Critical Neuroscience and Philosophy
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The Eye of the CT Scanner: the Story of Learning to See the Invisible Or
Published online: 2021-03-18 Review The Eye of the CT Scanner: The story of learning to see the invisible or from the fluorescent screen to the photon-counting detector Das Auge des Computertomografen: Die Geschichte vom Sehenlernen des Unsichtbaren oder vom Fluoreszenzschirm zum photonenzählenden Detektor Author Heinz-Peter Schlemmer Affiliation inventiveness, engineering and entrepreneurial spirit created Abt. Radiologie, Deutsches Krebsforschungszentrum, the impressive possibilities of today’s imaging diagnostics. Heidelberg, Germany This contribution accompanies the Roentgen Lecture the author gave on November 13, 2020 in Roentgen’s birth house Key words as part of its inauguration and the closing ceremony of CT, digital radiography, radiations, radiography the 101st Congress of the German Roentgen Society in received 09.10.2020 Remscheid-Lennep. accepted 17.01.2021 Key Points: published online 18.03.2021 ▪ The development of computed tomography was a mile- Bibliography stone in the methodological advancement of imaging Fortschr Röntgenstr 2021; 193: 1034–1048 with X-rays. ▪ DOI 10.1055/a-1308-2693 In the detector pixel invisible X-rays are converted into ISSN 1438-9029 digital electrical impulses, which the computer uses to © 2021. Thieme. All rights reserved. create images. ▪ Georg Thieme Verlag KG, Rüdigerstraße 14, Photon-counting detectors could have significant 70469 Stuttgart, Germany diagnostic advantages for clinical applications. Citation Format Correspondence ▪ Schlemmer H, The Eye of the CT Scanner: The story of Prof. Dr. med. Dipl.-Phys. Heinz-Peter Schlemmer learning to see the invisible or from the fluorescent screen to Abt. Radiologie, Deutsches Krebsforschungszentrum, the photon-counting detector. Fortschr Röntgenstr 2021; Im Neuenheimer Feld 280, 69120 Heidelberg, Germany 193: 1034–1048 Tel.: +49/62 21/42 25 64 Fax: +49/62 21/42 25 67 ZUSAMMENFASSUNG [email protected] Röntgens Fotografien mit der „neuen Art von Strahlen“ lösten ABSTRACT einen weltweiten Begeisterungssturm in allen gesellschaftli- chen Kreisen aus. -
12.2% 116,000 120M Top 1% 154 3,900
We are IntechOpen, the world’s leading publisher of Open Access books Built by scientists, for scientists 3,900 116,000 120M Open access books available International authors and editors Downloads Our authors are among the 154 TOP 1% 12.2% Countries delivered to most cited scientists Contributors from top 500 universities Selection of our books indexed in the Book Citation Index in Web of Science™ Core Collection (BKCI) Interested in publishing with us? Contact [email protected] Numbers displayed above are based on latest data collected. For more information visit www.intechopen.com Chapter Introductory Chapter: Veterinary Anatomy and Physiology Valentina Kubale, Emma Cousins, Clara Bailey, Samir A.A. El-Gendy and Catrin Sian Rutland 1. History of veterinary anatomy and physiology The anatomy of animals has long fascinated people, with mural paintings depicting the superficial anatomy of animals dating back to the Palaeolithic era [1]. However, evidence suggests that the earliest appearance of scientific anatomical study may have been in ancient Babylonia, although the tablets upon which this was recorded have perished and the remains indicate that Babylonian knowledge was in fact relatively limited [2]. As such, with early exploration of anatomy documented in the writing of various papyri, ancient Egyptian civilisation is believed to be the origin of the anatomist [3]. With content dating back to 3000 BCE, the Edwin Smith papyrus demonstrates a recognition of cerebrospinal fluid, meninges and surface anatomy of the brain, whilst the Ebers papyrus describes systemic function of the body including the heart and vas- culature, gynaecology and tumours [4]. The Ebers papyrus dates back to around 1500 bCe; however, it is also thought to be based upon earlier texts. -
Godfrey Hounsfield ”Each New Discovery Brings with It the Seeds of Other, Future Inventions”
