Table SI. a Total of 643 Proteins Were Identified by Tandem Mass Spectrometry in the Microvesicles/Exosomes from Patients with ABE

Table SI. A total of 643 proteins were identified by tandem mass spectrometry in the microvesicles/exosomes from patients with ABE.

Accession Description Coverage PS Unique AAs Molecular Calc. pI Abundance ratio: Abundance ratio: Score Sequest

no. Peptides Ms Peptides weight (kDa) Moderate/ Severe/ control HT

control

P01024 Complement C3 85.68851 132 228 127 1663 187.03 6.4 1.12 1.131 8141.004593

P0C0L5 Complement C4-B 66.80046 89 128 1 1744 192.631 7.27 2.106 1.249 4859.406727

P01023 Alpha-2-macroglobulin 63.83989 76 140 76 1474 163.188 6.46 1.021 0.972 5149.27648

P02751 Fibronectin 56.03521 87 960 87 2386 262.46 5.71 0.805 1.005 3458.332983

P02768 Serum albumin 79.31034 54 104 54 609 69.321 6.28 1.157 1.086 3705.267895

P08603 Complement factor H 58.4078 60 544 55 1231 139.005 6.61 1.02 0.979 1917.082723

Q9Y6R7 IgGFc-binding protein 27.71508 68 305 68 5405 571.639 5.34 1.527 1.04 981.3557811

P04114 Apolipoprotein B-100 33.66206 124 255 124 4563 515.283 7.05 1.055 1.057 753.3890735

Q12860 Contactin-1 56.87623 46 242 46 1018 113.249 5.9 0.747 0.963 816.1462975

A0A0A0M Immunoglobulin heavy 55.6391 23 124 12 399 43.884 6.96 1.206 1.104 4833.498744

S08 constant gamma 1 (Fragment) 7 P01031 Complement C5 44.98807 66 254 66 1676 188.186 6.52 1.224 1.241 804.1478994

P23142 Fibulin-1 57.32575 26 297 10 703 77.162 5.22 0.812 0.946 1110.052139

O00533 Neural cell adhesion molecule 42.88079 38 220 37 1208 134.987 5.76 0.789 0.827 804.1383946

L1-like protein

B4DPQ0 cDNA FLJ54471, highly 53.82476 30 278 30 719 81.837 6.37 0.995 0.971 923.9868439

similar to Complement C1r

subcomponent (EC 3.4.21.41)

B1AHL2 Fibulin-1 45.21498 22 313 6 721 78.277 5.39 0.738 0.874 1163.650674

P12111 Collagen alpha-3(VI) chain 28.0768 67 142 1 3177 343.457 6.68 1.317 1.101 483.426379

E7ENL6 Collagen alpha-3(VI) chain 34.41028 67 142 1 2569 277.946 8.18 0.891 0.884 483.3237839

P09871 Complement C1s 50.72674 27 217 26 688 76.635 4.96 1.046 0.992 778.6229264

subcomponent

P02787 Serotransferrin 58.88252 41 155 41 698 77.014 7.12 0.913 0.967 532.2420925

P02647 Apolipoprotein A-I 77.15356 24 385 24 267 30.759 5.76 1.315 1.057 1253.797316

P02675 Fibrinogen beta chain 71.2831 28 168 28 491 55.892 8.27 1.531 1.35 564.475502

P10643 Complement component C7 50.05931 29 156 29 843 93.457 6.48 0.712 0.872 573.7836608

A0A286YE Immunoglobulin heavy 54.43038 17 719 8 395 43.778 6.52 1.565 0.874 2565.892901

Y4 constant gamma 2 (Fragment) Q99435 Protein kinase C-binding 49.63235 30 216 30 816 91.284 5.73 0.846 0.823 715.4273092

protein NELL2

P22105 Tenascin-X 28.26497 72 124 72 4242 457.932 5.17 0.939 1.003 393.8049548

B4E1Z4 cDNA FLJ55673, highly 39.9684 46 160 29 1266 140.853 7.18 0.612 0.611 494.6025889

similar to Complement factor

B (EC 3.4.21.47)

P01860 Immunoglobulin heavy 61.00796 20 778 8 377 41.26 7.9 0.814 0.785 2633.157825

constant gamma 3

Q92823 Neuronal cell adhesion 37.88344 35 146 35 1304 143.8 5.66 0.798 0.878 513.597772

molecule

Q15113 Procollagen C-endopeptidase 57.23831 21 185 21 449 47.942 7.43 0.916 1.052 723.5592999

enhancer 1

P00747 Plasminogen 47.16049 36 139 36 810 90.51 7.24 1.17 1.084 485.4632403

P13645 Keratin, type I cytoskeletal 10 62.84247 32 125 29 584 58.792 5.21 0.767 0.9 416.226961

P02452 Collagen alpha-1(I) chain 23.01913 25 186 25 1464 138.857 5.8 0.879 0.96 644.1995287

P02649 Apolipoprotein E 80.12618 30 492 30 317 36.132 5.73 0.877 1.037 1639.833651

A0A286YF Immunoglobulin heavy 49.49495 14 371 6 396 43.804 6.24 1.412 1.43 1384.943221

J8 constant gamma 4 (Fragment)

P06396 Gelsolin 43.47826 28 173 28 782 85.644 6.28 0.852 0.91 630.3224766 Q7Z7M0 Multiple epidermal growth 20.0703 40 121 40 2845 302.901 6.87 0.785 1.009 432.9133862

factor-like domains protein 8

P14543 Nidogen-1 41.94066 38 129 37 1247 136.291 5.29 0.883 1.072 452.404595

E7ERL8 Neurexin-1-beta 36.09821 39 126 28 1507 165.341 5.96 0.802 0.996 392.0663251

P24043 Laminin subunit alpha-2 21.10826 58 100 58 3122 343.684 6.4 0.877 0.94 306.6071104

P06727 Apolipoprotein A-IV 75.75758 31 154 31 396 45.371 5.38 0.481 0.587 511.2329108

Q08380 Galectin-3-binding protein 44.2735 22 188 22 585 65.289 5.27 0.777 1.24 656.6998068

Q15063 Periostin 51.07656 34 103 3 836 93.255 7.53 0.921 1.074 346.0569105

B1ALD9 Periostin 49.75248 32 102 1 808 90.087 7.94 0.926 0.956 337.5734499

P04264 Keratin, type II cytoskeletal 1 43.47826 27 137 24 644 65.999 8.12 0.737 0.926 416.9153267

E7EUF1 Ectonucleotide 35.181 26 116 26 884 101.488 7.53 0.804 1.155 414.4653013

pyrophosphatase/phosphodies

terase family member 2

P08123 Collagen alpha-2(I) chain 21.52269 22 125 22 1366 129.235 8.95 0.915 0.975 444.3861085

P01834 Immunoglobulin kappa 80.37383 6 655 6 107 11.758 6.52 1.299 1.106 2588.88807

constant

P02671 Fibrinogen alpha chain 32.10162 24 118 24 866 94.914 6.01 1.342 1.368 365.6363721

A0A0A0M Receptor-type tyrosine-protein 25.31561 25 87 3 1505 168.814 6.48 0.859 0.887 297.8582029 R60 phosphatase S

Q12805 EGF-containing fibulin-like 50.10142 19 91 5 493 54.604 5.07 0.84 1.058 345.0832398

extracellular matrix protein 1

P55058 Phospholipid transfer protein 43.61055 17 88 17 493 54.705 7.01 1.004 1.027 322.0597194

P10909 Clusterin 37.86192 19 259 19 449 52.461 6.27 0.728 1.193 816.842995

P00734 Prothrombin 49.19614 24 71 24 622 69.992 5.9 0.876 0.832 257.8331151

Q86VB7 Scavenger receptor cysteine- 34.77509 29 98 29 1156 125.369 5.95 1.115 0.757 329.5928527

rich type 1 protein M130

Q13332 Receptor-type tyrosine-protein 18.94251 23 80 1 1948 216.905 6.46 0.9 1.113 268.2885706

phosphatase S

Q15582 Transforming growth factor- 46.99854 23 92 23 683 74.634 7.71 1.039 1.077 302.8436617

beta-induced protein ig-h3

M0R0Q9 Complement C3 (Fragment) 84.15842 6 130 1 101 11.148 4.77 0.981 1.178 506.8810011

P02461 Collagen alpha-1(III) chain 15.27967 19 125 18 1466 138.479 6.61 1.027 0.951 404.4664441

P0DOY2 Immunoglobulin lambda 93.39623 9 391 2 106 11.287 7.24 1.149 0.946 1610.298396

constant 2

P02679 Fibrinogen gamma chain 52.98013 22 105 14 453 51.479 5.62 1.478 1.394 307.4672016

G3XAI2 Laminin subunit beta-1 26.79558 39 77 39 1810 200.347 4.96 0.84 0.879 235.8733978 P51693 Amyloid-like protein 1 28.61538 18 106 18 650 72.131 5.8 0.746 0.922 398.4112236

Q9P2S2 Neurexin-2 26.10981 37 96 33 1712 184.865 5.92 0.844 1.013 317.2764077

A0A0B4J23 Immunoglobulin lambda-like 49.76744 10 315 3 215 23.136 8.84 0.884 0.984 1260.790692

1 polypeptide 5

P14618 Pyruvate kinase PKM 52.54237 24 79 9 531 57.9 7.84 1.047 0.948 286.2856965

P01034 Cystatin-C 62.32877 8 103 8 146 15.789 8.75 0.764 1.149 433.4969542

Q92859 Neogenin 23.54552 29 70 29 1461 159.917 6.54 0.851 0.99 225.9264209

P10586 Receptor-type tyrosine-protein 19.45464 26 60 11 1907 212.744 6.3 0.879 0.955 218.8161631

phosphatase F

P23468 Receptor-type tyrosine-protein 19.66527 27 61 2 1912 214.625 6.57 0.749 0.821 204.8723233

phosphatase delta

A0A1W2P Contactin-2 31.6129 24 61 24 1085 118.208 7.55 0.846 1.038 210.001472

Q11

P35908 Keratin, type II cytoskeletal 2 51.3302 28 89 20 639 65.393 8 0.733 0.834 274.1373594

epidermal

Q3KPI9 PTPRD protein 24.06417 26 59 1 1496 168.559 6.71 0.885 0.903 197.0752573

A0A0U1RR Neurexin-3-beta 23.9338 29 72 24 1571 173.549 6.15 0.888 0.979 209.8694506

J0 P35527 Keratin, type I cytoskeletal 9 39.9679 21 74 20 623 62.027 5.24 0.81 0.925 218.3285863

O14594 Neurocan core protein 19.15216 23 77 22 1321 143.003 5.38 0.866 0.936 253.315281

A0A0U1RQ EGF-containing fibulin-like 72.5 15 69 1 280 31.736 6.62 0.935 1.024 257.903069

V3 extracellular matrix protein 1

(Fragment)

P36955 Pigment epithelium-derived 46.17225 16 74 16 418 46.283 6.38 0.959 1.027 253.0521644

factor

O94985 Calsyntenin-1 26.91131 25 69 25 981 109.724 4.91 0.873 0.964 212.9554882

P98160 Basement membrane-specific 9.678889 31 59 31 4391 468.532 6.51 0.936 0.983 185.1466975

heparan sulfate proteoglycan

core protein

P13671 Complement component C6 35.11777 25 61 25 934 104.718 6.76 1.002 1.028 192.3045006

P01009 Alpha-1-antitrypsin 46.65072 20 69 20 418 46.707 5.59 0.889 0.827 223.3318003

H3BR70 Pyruvate kinase 55.7377 19 62 4 366 40.164 8.03 0.867 0.891 216.4689045

P19827 Inter-alpha-trypsin inhibitor 26.78375 18 58 18 911 101.326 6.79 1.088 0.901 202.5168812

heavy chain H1

P06681 Complement C2 34.17553 24 62 7 752 83.214 7.42 1.09 1.018 210.9730308

P19823 Inter-alpha-trypsin inhibitor 28.96406 23 69 23 946 106.397 6.86 1.071 1.006 213.0384146

heavy chain H2 V9GYM3 Apolipoprotein A-II 48.1203 7 104 7 133 14.905 8.27 1.219 1.338 382.2305138

P11047 Laminin subunit gamma-1 21.44189 31 53 31 1609 177.489 5.12 0.79 0.879 167.0971448

B7ZKJ8 ITIH4 protein 29.30481 22 57 22 935 103.816 6.89 0.976 0.855 195.2793177

P32004 Neural cell adhesion molecule 28.00318 31 58 30 1257 139.915 6.24 0.816 0.997 165.0750264

P07358 Complement component C8 35.8714 17 46 17 591 67.003 8.13 0.913 1.098 151.0469677

beta chain

P12109 Collagen alpha-1(VI) chain 26.84825 22 56 22 1028 108.462 5.43 0.869 1.101 173.1234797

P04004 Vitronectin 33.2636 13 89 13 478 54.271 5.8 0.875 1.018 282.3141191

P35555 Fibrillin-1 14.45489 34 52 32 2871 312.022 4.93 0.902 0.98 135.9623934

Q96GW7 Brevican core protein 32.05269 21 54 20 911 99.056 4.64 0.863 1.219 142.861371

P01871 Immunoglobulin heavy 52.98013 19 67 19 453 49.409 6.77 1.057 1.12 209.8624344

constant mu

A0A0A0M Coagulation factor V 14.35621 26 52 26 2229 252.078 6.05 0.884 1.031 140.9423827

RJ7

Q8TEU8 WAP, Kazal, immunoglobulin, 33.50694 15 41 15 576 63.898 6.21 0.767 0.78 130.4619564

Kunitz and NTR domain-

containing protein 2 Q14112 Nidogen-2 18.98182 22 46 4 1375 151.158 5.29 0.939 1.007 149.3320858

Q16610 Extracellular matrix protein 1 37.40741 15 50 15 540 60.635 6.71 0.922 0.818 163.9129673

P98095 Fibulin-2 24.49324 20 48 20 1184 126.489 4.82 0.856 0.957 138.3754125

P02745 Complement C1q 28.97959 6 48 6 245 26 9.11 1.142 0.981 217.802438

subcomponent subunit A

P60709 Actin, cytoplasmic 1 37.06667 10 39 4 375 41.71 5.48 1.239 0.927 141.0285643

A0M8Q6 Immunoglobulin lambda 62.26415 6 286 2 106 11.247 8.29 1.175 1.633 1252.272737

constant 7

Q9Y6N7 Roundabout homolog 1 17.08056 20 49 18 1651 180.818 6.04 0.954 0.97 139.4877369

P13611 Versican core protein 6.537102 22 46 15 3396 372.59 4.51 0.997 1.091 135.2964469

P00450 Ceruloplasmin 21.50235 17 44 17 1065 122.128 5.72 0.919 0.948 130.0607264

P69892 Hemoglobin subunit gamma-2 88.43537 12 64 1 147 16.116 7.2 2.018 1.305 196.0103188

A0A2R8Y7 Uncharacterized protein 86.90476 12 64 1 168 18.409 6.96 1.303 1.075 200.0579996

P02746 Complement C1q 41.50198 7 51 7 253 26.704 8.63 1.21 0.995 182.5711771

subcomponent subunit B

Q07954 Prolow-density lipoprotein 8.362676 28 36 28 4544 504.276 5.39 0.937 1.01 114.1164

receptor-related protein 1 H0Y4H1 Receptor-type tyrosine-protein 18.43532 15 30 2 1291 145.573 6.52 0.834 0.92 123.3979156

phosphatase F (Fragment)

Q03591 Complement factor H-related 37.57576 11 50 2 330 37.626 7.39 0.874 0.831 138.4850583

protein 1

P01019 Angiotensinogen 24.94845 9 29 9 485 53.121 6.32 0.761 1.051 112.7987204

O94769 Extracellular matrix protein 2 30.90129 16 33 16 699 79.739 5.41 0.966 1.029 110.4218652

H0YJV3 Nidogen-2 (Fragment) 31.52174 19 39 1 644 71.91 5.96 0.883 0.913 121.9617467

P07357 Complement component C8 26.71233 12 30 12 584 65.121 6.47 0.937 1.086 105.3026876

alpha chain

P08253 72 kDa type IV collagenase 35.90909 17 37 17 660 73.835 5.47 0.993 1.165 122.2369142

C9JF17 Apolipoprotein D (Fragment) 33.48837 8 77 8 215 24.142 5.6 0.763 0.833 243.5303714

P11021 Endoplasmic reticulum 36.08563 19 33 17 654 72.288 5.16 1.025 0.919 106.6952672

chaperone BiP

P07225 Vitamin K-dependent protein 33.43195 19 41 19 676 75.074 5.67 0.891 0.909 118.3490465

Q24JP5 Transmembrane protein 132A 19.35484 15 31 15 1023 110.041 5.62 0.982 0.927 112.8510547

O14786 Neuropilin-1 17.11809 12 32 12 923 103.069 5.88 1.014 0.994 104.9905369

A0A0C4DH Immunoglobulin heavy 52.99145 5 47 3 117 12.666 8.27 0.897 0.919 172.7532403 38 variable 5-51

Q9NRN5 Olfactomedin-like protein 3 32.75862 12 39 12 406 45.981 6.57 0.872 1.018 121.5150524

P01772 Immunoglobulin heavy 37.60684 4 74 1 117 13.065 8.94 1.014 0.738 179.8079971

variable 3-33

P05060 Secretogranin-1 18.75923 12 42 12 677 78.229 5.07 0.43 0.653 122.1391906

Q8N2S1 Latent-transforming growth 13.30049 16 29 16 1624 173.32 5.43 0.883 0.989 91.29506969

factor beta-binding protein 4

P05452 Tetranectin 49.50495 10 37 10 202 22.522 5.67 1.025 0.956 115.6876658

Q8WXD2 Secretogranin-3 40.81197 18 35 18 468 52.973 5.03 0.818 0.996 104.849102

O94856 Neurofascin 13.21455 18 27 18 1347 149.933 6.65 0.874 1.019 85.02410936

P05546 Heparin cofactor 2 28.65731 13 38 13 499 57.034 6.9 0.703 0.857 89.73312998

P20774 Mimecan 42.28188 11 25 11 298 33.901 5.63 0.859 0.951 95.63103676

C9JU00 Fibrinogen gamma chain 76.42276 9 43 1 123 13.979 7.2 1.475 1.562 121.569379

(Fragment)

P08670 Vimentin 33.04721 14 28 14 466 53.619 5.12 0.929 0.642 86.31107831

A0A0C4DH Immunoglobulin heavy 42.73504 4 52 2 117 12.812 8.84 1.252 1.053 124.0538703

31 variable 1-18

P05067 Amyloid-beta A4 protein 18.05195 11 29 10 770 86.888 4.82 1.274 1.362 107.6358273 O95967 EGF-containing fibulin-like 41.08352 13 24 13 443 49.372 4.94 0.935 1.006 64.79450321

extracellular matrix protein 2

Q92520 Protein FAM3C 46.25551 8 26 8 227 24.665 8.29 0.811 0.951 80.54141569

A0A2R8Y3 Uncharacterized protein 22.50396 11 23 11 631 71.278 7.66 0.855 0.896 69.02508879

