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Vascular Supply of the Human Spiral Ganglion: Novel Three
www.nature.com/scientificreports Corrected: Publisher Correction OPEN Vascular Supply of the Human Spiral Ganglion: Novel Three- Dimensional Analysis Using Synchrotron Phase-Contrast Imaging and Histology Xueshuang Mei1,2*, Rudolf Glueckert3, Annelies Schrott-Fischer3, Hao Li1, Hanif M. Ladak4,6, Sumit K. Agrawal5,6 & Helge Rask-Andersen1,6* Human spiral ganglion (HSG) cell bodies located in the bony cochlea depend on a rich vascular supply to maintain excitability. These neurons are targeted by cochlear implantation (CI) to treat deafness, and their viability is critical to ensure successful clinical outcomes. The blood supply of the HSG is difcult to study due to its helical structure and encasement in hard bone. The objective of this study was to present the frst three-dimensional (3D) reconstruction and analysis of the HSG blood supply using synchrotron radiation phase-contrast imaging (SR-PCI) in combination with histological analyses of archival human cochlear sections. Twenty-six human temporal bones underwent SR-PCI. Data were processed using volume-rendering software, and a representative three-dimensional (3D) model was created to allow visualization of the vascular anatomy. Histologic analysis was used to verify the segmentations. Results revealed that the HSG is supplied by radial vascular twigs which are separate from the rest of the inner ear and encased in bone. Unlike with most organs, the arteries and veins in the human cochlea do not follow the same conduits. There is a dual venous outfow and a modiolar arterial supply. This organization may explain why the HSG may endure even in cases of advanced cochlear pathology. Human inner ear function relies on microcirculation derived from vessels in the internal auditory canal (IAC). -
Fallen in a Dead Ear: Intralabyrinthine Preservation of Stapes in Fossil Artiodactyls Maeva Orliac, Guillaume Billet
Fallen in a dead ear: intralabyrinthine preservation of stapes in fossil artiodactyls Maeva Orliac, Guillaume Billet To cite this version: Maeva Orliac, Guillaume Billet. Fallen in a dead ear: intralabyrinthine preservation of stapes in fossil artiodactyls. Palaeovertebrata, 2016, 40 (1), 10.18563/pv.40.1.e3. hal-01897786 HAL Id: hal-01897786 https://hal.archives-ouvertes.fr/hal-01897786 Submitted on 17 Oct 2018 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/297725060 Fallen in a dead ear: intralabyrinthine preservation of stapes in fossil artiodactyls Article · March 2016 DOI: 10.18563/pv.40.1.e3 CITATIONS READS 2 254 2 authors: Maeva Orliac Guillaume Billet Université de Montpellier Muséum National d'Histoire Naturelle 76 PUBLICATIONS 745 CITATIONS 103 PUBLICATIONS 862 CITATIONS SEE PROFILE SEE PROFILE Some of the authors of this publication are also working on these related projects: The ear region of Artiodactyla View project Origin, evolution, and dynamics of Amazonian-Andean ecosystems View project All content following this page was uploaded by Maeva Orliac on 14 March 2016. -
CONGENITAL MALFORMATIONS of the INNER EAR Malformaciones Congénitas Del Oído Interno
topic review CONGENITAL MALFORMATIONS OF THE INNER EAR Malformaciones congénitas del oído interno. Revisión de tema Laura Vanessa Ramírez Pedroza1 Hernán Darío Cano Riaño2 Federico Guillermo Lubinus Badillo2 Summary Key words (MeSH) There are a great variety of congenital malformations that can affect the inner ear, Ear with a diversity of physiopathologies, involved altered structures and age of symptom Ear, inner onset. Therefore, it is important to know and identify these alterations opportunely Hearing loss Vestibule, labyrinth to lower the risks of all the complications, being of great importance, among others, Cochlea the alterations in language development and social interactions. Magnetic resonance imaging Resumen Existe una gran variedad de malformaciones congénitas que pueden afectar al Palabras clave (DeCS) oído interno, con distintas fisiopatologías, diferentes estructuras alteradas y edad Oído de aparición de los síntomas. Por lo anterior, es necesario conocer e identificar Oído interno dichas