HISTORY |ESSR Publications Godfrey Hounsfield ”Each new discovery brings with it the seeds of other, future inventions” By Iwona Sudoł-Szopińska (radiologist) and Marta Panas-Goworska (culture expert) 28 August was the 100th anniversary of the birth of Sir Godfrey Newbold Hounsfield. Godfrey Hounsfield was born on 28 August 1919 in Newark, England. His parents were farmers, and it was at their family farm where the talents of this Nobel Prize laureate showed for the first time. On his own, he mended various machines and even constructed a glider, which he did not forget to mention in his speech at the Nobel Prize gala in 1979: I made hazardous investigations of the principles of flight, launching myself from the tops of haystacks with a home-made glider; I almost blew myself up during exciting experiments using water-filled tar barrels and acetylene to see how high they could be propelled. It would seem that these skills would surely make him an outstanding student and later scientist. This, however, never happened. He was only average at school, and before World War II he enrolled voluntarily on the Royal Air Force (RAF), where he fathomed the arcana of electronics. After the war, owing to the support of his superiors from the army, he was accepted at the Faraday House Electrical Engineering College. This was not, however, a higher school of engineering as we understand it today, but rather a specialist school bridging vocational education with polytechnics that would appear later in the 1960s. This means that genius Godfrey Hounsfield was never formally an engineer and, although he worked in the area of broadly understood information technology, he would speak of his educational shortcomings with these words: You’ve got to use the absolute minimum of mathematics but have a tremendous lot of intuition. -
The Use of Non-Human Primates in Research in Primates Non-Human of Use The
The use of non-human primates in research The use of non-human primates in research A working group report chaired by Sir David Weatherall FRS FMedSci Report sponsored by: Academy of Medical Sciences Medical Research Council The Royal Society Wellcome Trust 10 Carlton House Terrace 20 Park Crescent 6-9 Carlton House Terrace 215 Euston Road London, SW1Y 5AH London, W1B 1AL London, SW1Y 5AG London, NW1 2BE December 2006 December Tel: +44(0)20 7969 5288 Tel: +44(0)20 7636 5422 Tel: +44(0)20 7451 2590 Tel: +44(0)20 7611 8888 Fax: +44(0)20 7969 5298 Fax: +44(0)20 7436 6179 Fax: +44(0)20 7451 2692 Fax: +44(0)20 7611 8545 Email: E-mail: E-mail: E-mail: [email protected] [email protected] [email protected] [email protected] Web: www.acmedsci.ac.uk Web: www.mrc.ac.uk Web: www.royalsoc.ac.uk Web: www.wellcome.ac.uk December 2006 The use of non-human primates in research A working group report chaired by Sir David Weatheall FRS FMedSci December 2006 Sponsors’ statement The use of non-human primates continues to be one the most contentious areas of biological and medical research. The publication of this independent report into the scientific basis for the past, current and future role of non-human primates in research is both a necessary and timely contribution to the debate. We emphasise that members of the working group have worked independently of the four sponsoring organisations. Our organisations did not provide input into the report’s content, conclusions or recommendations. -
Masakazu Konishi
Masakazu Konishi BORN: Kyoto, Japan February 17, 1933 EDUCATION: Hokkaido University, Sapporo, Japan, B.S. (1956) Hokkaido University, Sapporo, Japan, M.S. (1958) University of California, Berkeley, Ph.D. (1963) APPOINTMENTS: Postdoctoral Fellow, University of Tübingen, Germany (1963–1964) Postdoctoral Fellow, Division of Experimental Neurophysiology, Max-Planck Institut, Munich, Germany (1964–1965) Assistant Professor of Biology, University of Wisconsin, Madison (1965–1966) Assistant Professor of Biology, Princeton University (1966–1970) Associate Professor of Biology, Princeton University (1970–1975) Professor of Biology, California Institute of Technology (1975– 1980) Bing Professor of Behavioral Biology, California Institute of Technology (1980– ) HONORS AND AWARDS (SELECTED): Member, American Academy of