P0DP03 Immunoglobulin heavy 37.60684 4 55 1 117 12.938 8.92 0.933 1.001 144.6797851

variable 3-30-5

P41222 Prostaglandin-H2 D- 24.73684 4 36 4 190 21.015 7.8 0.792 0.989 129.7730234

isomerase

A0A087WT Transthyretin 45.40541 8 23 8 185 20.133 5.33 0.903 0.939 91.19251633

P02741 C-reactive protein 27.67857 7 39 7 224 25.023 5.63 1.235 1.217 117.7326272

F6SYF8 Dickkopf-related protein 3 30.21978 8 24 8 364 39.924 4.7 0.809 1.013 89.94954038

P18428 Lipopolysaccharide-binding 20.58212 8 14 8 481 53.35 6.7 1.367 1.452 58.35807347

protein

P02538 Keratin, type II cytoskeletal 21.63121 12 32 3 564 60.008 8 0.675 0.765 92.53173935

A0A2Q2TT Immunoglobulin kappa 31.48148 2 61 2 108 11.835 5.34 1.073 1.002 256.4529862

Z9 variable 1-33 P01780 Immunoglobulin heavy 32.47863 4 76 2 117 12.934 6.57 1.321 1.115 193.2849478

variable 3-7

A0A0C4DH Immunoglobulin heavy 44.0678 4 44 2 118 13.058 9.29 1.249 0.913 121.7412282

41 variable 4-61

C9JV77 Alpha-2-HS-glycoprotein 26.08696 8 22 8 368 39.387 5.72 0.701 0.788 76.79577923

P10645 Chromogranin-A 33.69803 10 21 10 457 50.658 4.6 0.827 0.958 77.65168238

P13647 Keratin, type II cytoskeletal 5 22.37288 13 28 5 590 62.34 7.74 0.805 0.837 79.18268931

P69905 Hemoglobin subunit alpha 50.70423 5 36 5 142 15.248 8.68 0.564 0.629 121.9940966

P01762 Immunoglobulin heavy 53.84615 4 58 2 117 12.9 8.6 1.291 0.986 139.7722524

variable 3-11

P02747 Complement C1q 21.22449 4 31 4 245 25.757 8.41 1.219 0.946 112.9564657

subcomponent subunit C

J3KQ66 Reelin 5.549133 17 30 17 3460 388.185 5.88 0.854 0.918 79.16257274

P01782 Immunoglobulin heavy 34.74576 3 38 2 118 12.936 7.08 1.133 1.13 115.5749073

variable 3-9

P08294 Extracellular superoxide 37.08333 7 24 7 240 25.835 6.61 1.047 1.057 87.15283918

dismutase [Cu-Zn]

P10451 Osteopontin 13.3758 3 34 3 314 35.401 4.58 1.338 0.99 127.6464496 P62736 Actin, aortic smooth muscle 22.01592 7 27 1 377 41.982 5.39 1.118 0.903 82.49907935

Q9NQ79 Cartilage acidic protein 1 21.18003 11 18 11 661 71.376 5.12 0.982 0.97 63.47049093

A0A0J9YY Uncharacterized protein 32.47863 4 55 1 117 12.956 8.92 0.832 0.864 130.4343187

99 (Fragment)

P01763 Immunoglobulin heavy 35.04274 3 57 1 117 12.804 5.36 1.286 0.978 138.5215894

variable 3-48

A0A0B4J1 Immunoglobulin heavy 53.84615 4 59 2 117 12.831 8.28 0.949 0.942 138.7624124

V1 variable 3-21

Q9HCB6 Spondin-1 20.69393 12 22 12 807 90.914 6.11 0.899 1.061 62.4842453

P01767 Immunoglobulin heavy 37.06897 3 53 1 116 12.761 8.28 1.152 0.953 139.5994531

variable 3-53

A0A0B4J1 Immunoglobulin heavy 37.60684 4 60 1 117 12.831 8.66 1.038 0.952 146.8222654

X5 variable 3-74

Q9UHG2 ProSAAS 25.56571 5 29 5 260 27.356 6.62 0.797 0.936 105.5507272

O15240 Neurosecretory protein VGF 18.53659 9 24 9 615 67.218 4.78 0.822 1.05 88.6339159

P08572 Collagen alpha-2(IV) chain 6.308411 8 19 8 1712 167.449 8.66 0.905 0.968 60.76025867

S4R460 Immunoglobulin heavy 60.41667 4 61 3 96 10.423 7.97 1.124 0.981 260.4735351

variable 3/OR16-9 (non-

functional) O75882 Attractin 8.887334 12 21 12 1429 158.432 7.31 0.899 0.914 57.12443745

Q9Y240 C-type lectin domain family 28.48297 8 19 8 323 35.673 5.16 0.869 1.03 57.50902295

11 member A

A0A0C4DH Immunoglobulin heavy 28.20513 3 54 1 117 12.999 9.55 0.892 0.945 115.8692799

29 variable 1-3

Q8IUX7 Adipocyte enhancer-binding 13.73057 13 21 13 1158 130.847 5.11 0.986 1.093 75.11807919

protein 1

P13521 Secretogranin-2 20.90762 10 19 10 617 70.897 4.75 0.853 0.951 59.23979521

Q99715 Collagen alpha-1(XII) chain 7.084558 17 20 17 3063 332.941 5.53 0.933 1.02 52.9705224

A0A075B7 Immunoglobulin heavy 18.80342 2 35 1 117 12.866 6.51 1.092 0.967 94.6948216

B8 variable 3/OR16-12 (non-

functional) (Fragment)

P21246 Pleiotrophin 45.83333 7 28 7 168 18.93 9.6 0.915 1.51 83.90634847

P23083 Immunoglobulin heavy 26.49573 3 47 1 117 13.076 9.13 0.887 0.555 103.3184353

variable 1-2

P08571 Monocyte differentiation 31.46667 10 19 10 375 40.051 6.23 1.168 1.009 74.44608319

antigen CD14

Q9Y279 V-set and immunoglobulin 28.82206 8 21 8 399 43.959 6.35 0.638 0.655 61.2986939

domain-containing protein 4 P01011 Alpha-1-antichymotrypsin 23.40426 8 18 8 423 47.621 5.52 0.809 0.809 65.44287133

Q16706 Alpha-mannosidase 2 15.47203 16 25 15 1144 131.057 7.58 0.954 0.986 63.75339913

P22897 Macrophage mannose receptor 12.63736 15 21 15 1456 165.905 6.54 0.924 0.894 50.71406555

P01743 Immunoglobulin heavy 28.20513 3 54 1 117 12.924 8.92 1.187 1.064 118.9093745

variable 1-46

K7ER74 APOC4-APOC2 readthrough 28.08989 4 21 4 178 20.036 6.64 1.131 1.145 75.01176333

(NMD candidate)

P01742 Immunoglobulin heavy 45.29915 5 47 2 117 12.651 9.17 1.035 0.59 92.87927413

variable 1-69

P02749 Beta-2-glycoprotein 1 35.07246 9 18 9 345 38.273 7.97 0.921 0.927 62.79069901

P04433 Immunoglobulin kappa 58.26087 4 28 3 115 12.567 4.96 1.32 1.053 72.31677985

variable 3-11

P01619 Immunoglobulin kappa 46.55172 4 27 3 116 12.549 4.96 1.191 1.144 91.41928077

variable 3-20

P36980 Complement factor H-related 37.03704 8 21 3 270 30.631 6.38 0.839 0.929 63.78572786

protein 2

B0YIW2 Apolipoprotein C-III variant 1 29.05983 4 28 4 117 12.807 8.18 0.955 1.282 96.72932458

P01042 Kininogen-1 18.1677 10 20 10 644 71.912 6.81 0.981 1.036 55.0574398 P01764 Immunoglobulin heavy 37.60684 3 33 1 117 12.574 8.28 1.101 1.113 98.1920439

variable 3-23

P07360 Complement component C8 58.91089 7 19 7 202 22.264 8.31 0.965 1.173 58.55921876

gamma chain

P0DP01 Immunoglobulin heavy 49.57265 4 53 2 117 12.983 9.17 1.124 0.98 109.7483518

variable 1-8

Q9P232 Contactin-3 17.2179 14 19 14 1028 112.812 6.3 0.96 0.941 43.75985217

D6RF35 Vitamin D-binding protein 27.10084 13 17 13 476 52.986 5.52 1.089 1.037 49.2026974

Q9UHC6 Contactin-associated protein- 11.79564 12 17 12 1331 148.073 6.58 0.909 0.966 45.66921902

like 2

A0A0B4J2 Immunoglobulin heavy 45.29915 4 45 1 117 12.652 8.47 1.056 0.984 88.69126487

H0 variable 1-69D

P06312 Immunoglobulin kappa 34.71074 4 46 4 121 13.372 5.25 1.287 0.952 111.6955808

variable 4-1

A0A0C4DH Immunoglobulin kappa 29.05983 2 46 1 117 12.637 8.31 1.233 0.887 159.1169224

73 variable 1-12

O00468 Agrin 7.063377 11 15 11 2067 217.092 6.39 0.95 1.04 41.38957059

P43146 Netrin receptor DCC 9.67519 11 18 11 1447 158.357 6.77 1.002 1.008 44.79053068

P55268 Laminin subunit beta-2 10.06674 12 15 12 1798 195.854 6.52 0.903 1.014 46.111992 G3V4U0 Fibulin-5 16.77704 7 23 7 453 50.847 4.77 0.893 0.987 65.45300519

P68871 Hemoglobin subunit beta 68.02721 8 29 7 147 15.988 7.28 0.583 0.667 84.50491452

P02760 Protein AMBP 18.46591 6 16 6 352 38.974 6.25 1.146 1.027 51.55372882

P02763 Alpha-1-acid glycoprotein 1 34.82587 6 12 4 201 23.497 5.02 0.881 1.015 40.89200163

P00488 Coagulation factor XIII A 16.53005 9 18 9 732 83.215 6.09 1.257 0.827 53.4234997

chain

F8W703 Roundabout homolog 2 10.28492 11 16 9 1439 157.257 6.3 0.934 0.956 40.79797089

Q8IWV2 Contactin-4 10.42885 8 13 7 1026 113.383 7.47 0.937 0.986 45.05356431

A0A0C4DH Immunoglobulin kappa 29.05983 2 24 1 117 12.706 8.29 1.36 0.957 102.5505395

69 variable 1-9

D6RGZ6 Versican core protein 6.935484 8 17 1 1240 135.661 4.5 0.972 1.132 56.69772339

(Fragment)

O95428 Papilin 9.546166 8 9 8 1278 137.612 6.89 0.997 0.991 30.32127047

P31146 Coronin-1A 23.42733 9 11 9 461 50.994 6.68 1.263 0.857 37.99821258

P04406 Glyceraldehyde-3-phosphate 34.92537 9 17 9 335 36.03 8.46 0.972 0.853 44.43898368

dehydrogenase

A0A0D9SF Neurexin-1-beta (Fragment) 38.49765 7 20 1 213 23.008 6.32 0.885 1.102 59.34383881

36 P02792 Ferritin light chain 28.57143 4 18 4 175 20.007 5.78 2.368 0.966 47.40906429

A1L4H1 Soluble scavenger receptor 10.36236 9 13 9 1573 165.639 6.13 0.961 1.01 46.33395004

cysteine-rich domain-

containing protein SSC5D

A0A0B4J1 Immunoglobulin heavy 34.74576 3 26 2 118 13.068 5.41 1.211 0.919 55.60068369

X8 variable 3-43

P10412 Histone H1.4 28.76712 8 17 3 219 21.852 11.03 0.809 0.903 51.11493194

Q6UX71 Plexin domain-containing 21.73913 9 22 9 529 59.546 6.46 0.917 0.975 61.43700206

protein 2

P01008 Antithrombin-III 18.31897 8 11 8 464 52.569 6.71 0.979 1.047 31.82683587

P62805 Histone H4 51.45631 6 18 6 103 11.36 11.36 1.417 0.721 42.72476315

A0A087X0 Immunoglobulin kappa 50 3 19 3 104 11.427 4.49 1.441 0.967 67.15511155

Q4 variable 2-40

A0A087W Neural cell adhesion molecule 11.99095 9 11 9 884 97.253 4.93 0.849 0.835 31.29230547

V75 1

P02462 Collagen alpha-1(IV) chain 3.475135 4 13 4 1669 160.51 8.28 0.986 0.938 51.50371313

P14625 Endoplasmin 17.68369 11 14 10 803 92.411 4.84 1 0.852 38.30185843

A0A087W Clathrin heavy chain 7.385348 10 13 10 1679 191.936 5.69 1.138 0.919 35.45963311

VQ6 Q8N3T6 Transmembrane protein 132C 9.747292 8 11 8 1108 121.711 6.35 0.948 0.868 37.4195888

P04432 Immunoglobulin kappa 29.05983 2 41 1 117 12.729 8.66 1.135 0.994 142.0995042

variable 1D-39

P24821 Tenascin 7.042254 10 12 10 2201 240.7 4.89 0.941 1.014 33.59456897

P18065 Insulin-like growth factor- 29.53846 7 18 7 325 34.791 7.5 1.032 1.029 50.39183426

binding protein 2

A0A0B4J1 Immunoglobulin heavy 35.29412 4 23 2 119 13.194 7.85 1.166 0.962 44.69129026

Y9 variable 3-72

A0A075B6 Immunoglobulin kappa 29.05983 2 23 1 117 12.703 8.29 1.59 1.094 99.54478717

S5 variable 1-27

A0A0J9YX Immunoglobulin heavy 26.49573 3 17 1 117 12.764 8.28 0.229 0.213 53.36616898

X1 variable 5-10-1

Q14393 Growth arrest-specific protein 8.460472 5 12 5 721 79.625 6.21 0.951 0.942 37.37333357

P07195 L-lactate dehydrogenase B 28.14371 8 10 7 334 36.615 6.05 0.816 0.947 34.73956013

chain

P02654 Apolipoprotein C-I 32.53012 4 26 4 83 9.326 8.47 1.294 1.453 72.02493954

Q9UBG0 C-type mannose receptor 2 8.789723 9 10 9 1479 166.568 5.83 0.888 0.93 32.04108715

P02748 Complement component C9 9.838998 5 13 5 559 63.133 5.59 1.148 1.166 41.01697934 P06702 Protein S100-A9 55.26316 5 16 5 114 13.234 6.13 0.512 0.478 46.12688518

P05155 Plasma protease C1 inhibitor 14 6 11 6 500 55.119 6.55 0.954 0.992 36.49998665

P07900 Heat shock protein HSP 90- 13.11475 9 15 3 732 84.607 5.02 1.523 0.912 44.34405565

alpha

Q93063 Exostosin-2 16.85237 8 10 8 718 82.202 6.55 1.038 0.972 34.17820978

P02790 Hemopexin 17.74892 5 8 5 462 51.643 7.02 0.997 1.097 26.19407308

Q99784 Noelin 14.43299 7 12 7 485 55.307 6.95 0.841 1.016 24.06632328

P06276 Cholinesterase 13.62126 7 11 7 602 68.374 7.42 0.787 1.078 31.51544464

A0A087W Collagen alpha-1(V) chain 4.733406 8 11 7 1838 183.54 5.07 0.791 0.872 32.53059745

XW9

P01766 Immunoglobulin heavy 18.96552 2 22 1 116 12.498 7.08 1.074 1.113 49.43738508

variable 3-13

P01817 Immunoglobulin heavy 12.60504 1 8 1 119 13.223 8.29 1.775 1.926 21.83701611

variable 2-5

A0A0C4DH Immunoglobulin kappa 21.55172 2 20 1 116 12.507 4.59 1.16 1.055 71.67139959

25 variable 3D-20

Q9UBQ6 Exostosin-like 2 19.39394 5 12 5 330 37.441 8.95 0.93 0.926 35.94186735

P68363 Tubulin alpha-1B chain 19.06874 6 9 1 451 50.12 5.06 1.103 0.856 32.49740529 P12110 Collagen alpha-2(VI) chain 8.439647 7 10 7 1019 108.512 6.21 0.925 0.902 28.05413151

P19022 Cadherin-2 5.629139 4 17 4 906 99.747 4.81 0.888 1.017 50.97761357

P00742 Coagulation factor X 17.0082 7 11 7 488 54.697 5.94 0.831 0.749 28.57849181

A0A0A0M Immunoglobulin heavy 42.01681 4 15 4 119 13.048 8.62 0.85 1.013 38.34672987

S15 variable 3-49

P23471 Receptor-type tyrosine-protein 3.36933 7 9 7 2315 254.429 4.88 0.777 1.052 28.14834929

phosphatase zeta

A0A096LP SAA2-SAA4 readthrough 24.51923 5 13 3 208 23.338 8.98 0.879 1.214 38.32234967

O60462 Neuropilin-2 9.129968 6 11 6 931 104.764 5.17 0.916 0.927 28.50492644

Q71U36 Tubulin alpha-1A chain 19.06874 6 8 1 451 50.104 5.06 1.173 0.963 29.61507583

P17900 Ganglioside GM2 activator 40.93264 5 10 5 193 20.825 5.31 0.767 0.949 33.73345375

Q8TER0 Sushi, nidogen and EGF-like 6.51097 8 9 8 1413 152.104 6.98 1.076 1.02 26.38287878

domain-containing protein 1

P07437 Tubulin beta chain 19.59459 6 7 6 444 49.639 4.89 1.091 0.862 24.50897264

A0A0A0M Laminin subunit alpha-4 5.924301 8 11 8 1823 202.441 6.25 0.872 0.894 26.423329

QS9

C9JFF1 Seizure protein 6 homolog 6.740443 5 10 5 994 107.306 5.3 0.895 0.92 23.98485804 A0A075B7 Immunoglobulin heavy 24.78632 3 22 1 117 12.895 8.31 0.99 0.782 50.11345041

E8 variable 3/OR16-13 (non-

functional) (Fragment)

Q6UVK1 Chondroitin sulfate 4.349699 7 9 7 2322 250.382 5.47 1.012 0.991 27.26497269

proteoglycan 4

Q92911 Sodium/iodide cotransporter 9.797823 5 10 5 643 68.622 7.39 0.966 1.07 31.02088892

P35579 Myosin-9 4.540816 6 6 6 1960 226.392 5.6 1.235 0.901 18.66729665

P02533 Keratin, type I cytoskeletal 14 15.25424 7 15 4 472 51.529 5.16 0.834 0.869 34.57605505

P16035 Metalloproteinase inhibitor 2 25 5 10 5 220 24.383 7.49 0.916 1.062 23.2566241

P08238 Heat shock protein HSP 90- 11.87845 8 13 1 724 83.212 5.03 1.428 0.77 37.95699954

beta

P48740 Mannan-binding lectin serine 9.871245 5 10 4 699 79.195 5.49 1.132 1.116 31.27463913

protease 1

U3KQK0 Histone H2B 24.6988 4 11 4 166 18.792 10.54 1.447 0.669 29.86686897

P12107 Collagen alpha-1(XI) chain 4.318937 6 7 5 1806 180.954 5.17 0.98 0.985 15.25267124

