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PRODUCT INFORMATION Nadifloxacin Item No. 20252 CAS Registry No.: 124858-35-1 O Formal Name: 9-fluoro-6,7-dihydro-8-(4-hydroxy-1- piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij] HO N quinolizine-2-carboxylic acid Synonym: OPC 7251 O MF: C19H21FN2O4 FW: 360.4 Purity: ≥98% N UV/Vis.: λ: 216, 235, 295, 321 nm max F Supplied as: A crystalline solid OH Storage: -20°C Stability: As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly Laboratory Procedures Nadifloxacin is supplied as a crystalline solid. A stock solution may be made by dissolving the nadifloxacin in the solvent of choice. Nadifloxacin is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of nadifloxacin in these solvents is approximately 0.25, 20, and 25 mg/ml, respectively. Description Nadifloxacin is a fluoroquinolone antibiotic that is used topically. It is effective against the Gram-positive bacteria S. aureus and P. acnes, as well as Gram-negative bacteria.1-3 References 1. Takei, M., Fukuda, H., Kishii, R., et al. Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition. Antimicrob. Agents Chemother. 45(12), 3544-3547 (2001). 2. Kaur, J., Sehgal, V. K., Gupta, A. K., et al. A comparative study to evaluate the efficacy and safety of combination topical preparations in acne vulgaris. Int. J. Appl. Basic Med.Res. 5(2), 106-110 (2015). 3. Narayanan, V., Motlekar, S., Kadhe, G., et al. Efficacy and safety of nadifloxacin for bacterial skin infections: Results from clinical and post-marketing studies. Dermatol. Ther. (Heidelb.) 4(2), 233-248 (2014). WARNING CAYMAN CHEMICAL THIS PRODUCT IS FOR RESEARCH ONLY - NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. 1180 EAST ELLSWORTH RD SAFETY DATA ANN ARBOR, MI 48108 · USA This material should be considered hazardous until further information becomes available. Do not ingest, inhale, get in eyes, on skin, or on clothing. Wash thoroughly after handling. Before use, the user must review the complete Safety Data Sheet, which has been sent via email to your institution. PHONE: [800] 364-9897 WARRANTY AND LIMITATION OF REMEDY [734] 971-3335 Buyer agrees to purchase the material subject to Cayman’s Terms and Conditions. Complete Terms and Conditions including Warranty and Limitation of Liability information can be found on our website. FAX: [734] 971-3640 [email protected] Copyright Cayman Chemical Company, 09/23/2016 WWW.CAYMANCHEM.COM.

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Fluoroquinolones in Children: a Review of Current Literature and Directions for Future Research
Academic Year 2015 - 2016 Fluoroquinolones in children: a review of current literature and directions for future research Laurens GOEMÉ Promotor: Prof. Dr. Johan Vande Walle Co-promotor: Dr. Kevin Meesters, Dr. Pauline De Bruyne Dissertation presented in the 2nd Master year in the programme of Master of Medicine in Medicine 1 Deze pagina is niet beschikbaar omdat ze persoonsgegevens bevat. Universiteitsbibliotheek Gent, 2021. This page is not available because it contains personal information. Ghent Universit , Librar , 2021. Table of contents Title page Permission for loan Introduction Page 4-6 Methodology Page 6-7 Results Page 7-20 1. Evaluation of found articles Page 7-12 2. Fluoroquinolone characteristics in children Page 12-20 Discussion Page 20-23 Conclusion Page 23-24 Future perspectives Page 24-25 References Page 26-27 3 1. Introduction Fluoroquinolones (FQ) are a class of antibiotics, derived from modification of quinolones, that are highly active against both Gram-positive and Gram-negative bacteria. In 1964,naladixic acid was approved by the US Food and Drug Administration (FDA) as first quinolone (1). Chemical modifications of naladixic acid resulted in the first generation of FQ. The antimicrobial spectrum of FQ is broader when compared to quinolones and the tissue penetration of FQ is significantly deeper (1). The main FQ agents are summed up in table 1. FQ owe its antimicrobial effect to inhibition of the enzymes bacterial gyrase and topoisomerase IV which have essential and distinct roles in DNA replication. The antimicrobial spectrum of FQ include Enterobacteriacae, Haemophilus spp., Moraxella catarrhalis, Neiserria spp. and Pseudomonas aeruginosa (1). And FQ usually have a weak activity against methicillin-resistant Staphylococcus aureus (MRSA).