Arts and Sciences (1979) Member, National Academy of Sciences (1985) President, International Society for Neuroethology (1986—1989) F. O. Schmitt Prize (1987) International Prize for Biology (1990) The Lewis S. Rosenstiel Award, Brandeis University (2004) Edward M. Scolnick Prize in Neuroscience, MIT (2004) Gerard Prize, the Society for Neuroscience (2004) Karl Spencer Lashley Award, The American Philosophical Society (2004) The Peter and Patricia Gruber Prize in Neuroscience, The Society for Neuroscience (2005) Masakazu (Mark) Konishi has been one of the leaders in avian neuroethology since the early 1960’s. He is known for his idea that young birds initially remember a tutor song and use the memory as a template to guide the development of their own song. He was the fi rst to show that estrogen prevents programmed cell death in female zebra fi nches. He also pioneered work on the brain mechanisms of sound localization by barn owls. He has trained many students and postdoctoral fellows who became leading neuroethologists. -
Sensory Biology of Aquatic Animals
Jelle Atema Richard R. Fay Arthur N. Popper William N. Tavolga Editors Sensory Biology of Aquatic Animals Springer-Verlag New York Berlin Heidelberg London Paris Tokyo JELLE ATEMA, Boston University Marine Program, Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA Richard R. Fay, Parmly Hearing Institute, Loyola University, Chicago, Illinois 60626, USA ARTHUR N. POPPER, Department of Zoology, University of Maryland, College Park, MD 20742, USA WILLIAM N. TAVOLGA, Mote Marine Laboratory, Sarasota, Florida 33577, USA The cover Illustration is a reproduction of Figure 13.3, p. 343 of this volume Library of Congress Cataloging-in-Publication Data Sensory biology of aquatic animals. Papers based on presentations given at an International Conference on the Sensory Biology of Aquatic Animals held, June 24-28, 1985, at the Mote Marine Laboratory in Sarasota, Fla. Bibliography: p. Includes indexes. 1. Aquatic animals—Physiology—Congresses. 2. Senses and Sensation—Congresses. I. Atema, Jelle. II. International Conference on the Sensory Biology - . of Aquatic Animals (1985 : Sarasota, Fla.) QL120.S46 1987 591.92 87-9632 © 1988 by Springer-Verlag New York Inc. x —• All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer-Verlag, 175 Fifth Avenue, New York 10010, U.S.A.), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of Information storage and retrieval, electronic adaptation, Computer Software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use of general descriptive names, trade names, trademarks, etc. -
Neuroimaging and the "Complexity" of Capital Punishment O
Notre Dame Law School NDLScholarship Journal Articles Publications 2007 Neuroimaging and the "Complexity" of Capital Punishment O. Carter Snead Notre Dame Law School, [email protected] Follow this and additional works at: https://scholarship.law.nd.edu/law_faculty_scholarship Part of the Criminal Law Commons, Criminal Procedure Commons, and the Legal Ethics and Professional Responsibility Commons Recommended Citation O. C. Snead, Neuroimaging and the "Complexity" of Capital Punishment, 82 N.Y.U. L. Rev. 1265 (2007). Available at: https://scholarship.law.nd.edu/law_faculty_scholarship/542 This Article is brought to you for free and open access by the Publications at NDLScholarship. It has been accepted for inclusion in Journal Articles by an authorized administrator of NDLScholarship. For more information, please contact [email protected]. ARTICLES NEUROIMAGING AND THE "COMPLEXITY" OF CAPITAL PUNISHMENT 0. CARTER SNEAD* The growing use of brain imaging technology to explore the causes of morally, socially, and legally relevant behavior is the subject of much discussion and contro- versy in both scholarly and popular circles. From the efforts of cognitive neuros- cientists in the courtroom and the public square, the contours of a project to transform capital sentencing both in principle and in practice have emerged. In the short term, these scientists seek to play a role in the process of capitalsentencing by serving as mitigation experts for defendants, invoking neuroimaging research on the roots of criminal violence to support their arguments. Over the long term, these same experts (and their like-minded colleagues) hope to appeal to the recent find- ings of their discipline to embarrass, discredit, and ultimately overthrow retributive justice as a principle of punishment. -
