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Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer
cancers Review Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer Viktoriia Cherkasova, Olga Kovalchuk * and Igor Kovalchuk * Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 7X8, Canada; [email protected] * Correspondence: [email protected] (O.K.); [email protected] (I.K.) Simple Summary: In recent years, multiple preclinical studies have shown that changes in endo- cannabinoid system signaling may have various effects on intestinal inflammation and colorectal cancer. However, not all tumors can respond to cannabinoid therapy in the same manner. Given that colorectal cancer is a heterogeneous disease with different genomic landscapes, experiments with cannabinoids should involve different molecular subtypes, emerging mutations, and various stages of the disease. We hope that this review can help researchers form a comprehensive understanding of cannabinoid interactions in colorectal cancer and intestinal bowel diseases. We believe that selecting a particular experimental model based on the disease’s genetic landscape is a crucial step in the drug discovery, which eventually may tremendously benefit patient’s treatment outcomes and bring us one step closer to individualized medicine. Abstract: Despite the multiple preventive measures and treatment options, colorectal cancer holds a significant place in the world’s disease and mortality rates. The development of novel therapy is in Citation: Cherkasova, V.; Kovalchuk, critical need, and based on recent experimental data, cannabinoids could become excellent candidates. O.; Kovalchuk, I. Cannabinoids and This review covered known experimental studies regarding the effects of cannabinoids on intestinal Endocannabinoid System Changes in inflammation and colorectal cancer. In our opinion, because colorectal cancer is a heterogeneous Intestinal Inflammation and disease with different genomic landscapes, the choice of cannabinoids for tumor prevention and Colorectal Cancer. -
Attachment 1
Appendix 1 Chemico-Biological Interactions 301 (2019) 2–5 Contents lists available at ScienceDirect Chemico-Biological Interactions journal homepage: www.elsevier.com/locate/chembioint An examination of the linear no-threshold hypothesis of cancer risk T assessment: Introduction to a series of reviews documenting the lack of biological plausibility of LNT R. Goldena,*, J. Busb, E. Calabresec a ToxLogic, Gaithersburg, MD, USA b Exponent, Midland, MI, USA c University of Massachusetts, Amherst, MA, USA The linear no-threshold (LNT) single-hit dose response model for evolution and the prominence of co-author Gilbert Lewis, who would be mutagenicity and carcinogenicity has dominated the field of regulatory nominated for the Nobel Prize some 42 times, this idea generated much risk assessment of carcinogenic agents since 1956 for radiation [8] and heat but little light. This hypothesis was soon found to be unable to 1977 for chemicals [11]. The fundamental biological assumptions upon account for spontaneous mutation rates, underestimating such events which the LNT model relied at its early adoption at best reflected a by a factor of greater than 1000-fold [19]. primitive understanding of key biological processes controlling muta- Despite this rather inauspicious start for the LNT model, Muller tion and development of cancer. However, breakthrough advancements would rescue it from obscurity, giving it vast public health and medical contributed by modern molecular biology over the last several decades implications, even proclaiming it a scientific principle by calling it the have provided experimental tools and evidence challenging the LNT Proportionality Rule [20]. While initially conceived as a driving force model for use in risk assessment of radiation or chemicals. -
Surnames and Migrations: the Barcelona Area (1451-1900)1
