The Eye of the CT Scanner: the Story of Learning to See the Invisible Or
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12.2% 116,000 120M Top 1% 154 3,900
We are IntechOpen, the world’s leading publisher of Open Access books Built by scientists, for scientists 3,900 116,000 120M Open access books available International authors and editors Downloads Our authors are among the 154 TOP 1% 12.2% Countries delivered to most cited scientists Contributors from top 500 universities Selection of our books indexed in the Book Citation Index in Web of Science™ Core Collection (BKCI) Interested in publishing with us? Contact [email protected] Numbers displayed above are based on latest data collected. For more information visit www.intechopen.com Chapter Introductory Chapter: Veterinary Anatomy and Physiology Valentina Kubale, Emma Cousins, Clara Bailey, Samir A.A. El-Gendy and Catrin Sian Rutland 1. History of veterinary anatomy and physiology The anatomy of animals has long fascinated people, with mural paintings depicting the superficial anatomy of animals dating back to the Palaeolithic era [1]. However, evidence suggests that the earliest appearance of scientific anatomical study may have been in ancient Babylonia, although the tablets upon which this was recorded have perished and the remains indicate that Babylonian knowledge was in fact relatively limited [2]. As such, with early exploration of anatomy documented in the writing of various papyri, ancient Egyptian civilisation is believed to be the origin of the anatomist [3]. With content dating back to 3000 BCE, the Edwin Smith papyrus demonstrates a recognition of cerebrospinal fluid, meninges and surface anatomy of the brain, whilst the Ebers papyrus describes systemic function of the body including the heart and vas- culature, gynaecology and tumours [4]. The Ebers papyrus dates back to around 1500 bCe; however, it is also thought to be based upon earlier texts. -
Godfrey Hounsfield ”Each New Discovery Brings with It the Seeds of Other, Future Inventions”
HISTORY |ESSR Publications Godfrey Hounsfield ”Each new discovery brings with it the seeds of other, future inventions” By Iwona Sudoł-Szopińska (radiologist) and Marta Panas-Goworska (culture expert) 28 August was the 100th anniversary of the birth of Sir Godfrey Newbold Hounsfield. Godfrey Hounsfield was born on 28 August 1919 in Newark, England. His parents were farmers, and it was at their family farm where the talents of this Nobel Prize laureate showed for the first time. On his own, he mended various machines and even constructed a glider, which he did not forget to mention in his speech at the Nobel Prize gala in 1979: I made hazardous investigations of the principles of flight, launching myself from the tops of haystacks with a home-made glider; I almost blew myself up during exciting experiments using water-filled tar barrels and acetylene to see how high they could be propelled. It would seem that these skills would surely make him an outstanding student and later scientist. This, however, never happened. He was only average at school, and before World War II he enrolled voluntarily on the Royal Air Force (RAF), where he fathomed the arcana of electronics. After the war, owing to the support of his superiors from the army, he was accepted at the Faraday House Electrical Engineering College. This was not, however, a higher school of engineering as we understand it today, but rather a specialist school bridging vocational education with polytechnics that would appear later in the 1960s. This means that genius Godfrey Hounsfield was never formally an engineer and, although he worked in the area of broadly understood information technology, he would speak of his educational shortcomings with these words: You’ve got to use the absolute minimum of mathematics but have a tremendous lot of intuition. -
The Use of Non-Human Primates in Research in Primates Non-Human of Use The
