Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000020585Cyc: Alteromonas mediterranea DE Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari

pro pro L-fucose

GlnK RS01880 FucP RS01650 RS01915 PutP PutP

L-fucose pro pro

RS01595

Aminoacyl-tRNA Charging Amino Acid Degradation N 6 -(3-methylbut- a nascent peptidoglycan a peptidoglycan UDP-N-acetyl-α-D- a nascent DNA with adenine:7,8- (4R)-4-hydroxy- a peptidoglycan a [protein]-L- queuosine at an [amino-group a sulfurated + a nucleoside an L-asparaginyl- tRNA charging L-valine degradation I 2-en-1-yl)- γ γ muramoyl-L-alanyl- NADPH NAD a [glutamine- dihydro-8- dimer (meso- glutamate-O 5 Fermentation mixed acid fermentation L-isoleucine degradation I Alcohol Degradation with (L-alanyl- -D- with (L-alanyl- -D- peptidoglycan ATP 2-oxoglutarate RNA glu position 34 Asn carrier protein]- L-leucine degradation I L-threonine degradation I L-arginine degradation [sulfur carrier] 37 synthetase]- triphosphate [tRNA ] adenosine glutamyl-meso-2,6- glutamyl-meso-2,6- γ-D-glutamyl-meso- (meso-DAP oxoguanine mismatch diaminopimelate -methyl-ester of a tRNA Asp C-terminal-γ- II (AST pathway) D-alanyl-D-alanine L-tyrosine in tRNA diaminopimeloyl- diaminopimeloyl-D- 2,6-diaminopimelate containing) containing) (L-glutamate 5- Phe Gly Trp Arg asp Asn Thr Gln Met Met Cys Ile Pro His Tyr Val phosphoenolpyruvate val phe a tRNA gly a tRNA trp a tRNA arg a tRNA tRNA asp asn tRNA thr a tRNA gln a tRNA elongator tRNA met initiator tRNA met cys a tRNA ile a tRNA pro a tRNA his a tRNA tyr a tRNA val a tRNA ile glycerol and glycerophosphodiester degradation alanine) tetrapeptide NAD(P)(+) bifunctional N-acetyl- leu thr D-alanyl-D-alanine) A/G-specific DNA- chemotaxis tRNA aminoacyl- semialdehyde-2- a tRNA Ala ala lys a tRNA Lys leu a tRNA Leu ser a tRNA ser arg tRNA (N6-isopentenyl transhydrogenase 4-hydroxy-2- gamma- glu pentapeptide bifunctional [glutamate- adenine directed RNA yl)-L-glutamate glu a tRNA branched-chain branched-chain serine/threonine UDP-N- membrane-bound oxoglutarate penicillin- response glutamyl- tRNA phosphoenolpyruvate branched-chain arginine N- glycerol adenosine(37)-C2)- (Re/Si-specific): -ammonia ligase]- polymerase glutamyl- glycine-- arginine- threonine- glutamine- methionine- methionine- isoleucine- proline-- histidine- valine-- pyruvate kinase: pyk amino acid amino acid dehydratase: acetylmuramoyl- lytic murein glycosylase: binding regulator protein- Q(34) hydrolase: phenylalanine- tryptophan- aspartate- asparagine- cysteine-- tyrosine-- carboxylase: ppc amino acid succinyltransferase: a glycerophosphodiester methylthiotransferase MADE_RS18895 aldolase/2- phosphate aminotransferase: aminotransferase: MADE_RS16755 penicillin- tripeptide--D- transglycosylase adenylyl-L-tyrosine mutY protein subunit glutamate synthetase pth -tRNA ligase: tRNA ligase: -tRNA alanine--tRNA -tRNA lysine--tRNA -tRNA -tRNA -tRNA leucine--tRNA -tRNA serine--tRNA -tRNA -tRNA tRNA ligase: -tRNA tRNA ligase: -tRNA tRNA ligase: tRNA ligase: (2Z)-2-aminobut- astA MiaB: miaB MADE_RS18900 dehydro-3-deoxy- an [amino-groupreductase: aminotransferase: N 2 -succinyl- alanyl-D- alanine phosphorylase/ 2: mrdA omega: rpoZ pheS pheT glyS glyQ ligase: trpS ligase: alaS ligase: argS ligase: lysS ligase: aspS ligase: asnS ligase: thrS ligase: leuS ligase: glnS ligase: serS ligase: metG ligase: metG MADE_RS11920 ligase: ileS MADE_RS13080 ligase: hisS MADE_RS15540 MADE_RS15745 MADE_RS02090 4-methyl-2-MADE_RS02090 2-enoate binding MltF: mltF phosphogluconate methylesterase: GluQRS: aminoacyl- carrier protein]- pyruvate MADE_RS02090 succinate MADE_RS18905 [glutamate-- argC oxaloacetate oxopentanoate L-arginine glycerophosphodiester protein ligase: murF [+ 3 isozymes] an apurinic site aldolase: eda [+ 3 isozymes] MADE_RS05550 gluQRS tRNA C-terminal-γ- 3-methyl-2-oxobutanoate (3S)-3-methyl-2- glycerol phosphodiesterase: dehydrogenase, 2: mrdA Si-specific NAD(P)(+) ammonia-ligase] an L-phenylalanyl- an L-tryptophanyl- an L-asparaginyl- an L-glutaminyl- an L-methionyl- an L-methionyl- N-succinylarginine adenine within DNA a peptidoglycan chemotaxis hydrolase: (5-phospho- a glycyl-[tRNA Gly ] an L-alanyl-[tRNA Ala ] an L-arginyl-[tRNA Arg ] an L-lysyl-[tRNA Lys ] an L-aspartyl-[tRNA asp ] an L-threonyl-[tRNA Thr ] an L-leucyl-[tRNA Leu ] an L-seryl-[tRNA ser ] an L-cysteinyl-[tRNA Cys ] an L-isoleucyl-[tRNA Ile ] an L-prolyl-[tRNA Pro ] an L-histidyl-[tRNA His ] an L-tyrosyl-[tRNA Tyr ] an L-valyl-[tRNA Val ] an L-glutamyl-[tRNA Glu ] D-lactate malate oxopentanoate MADE_RS02600 hydrophobic transhydrogenase: adenylyltransferase: Phe Trp Asn [tRNA Gln ] Met Met dihydrolase: astB UDP-N-acetyl-α-D- a mature a nascent with D,D cross- D-ala response glutamyl- arfB L-glutamyl)- [tRNA ] [tRNA ] [tRNA ] [elongator tRNA ] [initiator tRNA ] dehydrogenase: dld dehydrogenase: mdh membrane anchor sthA glnE RNA nitrite nitrite 2 glycerol kinase glycerophosphodiester muramoyl-L-alanyl- pyruvate links (meso- queuosine at L-glutamate RS07525 2-iminobutanoate N -succinyl- protein: sdhD a nascent peptidoglycan peptidoglycan peptidoglycan glyoxylate regulator protein- formate formate D-lactate malate 3-methylbutanoyl- phosphodiesterase: glpQ γ diaminopimelate L-ornithine GlpK: glpK with D,D cross-links D-ala -D-glutamyl-meso- with (L-alanyl- (meso-DAP glutamate position 34 dehydrogenase: Asp dehydrogenase: dld formate acetyl-CoA CoA 6 a [glutamine containing) Asn isobutanoyl-CoA (2S)-2- succinylornithine N -(3-methylbut- (meso-diaminopimelate 2,6-diaminopimeloyl- γ-D-glutamyl- containing) with NADH NADP + methylesterase: of a tRNA asn tRNA MADE_RS17745 an unsulfurated synthetase]-O isovaleryl-CoA methylbutanoyl-CoA transaminase: 5'-deoxyadenosine 2-en-1-yl)-2- met containing) D-alanyl-D-alanine meso-2,6- GlcNAc terminus MADE_RS01975 nitrite nitrite dehydrogenase: sn-glycerol 3-phosphate [sulfur carrier] 4 -(5'-adenylyl) RS12470 (R)-lactate phosphate citrate synthase: (S)-malate MADE_RS02370 (methylsulfanyl) diaminopimeloyl- formate formate 2-oxobutanoate 37 -L-tyrosine MADE_RS08235 N 2 -succinyl- adenosine D-alanine) acetyltransferase: pta MADE_RS09575 glycerol-3-phosphate a [protein]-α- Amino Acid Biosynthesis fumarate hydratase: isovaleryl-CoA L-glutamate 5- in tRNA tetrapeptide MeOH superpathway of L- L-histidine biosynthesis superpathway of L-methionine 2-methylcitrate dehydrogenase: glpD L-glutamate L-lysine biosynthesis I L-cysteine biosynthesis I superpathway superpathway of L-serine CO H acetaldehyde MADE_RS09970 methylacrylyl-CoA dehydrogenase: (E)-2- semialdehyde isoleucine biosynthesis I 2 2 synthase: prpC biosynthesis (by sulfhydrylation) of L-threonine and glycine biosynthesis I acetyl phosphate class II fumarate MADE_RS13905 methylcrotonoyl-CoA ethanol fatty acid succinylglutamate- DHAP oxaloacetate PRPP biosynthesis hydratase: fatty acid an inactive α-Kdo-(2->4)- a reduced L-alanyl-γ-D- a [bis(guanylyl 2445 UDP-N-acetyl- a peptidoglycan α ε an insertion ser Metabolic Regulator Biosynthesis oxidation 3-methylcrotonyl- propanoyl-CoA semialdehyde a guanine N ,N -diacetyl-lysyl- an L-cysteinyl- asp oxaloacetate 3-phospho-D-glycerate acetate kinase: dehydrogenase: citrate MADE_RS15625 a reduced α ubiquinone-6 a protein with glutathione α 3',5'-ADP aspartate/ CoA oxidation dehydrogenase: ribonucleoside SAM -Kdo-(2->6)- a palmitoleoyl-[acp] electron-transfer glutamyl-meso-2,6- molybdopterin) cys in 23S rRNA -D-muramoyl- D-glt dimer (E. faeciums) D-alanyl-D-alanine sequence Cys a metal a metal ATP lysine-sensitive oxaloacetate MADE_RS15225 complex subunit Degradation/ flavodoxin a disulfide bond ATP [tRNA ] tyrosine/aromatic phosphoglycerate MADE_RS07260 complex triphosphate lipid IV (E. coli) flavoprotein diaminopimeloyl- UDP-N-acetyl- cofactor bifunctional L-alanine element IS30 biotin cation cation aspartate/ serine O- aspartate/ acetyl/propionyl/ phosphate astD A DDE-type 3'(2'),5'- phosphoribosyltransferase: aspartokinase dehydrogenase: serA ppGpp metabolism aconitate hydratase fumarate alpha FadJ: fadJ Utilization/ α RS17025 aminotransferase: glycine betaine subunit alpha 2 reductase D-alanine -D-muramate chaperone]- 23S rRNA tyrosine/aromatic acetyltransferase: tyrosine/aromatic ethanol AcnA: acnA methylcrotonyl- propionyltransferase: pta N - penicillin- penicillin- integrase/ bisphosphate hisG 3: lysC 3-phosphooxypyruvate acetate (S)-3-hydroxy- Assimilation - Other electron transfer L-cysteine acetate acetate MADE_RS11050 aminotransferase: cysE aminotransferase: biosynthesis I (Gram- CoA carboxylase FadJ: fadJ succinylglutamate LpxL/LpxP glutathione- (guanine(2069)-N(7) UDP-N- binding transposase/ aminoacyl- nucleotidase bifunctional pppGpp [+ 2 isozymes] isobutanoyl-CoA propanoyl acrylonitrile flavoprotein- binding asp β MADE_RS11050 MADE_RS11050 negative bacteria) (2S,3S)-3-hydroxy-2- anaerobic family Kdo(2)- UDP-N- dependent )-methyltransferase acetylmuramoyl- protein recombinase: bifunctional biotin- tRNA CysQ: cysQ 1-(5-phospho- -D-ribosyl)-ATP serine O- 3-phosphoserine/ bifunctional GTP subunit alpha: phosphate succinylglutamate degradation I protein aspartate kinase/ cis-aconitate methylbutanoyl-CoA ubiquinone RlmK/23S rRNA -[acetyl-CoA- acetyltransferase: asp phosphohydroxythreonine diphosphokinase/ guanosine-5'-triphosphate,3'- choline MADE_RS08220 ribonucleoside- lipid IV(A) lauroyl/ acetylmuramate:L- disulfide-bond IscS subfamily L-alanine-- 2: mrdA 2: mrdA MADE_RS17275 hydrolase: 3'(2'),5'- homoserine desuccinylase: astE oxidoreductase: (guanine(2445)-N(2) carboxylase] lysine-sensitive bifunctional asp cysE guanosine-3',5'-bis choline succinate acetate kinase: triphosphate palmitoleoyl alanyl-gamma-D- oxidoreductase: D-glutamate pth bisphosphate dehydrogenase transaminase: serC diphosphate phosphatase: methylcrotonoyl- acrylonitrile MADE_RS11125 cysteine transposase: aspartokinase phosphoribosyl- aconitate hydratase acyltransferase: yghU )-methyltransferase synthetase/biotin lysine-sensitive pyrophosphate 3'- bifunctional GTP MADE_RS02705 dehydrogenase: CoA carboxylase: MADE_RS07260 glu reductase glutamyl- meso- desulfurase: ligase: murD a peptidoglycan an insertionMADE_RS20385 aminoacyl- nucleotidase 3: lysC AMP cyclohydrolase/ I: thrA lysine-sensitive AcnA: acnA (S)-3-hydroxy-isobutanoate RlmL: rlmKL Nα,Nε-diacetyl- operon repressor: O-acetyl-L-serine aspartokinase O-phospho-L-serine pyrophosphohydrolase: spoT diphosphokinase/ MADE_RS12240 activating lpxL diaminopimelate glutaredoxin MADE_RS13230 an N 2 - tetramer with a D-ala tRNA CysQ: cysQ hydrogen sulfide [+ 2 isozymes] MADE_RS08230 an oxidized lysyl-D-alanine D-ala sequence IS30 MADE_RS17140 bifunctional phosphoribosyl-ATP L-aspartyl-4-phosphate aspartokinase 3: lysC guanosine-3',5'-bis 2-methylacetoacetyl-CoA propanoate protein: nrdG + ligase: mpl 2445 GTP diphosphokinase: relA choline 3-hydroxyisobutyrate H ubiquinol-6 3: grxC [+ 2 isozymes] methylguanine UDP-N-acetyl- D,D cross-link with integrated hydrolase: + + diphosphatase HisIE: 3: lysC 3-methylglutaconyl- acrylamide electron-transfer AMP H RS17660 H aspartate kinase/ bifunctional phosphoserine pyrophosphate 3'- dehydrogenase: D-threo-isocitrate dehydrogenase: Kdo - in 23S rRNA α-D-muramoyl-L- (Enterococcus arfB TCA cycle CoA 2 flavoprotein transposon homoserine MADE_RS12465 aspartate- bifunctional cysteine aspartate kinase/ pyrophosphohydrolase: spoT TCA cycle I (prokaryotic) mmsB an active acyl-carrier protein (palmitoleoyl) alanyl-D-glutamate biotinyl-5'- phosphatase SerB: serB betA acetyl-CoA C- amidase: UDP-N-acetylmuramoyl- a protein with a [bis(guanylyl faecium) dehydrogenase semialdehyde aspartate kinase/ synthase A: cysK homoserine betaine aldehyde NADP-dependent 5'-deoxyadenosine a flavodoxin ribonucleoside -lipid IV γ GSSG adenylate 1-(5-phospho-β-D-ribosyl)-AMP (S)-methylmalonate- L-tryptophan degradation to MADE_RS07840 met A L-alanyl- -D- reduced L- ala molybdopterin) dehydrogenase: acyltransferase semiquinone I: thrA homoserine dehydrogenase acetyl-CoA isocitrate triphosphate Cys F0F1 ATP ser semialdehyde 2-amino-3-carboxymuconate amidase: glutamyl-meso-2,6- cysteine residues cofactor cys a tRNA + + asd betaine-aldehyde FadA: fadA H H phosphoribosyl-AMP dehydrogenase I: thrA dehydrogenase: reductase diaminopimeloyl- chaperone]-S- synthase L-aspartyl- cys GTP ppGpp dehydrogenase: HMG-CoA [+ 2 isozymes] semialdehyde MADE_RS19100 cyclohydrolase: hisI aspartate- I: thrA serine oxaloacetate MADE_RS09045 methylmalonate- D-alanine sulfanyl-L-cysteine 4-phosphate L-aspartyl- betB citrate synthase: bifunctional semialdehyde hydroxymethyltransferase: semialdehyde hydroxymethylglutaryl- trp acrylate L-aspartyl- 