The Impact of NMR and MRI
WELLCOME WITNESSES TO TWENTIETH CENTURY MEDICINE _____________________________________________________________________________ MAKING THE HUMAN BODY TRANSPARENT: THE IMPACT OF NUCLEAR MAGNETIC RESONANCE AND MAGNETIC RESONANCE IMAGING _________________________________________________ RESEARCH IN GENERAL PRACTICE __________________________________ DRUGS IN PSYCHIATRIC PRACTICE ______________________ THE MRC COMMON COLD UNIT ____________________________________ WITNESS SEMINAR TRANSCRIPTS EDITED BY: E M TANSEY D A CHRISTIE L A REYNOLDS Volume Two – September 1998 ©The Trustee of the Wellcome Trust, London, 1998 First published by the Wellcome Trust, 1998 Occasional Publication no. 6, 1998 The Wellcome Trust is a registered charity, no. 210183. ISBN 978 186983 539 1 All volumes are freely available online at www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/ Please cite as : Tansey E M, Christie D A, Reynolds L A. (eds) (1998) Wellcome Witnesses to Twentieth Century Medicine, vol. 2. London: Wellcome Trust. Key Front cover photographs, L to R from the top: Professor Sir Godfrey Hounsfield, speaking (NMR) Professor Robert Steiner, Professor Sir Martin Wood, Professor Sir Rex Richards (NMR) Dr Alan Broadhurst, Dr David Healy (Psy) Dr James Lovelock, Mrs Betty Porterfield (CCU) Professor Alec Jenner (Psy) Professor David Hannay (GPs) Dr Donna Chaproniere (CCU) Professor Merton Sandler (Psy) Professor George Radda (NMR) Mr Keith (Tom) Thompson (CCU) Back cover photographs, L to R, from the top: Professor Hannah Steinberg, Professor -
Advances in the Study of Behavior, Volume 31.Pdf
Advances in THE STUDY OF BEHAVIOR VOLUME 31 Advances in THE STUDY OF BEHAVIOR Edited by PETER J. B. S LATER JAY S. ROSENBLATT CHARLES T. S NOWDON TIMOTHY J. R OPER Advances in THE STUDY OF BEHAVIOR Edited by PETER J. B. S LATER School of Biology University of St. Andrews Fife, United Kingdom JAY S. ROSENBLATT Institute of Animal Behavior Rutgers University Newark, New Jersey CHARLES T. S NOWDON Department of Psychology University of Wisconsin Madison, Wisconsin TIMOTHY J. R OPER School of Biological Sciences University of Sussex Sussex, United Kingdom VOLUME 31 San Diego San Francisco New York Boston London Sydney Tokyo This book is printed on acid-free paper. ∞ Copyright C 2002 by ACADEMIC PRESS All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the Publisher. The appearance of the code at the bottom of the first page of a chapter in this book indicates the Publisher’s consent that copies of the chapter may be made for personal or internal use of specific clients. This consent is given on the condition, however, that the copier pay the stated per copy fee through the Copyright Clearance Center, Inc. (222 Rosewood Drive, Danvers, Massachusetts 01923), for copying beyond that permitted by Sections 107 or 108 of the U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. -
Leading History Elias A. Zerhouni, MD December 19, 2019
Episode 16: Leading History Elias A. Zerhouni, MD December 19, 2019 American College of Radiology, through its Radiology Leadership Institute (RLI), offers this podcast as one of a series of educational discussions with radiology leaders. The podcasts reflect the perspectives of the individual leaders, not of ACR or RLI. ACR disclaims liability for any acts or omissions that occur based on these discussions. Listeners may download the transcript for their own learning and share with their colleagues in their practices and departments. However, they may not copy and redistribute any portion of the podcast content for any commercial purpose. Episode 16: Leading History Elias A. Zerhouni, MD [00:00:01.282] Geoff: This month, we have an extra special holiday treat for you. As you will soon hear, Elias Zerhouni has had profoundly broad influence both within the field of radiology and well beyond it through the establishment of national