The use of non-human primates in research The use of non-human primates in research A working group report chaired by Sir David Weatherall FRS FMedSci Report sponsored by: Academy of Medical Sciences Medical Research Council The Royal Society Wellcome Trust 10 Carlton House Terrace 20 Park Crescent 6-9 Carlton House Terrace 215 Euston Road London, SW1Y 5AH London, W1B 1AL London, SW1Y 5AG London, NW1 2BE December 2006 December Tel: +44(0)20 7969 5288 Tel: +44(0)20 7636 5422 Tel: +44(0)20 7451 2590 Tel: +44(0)20 7611 8888 Fax: +44(0)20 7969 5298 Fax: +44(0)20 7436 6179 Fax: +44(0)20 7451 2692 Fax: +44(0)20 7611 8545 Email: E-mail: E-mail: E-mail: [email protected] [email protected] [email protected] [email protected] Web: www.acmedsci.ac.uk Web: www.mrc.ac.uk Web: www.royalsoc.ac.uk Web: www.wellcome.ac.uk December 2006 The use of non-human primates in research A working group report chaired by Sir David Weatheall FRS FMedSci December 2006 Sponsors’ statement The use of non-human primates continues to be one the most contentious areas of biological and medical research. The publication of this independent report into the scientific basis for the past, current and future role of non-human primates in research is both a necessary and timely contribution to the debate. We emphasise that members of the working group have worked independently of the four sponsoring organisations. Our organisations did not provide input into the report’s content, conclusions or recommendations. -
Neuroimaging and the "Complexity" of Capital Punishment O
Notre Dame Law School NDLScholarship Journal Articles Publications 2007 Neuroimaging and the "Complexity" of Capital Punishment O. Carter Snead Notre Dame Law School, [email protected] Follow this and additional works at: https://scholarship.law.nd.edu/law_faculty_scholarship Part of the Criminal Law Commons, Criminal Procedure Commons, and the Legal Ethics and Professional Responsibility Commons Recommended Citation O. C. Snead, Neuroimaging and the "Complexity" of Capital Punishment, 82 N.Y.U. L. Rev. 1265 (2007). Available at: https://scholarship.law.nd.edu/law_faculty_scholarship/542 This Article is brought to you for free and open access by the Publications at NDLScholarship. It has been accepted for inclusion in Journal Articles by an authorized administrator of NDLScholarship. For more information, please contact [email protected]. ARTICLES NEUROIMAGING AND THE "COMPLEXITY" OF CAPITAL PUNISHMENT 0. CARTER SNEAD* The growing use of brain imaging technology to explore the causes of morally, socially, and legally relevant behavior is the subject of much discussion and contro- versy in both scholarly and popular circles. From the efforts of cognitive neuros- cientists in the courtroom and the public square, the contours of a project to transform capital sentencing both in principle and in practice have emerged. In the short term, these scientists seek to play a role in the process of capitalsentencing by serving as mitigation experts for defendants, invoking neuroimaging research on the roots of criminal violence to support their arguments. Over the long term, these same experts (and their like-minded colleagues) hope to appeal to the recent find- ings of their discipline to embarrass, discredit, and ultimately overthrow retributive justice as a principle of punishment. -
The Impact of NMR and MRI
WELLCOME WITNESSES TO TWENTIETH CENTURY MEDICINE _____________________________________________________________________________ MAKING THE HUMAN BODY TRANSPARENT: THE IMPACT OF NUCLEAR MAGNETIC RESONANCE AND MAGNETIC RESONANCE IMAGING _________________________________________________ RESEARCH IN GENERAL PRACTICE __________________________________ DRUGS IN PSYCHIATRIC PRACTICE ______________________ THE MRC COMMON COLD UNIT ____________________________________ WITNESS SEMINAR TRANSCRIPTS EDITED BY: E M TANSEY D A CHRISTIE L A REYNOLDS Volume Two – September 1998 ©The Trustee of the Wellcome Trust, London, 1998 First published by the Wellcome Trust, 1998 Occasional Publication no. 6, 1998 The Wellcome Trust is a registered charity, no. 210183. ISBN 978 186983 539 1 All volumes are freely available online at www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/ Please cite as : Tansey E M, Christie D A, Reynolds L A. (eds) (1998) Wellcome Witnesses to Twentieth Century Medicine, vol. 2. London: Wellcome Trust. Key Front cover photographs, L to R from the top: Professor Sir Godfrey Hounsfield, speaking (NMR) Professor Robert Steiner, Professor Sir Martin Wood, Professor Sir Rex Richards (NMR) Dr Alan Broadhurst, Dr David Healy (Psy) Dr James Lovelock, Mrs Betty Porterfield (CCU) Professor Alec Jenner (Psy) Professor David Hannay (GPs) Dr Donna Chaproniere (CCU) Professor Merton Sandler (Psy) Professor George Radda (NMR) Mr Keith (Tom) Thompson (CCU) Back cover photographs, L to R, from the top: Professor Hannah Steinberg, Professor -