Surnames and Migrations: The Barcelona Area (1451-1900)1 Joan Pau Jordà Joana Maria Pujadas-Mora Anna Cabré Spain Abstract Catalan onomastics, and specifically the evolution of surnames, has been conditioned by several demographic, political and social processes that have imparted singular characteristics over the course of centuries. The combination of these factors resulted in a significant number of homonymic surnames, making it impossible to correctly identify their geographical origin based solely on linguistic criteria. As a possible solution to this, this paper proposes the use of the cluster analysis method to introduce a further criterion for their identification and classification. Historical registers of Marriage License Books from the Diocese of Barcelona are the source selected to achieve this goal. These records, which collect information on more than two million surnames, were maintained between 1451 and 1905 in a set of 291 books (Llibres d’Esposalles) kept at the archives of the Barcelona Cathedral. * * * Introduction The study of historical migrations is one of the most difficult demographic phenomena to investigate due to the absence of specific records until recent times. Given this lack, it is necessary to rely on indirect sources and methods that have already shown great potential, such as the analysis of surnames.2 However in the Catalan case – as well as in others – the evolution of onomastics, and specifically the evolution of surnames, has been conditioned by several demographic, political and social factors that have imparted singular characteristics over the course of centuries. The combination of these processes, as explained below, has made it necessary to propose the use of complementary methods to correctly identify the geographical origin of surnames and to complement existing linguistic criteria. -
Role of Endolysosomes and Inter-Organellar Signaling in Brain Disease
University of North Dakota UND Scholarly Commons Biomedical Sciences Faculty Publications Department of Biomedical Sciences 2-2020 Role of endolysosomes and inter-organellar signaling in brain disease Zahra Afghah Xuesong Chen University of North Dakota, [email protected] Jonathan David Geiger University of North Dakota, [email protected] Follow this and additional works at: https://commons.und.edu/bms-fac Part of the Medicine and Health Sciences Commons Recommended Citation Afghah, Zahra; Chen, Xuesong; and Geiger, Jonathan David, "Role of endolysosomes and inter-organellar signaling in brain disease" (2020). Biomedical Sciences Faculty Publications. 1. https://commons.und.edu/bms-fac/1 This Article is brought to you for free and open access by the Department of Biomedical Sciences at UND Scholarly Commons. It has been accepted for inclusion in Biomedical Sciences Faculty Publications by an authorized administrator of UND Scholarly Commons. For more information, please contact [email protected]. Neurobiology of Disease 134 (2020) 104670 Contents lists available at ScienceDirect Neurobiology of Disease journal homepage: www.elsevier.com/locate/ynbdi Review Role of endolysosomes and inter-organellar signaling in brain disease T ⁎ Zahra Afghah, Xuesong Chen, Jonathan D. Geiger Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58201, United States of America ARTICLE INFO ABSTRACT Keywords: Endosomes and lysosomes (endolysosomes) are membrane bounded organelles that play a key role in cell sur- Endolysosomes vival and cell death. These acidic intracellular organelles are the principal sites for intracellular hydrolytic Mitochondria activity required for the maintenance of cellular homeostasis. -
Stem- Spraak- En Taalpathologie
Stem- Spraak- en Taalpathologie Supplement, September 2014 15th International Science of Aphasia Conference Stem-, Spraak- en Taalpathologie 32.8310/supplement/1914 Vol. 19, 2014, Supplement 1, pp. 1-197 ©University of Groningen Press i PREFACE Dear participants, We are very pleased to welcome you to the 15th Science of Aphasia conference, being held from September 19 till September 24, 2015 in the San Camillo Hospital in Venice, Italy The 2014 program theme is: Aphasiology: past, present and future Invited speakers are: Ria De Bleser, Audrey Bowen, Marco Catani, Chris Code, Olga Dragoy, Hugues Duffau, David Howard, Peter Mariën, Gabriele Miceli, Carlo Miniussi, Lyndsey Nickels, Carlo Semenza, Cynthia K. Thompson, Evy Visch-Brink, Frank Zanow. The SoA conferences are intended to bring together senior and junior scientists working in the multidisciplinary field Neurocognition of language and to deal with normal function as well as disorders. The size