4-phosphate MADE_RS09575 2-oxoglutarate aspartate- phosphoribosyl- dehydrogenase: MADE_RS12745 bifunctional GTP dehydrogenase: CoA lyase: acetyl-CoA propanoyl-CoA tryptophan 2,3- NAD(P) glycine betaine 2069 L-alanyl-γ-D- + + 4-phosphate 2-methylcitrate (S)-3-amino-2- a mature peptidoglycan a methylated a DNA containing a mature a [glutamine a guanine a [protein]-α- a (2E,4Z)-2,4- a [protein] an L-cysteinyl- H transhydrogenase H semialdehyde AMP cyclohydrolase/ MADE_RS12045 aspartate- diphosphokinase/ MADE_RS16050 MADE_RS08215 dioxygenase: a peptidoglycan 2-oxoglutarate MoO - synthase: prpC (meso-diaminopimelate nucleobase an apurinic/ peptidoglycan synthetase]-O 2 glutamyl-L-lysyl- C-terminal glu Pro sulfate gly methylpropanoate (n) in 23S rRNA ATP L-glutamate ATP dienoyl-CoA [tRNA ] dehydrogenase: phosphoribosyl-ATP aspartate- semialdehyde guanosine-3',5'-bis malate dehydrogenase: mdh MADE_RS05760 4 molybdopterin L-aspartate 4- superpathway of branched chain amino acid biosynthesis acetoacetate N-Formyl-L- L-proline degradation I containing) within DNA apyrimidinic site (meso-DAP -(5'-adenylyl) bifunctional protein-glutamate O- D-alanyl-D-alanine NADPH- L-glutamate asd diphosphatase HisIE: semialdehyde semialdehyde dehydrogenase: pyrophosphate 3'- bifunctional GTP malate dehydrogenase: kynurenine cofactor sulfate hydrogencarbonate 1,6-anhydro-N- containing) -L-tyrosine 23S rRNA methyltransferase adenylate/guanylate dependent 2,4- a metal a metal aspartate- MADE_RS12465 dehydrogenase: asd ammonia assimilation cycle III pyrophosphohydrolase: spoT diphosphokinase/ MADE_RS17745 CheR: RS02880 adenylyltransferase: pyruvate L-tyrosine degradation I acetylmuramyl- alpha- endonuclease III: (guanine(2069)-N(7) cyclase domain- penicillin- dienoyl-CoA Cys- cation cation 1-(5-phospho-β-D-ribosyl)- asd thr GTP diphosphokinase: relA guanosine-3',5'-bis (S)-malate citrate tRNA-uridine 2-thiolation Macromolecule Modification pro membrane-bound 30S semialdehyde cysN cysD aspartate- nucleoside- ketoglutarate- )-methyltransferase molybdenum cofactor MADE_RS05255 containing protein: binding reductase: tRNA(Pro) and selenation (bacteria) bifunctional lytic murein L-alanine MADE_RS06165 membrane-bound bifunctional [glutamate- ribosomal dehydrogenase: 5-[(5-phosphoribosylamino) aspartate- acetolactate semialdehyde diphosphate kinase: ndk pyrophosphate 3'- Polymeric Compound dependent RlmK/23S rRNA guanylyltransferase: MADE_RS09020 MADE_RS12225 (2S,4S)-4- ammonium transglycosylase amidase lytic murein -ammonia ligase]- protein-glutamate O- protein protein deacylase: MADE_RS12045 methylideneamino]imidazole- semialdehyde APS serine/threonine pyrophosphohydrolase: spoT aconitate hydratase tyr proline Degradation dioxygenase AlkB: bifunctional DNA- synthase dehydrogenase: fumarate hydratase: L-kynurenine MltF: mltF AmpD: ampD transglycosylase (guanine(2445)-N(2) MADE_RS08425 methyltransferase class I adenylate 2: mrdA NADPH- S6--L- ybaK a metal a metal 4-carboxamide hydroxy-2,3,4,5- dehydratase: NADP-specific glu GDP AcnA: acnA cys aspartate/ dehydrogenase/L- formamidopyrimidine adenylyl-L-tyrosine RS06475 L-aspartate 4- dehydrogenase: large subunit: MADE_RS12045 L-histidine degradation I L-citrulline degradation MADE_RS03510 )-methyltransferase CheR: dependent 2,4- cation cation tetrahydrodipicolinate adenylyl- MADE_RS16755 MADE_RS09970 glutamate gamma- glycogen degradation II [+ 3 isozymes] glycosylase/ MltF: mltF phosphorylase/ cyclase: glutamate 1-(5-phosphoribosyl)-5- MADE_RS12045 MADE_RS18205 glutamate [+ 2 isozymes] tyrosine/aromatic RlmL: rlmKL adenylyl semialdehyde sulfate L-aspartate 4- class II fumarate [glutamate-- 7 MADE_RS14840 MADE_RS13940 L-alanyl-γ-D- dienoyl-CoA ligase: rimK [(5- phosphoribosylamino) 4-hydroxy- (2Z)-2-aminobut- 2-oxoglutaratedehydrogenase: glutamate- cysteine aminotransferase: semialdehyde ditrans,octacis- a peptidoglycan DNA-(apurinic [+ 3 isozymes] an N - a [protein]-L- a nucleobase molybdenum cyclic-AMP Pro bifunctional tetrahydrodipicolinate L-aspartate 4- kinase: acetolactate semialdehyde -ammonia hydratase: MADE_RS15625 3-(4- a mature peptidoglycan undecaprenyldiphospho- or apyrimidinic ammonia-ligase] methylguanine 2069 glutamate-O 5 glutamyl-L- D-ala reductase: cys a tRNA methylideneamino]imidazole-4- 2-enoate gdhA fumarate cis-aconitate desulfurase: his L-citrulline MADE_RS11050 dehydrogenase a glycogen a mature peptidoglycan pentapeptide formaldehyde succinate cofactor a metal a metal reductase: dapB semialdehyde cysC synthase: γ N-acetyl-(N- within DNA site) lyase: mutM adenylyltransferase: in 23S rRNA -methyl-ester lysyl-D-alanine MADE_RS15110 RS01785 aspartate kinase/ carboxamide isomerase: hisA bifunctional glutamate ligase: glnA aconitate hydratase MADE_RS13210 hydroxyphenyl) PutA: putA with (L-alanyl- -D- strand (non- a mature GlcNAc-1,6- a [protein] C- cation cation MADE_RS02655 histidine ornithine 3-hydroxy- (S)-1-pyrroline- glycogen/starch/ glnE a (2E)-2- homoserine (S)-2,3,4,5- bifunctional aspartate kinase/ AcnA: acnA [+ 2 isozymes] pyruvate glutamyl-meso-2,6- reducing terminus) acetylglucosaminyl)muramate peptidoglycan anhMurNAc- terminal α-L- phosphoribulosylformimino- PAPS synthase large succinate dehydrogenase ammonia- carbamoyltransferase: L-kynurenine 5-carboxylate (n) enoyl-CoA dehydrogenase ilvN [+ 2 isozymes] an [L-cysteine alpha-glucan diaminopimeloyl-D- (meso-DAP γ glutamate-α- AICAR-phosphate tetrahydrodipicolinate aspartate kinase/ homoserine subunit: gltB lyase: hutH MADE_RS02515 4-hydroxyphenylpyruvate a 3'-terminal a 5'-phospho- L-Ala- -D-Glu- phosphoadenylyl- imidazole flavoprotein subunit: sdhA carbamoyl phosphorylase: I: thrA 2,3,4,5- homoserine 2-iminobutanoate (S)-2-acetolactate dehydrogenase desulfurase]-S- urocanate dioxygenase: hppD kynureninase: alanine) tetrapeptide containing) DAP-D-Ala a [glutamine- L-glutamate a metal a metal glycerol Cell Structure Biosynthesis phosphate MADE_RS07555 unsaturated sugar [DNA] ADP RS04970 tetrahydropyridine- dehydrogenase sulfate reductase: I: thrA sulfanyl-L-cysteine kynU synthetase]- cation imidazole glycerol phosphate urocanate cation L-homoserine I: thrA MADE_RS16410 ketol-acid ammonium gln glutamine- homogentisate L-tyrosine phosphate 2,6-dicarboxylate N- L-glutamate-5- an α-limit dextrin reductoisomerase: L-homoserine synthase: lipid IV biosynthesis (P. putida) succinate D-threo-isocitrate hydratase: 3-hydroxyanthranilate succinyltransferase: A lipid IV biosynthesis (E. coli) Kdo transfer to lipid hydrolyzing synthase: hisH hisF sulfite hisH hisF A NADP-dependent MADE_RS04435 homogentisate semialdehyde homoserine dapD L-homoserine ilvC carbamoyl- 4-alpha- a metal a metal IV II (Haemophilus) isocitrate dehydrogenase: a [TusA sulfur- 2503 sn-glycero-3- 3 an N-terminal- (2R)-2,3- [+ 7 isozymes] a (3R)-3- A 4-imidazolone- 1,2-dioxygenase: bifunctional glucanotransferase: adenine a heme(III)-bound an N -methyladenine an N-modified phosphoenol (S)-1-pyrroline- a (2E,4E)-2,4- RS03195 kinase: thrB assimilatory 2-oxobutanoate homoserine a (3R)-3- ADP-forming succinate- carrier protein]-S- phosphate MoO - L-methionyl-L- H O Ala cation cation N-succinyl-2-amino- hydroxydecanoyl- UDP-N-acetyl- MADE_RS09045 MADE_RS07625 in 23S rRNA a CcmAB complex 2 phospho-N- in DNA 2 pyruvate 5-carboxylate ala UDP-N-acetyl- dienoyl-CoA a glycyl-[tRNA ] AICAR D-erythro-1-(imidazol-4- homoserine O- dihydroxy-3- kinase: thrB hydroxytetradecanoyl- UDP-N-acetyl- CMP-Kdo lipid IV (E. coli) -CoA ligase: sucC sucD 5-propanoate synthase: proline malQ CcmCDE complex molybdopterin GTP aminoacyl-[tRNA] GTP dGDP ATP roseoflavin 6-ketopimelate sulfite reductase α A sulfanyl-L-cysteine molybdopterin (arachidonoyl) cysteinyl-[protein] bifunctional α-D-muramate NADPH- O-phospho- yl)-glycerol 3-phosphate acetyltransferase: acetolactate methylbutanoate [acp] -D-glucosamine α 4-maleyl- 2-amino-3- dehydrogenase/L- a debranched 5'-phosphate (NADPH): cysI [acp] -D-glucosamine imidazolonepropionase: carA carB cofactor ethanolamine proline dependent 2,4- L-homoserine MADE_RS07150 synthase dihydroxy-acid O-phospho- acetoacetate carboxymuconate- glutamate gamma- α-limit dextrin bifunctional tRNA DNA-3- a metal a metal bifunctional histidinol- MADE_RS16420 glu acyl-ACP--UDP-N- 3-deoxy-D-manno- MADE_RS04425 type I methionyl dehydrogenase/L- dienoyl-CoA RS10190 threonine large subunit: dehydratase: L-homoserine acyl-ACP--UDP-N- carbamate 6-semialdehyde semialdehyde (adenosine(37)-C2) cytochrome c methyladenine aminoacyl- GTPase UDP-N- D-tyrosyl- cation cation phosphatase/ O-acetyl-L- acetylglucosamine O- octulosonic acid succinyl-CoA 2-oxoglutarate maleylacetoacetate molybdenum cofactor glutamate gamma- reductase: bifunctional MADE_RS18205 ilvD acetylglucosamine O- a [TusD sulfur- N-formimino- dehydrogenase glycogen/starch/ biogenesis heme- glycerophosphodiester tRNA aminopeptidase: pyruvate acetylmuramate- tRNA(Tyr) synthase: imidazoleglycerol- N-succinyl-L,L-2,6- homoserine hydrogen sulfide threonine isomerase: maiA -methyltransferase guanylyltransferase: glycosylase I: Era: era semialdehyde acyltransferase: lpxA transferase: carrier protein]-S- transporting phosphodiesterase: glpQ hydrolase: map kinase: pyk -L-alanine MADE_RS12225 riboflavin deacylase: thrC phosphate diaminopimelate acetolactate 3-methyl-2- synthase: acyltransferase: lpxA L-glutamate PutA: putA alpha-glucan TrmG/ribosomal MADE_RS17595 [+ 3 isozymes] MADE_RS02200 sulfanyl-L-cysteine 4-fumaryl- MADE_RS08425 dehydrogenase kinase/FAD phosphorylase: ATPase glycerophosphodiester pth ligase: murC NADPH- dtd a metal dehydratase succinyl- synthase: oxobutanoate thrC UDP-3-O-[(3R)-3- cellulose D-glucopyranose RNA large subunit DNA-3- PutA: putA synthetase: RS18410 a metal serine serine thr UDP-3-O-[(3R)-3- formimidoylglutamase: acetoacetate glu MADE_RS07555 CcmA: ccmA phosphodiesterase: dependent 2,4- RS00680 HisB: hisB MADE_RS02655 hydroxydecanoyl]- α-Kdo-(2->6)- biosynthesis methyltransferase aminoacyl- an N-terminal L- + cation cation thr thr diaminopimelate hydroxymyristoyl]-N- 2-oxoglutarate hutG CO bis(guanylyl methyladenine phosphate H dienoyl-CoA ribF thr 2 L-methionine degradation MADE_RS02600 met glu UDP-N-acetyl- desuccinylase: ilvN 2-isopropylmalate branched-chain L-tryptophan biosynthesis N-acetyl-α-D- lipid IV (E. coli) glycine cleavage RlmN: trmG/rlmN glycosylase I: tRNA cysteinyl-[protein] GDP pyruvate 3-(imidazol-4-yl)-2- α A dehydrogenase α molybdopterin) dGTP Ala serine/threonine acetyl- -D-glucosamine cellulose a [TusE sulfur I (to L-homocysteine) -D- hydrolase: α-D-muramoyl- reductase: a tRNA gly dapE (S)-2-aceto-2- synthase: leuA amino acid glucosamine UDP-3-O-acyl-N- 3-deoxy-D-manno- E1 component: a heme(III)-bound cofactor MADE_RS00040 dehydratase: oxopropyl phosphate L-homocysteine carrier protein]-S glu glucopyranose MADE_RS15110 roseoflavin hydroxybutanoate aminotransferase: UDP-3-O-acyl-N- UDP- a uridine 34 in tRNA a [glycine-cleavage a CcmABCD complex arfB L-alanine a metal a metal serine serine succinyl- acetylglucosamine octulosonic MADE_RS09600 1-phosphate glucokinase: a 2-methyladenine 2503 CcmE protein sn-glycerol a (2E)-2- adenine RS10215 MADE_RS16755 gln -sulfanylcysteine fumarate complex H protein] N 6 anandamide cation cation SstT histidinol-phosphate (2S)-2- MADE_RS02090 chorismate acetylglucosamine acid kinase: forming met glycine cleavage system glk 5'-deoxyadenosine met enoyl-CoA thr thr diaminopimelate methionine methionine ketol-acid deacetylase: lpxC in 23S rRNA 3-phosphate an apurinic site dinucleotide (2Z)-2-aminobut- transaminase: hisC isopropylmalate deacetylase: lpxC UDP-3-O-(3- cellulose L-tryptophan methionine -[(R)-lipoyl]-L-lysine aminomethyltransferase 3-methyladenine desuccinylase: synthase: synthase: reductoisomerase: MADE_RS00295 tRNA 2- alpha-D-glucose an N-modified an uncharged 2-enoate 3-isopropylmalate UDP-3-O-(3- synthase degradation I adenosyltransferase: GcvT: gcvT within DNA dapE MADE_RS11395 MADE_RS11395 ilvC anthranilate hydroxymyristoyl) 4-O-phospho-α- thiouridine(34) glycine cleavage system phosphate-specific tRNA dehydratase: val hydroxydecanoyl) catalytic MADE_RS04275 amino acid a metal a metal L-histidinol phosphate synthase component -α-D-glucosamine Kdo-(2->6)-lipid IV NADPH repair (prokaryotes) (via anthranilate) aminomethyltransferase aminomethyl- RS10320 (R)-2,3-dihydroxy- α A synthase phosphoglucomutase: cation methionine methionine leuD leuC - -D-glucosamine UDP-3-O-(3- subunit: SAM cation L,L-diaminopimelate 3-methylpentanoate 1: MADE_RS07040 UDP-3-O-(3- MnmA: mnmA GcvT: gcvT transferring MADE_RS07550 histidinol- synthase: synthase: hydroxymyristoyl) bcsA trp