P39060 Collagen alpha-1(XVIII) 4.389966 5 6 5 1754 178.077 6.01 0.87 0.969 23.83395267

chain

P35442 Thrombospondin-2 7.167235 5 6 5 1172 129.908 4.83 1.055 1.09 18.2932415 P19320 Vascular cell adhesion protein 11.77267 8 8 8 739 81.224 5.22 0.865 0.774 21.89148533

P00338 L-lactate dehydrogenase A 24.39759 8 13 7 332 36.665 8.27 0.799 0.91 36.05286312

chain

P34931 Heat shock 70 kDa protein 1- 9.672387 4 8 2 641 70.331 6.02 1.15 0.84 25.13015938

Q96CX2 BTB/POZ domain-containing 21.53846 5 8 5 325 35.679 5.64 0.967 0.878 25.82741261

protein KCTD12

O00391 Sulfhydryl oxidase 1 8.567604 5 5 5 747 82.526 8.92 1.025 0.971 18.91742945

Q9NY15 Stabilin-1 4.241245 7 8 7 2570 275.3 6.49 1.003 0.948 23.4669404

P80748 Immunoglobulin lambda 23.07692 2 8 2 117 12.438 5.29 1.195 0.989 29.86564922

variable 3-21

P01599 Immunoglobulin kappa 23.07692 2 5 2 117 12.77 8.68 1.046 0.976 18.68417668

variable 1-17

P01700 Immunoglobulin lambda 24.78632 2 13 1 117 12.276 5.91 0.98 0.892 47.09251714

variable 1-47

Q16394 Exostosin-1 11.12601 7 8 7 746 86.2 9.04 0.956 0.997 23.26652241

P49641 Alpha-mannosidase 2x 7.043478 7 8 6 1150 130.457 6.84 1 1.024 17.46408725

A0A087WS Immunoglobulin kappa 32.17391 3 9 2 115 12.526 5.19 0.981 1.148 26.248317 Y6 variable 3D-15

Q14515 SPARC-like protein 1 7.981928 4 8 4 664 75.161 4.81 0.83 0.94 29.65173864

Q8WY21 VPS10 domain-containing 8.818493 8 11 8 1168 129.553 7.58 0.852 0.872 27.93523681

receptor SorCS1

Q05707 Collagen alpha-1(XIV) chain 4.732739 6 7 6 1796 193.394 5.3 0.949 1.007 19.0616405

Q9Y490 Talin-1 3.227076 4 4 4 2541 269.599 6.07 1.379 0.96 13.91558695

Q5BLP8 Neuropeptide-like protein 30.52632 4 19 4 95 10.163 8.31 0.909 0.853 60.85209751

C4orf48

P54764 Ephrin type-A receptor 4 7.302231 5 7 5 986 109.79 6.61 0.95 0.939 23.69675064

P27169 Serum 16.90141 5 8 5 355 39.706 5.22 0.958 1.019 20.67413521

paraoxonase/arylesterase 1

A0A0C4DH Immunoglobulin heavy 16.23932 2 10 2 117 12.802 7.88 1.222 1.008 24.93146586

35 variable 3-35 (non-functional)

(Fragment)

A0A075B6 Immunoglobulin lambda 34.78261 4 12 3 115 12.433 4.83 0.996 0.949 32.95777202

K4 variable 3-10

P68104 Elongation factor 1-alpha 1 19.48052 6 8 6 462 50.109 9.01 1.088 0.807 21.43942118

P35052 Glypican-1 13.62007 5 7 5 558 61.641 7.3 0.893 1.094 19.84249425 Q15904 V-type proton ATPase subunit 9.148936 3 4 3 470 51.993 6.14 0.791 0.867 15.82723546

Q9UHG3 Prenylcysteine oxidase 1 11.88119 5 7 5 505 56.604 6.18 0.96 0.994 22.73323512

A0A075B6 Immunoglobulin kappa 42.24138 3 24 3 116 12.775 5.25 1.287 1.112 53.83410645

H7 variable 3-7 (non-functional)

(Fragment)

P19021 Peptidyl-glycine alpha- 7.29702 7 10 7 973 108.263 6.42 0.78 0.94 22.97336459

amidating monooxygenase

P07585 Decorin 12.81337 5 7 4 359 39.722 8.54 0.845 1.079 21.93158746

P16403 Histone H1.2 25.35211 6 12 1 213 21.352 10.93 1.115 0.947 30.95647776

O15031 Plexin-B2 3.862894 4 5 4 1838 204.997 6.24 1.05 1.091 19.73093224

P19652 Alpha-1-acid glycoprotein 2 21.89055 4 6 2 201 23.588 5.11 0.952 1.3 14.83352566

A0A0J9YX Immunoglobulin heavy 18.80342 2 15 2 117 12.814 7.85 1.073 0.986 26.27050018

35 variable 3-64D

Q06033 Inter-alpha-trypsin inhibitor 7.640449 5 5 5 890 99.787 5.74 1.283 0.962 17.40087748

heavy chain H3

J3KPS3 Fructose-bisphosphate 16.84783 5 8 5 368 39.793 8.09 1.106 1.015 30.15881014

aldolase

P27918 Properdin 13.64606 4 4 4 469 51.242 7.9 1.045 0.988 15.927742 A0A075B6 Immunoglobulin kappa 16.66667 2 8 2 120 13.071 8.87 1.373 0.993 24.2537272

R9 variable 2D-24 (non-

functional) (Fragment)

E9PQD6 Serum amyloid A protein 35.2459 3 3 1 122 13.538 6.79 1.324 1.252 13.35751843

Q9UM47 Neurogenic locus notch 3.231366 6 6 6 2321 243.468 5.39 0.967 0.93 15.32052732

homolog protein 3

P04003 C4b-binding protein alpha 9.547739 4 6 4 597 66.989 7.3 0.903 0.993 17.82205987

chain

P54289 Voltage-dependent calcium 6.799637 5 5 5 1103 124.49 5.27 0.892 0.894 15.23961294

channel subunit alpha-2/delta-

Q7Z553 MAM domain-containing 6.903766 4 5 4 956 107.368 7.2 1.015 1.019 17.6841054

glycosylphosphatidylinositol

anchor protein 2

P20396 Pro-thyrotropin-releasing 15.28926 2 3 2 242 27.388 5.45 1.096 1.179 14.52716875

hormone

P35556 Fibrillin-2 1.442308 3 6 1 2912 314.558 4.86 1.011 1.009 19.70407271

Q92954 Proteoglycan 4 4.77208 5 5 5 1404 150.968 9.51 0.985 1.011 17.02740145

P31151 Protein S100-A7 33.66337 3 6 3 101 11.464 6.77 0.486 0.466 19.76926899 C9J2H1 Inter-alpha-trypsin inhibitor 7.430998 6 8 6 942 104.48 8.38 0.94 1.096 21.54647255

heavy chain H5

Q6YHK3 CD109 antigen 4.221453 5 5 5 1445 161.587 5.85 0.967 0.928 15.17792416

P35443 Thrombospondin-4 5.931322 4 6 4 961 105.802 4.68 1.106 1.005 18.13027453

A0A0U1RR Histone H2A 20.58824 3 6 3 170 18.541 11.52 1.563 0.572 25.5635848

P01344 Insulin-like growth factor II 13.88889 2 4 2 180 20.127 9.32 0.998 1.051 12.35072207

P01699 Immunoglobulin lambda 38.46154 2 7 1 117 12.194 5.17 0.816 0.812 18.83399343

variable 1-44

P11717 Cation-independent mannose- 2.609394 5 5 5 2491 274.199 5.94 0.942 0.949 10.1462822

6-phosphate receptor

P04430 Immunoglobulin kappa 29.05983 2 4 2 117 12.61 8.16 1.405 1.033 16.53339887

variable 1-16

A0A286YE Immunoglobulin heavy 16.83417 5 6 5 398 42.821 5.64 1.075 1.551 19.30940413

Y1 constant alpha 1 (Fragment)

H0YAC1 Plasma kallikrein (Fragment) 7.87172 5 6 5 686 76.833 8.06 0.966 1.057 16.15340185

P01714 Immunoglobulin lambda 34.82143 2 6 2 112 12.035 4.96 1.182 0.947 17.55187321

variable 3-19

P01814 Immunoglobulin heavy 36.13445 2 3 1 119 13.252 6.52 1.179 1.199 9.413112879 variable 2-70

A0A0C4DH Immunoglobulin heavy 40.17094 3 17 2 117 12.816 5.16 1.14 0.797 43.22818255

33 variable 1-24

A0A0J9YW Uncharacterized protein 43.10345 4 20 1 116 12.935 9.06 1.031 0.915 46.2571696

U9 (Fragment)

A0A0C4DH Immunoglobulin heavy 44.44444 4 15 2 117 13.116 9.29 1.582 1.11 32.19099617

34 variable 4-28

O95897 Noelin-2 14.53744 5 5 5 454 51.353 7.94 0.975 1.029 14.72313333

P01210 Proenkephalin-A 16.4794 3 4 3 267 30.767 5.53 0.99 1.125 14.29998636

P04211 Immunoglobulin lambda 15.38462 2 7 1 117 12.443 7.03 1.996 1.029 19.63640356

variable 7-43

P55285 Cadherin-6 6.202532 3 4 3 790 88.254 4.93 0.863 0.989 11.77362657

E7EX29 14-3-3 protein zeta/delta 15.04065 3 3 1 246 28.019 4.92 1.008 0.798 10.30245829

(Fragment)

O95445 Apolipoprotein M 32.44681 6 11 6 188 21.239 6.01 1.09 1.07 25.74370086

P51884 Lumican 12.42604 3 6 3 338 38.405 6.61 1.015 0.967 18.2634325

O94772 Lymphocyte antigen 6H 22.14286 3 6 3 140 14.659 7.25 0.719 0.797 14.21915698

P62258 14-3-3 protein epsilon 14.5098 3 3 1 255 29.155 4.74 1.31 0.944 10.48452115 P05160 Coagulation factor XIII B 4.387292 2 4 2 661 75.461 6.39 1.052 1.127 10.27187848

chain

P04196 Histidine-rich glycoprotein 10.28571 5 6 5 525 59.541 7.5 0.944 1.049 14.24334323

A0A0B4J1 Immunoglobulin heavy 31.09244 3 7 2 119 12.917 8.62 0.978 1.079 20.13617635

V0 variable 3-15

C9J650 Neuroendocrine protein 7B2 8.80829 1 2 1 193 21.372 4.94 0.984 1.041 7.817018032

A0A0C4DH Immunoglobulin heavy 24.36975 2 6 1 119 13.304 8.29 0.171 0.163 17.26096582

43 variable 2-70D

O75326 Semaphorin-7A 8.408408 4 6 4 666 74.776 7.64 0.983 1.004 15.12375474

Q01518 Adenylyl cyclase-associated 9.473684 4 6 4 475 51.869 8.06 1.124 0.835 14.48113203

protein 1

P62979 Ubiquitin-40S ribosomal 25.64103 4 6 4 156 17.953 9.64 0.843 0.858 17.81768918

protein S27a

A0A087WS Immunoglobulin kappa 16.23932 1 2 1 117 12.828 7.74 1.146 0.902 9.84670496

Z0 variable 1D-8

Q9BUN1 Protein MENT 8.797654 2 5 2 341 36.746 8.59 1 0.975 15.9503541

P01701 Immunoglobulin lambda 38.46154 3 9 3 117 12.241 7.03 0.874 0.757 19.60087895

variable 1-51

Q16849 Receptor-type tyrosine-protein 3.064351 2 3 2 979 105.781 7.11 0.762 0.96 10.44954824 phosphatase-like N

P05997 Collagen alpha-2(V) chain 2.468312 4 7 3 1499 144.821 6.46 0.86 0.902 8.483214617

P55290 Cadherin-13 6.030856 4 5 4 713 78.238 4.98 0.903 0.98 16.89196992

P61278 Somatostatin 16.37931 2 9 2 116 12.727 5.52 0.689 0.934 27.66441822

A0A0B4J1 Immunoglobulin lambda 16.26016 2 4 2 123 13.016 7.28 0.566 0.383 11.32931447

Y8 variable 9-49

Q06481 Amyloid-like protein 2 3.145478 2 3 1 763 86.9 4.79 0.479 0.771 8.72531271

P01717 Immunoglobulin lambda 18.75 2 18 1 112 12.004 4.5 0.87 0.727 53.72631598

variable 3-25

O75787 Renin receptor 11.14286 3 4 3 350 38.983 6.1 0.91 1.021 9.984716415

Q9BYH1 Seizure 6-like protein 4.394531 3 4 3 1024 111.711 4.78 0.81 0.883 11.3955934

A0A0G2JR Uncharacterized protein 13.67521 2 18 2 117 12.74 8.29 2.585 1.107 37.33334506

Q6 (Fragment)

A0A075B7 Immunoglobulin heavy 20.16807 2 10 1 119 13.072 8.28 1.077 0.982 10.365031

D8 variable 3/OR15-7

(pseudogene) (Fragment)

P16401 Histone H1.5 14.60177 4 6 1 226 22.566 10.92 0.932 0.808 16.3841151

P11142 Heat shock cognate 71 kDa 5.727554 3 6 1 646 70.854 5.52 1.256 0.977 16.45200515 protein

Q16270 Insulin-like growth factor- 13.47518 3 4 3 282 29.111 7.9 0.954 0.983 12.99817467

binding protein 7

Q9UQM7 Calcium/calmodulin- 5.230126 1 2 1 478 54.054 7.08 0.761 0.885 9.663061619

dependent protein kinase type

II subunit alpha

P01721 Immunoglobulin lambda 17.09402 1 2 1 117 12.558 4.78 0.904 0.946 9.127590895

variable 6-57

P08758 Annexin A5 9.6875 2 2 2 320 35.914 5.05 0.724 0.702 7.304258108

P49747 Cartilage oligomeric matrix 7.793923 3 3 3 757 82.808 4.6 1.059 0.995 8.271230936

protein

P31150 Rab GDP dissociation 11.85682 3 3 3 447 50.55 5.14 0.88 1 9.760405302

inhibitor alpha

P47972 Neuronal pentraxin-2 7.192575 2 2 2 431 47.012 5.63 0.897 0.95 7.778153181

P02743 Serum amyloid P-component 22.86996 5 8 5 223 25.371 6.54 0.775 0.851 18.65017509

Q9H2X0 Chordin 4.08377 3 4 3 955 101.966 7.75 0.882 0.892 13.47952604

Q13867 Bleomycin hydrolase 10.98901 5 6 5 455 52.528 6.27 0.933 0.813 10.39226937

H3BLU2 Limbic system-associated 10.14493 3 4 3 345 37.991 6.86 1.047 1.029 10.86530876

membrane protein (Fragment) A0A075B7 Immunoglobulin heavy 27.35043 3 22 2 117 13.003 9.13 0.664 0.607 53.07422614

D0 variable 1/OR15-1 (non-

functional) (Fragment)

C9JIZ6 Prosaposin 6.83112 2 4 2 527 58.402 5.17 1.284 1.119 11.90637851

P15291 Beta-1,4-galactosyltransferase 9.798995 3 3 3 398 43.892 8.65 0.88 0.887 9.144854426

A0A075B6 Immunoglobulin heavy 18.64407 2 6 2 118 12.882 7.85 1.004 0.779 10.81513023

Q5 variable 3-64

P12318 Low affinity immunoglobulin 9.77918 2 2 2 317 34.978 6.68 1.123 1.03 9.205757618

gamma Fc region receptor II-a

A0A075B6I Immunoglobulin lambda 14.7541 2 6 2 122 12.806 4.55 0.694 0.599 18.62005115

0 variable 8-61

Q09328 Alpha-1,6- 4.183536 3 5 3 741 84.488 8.12 0.943 1.031 10.04575634

mannosylglycoprotein 6-beta-

N-

acetylglucosaminyltransferase

Q9UQ52 Contactin-6 3.599222 3 5 2 1028 113.885 6 0.929 1.015 9.098098516

O75711 Scrapie-responsive protein 1 35.71429 3 5 3 98 11.073 6.71 0.918 1.029 13.06385684 P07355 Annexin A2 8.849558 2 2 2 339 38.58 7.75 0.988 0.908 7.930880785

J3KN67 Tropomyosin alpha-3 chain 13.33333 4 5 4 285 33.202 4.77 1.148 0.846 11.92337799

Q5BIV9 Shadow of prion protein 16.55629 1 1 1 151 14.513 11.36 1.084 1.005 6.326342583

Q8NBI3 Draxin 7.163324 2 3 2 349 38.625 7.69 1.153 1.056 7.815519333

P33908 Mannosyl-oligosaccharide 4.74732 2 2 2 653 72.922 6.47 0.853 1.013 7.839189768

1,2-alpha-mannosidase IA

H7C4X7 Neuroendocrine protein 7B2 8.333333 1 2 1 216 24.039 6.52 0.807 1 7.56017375

(Fragment)

Q9UBX1 Cathepsin F 7.438017 3 3 3 484 53.332 8.22 1.014 0.903 8.492710114

P09486 SPARC 14.19142 3 3 3 303 34.61 4.84 0.972 0.961 8.674708843

Q14766 Latent-transforming growth 4.067403 5 5 5 1721 186.673 5.96 0.933 0.971 12.17760849

factor beta-binding protein 1

Q14118 Dystroglycan 4.134078 3 4 3 895 97.381 8.56 0.737 0.981 12.05706

Q9Y3Z3 Deoxynucleoside triphosphate 6.86901 3 3 3 626 72.155 7.14 1.362 0.965 5.907426596

triphosphohydrolase

SAMHD1

P28838 Cytosol aminopeptidase 5.39499 2 3 2 519 56.131 7.93 1.196 0.884 6.660748482

A6NMH8 Tetraspanin 7.29927 1 1 1 274 29.786 6.92 0.871 1.011 4.685519218 P58417 Neurexophilin-1 8.487085 2 4 2 271 31.063 8.63 1.043 1.074 11.91627312

A0A0B4J1 Immunoglobulin heavy 21.4876 3 19 3 121 13.473 9.2 1.874 0.956 32.06293344

U7 variable 6-1

P08697 Alpha-2-antiplasmin 6.720978 3 3 3 491 54.531 6.29 0.986 0.996 10.65950298

P11597 Cholesteryl ester transfer 5.679513 2 2 2 493 54.721 6.09 1.064 0.996 6.516685963

protein

Q02809 Procollagen-lysine,2- 3.713893 2 3 2 727 83.497 6.95 0.95 1.137 9.022554636

oxoglutarate 5-dioxygenase 1

A0A0B4J1 Immunoglobulin lambda 13.67521 1 4 1 117 12.47 4.78 0.903 0.623 13.01889586

U3 variable 1-36

A0A0B4J1 Immunoglobulin heavy 17.64706 2 7 2 119 13.174 8.29 0.869 1.305 6.610331297

V2 variable 2-26

A0A1X7SB Neuronal pentraxin receptor 4.6 2 4 2 500 52.795 6.21 0.694 0.803 11.35587358

Q9UJJ9 N-acetylglucosamine-1- 11.80328 2 2 2 305 33.952 6.95 0.849 0.951 7.18126893

phosphotransferase subunit

gamma

P05109 Protein S100-A8 31.1828 3 5 3 93 10.828 7.03 0.684 0.676 10.32500505

P01709 Immunoglobulin lambda 6.779661 1 6 1 118 12.374 5.91 0.919 0.943 15.79836607 variable 2-8

