PRODUCT INFORMATION Nadifloxacin Item No. 20252 CAS Registry No.: 124858-35-1 O Formal Name: 9-fluoro-6,7-dihydro-8-(4-hydroxy-1- piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij] HO N quinolizine-2-carboxylic acid Synonym: OPC 7251 O MF: C19H21FN2O4 FW: 360.4 Purity: ≥98% N UV/Vis.: λ: 216, 235, 295, 321 nm max F Supplied as: A crystalline solid OH Storage: -20°C Stability: As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly Laboratory Procedures Nadifloxacin is supplied as a crystalline solid. A stock solution may be made by dissolving the nadifloxacin in the solvent of choice. Nadifloxacin is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of nadifloxacin in these solvents is approximately 0.25, 20, and 25 mg/ml, respectively. Description Nadifloxacin is a fluoroquinolone antibiotic that is used topically. It is effective against the Gram-positive bacteria S. aureus and P. acnes, as well as Gram-negative bacteria.1-3 References 1. Takei, M., Fukuda, H., Kishii, R., et al. Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition. Antimicrob. Agents Chemother. 45(12), 3544-3547 (2001). 2. Kaur, J., Sehgal, V. K., Gupta, A. K., et al. A comparative study to evaluate the efficacy and safety of combination topical preparations in acne vulgaris. Int. J. Appl. Basic Med.Res. 5(2), 106-110 (2015). 3. Narayanan, V., Motlekar, S., Kadhe, G., et al. Efficacy and safety of nadifloxacin for bacterial skin infections: Results from clinical and post-marketing studies. Dermatol. Ther. (Heidelb.) 4(2), 233-248 (2014). WARNING CAYMAN CHEMICAL THIS PRODUCT IS FOR RESEARCH ONLY - NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. 1180 EAST ELLSWORTH RD SAFETY DATA ANN ARBOR, MI 48108 · USA This material should be considered hazardous until further information becomes available. Do not ingest, inhale, get in eyes, on skin, or on clothing. Wash thoroughly after handling. Before use, the user must review the complete Safety Data Sheet, which has been sent via email to your institution. PHONE: [800] 364-9897 WARRANTY AND LIMITATION OF REMEDY [734] 971-3335 Buyer agrees to purchase the material subject to Cayman’s Terms and Conditions. Complete Terms and Conditions including Warranty and Limitation of Liability information can be found on our website. FAX: [734] 971-3640 [email protected] Copyright Cayman Chemical Company, 09/23/2016 WWW.CAYMANCHEM.COM.