dihydroxy-acid hydroxymyristoyl) NADPH dihydrolipoyl glycine [+ 2 isozymes] a ring-opened 7- a thiocarboxylated cyclic a [protein]- a [ThiI sulfur- a peptide with a PepB N-acetyl-α- 2-iminobutanoate phosphatase: metH metH 2-isopropylmaleate glucosamine N- cellulose tryptophan 2,3- an N-terminal an L-phenylalanyl- 2-oxoglutarate phosphoenol a D-tryptophanyl- an ADP-sugar a D-aspartyl- 34 dehydrogenase: methylguanine [SAMP] C- pyranopterin a RNA-DNA hybrid sec dehydratase: dehydrogenase: Phe carrier protein]- cys an N-terminal aminopeptidase Trp asp D-muramoyl- ser a tRNA a metal MADE_RS07925 diaminopimelate anthranilate PRPP glucosamine N- a 2-thiouridine dioxygenase: arginyl-[protein] [tRNA ] L-aspartate dADP pyruvate [tRNA ] [tRNA ] RS05110 a metal 3-isopropylmalate acyltransferase: lpdA gcvP in DNA terminal glycine phosphate L-cysteine Xaa-L-proline substrate L-alanine(1-) epimerase: dapF met ilvD L-tyrosine biosynthesis I acyltransferase: Kdo transfer to in tRNA MADE_RS05760 a [glycine-cleavage cation cation L-asparagine bifunctional histidinol- dehydratase: lpxD N-Formyl-L- a [glycine-cleavage (3S)-3-methyl-2- lpxD UDP-2-N,3-O-bis[(3R)- lipid IV I (E. coli) tRNA uridine-5- complex H protein] N 6 - ADP biosynthesis I phosphatase/ leuD leuC A kynurenine SAH 6 D-glucopyranose aspartyl/ ribonuclease meso-diaminopimelate oxopentanoate anthranilate UDP-2-N-[(3R)-3- complex H protein] N bifunctional DNA- leucyl/ molybdopterin Xaa-Pro D-tyrosyl- compounds D-tyrosyl- 1,6-anhydro-N- imidazoleglycerol- L-proline 3-hydroxytetradecanoyl]- carboxymethylaminomethyl(34) aminomethyldihydrolipoyl- 6-phosphate asparaginyl beta- IscS subfamily aminopeptidase HII: rnhB serine- 2-oxobutanoate (2R,3S)-3- chorismate phosphoribosyltransferase: trpD hydroxydodecanoyl]- CMP-Kdo lipid IV (E. coli) -dihydrolipoyl-L-lysine phenylalanyl- synthase tRNA(Tyr) tRNA(Tyr) acetylmuramyl- a metal a metal biosynthesis I branched-chain α-D-glucosamine A (R)-NADPHX synthesis enzyme MnmG: mnmG L-lysine formamidopyrimidine cysteine aminopeptidase: pyruvate hydrolase -tRNA phosphate bifunctional bifunctional adenosylhomocysteinase: L-serine degradation tRNA--protein hydroxylase PepB: pepB ribonuclease RS07680 asp isopropylmalate 3-O-[(3R)-3- glycosylase/ catalytic subunit desulfurase: pepP deacylase: dtd NudE: nudE deacylase: L-alanine ligase: cation cation dehydratase diaminopimelate (from L-glutamate) amino acid UDP-2,3- tRNA uridine-5- MADE_RS16020 domain-containing HI: rnhA kinase: pyk acetolactate asparagine 3-isopropylmalate chorismate mutase/ hydroxydecanoyl]- ADP-dependent DNA-(apurinic transferase: MoaE: moaE dtd amidase HisB: hisB decarboxylase: lysA aminotransferase: N-(5-phosphoribosyl)-anthranilate diacylglucosamine 3-deoxy-D-manno- carboxymethylaminomethyl(34) protein: MADE_RS13230 leucyl serS synthase synthase prephenate α NAD(P)H-hydrate L-threonine aat AmpD: ampD glu MADE_RS02090 dehydrogenase: -D-glucosamine diphosphatase: octulosonic acid synthesis GTPase MnmE: mnmE L-kynurenine ser or apyrimidinic [+ 2 isozymes] aminopeptidase: α large subunit: (glutamine- dehydrogenase: dehydratase/ L-homocysteine degradation II MADE_RS05785 a proteinogenic an -D-aldose a metal a metal glutamate 5- leuB bifunctional indole-3-glycerol- UDP-2,3- Chlorinated site) lyase: mutM pepA a peptide a nucleoside 5'- D-tryptophan a tRNA Trp RS16810 histidinol lys tyrA MADE_RS12990 transferase: NAD(P)H-hydrate a 5-carboxymethylaminomethyl- glycine cleavage system serine/threonine a [SAMP] C- amino acid DNA pyruvate 1-phosphate AMP MADE_RS18205 hydrolyzing) kinase: proB phosphate synthase TrpC/ diacylglucosamine L-phenylalanyl-L- molybdopterin dATP asp an L-seryl- cation cation ile (2S)-2-isopropyl- MADE_RS02200 34 kynureninase: aminomethyltransferase dehydratase: Compound Degradation a [ThiI sulfur- monophosphate tRNA D-aspartate N-acetyl-D- : asnB prephenate UDP-2,3- epimerase: 2-thiouridine in tRNA a tRNA Phe terminal glycine a [protein]- [tRNA sec ] acetolactate histidinol glutamate 5- 3-oxosuccinate phosphoribosylanthranilate diphosphatase: thr arginyl-[protein] L-phenylalanine diacylglucosamine kynU GcvT: gcvT 2-aminoprop-MADE_RS16755 a [DNA]- a 5'-phospho- 2,6-diamino-4- 3-hydroxy- succinate ala carrier protein]- a peptide with ala muramate synthase: asparagine isomerase TrpF: trpCF MADE_RS12990 α MADE_RS18265 L-threonine 3- 1,2-dichloroethane 4-oxo-2-pentenal a proteinogenic dehydrogenase: hisD γ-L-glutamylkinase: proB bifunctional -Kdo-(2->6)- protein S-nitrosylation nucleotide- hydroxy-5-(N-methyl) L-aspartate S-sulfanyl- biosynthesis I diphosphatase: lpxH (S)-NADPHX dehydrogenase: 2-enoate [DNA] an N-terminal a metal a metal MADE_RS02655 synthase chorismate mutase/ 1-(2-carboxyphenylamino)-1- UDP-2,3- lipid IV (E. coli) and denitrosylation anthranilate degradation 3'-phosphate formamidopyrimidine L-cysteine amino acid RS19520 5-phosphate A L-asparagine L-proline cation cation ilvN B: asnB histidinal deoxy-D-ribulose 5-phosphate a 5-aminomethyl-2- tdh chorismate prephenate diacylglucosamine lipid X KDO transferase: bifunctional a [protein]- L-2-amino-3- asn glutamate-5- 4-methyl-2- 34 degradation I 1,2-dichloroethane (S)-2-aceto-2- alanine dehydrogenase: diphosphatase: lpxH ADP-dependent thiouridine in tRNA L-glutamine L-aspartate bifunctional semialdehyde bifunctional indole-3-glycerol- MADE_RS02200 L-cysteine oxobutanoate haloalkane a 7,8-dihydro- an N-terminal- an N-terminal- histidinol oxopentanoate lipid-A- degradation I an N-terminal a cytosine 32 an [L-cysteine an sn-glycero-3- a 3-(acyloxy) a peptide with N-β-aspartyl- a supercoiled hydroxybutanoate racemization tyrA phosphate synthase TrpC/ α NAD(P)H-hydrate tRNA 2- degradation I an L-phenylalanyl- a pimeloyl-[acp] a D-tyrosyl- 34 chorismate mutase/ dehydrogenase: disaccharide -Kdo-(2->4)- glycine C- 2-iminopropanoate dehalogenase: 8-oxoguanine desulfurase]-S- phospho-N-(acyl) acyl group of L-methionyl-L- L-methionyl-L- a cytidine lys a metal a metal dehydrogenase: hisD branched-chain lipid X (P. putida) asn L-lysyl-[protein] Phe in tRNA SAH an N-terminal L-arginine Tyr duplex DNA ketol-acid 3-(4- phosphoribosylanthranilate α dehydratase/ thiouridine(34) [tRNA ] methyl ester [tRNA ] Ile2 prephenate MADE_RS09315 synthase: lpxB -Kdo-(2->6)- L-phenylalanine acetyltransferase: MADE_RS08575 in DNA sulfanyl-L-cysteine ethanolamine bacterial toxin threonyl-[protein] alanyl-[protein] in tRNA replicative cation cation amino acid NAD(P)H-hydrate isoaspartyl L-proline RS07350 reductoisomerase: dehydrogenase: ala hydroxyphenyl) isomerase TrpF: trpCF lipid-A- lipid IV (E. coli) synthase MADE_RS00320 gln asp 2-chloroethanol his L-glutamate-5- aminotransferase: lipid A disaccharide A a [protein] 3- degradation peptidase/L- DNA ilvC tyrA alanine pyruvate (1S,2R)-1-C-(indol-3- disaccharide epimerase: MnmA: mnmA imidazole isoaspartyl ala ala L-alanine semialdehyde MADE_RS02090 (E. coli) nitrosothio- I (aerobic) asparaginase: aspartate/ bifunctional DNA- leucyl/ tRNA 2- glycerophosphodiester 5'-methylthioadenosine/ acyloxyacyl type I methionyl pimeloyl-ACP type I methionyl D-tyrosyl- tRNA helicase: (R)-2,3-dihydroxy- prephenate racemase: aspartate/ synthase: lpxB MADE_RS18265 gly glycerol prolyl peptidase/L- yl)glycerol 3-phosphate tetraacyldisaccharide a 5-methylaminomethyl- L-alanine MADE_RS08280 tyrosine/aromatic phenylalanyl- thiocytidine(32) aminopeptidase: aminopeptidase: dnaB biosynthesis III tyrosine/aromatic 34 phosphate formamidopyrimidine phosphodiesterase: S-adenosylhomocysteine hydrolase: methyl ester tRNA(Tyr) lysidine(34) alginate RS18745 alginate 3-methylpentanoate alr lipid A 2-thiouridine in tRNA phe aminotransferase: pyruvate tRNA--protein synthetase aminopeptidase: pip asparaginase: prephenate leu aminotransferase: tryptophan 4'-kinase: NADPH asparaginase: synthase: glycosylase/ MADE_RS02600 nucleosidase: MADE_RS07690 map esterase map deacylase: synthetase ATP- dihydroxy-acid D-ala disaccharide phenylalanine 4- MADE_RS11050 transferase: TtcA: ttcA MADE_RS08280 cys dehydratase: MADE_RS11050 synthase: trpA trpB MADE_RS09515 ansA hisH hisF DNA-(apurinic glycerophosphodiester MADE_RS03860 acyloxyacyl BioH: bioH dtd TilS: tilS dependent dehydratase: (P. putida) monooxygenase: oxaloacetate chloroacetaldehyde aat cysteine pheA (S)-1-pyrroline- asp or apyrimidinic phosphodiesterase: glpQ [+ 2 isozymes] hydrolase: helicase ilvD L-glutamate biosynthesis III ser tetraacyldisaccharide lipid IV (E. coli) MADE_RS05725 [+ 7 isozymes] 32 an [L-cysteine an N-terminal L- an N-terminal L- alginate RS12315 alginate tyr A a 2-thiocytosine a peptide pro 5-carboxylate indole a 5-methylaminomethyl- a [protein]- site) lyase: mutM MADE_RS00180 met 34 HrpB: hrpB desulfurase: 3-phenyl-2- 4'-kinase: S-nitrosoglutathione tyr L-glutamine L-glutamate glu desulfurase]- threonyl-[protein] met alanyl-[protein] arg asp a lysidine (3S)-3-methyl-2- in tRNA MeOH Tyr a single MADE_RS13210 oxopropanoate 2-(S-geranyl) L-cysteine L-phenylalanyl- a pimeloyl-[acp] D-tyrosine a tRNA Ile2 pyrroline-5- MADE_RS09515 degradation II degradation I L-alanine Phe in tRNA oxopentanoate 2-oxoglutarate Chemoautotrophic 34 a tRNA L-cysteine sn-glycerol an N- stranded DNA [+ 2 isozymes] carboxylate thiouridine in tRNA S-(hydroxymethyl) a [DNA]- L-lysyl-[protein] S-ribosyl-L- a 3-hydroxyacyl NADP-specific glutamate aspartate/ tryptophan lipid IV degradation IV a 5'-phospho- 7,8-dihydro- 3-phosphate acylethanolamine adenine branched-chain ala A Energy Metabolism 2-chloroacetate 4-oxo-2-pentenal homocysteine alginate RS03595 alginate tyrosine/aromatic reductase: synthase: trpA trpB (P. putida) Aromatic Compound Biosynthesis glutathione glu nucleotide- [DNA] 8-oxoguanine group of a fatty acid amino acid dehydrogenase: gdhA gln aminotransferase: MADE_RS15095 dehydrogenase/ glutamate ala 3'-phosphate bacterial toxin aminotransferase: glutamate synthase hydrogen NAD-glutamate haloacid MADE_RS11050 a 5-methylaminomethyl- class III alcohol synthase large chorismate biosynthesis I oxidation dehydrogenase: alanine dehalogenase 2+ 2+ MADE_RS02090 large subunit: gltB pro trp 3-(4-hydroxyphenyl) 2-(Se-phospho) dehydrogenase: Mg Mg I (aerobic) subunit: gltB MADE_RS10100 type II: di-trans,octa-cis UDP-N-acetyl- a [protein chain β-D-fructofuranose an N-acylated an N-terminal- (E)-4-hydroxy-3- N-acetyl-L- 2+ ApaG 2+ glu 34 dehydrogenase: ald an (R)-2- (2E,6E)-farnesyl a [DNA]-3'- a 5'-phospho- Co Co phe Polyprenyl pyruvate biosynthesis selenouridine in tRNA MADE_RS15225 glu 2-oxoglutarate -undecaprenyl α ala a pimeloyl-[acp] 3-methylbutanoate β L-methionyl-L- methylbut-2-en- NADH acetyl-CoA ile D-erythrose H pyruvate MADE_RS01995 -D-muramoyl- halocarboxylate protoheme (R)- -lysine elongation factor 1-phosphate aliphatic-L- hydroxyl [DNA] glutamate 5- 2 phospho-N- diphosphate Biosynthesis 4-phosphate S-(hydroxysulfenamide) phosphate L-alanyl-γ-D- P]-L-lysine 34 amino acid seryl-[protein] 1-yl diphosphateflavodoxin- acetyl-CoA semialdehyde 3-deoxy-7- hydrogenase glycolate acetylmuramoyl- N-acetyl- tyr glutathione 2+ 2+ small subunit: pentapeptide- glutamyl-meso-2,6- dependent carboxylase Co Co octaprenyl phosphoheptulonate a 5-methylaminomethyl- acetate- HAD family fructose cisplatin damage NAD(+) gamma- CorC aspartate/ MADE_RS01640 diaminopimeloyl- 8-amino-7- protoheme IX elongation type I methionyl (E)-4-hydroxy- carboxyl Mg 2+ Mg 2+ diphosphate synthase: 34 transferase: mraY -CoA hydrolase: bisphosphate acylase: response ATP- diphosphatase: glutamyl- tyrosine/aromatic 2-selenouridine D-alanyl-D-alanine oxononanoate farnesyltransferase: aminopeptidase: 3-methylbut- transferase biosynthesis MADE_RS06485 A(H2) ligase: acs MADE_RS08610 factor P--(R) aldolase: MADE_RS09695 dependent nudC phosphate Nucleoside and Nucleotide Biosynthesis aminotransferase: in tRNA Fatty Acid and Lipid Degradation MADE_RS18955 map subunit synthase: -beta-lysine MADE_RS04295 DNA ligase: 2-enyl- reductase: (2E,6E)-farnesyl 3-deoxy-7- 3-(4- MADE_RS11050 hydroxylamine HAD family alpha: accA IPP MADE_RS06820 protoheme IX ligase: epmA diphosphate 2+ 2+ hydrolase: MADE_RS18145 reduced β- argC Mg RS00950 Mg superpathway of pyrimidine diphosphate phosphoheptulonate hydroxyphenyl) oleate β-oxidation 3-methylbutanoyl- farnesyltransferase: synthase: ispG [+ 3 isozymes] N-acetylglutamyl- pyrimidine deoxyribonucleotides de novo biosynthesis I 5-aminoimidazole ribonucleotide biosynthesis I β diphosphate MADE_RS02010 an aliphatic a carboxylate an N-terminal 2-C-methyl-D- nicotinamide D- ribonucleotides de novo biosynthesis superpathway of superpathway of pyrimidine pyrimidine synthase class II: pyruvate fatty acid -oxidation I (generic) AMP