P15814 Immunoglobulin lambda-like 7.042254 1 2 1 213 22.949 10.07 0.849 0.798 7.219301462

polypeptide 1

Q9H4D0 Calsyntenin-2 4.816754 3 5 3 955 106.938 5.39 0.914 1.005 11.0102942

P02794 Ferritin heavy chain 14.20765 2 2 2 183 21.212 5.55 1.455 1.065 6.528439045

P08493 Matrix Gla protein 10.67961 1 3 1 103 12.345 9.67 1.011 0.895 11.13990211

P23435 Cerebellin-1 13.98964 3 5 3 193 21.084 7.28 0.908 1.17 12.48828781

Q12841 Follistatin-related protein 1 9.090909 3 4 3 308 34.963 5.52 0.901 1.124 9.8314147

O43505 Beta-1,4- 9.156627 3 3 3 415 47.089 7.2 1.042 0.969 7.68761158

glucuronyltransferase 1

A0A075B6I Immunoglobulin lambda 15.38462 2 6 1 117 12.46 7.2 1.26 0.799 17.20948243

9 variable 7-46

P78539 Sushi repeat-containing 7.327586 3 3 3 464 51.538 8.66 1.114 1.103 7.839477062

protein SRPX

Q9BXJ0 Complement C1q tumor 11.52263 2 3 2 243 25.283 6.54 1.007 0.989 9.406158209

necrosis factor-related protein

Q9Y6N6 Laminin subunit gamma-3 1.968254 2 3 2 1575 171.117 6.58 1.007 0.847 9.122236729 P61160 Actin-related protein 2 6.091371 2 2 2 394 44.732 6.74 1.21 0.899 6.874537468

Q86UD1 Out at first protein homolog 9.52381 2 2 2 273 30.669 6.84 0.833 0.961 4.756427765

F8W1S1 Keratin, type II cytoskeletal 74 5.156538 3 6 1 543 59.37 7.44 0.897 1.009 10.60759139

Q96NU0 Contactin-associated protein- 1.940994 2 2 2 1288 140.326 7.4 1.078 0.862 6.16936326

like 3B

A0A0A0M UPF0764 protein C16orf89 5.990783 2 3 2 434 48.788 5.99 0.9 0.969 8.104348183

T71

P04156 Major prion protein 4.743083 1 2 1 253 27.643 9 1.085 0.995 6.351744652

P03951 Coagulation factor XI 7.04 2 2 2 625 70.064 8.1 1.01 1.118 7.675900221

Q15818 Neuronal pentraxin-1 4.166667 1 2 1 432 47.093 6.55 0.918 0.922 7.621819258

P25787 Proteasome subunit alpha 8.974359 1 1 1 234 25.882 7.43 1.198 0.906 5.097272396

type-2

O00339 Matrilin-2 3.661088 2 2 2 956 106.767 6.27 0.966 1.152 7.560367107

K7ES00 Histone H3.3 (Fragment) 15.23179 3 5 3 151 16.611 11.84 1.293 0.638 11.93146896

Q92743 Serine protease HTRA1 4.375 2 3 2 480 51.255 7.83 1.062 1.05 8.923451662

Q99542 Matrix metalloproteinase-19 6.102362 2 2 2 508 57.321 7.59 0.944 0.982 6.075061798

F8WAH6 Elastin 4.707379 1 1 1 786 68.355 10.4 1.11 1.079 5.60819149

Q8IZ52 Chondroitin sulfate synthase 2 2.064516 1 1 1 775 85.414 6.93 1.015 1.013 3.241418362 P07093 Glia-derived nexin 4.522613 1 1 1 398 43.974 9.29 0.859 1.135 5.251853943

A0A075B7 Immunoglobulin heavy 17.09402 3 9 2 117 12.991 9.6 0.602 0.566 18.60829031

B6 variable 4/OR15-8 (non-

functional) (Fragment)

Q9UKZ4 Teneurin-1 1.614679 2 2 2 2725 304.817 6.42 0.924 0.942 6.949436665

P01601 Immunoglobulin kappa 13.67521 1 2 1 117 12.722 7.74 0.975 0.852 5.572105885

variable 1D-16

O60245 Protocadherin-7 1.496726 1 1 1 1069 116 5.19 0.9 0.891 4.524981976

Q8NBI6 Xyloside xylosyltransferase 1 5.597964 2 3 2 393 43.778 8.13 1.04 0.86 5.927970886

Q99674 Cell growth regulator with EF 9.966777 2 2 2 301 31.886 4.42 0.906 0.787 4.239706993

hand domain protein 1

E9PGA6 C1QTNF3-AMACR 7.042254 2 4 2 284 31.055 8.5 0.922 1.276 11.53779173

readthrough (NMD candidate)

P01602 Immunoglobulin kappa 24.78632 2 6 2 117 12.773 8.28 1.259 0.921 14.60442519

variable 1-5

P09972 Fructose-bisphosphate 6.318681 1 2 1 364 39.431 6.87 1.073 0.929 7.850584984

aldolase C

Q9NZK5 Adenosine deaminase 2 4.109589 2 3 2 511 58.895 7.91 1.295 1.119 7.421756506

P21333 Filamin-A 0.83113 2 2 2 2647 280.564 6.06 1.113 0.881 5.598319292 H0Y300 Haptoglobin 6.334842 3 3 3 442 49.074 6.64 0.982 0.943 7.540038586

Q14114 Low-density lipoprotein 3.530633 3 3 2 963 105.565 5.05 0.943 0.894 7.204383612

receptor-related protein 8

P04040 Catalase 6.83112 3 3 3 527 59.719 7.39 1.003 0.729 6.077180266

P04180 Phosphatidylcholine-sterol 5.681818 2 3 2 440 49.546 6.11 0.956 1.031 7.46651566

acyltransferase

P01706 Immunoglobulin lambda 6.722689 1 7 1 119 12.636 7.24 1.112 1.722 20.59473085

variable 2-11

Q08431 Lactadherin 6.976744 2 2 2 387 43.095 8.15 1.234 1.118 6.527766228

Q10471 Polypeptide N- 4.028021 2 3 2 571 64.691 8.35 0.82 0.952 8.085972548

acetylgalactosaminyltransfera

se 2

P29966 Myristoylated alanine-rich C- 5.421687 1 1 1 332 31.536 4.45 1.1 0.948 3.949625969

kinase substrate

P61626 Lysozyme C 16.21622 2 2 2 148 16.526 9.16 1.036 1.035 5.669743538

F5H423 Uncharacterized protein 10 2 3 2 210 23.331 8.6 0.977 0.837 7.963941574

Q6UXK2 Immunoglobulin superfamily 2.416107 1 1 1 745 78.941 5.29 0.901 0.868 3.886826277

containing leucine-rich repeat

protein 2 Q15084 Protein disulfide-isomerase 3.181818 1 1 1 440 48.091 5.08 1.238 0.824 4.055136681

O75636 Ficolin-3 8.026756 2 2 2 299 32.882 6.67 0.938 0.984 6.001326799

P02786 Transferrin receptor protein 1 2.5 2 2 2 760 84.818 6.61 1.17 0.95 5.415637732

P61769 Beta-2-microglobulin 13.44538 2 3 2 119 13.706 6.52 1.074 1.034 9.341592789

Q01955 Collagen alpha-3(IV) chain 1.796407 2 2 2 1670 161.711 9.16 0.987 0.932 3.319361448

P23284 Peptidyl-prolyl cis-trans 6.018519 1 1 1 216 23.728 9.41 0.825 0.952 3.232524395

isomerase B

A0A075B6J Immunoglobulin lambda 24.57627 2 2 2 118 12.404 4.82 1.387 1.083 6.415935516

9 variable 2-18

Q96CG8 Collagen triple helix repeat- 11.52263 3 3 3 243 26.207 7.99 0.898 1.019 4.859641075

containing protein 1

G3XAK1 Hepatocyte growth factor-like 3.862069 2 2 2 725 81.945 7.8 1.007 0.929 3.01289773

protein

E7EMB3 Calmodulin-2 19.89796 2 2 2 196 21.675 4.56 1.037 0.959 5.133591413

Q9UMF0 Intercellular adhesion 2.597403 2 2 2 924 97.056 5.95 1.055 0.962 5.514349222

molecule 5

P16870 Carboxypeptidase E 6.722689 3 3 3 476 53.117 5.14 0.947 0.904 4.358100176 Q13554 Calcium/calmodulin- 5.105105 2 2 2 666 72.632 7.27 0.762 0.789 5.976769209

dependent protein kinase type

II subunit beta

Q96PD5 N-acetylmuramoyl-L-alanine 2.256944 1 2 1 576 62.178 7.55 0.937 1.037 6.037501097

amidase

Q96SM3 Probable carboxypeptidase X1 4.223433 2 2 2 734 81.616 6.67 1.022 1.034 5.884681463

Q9ULF5 Zinc transporter ZIP10 1.684717 1 1 1 831 94.073 6.76 0.993 1.268 3.784619093

P24592 Insulin-like growth factor- 9.166667 2 2 2 240 25.306 7.81 0.985 1.007 5.570593834

binding protein 6

P48061 Stromal cell-derived factor 1 15.05376 1 1 1 93 10.659 9.88 1.049 0.986 3.496579885

P55072 Transitional endoplasmic 2.109181 1 1 1 806 89.266 5.26 1.675 0.73 3.182904959

reticulum ATPase

Q9BSG5 Retbindin 9.170306 1 1 1 229 24.599 8.18 1.032 1.021 3.65066576

E9PDN6 Contactin-associated protein- 1.525553 2 2 2 1311 145.526 6.6 0.869 0.911 5.117567062

like 4

P04217 Alpha-1B-glycoprotein 4.040404 1 1 1 495 54.22 5.86 1.095 0.984 3.140954733

Q8NFZ4 Neuroligin-2 3.233533 2 2 2 835 90.763 6.18 0.955 0.973 2.938535929

P13796 Plastin-2 2.392344 1 1 1 627 70.244 5.43 1.221 0.749 3.501815796 P46940 Ras GTPase-activating-like 1.146651 1 1 1 1657 189.134 6.48 1.321 0.854 3.867439032

protein IQGAP1

P28066 Proteasome subunit alpha 4.979253 1 1 1 241 26.394 4.79 1.416 0.901 3.646942854

type-5

P59665 Neutrophil defensin 1 19.14894 2 5 2 94 10.194 6.99 1.645 1.541 3.948067188

J3QRS3 Myosin regulatory light chain 10.16949 1 2 1 177 20.444 4.75 1.142 1.016 2.649753809

12A

Q9BUD6 Spondin-2 6.344411 1 1 1 331 35.824 5.52 0.944 0.903 3.469586849

Q6EMK4 Vasorin 2.377415 1 1 1 673 71.668 7.39 0.81 0.883 3.11607933

M9MML0 Low affinity immunoglobulin 5.292479 2 2 2 359 40.231 7.4 0.931 0.966 5.335216761

gamma Fc region receptor III-

A0A075B6 Immunoglobulin kappa 13.67521 1 2 1 117 12.68 9.25 1.086 1.015 6.831702948

S9 variable 1-37 (non-functional)

(Fragment)

P48058 Glutamate receptor 4 1.441242 1 1 1 902 100.807 8.1 0.933 1.147 3.432844877

Q15293 Reticulocalbin-1 4.531722 1 1 1 331 38.866 5 1.02 1.034 3.68230629

A0A0A0M Immunoglobulin heavy 9.401709 1 1 1 117 13.5 9.1 0.978 0.761 0

S14 variable 1-45 Q8WUJ3 Cell migration-inducing and 1.542983 2 2 2 1361 152.9 7.85 0.936 0.903 2.772236109

hyaluronan-binding protein

Q5SZK8 FRAS1-related extracellular 0.599558 1 1 1 3169 350.937 5.03 1.103 1.153 2.839387417

matrix protein 2

P21810 Biglycan 5.163043 2 2 1 368 41.628 7.52 0.869 0.9 4.777781367

P05387 60S acidic ribosomal protein 10.43478 1 1 1 115 11.658 4.54 1.26 1.033 2.487269163

A0A0C4DH Immunoglobulin kappa 10.43478 1 2 1 115 12.562 7.12 1.817 0.947 4.417459726

26 variable 6D-41 (non-

functional) (Fragment)

P26572 Alpha-1,3-mannosyl- 6.067416 2 2 2 445 50.846 9.16 0.939 0.93 5.136931658

glycoprotein 2-beta-N-

acetylglucosaminyltransferase

Q86Y38 Xylosyltransferase 1 2.502607 2 2 2 959 107.501 9.22 0.985 1.07 4.44678998

Q99983 Osteomodulin 4.275534 2 2 2 421 49.46 5.59 0.773 0.801 3.411369085

C9JEE0 Immunoglobulin lambda-like 3.888889 1 2 1 180 19.215 10.68 0.876 0.773 5.263115168

polypeptide 1 (Fragment)

Q7Z5A9 Protein FAM19A1 11.2782 1 1 1 133 14.891 8.12 0.954 1.05 3.944905758

P30530 Tyrosine-protein kinase 1.342282 1 1 1 894 98.274 5.39 1.012 1.021 2.771486044 receptor UFO

P61978 Heterogeneous nuclear 2.591793 1 2 1 463 50.944 5.54 1.367 0.696 5.50231719

ribonucleoprotein K

Q7Z304 MAM domain-containing 2.478134 1 1 1 686 77.506 5.16 0.851 0.903 3.184596062

protein 2

Q96KG7 Multiple epidermal growth 1.315789 1 1 1 1140 122.121 6.87 0.934 0.995 3.320218801

factor-like domains protein 10

D3YTG3 Target of Nesh-SH3 0.787845 1 1 1 1777 195.204 9.73 0.862 1.027 3.22381568

P01703 Immunoglobulin lambda 13.55932 1 3 1 118 12.294 5.74 0.874 0.903 8.161925554

variable 1-40

Q9NX62 Inositol monophosphatase 3 8.077994 1 1 1 359 38.657 6.86 1.188 1.007 3.717184067

P81605 Dermcidin 10 1 1 1 110 11.277 6.54 0.722 0.847 2.896159649

P22352 Glutathione peroxidase 3 5.309735 1 1 1 226 25.537 8.13 0.897 0.937 3.54316783

G8JLH6 Tetraspanin 6.772908 2 2 2 251 28.105 7.2 0.909 0.97 1.934232473

P25786 Proteasome subunit alpha 7.604563 2 2 2 263 29.537 6.61 1.049 0.896 2.58400178

type-1

Q14993 Collagen alpha-1(XIX) chain 0.788091 1 3 1 1142 115.149 8.32 0.936 0.986 2.221868992

O15144 Actin-related protein 2/3 5.333333 2 4 2 300 34.311 7.36 1.056 0.956 4.175921202 complex subunit 2

P45877 Peptidyl-prolyl cis-trans 6.132075 1 1 1 212 22.749 8.4 0.883 1.018 0

isomerase C

P26641 Elongation factor 1-gamma 2.28833 1 1 1 437 50.087 6.67 1.844 0.845 2.721371174

Q96EE4 Coiled-coil domain- 8.571429 1 1 1 140 15.658 9.88 2.274 1.543 2.30135417

containing protein 126

P07384 Calpain-1 catalytic subunit 2.521008 1 1 1 714 81.838 5.67 1.215 1.111 3.453569174

P02788 Lactotransferrin 1.690141 2 3 2 710 78.132 8.12 1.521 1.588 2.225054979

P07996 Thrombospondin-1 1.196581 1 1 1 1170 129.3 4.94 0.865 0.823 2.055860281

Q8NBP7 Proprotein convertase 1.589595 1 1 1 692 74.239 6.61 0.951 1.04 2.716536045

subtilisin/kexin type 9

J3KMX3 Alpha-fetoprotein 2.411576 1 1 1 622 70.404 5.55 1.142 0.881 2.643959284

Q16568 Cocaine- and amphetamine- 9.482759 1 1 1 116 12.821 8.25 0.549 0.707 2.36256671

regulated transcript protein

Q9UJC3 Protein Hook homolog 1 2.60989 1 3 1 728 84.595 5.15 0.696 1.06 8.252165079

Q7LFX5 Carbohydrate sulfotransferase 2.317291 1 1 1 561 64.885 8.29 0.844 0.933 2.206538439

Q8IUK5 Plexin domain-containing 4 1 1 1 500 55.725 5.85 1.11 1.029 3.356435776 protein 1

O75487 Glypican-4 3.057554 1 1 1 556 62.372 6.68 1.053 1.029 3.337503433

P07492 Gastrin-releasing peptide 6.081081 1 2 1 148 16.203 10.21 0.952 1.241 5.368754387

O75093 Slit homolog 1 protein 0.586701 1 4 1 1534 167.816 6.57 0.763 0.96 11.01824176

P20062 Transcobalamin-2 2.576112 1 1 1 427 47.505 7.01 0.911 0.911 2.305367708

E9PR17 CD59 glycoprotein 9.230769 1 1 1 130 14.519 7.77 0.919 1.105 2.393160105

P01033 Metalloproteinase inhibitor 1 5.797101 1 1 1 207 23.156 8.1 1 1.039 2.424834967

Q68DL7 Uncharacterized protein 1.021898 1 3 1 685 77.181 9.8 1.143 0.926 6.751780272

C18orf63

Q9BWP8 Collectin-11 3.690037 1 1 1 271 28.647 5.41 0.909 1.175 3.120357037

P80723 Brain acid soluble protein 1 9.251101 1 1 1 227 22.68 4.63 0.732 0.997 2.931092501

E7END6 Vitamin K-dependent protein 2.828283 1 1 1 495 55.354 6.35 0.996 0.945 2.638097763

P98155 Very low-density lipoprotein 1.489118 1 1 1 873 96.035 4.79 1.124 1.15 2.854403019

receptor

P62241 40S ribosomal protein S8 6.25 1 1 1 208 24.19 10.32 1.1 0.922 2.123716354

P34096 Ribonuclease 4 7.482993 1 1 1 147 16.829 9.03 0.9 0.863 3.053495646

Q13740 CD166 antigen 1.715266 1 1 1 583 65.061 6.25 1.129 0.944 2.626772165 B5MCX6 V-set and transmembrane 3.236246 1 1 1 309 33.834 9.32 0.785 0.928 0

domain-containing protein 2A

O95390 Growth/differentiation factor 2.948403 1 1 1 407 45.062 7.93 0.999 1.023 3.383319378

P26038 Moesin 1.733102 1 1 1 577 67.778 6.4 1.094 0.597 1.981275082

Q9BQT9 Calsyntenin-3 1.359833 1 1 1 956 106.031 5.44 0.928 0.912 2.517923832

A0A0C4DH Immunoglobulin heavy 9.482759 1 1 1 116 12.75 9.25 0.864 0.947 2.153982639

36 variable 3-38 (non-functional)

(Fragment)