of the conference has a maximum of about 150 participants to ensure direct interaction between the participants. The focus of this year’s conference is on the past, present and future of Aphasiology: The San Camillo Hospital in Venice-Lido is a health care facility, mainly devoted to the rehabilitation outcomes of traumatic brain injury and spinal cord, stroke, multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, neuropathy and dementia. In 2005 the hospital received recognition from the Ministry of Health of the Institute for Research, Hospitalization and Health Care (IRCCS) specializes in the "discipline of neuro-rehabilitation motor, communication and behavior." The experience in telemedicine, robotics and Brain Computer Interface (BCI) allowed the hospital to develop a communication system based exclusively on the modulation of brain activity recorded with an electroencephalograph, even without moving a muscle. -
BOC-235 12 De Diciembre De 2011.Indd
GOBIERNO de BOLETÍN OFICIAL DE CANTABRIA CANTABRIA LUNES, 12 DE DICIEMBRE DE 2011 - BOC NÚM. 235 AYUNTAMIENTO DE SANTANDER CVE-2011-15994 Citación para notifi cación por comparecencia de providencia de apre- mio 18712/2011 y otros. Con arreglo a lo dispuesto en el artículo 112 de la Ley 58/2003, de 17 de diciembre, General Tributaria, por el presente anuncio se cita a las personas o entes jurídicos que a continuación se relacionan, a quienes no ha sido posible notifi car por causas no imputables a este Servicio (órgano responsable de la tramitación), para que comparezcan en la Recaudación de Tributos Municipales, calle Antonio López, número 6, bajo, en Santander, de 9 a 14 horas, en el plazo de quince días naturales, contados desde el siguiente al de la publicación de este anuncio, para notifi carles por comparecencia actos administrativos que les afectan cuyas referencias constan seguidamente, con la advertencia de que si no atienden este requerimiento la notifi cación se entenderá producida a todos los efectos legales desde el día siguiente al del vencimiento del plazo señalado para comparecer: Procedimiento que motiva las notifi caciones: Apremio administrativo-providencia apremio. CVE-2011-15994 Pág. 36246i boc.cantabria.es 1/10 GOBIERNO de BOLETÍN OFICIAL DE CANTABRIA CANTABRIA LUNES, 12 DE DICIEMBRE DE 2011 - BOC NÚM. 235 APELLIDOS Y NOMBRE O RAZÓN SOCIAL N.I.F. EXPEDIENTE FECHA ENVÍO Nº ENVÍO Abad Villegas Sergio 72078102N 18712/2011 07/11/2011 1536 Abascal Diego Victor Manuel 13721240S 26059/2011 28/10/2011 275 Abascal Diego Victor -
Surname Fore-Names Date of Death Age Plot No ADAMS CHARLOTTE
Surname Fore-Names Date of Death Age Plot No ADAMS CHARLOTTE 7 November 1885 47 L108 ADAMS ELLEN 22 June 1899 66 L108 ADAMS OLIVER 30 October 1912 77 L108 AHERNE ANNIE 09 February 1942 75 D421 AHERNE ELLEN 02 January 1989 97 D421 AHERNE JOHN 08 January 1927 63 D421 AIKEN HENRY 3 December 1872 46 L388 ALEXANDER ALICE ALICIA 20 January 1886 18 M187 ALEXANDER ELIZA 21 June 1886 70 L1378 ALEXANDER IVOR 17 August 1931 75 L1378 ALEXANDER JOHN 24 November 1895 60 M187 ALEXANDER JOHN DAVID 8 September 1876 0 M187 ALEXANDER MARY 02 March 1927 86 M187 ALEXANDER MARY ELIZA 4 January 1876 32 L1378 ALEXANDER PHILIP THOMAS LLEWELLYN 17 March 1886 0 L374/L395 ALEXANDER THOMAS 09 March 1904 47 L374/L395 ALEXANDER WILLIAM 20 October 1886 70 L1378 ALEXANDER WILLIAM THOMAS 15 August 1876 31 L1378 ALLEN ANN 19 October 1901 84 L1342 ALLEN CHARLES 17 August 1882 65 L1342 ALLEN HENRY 16 June 1876 61 L211 ALLEN MARY ANNE 30 January 1885 75 M439 ALLEN SAMUEL WESLEY 06 October 1920 74 M439 ALLEN SARAH 25 February 1900 81 L211 AMESBURY JAMES 14 September 1911 74 L2871 AMESBURY MARY 04 May 1923 56 L2871 ANDERSON ANNIE 08 January 1909 91 X535 ANDERSON WALTER 17 February 1921 90 X535 ANGEL ELLEN MARIA 14 December 1930 83 L971/L995 ANGEL SARAH 11 March 1898 79 L971/L995 ANGEL WILLIAM 26 January 1922 75 L971/L995 ANGEL WILLIAM 16 March 1898 83 L971/L995 ANGEL WILLIAM ALFRED EDWIN 8 October 1876 L971/L995 ANNING JOHN HENRY 21 Sept 1885 62 L920 ANSTEE HARRIETTE 13 February 1912 75 L1065 ANSTEE JOHN 4 May 1886 56 L1065 ARCH ANN 05 March 1907 62 L882 ARCH ESTHER L882 ARCH -
British Family Names