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Drug Name Plate Number Well Location % Inhibition, Screen Axitinib 1 1 20 Gefitinib (ZD1839) 1 2 70 Sorafenib Tosylate 1 3 21 Cr
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A Randomized, Double-Blind Comparison of Nadifloxacin 1
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International Journal of Contemporary Pediatrics Janbandhu S et al. Int J Contemp Pediatr. 2020 Feb;7(2):236-242 http://www.ijpediatrics.com pISSN 2349-3283 | eISSN 2349-3291 DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20200097 Original Research Article An evaluation of safety and efficacy of nadifloxacin 1% ointment versus mupirocin 1% ointment in Indian children with skin and soft tissue infection Swapnil Janbandhu1, Sushil Chaudhary1, Sunil Chaudhary1, Gaurav Puppalwar2*, Rishi Jain2 1Department of Pediatrics, Lifepoint Multispeciality Hospital, Pune, Maharashtra, India 2Department of Medical Affairs, Wockhardt Limited, Mumbai, Maharashtra, India Received: 06 October 2019 Revised: 16 November 2019 Accepted: 06 December 2019 *Correspondence: Dr. Gaurav Puppalwar, E-mail: [email protected] Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background: Although nadifloxacin has been shown to be effective in the treatment of skin & soft tissue infections (SSTI), there is a paucity of data comparing its efficacy and safety with other antibacterials, especially in Indian paediatric population. Therefore, objective of this study was to compare the safety and efficacy of nadifloxacin with mupirocin in children with SSTI. Methods: This was a single-centre, open label, randomized, parallel group, comparative study in 60 children of <12 years of age with SSTI. Test group (n=30) received nadifloxacin 1% ointment and reference group (n=30) received mupirocin 1% ointment, to be applied twice daily.
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IJDVL Acne 09.Indd
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National OTC Medicines List
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EMA/CVMP/158366/2019 Committee for Medicinal Products for Veterinary Use
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Resistance Status of Antibiotics in Gram-Positive Bacteria Isolated
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ATC-Index Mit DDD-Angaben Für Den Deutschen Arzneimittelmarkt 5
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Jebmh.Com Original Research Article
Jebmh.com Original Research Article A RATIONAL PHARMACOTHERAPEUTIC STUDY IN PHARMACOVIGILANCE: A COMPARATIVE ASSESSMENT OF SAFETY BETWEEN TOPICAL 1% NADIFLOXACIN AND 0.1% ADAPALENE COMBINATION THERAPY AND TOPICAL 1% NADIFLOXACIN AND 0.025% TRETINOIN COMBINATION THERAPY, IN MILD TO MODERATE ACNE, IN TERTIARY CARE HOSPITALS, IN INDIA Moumita Hazra1 1Assistant Professor, Department of Pharmacology, K. D. Medical College, Hospital and Research Centre, Mathura, Uttar Pradesh. ABSTRACT BACKGROUND Topical adapalene and tretinoin, are comedolytic, anti-comedogenic and anti-inflammatory, on RAR (α, β, ℽ) receptors binding. Due to higher chemical stability, lipophilicity and lesser photo-lability, adapalene enables quicker follicular penetration, by lesser anti-AP-1 (c-Jun, c-Fos) and no CRBPII mRNA action, thus producing lesser photosensitivity and no skin irritation, unlike tretinoin; in which, these are reducible by overnight application, combination therapy, slow-release polymers or emollients. Topical nadifloxacin is bactericidal, anti-inflammatory and comedolytic, with inhibitory effect on DNA gyrase, DNA topoisomerase IV and IL-1α, IL-6, IL-8. The Global Alliance to Improve Outcomes in Acne guidelines recommend synergistic and additive combination therapies, which enhance therapeutic efficacy and reduce adverse effects. Due to inadequacy of data, this study was conducted, to compare the safety between topical 1% nadifloxacin and 0.1% adapalene combination therapy and topical 1% nadifloxacin and 0.025% tretinoin combination therapy, in mild to moderate acne, in tertiary care hospitals, in India. METHODS Groups A and B (50 patients each), applied topical 1% nadifloxacin and 0.1% adapalene combination therapy and 1% nadifloxacin and 0.025% tretinoin combination therapy, respectively, over their mild to moderate facial acne lesions, once daily overnight; and adverse effects, like erythema, scaling, dryness, pruritus, burning or stinging, were assessed on 0, 15, 30, 60, 90 days and follow-ups, by Local Irritation Scale.
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