CoA MADE_RS19450 D-glyceraldehyde AMP phosphate undecaprenyldiphospho- UMP (8S)-8-amino-7- [a protein chain DHAP L-amino acid met L-seryl-[protein] erythritol-2,4- ribonucleotide malonyl-CoA adenosine nucleotides nucleobases salvage ribonucleosides salvage I octaprenyl 3-deoxy- MADE_RS06855 UDP CTP oleate N-acetylmuramoyl-L- oxononanoate acyl-carrier protein elongation factor [DNA] cyclodiphosphate de novo biosynthesis I diphosphate Mg 2+ MgtE Mg 2+ gln PRPP uracil cytidine D-arabino- Glycolysis a (3Z)-alk-3-enoyl-CoA alanyl-γ-D-glutamyl-meso an (S)-2- EF-P]-N-(β-L- hydrogencarbonate ribonucleoside- synthase: ispB ammonium a halide anion uracil heptulosonate long-chain- hydroxycarboxylate ferroheme o 34 diphosphate -2,6-diaminopimeloyl- lysyl)-L-lysine IMP phosphoribosyltransferase: upp 7-phosphate fatty-acid-- ∆ 3 ∆ 2 asp reductase: nrdA nrdB CDP amidophosphoribosyltransferase: purF cytidine uridine all-trans- glycolysis III (from glucose) -cis- -trans- D-alanyl-D-alanine UMP CoA ligase kinase: udk enoyl-CoA + + glutamine- dUDP ribonucleoside- deaminase: octaprenyl 3-dehydroquinate Na RS10060 Na 5-phospho-β- FadD: fadD isomerase: hydrolyzing diphosphate gly cdd diphosphate synthase: aroB a 2'- a [protein] N- a peptidoglycan an N-terminal- adenylosuccinate nucleoside- UMP kinase: pyrH D-glucopyranose an N 10 - an (S)-2- a peptide with carbamoyl- D-ribosylamine CMP tRNA processing fadJ 34 an L-methionyl- a ferrocytochrome stearoyl-CoA an N-acyl- diphosphate kinase: ndk reductase: nrdA nrdB oleoyl-CoA a 5,10-gly a uridine 5'-deoxyadenosine deoxyribonucleoside terminal-formyl- dimer (S. aureus) L-methionyl-L- an N-terminal trp a protein phosphate synthase: uridine 3-dehydroquinate [initiator tRNA Met ] formyltetrahydrofolate b halocarboxylate [DNA] L-aspartate ATP UDP glucokinase: fatty acid methylenetetrahydrofolate in tRNA 5 5'-triphosphate L-methionine valyl-[protein] + + MADE_RS02800 dUTP dCDP RNA L-alanine tryptophan 7- carboxy Na RS16645 Na synthase: uridine type II 3- glk a polycistronic acyl-CoA a (2E)-2-enoyl-CoA oxidation nucleoside- fatty acid penicillin- halogenase: terminal- carA carB dUTP diphosphatase: nucleoside- kinase: udk dehydroquinate tRNA precursor dehydrogenase: complex HAD family 5'-methylthioadenosine/ diphosphate kinase: ndk D-glucopyranose tRNA uridine-5- methionyl-tRNA acyl-CoA group II peptide binding type I methionyl MADE_RS09625 processing MADE_RS11440 diphosphate kinase: ndk dehydratase: aroQ MADE_RS13750 oxidation subunit alpha hydrolase: S-adenosylhomocysteine aspartoacylase: polynucleotide aminopeptidase superpathway of adenylo-succinate GAR UMP 6-phosphate a 2,3,4-saturated (3R carboxymethylaminomethyl(34) formyltransferase: desaturase: intron reverse deformylase: protein aminopeptidase: peptidase: carbamoyl UTP [+ 2 isozymes] a 2,3,4-saturated long-chain- complex MADE_RS08610 nucleosidase: MADE_RS14805 N: pepN tryptophan 7- NADH:ubiquinone asp guanosine nucleotides nucleoside triphosphate dCTP glucose-6- ribonuclease acyl-CoA FadJ: fadJ )-3-hydroxyacyl-CoA MADE_RS05990 transcriptase/ MADE_RS00100 map adenylyltransferase fatty-acid-- subunit alpha synthesis enzyme MnmG: mnmG MADE_RS05360 2: mrdA prc + + phosphate adenylosuccinate pyrophosphohydrolase: 3-dehydroshikimate E: rne (2E,9Z)- fatty acid HAD family MADE_RS03860 PcnB: pcnB halogenase: Na reductase (Na(+) Na de novo biosynthesis I phosphoribosylglycinamide CTP synthase: phosphate dehydrogenase [+ 3 isozymes] maturase: ltrA lyase: purB CoA ligase FadJ: fadJ tRNA uridine-5- hydrolase: [+ 2 isozymes] MADE_RS18915 a peptide -transporting) mazG formyltransferase: purN MADE_RS04635 shikimate isomerase: pgi ribonuclease octadecenoyl-CoA FadE: fadE [+ 3 isozymes] 7-chloro-L- a tRNA precursor FadD: fadD a 2,3,4-saturated a 2,3,4-saturated (3S carboxymethylaminomethyl(34) MADE_RS02010 an N-terminal L- a carboxylate a peptidoglycan an N-terminal aspartate IMP CTP dehydrogenase: E: rne fatty acid [+ 2 isozymes] a ferricytochrome oleoyl-CoA formate asp ala a peptide tryptophan dUMP guanine and with a 5' fatty acyl CoA )-3-hydroxyacyl-CoA synthesis GTPase MnmE: mnmE an N-formyl- methionyl-[protein] with D,D cross- D-ala met L-valyl-[protein] carbamoyltransferase: FGAR F6P ribonuclease oxidation fatty acid b RNA + + AMP guanosine salvage II aroE L-methionyl- a tetrahydrofolate 5 5-deoxy-D-ribose link (S. aureus) Na OadA Na MADE_RS02310 thymidylate synthase: extension and R: rnr IMP complex oxidation met an (S)-2- adenine [DNA] MADE_RS03325 phosphoribosylformylglycinamidine ATP-dependent 6- a long 3' trailer 34 [initiator tRNA ] a halide anion shikimate ribonuclease subunit alpha complex a 5-carboxymethylaminomethyluridine hydroxycarboxylate dehydrogenase: synthase: purL phosphofructokinase: a 7,8-dihydrofolate adenylate dTMP guanosine D: rnd a tRNA precursor FadJ: fadJ coenzyme A subunit alpha in tRNA N-carbamoyl- guaB shikimate MADE_RS09815 kinase: adk with a 5' FadJ: fadJ a sugar RS18435 a sugar L-aspartate dTMP kinase: β ribonuclease (S)-3-hydroxy-(9Z) FGAM kinase -D-fructose 1,6- extension and a acetyl-CoA C- XMP MADE_RS08525 R: rnr -octadecenoyl-CoA a 2,3,4-saturated a 2,3,4-saturated a purine base a nascent peptidoglycan a peptidoglycan N-acetyl-D- an N-terminal- a peptide with ADP AroK: aroK bisphosphate short 3' extension acyltransferase 3-phenyl-2- an (R)-2- (R)-S- dihydroorotase: ribonuclease fatty acyl CoA 3-oxoacyl-CoA tyr 2-methylbutanoate with (L-alanyl-γ-D-glutamyl- dimer (generic) galactosamine a tRNA precursor L-methionyl- an N-terminal glu ala (R)-lactate dTDP phosphoribosylformylglycinamidine guanine shikimate 3- ribonuclease ribonuclease fatty acid FadA: fadA lesion in DNA oxopropanoate halocarboxylate lactoylglutathione dGDP pyrC D: rnd 6-phosphate glycyl-[protein] L-methionine D-2-hydroxyacid a sugar RS18450 a sugar glutamine- ribonucleoside- cyclo-ligase: purM fructose D: rnd PH: rph oxidation triacylglycerol meso-2,6-diaminopimeloyl-D- nucleoside- phosphate [+ 2 isozymes] ribonucleoside- hydrolyzing GMP diphosphate complex degradation alanyl-D-alanine) pentapeptide dehydrogenase: (S)-dihydroorotate hypoxanthine 3-phosphoshikimate 1- bisphosphate bifunctional DNA- acetate- HAD family membrane-bound lactoylglutathione diphosphate synthase: guaA reductase: diphosphate kinase: ndk AIR subunit alpha aspartate/ N-acetylglucosamine- type I methionyl type I methionyl glutamate-- MADE_RS15585 phosphoribosyltransferase: aldolase: a tRNA precursor a triacyl-sn formamidopyrimidine -CoA hydrolase: lytic murein ribonuclease lyase: reductase: nrdA nrdB dTTP carboxyvinyltransferase: a tRNA FadJ: fadJ tyrosine/aromatic 6-phosphate aminopeptidase: cysteine ligase: D-2-hydroxyacid quinone- MADE_RS08130 MADE_RS04295 ligase: acs transglycosylase D: rnd aminopeptidase: a sugar RS14060 a sugar aroA precursor with with a short -glycerol glycosylase/ aminotransferase: penicillin-binding MADE_RS08610 MADE_RS12115 dehydrogenase: nrdA nrdB GMP xanthine and 3-oxo-(9Z)- triacylglycerol MltF: mltF deacetylase: nagA map map MADE_RS06035 dependent 5-enolpyruvoyl- a 5' extension 3' extension acetyl-CoA DNA-(apurinic MADE_RS11050 protein 2: mrdA HAD family [+ 2 isozymes] octadecenoyl-CoA lipase: MADE_RS19580 GDP dihydroorotate dADP xanthosine salvage GMP shikimate 3- or apyrimidinic (2S)-2- hydrolase: [+ 3 isozymes] triose-phosphate MADE_RS18185 Carbohydrate Degradation pyruvate dehydrogenase: phosphate ribonuclease ribonuclease acetyl-CoA C- methylbutanoyl- D-galactosamine a nucleoside 5'- γ-L-glutamyl- 2+ 2+ guanylate isomerase: a 1,2-diacyl- site) lyase: mutM 3-(4- AMP diphosphate MADE_RS02010 acetate an N-terminal Cd CadA Cd nucleoside- D: rnd a nascent peptidoglycan 6-phosphate a tRNA met met a peptide pyrD kinase: gmk superpathway of pyrimidine deoxyribonucleoside salvage adenine and chorismate MADE_RS09240 PH: rph acyltransferase: sn-glycerol hydroxyphenyl) phe CoA GlcNAc-1,6- monophosphate glutathione methylglyoxal glycyl-[protein] D-alanine xanthosine D-glyceraldehyde Entner-Doudoroff pathway I with (L-alanyl-γ-D-glutamyl- D-ala a lipid II PRPP diphosphate adenosine salvage III synthase: DHAP MADE_RS08585 pyruvate anhydro-MurNAc- orotate 3-phosphate lactose degradation II a [DNA]- a 5'-phospho- a modified meso-2,6-diaminopimeloyl- a (2R)-2- kinase: ndk 2'-deoxycytidine pyrimidine/purine aroC [+ 2 isozymes] Secondary Metabolite Degradation nucleotide- 4-oxo-2-pentenal a halide anion pentapeptide GDP nucleoside type I D-glucopyranose [DNA] nucleobase D-alanine) tetrapeptide hydroxy fatty acid fluoride CrcB fluoride orotate an uncharged α-lactose 3'-phosphate dATP cytidine adenine phosphorylase: chorismate glyceraldehyde- (7Z)-hexadecenoyl-CoA 6-phosphate phosphoribosyltransferase: adenine and adenosine salvage I tRNA a 2-acylglycerol anhydromuropeptides recycling I deaminase: cdd pyrimidine/purine MADE_RS05595 3-phosphate glucose-6- pyrE xanthine acyl-CoA β nucleoside- ribonucleoside- nucleoside phosphorylase: dehydrogenase: GlcNAc-1,6- phosphate a [ribosomal quinoxaline-2- an N-acetyl- - N-acetyl-muramoyl-(L- a 3,5,7,9,11,13,15- D-sedoheptulose a [protein]- dCMP dehydrogenase: a sulfurated glycerophosphoserine an alkylmercury ADP-D-ribose γ lipid A MsbA lipid A diphosphate 3'-ketolactose protein S12] aryl-carrier protein DL-allothreonine D-hexosaminide alanyl-γ-D-glutamyl-L- hepta-oxo- asp O-ureido-L- 1,7-bisphosphate -L-glutamyl- gly L-tyrosine diphosphate 2'-deoxyuridine MADE_RS05595 gap anhMurNAc- dehydrogenase: [sulfur carrier] carboxyl adenylate XTP orotidine 5'- (d)CMP adenosine MADE_RS13750 L-aspartate 89 lysyl-D-alanyl-D-alanine) hexadecanoyl-[PKS-acp] homoserine D-alanine polysaccharide kinase: ndk reductase: adenosine glyceraldehyde- L-Ala-γ-D-Glu- zwf aldo/keto kinase: cmk [+ 2 isozymes] beta-glucosidase: inosine/ phosphate nrdA nrdB thymidine kinase: pyrimidine/purine 5-(methoxycarbonylmethoxy) glycerol DAP-D-Ala 6-phospho reductase: ADP-ribose biosynthesis 3-phosphate MADE_RS18440 glycerophosphodiester beta- organomercurial fructose xanthosine MADE_RS13790 adenosine deaminase: nucleoside phosphorylase: uridine biosynthesis (2E,7Z)- D-glucono- serine penicillin- MADE_RS17085 argininosuccinate diphosphatase: glutathione tyrosine predicted orotidine-5'- dCDP dehydrogenase: β 30S ribosomal acyl carrier hexosaminidase: lyase MerB: merB bisphosphate MADE_RS07775 MADE_RS05595 hexadecenoyl-CoA 3-keto- -D- phosphodiesterase: autokinase: triphosphatase: GTP thymidine XMP MADE_RS11600 1,6-anhydro-N- 1,5-lactone protein S12 hydroxymethyltransferase: MADE_RS02830 binding aldo/keto synthase: nudF synthase: ABC phosphate nucleoside- adenine galactose protein: acpP MADE_RS02600 organomercurial aldolase: MADE_RS07920 yjjX urea urea dUMP adenosine deaminase: add fatty acid acetylmuramyl- methylthiotransferase MADE_RS12745 protein reductase: MADE_RS02510 gshB transporter decarboxylase: dGDP diphosphate prephenate SAM 6-phosphogluconolactonase: beta-N- lyase MerB: merB MADE_RS04295 a [protein]- oxidation L-alanine glycerophosphodiester 2: mrdA XDP of urea pyrF thymidine kinase: 13-DPG pgl RimO: rimO acetylhexosaminidase: 9-hydroxy-3,5,7,11,13,15-MADE_RS18080 D-ribofuranose L-tyrosine thymidylate kinase: ndk complex phosphodiesterase: glpQ nucleoside- inosine adenine amidase a quinoxaline-2- nagZ hexaoxohexadecanoyl- 5-phosphate phosphate UMP synthase: MADE_RS13790 guanine and D-gluconate acetaldehyde canavaninosuccinate D-erythrose AMP norophthalmate diphosphate dCTP phosphoribosyltransferase: apt phosphoglycerate carboxy-S- subunit alpha AmpD: ampD AMP carboxyl-[aryl- gly N-acetyl-muramoyl-(L- 2+ DHAP thiol CydD thiol MADE_RS03325 guanosine salvage 6-phosphate D-galactopyranose a [ribosomal [PKS-acp] an alkane Hg 4-phosphate pyrimidine/purine kinase: FadJ: fadJ 5'-deoxyadenosine an unsulfurated carrier protein] γ UMP kinase: ndk adenosyl-L- met protein S12]-3- sn-glycerol an N-acetyl-β- alanyl- -D-glutamyl- D-ala nucleoside phosphorylase: MADE_RS04290 N-acetyl-β-D- L-alanyl-γ-D- phosphogluconate [sulfur carrier] ser kinase: methionine (S)-3-hydroxy-(7Z) methylsulfanyl- 3-phosphate an alcohol D-hexosamine L-lysyl-D-alanine) CMP MADE_RS05595 AMP Carbohydrate Biosynthesis glucosamine-1,6- glutamyl-meso-2,6- dehydratase: pyrH dGTP guanosine synthase -hexadecenoyl-CoA 89 2+ 2+ phosphorylation 3-phospho-D-glycerate MADE_RS11655 L-aspartate Hg RS05050 Hg pyrimidine/purine CmoA: cmoA anhydro-N-acetyl- diaminopimeloyl- UDP dTMP fatty acid β CMP hypoxanthine gluconeogenesis I -D-muramate D-alanine nucleoside phosphorylase: UDP-N-acetyl-D- UDP-α-D-glucose oxidation 4 CMP-pseudaminate dTDP-β-L-rhamnose 2,3- KDGP 34 an O - D-sedoheptulose a 5- S-adenosyl-S- beta- a 5,10- a 2-thiouridine a