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Správa O Činnosti Organizácie SAV Za Rok 2013

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Správa O Činnosti Organizácie SAV Za Rok 2013 Ústav normálnej a patologickej fyziológie SAV Správa o činnosti organizácie SAV za rok 2013 Bratislava január 2014 Obsah osnovy Správy o činnosti organizácie SAV za rok 2013 1. Základné údaje o organizácii 2. Vedecká činnosť 3. Doktorandské štúdium, iná pedagogická činnosť a budovanie ľudských zdrojov pre vedu a techniku 4. Medzinárodná vedecká spolupráca 5. Vedná politika 6. Spolupráca s VŠ a inými subjektmi v oblasti vedy a techniky 7. Spolupráca s aplikačnou a hospodárskou sférou 8. Aktivity pre Národnú radu SR, vládu SR, ústredné orgány štátnej správy SR a iné organizácie 9. Vedecko-organizačné a popularizačné aktivity 10. Činnosť knižnično-informačného pracoviska 11. Aktivity v orgánoch SAV 12. Hospodárenie organizácie 13. Nadácie a fondy pri organizácii SAV 14. Iné významné činnosti organizácie SAV 15. Vyznamenania, ocenenia a ceny udelené pracovníkom organizácie SAV 16. Poskytovanie informácií v súlade so zákonom o slobodnom prístupe k informáciám 17. Problémy a podnety pre činnosť SAV PRÍLOHY A Zoznam zamestnancov a doktorandov organizácie k 31.12.2013 B Projekty riešené v organizácii C Publikačná činnosť organizácie D Údaje o pedagogickej činnosti organizácie E Medzinárodná mobilita organizácie Správa o činnosti organizácie SAV 1. Základné údaje o organizácii 1.1. Kontaktné údaje Názov: Ústav normálnej a patologickej fyziológie SAV Riaditeľ: RNDr. Oľga Pecháňová, DrSc. Zástupca riaditeľa: MUDr. Fedor Jagla, CSc. Vedecký tajomník: RNDr. Iveta Bernátová, DrSc. Predseda vedeckej rady: RNDr. Iveta Bernátová, DrSc. Členovia snemu SAV: MUDr. Fedor Jagla, CSc., MUDr. Igor Riečanský, PhD. Adresa: Sienkiewiczova 1, 813 71 Bratislava http://www.unpf.sav.sk Tel.: 02/32296063 Fax: E-mail: [email protected] Názvy a adresy detašovaných pracovísk: nie sú Vedúci detašovaných pracovísk: nie sú Typ organizácie: Rozpočtová od roku 1953 1.2. Údaje o zamestnancoch Tabuľka 1a Počet a štruktúra zamestnancov K K do 35 Štruktúra zamestnancov K rokov F P T M Ž M Ž Celkový počet zamestnancov 59 24 35 7 18 58 41,84 23,47 Vedeckí pracovníci 27 15 12 3 7 26 19,88 17,5 Odborní pracovníci VŠ 17 5 12 2 10 17 7,58 5,97 Odborní pracovníci ÚS 12 3 9 2 1 12 11,03 0 Ostatní pracovníci 3 1 2 0 0 3 3,35 0 K – kmeňový stav zamestnancov v pracovnom pomere k 31.12.2013 (uvádzať zamestnancov v pracovnom pomere, vrátane riadnej materskej dovolenky, zamestnancov pôsobiacich v zahraničí, v štátnych funkciách, členov Predsedníctva SAV, zamestnancov pôsobiacich v zastupiteľských zboroch) F – fyzický stav zamestnancov k 31.12.2013 (bez riadnej materskej dovolenky, zamestnancov pôsobiacich v zahraničí v štátnych funkciách, členov Predsedníctva SAV, zamestnancov pôsobiacich v zastupiteľských zboroch) P – celoročný priemerný prepočítaný počet zamestnancov T – celoročný priemerný prepočítaný počet riešiteľov projektov M, Ž – muži, ženy 1 Správa o činnosti organizácie SAV Tabuľka 1b Štruktúra vedeckých pracovníkov (kmeňový stav k 31.12.2013) Rodová Pracovníci s hodnosťou Vedeckí pracovníci v stupňoch skladba DrSc. CSc./PhD. prof. doc. I. IIa. IIb. Muži 1 14 0 3 2 7 6 Ženy 