P06307 Cholecystokinin 8.695652 1 2 1 115 12.661 9.01 1.371 1.155 4.437003136

O60613 Selenoprotein F 7.878788 1 1 1 165 18.081 5.03 1.087 0.871 3.059724569

P07333 Macrophage colony- 1.748971 1 1 1 972 107.915 6.37 0.916 0.936 3.36983633

stimulating factor 1 receptor

Q00973 Beta-1,4 N- 2.814259 1 1 1 533 58.846 8.69 1.215 1.116 2.988195181

acetylgalactosaminyltransfera

se 1

Q2KHR2 DNA-binding protein RFX7 0.953778 1 2 1 1363 146.804 6.76 0.667 1.407 6.537794352

H7C215 Reticulon-4 receptor 4.11449 1 1 1 559 59.519 8.43 1.115 0.926 2.909247398

(Fragment) Q9NR34 Mannosyl-oligosaccharide 3.015873 1 1 1 630 70.866 7.46 1.003 0.922 2.379423857

1,2-alpha-mannosidase IC

Q9NSB4 Keratin, type II cuticular Hb2 1.949318 1 2 1 513 56.616 6.74 0.958 1.693 2.600922346

F2Z3N3 Olfactomedin-like protein 2B 1.464714 1 1 1 751 84.075 5.2 0.973 0.878 2.778374195

A0A0B4J1 Immunoglobulin heavy 5.982906 1 1 1 117 12.909 7.11 1.103 1.201 2.589070559

V7 variable 7-81 (non-functional)

(Fragment)

O14525 Astrotactin-1 1.152074 1 1 1 1302 144.82 5.24 1.063 0.989 2.807418346

P15328 Folate receptor alpha 4.280156 1 1 1 257 29.799 7.97 0.707 0.964 2.122770786

Q04721 Neurogenic locus notch 0.445164 1 1 1 2471 265.226 5.14 0.772 0.904 2.447184801

homolog protein 2

P23280 Carbonic anhydrase 6 1.948052 1 2 1 308 35.345 7.02 0.999 0.955 2.756403685

P55287 Cadherin-11 1.507538 1 1 1 796 87.911 4.91 0.871 0.842 2.376311302

Q9NZR2 Low-density lipoprotein 0.217439 1 1 1 4599 515.159 5.3 0.877 0.902 0

receptor-related protein 1B

A0A0C4DH Immunoglobulin heavy 5.982906 1 3 1 117 12.996 9.25 0.782 0.771 4.782530069

39 variable 1-58

A0A0A0M Immunoglobulin kappa 66.66667 1 2 1 12 1.249 8.84 1.1 1.239 4.883342981

T69 joining 4 (Fragment) O14604 Thymosin beta-4, Y- 15.90909 1 1 1 44 5.009 5.36 0.749 0.798 2.542981863

chromosomal

P29401 Transketolase 3.049759 1 1 1 623 67.835 7.66 1.067 0.877 3.096656322

Q9P2E7 Protocadherin-10 1.153846 1 1 1 1040 112.866 4.87 0.771 0.839 0

Q9HC56 Protocadherin-9 0.970089 1 1 1 1237 135.981 5.47 1.068 1.194 2.525655508

A0A1B0GV Glutamine--tRNA ligase 1.358696 1 1 1 736 83.73 7.44 1.13 0.705 3.191185474

U9 (Fragment)

O14793 Growth/differentiation factor 2.666667 1 1 1 375 42.722 6.76 1.21 1.114 2.456470966

P29622 Kallistatin 3.044496 1 1 1 427 48.511 7.75 0.924 0.879 2.456081152

Q8N6R0 Methyltransferase-like protein 2.86123 1 1 1 699 78.718 6.73 1.082 0.868 2.226876736

P35590 Tyrosine-protein kinase 1.142355 1 1 1 1138 125.01 7.03 1.032 1.017 0

receptor Tie-1

A0A087WS Immunoglobulin lambda 11.38211 1 1 1 123 13.153 7.2 0.648 0.519 2.556994438

X0 variable 5-45

P62318 Small nuclear 7.142857 1 1 1 126 13.907 10.32 0.977 0.69 0

ribonucleoprotein Sm D3

P28300 Protein-lysine 6-oxidase 4.556355 1 1 1 417 46.915 8.09 0.791 0.712 2.902485847 Q14533 Keratin, type II cuticular Hb1 1.584158 1 2 1 505 54.893 5.47 1.2 1.698 0

Q92858 Protein atonal homolog 1 3.107345 1 1 1 354 38.137 8.13 0.747 0.972 2.284917593

A0A087W Thrombospondin type-1 0.4828 1 1 1 1657 185.317 7.43 0.788 0.983 0

Y08 domain-containing protein 7A

Q14520 Hyaluronan-binding protein 2 1.785714 1 2 1 560 62.63 6.54 1.019 1.001 4.699107647

P49908 Selenoprotein P 3.412073 1 1 1 381 43.156 7.87 1.038 1 2.78978014

P04083 Annexin A1 4.33526 1 1 1 346 38.69 7.02 1.157 1.186 0

Q8WZA1 ProteinO-linked-mannose 1.818182 1 1 1 660 75.204 6.83 0.937 0.832 2.276484728

beta-1,2-N-

acetylglucosaminyltransferase

O75493 Carbonic anhydrase-related 3.353659 1 2 1 328 36.216 9.74 0.81 1.031 2.672258139

protein 11

P43652 Afamin 1.168614 1 1 1 599 69.024 5.9 1.121 0.961 2.54831481

Q68CZ1 Protein fantom 1.140684 1 1 1 1315 151.107 5.35 1.047 0.995 0

Q92835 Phosphatidylinositol 3,4,5- 0.58873 1 3 1 1189 133.209 7.59 1.408 0.956 4.833375931

trisphosphate 5-phosphatase 1

H7BY55 Complement decay- 1.454545 1 1 1 550 58.873 8.78 0.691 0.757 0

accelerating factor Q13217 DnaJ homolog subfamily C 1.587302 1 1 1 504 57.544 6.15 0.882 1.05 0

member 3

Q92932 Receptor-type tyrosine-protein 0.985222 1 1 1 1015 111.202 5.83 1.128 1.203 2.087712526

phosphatase N2

Q8N126 Cell adhesion molecule 3 3.015075 1 1 1 398 43.273 6.09 0.882 0.923 0

O43866 CD5 antigen-like 2.59366 1 1 1 347 38.063 5.47 1.495 1.082 2.150546312

A0A087X1 Proteasome activator complex 5.11811 1 1 1 254 29.108 6.71 1.352 1.042 0

Z3 subunit 2

Q06830 Peroxiredoxin-1 5.527638 1 1 1 199 22.096 8.13 0.948 0.852 2.514344931

Q13519 Prepronociceptin 4.545455 1 1 1 176 20.282 8.4 0.951 1.012 2.551212311

Q9NR99 Matrix-remodeling-associated 0.318246 1 1 1 2828 311.955 8.32 0.812 1.023 2.151638746

protein 5

B7Z6Z4 cDNA FLJ56329, highly 5.462185 1 1 1 238 26.69 5.08 1.157 0.912 2.307836533

similar to Myosin light

polypeptide 6

P54803 Galactocerebrosidase 1.167883 1 1 1 685 77.015 6.64 0.746 0.85 2.248755932

Q9NT22 EMILIN-3 2.480418 1 1 1 766 82.596 7.72 0.966 0.871 2.506545067

D6R9G7 Zinc finger CCHC domain- 15.78947 1 2 1 114 13.794 10.32 0.989 1.031 4.711597443

containing protein 10 P28799 Granulins 2.360877 1 1 1 593 63.5 6.83 0.882 0.854 2.052016973

P28072 Proteasome subunit beta type- 2.92887 1 2 1 239 25.341 4.92 1.099 0.958 0

P40967 Melanocyte protein PMEL 1.059002 1 1 1 661 70.211 5.58 1.097 0.944 2.277231455

Q9GZP0 Platelet-derived growth factor 3.243243 1 1 1 370 42.821 7.97 0.952 0.892 2.431401014

A6XMV9 Protease serine 2 7.662835 1 1 1 261 27.987 5.14 0.885 0.944 2.452819824

preproprotein

Q96RT7 Gamma-tubulin complex 0.659703 1 3 1 1819 200.372 6.32 2.28 1.044 2.810472488

component 6

Q9H4F8 SPARC-related modular 2.764977 1 1 1 434 48.132 8.22 1.027 1.198 0

calcium-binding protein 1

P61158 Actin-related protein 3 1.913876 1 1 1 418 47.341 5.88 1.123 0.739 0

P78563 Double-stranded RNA- 1.214575 1 2 1 741 80.713 9.01 0.88 1.069 5.340147734

specific editase 1

Q8WX77 Insulin-like growth factor- 3.597122 1 1 1 278 28.987 7.93 0.752 0.928 2.342568874

binding protein-like 1

Q9UHB6 LIM domain and actin-binding 1.449275 1 1 1 759 85.173 6.84 0.919 0.886 2.947025061

protein 1 P17858 ATP-dependent 6- 2.179487 1 1 1 780 84.964 7.5 1.046 0.926 2.557922602

phosphofructokinase, liver

type

H0Y6Q9 Beta-1,3-N- 12.64368 1 1 1 87 9.273 9.14 0.979 0.989 0

acetylglucosaminyltransferase

manic fringe (Fragment)

Q9HCU4 Cadherin EGF LAG seven- 0.376326 1 1 1 2923 317.253 5.31 0.864 0.813 2.607527018

pass G-type receptor 2

Q86UB9 Transmembrane protein 135 3.49345 1 1 1 458 52.256 9.45 1.329 1.12 0

Q9Y5X1 Sorting nexin-9 2.352941 1 1 1 595 66.55 5.58 0.874 0.784 0

P29508 Serpin B3 1.794872 1 1 1 390 44.537 6.81 0.611 0.587 0

K7ELL7 Glucosidase 2 subunit beta 1.495327 1 1 1 535 60.154 4.41 0.926 0.804 2.130390406

Q8N6N2 Tetratricopeptide repeat 2.51046 1 2 1 239 25.916 9.48 0.973 0.992 4.827381849

protein 9B

P62191 26S proteasome regulatory 2.045455 1 1 1 440 49.154 6.21 1.35 1.093 2.048808813

subunit 4

P62993 Growth factor receptor-bound 6.451613 1 1 1 217 25.19 6.32 1.258 0.916 0

protein 2

A8K070 COP9 signalosome complex 1.140684 1 1 1 526 58.885 6.32 0.626 0.829 2.348926544 subunit 1

Q8TF72 Protein Shroom3 0.300601 1 1 1 1996 216.724 7.8 0.863 0.993 2.169522762

P25789 Proteasome subunit alpha 3.065134 1 1 1 261 29.465 7.72 1.057 0.819 2.442546844

type-4

Table SII. A total of 186 differentially expressed proteins identified by tandem mass spectrometry in microvesicles/exosomes between the severe group and moderate group.

A, Downregulated differentially expressed proteins (111 in total)

Accession Description Coverage Peptides PSMs Unique AAs Molecular weight (kDa) calc. pI Abundance ratio: Score Sequest HT

Peptides Severe/moderate

P0C0L5 Complement C4-B 66.800459 89 1289 1 1744 192.631 7.27 1.49269 4859.406727

Q9Y6R7 IgGFc-binding protein 27.715079 68 305 68 5405 571.639 5.34 0.68146 981.3557811

P02647 Apolipoprotein A-I 77.153558 24 385 24 267 30.759 5.76 0.80427 1253.797316

A0A286YEY4 Immunoglobulin heavy constant 54.43038 17 719 8 395 43.778 6.52 0.55824 2565.892901

gamma 2 (Fragment)

Q86VB7 Scavenger receptor cysteine-rich 34.775087 29 98 29 1156 125.369 5.95 0.67955 329.5928527

type 1 protein M130

P0DOY2 Immunoglobulin lambda 93.396226 9 391 2 106 11.287 7.24 0.82316 1610.298396

constant 2

P19827 Inter-alpha-trypsin inhibitor 26.783754 18 58 18 911 101.326 6.79 0.82784 202.5168812

heavy chain H1

P60709 Actin, cytoplasmic 1 37.066667 10 39 4 375 41.71 5.48 0.74787 141.0285643 P69892 Hemoglobin subunit gamma-2 88.435374 12 64 1 147 16.116 7.2 0.64714 196.0103188

A0A2R8Y7X9 Uncharacterized protein 86.904762 12 64 1 168 18.409 6.96 0.82541 200.0579996

P02746 Complement C1q subcomponent 41.501976 7 51 7 253 26.704 8.63 0.82171 182.5711771

subunit B

P01772 Immunoglobulin heavy variable 37.606838 4 74 1 117 13.065 8.94 0.72694 179.8079971

3-33

P08670 Vimentin 33.04721 14 28 14 466 53.619 5.12 0.69096 86.31107831

A0A0C4DH41 Immunoglobulin heavy variable 44.067797 4 44 2 118 13.058 9.29 0.7308 121.7412282

4-61

P01762 Immunoglobulin heavy variable 53.846154 4 58 2 117 12.9 8.6 0.76396 139.7722524

3-11

P02747 Complement C1q subcomponent 21.22449 4 31 4 245 25.757 8.41 0.77662 112.9564657

subunit C

P10451 Osteopontin 13.375796 3 34 3 314 35.401 4.58 0.73964 127.6464496

P62736 Actin, aortic smooth muscle 22.015915 7 27 1 377 41.982 5.39 0.80811 82.49907935 P01763 Immunoglobulin heavy variable 35.042735 3 57 1 117 12.804 5.36 0.76058 138.5215894

3-48

P01767 Immunoglobulin heavy variable 37.068966 3 53 1 116 12.761 8.28 0.82749 139.5994531

3-53

P23083 Immunoglobulin heavy variable 26.495726 3 47 1 117 13.076 9.13 0.62569 103.3184353

1-2

P01742 Immunoglobulin heavy variable 45.299145 5 47 2 117 12.651 9.17 0.56974 92.87927413

1-69

P04433 Immunoglobulin kappa variable 58.26087 4 28 3 115 12.567 4.96 0.79727 72.31677985

3-11

P06312 Immunoglobulin kappa variable 34.710744 4 46 4 121 13.372 5.25 0.73993 111.6955808

4-1

A0A0C4DH73 Immunoglobulin kappa variable 29.059829 2 46 1 117 12.637 8.31 0.71983 159.1169224

1-12

P00488 Coagulation factor XIII A chain 16.530055 9 18 9 732 83.215 6.09 0.6574 53.4234997 A0A0C4DH69 Immunoglobulin kappa variable 29.059829 2 24 1 117 12.706 8.29 0.70407 102.5505395

1-9

P31146 Coronin-1A 23.427332 9 11 9 461 50.994 6.68 0.67875 37.99821258

P02792 Ferritin light chain 28.571429 4 18 4 175 20.007 5.78 0.40818 47.40906429

A0A0B4J1X8 Immunoglobulin heavy variable 34.745763 3 26 2 118 13.068 5.41 0.75883 55.60068369

3-43

P62805 Histone H4 51.456311 6 18 6 103 11.36 11.36 0.50849 42.72476315

A0A087X0Q4 Immunoglobulin kappa variable 50 3 19 3 104 11.427 4.49 0.67114 67.15511155

2-40

A0A087WVQ6 Clathrin heavy chain 7.3853484 10 13 10 1679 191.936 5.69 0.80752 35.45963311

A0A0B4J1Y9 Immunoglobulin heavy variable 35.294118 4 23 2 119 13.194 7.85 0.82558 44.69129026

3-72

A0A075B6S5 Immunoglobulin kappa variable 29.059829 2 23 1 117 12.703 8.29 0.68803 99.54478717

1-27

P07900 Heat shock protein HSP 90-alpha 13.114754 9 15 3 732 84.607 5.02 0.59925 44.34405565

P68363 Tubulin alpha-1B chain 19.068736 6 9 1 451 50.12 5.06 0.7748 32.49740529 Q71U36 Tubulin alpha-1A chain 19.068736 6 8 1 451 50.104 5.06 0.82086 29.61507583

P07437 Tubulin beta chain 19.594595 6 7 6 444 49.639 4.89 0.79061 24.50897264

A0A075B7E8 Immunoglobulin heavy variable 24.786325 3 22 1 117 12.895 8.31 0.79011 50.11345041

3/OR16-13 (non-functional)

(Fragm

P35579 Myosin-9 4.5408163 6 6 6 1960 226.392 5.6 0.72927 18.66729665

P08238 Heat shock protein HSP 90-beta 11.878453 8 13 1 724 83.212 5.03 0.53881 37.95699954

U3KQK0 Histone H2B 24.698795 4 11 4 166 18.792 10.54 0.46231 29.86686897

P34931 Heat shock 70 kDa protein 1-like 9.6723869 4 8 2 641 70.331 6.02 0.7305 25.13015938

P80748 Immunoglobulin lambda variable 23.076923 2 8 2 117 12.438 5.29 0.82771 29.86564922

3-21

Q9Y490 Talin-1 OS=Homo sapiens 3.227076 4 4 4 2541 269.599 6.07 0.69572 13.91558695

OX=9606 GN=TLN1 PE=1

SV=3

A0A0C4DH35 Immunoglobulin heavy variable 16.239316 2 10 2 117 12.802 7.88 0.82555 24.93146586

3-35 (non-functional) (Fragment) P68104 Elongation factor 1-alpha 1 19.480519 6 8 6 462 50.109 9.01 0.74268 21.43942118

Q06033 Inter-alpha-trypsin inhibitor 7.6404494 5 5 5 890 99.787 5.74 0.74958 17.40087748

heavy chain H3

A0A075B6R9 Immunoglobulin kappa variable 16.666667 2 8 2 120 13.071 8.87 0.72304 24.2537272

2D-24 (non-functional)

(Fragment)

A0A0U1RRH7 Histone H2A OS=Homo sapiens 20.588235 3 6 3 170 18.541 11.52 0.36564 25.5635848

OX=9606 PE=3 SV=1

P04430 Immunoglobulin kappa variable 29.059829 2 4 2 117 12.61 8.16 0.73491 16.53339887

1-16

P01714 Immunoglobulin lambda variable 34.821429 2 6 2 112 12.035 4.96 0.80141 17.55187321

3-19

A0A0C4DH33 Immunoglobulin heavy variable 40.17094 3 17 2 117 12.816 5.16 0.69931 43.22818255

1-24

A0A0C4DH34 Immunoglobulin heavy variable 44.444444 4 15 2 117 13.116 9.29 0.70195 32.19099617

4-28 P04211 Immunoglobulin lambda variable 15.384615 2 7 1 117 12.443 7.03 0.5158 19.63640356

7-43

E7EX29 14-3-3 protein zeta/delta 15.04065 3 3 1 246 28.019 4.92 0.79128 10.30245829

(Fragment)

P62258 14-3-3 protein epsilon 14.509804 3 3 1 255 29.155 4.74 0.7202 10.48452115

Q01518 Adenylyl cyclase-associated 9.4736842 4 6 4 475 51.869 8.06 0.74298 14.48113203

protein 1

A0A087WSZ0 Immunoglobulin kappa variable 16.239316 1 2 1 117 12.828 7.74 0.78723 9.84670496

1D-8

A0A0B4J1Y8 Immunoglobulin lambda variable 16.260163 2 4 2 123 13.016 7.28 0.67738 11.32931447

