Outlook Chemistry Masterclass

OUTLOOK CHEMISTRY MASTERCLASS

17 October 2013 / Vol 502 / Issue No. 7471

OUTLOOK hemistry was the subject of the 63rd Lindau Nobel CONTENTS CHEMISTRY MASTERCLASS Laureate Meeting this summer, and there was no doubting the human chemistry on the tiny German S50 DRUG DISCOVERY Cisland of Lindau. Participants were absorbed by the lectures Structure-led design and engaged in effervescent conversation in the atrium, with Receptor structures are leading the way to interactions catalysed by ancillary events. new drugs Many of the 34 Nobel laureates were making their second, S53 Q&A Produced with support from: Cycles of discovery third or umpteenth visit to the annual gathering, eager to be Gerhard Ertl Cover art: Sarah J. Coleman challenged by the young minds in attendance and inspired A lateral thinker by the beautiful emerald-green waters of Lake Constance S54 Q&A Editorial Dan Shechtman Herb Brody, Michelle that surround Lindau. This year there was a non-scientific The technology starter Grayson, Tony Scully, laureate in their number: José Ramos-Horta, joint recipient Rachel Jones of the 1996 Nobel Peace Prize. Although peace prizewinners S56 Q&A Art & Design have attended the meeting before, this was the first time Robert Grubbs Wes Fernandes, for the former Prime Minister of East Timor. This was also The bond shifter Mohamed Ashour, S57 Q&A Amr Rahma, Alisdair the first visit for Brian Kobilka, one of the newest laureates. Richard R. Ernst Macdonald, Yara Abdel Kobilka gave the opening lecture on G-protein-coupled A man of many dimensions Rahman receptors (GPCRs), which are the target of around a third Production of all pharmaceuticals. His work in determining the first S59 Q&A Karl Smart, Susan GPCR structures should have big implications for future drug Richard Schrock Gray, Ian Pope, development (S50). A sustainable chemist Leonora Dawson- S60 ENERGY Bowling For the 625 young researchers at Lindau, this was a rare chance to rub shoulders with the scientific elite: to learn from, Fuelling the future Sponsorship Biofuels: the way forward? Reya Silao, Yvette Smith debate with and be inspired by their stories. The Nature Video Marketing team set up four debates between laureates and students, one Elena Woodstock, of which — on the topic of biofuels — is continued in this Steven Hurst Outlook (S60). COLLECTION Project Manager Finally, we have Q&As with five of the chemistry Nobel S62 The changing landscape of careers in Christian Manco laureates (beginning on S53). This year the interviews were the chemical industry Keith J. Watson Art Director conducted and written by young researchers. Kelly Buckheit Krause We are pleased to acknowledge the financial support of S65 LifeTrain: towards a European Publisher Mars, Incorporated in producing this Outlook. As always, framework for continuing professional Richard Hughes development in biomedical sciences Magazine Editor Nature retains sole responsibility for all editorial content. Mike Hardman et al. Rosie Mestel S67 Pressure to perform Editor-in-Chief Michelle Grayson Karen Kaplan Philip Campbell Senior Editor, Supplements S69 Ticket to everywhere Peter Fiske

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