2 10 0 0 2 5 5 Tabuľka 1c Štruktúra pracovníkov podľa veku a rodu, ktorí sú riešiteľmi projektov Veková štruktúra < 31 31-35 36-40 41-45 46-50 51-55 56-60 61-65 > 65 (roky) Muži 1 3 2 1 0 1 0 1 4 Ženy 10 4 0 2 2 1 1 0 0 Tabuľka 1d Priemerný vek zamestnancov organizácie k 31.12.2013 Kmeňoví zamestnanci Vedeckí pracovníci Riešitelia projektov Muži 47,4 49,9 49,7 Ženy 38,8 36,2 35,0 Spolu 42,3 43,8 40,8 1.3. Iné dôležité informácie k základným údajom o organizácii a zmeny za posledné obdobie (v zameraní, v organizačnej štruktúre a pod.) V roku 2013 sa na ÚNPF SAV neuskutočnili zmeny v organizácii a štruktúre. Pokračovalo sa však v renovácii priestorov ústavu. Vzhľadom k uvažovanej transformácii ústavov SAV na VPI, pri reorganizácii jednotlivých laboratórnych jednotiek počítame so vznikom špecializovaného Centra regulácie motoriky a Centra diagnostiky skorých štádií neurodegeneračných porúch, ktorého priestorové budovanie sa začalo adaptáciou bývalých laboratórií zaniknutého Oddelenia kardiovaskulárnej fyziológie človeka. V rámci už existujúceho Centra experimentálnej medicíny v spolupráci s LFUK a Fakultnou nemocnicou počítame so vznikom nového laboratória zameraného na špecifikovanie príčin vzniku niektorých cirkulačných porúch, pre ktoré sme tiež pripravili vhodné priestory. Vybudované boli aj nové priestory pre prácu s bunkovými kultúrami. V spolupráci s TI, plánujeme vznik laboratória pre cielený transport liečiv na báze nanonosičov. 2 Správa o činnosti organizácie SAV 2. Vedecká činnosť 2.1. Domáce projekty Tabuľka 2a Zoznam domácich projektov riešených v roku 2013 Čerpané financie Počet projektov za rok 2013 (v €) ŠTRUKTÚRA PROJEKTOV A A B pre B spolu organi- záciu 1. Vedecké projekty, ktoré boli 9 2 83116 73548 2755 r. 2013 financované VEGA 2. Projekty, ktoré boli r. 2013 2 4 138937 93053 14016 financované APVV 3. Projekty OP ŠF 0 1 - - 246816 4. Projekty centier excelentnosti SAV 1 0 40100 27100 - 5. Iné projekty (FM EHP, ŠPVV, Vedecko-technické projekty, ESF, 3 1 47734 40352 - na objednávku rezortov a pod.) A - organizácia je nositeľom projektu B - organizácia sa zmluvne podieľa na riešení projektu 3 Správa o činnosti organizácie SAV 2.2. Medzinárodné projekty 2.2.1. Medzinárodné projekty riešené v roku 2013 Tabuľka 2b Zoznam medzinárodných projektov riešených v roku 2013 Čerpané financie Počet projektov za rok 2013 (v €) ŠTRUKTÚRA PROJEKTOV A A B pre B spolu organi- záciu 1. Projekty 7. Rámcového programu EÚ 0 0 - - - 2. Multilaterálne projekty v rámci vedeckých programov COST, ERANET, INTAS, EUREKA, 0 2 - - 5815 ESPRIT, PHARE, NATO, UNESCO, CERN, IAEA, ESF (European Science Foundation), ERDF a iné 3. Projekty v rámci medzivládnych dohôd o vedecko-technickej 0 0 - - - spolupráci 4. Bilaterálne projekty 6 1 725 725 - 5. Podpora medzinárodnej spolupráce z národných zdrojov 1 2 22000 22000 6667 (MVTS, APVV,...) 