Leading History Elias A. Zerhouni, MD December 19, 2019
Episode 16: Leading History Elias A. Zerhouni, MD December 19, 2019 American College of Radiology, through its Radiology Leadership Institute (RLI), offers this podcast as one of a series of educational discussions with radiology leaders. The podcasts reflect the perspectives of the individual leaders, not of ACR or RLI. ACR disclaims liability for any acts or omissions that occur based on these discussions. Listeners may download the transcript for their own learning and share with their colleagues in their practices and departments. However, they may not copy and redistribute any portion of the podcast content for any commercial purpose. Episode 16: Leading History Elias A. Zerhouni, MD [00:00:01.282] Geoff: This month, we have an extra special holiday treat for you. As you will soon hear, Elias Zerhouni has had profoundly broad influence both within the field of radiology and well beyond it through the establishment of national policies for the organization and prioritization of health sciences research, advising international heads of state on science and technology strategy, facilitating the global availability of vaccines, and reorganizing one of the world's largest pharmaceutical companies to pivot from small molecule discovery to the development of therapeutic biologics. Elias Zerhouni has fearlessly approached his career as a series of professional disruptions that offer a lesson to us all in taking chances and making bold decisions. [00:00:51.453] No matter where you are in your career, as you listen to Elias's story, I invite you to reflect on your own journey and the decisions that you may be facing. -
Critical Neuroscience and Philosophy
Critical Neuroscience and Philosophy A Scientific Re-Examination of the Mind-Body Problem David Låg Tomasi Critical Neuroscience and Philosophy “A ‘scientific re-examination of the mind-body problem’ is certainly a ‘difficult task’ and Tomasi seems to navigate the rough water with a safe methodological approach. The book provides the reader with a comprehensive overview, which exhibits a remarkable balance in the presentation of disputed topics. In addition, the author provides the necessary tools to have both people with science or phi- losophy backgrounds acquainted to the topic. Neuro-lovers will appreciate and learn from the presentation of the numerous neuroscience ‘sub-branches,’ together with details on the methodological approaches used in the neuroscience research. Philosophers will enjoy the freedom and degree of theoretical abstraction, unusual in neurobiology books. Tomasi does in fact analyse the ‘mind-body problem’ with a critical appraisal that combines the rigidness of the scientific method with the speculative insight and thoroughness of the philosophy. The combination of the two sources of knowledge makes this book a fundamental tool for those who share the need to bridge the (apparent) gap between science and philosophy. Another key adjective for describing the book is multidisciplinary. The author spans from logic to quantum mechanics, from medicine to informatics, from reli- gion to ethics, from theory to practice. In all the cases the rigor in defining critical words makes even a lay reader feel like taken by the hand during the journey.” —Francesco Orzi, Professor of Neurology, Sapienza University of Rome (retired), and member of the Accademia dei Fisiocritici, Siena, Italy “Critical Neuroscience and Philosophy is impressive in many ways—from the scope and variety of information analyzed to the inspiration that scientists, philosophers, and the wider public will find in it. -
THE MANY STEPS and EVOLUTION in the DEVELOPMENT of COMPUTED TOMOGRAPHY TECHNOLOGY and IMAGING METHODS, the QUEST for ENHANCED VISIBILITY the First Fifty Years