cs 25o/ £22, Cornrll IBniwwitg |fta*g BOUGHT WITH THE INCOME FROM THE SAGE ENDOWMENT FUND THE GIFT OF Hcnrti W~ Sage 1891 A.+.xas.Q7- B^llll^_ DATE DUE ,•-? AUG 1 5 1944 !Hak 1 3 1^46 Dec? '47T Jan 5' 48 ft e Univeral, CS2501 .B23 " v Llb«"y Brit mii!Sm?nS,£& ori8'" and m 3 1924 olin 029 805 771 The original of this book is in the Cornell University Library. There are no known copyright restrictions in the United States on the use of the text. http://www.archive.org/details/cu31924029805771 BRITISH FAMILY NAMES. : BRITISH FAMILY NAMES ftbetr ©riain ano fIDeaning, Lists of Scandinavian, Frisian, Anglo-Saxon, and Norman Names. HENRY BARBER, M.D. (Clerk), "*• AUTHOR OF : ' FURNESS AND CARTMEL NOTES,' THE CISTERCIAN ABBEY OF MAULBRONN,' ( SOME QUEER NAMES,' ' THE SHRINE OF ST. BONIFACE AT FULDA,' 'POPULAR AMUSEMENTS IN GERMANY,' ETC. ' "What's in a name ? —Romeo and yuliet. ' I believe now, there is some secret power and virtue in a name.' Burton's Anatomy ofMelancholy. LONDON ELLIOT STOCK, 62, PATERNOSTER ROW, E.C. 1894. 4136 CONTENTS. Preface - vii Books Consulted - ix Introduction i British Surnames - 3 nicknames 7 clan or tribal names 8 place-names - ii official names 12 trade names 12 christian names 1 foreign names 1 foundling names 1 Lists of Ancient Patronymics : old norse personal names 1 frisian personal and family names 3 names of persons entered in domesday book as HOLDING LANDS temp. KING ED. CONFR. 37 names of tenants in chief in domesday book 5 names of under-tenants of lands at the time of the domesday survey 56 Norman Names 66 Alphabetical List of British Surnames 78 Appendix 233 PREFACE. -
Licensing Department of Land Management
Town of Southampton Licensing Licensing Review Board Phone: (631) 702-1826 Department of Land Management Fax (631) 287-5754 Bulgin & Associates Inc License Number: 000511-0 Licensee - David E Bulgin & Jeffrey Gagliotti Expires: 02/12/2022 Climbers Tree Care Specialist Inc License Number: L002198 Licensee - Alex R Verdugo Expires: 07/10/2021 CW Arborists Ltd License Number: L002378 Licensee - Michael S Gaines Expires: 09/09/2022 Domiano Pools Inc. D/B/A Pool Fection License Number: 002770-0 Licensee - Joseph P Domiano Jr. Expires: 03/11/2022 East End Centro-Vac Inc. P O Box 412 License Number: 000358-0 Licensee - Dennis V. Finnerty Expires: 03/11/2022 Ecoshield Pest Control of NYC License Number: L005737 Licensee - Ermir Hasija Expires: 10/08/2021 EmPower CES, LLC License Number: L002063 Licensee - David G Schieren Expires: 07/08/2022 Field Stone Dirt Works Corp. License Number: L005874 Licensee - Louis Russo Expires: 06/10/2022 Fire Sprinkler Associates Inc License Number: L001682 Licensee - Mark Mausser Expires: 05/13/2022 Four Seasons Solar Products LLC License Number: L000230 Licensee - Joseph Segreti Expires: 07/08/2022 Green Team USA LLC D/B/A Green Team LI License Number: L005839 Licensee - Jay B Best Expires: 03/11/2022 Harald G. Steudte License Number: L990112 Licensee - Expires: 08/14/2021 Heatco, Inc License Number: L001776 Licensee - Dennis Valenti Expires: 08/12/2022 Hopping Tree Care License Number: L004995 Licensee - John N Hopping Expires: 06/12/2021 J Tortorella Heating & Gas Specialists Inc License Number: L002120 Licensee - John Tortorella Expires: 06/10/2022 Joseph W. Labrozzi Sr. LLC License Number: L005636 Licensee - Joseph W. -
The Latest Guild News and Updates
Vol 9 Issue January–March 2008 Also in this issue... • Focus on a one-name study: did the Vayro surname come with the Spanish Armada? • Rounding up non-conformist registers not in the county record office The world’s leading publication for one-namers All the latest Guild news and updates GUILD OFFICERS CHAIRMAN Box G, 14 Charterhouse Buildings Peter Walker Goswell Road, London EC1M 7BA 24 Bacons Drive Tel: 0800 011 2182 Cuffley Guild information E-mail: [email protected] Hertfordshire Website: www.one-name.org EN6 4DU Registered as a charity in England 01707 873778 Sales and Wales No. 802048 [email protected] AS well as Guild publications, the Sales Manager has a supply of Jour- VICE-CHAIRMAN nal folders, ties, lapel badges and Paul Millington back issues of the Journal. The 58 Belmont Street address is: President Worcester Derek A Palgrave MA FRHistS FSG Worcestershire Howard Benbrook WR3 8NN 7 Amber Hill Vice-Presidents 01905 745217 Camberley John Hebden [email protected] Surrey Richard Moore