6. Iné projekty financované alebo spolufinancované zo zahraničných 0 0 - - - zdrojov A - organizácia je nositeľom projektu B - organizácia sa zmluvne podieľa na riešení projektu 4 Správa o činnosti organizácie SAV 2.3. Najvýznamnejšie výsledky vedeckej práce 2.3.1. Základný výskum Študovali sme bunkovú a redoxnú signalizáciu v hypertenzii a možnosti modulácie radikálovej homeostázy. Venovali sme sa hlavne možnému využitiu PPAR gama receptora, ktorý zohráva dôležitú úlohu v odpovedi na oxidačný stres. Zistili sme, že podávanie agonistu PPAR gama, pioglitazónu (PIO), signifikantne spomalilo nárast krvného tlaku, zlepšilo lipidový profil ako aj cievnu reláxáciu. PIO u mladých SHR neovplyvnil expresiu a aktivitu NO-syntáz, ale mal tkanivovo špecifický účinok na reguláciu enzýmov SOD, na renín-angiotenzínový systém a komponenty intracelulárnej signalizácie, Akt kinázu a beta-katenín. (Dovinová, Majzúnová, Čacányiová, Kristek, Bališ, Grešová, NSC100-2923-B075B-001-MY3). MAJZÚNOVÁ, Miroslava - DOVINOVÁ, Ima - BARANČÍK, Miroslav - CHAN JULIE, Y.H. Redox signaling in pathophysiology of hypertension. In Journal of Biomedical Science, 2013, vol. 20, p. 69-78. (2.458 - IF2012). DOVINOVÁ, Ima - BARANČÍK, Miroslav - MAJZÚNOVÁ, Miroslava - ZÓRAD, Štefan - GAJDOŠECHOVÁ, Lucia - GREŠOVÁ, Linda - ČAČÁNYIOVÁ, Soňa - KRISTEK, František - BALIŠ, Peter - CHAN JULIE, Y.H. Effects of PPARγ agonist pioglitazone on redox-sensitive cellular signaling in young spontaneously hypertensive rats. In PPAR Research, 2013, vol. 2013, p. 1-11. (2.685 - IF2012). ISSN 1687-4757. 2.3.2. Aplikačný typ Na základe 33 000 údajov z celého Slovenska, vypracovaný návrh referenčných hodnôt krvného tlaku pre populáciu detí a mládeže, s vylúčením vplyvu nadmernej hmotnosti, ktorý zohľadňuje vekovú dynamiku rastu a umožní identifikáciu rizikových hodnôt krvného tlaku v príslušnom veku. V súčasnosti sa analyzuje vplyv zmeny metodiky merania krvného tlaku, zo sfygmomanometrickej (ortuťovým manometrom) na oscilometrickú, na referenčné hodnoty krvného tlaku. Spolupracujeme na budovaní Národného registra SR detí s primárnou hypertenziou a analýze údajov vo vzťahu k rizikovým faktorom, čo prispieva k správnej diagnostike hypertenzie a prehypertenzie u detí, a tiež k lepšej efektivite preventívnych a terapeutických opatrení. (V. Regecová, kumulatívny výsledok grantov VEGA 2/0084/10, APVV–0523-10 a projektu Národný program prevencie ochorení srdca ciev pre deti a dorast). REGECOVÁ, Valéria - BEREŠOVÁ, J. - KELLEROVÁ, Eva. Oscilometrické meranie krvného tlaku u detí - argumenty pre nové štandardy. In Cardiology Letters, 2013, vol. 22, suppl. 2, p. 32S-33S. REGECOVÁ, Valéria - ŠIMURKA, Pavol - KELLEROVÁ, Eva. Štandardizácia merania krvného tlaku v pediatrickej praxi. In Cardiology Letters, 2013, vol. 22, no. 2, p. 199-200. ISSN 1336-2429. 2.3.3. Medzinárodné vedecké projekty Otázka ako mozog tvorí zrakové predstavy je jednou z dôležitých tém pre kognitívnu neurovedu. Na to, aby sme dokázali v mysli manipulovať mentálne obrazy je potrebné ich držať v pracovnej pamäti. Z predchádzajúceho výskumu bolo známe, že tak pri držaní ako aj pri manipulácii zrakových obrazov dochádza k negatívnej výchylke na udalosť viazaných mozgových potenciálov 5 Správa o činnosti organizácie SAV nad zadnou časťou mozgovej kôry. Skúmaním mentálnej rotácie, imaginárneho otáčania objektov, sme zistili, že mozgové potenciály vyvolané manipuláciou v pracovnej pamäti sú nezávislé od potenciálov, ktoré sú vyvolané udržiavaním informácie v pracovnej pamäti. Toto zistenie prispieva k poznaniu mozgových procesov zrakovo-priestorového myslenia. (I. Riečanský, výsledky
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