alteraciones, con el fin de actuar oportunamente y reducir el riesgo de las Pérdida auditiva Vestíbulo del laberinto complicaciones, entre otras —de gran importancia— las alteraciones en el área del Cóclea lenguaje y en el ámbito social. Imagen por resonancia magnética 1. Epidemiology • Hyperbilirubinemia Ear malformations occur in 1 in 10,000 or 20,000 • Respiratory distress from meconium aspiration cases (1). One in every 1,000 children has some degree • Craniofacial alterations (3) of sensorineural hearing impairment, with an average • Mechanical ventilation for more than five days age at diagnosis of 4.9 years. The prevalence of hearing • TORCH Syndrome (4) impairment in newborns with risk factors has been determined to be 9.52% (2). -
Cochlear Partition Anatomy and Motion in Humans Differ from The
Cochlear partition anatomy and motion in humans differ from the classic view of mammals Stefan Raufera,b,1, John J. Guinan Jra,b,c, and Hideko Heidi Nakajimaa,b,c aEaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, MA 02114; bSpeech and Hearing Bioscience and Technology Program, Harvard University, Cambridge, MA 02138; and cDepartment of Otolaryngology, Harvard Medical School, Boston, MA 02115 Edited by Christopher A. Shera, University of Southern California, Los Angeles, CA, and accepted by Editorial Board Member Thomas D. Albright June 6, 2019 (received for review January 16, 2019) Mammals detect sound through mechanosensitive cells of the assume there is no OSL motion (10–13). Additionally, the attach- cochlear organ of Corti that rest on the basilar membrane (BM). ment of the OSL to the BM and the attachment of the TM to Motions of the BM and organ of Corti have been studied at the spiral limbus (which sits above the OSL) are also consid- the cochlear base in various laboratory animals, and the assump- ered stationary. In contrast to this view, there have been reports tion has been that the cochleas of all mammals work similarly. of sound-induced OSL movement, but these reports have been In the classic view, the BM attaches to a stationary osseous spi- largely ignored in overviews of cochlear mechanics and the for- ral lamina (OSL), the tectorial membrane (TM) attaches to the mation of cochlear models (10–13). Von B´ek´esy (14), using static limbus above the stationary OSL, and the BM is the major mov- pressure, found that the CP “bent like an elastic rod that was free ing element, with a peak displacement near its center. -
ANATOMY of EAR Basic Ear Anatomy
ANATOMY OF EAR Basic Ear Anatomy • Expected outcomes • To understand the hearing mechanism • To be able to identify the structures of the ear Development of Ear 1. Pinna develops from 1st & 2nd Branchial arch (Hillocks of His). Starts at 6 Weeks & is complete by 20 weeks. 2. E.A.M. develops from dorsal end of 1st branchial arch starting at 6-8 weeks and is complete by 28 weeks. 3. Middle Ear development —Malleus & Incus develop between 6-8 weeks from 1st & 2nd branchial arch. Branchial arches & Development of Ear Dev. contd---- • T.M at 28 weeks from all 3 germinal layers . • Foot plate of stapes develops from otic capsule b/w 6- 8 weeks. • Inner ear develops from otic capsule starting at 5 weeks & is complete by 25 weeks. • Development of external/middle/inner ear is independent of each other. Development of ear External Ear • It consists of - Pinna and External auditory meatus. Pinna • It is made up of fibro elastic cartilage covered by skin and connected to the surrounding parts by ligaments and muscles. • Various landmarks on the pinna are helix, antihelix, lobule, tragus, concha, scaphoid fossa and triangular fossa • Pinna has two surfaces i.e. medial or cranial surface and a lateral surface . • Cymba concha lies between crus helix and crus antihelix. It is an important landmark for mastoid antrum. Anatomy of external ear • Landmarks of pinna Anatomy of external ear • Bat-Ear is the most common congenital anomaly of pinna in which antihelix has not developed and excessive conchal cartilage is present. • Corrections of Pinna defects are done at 6 years of age. -
Organum Vestibulocochleare INTERNAL EAR MIDDLE EAR EXTERNAL EAR PETROSAL BONE- Eq EXTERNAL EAR AURICLE