9-49

A0A0G2JRQ6 Uncharacterized protein 13.675214 2 18 2 117 12.74 8.29 0.42831 37.33334506

(Fragment)

P11142 Heat shock cognate 71 kDa 5.7275542 3 6 1 646 70.854 5.52 0.77854 16.45200515

protein A0A075B6Q5 Immunoglobulin heavy variable 18.644068 2 6 2 118 12.882 7.85 0.7747 10.81513023

3-64

J3KN67 Tropomyosin alpha-3 chain 13.333333 4 5 4 285 33.202 4.77 0.73739 11.92337799

Q9Y3Z3 Deoxynucleoside triphosphate 6.8690096 3 3 3 626 72.155 7.14 0.70847 5.907426596

triphosphohydrolase SAMHD1

P28838 Cytosol aminopeptidase 5.3949904 2 3 2 519 56.131 7.93 0.73906 6.660748482

A0A0B4J1U7 Immunoglobulin heavy variable 21.487603 3 19 3 121 13.473 9.2 0.51022 32.06293344

6-1

A0A0B4J1U3 Immunoglobulin lambda variable 13.675214 1 4 1 117 12.47 4.78 0.68872 13.01889586

1-36

P02794 Ferritin heavy chain 14.20765 2 2 2 183 21.212 5.55 0.73226 6.528439045

A0A075B6I9 Immunoglobulin lambda variable 15.384615 2 6 1 117 12.46 7.2 0.6343 17.20948243

7-46

P61160 Actin-related protein 2 6.0913706 2 2 2 394 44.732 6.74 0.74379 6.874537468

Q96NU0 Contactin-associated protein-like 1.9409938 2 2 2 1288 140.326 7.4 0.8 6.16936326

3B P25787 Proteasome subunit alpha type-2 8.974359 1 1 1 234 25.882 7.43 0.75648 5.097272396

K7ES00 Histone H3.3 (Fragment) 15.231788 3 5 3 151 16.611 11.84 0.49358 11.93146896

Q8NBI6 Xyloside xylosyltransferase 1 5.5979644 2 3 2 393 43.778 8.13 0.82621 5.927970886

P01602 Immunoglobulin kappa variable 24.786325 2 6 2 117 12.773 8.28 0.73148 14.60442519

1-5

P21333 Filamin-A 0.8311296 2 2 2 2647 280.564 6.06 0.79193 5.598319292

P04040 Catalase 6.8311195 3 3 3 527 59.719 7.39 0.72686 6.077180266

Q15084 Protein disulfide-isomerase A6 3.1818182 1 1 1 440 48.091 5.08 0.66529 4.055136681

P02786 Transferrin receptor protein 1 2.5 2 2 2 760 84.818 6.61 0.81244 5.415637732

A0A075B6J9 Immunoglobulin lambda variable 24.576271 2 2 2 118 12.404 4.82 0.78065 6.415935516

2-18

P55072 Transitional endoplasmic 2.1091811 1 1 1 806 89.266 5.26 0.43564 3.182904959

reticulum ATPase

P13796 Plastin-2 2.3923445 1 1 1 627 70.244 5.43 0.61395 3.501815796

P46940 Ras GTPase-activating-like 1.1466506 1 1 1 1657 189.134 6.48 0.64663 3.867439032

protein IQGAP1 P28066 Proteasome subunit alpha type-5 4.9792531 1 1 1 241 26.394 4.79 0.63622 3.646942854

P59665 Neutrophil defensin 1 19.148936 2 5 2 94 10.194 6.99 1.65433 3.948067188

A0A0A0MS14 Immunoglobulin heavy variable 9.4017094 1 1 1 117 13.5 9.1 0.77871 0

1-45

P05387 60S acidic ribosomal protein P2 10.434783 1 1 1 115 11.658 4.54 0.81969 2.487269163

A0A0C4DH26 Immunoglobulin kappa variable 10.434783 1 2 1 115 12.562 7.12 0.52141 4.417459726

6D-41 (non-functional)

(Fragment)

P61978 Heterogeneous nuclear 2.5917927 1 2 1 463 50.944 5.54 0.50859 5.50231719

ribonucleoprotein K

P26641 Elongation factor 1-gamma 2.2883295 1 1 1 437 50.087 6.67 0.458 2.721371174

Q96EE4 Coiled-coil domain-containing 8.5714286 1 1 1 140 15.658 9.88 0.67867 2.30135417

protein 126

J3KMX3 Alpha-fetoprotein 2.4115756 1 1 1 622 70.404 5.55 0.77229 2.643959284

Q68DL7 Uncharacterized protein 1.0218978 1 3 1 685 77.181 9.8 0.81021 6.751780272

C18orf63 P26038 Moesin 1.7331023 1 1 1 577 67.778 6.4 0.5459 1.981275082

O60613 Selenoprotein F 7.8787879 1 1 1 165 18.081 5.03 0.80218 3.059724569

P29401 Transketolase 3.0497592 1 1 1 623 67.835 7.66 0.82245 3.096656322

A0A1B0GVU9 Glutamine--tRNA ligase 1.3586957 1 1 1 736 83.73 7.44 0.62375 3.191185474

(Fragment)

Q8N6R0 Methyltransferase-like protein 13 2.8612303 1 1 1 699 78.718 6.73 0.80109 2.226876736

A0A087WSX0 Immunoglobulin lambda variable 11.382114 1 1 1 123 13.153 7.2 0.80156 2.556994438

5-45

P62318 Small nuclear ribonucleoprotein 7.1428571 1 1 1 126 13.907 10.32 0.7061 0

Sm D3

Q92835 Phosphatidylinositol 3,4,5- 0.58873 1 3 1 1189 133.209 7.59 0.67968 4.833375931

trisphosphate 5-phosphatase 1

O43866 CD5 antigen-like 2.5936599 1 1 1 347 38.063 5.47 0.72329 2.150546312

A0A087X1Z3 Proteasome activator complex 5.1181102 1 1 1 254 29.108 6.71 0.77071 0

subunit 2 B7Z6Z4 cDNA FLJ56329, highly similar 5.4621849 1 1 1 238 26.69 5.08 0.78868 2.307836533

to Myosin light polypeptide 6

Q96RT7 Gamma-tubulin complex 0.6597031 1 3 1 1819 200.372 6.32 0.45765 2.810472488

component 6

P61158 Actin-related protein 3 1.9138756 1 1 1 418 47.341 5.88 0.65845 0

P62191 26S proteasome regulatory 2.0454545 1 1 1 440 49.154 6.21 0.81037 2.048808813

subunit 4

P62993 Growth factor receptor-bound 6.4516129 1 1 1 217 25.19 6.32 0.7275 0

protein 2

P25789 Proteasome subunit alpha type-4 3.0651341 1 1 1 261 29.465 7.72 0.77425 2.442546844

B, Upregulated differentially expressed proteins (75 in total)

Accession Description Coverage Peptides PSMs Unique AAs Molecular calc. Abundance Score

Peptides weight pI ratio: Sequest HT

(kDa) Severe/moderate P02751 Fibronectin 56.03521 87 960 87 2386 262.46 5.71 1.249127 3458.332983

Q12860 Contactin-1 56.87623 46 242 46 1018 113.249 5.9 1.288996 816.1462975

P10643 Complement component C7 50.05931 29 156 29 843 93.457 6.48 1.2237 573.7836608

Q7Z7M0 Multiple epidermal growth factor-like domains 20.0703 40 121 40 2845 302.901 6.87 1.284698 432.9133862

protein 8

P14543 Nidogen-1 41.94066 38 129 37 1247 136.291 5.29 1.215402 452.404595

E7ERL8 Neurexin-1-beta 36.09821 39 126 28 1507 165.341 5.96 1.24186 392.0663251

P06727 Apolipoprotein A-IV 75.75758 31 154 31 396 45.371 5.38 1.222382 511.2329108

Q08380 Galectin-3-binding protein 44.2735 22 188 22 585 65.289 5.27 1.595084 656.6998068

P04264 Keratin, type II cytoskeletal 1 43.47826 27 137 24 644 65.999 8.12 1.256627 416.9153267

E7EUF1 Ectonucleotide pyrophosphatase/phosphodiesterase 35.181 26 116 26 884 101.488 7.53 1.43681 414.4653013

family member 2

Q12805 EGF-containing fibulin-like extracellular matrix 50.10142 19 91 5 493 54.604 5.07 1.260069 345.0832398

protein 1

P10909 Clusterin 37.86192 19 259 19 449 52.461 6.27 1.637701 816.842995

Q13332 Receptor-type tyrosine-protein phosphatase S 18.94251 23 80 1 1948 216.905 6.46 1.236607 268.2885706 M0R0Q9 Complement C3 (Fragment) 84.15842 6 130 1 101 11.148 4.77 1.200644 506.8810011

P51693 Amyloid-like protein 1 28.61538 18 106 18 650 72.131 5.8 1.235995 398.4112236

Q9P2S2 Neurexin-2 26.10981 37 96 33 1712 184.865 5.92 1.200903 317.2764077

P01034 Cystatin-C 62.32877 8 103 8 146 15.789 8.75 1.503177 433.4969542

A0A1W2PQ11 Contactin-2 31.6129 24 61 24 1085 118.208 7.55 1.224745 210.001472

P32004 Neural cell adhesion molecule L1 28.00318 31 58 30 1257 139.915 6.24 1.220436 165.0750264

P07358 Complement component C8 beta chain 35.8714 17 46 17 591 67.003 8.13 1.202198 151.0469677

P12109 Collagen alpha-1(VI) chain 26.84825 22 56 22 1028 108.462 5.43 1.266515 173.1234797

Q96GW7 Brevican core protein 32.05269 21 54 20 911 99.056 4.64 1.411905 142.861371

A0M8Q6 Immunoglobulin lambda constant 7 62.26415 6 286 2 106 11.247 8.29 1.389849 1252.272737

P01019 Angiotensinogen 24.94845 9 29 9 485 53.121 6.32 1.380542 112.7987204

P05060 Secretogranin-1 18.75923 12 42 12 677 78.229 5.07 1.518578 122.1391906

Q8WXD2 Secretogranin-3 40.81197 18 35 18 468 52.973 5.03 1.21789 104.849102

P05546 Heparin cofactor 2 28.65731 13 38 13 499 57.034 6.9 1.221142 89.73312998

P41222 Prostaglandin-H2 D-isomerase 24.73684 4 36 4 190 21.015 7.8 1.249415 129.7730234

F6SYF8 Dickkopf-related protein 3 30.21978 8 24 8 364 39.924 4.7 1.252326 89.94954038 O15240 Neurosecretory protein VGF 18.53659 9 24 9 615 67.218 4.78 1.278555 88.6339159

P21246 Pleiotrophin 45.83333 7 28 7 168 18.93 9.6 1.649626 83.90634847

B0YIW2 Apolipoprotein C-III variant 1 29.05983 4 28 4 117 12.807 8.18 1.342373 96.72932458

P07360 Complement component C8 gamma chain 58.91089 7 19 7 202 22.264 8.31 1.214518 58.55921876

A0A0D9SF36 Neurexin-1-beta (Fragment) 38.49765 7 20 1 213 23.008 6.32 1.245219 59.34383881

Q99784 Noelin 14.43299 7 12 7 485 55.307 6.95 1.208381 24.06632328

P06276 Cholinesterase 13.62126 7 11 7 602 68.374 7.42 1.370146 31.51544464

P23471 Receptor-type tyrosine-protein phosphatase zeta 3.36933 7 9 7 2315 254.429 4.88 1.354369 28.14834929

A0A096LPE2 SAA2-SAA4 readthrough 24.51923 5 13 3 208 23.338 8.98 1.382629 38.32234967

P17900 Ganglioside GM2 activator 40.93264 5 10 5 193 20.825 5.31 1.235849 33.73345375

P35052 Glypican-1 13.62007 5 7 5 558 61.641 7.3 1.225195 19.84249425

P19021 Peptidyl-glycine alpha-amidating monooxygenase 7.29702 7 10 7 973 108.263 6.42 1.205814 22.97336459

P07585 Decorin 12.81337 5 7 4 359 39.722 8.54 1.276817 21.93158746

P19652 Alpha-1-acid glycoprotein 2 21.89055 4 6 2 201 23.588 5.11 1.36405 14.83352566

A0A286YEY1 Immunoglobulin heavy constant alpha 1 (Fragment) 16.83417 5 6 5 398 42.821 5.64 1.443195 19.30940413

Q16849 Receptor-type tyrosine-protein phosphatase-like N 3.064351 2 3 2 979 105.781 7.11 1.259524 10.44954824 P61278 Somatostatin 16.37931 2 9 2 116 12.727 5.52 1.35533 27.66441822

Q06481 Amyloid-like protein 2 3.145478 2 3 1 763 86.9 4.79 1.608764 8.72531271

H7C4X7 Neuroendocrine protein 7B2 (Fragment) 8.333333 1 2 1 216 24.039 6.52 1.240139 7.56017375

Q14118 Dystroglycan 4.134078 3 4 3 895 97.381 8.56 1.330467 12.05706

A0A0B4J1V2 Immunoglobulin heavy variable 2-26 17.64706 2 7 2 119 13.174 8.29 1.501827 6.610331297

P23435 Cerebellin-1 13.98964 3 5 3 193 21.084 7.28 1.288136 12.48828781

Q12841 Follistatin-related protein 1 9.090909 3 4 3 308 34.963 5.52 1.2486 9.8314147

P07093 Glia-derived nexin 4.522613 1 1 1 398 43.974 9.29 1.320557 5.251853943

E9PGA6 C1QTNF3-AMACR readthrough (NMD candidate) 7.042254 2 4 2 284 31.055 8.5 1.383815 11.53779173

P01706 Immunoglobulin lambda variable 2-11 6.722689 1 7 1 119 12.636 7.24 1.549425 20.59473085

Q9ULF5 Zinc transporter ZIP10 1.684717 1 1 1 831 94.073 6.76 1.278204 3.784619093

P48058 Glutamate receptor 4 1.441242 1 1 1 902 100.807 8.1 1.228823 3.432844877

Q16568 Cocaine- and amphetamine-regulated transcript 9.482759 1 1 1 116 12.821 8.25 1.287671 2.36256671

protein

Q9UJC3 Protein Hook homolog 1 2.60989 1 3 1 728 84.595 5.15 1.522427 8.252165079

P07492 Gastrin-releasing peptide 6.081081 1 2 1 148 16.203 10.21 1.302793 5.368754387 O75093 Slit homolog 1 protein 0.586701 1 4 1 1534 167.816 6.57 1.259524 11.01824176

E9PR17 CD59 glycoprotein 9.230769 1 1 1 130 14.519 7.77 1.201754 2.393160105

Q9BWP8 Collectin-11 3.690037 1 1 1 271 28.647 5.41 1.292986 3.120357037

P80723 Brain acid soluble protein 1 9.251101 1 1 1 227 22.68 4.63 1.361491 2.931092501

Q2KHR2 DNA-binding protein RFX7 0.953778 1 2 1 1363 146.804 6.76 2.109063 6.537794352

Q9NSB4 Keratin, type II cuticular Hb2 1.949318 1 2 1 513 56.616 6.74 1.767471 2.600922346

P15328 Folate receptor alpha 4.280156 1 1 1 257 29.799 7.97 1.36398 2.122770786

Q14533 Keratin, type II cuticular Hb1 1.584158 1 2 1 505 54.893 5.47 1.416035 0

Q92858 Protein atonal homolog 1 3.107345 1 1 1 354 38.137 8.13 1.299394 2.284917593

A0A087WY08 Thrombospondin type-1 domain-containing protein 0.4828 1 1 1 1657 185.317 7.43 1.247362 0

O75493 Carbonic anhydrase-related protein 11 3.353659 1 2 1 328 36.216 9.74 1.273684 2.672258139

Q9NR99 Matrix-remodeling-associated protein 5 0.318246 1 1 1 2828 311.955 8.32 1.259604 2.151638746

P78563 Double-stranded RNA-specific editase 1 1.214575 1 2 1 741 80.713 9.01 1.21317 5.340147734

Q8WX77 Insulin-like growth factor-binding protein-like 1 3.597122 1 1 1 278 28.987 7.93 1.235434 2.342568874

A8K070 COP9 signalosome complex subunit 1 1.140684 1 1 1 526 58.885 6.32 1.324183 2.348926544 Table SIII. A total of 119 differentially expressed proteins were identified by tandem mass spectrometry in the microvesicles/exosomes between the severe group and control group.