policies for the organization and prioritization of health sciences research, advising international heads of state on science and technology strategy, facilitating the global availability of vaccines, and reorganizing one of the world's largest pharmaceutical companies to pivot from small molecule discovery to the development of therapeutic biologics. Elias Zerhouni has fearlessly approached his career as a series of professional disruptions that offer a lesson to us all in taking chances and making bold decisions. [00:00:51.453] No matter where you are in your career, as you listen to Elias's story, I invite you to reflect on your own journey and the decisions that you may be facing. -
THE MANY STEPS and EVOLUTION in the DEVELOPMENT of COMPUTED TOMOGRAPHY TECHNOLOGY and IMAGING METHODS, the QUEST for ENHANCED VISIBILITY the First Fifty Years
MEDICAL PHYSICS INTERNATIONAL Journal, Special Issue, History of Medical Physics 4, 2020 THE MANY STEPS AND EVOLUTION IN THE DEVELOPMENT OF COMPUTED TOMOGRAPHY TECHNOLOGY AND IMAGING METHODS, THE QUEST FOR ENHANCED VISIBILITY The First Fifty Years Perry Sprawls Emory University and Sprawls Educational Foundation, www.sprawls.org. USA • Abstract— Computed Tomography (CT) is considered the second most significant contribution of physics and technology to medicine following Roentgen’s discovery and introduction of x-ray imaging, radiography. CT is an x-ray imaging process but greatly extends the scope of structures, functions, and conditions within a human body that can be visualized for medical diagnosis. Compared to radiography CT provides two major advantages, It is a tomographic method that provides close viewing (within millimeters) of objects and locations within a human body without interference from overlying body sections. The second value is its high contrast sensitivity, the ability to produce visible contrast among different soft tissues, even when enclosed within a dense bony skull. The production of CT images is a sequence of two distinct phases. The first is scanning an x-ray beam around a patient body and measuring the total attenuation along different pathways through the slice of tissue that is to be imaged. This produces a data set consisting of large number (1000s) of measurements. The second phase is a mathematical process of calculating, generally referred to as “reconstructing” a digital image from the acquired data set. Allan Cormack, a physicist, first developed a mathematical process for calculating the distribution of x-ray attenuation values throughout a simulated body section. -
Early Days of CT: Innovations (Both Good and Bad)
Early Days of CT: Innovations (Both Good and Bad) Robert G. Gould Department of Radiology University of California San Francisco The Names: An Incomplete List • Johann Karl August Radon 1887‐1956 • William Henry Oldendorf 1925‐1992 • Allan McLeod Cormack 1919‐2004 • Godfrey Newbold Hounsfield 1919‐2004 • Robert Ledley 1924‐ Sir Godfrey Hounsfield • Elected to Royal Society 1975 • Nobel prize 1979 shared with Allan Cormack 1919‐2004 EMI Head Scanner First clinical image (Atkinson‐ Morley Hospital London EMI Head Scanner Dose information 1972 sales brochure EMI Head Scanner Geometry: Translate rotate, pencil beam Scan time: 4.5‐20 min Rotation Angle: 1° Number of views: 180 Samples per view: 160 Total samples: 28,800 Matrix: 80 x 80 FOV: 23.5 cm Pixel size: 3 x 3 mm Slice thickness: 13 mm or 8 mm X‐ray tube: Fixed anode Technique Factors: 100 (40), 120 (32), 140 (27) [ KVp (mA)] X‐Ray Controls Detectors: NaI‐PMT Cost: ~$350,000 Question: What machine was the first multislice CT? Answer: EMI head scanner! It had 2 detectors along the Z‐axis. EMI Head Scanner • ‘Print out scale’ + 500 First truly digital device in radiology 1972 sales brochure EMI Head Scanner 1972 sales brochure EMI: Rise and Fall 1971: Prototype head scanner installed at Atkinson Morley Hospital 1972: First clinical results presented by James Ambrose, MD on 70 patients 1973: Clinical production, two units installed in the US at Mayo Clinic and at MGH 1974: ACTA whole body scanner installed 1975: 3rd generation machines installed 1975: 10 companies now make CT scanners including