EAR organum vestibulocochleare INTERNAL EAR MIDDLE EAR EXTERNAL EAR PETROSAL BONE- Eq EXTERNAL EAR AURICLE The external ear plays the role of an acoustic antenna: auricle the auricle (together with the head) collects and focuses sound waves, the ear canal act as a resonator. tympanic membrane anular cartilage meatus acusticus externus EXTERNAL EAR EXTERNAL EAR AURICLE scutiform cartilage Auricular muscles: -Dorsal -Ventral -Rostral -Caudal EXTERNAL EAR MEATUS ACUSTICUS EXTERNUS auricular cartilage vertical canal auditory ossicles horizontal cochlea canal auditory tube tympanic tympanic eardrum bulla cavity tympanic membrane MIDDLE EAR Auditory ossicles STAPES INCUS Tympanic cavity: (anvil) (stirrup) - epitympanium - mesotympanium - hypotympanium MALLEUS (hammer) auditory vestibular window- ossicles or oval window through which mechanical stimuli (transmitted by the auditory ossicles) enter the epitympanic internal ear for translation recess into nerve impulses auditory tube (Eustachian tube) cochlear window- or round window tympanic cavity bulla tympanica through which the vibration of the perilympha is absorbed MIDDLE EAR MIDDLE EAR GUTTURAL POUCH- Eq MIDDLE EAR AUDITORY OSSICLES head INCUS processus rostralis (stirrup) STAPES processus muscularis (anvil) manubrium short crus body MALLEUS (hammer) Two muscles of the ossicles: long crus m. tensor tympani- n. tensoris tympani ex. n. base mandibularis (footplate) m. stapedius- n. stapedius ex. n. facialis crus The muscles fix the bones and protect the cochlea crus against the harmful effects -
The Temporal Bone
Anatomic Moment The Temporal Bone Joel D. Swartz, David L. Daniels, H. Ric Harnsberger, Katherine A. Shaffer, and Leighton Mark Despite the advent of thin-section high-reso- the inner ear structures and the external lution computed tomography and, more re- environment. cently, unique magnetic resonance imaging se- Virtually all textbooks define the inner ear as quences with thin sections, T2 weighting, and a membranous labyrinth housed within an os- maximum-intensity projection techniques, seous labyrinth. The membranous labyrinth three-dimensional neuroanatomy of the tempo- contains endolymph, a fluid rich in potassium ral bone and related structures remains some- and low in sodium, similar to intracellular fluid. what of an enigma to many medical specialists, Interposed between the membranous labyrinth neuroradiologists included. Therefore, we are and the osseous labyrinth resides a supportive undertaking a series of anatomic moments in perilymphatic labyrinth. Perilymph is similar to the hope of solidifying the most important ana- cerebrospinal fluid and other extracellular tissue tomic concepts as they relate to this region. Our fluid. approach will be organized so as to consider the The osseous labyrinth consists of the bony temporal bone to represent the complex inter- edifice for the vestibule, semicircular canals, relationship of three systems: hearing, balance, cochlea, and vestibular aqueduct. The mem- and related neuroanatomic and neurovascular branous labyrinth consists of the utricle and structures. saccule (located within the vestibule), the semi- The ear originated in fish as a water motion circular ducts, the cochlear duct, and the en- detection system (1). The vestibular (balance) dolymphatic duct. The latter is a channel within mechanism becomes more complex as we the vestibular aqueduct with communications to scale the embryologic ladder and endolymph the utricle and saccule. -
Temporal Bone, Normal Anatomy, Computed Tomography/Histology
Temporal Bone Normal Anatomy Computed Tomography /Histology Correlation Otopathology Laboratory Department of Radiology Massachusetts Eye and Ear Eric F. Curtin Barbara J. Burgess Dianne D. Jones Jennifer T. O’Malley Hugh D. Curtin MD Otopathologylaboratory.org Facial nerve Malleus Incus Cochlea Lateral canal Oval Window Axial CT Red Arrow -Facial nerve VII Attic IAC Vest LSCC Red Arrow -Facial nerve VII M I M-Malleus I-Incus Vest Cochlea S-Stapes VII S Interscalar septum M M-Modiolus Interscalar septum M M-Modiolus Anterior epitympanic recess Cog Cochleariform process Cochlea Facial recess S-Stapes Pyramidal process S Sinus Tympani ME