) Voll. XLIX/2019 STRUCTURAL ANATOMICAL ASPECTS OF TWO EUPHORBIA (EUPHORBIACEAE JUSS.) SPECIES LEAVES DAN RĂZVAN POPOVICIU, RODICA BERCU Faculty of Natural and Agricultural Sciences,”Ovidius” University, Constantza University Alley, No. 1, B, 900470, Constantza E-mail: [email protected] Abstract. The paper presents a study concerning the leaf structure (petiole, as the case) and blade of two Euphorbia species belonging to Euphorbiaceae family: Euphorbia trigona Mill., and E. tirucallli L. In literature is little information concerning the leaf petiole or blade anatomy of species of Euphorbia genus in general and concerning these two species in particular. The petiole of Euphorbia trigona possesses one epidermis cells which are more or less rounded in shape, covered by a thin cuticle. The vascular system of the petiole is represented by three closed–collateral vascular bundles. Anatomically, the leaves blade of the studied species are heterogenous and amphistomatic with lacticifers especially presented to the midrib zone, more abundant în Euphorbia tirucalli. The midrib vascular system is more developed in Euphorbia tirucalli than E. trigona. Keywords: anatomy, leaf, mesophyll, laticifers, Euphorbia INTRODUCTION a bushy harvested port, with the The studied species belong to appearance of green rods and thick Euphorbiaceae family, one of the branches as a pencil (hence the largest in the plant world, sometimes popular name of the plant). Leaves are known as spurges. It includes around rare and small (Fig. 1, A). It develops 300 genera and 7,700 species, mainly well in hydroculture’s (Burger and Huft, non-succulent herbs, shrubs and trees 1995). -
Dry Forest Trees of Madagascar
The Red List of Dry Forest Trees of Madagascar Emily Beech, Malin Rivers, Sylvie Andriambololonera, Faranirina Lantoarisoa, Helene Ralimanana, Solofo Rakotoarisoa, Aro Vonjy Ramarosandratana, Megan Barstow, Katharine Davies, Ryan Hills, Kate Marfleet & Vololoniaina Jeannoda Published by Botanic Gardens Conservation International Descanso House, 199 Kew Road, Richmond, Surrey, TW9 3BW, UK. © 2020 Botanic Gardens Conservation International ISBN-10: 978-1-905164-75-2 ISBN-13: 978-1-905164-75-2 Reproduction of any part of the publication for educational, conservation and other non-profit purposes is authorized without prior permission from the copyright holder, provided that the source is fully acknowledged. Reproduction for resale or other commercial purposes is prohibited without prior written permission from the copyright holder. Recommended citation: Beech, E., Rivers, M., Andriambololonera, S., Lantoarisoa, F., Ralimanana, H., Rakotoarisoa, S., Ramarosandratana, A.V., Barstow, M., Davies, K., Hills, BOTANIC GARDENS CONSERVATION INTERNATIONAL (BGCI) R., Marfleet, K. and Jeannoda, V. (2020). Red List of is the world’s largest plant conservation network, comprising more than Dry Forest Trees of Madagascar. BGCI. Richmond, UK. 500 botanic gardens in over 100 countries, and provides the secretariat to AUTHORS the IUCN/SSC Global Tree Specialist Group. BGCI was established in 1987 Sylvie Andriambololonera and and is a registered charity with offices in the UK, US, China and Kenya. Faranirina Lantoarisoa: Missouri Botanical Garden Madagascar Program Helene Ralimanana and Solofo Rakotoarisoa: Kew Madagascar Conservation Centre Aro Vonjy Ramarosandratana: University of Antananarivo (Plant Biology and Ecology Department) THE IUCN/SSC GLOBAL TREE SPECIALIST GROUP (GTSG) forms part of the Species Survival Commission’s network of over 7,000 Emily Beech, Megan Barstow, Katharine Davies, Ryan Hills, Kate Marfleet and Malin Rivers: BGCI volunteers working to stop the loss of plants, animals and their habitats. -
Euphorbiaceae)
Polish Botanical Journal 60(2): 147–161, 2015 DOI: 10.1515/pbj-2015-0024 PHYTOGEOGRAPHICAL ANALYSIS OF EUPHORBIA SUBGENUS ESULA (EUPHORBIACEAE) Dmitry V. Geltman Abstract. Euphorbia subg. Esula is one of four major clades within the genus. A geographical analysis of the 466 species in the subgenus is reported here. Every species was assigned to one of 29 geographical elements clustered in ten groups of ele- ments. This geographical analysis showed that the Tethyan group (comprising nine geographical elements) clearly dominates the subgenus and contains 260 species (55.79% of the total number of species). The most numerous geographical elements are Irano-Turanian (105 species) and Mediterranean (85). Other significant groups of elements are Boreal (91 species, 19.54%), East Asian (40 species, 8.58%), Madrean (26 species, 5.58%), Paleotropical (23 species, 4.94%) and South African (16 species, 3.43%). The area of the Tethyan floristic subkingdom is the center of the modern diversity of E. subg. Esula. It is likely that such diversity is the result of intensive speciation that took place during the Eocene–Miocene. Key words: Euphorbia subg. Esula, geographical elements, Irano-Turanian floristic region, Mediterranean floristic region, phytogeographical analysis, Tethyan floristic subkingdom Dmitry V. Geltman, Komarov Botanical Institute of the Russian Academy of Sciences, Prof. Popov Street, 2, St. Petersburg, 197376, Russia; e-mail: [email protected] Introduction genus euphorbia and its taxonomy cantly differ from traditional ones. For subgenus Esula (Riina et al. 2013), 21 sections were ac- The giant genus Euphorbia L. (Euphorbiaceae) re- cepted on the basis of analyses of the combined cently became a subject of detailed phylogenetic and ITS + ndhF dataset (Fig.