single a [protein]- 37 a D-aminoacyl- nucleoside- (d)CMP dTMP kinase: MADE_RS05595 glucosamine biosynthesis I biosynthesis biosynthesis diphosphoglycerate- complex a (6S)-5- DMAPP an adenosine fumarate γ-L-glutamyl-(S)- a uracil in DNA DHAP AIR biosynthesis 34 hexosaminidase: methylenetetrahydrofolate in tRNA stranded DNA L-cysteine methylthymine glu asp gly 1-phosphate a mercapturate a reduced diphosphate kinase: cmk MADE_RS08525 hypoxanthine guanine (S)-malate hydroxyuridine carboxymethyl- in tRNA [tRNA] ITP D-glucopyranose α D-glucopyranose dependent subunit alpha in DNA formyltetrahydrofolate 2-aminobutanoate NAD(P)H- 5-(carboxyamino) H O c-type CDP phosphoribosyltransferase: UDP-N-acetyl- -D-glucosamine α in tRNA L-homocysteine queuosine biosynthesis I (de novo) MADE_RS02830 γ 2 kinase: ndk dTDP -D-glucopyranose FadJ: fadJ L-alanyl- -D- bifunctional inosine/ cytochrome gln MADE_RS08130 6-phosphate UDP-N- 6-phosphate phosphoglycerate dependent imidazole cytochrome nucleoside- hypoxanthine glucose-6- 1-phosphate alpha-D-glucose beta-N- glutamyl-meso- 4-hydroxy-2- tRNA uridine-5- exodeoxyribonuclease uracil-DNA fructose xanthosine c oxidase an oxidized UTP glucose-1-phosphate mutase: gpmA 3-oxo-(7Z)- methylated-DNA-- tRNA (adenosine(37)-N6) L-aspartate glutathione glycerol-3- ribonucleotide nucleoside- phosphoribosyltransferase: phosphate acetylglucosamine phosphate-specific tRNA 5- acetylhexosaminidase: diaminopimelate bifunctional D-tyrosyl- glycosylase: bisphosphate O c-type diphosphate preQ oxoglutarate carboxymethylaminomethyl(34) VII small subunit: xseB oxidase: acylase: triphosphatase: 2 thymidylyltransferase 0 hexadecenoyl-CoA [protein]-cysteine S- -dimethylallyltransferase synthase: phosphate synthase: diphosphate IMP MADE_RS08130 isomerase: pgi 4,6-dehydratase phosphoglucomutase: methoxyuridine(34) nagZ tetrahydrofolate tRNA(Tyr) ung aldolase: cytochromea reduced CTP synthase: kinase: ndk malate 2-phospho-D-glycerate NADPH-dependent 7- aldolase/2- synthesis enzyme MnmG: mnmG exodeoxyribonuclease methyltransferase: nadB MADE_RS09695 dehydrogenase: MADE_RS02745 yjjX kinase: ndk F6P (inverting): pseB RfbA: rfbA /uridine 5-oxyacetic acetyl-CoA C- synthase/ MiaA: miaA deacylase: gshB H O c-type MADE_RS04635 α MADE_RS07550 cyano-7-deazaguanine 1,6-anhydro-N- dehydro-3-deoxy- tRNA uridine-5- VII large subunit: xseA MADE_RS04295 2 cytochrome CTP dehydrogenase: UDP-2-acetamido-2,6-dideoxy- dTDP- -D-glucose acid(34) synthase acyltransferase: MADE_RS18870 dihydrofolate dtd gpsA N5-CAIR IDP cytochrome dTTP GMP β [+ 2 isozymes] phosphopyruvate reductase QueF: queF acetyl-β-muramate phosphogluconate carboxymethylaminomethyl(34) uracil c oxidase an oxidized mdh glutamine-- -L-arabino-hex-4-ulose dTDP-glucose 4,6- α-D-glucopyranose CmoB: cmoB MADE_RS08585 synthase: folC N 6 -(3-methylbut- an apyrimidinic sn-glycerol CTP hydratase: eno preQ anhydro-N- aldolase: synthesis GTPase MnmE: mnmE 2-iminosuccinate succinate acetate an L-cysteine- O c-type malate fructose-6- UDP-4-amino-4, 6- dehydratase: rfbB 1-phosphate 1 a ribonucleoside a single-stranded a [protein]-S- 2-en-1-yl)- ophthalmate site in DNA D-erythrose 3-phosphate 2 [+ 2 isozymes] N-acetylglucosamine MADE_RS11645 a thymine in DNA DHAP S-conjugate cytochromea reduced malate dideoxy-N-acetyl- acetylmuramic oligodeoxyribonucleotide 37 an uncharged dehydrogenase: phosphate dTDP-4-dehydro-6- UTP--glucose- phosphoenolpyruvate a 5-(carboxymethoxy) tRNA guanosine(34) degradation I 5'-monophosphate methyl-L-cysteine adenosine a D-amino acid H O c-type acid kinase: a (6S)-5- tRNA 2 cytochrome- MADE_RS17745 dehydrogenase, transaminase beta-L-altrosamine deoxy-α-D-glucopyranose 1-phosphate uridine 34 in tRNA (5Z)-tetradecenoyl-CoA bifunctional a 5-aminomethyl-2- in tRNA transglycosylase Tgt: tgt MADE_RS15555 N-acetyl-D- a 7,8-dihydrofolate formyltetrahydrofolate c oxidase, cytochromean oxidized NAD-requiring: (isomerizing) transaminase: pseC dTDP-4- uridylyltransferase pyruvate 4-hydroxy-2- thiouridine 34 in tRNA MADE_RS17745 a 7-aminomethyl-7- acyl-CoA N-acetyl-D- glucosamine O cbb3-type c-type Fatty Acid and Lipid Biosynthesis : glmS UDP-4-amino-4,6-dideoxy- dehydrorhamnose GalU: galU kinase: pyk oxoglutarate 2 N-acetyl-β-L-altrosamine deazaguanosine 34 in tRNA dehydrogenase: muramate 6- 6-phosphateN-acetylglucosamine- nitrate RS18800 nitratecytochrome D-glucosamine 3,5-epimerase: rfbC aldolase/2- D-galactose degradation I (Leloir pathway) 6 UDP-α-D-glucose a 5-(methoxycarbonylmethoxy) tRNA preQ1(34) S- MADE_RS11075 phosphate 6-phosphate UDP-N-acetyl- a [protein]- an O - N,N',N''- a 2'- a 1-acyl-2- a dietary all- a triacyl-sn a dipeptide with a RNase II poly-A palmitate biosynthesis 6-phosphate dTDP-4-dehydro- pyruvate dehydro-3-deoxy- di-trans,octa-cis- α a ferrocytochrome palmitoyl-CoA ammonium NAD + H O carbonic acid oleate biosynthesis oxaloacetate 34 [+ 2 isozymes] N-acetylmuramic D-glucosaminedeacetylase: nagA -D-glucosamine methylguanine triacetylchitotriose deoxyribonucleoside arachidonoyl- trans-retinyl ester 2 -glycerol C-terminal L-proline (5Z)-dodecenoate stearate biosynthesis biotin-carboxyl carrier β-L-rhamnose uridine in tRNA adenosylmethionine phosphogluconate undecaprenyl phosphate b L-cysteine [DNA] substrate mRNA GTP IMP (type II fatty acid synthase) phosphoglucosamine acid 6- β-D-galactopyranose 5 in DNA 5'-triphosphate sn-glycerol IV (anaerobic) biosynthesis I II (bacteria and plants) protein assembly pyruvate UDP-2,4-diacetamido-2,4,6- ribosyltransferase- (2E,5Z)- 6-phosphate aldolase: eda mutase: glmM dTDP-4- phosphate 3-phosphate CTP diguanylate sulfite RS00420 sulfite trideoxy-β-L-altropyranose isomerase QueA: queA tetradecenoyl-CoA galactose beta-N- triacylglycerol nitrite triacylglycerol carbonic GMP/IMP a (3R)-3- a (3R)-3- Secondary Metabolite Biosynthesis phosphoenolpyruvate dehydrorhamnose etherase: murQ methylated-DNA-- Xaa-Pro an acetoacetyl-[acp] a [biotin carboxyl- α-D-glucosamine mutarotase: UDP-N-acetylglucosamine-- acyl-CoA acetylhexosaminidase: DNA polymerase ribonuclease cyclase: nucleotidase: hydroxydecanoyl- a palmitoyl-[acp] carboxykinase: phosphoenolpyruvate Pentose Phosphate Pathways 34 D-glyceraldehyde lipase: reductase: lipase: dipeptidase: anhydrase: hydroxydodecanoyl-[acp] reductase: rfbD ∆ 3 2 N-acetyl-D- [protein]-cysteine S- carrier protein]-L-lysine 1-phosphate an epoxyqueuosine in tRNA -cis-∆ -trans- fatty acid pyruvate MADE_RS01100 undecaprenyl-phosphate N- desaturase: nagZ III subunit chi: phosphatidate R: rnr MADE_RS04810 yrfG bifunctional 3- [acp] bifunctional 3- beta-ketoacyl- MADE_RS19185 synthase: ppsA glucosamine α-D-glucosamine 3-phosphate MADE_RS18185 nirB nirD MADE_RS18185 pepQ MADE_RS05610 bifunctional biotin- methylerythritol phosphate pathway I dTDP-β-L-rhamnose enoyl-CoA oxidation acetylglucosaminephosphotransferase: wecA MADE_RS05990 methyltransferase: MADE_RS15750 cytidylyltransferase: [+ 14 isozymes] hydroxydecanoyl- hydroxydecanoyl- ACP synthase preQ biosynthesis bifunctional UDP-N- 2,4-diacetamido-2,4,6- pentose phosphate pathway tRNA 6-phosphate 6-phosphate type I α beta- -[acetyl-CoA- 0 complex -D-galactopyranose MADE_RS18870 [+ 10 isozymes] MADE_RS04905 c-di-GMP inosine ACP dehydratase/ ACP dehydratase/ I: fabB acetylglucosamine trideoxy-β-L-altropyranose epoxyqueuosine(34) isomerase: hexosaminidase: RNase II D-glyceraldehyde phosphoenolpyruvate N-acetylglucosamine- glyceraldehyde- a diacyl-sn trans-2- carboxylase] diphosphorylase/ fadJ subunit alpha N-acetyl-α-D- UMP all-trans-retinol a fatty acid nitrite a fatty acid a proteinogenic substrate with CO H O trans-2- pyruvate D-glucopyranose reductase QueG: queG 6-phosphate MADE_RS02830 pro 2 2 a (3R)-3- beta-ketoacyl- synthetase/biotin 3-phosphate pseudaminic acid FadJ: fadJ 3-phosphate galactokinase: palmitoleoyl-CoA a ferricytochrome a [protein]-S- -glycerol amino acid AMP decenoyl-ACP decenoyl-ACP glucosamine-1- glucosaminyl- a guanine in DNA a CDP-1-acyl- no poly-A tail hydroxybutanoyl-[acp] ACP synthase GTP phosphopyruvate synthase: pseI 6-phosphate 34 deacetylase: nagA dehydrogenase: galK b operon repressor: 5 methyl-L-cysteine [DNA] isomerase: fabA isomerase: fabA GDP-mannose biosynthesis phosphate N- a queuosine in tRNA (3E,5Z)-tetradeca- diphospho- 2-arachidonoyl- II: fabF GTP hydratase: eno glucose-6- D-glucosamine F6P gap N,N'- N-acetyl-D- bifunctional 3- a 3-oxooctadecanoyl- MADE_RS17140 1-deoxy-D- acetyltransferase pseudaminate 3,5-dienoyl-CoA (S)-3-hydroxy-(5Z) α ditrans,octacis glycerol 3-hydroxyacyl- 6-phosphate -D-galactose α diacetylchitobiose glucosamine 3-hydroxyacyl- a [biotin carboxyl- xylulose-5- cyclohydrolase D-glucopyranose phosphate acyl-CoA -tetradecenoyl-CoA glyceraldehyde- UDP- -D-glucose -undecaprenol hydroxydecanoyl- ACP [acp] 7,8- 2-phospho-D-glycerate GlmU: glmU pseudaminic acid 1-phosphate ACP carrier protein]-N phosphate I FolE: folE 6-phosphate dehydrogenase: thioesterase: phosphoglucosamine 3-phosphate ACP dehydratase/ dehydratase dihydroneopterin glucose-6- N-acetyl-α-D- cytidylyltransferase: fatty acid dehydratase 6 -biotinyl-L-lysine synthase: dxs zwf MADE_RS05840 mutase: glmM dehydrogenase: trans-2- FabZ: fabZ 3'-triphosphate phosphate glucosamine pseF oxidation UDP-N-acetyl- undecaprenyldiphospho- di-trans,octa-cis a 2'- a peptide with a [ribosomal a protein an unstable FabZ: fabZ 6-phospho lipoprotein posttranslational modification MADE_RS11600 UDP-α-D-glucose a [protein]- a DNA methyl 4-nitrophenyl 4-nitrophenyl N-acetyl-L- decenoyl-ACP a (2E)-dodec- a (2E)-dec- [+ 4 isozymes] complex α-D-glucosamine α-D-glucosamine N-acetylmuramoyl-L- -undecaprenyl glycerophosphoglycerol deoxyribonucleoside an N-terminal canavaninosuccinate protein L3]- with incorrect a protein RecA filament- 1-deoxy-D-xylulose 6-carboxytetrahydropterin isomerase: pgi 1-phosphate CMP-pseudaminate D-glucono- L-cysteine phosphotriester [DNA] palmitate butanoate isomerase: fabA 2-enoyl-[acp] 2-enoyl-[acp] a (3R)-3- subunit alpha 1-phosphate γ phosphate 5'-triphosphate L-glutamine aspartate DNA complex 5-phosphate synthase: MADE_RS09780 F6P bifunctional UDP-N- 1,5-lactone a [prolipoprotein]- (3E,5Z)- alanyl- -D-glutamyl-meso Xaa-L-proline 50S ribosomal disulfide bondsbifunctional zinc-dependent DNA hydroxyoctadecanoyl- a [biotin carboxyl- 3-phospho-D-glycerate FadJ: fadJ 13-DPG 3-hydroxyacyl- bifunctional 3- acetylglucosamine L-cysteine tetradecadienoate bifunctional UDP-N- -2,6-diaminopimeloyl- protein L3 protein-disulfide metalloprotease: repair bifunctional 3- [acp] carrier-protein dimer]- 1-deoxy-D-xylulose- 6-carboxy-5,6,7,8- mannose-1-phosphate 6-phosphogluconolactonase: methylated-DNA-- glycerophosphodiester ACP hydroxydecanoyl- diphosphorylase/ prolipoprotein 3-oxo-(5Z)- acetylglucosamine D-alanyl-D-alanine undecaprenyl- DNA polymerase Xaa-Pro argininosuccinate arylesterase: arylesterase: N(5)-glutamine isomerase/ MADE_RS11365 protein hydroxydecanoyl- bifunctional 3- 6 tetrahydropterin phosphoglycerate pgl phosphoglycerate [protein]-cysteine S- phosphodiesterase: glpQ aspartoacylase: N -biotinyl-L-lysine 5-phosphate guanylyltransferase/ tetradecenoyl-CoA lyase: argH MADE_RS06960 MADE_RS06960 dehydratase ACP dehydratase/ ACP dehydratase/ kinase: glucosamine-1- glycogen biosynthesis I (from ADP-D-Glucose) diacylglyceryl diphosphorylase/ kinase: phosphate glucose III subunit chi: aminopeptidase: methyltransferase: oxidoreductase [+ 2 isozymes] RecO: hydroxydecanoyl- acetyl-CoA acetyl-CoA reductoisomerase: 7-carboxy-7- mannose-6- D-gluconate undecaprenyldiphospho- methyltransferase: glycerophosphodiester MADE_RS14805 FabZ: fabZ trans-2- trans-2- MADE_RS04290 phosphate N- transferase: lgt acetyl-CoA C- glucosamine-1- MADE_RS04290 phosphotransferase: MADE_RS15750 pepP a [ribosomalprmB DsbC: dsbC a peptide a stabilizedrecO ACP dehydratase/ carboxylase carboxylase MADE_RS04910 deazaguanine phosphate isomerase: 6-phosphate muramoylpentapeptide beta-N- MADE_RS18870 phosphodiesterase: a protein decenoyl-ACP decenoyl-ACP acetyltransferase a [prolipoprotein]- acyltransferase phosphate N- MADE_RS07905 [+ 10 isozymes] protein L3]- RecA filament- trans-2- carboxyltransferase biotin synthase MADE_RS07900 D-glucopyranose 6-phosphate 3-phospho- acetylglucosaminyltransferase: MADE_RS02600 with correct a (2E)-but-2-enoyl-[acp] isomerase: fabA GlmU: glmU NADP-dependent S-1,2-diacyl-sn- FadA: fadA acetyltransferase L-canavanine fumarate 4-nitrophenol palmitate butanoate 4-nitrophenol 5 isomerase: fabA decenoyl-ACP MEP 13-DPG D-glycerate murG a peptide with N -methyl- disulfide bonds DNA complex subunit beta: carboxylase QueE: queE mannose-1-phosphate CMP-3-deoxy-D- phosphogluconate