A, Downregulated differentially expressed proteins (82 in total) Accession Description Coverage Peptides PSMs Unique AAs Molecular calc. pI Abundance ratio: Score Sequest HT Peptides weight Severe/control (kDa) O00533 Neural cell adhesion 42.88079 38 220 37 1208 134.987 5.76 0.827 804.1383946 molecule L1-like protein Q99435 Protein kinase C-binding 49.63235 30 216 30 816 91.284 5.73 0.823 715.4273092 protein NELL2 B4E1Z4 cDNA FLJ55673, highly 39.9684 46 160 29 1266 140.853 7.18 0.611 494.6025889 similar to Complement factor B P01860 Immunoglobulin heavy 61.00796 20 778 8 377 41.26 7.9 0.785 2633.157825 constant gamma 3 P06727 Apolipoprotein A-IV 75.75758 31 154 31 396 45.371 5.38 0.587 511.2329108 Q86VB7 Scavenger receptor 34.77509 29 98 29 1156 125.369 5.95 0.757 329.5928527 cysteine-rich type 1 protein M130 P23468 Receptor-type tyrosine- 19.66527 27 61 2 1912 214.625 6.57 0.821 204.8723233 protein phosphatase delta P01009 Alpha-1-antitrypsin 46.65072 20 69 20 418 46.707 5.59 0.827 223.3318003 Q8TEU8 WAP, Kazal, 33.50694 15 41 15 576 63.898 6.21 0.78 130.4619564 immunoglobulin, Kunitz and NTR domain- containing protein 2 Q16610 Extracellular matrix 37.40741 15 50 15 540 60.635 6.71 0.818 163.9129673 protein 1 P01772 Immunoglobulin heavy 37.60684 4 74 1 117 13.065 8.94 0.738 179.8079971 variable 3-33 P05060 Secretogranin-1 18.75923 12 42 12 677 78.229 5.07 0.653 122.1391906 P08670 Vimentin 33.04721 14 28 14 466 53.619 5.12 0.642 86.31107831 P02538 Keratin, type II 21.63121 12 32 3 564 60.008 8 0.765 92.53173935 cytoskeletal 6A C9JV77 Alpha-2-HS- 26.08696 8 22 8 368 39.387 5.72 0.788 76.79577923 glycoprotein P69905 Hemoglobin subunit 50.70423 5 36 5 142 15.248 8.68 0.629 121.9940966 alpha P23083 Immunoglobulin heavy 26.49573 3 47 1 117 13.076 9.13 0.555 103.3184353 variable 1-2 Q9Y279 V-set and 28.82206 8 21 8 399 43.959 6.35 0.655 61.2986939 immunoglobulin domain-containing protein 4 P01011 Alpha-1- 23.40426 8 18 8 423 47.621 5.52 0.809 65.44287133 antichymotrypsin P01742 Immunoglobulin heavy 45.29915 5 47 2 117 12.651 9.17 0.59 92.87927413 variable 1-69 P68871 Hemoglobin subunit 68.02721 8 29 7 147 15.988 7.28 0.667 84.50491452 beta P00488 Coagulation factor XIII 16.53005 9 18 9 732 83.215 6.09 0.827 53.4234997 A chain P62805 Histone H4 51.45631 6 18 6 103 11.36 11.36 0.721 42.72476315 A0A0J9YXX1 Immunoglobulin heavy 26.49573 3 17 1 117 12.764 8.28 0.213 53.36616898 variable 5-10-1 P06702 Protein S100-A9 55.26316 5 16 5 114 13.234 6.13 0.478 46.12688518 P00742 Coagulation factor X 17.0082 7 11 7 488 54.697 5.94 0.749 28.57849181 A0A075B7E8 Immunoglobulin heavy 24.78632 3 22 1 117 12.895 8.31 0.782 50.11345041 variable 3/OR16-13 (non-functional) (Fragment) P08238 Heat shock protein HSP 11.87845 8 13 1 724 83.212 5.03 0.77 37.95699954 90-beta U3KQK0 Histone H2B 24.6988 4 11 4 166 18.792 10.54 0.669 29.86686897 P19320 Vascular cell adhesion 11.77267 8 8 8 739 81.224 5.22 0.774 21.89148533 protein 1 P68104 Elongation factor 1- 19.48052 6 8 6 462 50.109 9.01 0.807 21.43942118 alpha 1 P31151 Protein S100-A7 33.66337 3 6 3 101 11.464 6.77 0.466 19.76926899 A0A0U1RRH7 Histone H2A 20.58824 3 6 3 170 18.541 11.52 0.572 25.5635848 P01699 Immunoglobulin lambda 38.46154 2 7 1 117 12.194 5.17 0.812 18.83399343 variable 1-44 A0A0C4DH33 Immunoglobulin heavy 40.17094 3 17 2 117 12.816 5.16 0.797 43.22818255 variable 1-24 E7EX29 14-3-3 protein zeta/delta 15.04065 3 3 1 246 28.019 4.92 0.798 10.30245829 (Fragment) O94772 Lymphocyte antigen 6H 22.14286 3 6 3 140 14.659 7.25 0.797 14.21915698 A0A0C4DH43 Immunoglobulin heavy 24.36975 2 6 1 119 13.304 8.29 0.163 17.26096582 variable 2-70D P01701 Immunoglobulin lambda 38.46154 3 9 3 117 12.241 7.03 0.757 19.60087895 variable 1-51 A0A0B4J1Y8 Immunoglobulin lambda 16.26016 2 4 2 123 13.016 7.28 0.383 11.32931447 variable 9-49 Q06481 Amyloid-like protein 2 3.145478 2 3 1 763 86.9 4.79 0.771 8.72531271 P01717 Immunoglobulin lambda 18.75 2 18 1 112 12.004 4.5 0.727 53.72631598 variable 3-25 P16401 Histone H1.5 14.60177 4 6 1 226 22.566 10.92 0.808 16.3841151 P08758 Annexin A5 9.6875 2 2 2 320 35.914 5.05 0.702 7.304258108 Q13867 Bleomycin hydrolase 10.98901 5 6 5 455 52.528 6.27 0.813 10.39226937 A0A075B7D0 Immunoglobulin heavy 27.35043 3 22 2 117 13.003 9.13 0.607 53.07422614 variable 1/OR15-1 (non- functional) (Fragment) A0A075B6Q5 Immunoglobulin heavy 18.64407 2 6 2 118 12.882 7.85 0.779 10.81513023 variable 3-64 A0A075B6I0 Immunoglobulin lambda 14.7541 2 6 2 122 12.806 4.55 0.599 18.62005115 variable 8-61 A0A0B4J1U3 Immunoglobulin lambda 13.67521 1 4 1 117 12.47 4.78 0.623 13.01889586 variable 1-36 A0A1X7SBT7 Neuronal pentraxin 4.6 2 4 2 500 52.795 6.21 0.803 11.35587358 receptor P05109 Protein S100-A8 31.1828 3 5 3 93 10.828 7.03 0.676 10.32500505 P15814 Immunoglobulin 7.042254 1 2 1 213 22.949 10.07 0.798 7.219301462 lambda-like polypeptide 1 A0A075B6I9 Immunoglobulin lambda 15.38462 2 6 1 117 12.46 7.2 0.799 17.20948243 variable 7-46 K7ES00 Histone H3.3 15.23179 3 5 3 151 16.611 11.84 0.638 11.93146896 (Fragment) A0A075B7B6 Immunoglobulin heavy 17.09402 3 9 2 117 12.991 9.6 0.566 18.60829031 variable 4/OR15-8 (non- functional) (Fragment) Q99674 Cell growth regulator 9.966777 2 2 2 301 31.886 4.42 0.787 4.239706993 with EF hand domain protein 1 P04040 Catalase 6.83112 3 3 3 527 59.719 7.39 0.729 6.077180266 Q15084 Protein disulfide- 3.181818 1 1 1 440 48.091 5.08 0.824 4.055136681 isomerase A6 Q13554 Calcium/calmodulin- 5.105105 2 2 2 666 72.632 7.27 0.789 5.976769209 dependent protein kinase type II subunit beta P55072 Transitional 2.109181 1 1 1 806 89.266 5.26 0.73 3.182904959 endoplasmic reticulum ATPase P13796 Plastin-2 2.392344 1 1 1 627 70.244 5.43 0.749 3.501815796 A0A0A0MS14 Immunoglobulin heavy 9.401709 1 1 1 117 13.5 9.1 0.761 0 variable 1-45 Q99983 Osteomodulin 4.275534 2 2 2 421 49.46 5.59 0.801 3.411369085 C9JEE0 Immunoglobulin 3.888889 1 2 1 180 19.215 10.68 0.773 5.263115168 lambda-like polypeptide 1 (Fragment) P61978 Heterogeneous nuclear 2.591793 1 2 1 463 50.944 5.54 0.696 5.50231719 ribonucleoprotein K P07996 Thrombospondin-1 1.196581 1 1 1 1170 129.3 4.94 0.823 2.055860281 Q16568 Cocaine- and 9.482759 1 1 1 116 12.821 8.25 0.707 2.36256671 amphetamine-regulated transcript protein P26038 Moesin 1.733102 1 1 1 577 67.778 6.4 0.597 1.981275082 A0A0C4DH39 Immunoglobulin heavy 5.982906 1 3 1 117 12.996 9.25 0.771 4.782530069 variable 1-58 O14604 Thymosin beta-4, Y- 15.90909 1 1 1 44 5.009 5.36 0.798 2.542981863 chromosomal A0A1B0GVU9 Glutamine--tRNA ligase 1.358696 1 1 1 736 83.73 7.44 0.705 3.191185474 (Fragment) A0A087WSX0 Immunoglobulin lambda 11.38211 1 1 1 123 13.153 7.2 0.519 2.556994438 variable 5-45 P62318 Small nuclear 7.142857 1 1 1 126 13.907 10.32 0.69 0 ribonucleoprotein Sm D3 P28300 Protein-lysine 6-oxidase 4.556355 1 1 1 417 46.915 8.09 0.712 2.902485847 H7BY55 Complement decay- 1.454545 1 1 1 550 58.873 8.78 0.757 0 accelerating factor P61158 Actin-related protein 3 1.913876 1 1 1 418 47.341 5.88 0.739 0 Q9HCU4 Cadherin EGF LAG 0.376326 1 1 1 2923 317.253 5.31 0.813 2.607527018 seven-pass G-type receptor 2 Q9Y5X1 Sorting nexin-9 2.352941 1 1 1 595 66.55 5.58 0.784 0 P29508 Serpin B3 1.794872 1 1 1 390 44.537 6.81 0.587 0 K7ELL7 Glucosidase 2 subunit 1.495327 1 1 1 535 60.154 4.41 0.804 2.130390406 beta A8K070 COP9 signalosome 1.140684 1 1 1 526 58.885 6.32 0.829 2.348926544 complex subunit 1 P25789 Proteasome subunit 3.065134 1 1 1 261 29.465 7.72 0.819 2.442546844 alpha type-4

B, Upregulated differentially expressed proteins (37 in total). Molecul Unique ar weight Abundance ratio: Score Sequest Accession Description Coverage Peptides PSMs Peptides AAs (kDa) calc. pI Severe/control HT P0C0L5 Complement C4-B 66.800459 89 1289 1 1744 192.631 7.27 1.249 4859.406727 P01031 Complement C5 44.988067 66 254 66 1676 188.186 6.52 1.241 804.1478994 P02675 Fibrinogen beta chain 71.283096 28 168 28 491 55.892 8.27 1.35 564.475502 Immunoglobulin heavy constant gamma 4 A0A286YFJ8 (Fragment) 49.494949 14 371 6 396 43.804 6.24 1.43 1384.943221 Q08380 Galectin-3-binding protein 44.273504 22 188 22 585 65.289 5.27 1.24 656.6998068 P02671 Fibrinogen alpha chain 32.101617 24 118 24 866 94.914 6.01 1.368 365.6363721 P18428 Lipopolysaccharide-binding protein 20.58212 8 14 8 481 53.35 6.7 1.452 58.35807347 P02679 Fibrinogen gamma chain 52.980132 22 105 14 453 51.479 5.62 1.394 307.4672016 V9GYM3 Apolipoprotein A-II 48.120301 7 104 7 133 14.905 8.27 1.338 382.2305138 Q96GW7 Brevican core protein 32.052689 21 54 20 911 99.056 4.64 1.219 142.861371 P05067 Amyloid-beta A4 protein 18.05195 11 29 10 770 86.888 4.82 1..362 107.6358273 A0M8Q6 Immunoglobulin lambda constant 7 62.264151 6 286 2 106 11.247 8.29 1.633 1252.272737 P69892 Hemoglobin subunit gamma-2 88.435374 12 64 1 147 16.116 7.2 1.305 196.0103188 C9JU00 Fibrinogen gamma chain (Fragment) 76.422764 9 43 1 123 13.979 7.2 1.562 121.569379 P21246 Pleiotrophin 45.833333 7 28 7 168 18.93 9.6 1.51 83.90634847 B0YIW2 Apolipoprotein C-III variant 1 29.059829 4 28 4 117 12.807 8.18 1.282 96.72932458 P02654 Apolipoprotein C-I 32.53012 4 26 4 83 9.326 8.47 1.453 72.02493954 P02741 C-reactive protein 27.67857 7 39 7 224 25.023 5.63 1.217 117.7326272 P01817 Immunoglobulin heavy variable 2-5 12.605042 1 8 1 119 13.223 8.29 1.926 21.83701611 A0A096LPE2 SAA2-SAA4 readthrough 24.519231 5 13 3 208 23.338 8.98 1.214 38.32234967 P19652 Alpha-1-acid glycoprotein 2 21.890547 4 6 2 201 23.588 5.11 1.3 14.83352566 Immunoglobulin heavy constant alpha 1 A0A286YEY1 (Fragment) 16.834171 5 6 5 398 42.821 5.64 1.551 19.30940413 A0A0B4J1V2 Immunoglobulin heavy variable 2-26 17.647059 2 7 2 119 13.174 8.29 1.305 6.610331297 C1QTNF3-AMACR readthrough (NMD E9PGA6 candidate) SV=1 7.0422535 2 4 2 284 31.055 8.5 1.276 11.53779173 P01706 Immunoglobulin lambda variable 2-11 6.7226891 1 7 1 119 12.636 7.24 1.722 20.59473085 Q9ULF5 Zinc transporter ZIP10 1.6847172 1 1 1 831 94.073 6.76 1.268 3.784619093 P59665 Neutrophil defensin 1 19.148936 2 5 2 94 10.194 6.99 1.541 3.948067188 Q96EE4 Coiled-coil domain-containing protein 126 8.5714286 1 1 1 140 15.658 9.88 1.543 2.30135417 P02788 Lactotransferrin 1.6901408 1 1 1 710 78.132 8.12 1.588 2.225054979 P07492 Gastrin-releasing peptide 6.0810811 1 2 1 148 16.203 10.2 1.241 5.368754387 Q2KHR2 DNA-binding protein RFX7 0.9537784 1 2 1 1363 146.804 6.76 1.407 6.537794352 Q9NSB4 Keratin, type II cuticular Hb2 1.9493177 1 2 1 513 56.616 6.74 1.693 2.600922346 Immunoglobulin heavy variable 7-81 (non- A0A0B4J1V7 functional) (Fragment) 5.982906 1 1 1 117 12.909 7.11 1.201 2.589070559 E9PQD6 Serum amyloid A protein 35.2459 3 3 1 122 13.538 6.79 1.252 13.35751843 A0A0A0MT69 Immunoglobulin kappa joining 4 (Fragment) 66.666667 1 2 1 12 1.249 8.84 1.239 4.883342981 Q14533 Keratin, type II cuticular Hb1 1.5841584 1 2 1 505 54.893 5.47 1.698 3.43687953 Q92932 Receptor-type tyrosine-protein phosphatase N2 0.9852217 1 1 1 1015 111.202 5.83 1.203 2.087712526