MEDICAL PHYSICS INTERNATIONAL Journal, Special Issue, History of Medical Physics 4, 2020 THE MANY STEPS AND EVOLUTION IN THE DEVELOPMENT OF COMPUTED TOMOGRAPHY TECHNOLOGY AND IMAGING METHODS, THE QUEST FOR ENHANCED VISIBILITY The First Fifty Years Perry Sprawls Emory University and Sprawls Educational Foundation, www.sprawls.org. USA • Abstract— Computed Tomography (CT) is considered the second most significant contribution of physics and technology to medicine following Roentgen’s discovery and introduction of x-ray imaging, radiography. CT is an x-ray imaging process but greatly extends the scope of structures, functions, and conditions within a human body that can be visualized for medical diagnosis. Compared to radiography CT provides two major advantages, It is a tomographic method that provides close viewing (within millimeters) of objects and locations within a human body without interference from overlying body sections. The second value is its high contrast sensitivity, the ability to produce visible contrast among different soft tissues, even when enclosed within a dense bony skull. The production of CT images is a sequence of two distinct phases. The first is scanning an x-ray beam around a patient body and measuring the total attenuation along different pathways through the slice of tissue that is to be imaged. This produces a data set consisting of large number (1000s) of measurements. The second phase is a mathematical process of calculating, generally referred to as “reconstructing” a digital image from the acquired data set. Allan Cormack, a physicist, first developed a mathematical process for calculating the distribution of x-ray attenuation values throughout a simulated body section. -
Early Days of CT: Innovations (Both Good and Bad)
Early Days of CT: Innovations (Both Good and Bad) Robert G. Gould Department of Radiology University of California San Francisco The Names: An Incomplete List • Johann Karl August Radon 1887‐1956 • William Henry Oldendorf 1925‐1992 • Allan McLeod Cormack 1919‐2004 • Godfrey Newbold Hounsfield 1919‐2004 • Robert Ledley 1924‐ Sir Godfrey Hounsfield • Elected to Royal Society 1975 • Nobel prize 1979 shared with Allan Cormack 1919‐2004 EMI Head Scanner First clinical image (Atkinson‐ Morley Hospital London EMI Head Scanner Dose information 1972 sales brochure EMI Head Scanner Geometry: Translate rotate, pencil beam Scan time: 4.5‐20 min Rotation Angle: 1° Number of views: 180 Samples per view: 160 Total samples: 28,800 Matrix: 80 x 80 FOV: 23.5 cm Pixel size: 3 x 3 mm Slice thickness: 13 mm or 8 mm X‐ray tube: Fixed anode Technique Factors: 100 (40), 120 (32), 140 (27) [ KVp (mA)] X‐Ray Controls Detectors: NaI‐PMT Cost: ~$350,000 Question: What machine was the first multislice CT? Answer: EMI head scanner! It had 2 detectors along the Z‐axis. EMI Head Scanner • ‘Print out scale’ + 500 First truly digital device in radiology 1972 sales brochure EMI Head Scanner 1972 sales brochure EMI: Rise and Fall 1971: Prototype head scanner installed at Atkinson Morley Hospital 1972: First clinical results presented by James Ambrose, MD on 70 patients 1973: Clinical production, two units installed in the US at Mayo Clinic and at MGH 1974: ACTA whole body scanner installed 1975: 3rd generation machines installed 1975: 10 companies now make CT scanners including -
CT, MRI, and DTI a Filler
The Internet Journal of Neurosurgery ISPUB.COM Volume 7 Number 1 The History, Development and Impact of Computed Imaging in Neurological Diagnosis and Neurosurgery: CT, MRI, and DTI A Filler Citation A Filler. The History, Development and Impact of Computed Imaging in Neurological Diagnosis and Neurosurgery: CT, MRI, and DTI. The Internet Journal of Neurosurgery. 