FSG GU15 1EB Iain Swinnerton SECRETARY England Alec Tritton Kirsty Gray E-mail enquiries to: 11 Brendon Close [email protected] Tilehurst, Reading Berkshire RG30 6EA Guild Committee 0118 941 4833 Forum The Committee consists of the four [email protected] THIS online discussion forum is Officers, plus the following: open to any member with access to TREASURER e-mail. You can join the list by Gordon Adshead Cliff Kemball sending a message with your mem- Peter Copsey 168 Green Lane bership number to: Peter Hagger Chislehurst [email protected] Barbara Harvey Kent BR7 6AY To e-mail a message to the forum, David Mellor 0208 467 8865 send it to: Roy Rayment [email protected] [email protected] Roy Stockdill Ken Toll Regional Representatives Sandra Turner * * * * * * * * * * * * Steven Whitaker The Guild has Regional Reps in many areas. -
Participant List
Participant List 10/20/2019 8:45:44 AM Category First Name Last Name Position Organization Nationality CSO Jillian Abballe UN Advocacy Officer and Anglican Communion United States Head of Office Ramil Abbasov Chariman of the Managing Spektr Socio-Economic Azerbaijan Board Researches and Development Public Union Babak Abbaszadeh President and Chief Toronto Centre for Global Canada Executive Officer Leadership in Financial Supervision Amr Abdallah Director, Gulf Programs Educaiton for Employment - United States EFE HAGAR ABDELRAHM African affairs & SDGs Unit Maat for Peace, Development Egypt AN Manager and Human Rights Abukar Abdi CEO Juba Foundation Kenya Nabil Abdo MENA Senior Policy Oxfam International Lebanon Advisor Mala Abdulaziz Executive director Swift Relief Foundation Nigeria Maryati Abdullah Director/National Publish What You Pay Indonesia Coordinator Indonesia Yussuf Abdullahi Regional Team Lead Pact Kenya Abdulahi Abdulraheem Executive Director Initiative for Sound Education Nigeria Relationship & Health Muttaqa Abdulra'uf Research Fellow International Trade Union Nigeria Confederation (ITUC) Kehinde Abdulsalam Interfaith Minister Strength in Diversity Nigeria Development Centre, Nigeria Kassim Abdulsalam Zonal Coordinator/Field Strength in Diversity Nigeria Executive Development Centre, Nigeria and Farmers Advocacy and Support Initiative in Nig Shahlo Abdunabizoda Director Jahon Tajikistan Shontaye Abegaz Executive Director International Insitute for Human United States Security Subhashini Abeysinghe Research Director Verite -
Muslims in Spain, 1492–1814 Mediterranean Reconfigurations Intercultural Trade, Commercial Litigation, and Legal Pluralism
Muslims in Spain, 1492– 1814 Mediterranean Reconfigurations Intercultural Trade, Commercial Litigation, and Legal Pluralism Series Editors Wolfgang Kaiser (Université Paris I, Panthéon- Sorbonne) Guillaume Calafat (Université Paris I, Panthéon- Sorbonne) volume 3 The titles published in this series are listed at brill.com/ cmed Muslims in Spain, 1492– 1814 Living and Negotiating in the Land of the Infidel By Eloy Martín Corrales Translated by Consuelo López- Morillas LEIDEN | BOSTON This is an open access title distributed under the terms of the CC BY-NC 4.0 license, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. Further information and the complete license text can be found at https://creativecommons.org/licenses/by-nc/4.0/ The terms of the CC license apply only to the original material. The use of material from other sources (indicated by a reference) such as diagrams, illustrations, photos and text samples may require further permission from the respective copyright holder. Cover illustration: “El embajador de Marruecos” (Catalog Number: G002789) Museo del Prado. Library of Congress Cataloging-in-Publication Data Names: Martín Corrales, E. (Eloy), author. | Lopez-Morillas, Consuelo, translator. Title: Muslims in Spain, 1492-1814 : living and negotiating in the land of the infidel / by Eloy Martín-Corrales ; translated by Consuelo López-Morillas. Description: Leiden ; Boston : Brill, [2021] | Series: Mediterranean reconfigurations ; volume 3 | Original title unknown. | Includes bibliographical references and index. Identifiers: LCCN 2020046144 (print) | LCCN 2020046145 (ebook) | ISBN 9789004381476 (hardback) | ISBN 9789004443761 (ebook) Subjects: LCSH: Muslims—Spain—History. | Spain—Ethnic relations—History.