Table SIV. A total of 194 differentially expressed proteins were identified by tandem mass spectrometry in the microvesicles/exosomes between moderate group and control group. A, Downregulated differentially expressed proteins (102 in total) Molecular Abundance Unique weight ratio: Score Sequest Accession Description Coverage Peptides PSMs Peptides AAs (kDa) calc. pI Moderate/control HT P02751 Fibronectin 56.03521 87 960 87 2386 262.46 5.71 0.805 3458.332983 Q12860 Contactin-1 56.87623 46 242 46 1018 113.249 5.9 0.747 816.1462975 P23142 Fibulin-1 57.32575 26 297 10 703 77.162 5.22 0.812 1110.052139 O00533 Neural cell adhesion molecule L1-like protein 42.88079 38 220 37 1208 134.987 5.76 0.789 804.1383946 B1AHL2 Fibulin-1 45.21498 22 313 6 721 78.277 5.39 0.738 1163.650674 P10643 Complement component C7 50.05931 29 156 29 843 93.457 6.48 0.712 573.7836608 B4E1Z4 cDNA FLJ55673, highly similar to Complement factor B 39.9684 46 160 29 1266 140.853 7.18 0.612 494.6025889 P01860 Immunoglobulin heavy constant gamma 3 61.00796 20 778 8 377 41.26 7.9 0.814 2633.157825 Q92823 Neuronal cell adhesion molecule 37.88344 35 146 35 1304 143.8 5.66 0.798 513.597772 P13645 Keratin, type I cytoskeletal 10 62.84247 32 125 29 584 58.792 5.21 0.767 416.226961 Q7Z7M0 Multiple epidermal growth factor-like domains protein 8 20.0703 40 121 40 2845 302.901 6.87 0.785 432.9133862 E7ERL8 Neurexin-1-beta 36.09821 39 126 28 1507 165.341 5.96 0.802 392.0663251 P06727 Apolipoprotein A-IV 75.75758 31 154 31 396 45.371 5.38 0.481 511.2329108 Q08380 Galectin-3-binding protein 44.2735 22 188 22 585 65.289 5.27 0.777 656.6998068 P04264 Keratin, type II cytoskeletal 1 43.47826 27 137 24 644 65.999 8.12 0.737 416.9153267 Ectonucleotide pyrophosphatase/phosphodiesterase E7EUF1 family member 2 35.181 26 116 26 884 101.488 7.53 0.804 414.4653013 P10909 Clusterin 37.86192 19 259 19 449 52.461 6.27 0.728 816.842995 P51693 Amyloid-like protein 1 28.61538 18 106 18 650 72.131 5.8 0.746 398.4112236 P01034 Cystatin-C 62.32877 8 103 8 146 15.789 8.75 0.764 433.4969542 P23468 Receptor-type tyrosine-protein phosphatase delta 19.66527 27 61 2 1912 214.625 6.57 0.749 204.8723233 P35908 Keratin, type II cytoskeletal 2 epidermal 51.3302 28 89 20 639 65.393 8 0.733 274.1373594 P35527 Keratin, type I cytoskeletal 9 39.9679 21 74 20 623 62.027 5.24 0.81 218.3285863 P11047 Laminin subunit gamma-1 21.44189 31 53 31 1609 177.489 5.12 0.79 167.0971448 P32004 Neural cell adhesion molecule L1 28.00318 31 58 30 1257 139.915 6.24 0.816 165.0750264 WAP, Kazal, immunoglobulin, Kunitz and NTR domain- Q8TEU8 containing protein 2 33.50694 15 41 15 576 63.898 6.21 0.767 130.4619564 P01019 Angiotensinogen 24.94845 9 29 9 485 53.121 6.32 0.761 112.7987204 C9JF17 Apolipoprotein D (Fragment) 33.48837 8 77 8 215 24.142 5.6 0.763 243.5303714 P05060 Secretogranin-1 18.75923 12 42 12 677 78.229 5.07 0.43 122.1391906 Q8WXD2 Secretogranin-3 40.81197 18 35 18 468 52.973 5.03 0.818 104.849102 P05546 Heparin cofactor 2 28.65731 13 38 13 499 57.034 6.9 0.703 89.73312998 Q92520 Protein FAM3C 46.25551 8 26 8 227 24.665 8.29 0.811 80.54141569 P41222 Prostaglandin-H2 D-isomerase 24.73684 4 36 4 190 21.015 7.8 0.792 129.7730234 F6SYF8 Dickkopf-related protein 3 30.21978 8 24 8 364 39.924 4.7 0.809 89.94954038 P02538 Keratin, type II cytoskeletal 6A 21.63121 12 32 3 564 60.008 8 0.675 92.53173935 C9JV77 Alpha-2-HS-glycoprotein 26.08696 8 22 8 368 39.387 5.72 0.701 76.79577923 P10645 Chromogranin-A 33.69803 10 21 10 457 50.658 4.6 0.827 77.65168238 P13647 Keratin, type II cytoskeletal 5 22.37288 13 28 5 590 62.34 7.74 0.805 79.18268931 P69905 Hemoglobin subunit alpha 50.70423 5 36 5 142 15.248 8.68 0.564 121.9940966 Q9UHG2 ProSAAS 25 5 29 5 260 27.356 6.62 0.797 105.5507272 O15240 Neurosecretory protein VGF 18.53659 9 24 9 615 67.218 4.78 0.822 88.6339159 Q9Y279 V-set and immunoglobulin domain-containing protein 4 28.82206 8 21 8 399 43.959 6.35 0.638 61.2986939 P01011 Alpha-1-antichymotrypsin 23.40426 8 18 8 423 47.621 5.52 0.809 65.44287133 P68871 Hemoglobin subunit beta 68.02721 8 29 7 147 15.988 7.28 0.583 84.50491452 P10412 Histone H1.4 28.76712 8 17 3 219 21.852 11.0 0.809 51.11493194 A0A0J9YXX1 Immunoglobulin heavy variable 5-10-1 26.49573 3 17 1 117 12.764 8.28 0.229 53.36616898 P07195 L-lactate dehydrogenase B chain 28.14371 8 10 7 334 36.615 6.05 0.816 34.73956013 P06702 Protein S100-A9 55.26316 5 16 5 114 13.234 6.13 0.512 46.12688518 P06276 Cholinesterase 13.62126 7 11 7 602 68.374 7.42 0.787 31.51544464 A0A087WXW9 Collagen alpha-1(V) chain 4.733406 8 11 7 1838 183.54 5.07 0.791 32.53059745 P23471 Receptor-type tyrosine-protein phosphatase zeta 3.36933 7 9 7 2315 254.429 4.88 0.777 28.14834929 P17900 Ganglioside GM2 activator 40.93264 5 10 5 193 20.825 5.31 0.767 33.73345375 P00338 L-lactate dehydrogenase A chain 24.39759 8 13 7 332 36.665 8.27 0.799 36.05286312 Q15904 V-type proton ATPase subunit S1 9.148936 3 4 3 470 51.993 6.14 0.791 15.82723546 P19021 Peptidyl-glycine alpha-amidating monooxygenase 7.29702 7 10 7 973 108.263 6.42 0.78 22.97336459 E9PQD6 Serum amyloid A protein 35.2459 3 3 1 122 13.538 6.79 0.799 13.35751843 P31151 Protein S100-A7 33.66337 3 6 3 101 11.464 6.77 0.486 19.76926899 P01699 Immunoglobulin lambda variable 1-44 38.46154 2 7 1 117 12.194 5.17 0.816 18.83399343 O94772 Lymphocyte antigen 6H 22.14286 3 6 3 140 14.659 7.25 0.719 14.21915698 A0A0C4DH43 Immunoglobulin heavy variable 2-70D 24.36975 2 6 1 119 13.304 8.29 0.171 17.26096582 Q16849 Receptor-type tyrosine-protein phosphatase-like N 3.064351 2 3 2 979 105.781 7.11 0.762 10.44954824 P61278 Somatostatin 16.37931 2 9 2 116 12.727 5.52 0.689 27.66441822 A0A0B4J1Y8 Immunoglobulin lambda variable 9-49 16.26016 2 4 2 123 13.016 7.28 0.566 11.32931447 Q06481 Amyloid-like protein 2 3.145478 2 3 1 763 86.9 4.79 0.479 8.72531271 Q9BYH1 Seizure 6-like protein 4.394531 3 4 3 1024 111.711 4.78 0.81 11.3955934 Calcium/calmodulin-dependent protein kinase type II Q9UQM7 subunit alpha 5.230126 1 2 1 478 54.054 7.08 0.761 9.663061619 P08758 Annexin A5 9.6875 2 2 2 320 35.914 5.05 0.724 7.304258108 P02743 Serum amyloid P-component 22.86996 5 8 5 223 25.371 6.54 0.775 18.65017509 Immunoglobulin heavy variable 1/OR15-1 (non- A0A075B7D0 functional) (Fragment) 27.35043 3 22 2 117 13.003 9.13 0.664 53.07422614 A0A075B6I0 Immunoglobulin lambda variable 8-61 14.7541 2 6 2 122 12.806 4.55 0.694 18.62005115 H7C4X7 Neuroendocrine protein 7B2 (Fragment) 8.333333 1 2 1 216 24.039 6.52 0.807 7.56017375 Q14118 Dystroglycan 4.134078 3 4 3 895 97.381 8.56 0.737 12.05706 A0A1X7SBT7 Neuronal pentraxin receptor 4.6 2 4 2 500 52.795 6.21 0.694 11.35587358 P05109 Protein S100-A8 31.1828 3 5 3 93 10.828 7.03 0.684 10.32500505 Immunoglobulin heavy variable 4/OR15-8 (non- A0A075B7B6 functional) (Fragment) 17.09402 3 9 2 117 12.991 9.6 0.602 18.60829031 Q10471 Polypeptide N-acetylgalactosaminyltransferase 2 4.028021 2 3 2 571 64.691 8.35 0.82 8.085972548 P23284 Peptidyl-prolyl cis-trans isomerase B 6.018519 1 1 1 216 23.728 9.41 0.825 3.232524395 Calcium/calmodulin-dependent protein kinase type II Q13554 subunit beta 5.105105 2 2 2 666 72.632 7.27 0.762 5.976769209 Q6EMK4 Vasorin 2.377415 1 1 1 673 71.668 7.39 0.81 3.11607933 Q99983 Osteomodulin 4.275534 2 2 2 421 49.46 5.59 0.773 3.411369085 P81605 Dermcidin 10 1 1 1 110 11.277 6.54 0.722 2.896159649 Q16568 Cocaine- and amphetamine-regulated transcript protein 9.482759 1 1 1 116 12.821 8.25 0.549 2.36256671 Q9UJC3 Protein Hook homolog 1 2.60989 1 3 1 728 84.595 5.15 0.696 8.252165079 O75093 Slit homolog 1 protein 0.586701 1 4 1 1534 167.816 6.57 0.763 11.01824176 P80723 Brain acid soluble protein 1 9.251101 1 1 1 227 22.68 4.63 0.732 2.931092501 B5MCX6 V-set and transmembrane domain-containing protein 2A 3.236246 1 1 1 309 33.834 9.32 0.785 0 Q2KHR2 DNA-binding protein RFX7 0.953778 1 2 1 1363 146.804 6.76 0.667 6.537794352 P15328 Folate receptor alpha 4.280156 1 1 1 257 29.799 7.97 0.707 2.122770786 Q04721 Neurogenic locus notch homolog protein 2 0.445164 1 1 1 2471 265.226 5.14 0.772 2.447184801 A0A0C4DH39 Immunoglobulin heavy variable 1-58 5.982906 1 3 1 117 12.996 9.25 0.782 4.782530069 O14604 Thymosin beta-4, Y-chromosomal 15.90909 1 1 1 44 5.009 5.36 0.749 2.542981863 Q9P2E7 Protocadherin-10 1.153846 1 1 1 1040 112.866 4.87 0.771 0 A0A087WSX0 Immunoglobulin lambda variable 5-45 11.38211 1 1 1 123 13.153 7.2 0.648 2.556994438 P28300 Protein-lysine 6-oxidase 4.556355 1 1 1 417 46.915 8.09 0.791 2.902485847 Q92858 Protein atonal homolog 1 3.107345 1 1 1 354 38.137 8.13 0.747 2.284917593 A0A087WY08 Thrombospondin type-1 domain-containing protein 7A 0.4828 1 1 1 1657 185.317 7.43 0.788 0 O75493 Carbonic anhydrase-related protein 11 3.353659 1 2 1 328 36.216 9.74 0.81 2.672258139 H7BY55 Complement decay-accelerating factor 1.454545 1 1 1 550 58.873 8.78 0.691 0 Q9NR99 Matrix-remodeling-associated protein 5 0.318246 1 1 1 2828 311.955 8.32 0.812 2.151638746 P54803 Galactocerebrosidase 1.167883 1 1 1 685 77.015 6.64 0.746 2.248755932 Q8WX77 Insulin-like growth factor-binding protein-like 1 3.597122 1 1 1 278 28.987 7.93 0.752 2.342568874 P29508 Serpin B3 1.794872 1 1 1 390 44.537 6.81 0.611 0 A8K070 COP9 signalosome complex subunit 1 1.140684 1 1 1 526 58.885 6.32 0.626 2.348926544

B, Upregulated differentially expressed proteins (92 in total) Molecular Abundance Unique weight ratio: Accession Description Coverage Peptides PSMs Peptides AAs (kDa) calc. pI Moderate/control Score Sequest HT P0C0L5 Complement C4-B 66.800459 89 1289 1 1744 192.631 7.27 2.106 4859.406727 Q9Y6R7 IgGFc-binding protein 27.715079 68 305 68 5405 571.639 5.34 1.527 981.3557811 Immunoglobulin heavy constant gamma 1 A0A0A0MS08 (Fragment) 55.639098 23 1247 12 399 43.884 6.96 1.206 4833.498744 P12111 Collagen alpha-3(VI) chain 28.076802 67 142 1 3177 343.457 6.68 1.317 483.426379 P02647 Apolipoprotein A-I 77.153558 24 385 24 267 30.759 5.76 1.315 1253.797316 P02675 Fibrinogen beta chain 71.283096 28 168 28 491 55.892 8.27 1.531 564.475502 Immunoglobulin heavy constant gamma 2 A0A286YEY4 (Fragment) 54.43038 17 719 8 395 43.778 6.52 1.565 2565.892901 Immunoglobulin heavy constant gamma 4 A0A286YFJ8 (Fragment) 49.494949 14 371 6 396 43.804 6.24 1.412 1384.943221 P01834 Immunoglobulin kappa constant 80.373832 6 655 6 107 11.758 6.52 1.299 2588.88807 P02671 Fibrinogen alpha chain 32.101617 24 118 24 866 94.914 6.01 1.342 365.6363721 P02679 Fibrinogen gamma chain 52.980132 22 105 14 453 51.479 5.62 1.478 307.4672016 V9GYM3 Apolipoprotein A-II 48.120301 7 104 7 133 14.905 8.27 1.219 382.2305138 P60709 Actin, cytoplasmic 1 37.066667 10 39 4 375 41.71 5.48 1.239 141.0285643 P69892 Hemoglobin subunit gamma-2 88.435374 12 64 1 147 16.116 7.2 2.018 196.0103188 A0A2R8Y7X9 Uncharacterized protein 86.904762 12 64 1 168 18.409 6.96 1.303 200.0579996 P05067 Amyloid-beta A4 protein 18.05195 11 29 10 770 86.888 4.82 1.274 107.6358273 P02746 Complement C1q subcomponent subunit B 41.501976 7 51 7 253 26.704 8.63 1.21 182.5711771 C9JU00 Fibrinogen gamma chain (Fragment) 76.422764 9 43 1 123 13.979 7.2 1.475 121.569379 A0A0C4DH31 Immunoglobulin heavy variable 1-18 42.735043 4 52 2 117 12.812 8.84 1.252 124.0538703 P01780 Immunoglobulin heavy variable 3-7 32.478632 4 76 2 117 12.934 6.57 1.321 193.2849478 A0A0C4DH41 Immunoglobulin heavy variable 4-61 44.067797 4 44 2 118 13.058 9.29 1.249 121.7412282 P01762 Immunoglobulin heavy variable 3-11 53.846154 4 58 2 117 12.9 8.6 1.291 139.7722524 P02747 Complement C1q subcomponent subunit C 21.22449 4 31 4 245 25.757 8.41 1.219 112.9564657 P10451 Osteopontin 13.375796 3 34 3 314 35.401 4.58 1.338 127.6464496 P01763 Immunoglobulin heavy variable 3-48 35.042735 3 57 1 117 12.804 5.36 1.286 138.5215894 P04433 Immunoglobulin kappa variable 3-11 58.26087 4 28 3 115 12.567 4.96 1.32 72.31677985 P06312 Immunoglobulin kappa variable 4-1 34.710744 4 46 4 121 13.372 5.25 1.287 111.6955808 A0A0C4DH73 Immunoglobulin kappa variable 1-12 29.059829 2 46 1 117 12.637 8.31 1.233 159.1169224 P00488 Coagulation factor XIII A chain 16.530055 9 18 9 732 83.215 6.09 1.257 53.4234997 A0A0C4DH69 Immunoglobulin kappa variable 1-9 29.059829 2 24 1 117 12.706 8.29 1.36 102.5505395 P31146 Coronin-1A 23.427332 9 11 9 461 50.994 6.68 1.263 37.99821258 P02741 C-reactive protein 27.67857 7 39 7 224 25.023 5.63 1.235 117.7326272 P02792 Ferritin light chain 28.571429 4 18 4 175 20.007 5.78 2.368 47.40906429 A0A0B4J1X8 Immunoglobulin heavy variable 3-43 34.745763 3 26 2 118 13.068 5.41 1.211 55.60068369 P62805 Histone H4 51.456311 6 18 6 103 11.36 11.36 1.417 42.72476315 A0A087X0Q4 Immunoglobulin kappa variable 2-40 50 3 19 3 104 11.427 4.49 1.441 67.15511155 A0A075B6S5 Immunoglobulin kappa variable 1-27 29.059829 2 23 1 117 12.703 8.29 1.59 99.54478717 P02654 Apolipoprotein C-I 32.53012 4 26 4 83 9.326 8.47 1.294 72.02493954 P07900 Heat shock protein HSP 90-alpha 13.114754 9 15 3 732 84.607 5.02 1.523 44.34405565 P01817 Immunoglobulin heavy variable 2-5 12.605042 1 8 1 119 13.223 8.29 1.775 21.83701611 P35579 Myosin-9 4.5408163 6 6 6 1960 226.392 5.6 1.235 18.66729665 P08238 Heat shock protein HSP 90-beta 11.878453 8 13 1 724 83.212 5.03 1.428 37.95699954 U3KQK0 Histone H2B 24.698795 4 11 4 166 18.792 10.54 1.447 29.86686897 P18428 Lipopolysaccharide-binding protein 20.58212 8 14 8 481 53.35 6.7 1.367 58.35807347 Q9Y490 Talin-1 3.227076 4 4 4 2541 269.599 6.07 1.379 13.91558695 Immunoglobulin heavy variable 3-35 (non- A0A0C4DH35 functional) (Fragment) 16.239316 2 10 2 117 12.802 7.88 1.222 24.93146586 Immunoglobulin kappa variable 3-7 (non- A0A075B6H7 functional) (Fragment) 42.241379 3 24 3 116 12.775 5.25 1.287 53.83410645 Q06033 Inter-alpha-trypsin inhibitor heavy chain H3 7.6404494 5 5 5 890 99.787 5.74 1.283 17.40087748 Immunoglobulin kappa variable 2D-24 (non- A0A075B6R9 functional) (Fragment) 16.666667 2 8 2 120 13.071 8.87 1.373 24.2537272 A0A0U1RRH7 Histone H2A 20.588235 3 6 3 170 18.541 11.52 1.563 25.5635848 P04430 Immunoglobulin kappa variable 1-16 29.059829 2 4 2 117 12.61 8.16 1.405 16.53339887 A0A0C4DH34 Immunoglobulin heavy variable 4-28 44.444444 4 15 2 117 13.116 9.29 1.582 32.19099617 P04211 Immunoglobulin lambda variable 7-43 15.384615 2 7 1 117 12.443 7.03 1.996 19.63640356 P62258 14-3-3 protein epsilon 14.509804 3 3 1 255 29.155 4.74 1.31 10.48452115 A0A0G2JRQ6 Uncharacterized protein (Fragment) 13.675214 2 18 2 117 12.74 8.29 2.585 37.33334506 P01031 Complement C5 44.98807 66 254 66 1676 188.186 6.52 1.224 804.1478994 P11142 Heat shock cognate 71 kDa protein 5.7275542 3 6 1 646 70.854 5.52 1.256 16.45200515 C9JIZ6 Prosaposin 6.8311195 2 4 2 527 58.402 5.17 1.284 11.90637851 Deoxynucleoside triphosphate Q9Y3Z3 triphosphohydrolase SAMHD1 6.8690096 3 3 3 626 72.155 7.14 1.362 5.907426596 A0A0B4J1U7 Immunoglobulin heavy variable 6-1 21.487603 3 19 3 121 13.473 9.2 1.874 32.06293344 P02794 Ferritin heavy chain 14.20765 2 2 2 183 21.212 5.55 1.455 6.528439045 A0A075B6I9 Immunoglobulin lambda variable 7-46 15.384615 2 6 1 117 12.46 7.2 1.26 17.20948243 P61160 Actin-related protein 2 6.0913706 2 2 2 394 44.732 6.74 1.21 6.874537468 K7ES00 Histone H3.3 (Fragment) 15.231788 3 5 3 151 16.611 11.84 1.293 11.93146896 P01602 Immunoglobulin kappa variable 1-5 24.786325 2 6 2 117 12.773 8.28 1.259 14.60442519 Q9NZK5 Adenosine deaminase 2 4.109589 2 3 2 511 58.895 7.91 1.295 7.421756506 Q08431 Lactadherin 6.9767442 2 2 2 387 43.095 8.15 1.234 6.527766228 Q15084 Protein disulfide-isomerase A6 3.1818182 1 1 1 440 48.091 5.08 1.238 4.055136681 A0A075B6J9 Immunoglobulin lambda variable 2-18 24.576271 2 2 2 118 12.404 4.82 1.387 6.415935516 P55072 Transitional endoplasmic reticulum ATPase 2.1091811 1 1 1 806 89.266 5.26 1.675 3.182904959 P13796 Plastin-2 2.3923445 1 1 1 627 70.244 5.43 1.221 3.501815796 P46940 Ras GTPase-activating-like protein IQGAP1 1.1466506 1 1 1 1657 189.134 6.48 1.321 3.867439032 P28066 Proteasome subunit alpha type-5 4.9792531 1 1 1 241 26.394 4.79 1.416 3.646942854 P59665 Neutrophil defensin 1 19.148936 2 5 2 94 10.194 6.99 1.645 3.948067188 P05387 60S acidic ribosomal protein P2 10.434783 1 1 1 115 11.658 4.54 1.26 2.487269163 Immunoglobulin kappa variable 6D-41 (non- A0A0C4DH26 functional) (Fragment) 10.434783 1 2 1 115 12.562 7.12 1.817 4.417459726 P61978 Heterogeneous nuclear ribonucleoprotein K 2.5917927 1 2 1 463 50.944 5.54 1.367 5.50231719 P26641 Elongation factor 1-gamma 2.2883295 1 1 1 437 50.087 6.67 1.844 2.721371174 Q96EE4 Coiled-coil domain-containing protein 126 8.5714286 1 1 1 140 15.658 9.88 2.274 2.30135417 P07384 Calpain-1 catalytic subunit 2.5210084 1 1 1 714 81.838 5.67 1.215 3.453569174 P02788 Lactotransferrin 1.6901408 1 1 1 710 78.132 8.12 1.521 2.225054979 P06307 Cholecystokinin 8.6956522 1 2 1 115 12.661 9.01 1.371 4.437003136 Q00973 Beta-1,4 N-acetylgalactosaminyltransferase 1 2.8142589 1 1 1 533 58.846 8.69 1.215 2.988195181 O14793 Growth/differentiation factor 8 2.6666667 1 1 1 375 42.722 6.76 1.21 2.456470966 Phosphatidylinositol 3,4,5-trisphosphate 5- Q92835 phosphatase 1 0.58873 1 3 1 1189 133.209 7.59 1.408 4.833375931 O43866 CD5 antigen-like 2.5936599 1 1 1 347 38.063 5.47 1.495 2.150546312 A0A087X1Z3 Proteasome activator complex subunit 2 5.1181102 1 1 1 254 29.108 6.71 1.352 3.986524578 Q96RT7 Gamma-tubulin complex component 6 0.6597031 1 3 1 1819 200.372 6.32 2.28 2.810472488 Q86UB9 Transmembrane protein 135 3.4934498 1 1 1 458 52.256 9.45 1.329 4.7654389665 P62191 26S proteasome regulatory subunit 4 2.0454545 1 1 1 440 49.154 6.21 1.35 2.048808813 P62993 Growth factor receptor-bound protein 2 6.4516129 1 1 1 217 25.19 6.32 1.258 3.985645322 E9PQD6 Serum amyloid A protein 35.2459 3 3 1 122 13.538 6.79 1.324 13.35751843