glyceryl-L-cysteine a [protein]-S- a proteinogenic acetate a (3Z)-dodec- isomerase: fabA UDP-N-acetyl- alpha-D-glucose [+ 2 isozymes] GlmU: glmU α-D-glucopyranosyl- UMP [DNA] an N-terminal L-glutamine asp a (3Z)-dec- MADE_RS12025 subunit: accC 7-carboxy-7- guanylyltransferase/ dehydrogenase: gndA 2,3- methyl-L-cysteine amino acid 3-enoyl-[acp] 2-C-methyl-D- type I α-D-glucosamine manno-octulosonate phosphate-specific N-acetyl-α-D- diphosphoundecaprenol glycerol sn-glycerol [DNA] L-proline 3-enoyl-[acp] 3-hydroxyacyl- a [carboxyl-carrier signal (3Z)-dodec- diphosphoglycerate- lipid II (meso UDP erythritol 4-phosphate deazaguanine glyceraldehyde- mannose-6- biosynthesis phosphoglucomutase: D-ribulose glucosamine UDP-glucose 3-phosphate beta-ketoacyl- ACP protein dimer]-N 6 - peptidase 3-enoyl-CoA dependent diaminopimelate containing) beta- cytidylyltransferase: 7-cyano-7- 3-phosphate phosphate isomerase: D-ribulose MADE_RS07550 5-phosphate 1-phosphate UDP-glucose-- 4-epimerase ACP synthase dehydratase carboxybiotinyl-L-lysine II: lspA ∆3,∆2- phosphoglycerate ketoacyl- ispD deazaguanine dehydrogenase: MADE_RS17330 5-phosphate hexose-1-phosphate GalE: galE a butanoyl-[acp] II: fabF FabZ: fabZ D-arabinose [+ 2 isozymes] enoyl-CoA bifunctional UDP-N- mutase: gpmA ACP 4-(cytidine 5'- synthase gap D-mannopyranose ribulose- ribose-5- uridylyltransferase: UDP-glucose a [2-oxoglutarate- UDP-N-acetyl-α-D-muramoyl-L- sn-glycero-3- adenine 2030 a [protein]-L- a dipetide with an N- a mismatched α 5-phosphate α-D-glucopyranose an (S-diacyl-sn- isomerase: acetylglucosamine a sulfurated isobutanoate pimeloyl-CoA a peptide with a a (1->4)-α-D-glucan an isocitrate beta-ketoacyl- beta-ketoacyl- synthase a (2E)-octadec- QueC: queC 6-phosphate UDP- -D- phosphate 3- phosphate a lipoprotein 2-phospho- MADE_RS01105 4-epimerase SAM dehydrogenase alanyl-γ-D-glutamyl-meso-2,6- ala β terminal L-aspartate a protein a protein diphospho)-2-C- glyceraldehyde- isomerase: 1-phosphate glyceryl)-L-cysteinyl- fadB diphosphorylase/ [sulfur carrier] phosphoethanolamine leader sequence in 23S rRNA -isoaspartate dehydrogenase DNA base pair ACP synthase galactose epimerase: isomerase signal peptide D-glycerate α-D-glucopyranose E2 protein] N 6 - diaminopimeloyl-D-alanyl-D-alanine 23S rRNA 1,4-alpha-glucan- protein-L- DNA ACP synthase II: fabF 2-enoyl-[acp] methyl-D-erythritol phosphomannomutase/ MADE_RS04145 glucosamine-1- UDP-α-D-galactoseGalE: galE bifunctional HyaD/HybD family ATP- preQ 3-phosphate aldehydo-D- glucose-1-phosphate [apolipoprotein] ∆ 3 ∆ 2 branching protein: I: fabB phosphatidylserine and 0 biosynthesis rpe RpiA: rpiA -cis- -trans- 1-phosphate octanoyl-L-lysine (adenine(2030)-N(6) isoaspartate(D- mismatch I: fabB beta- 4-(cytidine 5'- phosphoglucomutase: signal peptide phosphate N- phosphopyruvate isocitrate hydrogenase dependent zinc phosphatidylethanolamine triose-phosphate dehydrogenase: α arabinose 5- adenylyltransferase: apolipoprotein N- enoyl-CoA acetate--CoA glycerophosphodiester )-methyltransferase MADE_RS15865 aspartate) O- repair beta-ketoacyl- a (5Z)-3-oxo- ketoacyl- diphospho) MADE_RS09565 UDP- -D-glucose peptidase hydratase: eno 8-amino-7- signal dipeptidase dehydrogenase maturation metalloprotease isomerase: MADE_RS11600 phosphate glgC acetyltransferase alpha-D-glucose penicillin-binding phosphodiesterase: biosynthesis I -2-C-methyl- D-xylulose D-ribose 5- acyltransferase: lnt SppA: sppA isomerase: lipoyl ligase: acs peptidase RlmJ: 1,4-alpha-glucan methyltransferase: PepE: pepE endopeptidase: protein ACP synthase tetradec-5-enoyl-[acp] ACP MADE_RS09240 phosphomannomutase/ UDP-glucose GlmU: glmU protein 2: mrdA MADE_RS02600 oxononanoate kinase/ FtsH: ftsH D-erythritol D-glyceraldehyde 5-phosphate phosphate an N-acyl-(S-diacyl- fadJ phosphoenol phosphate-specific synthase: MADE_RS10010 branching MADE_RS03240 MutS: mutS II: fabF synthase a CDP-diacylglycerol DHAP phosphoglucomutase: 4-epimerase a (1->4)-α-D-glucan ADP-α-D-glucose synthase: I: lepB an N 6 - a protein L-β- phosphatase: MADE_RS01630 a peptide a properly a stearoyl-[acp] kinase: ispE 3-phosphate sn-glyceryl)-L- a peptide UDP-N-acetyl- pyruvate phosphoglucomutase: lipA glycerophosphodiester protein GlgB: glgB I: fabB CDP-diacylglycerol--serine GalE: galE (2E)-dodec- MADE_RS06820 methyladenine 2030 isoaspartate aceK matched MADE_RS17335 glycogen cysteinyl-[lipoprotein] α-D-glucosamine MADE_RS07550 phosphodiesterase: glpQ a (1,6)-α-D-glucosyl- a phosphorylated a peptide a 3-oxohexanoyl-[acp] a (5Z)-3- O-phosphatidyltransferase: 2-phospho-4-(cytidine D-arabinofuranose transketolase: tkt 2-enoyl-CoA pyruvate UDP-N-acetylmuramoyl-L- isobutanoyl-CoA diphosphate α a proteinogenic indole-3-acetate α-D-mannose UDP-glucose UDP-N-acetylglucosamine a [2-oxoglutarate AMP in 23S rRNA (1,4)-α-glucan -methyl ester asp isocitrate DNA base pair oxododec- pssA 5'-diphospho)-2-C- 5-phosphate synthase kinase: pyk [+ 2 isozymes] 5'-deoxyadenosine an unsulfurated D-ala alanyl-γ-D-glutamyl-meso-2,6- amino acid a (3R,5Z)-3-hydroxy- biosynthesis 1-phosphate 4-epimerase fatty acid 1-carboxyvinyltransferase: met dehydrogenase (8S)-8-amino-7- a leader sequence a peptide dehydrogenase a 3-sn-phosphatidyl- methyl-D-erythritol GlgA: glgA [sulfur carrier] diaminopimeloyl-D-alanine 5-enoyl-[acp] IV (bacteria) fructose GalE: galE 3-deoxy-8- D-sedoheptulose D-glyceraldehyde oxidation D-glucopyranose E2 protein] N 6 sn-glycerol coenzyme A tetradec-5-enoyl-[acp] L-serine 2-C-methyl-D- mannose-1-phosphate murA pyruvate ethanolamine oxononanoate (indol-3-yl) bisphosphate UDP-α-D-galactose phosphooctulonate a (1->4)-α-D-glucan 7-phosphate 3-phosphate complex 6-phosphate -lipoyl-L-lysine 3-phosphate stearate phosphatidylserine erythritol 2,4- guanylyltransferase/ 5-oxo-L-proline metabolism UDP-N-acetyl-α- 3-hydroxyacyl- acetonitrile aldolase: synthase: kdsA subunit alpha cyclodiphosphate mannose-6- 1,4-alpha-glucan- D-glucosamine- a (3R)-3- ACP decarboxylase: psd MADE_RS04295 transaldolase: tal FadJ: fadJ a (3R,5Z)-3- long-chain- synthase: ispF phosphate isomerase: branching protein: a [protein] with a [protein] with enolpyruvate hydroxyhexanoyl-[acp] dehydratase an L-1- KDO-8P a peptidoglycan dimer with a [DNA]-3'- a 5'-phospho- a Chi-site containing a RecA DNA a [DNA]-3'- uridine 746 an [amino-group carrier a phosphorylated (3R,5S)-3- a [protein]-L- hydroxydodec- fatty-acid-- (indol-3-yl) an N-terminal an N-terminal (S)-3- + a (1->4)-α-D-glucan tributyrin FabZ: fabZ MADE_RS07900 MADE_RS15865 UDP-N- pentapeptide stems (meso- NAD double stranded recombination a type IV prepilin protein]-C-terminal-γ- isocitrate hydroxy-1- Ins(1,4,5)P phosphatidylethanolamine 2-C-methyl-D-erythritol- PRPP biosynthesis D-erythrose hydroxyl [DNA] ATP hydroxyl in 23S rRNA 3 methionine bifunctional 3- 5-enoyl-[acp] CoA ligase acetamide F6P L-glutamine L-glutamate hydroxydodecanoyl-CoA a tRNA precursor 1,4-alpha-glucan- bifunctional 3- 2,4-cyclodiphosphate mannose-1-phosphate 3-deoxy- 1,4-alpha-glucan acetylmuramate diaminopimelate containing) DNA with a blunt end and repair protein bifunctional tRNA (L-glutamyl)-L-glutamate dehydrogenase pyrroline-5- inosine/ peptide- hydroxydecanoyl- 3-hydroxyacyl- FadD: fadD β-D-fructose 1,6- 4-phosphate CTP branching protein: bifunctional amidase: guanylyltransferase/ manno- branching fatty acid dehydrogenase: pseudouridine(32) acetylglutamate carboxylatepyrroline-5- xanthosine methionine ACP dehydratase/ hydroxydecanoyl- ACP flavodoxin- bisphosphate D-ribose 5- exodeoxyribonuclease triacylglycerol isocitrate MADE_RS07840 octulosonate-8- protein GlgB: glgB oxidation murB DNA ligase: synthase/23S rRNA MADE_RS15865 (S)-S-oxide ACP dehydratase/ dehydratase stearoyl-CoA mannose-6- phosphate transketolase: tkt 1,6-anhydro-N- kinase: argB lipase: dehydrogenase carboxylate triphosphatase: trans-2- dependent class 1 fructose- ribose-phosphate complex MADE_RS03870 exodeoxyribonuclease III: xthA prepilin peptidase: pseudouridine(746) reductase trans-2- amidase: phosphate isomerase: phosphatase UDP-N-acetyl- acetylmuramyl-L- CCA-adding 1,4-alpha-glucan an [amino-group carrier kinase/ reductase: yjjX decenoyl-ACP FabZ: fabZ (E)-4-hydroxy- bisphosphatase: pyrophosphokinase: a glycogen a [protein] with subunit alpha α V: recD recB recC exodeoxyribonuclease MADE_RS14785 MADE_RS18185 decenoyl-ACP long-chain fatty MADE_RS19100 MADE_RS17330 KdsC: kdsC D-glyceraldehyde γ-L-glutamyl -D-muramate alanine amidase enzyme: synthase RluA: rluA branching MADE_RS15095 MsrA: msrA isomerase: fabA 3-methylbut- an N-terminal 5- 746 protein]-C-terminal- phosphatase: Ins(1,4)P a protein-L- bifunctional 3- acid activation MADE_RS01035 MADE_RS07430 3-phosphate glutathione FadJ: fadJ MADE_RS04585 I: sbcB a pseudouridine protein GlgB: glgB Hyp 2 isomerase: fabA 2-enyl- (indol-3-yl)acetate α-Kdo oxo-L-proline 5-phosphate UDP-N- AmpD: ampD γ-(5-phospho-L- aceK methionine- 3-hydroxyacyl- hydroxydecanoyl- GDP-α-D-mannose PRPP in 23S rRNA F6P acetylmuramate:L- [DNA] NMN a double stranded DNA a GlgE-glycogen glutamyl)-L-glutamate 1,2-dibutyrin an isocitrate (S)-S-oxide a (2E,5Z)-tetradeca- ACP dehydratase/ a long-chain fatty acid diphosphate 3-oxododecanoyl-CoA AMP a 2'- a cleaved type butanoate ACP gondoate biosynthesis 3-deoxy-manno- γ with a RecA protein a tRNA a [DNA]-3'- a peptide dehydrogenase 2,5-dienoyl-[acp] synthase: ispG alanyl-gamma-D- a peptidoglycan dimer with L-alanyl- -D-glutamyl- IV prepilin dehydratase trans-2- long-chain- glucose-6- acetyl-CoA C- loaded 3' overhang containing a deoxyribonucleoside (anaerobic) (E)-4-hydroxy-3- octulosonate glutamyl- meso- pentapeptide stem (meso- meso-2,6-diaminopimeloyl- hydroxyl FabZ: fabZ decenoyl-ACP fatty-acid-- phosphate 5'-monophosphate cytidylyltransferase: acyltransferase: diaminopimelate diaminopimelate containing) D-alanyl-D-alanine 3' CCA end isomerase: fabA CoA ligase methylbut-2-en- NADH repair (prokaryotes) isomerase: pgi kdsB 5-oxo-L-proline MADE_RS08585 ligase: mpl a (2E)-hex-2-enoyl-[acp] an oleoyl-[acp] FadD: fadD 1-yl diphosphate a (2E,5Z)-dodeca- beta-ketoacyl- a long-chain myo-inositol D-glucopyranose [+ 2 isozymes] a short a short a (5Z)-tetradec- CMP-Kdo NADH 5-oxoprolinase: UDP-N-acetyl- UDP-N-acetyl-α-D-muramoyl- N-acetyl-β-D-glucosaminyl-(1 (1S,2R)-1- 4-methyl-5-(2- hydrogen succinate RNase II 3,5-dienoyl-[acp] ACP synthase fatty acyl-CoA biosynthesis 6-phosphate di-trans,octa-cis- a proteinogenic leukotriene-C4 dihydrolipoamide an adenine in DNA a (1->4)-α-D-glucan A(H2) RNA roseoflavin chain RS12165 chain 5-enoyl-[acp] 4-hydroxy- pxpB decanoyl-CoA α-D-muramoyl- L-alanyl-γ-D-glutamyl-L- -> 4)-N-acetyl-β-D-muramate ser C-(indol-3- phosphooxyethyl) ethylphosphate peroxide semialdehyde degradation II: fabF undecaprenyl phosphate amino acid HMP-PP 1,4-alpha-glucan- fatty acid fatty acid 3-methylbut- D-glucopyranose MADE_RS11180 L-alanyl-γ-D- lysyl-D-alanyl-D-alanine dihydrolipoyllysine- yl)glycerol thiazole Dam family site- acid phosphatase: NAD-dependent substrate mRNA bifunctional beta-ketoacyl- beta-ketoacyl- acyl-CoA branching protein: riboflavin 2-enyl 6-phosphate glutamyl-meso-2,6- residue acetyltransferase: beta-hexosaminidase: 3-phosphate specific DNA- MADE_RS18515 succinate- ribonuclease ACP synthase ACP synthase 4-hydroxy- dehydrogenase: MADE_RS10005 (adenine-N6)- MADE_RS15865 catalase/ ribonuclease semialdehyde kinase/FAD a hexanoyl-[acp] diphosphate glu diaminopimelate phospho-N- gamma- MADE_RS02830 thiamine alkaline R: rnr II: fabF a (5Z)-dodec- I: fabB MADE_RS13750 tryptophan peroxidase PH: rph synthetase: Peptide RS04735 Peptide 3-methylbut- reductase: acetylmuramoyl- glutamyltransferase: ggt pyruvate phosphate methyltransferase: 1,4-alpha-glucan phosphatase: dehydrogenase: beta-ketoacyl- 5-enoyl-[acp] an (11Z)-3-oxo- (R)-NADHX beta-N- synthase: HPI: katG a nucleoside 5'- 2-enyl ispH Ins(3)P [+ 2 isozymes] pentapeptide- dehydrogenase complex synthase: thiE MADE_RS02410 branching MADE_RS19270 ribF beta-ketoacyl- icos-11-enoyl-[acp] bifunctional [+ 2 isozymes] acetylhexosaminidase: 6 MADE_RS13365 ACP synthase diphosphate transferase: mraY trpA trpB an N -methyladenine protein GlgB: glgB monophosphate roseoflavin ACP synthase ADP-dependent dihydrolipoyllysine-residue nagZ ethanol succinate I: fabB reductase: inositol-1- (2E)-dec-2-enoyl-CoA in DNA a nucleoside 5'-phosphate I: fabB NAD(P)H-hydrate acetyltransferase: aceF starch A H O RNA Carboxylate Degradation an α-(γ-L-glutamyl) D-glyceraldehyde 2 chloride RS15640 chloride a (7Z)-3-oxo- ispH IPP monophosphatase: periplasmic disulfide bond formation leukotriene-D4 S-acetyldihydrolipoamide thiamine phosphate diphosphate