2009 Volume 7 Number 1. Abstract A steady series of advances in physics, mathematics, computers and clinical imaging science have progressively transformed diagnosis and treatment of neurological and neurosurgical disorders in the 115 years between the discovery of the X-ray and the advent of high resolution diffusion based functional MRI. The story of the progress in human terms, with its battles for priorities, forgotten advances, competing claims, public battles for Nobel Prizes, and patent priority litigations bring alive the human drama of this remarkable collective achievement in computed medical imaging. BACKGROUND shimmering appearance on a computer screen of a view of Atkinson Morley's Hospital is a small Victorian era hospital the human body that no one else had seen before. building standing high on a hill top in Wimbledon, about 8 Because of the complexity of computed imaging techniques, miles southwest of the original St. George's Hospital their history has remarkable depth and breadth. The building site in central London. On October 1, 1971 Godfrey mathematical basis of MRI relies on the work of Fourier - Hounsfield and Jamie Ambrose positioned a patient inside a which he started in Cairo while serving as a scientific new machine in the basement of the hospital turned a switch participant in Napoleon's invasion of Egypt in 1801. -
Discovery of the Secrets of Life Timeline
Discovery of the Secrets of Life Timeline: A Chronological Selection of Discoveries, Publications and Historical Notes Pertaining to the Development of Molecular Biology. Copyright 2010 Jeremy M. Norman. Date Discovery or Publication References Crystals of plant and animal products do not typically occur naturally. F. Lesk, Protein L. Hünefeld accidentally observes the first protein crystals— those of Structure, 36;Tanford 1840 hemoglobin—in a sample of dried menstrual blood pressed between glass & Reynolds, Nature’s plates. Hunefeld, Der Chemismus in der thierischen Organisation, Robots, 22.; Judson, Leipzig: Brockhaus, 1840, 158-63. 489 In his dissertation Louis Pasteur begins a series of “investigations into the relation between optical activity, crystalline structure, and chemical composition in organic compounds, particularly tartaric and paratartaric acids. This work focused attention on the relationship between optical activity and life, and provided much inspiration and several of the most 1847 HFN 1652; Lesk 36 important techniques for an entirely new approach to the study of chemical structure and composition. In essence, Pasteur opened the way to a consideration of the disposition of atoms in space.” (DSB) Pasteur, Thèses de Physique et de Chimie, Presentées à la Faculté des Sciences de Paris. Paris: Bachelier, 1847. Otto Funcke (1828-1879) publishes illustrations of crystalline 1853 hemoglobin of horse, humans and other species in his Atlas der G-M 684 physiologischen Chemie, Leizpig: W. Englemann, 1853. Charles Darwin and Alfred Russel Wallace publish the first exposition of the theory of natural selection. Darwin and Wallace, “On the Tendency of 1858 Species to Form Varieties, and on the Perpetuation of Varieties and G-M 219 Species by Natural Means of Selection,” J. -
Contributions of Civilizations to International Prizes
CONTRIBUTIONS OF CIVILIZATIONS TO INTERNATIONAL PRIZES Split of Nobel prizes and Fields medals by civilization : PHYSICS .......................................................................................................................................................................... 1 CHEMISTRY .................................................................................................................................................................... 2 PHYSIOLOGY / MEDECINE .............................................................................................................................................. 3 LITERATURE ................................................................................................................................................................... 4 ECONOMY ...................................................................................................................................................................... 5 MATHEMATICS (Fields) .................................................................................................................................................. 5 PHYSICS Occidental / Judeo-christian (198) Alekseï Abrikossov / Zhores Alferov / Hannes Alfvén / Eric Allin Cornell / Luis Walter Alvarez / Carl David Anderson / Philip Warren Anderson / EdWard Victor Appleton / ArthUr Ashkin / John Bardeen / Barry C. Barish / Nikolay Basov / Henri BecqUerel / Johannes Georg Bednorz / Hans Bethe / Gerd Binnig / Patrick Blackett / Felix Bloch / Nicolaas Bloembergen