ME-middle ear RW-round window Cochlea RW Stapedius M Carotid TMJ plate Jugular plate Coronal CT FN 2 FN 1 Cochlea Carotid Malleus Tegmen Incus FN 2 Oval window Scutum Lateral Semicircular Canal Pyramidal process Round Window Jugular Facial Nerve Key image lateral canal facial nerve oval window .. Poschl CT Carotid Tensor tympani Eustachian tube VII1 IAC Basilar turn cochlea Apical turn cochlea Turn 2 cochlea VII1 VII2 Tensor tympani VII2 Jugular vein Tensor tympani Jugular vein Cochleariform process Superior SCC M M-malleus VII2 Oval W Round W Lateral canal Common crus TMJ Lateral SCC VII2 I S I –Incus S- Stapes Tegmen Vestibular aqueduct VII2 VII3 EAC Stenvers CT SSCC VII1 Carotid VII1 is separated from nerve to lateral canal by Bill’s bar Canal for nerve to lateral SCC VII VII1 Basilar turn cochlea LSCC SSCC VII3 Round window Styloid process Vestibule VII3 PSCC Common Crus IAC Axial CT Histology correlation Utricle Lateral Semicircular Canal Vestibule Vestibule Saccule Utricle Vestibule Saccule Utricle Vestibule Saccule Utricle Anterior Crus of the Stapes Carotid Tympanic Carotid plate membrane Middle Ear Jugular Jugular plate Coronal CT Histology correlation Saccule Otopathology Laboratory Department of Radiology Massachusetts Eye and Ear Otopathologylaboratory.org Eric F. -
Anatomic Moment
Anatomic Moment Hearing, I: The Cochlea David L. Daniels, Joel D. Swartz, H. Ric Harnsberger, John L. Ulmer, Katherine A. Shaffer, and Leighton Mark The purpose of the ear is to transform me- cochlear recess, which lies on the medial wall of chanical energy (sound) into electric energy. the vestibule (Fig 3). As these sound waves The external ear collects and directs the sound. enter the perilymph of the scala vestibuli, they The middle ear converts the sound to fluid mo- are transmitted through the vestibular mem- tion. The inner ear, specifically the cochlea, brane into the endolymph of the cochlear duct, transforms fluid motion into electric energy. causing displacement of the basilar membrane, The cochlea is a coiled structure consisting of which stimulates the hair cell receptors of the two and three quarter turns (Figs 1 and 2). If it organ of Corti (Figs 4–7) (4, 5). It is the move- were elongated, the cochlea would be approxi- ment of hair cells that generates the electric mately 30 mm in length. The fluid-filled spaces potentials that are converted into action poten- of the cochlea are comprised of three parallel tials in the auditory nerve fibers. The basilar canals: an outer scala vestibuli (ascending spi- membrane varies in width and tension from ral), an inner scala tympani (descending spi- base to apex. As a result, different portions of ral), and the central cochlear duct (scala media) the membrane respond to different auditory fre- (1–7). The scala vestibuli and scala tympani quencies (2, 5). These perilymphatic waves are contain perilymph, a substance similar in com- transmitted via the apex of the cochlea (helico- position to cerebrospinal fluid. -
The Nervous System: General and Special Senses
18 The Nervous System: General and Special Senses PowerPoint® Lecture Presentations prepared by Steven Bassett Southeast Community College Lincoln, Nebraska © 2012 Pearson Education, Inc. Introduction • Sensory information arrives at the CNS • Information is “picked up” by sensory receptors • Sensory receptors are the interface between the nervous system and the internal and external environment • General senses • Refers to temperature, pain, touch, pressure, vibration, and proprioception • Special senses • Refers to smell, taste, balance, hearing, and vision © 2012 Pearson Education, Inc. Receptors • Receptors and Receptive Fields • Free nerve endings are the simplest receptors • These respond to a variety of stimuli • Receptors of the retina (for example) are very specific and only respond to light • Receptive fields • Large receptive fields have receptors spread far apart, which makes it difficult to localize a stimulus • Small receptive fields have receptors close together, which makes it easy to localize a stimulus. © 2012 Pearson Education, Inc. Figure 18.1 Receptors and Receptive Fields Receptive Receptive field 1 field 2 Receptive fields © 2012 Pearson Education, Inc. Receptors • Interpretation of Sensory Information • Information is relayed from the receptor to a specific neuron in the CNS • The connection between a receptor and a neuron is called a labeled line • Each labeled line transmits its own specific sensation © 2012 Pearson Education, Inc. Interpretation of Sensory Information • Classification of Receptors • Tonic receptors -
ACTIVITY 5A STUDENT HANDOUT Glossary: Description and Function of Parts of the Human Ear the Three Functions of the Middle
ACTIVITY 5A STUDENT HANDOUT Glossary: Description and Function of Parts of the Human Ear EXTERNAL EAR AURICLE: the ear flap, ear lobe, or outer ear (pinna); collects sound waves and transmits them through the external acoustic meatus (auditory canal) to the tympanic membrane. EXTERNAL AUDITORY CANAL : an S-shaped structure about 2 cm in length, lined with numerous glands secreting a yellow, waxy substance, cerumen. CERUMEN: yellow, waxy substance; lubricates and protects the ear; “ear wax.” MIDDLE EAR TYMPANIC CAVITY middle: ear, tiny cavity in the temporal bone; holds the three auditory ossicles; has five openings (opening covered by the tympanic membrane), the opening of the auditory tube (eustachian tube) which connects the middle ear with the nasopharynx and through which outside air can enter; the opening into the mastoid cavity, the openings in to the inner ear (round and oval windows). TYMPANIC MEMBRANE: eardrum. AUDITORY OSSICLES: three tiny bones of middle ear, including malleus (hammer), incus (anvil), and stapes (stirrup). STAPEDIUS MUSCLE: attached to the stapes. TENSOR TYMPANI MUSCLE: attached to the handle of the malleus. EUSTACHIAN TUBE: connects middle ear with mouth to equalize pressure. The three functions of the Middle Ear 1. TRANSMIT ENERGY from sound vibrations in the air column of the external auditory meatus across the middle ear into the fluid contained within the cochlea (central hearing apparatus); bones of middle ear pick up the vibrations from the tympanicmembrane and transmit them across the middle ear to the oval window (the opening to the inner ear). 2. PROTECTIVE: reduces the amplitude of vibrations accompanying intense sounds of low frequency; contraction of the tensor tympani and the stapedius restricts the motion of the chain of ossicles and minimizes shock to the inner ear. -
Anatomy of the Ear
Anatomy of the Ear Lecture (10) ▪ Important ▪ Doctors Notes Please check our Editing File ▪ Notes/Extra explanation ه هذا العمل مب ين بشكل أسا يس عىل عمل دفعة 436 مع المراجعة { َوَم نْ يَ َت َو َ ّكْ عَ َلْ ا َّْلل فَهُ َوْ َحْ سْ ُ ُُْ} والتدقيق وإضافة المﻻحظات وﻻ يغ ين عن المصدر اﻷسا يس للمذاكرة Objectives By the end of the lecture the student should be able to: ✓ List the parts of the ear: External, Middle (tympanic cavity) and Internal (labyrinth). ✓ Describe the parts of the external ear: auricle and external auditory meatus. ✓ Identify the boundaries of the middle ear : roof, floor and four walls (anterior, posterior, medial and lateral). ✓ Define the contents of the tympanic cavity: I. Ear ossicles,: (malleus, incus and stapes) II. Muscles, (tensor tympani and stapedius). III. Nerves (branches of facial and glossopharyngeal). ✓ List the parts of the inner ear, bony part filled with perilymph (Cochlea, vestibule and semicircular canals), in which is suspended the membranous part that filled with endolymph). ✓ List the organs of hearing and equilibrium. External Ear 05:18 o It is formed of the auricle, & the external auditory meatus. o The Auricle has a characteristic shape and collects air vibrations reception of sound. o It consists of a thin plate of elastic cartilage covered by a double layer of skin. o It receives the insertion of extrinsic muscles*, which are supplied by the facial nerve. o Sensation is carried by great auricular (from cervical plexus) & auriculotemporal (from mandibular) nerves. *these muscles are insignificant in humans because they don’t move but are prominent in animals, example: bunnies Extra External Ear o The external auditory canal is a curved S-shaped tube about 2.5cm (one inch), that conducts & collects sound waves from the auricle to the tympanic membrane.