beta-ketoacyl- dehydratase/ fatty acid undecaprenyl-diphospho-N- UMP -L-amino acid 3-phosphate trp hexadec-7-enoyl-[acp] suhB γ GlcNAc N-acetyl-D-muramate ACP synthase phosphatidylglycerol a (3R,11Z)-3-hydroxy- NAD(P)H-hydrate a [DsbB protein] a [DsbA protein] two reduced oxidation acetylmuramoyl-L-alanyl- -D- an electron- 2-methylcitrate cycle II II: fabF biosynthesis I (plastidic) icos-11-enoyl-[acp] myo-inositol epimerase: with reduced L- carrying a cysteine residues complex pyruvate decarboxylation to acetyl CoA I superpathway of acetate glutamyl-L-lysyl- D-alanyl-D-alanine MADE_RS18265 transfer quinone in a protein subunit alpha utilization and formation 2+ 2+ (S)-NADHX cysteine residues disulfide bond Ca RS04150 Ca 3-hydroxyacyl- propanoate pyruvate a 3-oxooctanoyl-[acp] DHAP FadJ: fadJ a [pyruvate dehydrogenase α 32 2251 a protein-L- ACP dehydratase UDP-N-acetyl- -D- an L-arginyl- a [protein]- a uridine guanosine a double NAD(P)H- E2 protein] N 6 -lipoyl-L-lysine dehydrogenase acetate di-trans,octa-cis- γ a proteinogenic glutathione 2-oxoglutarate FAD (S)-2- D-glucopyranose a (3R,7Z)-3-hydroxy- bifunctional (S)-3- acetate--CoA muramoyl-L-alanyl- -D- a protein Arg D-ala L-threonine glu stranded DNA met mutated tRNA methionine- RS01770 FabZ: fabZ DMAPP long-chain- pyruvate(acetyl-transferring) undecaprenyl phosphate amino acid [tRNA ] aminobutanoate in tRNA in 23S rRNA GTP RS01775 hexadec-7-enoyl-[acp] dependent ADP-dependent hydroxydecanoyl-CoA pyruvate ligase: acs glutamyl-L-lysyl-D-alanine bifunctional tRNA 23S rRNA glucose 1- DNA (R)-S-oxide bifunctional 3- fatty-acid- , homodimeric acetate kinase: amino-acid N- peptide- 2+ Zn 2+ glycerol-3- NAD(P)H-hydrate dehydrogenase pseudouridine(32) (guanosine(2251) adenylate/guanylate dehydrogenase: topoisomerase Zn RS17940 3-hydroxyacyl- fatty acid -CoA type: aceE FAD:protein FMN ribonuclease methionine 2+ 2+ phosphate hydroxydecanoyl- MADE_RS07260 synthase/23S rRNA -2'-O)- cyclase domain- MADE_RS08570 (ATP- acetyltransferase: Cu Cu ACP dehydratase/ oxidation ligase complex phospho-N- gamma- D-amino acid glutamate-- R: rnr (R)-S-oxide a (3R)-3- dehydrogenase: ACP dehydratase/ dihydrolipoyllysine- arginyltransferase: transferase: pseudouridine(746) containing protein: argA dehydratase NAD(P)H-hydrate complex dihydrolipoyllysine- pyruvate acetylmuramoyl- glutamyltransferase: ggt aminotransferase: cysteine ligase: methyltransferase glucose 1- hydrolyzing) trans-2- FadD: residue acetyl phosphate acetyl-CoA MADE_RS09070 MADE_RS16895 a nucleoside 5'- reductase hydroxyoctanoyl-[acp] gpsA epimerase: subunit alpha residue dehydrogenase MADE_RS11165 MADE_RS06035 synthase RluA: rluA RlmB: rlmB MADE_RS09020 dehydrogenase: subunit B: gyrB N-acetyl-L- FabZ: fabZ fadD pentapeptide- [+ 2 isozymes] 32 MsrB: msrB sn-glycerol decenoyl-ACP acetyltransferase: a pseudouridine 2-O- cyclic-GMP monophosphate MADE_RS18265 FadJ: fadJ acetyltransferase: complex 2251 MADE_RS11070 [+ 2 isozymes] methionine a [protein]-L- a purine RS07810 a purine bifunctional 3- bifunctional 3- 3-phosphate transferase: mraY methylguanosine isomerase: fabA propanoyl-CoA aceF MADE_RS10005 dihydrolipoyllysine- a [protein]-FMN- in tRNA D-glucono- a negatively methionine hydroxydecanoyl- hydroxydecanoyl- α γ an N-terminal γ-L-glutamyl-(S)- in 23S rRNA glycerol-3- NADH 3-oxodecanoyl-CoA residue an -( -L-glutamyl) Arg L-threonine 1,5-lactone supercoiled DNA ACP dehydratase/ a (2E,11Z)-icosa- pyruvate phosphate undecaprenyl-diphospho-N L-cysteinylglycine a tRNA arginyl-[protein] D-glt pyruvate AMP ACP dehydratase/ phosphate 1-O- dihydrolipoyl acetyltransferase: UMP -L-amino acid 2-aminobutanoate trans-2- 2,11-dienoyl-[acp] DsbA family 2-methylcitrate dehydrogenase a [pyruvate dehydrogenase acetyltransferase: pta -acetylmuramoyl-L-alanyl-γ- trans-2- acyltransferase fatty acid dehydrogenase:a [pyruvate lpdA dehydrogenase E2 aceF decenoyl-ACP oxidoreductase: synthase: prpC complex E2 protein] N 6 -S- D-glutamyl-L-lysyl- D-alanine decenoyl-ACP PlsY: plsY oxidation protein] N 6 -dihydrolipoyl-L-lysine isomerase: fabA MADE_RS11290 dihydrolipoyllysine-acetyldihydrolipoyl-L-lysine isomerase: fabA a 1-acyl-sn a [DsbB protein] a [DsbA protein] complex (2S,3S)-2- an electron- an intra- methylcitrate residue 3-hydroxyacyl- -glycerol 3- acyl-CoA hydrolysis carrying a with reduced L- subunit alpha an N-terminal an N-formyl-L- 2-dehydro- an N-terminal L- a cytidine a (2E,7Z)-hexadeca- transfer quinol protein disulfide acetyltransferase: cob(II)inamide glutathione an L-arginyl- carbamoyl citrate D-glucopyranose SAICAR ACP disulfide bond cysteine residues FadB: fadB Fe/S-dependent hypoglycin A 3-sulfino-L- methionylaminoacyl- L-ornithine 3-deoxy-D- alanyl-[S18 protein 32 glu Ap4A phosphate a gondoyl-[acp] Arg in tRNA dADP 2,7-dienoyl-[acp] aceF ATP [tRNA ] phosphate glucose 1- dehydratase 1-acyl-sn-glycerol- a 2,3,4-saturated [+ 4 isozymes] 2-methylisocitrate alanyl-[protein] tRNA gluconate putative of 30S ribosome]ribosomal protein bifunctional tRNA (cytosine(32) symmetrical FabZ: fabZ pyruvate fermentation to acetate IV aconitate hydratase /uridine(32)-2'-O)- dehydrogenase: amino-acid N- ribonucleoside- 3-phosphate fatty acyl CoAacyl-CoA dehydratase ketodeoxygluconokinase: S18-alanine N- bis(5'-nucleosyl)- MADE_RS11070 acetyltransferase: acyltransferase: octanoyl-CoA AcnD: acnD gamma- peptide ornithine MADE_RS16145 acetyltransferase: 2/2-methylisocitrate methyltransferase adenylosuccinate tetraphosphatase: diphosphate thioesterase: 6 37 cob(I)yrinic acid arginyltransferase: a (2E)-oct-2-enoyl-[acp] N -L-threonylcarbamoyladenosine dehydratase: acnB TrmJ: trmJ glucose 1- lyase: purB argA reductase: MADE_RS11040 MADE_RS05840 2-methyl-trans pyruvate glutamyltransferase: ggt deformylase: carbamoyltransferase: putative an N-terminal N-acetyl-rimI a 2'-O- MADE_RS03895 a (7Z)-hexadec- -modified tRNA biosynthesis acyl-CoA acetyl-CoA a,c-diamide MADE_RS09070 MADE_RS00100 MADE_RS02515 [+ 2 isozymes] 32 dehydrogenase: N-acetyl-L- nrdA nrdB 1-acylglycerol- [+ 4 isozymes] dehydrogenase: -aconitate pyruvate fermentation adenosyltransferase: [+ 2 isozymes] ketodeoxygluconokinase: L-alanyl-[S18 protein methylcytidine ADP 7-enoyl-[acp] a 2,3,4-saturated D-threo-isocitrate MADE_RS08570 glutamate ADP 3-phosphate O- 2-oxoglutarate decarboxylation to succinyl-CoA Respiration MADE_RS13750 2-methylaconitate to acetate II MADE_RS08105 MADE_RS16235 of 30S ribosome] in tRNA beta-ketoacyl- fatty acid thr an N-terminal L- D-glucono- AICAR fumarate acyltransferase: cis-trans KDGP [+ 2 isozymes] Arg arginiyl-3-sulfino- a L-methionylaminoacyl- 1,5-lactone ACP synthase MADE_RS15705 a [2-oxoglutarate threonylcarbamoyl- isomerase pyruvate hypoglycin B L-cysteinylglycine a tRNA formate L-citrulline adenosylcobinamide L-alanyl-[protein] tRNA an octanoyl-[acp] II: fabF a 1,2-diacyl- dehydrogenase AMP synthase: (2E)-oct-2-enoyl-CoA PrpF: prpF pyruvate acetyl-CoA formate triphosphate sn-glycerol 6 MADE_RS07050 beta-ketoacyl- E2 protein] N (L-threonylcarbamoyl) cis-2- dehydrogenase complex beta-ketoacyl- 3-phosphate fatty acid ACP synthase -lipoyl-L-lysine adenylate methylaconitate dihydrolipoyllysine- phosphate ACP synthase I: fabB phosphatidate 2-oxoglutarate oxidation residue acetyltransferase: pta tRNA (adenosine(37)-N6)- bifunctional an N-terminal RNase III mRNA all-trans- a guanosine 18 a [release factor]- I: fabB cytidylyltransferase: dehydrogenase 2-oxoglutarate complex acetyltransferase: aceF cob(II)alamin coenzyme A an apo [peptidyl- an L-arginyl- NADP + FMNH a phenyl acetate phenyl acetate L(or D)-O- histidinol 3-sulfo-L- processing hexaprenyl 2 L-homoserine a protein a (9Z)-3-oxo- threonylcarbamoyltransferase aconitate ATP Arg 4-aminobenzoate in tRNA L-glutamine beta-ketoacyl- MADE_RS04905 E1 component: dehydrogenase subunit alpha acetyl-CoA acetyl phosphate carrier protein] [tRNA ] substrate phosphoserine octadec-9-enoyl-[acp] fatty acid elongation -- saturated complex dimerization hydratase 2/2- alanyl-[protein] diphosphate tRNA peptide chain histidinol HslU--HslV ACP synthase a CDP- MADE_RS09600 E1 component: FadJ: fadJ homoserine O- phosphoserine subunit type 1 TsaB: tsaB methylisocitrate (guanosine(18)-2'-O) release factor dehydrogenase: peptidase II: fabF diacylglycerol dihydrolipoyl MADE_RS09600 (S)-3- phosphate acetate kinase: flavin reductase: succinyltransferase: arylesterase: phosphatase [+ 2 isozymes] dehydratase: acnB holo-ACP 4-hydroxybenzoate -methyltransferase N(5)-glutamine arylesterase: hisD ATPase: an acetoacetyl-[acp] hydroxyoctanoyl-CoA acetyltransferase: pta cob(I)yrinic acid arginyltransferase: ribonuclease MADE_RS19090 metA SerB: serB CDP-diacylglycerol-- dehydrogenase: an N 6 -L- MADE_RS07260 synthase: octaprenyltransferase: TrmH: trmH methyltransferase: MADE_RS06960 MADE_RS06960 a 3-oxodecanoyl-[acp] a [2-oxoglutarate a [2-oxoglutarate [+ 2 isozymes] a,c-diamide MADE_RS09070 III: rnc a 2'-O- hslU hslV glycerol-3-phosphate 3- lpdA 37 fatty acid MADE_RS03960 [+ 2 isozymes] prmC O-succinyl-L- his dehydrogenase dehydrogenase threonylcarbamoyladenine ubiA methylguanosine 18 serine a (3R,9Z)-3-hydroxy- (2R,3S)-2- acetyl phosphate acetate adenosyltransferase: a [release factor]-N 5 a peptide phosphatidyltransferase: 6 6 in tRNA oxidation homoserine octadec-9-enoyl-[acp] E2 protein] N E2 protein] N -S- methylisocitrate MADE_RS08105 in tRNA pgsA complex an N-terminal L- RNase III -methyl-L-glutamine acetate a phenol acetate phenol -dihydrolipoyl- succinyldihydrolipoyl- acetate kinase: 3',5'-ADP a holo [peptidyl- 3-all trans- FMN NADPH H + 3-hydroxyacyl- 1-(3-sn- subunit alpha a tRNA Arg arginiyl-3-sulfo- an mRNA fragment processing L-lysine L-lysine methylisocitrate adenosylcobalamin carrier protein] hexaprenyl-4- ACP phosphatidyl) a 3-oxoacyl-[acp] FadJ: fadJ MADE_RS07260 L-alanyl-[protein] product mRNA a (3R)-3- lyase: prpB triphosphate aminobenzoate dehydratase -sn-glycerol N-end rule pathway I (prokaryotic) hydroxydecanoyl-[acp] FabZ: fabZ 3-phosphate 3-oxooctanoyl-CoA acetate leucyl/ bifunctional 3- bifunctional 3- phosphatidylglycerophosphatase 2-oxoglutarate pyruvate succinate acetyl-CoA C- an apo-[LYS2 L- RNase E mRNA 2498 an [RNA]-3'- 32 phenylalanyl- an (S)-2- a cytidine a uridine a ribonucleoside an oxidized hydroxydecanoyl- hydroxydecanoyl- A: MADE_RS12705 dehydrogenase acyltransferase: a 5-L-glutamyl- coenzyme A coenzyme A [EntB aryl- FMN NADH H + α-amylose a DNA segment beta-ketoacyl- tRNA--protein an amino acid 2-aminoadipyl- processing halocarboxylate in 23S rRNA ribonucleoside- in tRNA nitroaromatic a protein ACP dehydratase/ ACP dehydratase/ an L-1- E1 component: MADE_RS08585 [peptide] carrier protein] diphosphate 1,4-alpha-glucan ACP synthase transferase: carrier-protein] substrate 23S rRNA 2',3'- tRNA (cytosine(32) ribonucleoside- compound recombinase trans-2- trans-2- phosphatidyl- MADE_RS09600 a [protein] NAD(P)H II: fabF aat [+ 2 isozymes] (cytidine(2498)-2'-O) cyclophosphate /uridine(32)-2'-O)- diphosphate branching decenoyl-ACP sn-glycerol an N-terminal HAD family RNA 2',3'-cyclic nitroreductase: RecA: recA endopeptidase decenoyl-ACP 2-oxoglutarate N-terminal L- C1 Compound Utilization and Assimilation holo-ACP holo-ACP flavin reductase: -methyltransferase methyltransferase protein GlgB: glgB beta-ketoacyl- arginyl-[protein] gamma- ribonuclease phosphodiesterase: reductase: [+ 2 isozymes] La: lon isomerase: fabA isomerase: fabA dehydrogenase leucyl-L-arginine hexanoyl-CoA Amine and Polyamine Degradation synthase: synthase: hydrolase: MADE_RS19090 RlmM: rlmM TrmJ: trmJ 1,4-alpha-glucan- MADE_RS09110 a DNA segment ACP synthase glutamyltransferase: ggt E: rne a 2-O- thpR a 2'-O- a 2'- nrdA nrdB a reduced 3-hydroxyacyl- a 2,3,4-saturated a (3R)-3-hydroxyacyl- complex MADE_RS03960 MADE_RS03960 MADE_RS08610 [+ 2 isozymes] an [RNA]-3'- branching protein: in reverse a (2E,9Z)-octadeca- I: fabB 3-hydroxyacyl- acyl-CoA formaldehyde oxidation [+ 2 isozymes] methylcytidine 2498 methyluridine 32 deoxyribonucleoside nitroaromatic a peptide ACP [+ 2 isozymes] ribunucleoside- 2,9-dienoyl-[acp] fatty acyl-[acp] [acyl-carrier protein] dihydrolipoyllysine- leucyl/ formaldehyde oxidation allantoin degradation in 23S rRNA MADE_RS15865 compound orientation ACP dehydratase dehydrogenase: VII (THF pathway) choline degradation I 2'-phosphate in tRNA 5'-diphosphate dehydratase residue phenylalanyl- II (glutathione-dependent) to ureidoglycolate II allantoin degradation a holo-[LYS2 L- RNase E FabZ: fabZ MADE_RS13750 an α-(5-L- a holo-[EntB aryl- FMNH NAD + amylopectin to ureidoglycolate 3',5'-ADP 2-aminoadipyl- 3',5'-ADP an mRNA fragment 2 FabZ: fabZ succinyltransferase: tRNA--protein formaldehyde (ammonia producing) processing a (2R)-2- [+ 2 isozymes] glutamyl)- a peptide carrier protein] a halide anion bifunctional 3- ATP odhB transferase: formaldehyde choline I (urea producing) carrier-protein] product mRNA hydroxy fatty acid a (2E)-dec-2-enoyl-[acp] hydroxydecanoyl- biosynthesis a [protein] (S)-(+)-allantoin amino acid an N-terminal aat (2E)-hexenoyl-CoA choline (S)-(+)-allantoin ACP dehydratase/ N-terminal L- allantoinase an oleoyl-[acp] L-lysyl-[protein] a 5,10- dehydrogenase: allantoinase trans-2- ADP leucyl-L-lysine fatty acid S-(hydroxymethyl) PuuE: puuE 1402 1498 α-Kdo8N- RNase G methylenetetrahydrofolate MADE_RS12240 PuuE: puuE hydrogen a cytidine a uracil pyridoxamine decenoyl-ACP oxidation hydrogen cyanide a sulfurated coenzyme A [EntF L-seryl- a reduced a peptide with a sulfite GSSH a holo [BryU acyl- [DNA] F0F1 ATP 2-oxoisovalerate decarboxylation glutathione allantoate choline meso-diaminopimelate UDP-N-acetyl-α-D-muramoyl- peroxide in 16S rRNA in 16S rRNA (2->6)-lipid IV degradation repressor LexA bifunctional allantoate urea degradation II [sulfur carrier] carrier protein] thioredoxin A 5'-phosphate isomerase: fabA synthase: atpC complex penultimate glycine carrier protein] 3-deoxy-D-manno- DNA substrate mRNA to isobutanoyl-CoA methylenetetrahydrofolate S-(hydroxymethyl) dehydrogenase: L-alanyl-D-glutamate 16S rRNA 16S rRNA ribonuclease a decanoyl-[acyl- atpD atpG subunit alpha allantoate ACP S- octulosonic polymerase pyridoxamine a 2,3,4-saturated a trans-2-enoyl- an [apo BCAA dehydrogenase/ glutathione betA (cytidine(1402)-2'-O) (uracil(1498)-N(3))- G: rng repressor carrier protein] FadJ: fadJ amidohydrolase: urea thiosulfate thiosulfate malonyltransferase: acid kinase: 5'-phosphate fatty acyl-[acp] [acyl-carrier protein] atpA atpH dehydrogenase dehydrogenase/ betaine aldehyde holo-ACP peroxiredoxin: -methyltransferase: methyltransferase: III subunit LexA: lexA palmitoleate methenyltetrahydrofolate MADE_RS07820 UDP-N-acetylmuramoyl- carboxypeptidase: sulfurtransferase fabD ribonuclease oxidase: pdxH atpF atpE atpB 6 urease: ureC sulfurtransferase synthase: MADE_RS00480 rsmI MADE_RS15055 MADE_RS00295 epsilon: dnaQ beta-ketoacyl- E2 protein] N alpha-ketoacid (S)-3- cyclohydrolase FolD: folD class III alcohol L-alanyl-D-glutamate-- a 2'-O- a malonyl- an N 3 - 4-O-phospho- biosynthesis I (from MADE_RS19870 betaine-aldehyde MADE_RS14140 GlpE: glpE MADE_RS03960 MADE_RS11985 GlpE: glpE E: rne cleaved ACP synthase -lipoyl-L-lysine dehydrogenase hydroxyhexanoyl-CoA dehydrogenase: (S)-ureidoglycine (S)-ureidoglycolate [+ 2 isozymes] 1402 1498 [+ 3 isozymes] PLP (5Z)-dodec-5-enoate) Cofactor, Carrier, and Vitamin Biosynthesis a 5,10- 2, 6-diaminopimelate methylcytidine [BryU acyl- methyluracil α-Kdo8N- a 2'- an mRNA fragment MADE_RS15225 dehydrogenase: MADE_RS14145 repressor LexA I: fabB ATP subunit beta: fatty acid ligase: MADE_RS14935 in 16S rRNA carrier protein] in 16S rRNA (2->6)-lipid IV deoxyribonucleoside dihydrolipoyl methenyltetrahydrofolate betB ammonium a holo-[EntF A a (5Z)-dodec- MADE_RS10000 oxidation an unsulfurated beta-ketoacyl- ubiquinol-8 biosynthesis dehydrogenase: thiocyanate 3',5'-ADP an oxidized H O a peptide with a glutathione thiosulfate 5'-monophosphate 5-enoyl-[acp] [2Fe-2S] iron-sulfur S-adenosyl-L- bifunctional S-formylglutathione L-seryl-carrier 2 ACP synthase beta-ketoacyl- superpathway of tetrahydrofolate biosynthesis acyl carrier NADP superpathway of heme b di-trans,poly-cis glutathione- complex glycine betaine UDP-N-acetyl-α-D-muramoyl-L-alanyl- [sulfur carrier] thioredoxin an amino acid (early decarboxylation) cluster biosynthesis methionine salvage II lpdA methylenetetrahydrofolate protein] C-terminal glycine II: fabF ACP synthase protein activation biosynthesis biosynthesis from glutamate -undecaprenyl glutaredoxin subunit alpha γ-D-glutamyl-meso-2,6-diaminopimelate all-trans- an [apo BCAA dehydrogenase/ S-formylglutathione (S)-ureidoglycolate II: fabF phosphate biosynthesis redox reactions an [apo BCAA dehydrogenase FadJ: fadJ 4-hydroxybenzoate octaprenyl an apo acyl- NAD + dehydrogenase methenyltetrahydrofolate hydrolase: fghA a 3-oxododecanoyl-[acp] beta-ketoacyl- L-cysteine desulfurase GTP glu SAH (2E,6E)-farnesyl glutathione E2 protein] N 6 -S-[2- diphosphate IPP 6 UDP-N-acetyl- decaprenyl-diphospho-N- 1402 (3R,6R)-1,3,4,6- D-myo-inositol a [lipoyl-carrier carrier protein NAD(+) diphosphate E2 protein] N 3-oxohexanoyl-CoA cyclohydrolase FolD: folD a cytidine ACP synthase holo-ACP methylpropanoyl]dihydrolipoyl- coenzyme A an apo-[aryl- hydrogen selenide coenzyme A H O a 9S rRNA a holo [BryP acyl- 6 an oligopeptide acetamide an unfolded adenosylhomocysteinase: 10 formate α-D-glucosamine acetylmuramoyl-pentapeptide diphosphate 2 tetrachlorocyclohexa- (1,3,4,5)- protein]-N -[(R) cysteine kinase: -dihydrolipoyl- an N - O-acetyl-L-serine VibB in 16S rRNA I: fabB 4-hydroxybenzoate GTP synthase: MADE_RS16020 L-lysine carrier protein] carrier protein] protein a (7Z)-3-oxotetradec- nadK L-lysine acetyl-CoA C- formyltetrahydrofolate 16S rRNA 1,4-diene tetrakisphosphateinosine/ -dihydrolipoyl]- amidase: octaprenyltransferase: desulfurase: cyclohydrolase MADE_RS03960 an L-glutamyl- di-trans,poly-cis- a reduced ACP S- haloalkane oligopeptidase 7-enoyl-[acp] a holo acyl- NADP + L-homocysteine acyltransferase: undecaprenyldiphospho- (cytosine(1402)-N(4) xanthosine L-lysine MADE_RS07840 chaperonin MADE_RS13210 I FolE: folE [tRNA Glu ] decaprenylcistransferase: formyltetrahydrofolate malonyltransferase: dehalogenase: dihydrolipoyl A: prlC ubiA carrier protein glutaredoxin MADE_RS08585 muramoylpentapeptide beta-N- holo-ACP cysteine holo-ACP inorganic ribonuclease )-methyltransferase triphosphatase: amidase: a (3R)-3- [+ 2 isozymes] 7,8- uppS deformylase: purU MADE_RS08575 dehydrogenase: GroEL: groL methionine synthase: [+ 2 isozymes] acetylglucosaminyltransferase: synthase: synthase synthase: diphosphatase: E: rne RsmH: rsmH fabD MADE_RS19100 hydroxydodecanoyl-[acp] dihydroneopterin glutamyl-tRNA glutathione- dihydrolipoyllysine- an N 4 - a malonyl- (1S,4R)-2,4,5- D-myo-inositolyjjX lpdA 4-hydroxy-3- an S-sulfanyl-[L- MADE_RS11395 murG MADE_RS03960 A: cysK MADE_RS03960 ppa a [lipoyl-carrier a peptide 3'-triphosphate reductase: di-trans,octa-cis dependent residue (2- formate methylcytidine 1402 [BryP acyl- trichloro-2,5- (1,3,4)- acetate a protein bifunctional 3- octaprenylbenzoate cysteine desulfurase] butanoyl-CoA protein]-N 6 -[(R a (3R,7Z)-3- dihydroneopterin MADE_RS07450 methionine synthase: metH -undecaprenyl disulfide-bond methylpropanoyl) in 16S rRNA carrier protein] cyclohexadiene-1-diol trisphosphate hydroxydecanoyl- )-lipoyl]-L-lysine hydroxytetradec- 4-hydroxy-3- triphosphate (S)-4-amino-5- diphosphate oxidoreductase: transferase: acyl-CoA decaprenyl-pyrophosphoryl- a holo-[aryl- acetate a holo-[VibB aryl- a 5S rRNA an rRNA fragment ACP dehydratase/ met UDP 3',5'-ADP L-selenocysteine 3',5'-ADP phosphate H + 7-enoyl-[acp] polyprenylbenzoate diphosphatase: oxopentanoate undecaprenyl- yghU MADE_RS10000 dehydrogenase: (N-acetylglucosamine)-N- carrier protein] carrier protein] trans-2- decarboxylase: ubiD 3-hydroxyacyl- nudB diphosphate glutaredoxin MADE_RS13750 acetylmuramyl-(pentapeptide) decenoyl-ACP an S-sulfanyl-[cysteine glutamate-1- methionine ACP 7,8- phosphatase: 3: grxC isomerase: fabA 2-octaprenylphenol desulfurase]-[disordered- semialdehyde adenosyltransferase: [+ 2 isozymes] dehydratase dihydroneopterin MADE_RS03735 a protein with form scaffold 2,1- MADE_RS04275 a [glycine-cleavage all-trans- all-trans- 1618 527 a 5,6- FabZ: fabZ di-trans,octa-cis lysine within adenine a guanine an organic 3-hydroxyacyl- 3'-phosphate reduced L- crotonyl-CoA chitin 20 3-aminopropanal sn-glycerol riboflavin protein] complex aminomutase: a sulfurated [sulfur carrier] SAM complex H protein] an octanoyl-[acp] decaprenyl hexaprenyl dihydrouracil a protein ACP -undecaprenyl cysteine residues gcv protein H 4-hydroxybenzoate 4-hydroxybenzoate dAMP in 23S rRNA in 16S rRNA 3-phosphate hydroperoxide bifunctional 3- [cysteine desulfurase]-S- flavin biosynthesis I (bacteria and plants) hemL SAM N 6 -octanoyl-L-lysine diphosphate diphosphate 23S rRNA 16S rRNA in tRNA thiol NAD(P) dehydratase phosphate fatty acid tRNA betaine-aldehyde ATP-dependent glycerol-3- hydroxydecanoyl- 3-(all-trans sulfanylcysteine:[acceptor 5'-deoxynucleotidase: (adenine(1618)-N(6) (guanine(527)-N(7) peroxidase: H-flavin FabZ: fabZ oxidation beta-hexosaminidase: dihydrouridine(20/ dehydrogenase: Clp endopeptidase phosphate ACP dehydratase/ -octaprenyl) protein]-cysteine 5-aminolevulinate lipoyl(octanoyl) yfbR )-methyltransferase tpx reductase: D-erythro-7,8- complex 4-hydroxybenzoate 4-hydroxybenzoate MADE_RS02830 )-methyltransferase 20a) synthase betB proteolytic dehydrogenase: a (2E)-dodec- trans-2- benzene-1,2-diol sulfurtransferase: GTP lipoyl transferase 5'-deoxynucleotidase: RlmF: rlmF RsmG: rsmG fre dihydroneopterin porphobilinogen subunit alpha octaprenyltransferase: octaprenyltransferase: beta-N- an N 6 - an N 7 - DusA: dusA subunit ClpP: clpP glpD [+ 3 isozymes] 2-enoyl-[acp] decenoyl-ACP MADE_RS13230 synthase: lipA LipB: lipB yfbR β bifunctional 2- chorismate FadJ: fadJ ubiA ubiA 1618 527 20 -alanine an alcohol reduced riboflavin isomerase: fabA a [cysteine desulfurase]- dihydroneopterin synthase: hemB acetylhexosaminidase: nagZ methyladenine methylguanine a uracil in tRNA a peptide DHAP polyprenyl-6- 2'-deoxyadenosine S-sulfanyl-[disordered- aldolase: folB bifunctional (S)-3- a [glycine-cleavage in 23S rRNA in 16S rRNA a (2E,7Z)-tetradeca- hydroxyphenol aminodeoxychorismate/ a [glycine-cleavage form scaffold 3,4-dihydroxy- porphobilinogen hydroxybutanoyl-CoA an unsulfurated complex H protein] 3-decaprenyl-4- 3-hexaprenyl-4- 2,7-dienoyl-[acp] methylase/3- 6-(hydroxymethyl) anthranilate synthase 5'-deoxyadenosine complex H protein] N 6 acyl-carrier protein protein] complex 2-butanone-4- met 6 chitin N-acetyl-D-glucosamine cysteine -7,8-dihydropterin component II: fatty acid [sulfur carrier] N -octanoyl-L-lysine hydroxybenzoate hydroxybenzoate demethylubiquinol 3- phosphate synthase/ hydroxymethylbilane -[(R)-lipoyl]-L-lysine a dodecanoyl-[acp] O-methyltransferase desulfurase: 2-amino-4-hydroxy-6- MADE_RS07035 oxidation GTP cyclohydrolase synthase: hemC superpathway of thiamine diphosphate biosynthesis I MADE_RS13210 hydroxymethyldihydropteridine complex UbiG: ubiG [+ 2 isozymes] II: MADE_RS12725 all-trans- 966 type-1 diphosphokinase: folK subunit alpha a [pyruvate dehydrogenase E2 AsbD acyl- a guanine a [protein]- a (7Z)-tetradec- bifunctional 2- [+ 2 isozymes] 4-amino-4- preuroporphyrinogen coenzyme A [DNA] coenzyme A (S)-5-hydroxyisourate an oligopeptide MeOH glyoxal beta-ketoacyl- an S-sulfanyl-[cysteine GTP cyclohydrolase FadJ: fadJ a sulfurated [sulfur carrier] SAM protein] N 6 -octanoyl-L-lysine 4-hydroxybenzoate nonaprenyl dGMP acyl-carrier protein in 16S rRNA transmembrane L-histidine 7-enoyl-[acp] 2-amino-4-hydroxy-6- deoxychorismate cys carrier protein ACP synthase polyprenyl-6- desulfurase]-S- II: ribA uroporphyrinogen- diphosphate 16S rRNA proteins rhomboid family histidine kinase: catalase/ isoprenoid hydroxymethyldihydropteridine acetoacetyl-CoA 5'-deoxynucleotidase: ACP S- hydroxyisourate oligopeptidase B: I: fabB beta-ketoacyl- hydroxyphenol sulfanyl-[disordered- aminodeoxychorismate 2,5-diamino-6-(5-phospho-D- III synthase: (guanine(966)-N(2) intramembrane MADE_RS09805 peroxidase biosynthesis laurate diphosphokinase: folK cysteine yfbR malonyltransferase: hydrolase: uraH MADE_RS12290 beta-ketoacyl- ACP synthase methylase/3- form scaffold lyase: pabC ribosylamino)pyrimidin-4(3H)-one MADE_RS00725 holo-ACP exodeoxyribonuclease 4-hydroxybenzoate CoA pyrophosphatase: )-methyltransferase HPI: katG glyoxalase (7,8-dihydropterin- desulfurase: acetyl-CoA C- fabD serine protease [+ 5 isozymes] II: fabF demethylubiquinol 3- protein] complex lipoyl synthase: lipA synthase: I: sbcB MADE_RS09960 5'-deoxynucleotidase: 2 RsmD: rsmD (S)-2-oxo-4- a [protein]- [+ 2 isozymes] ElbB: elbB ACP synthase long-chain- 6-yl)methyl bifunctional acyltransferase octaprenyltransferase: an N - cleaved type-1GlpG: glpG O-methyltransferase [cysteine desulfurase]-S- 4-aminobenzoate uroporphyrinogen-III MADE_RS13210 MADE_RS03960 yfbR hydroxy-4-carboxy- a peptide N-phospho- II: fabF fatty-acid-- beta-ketoacyl- diphosphate diaminohydroxyphosphoribosylaminopyrimidine FadA: fadA ubiA a malonyl-[acp] methylguanine 966 transmembrane formaldehyde glycolate UbiG: ubiG sulfanylcysteine:[acceptor [+ 2 isozymes] L-histidine ACP synthase a 2'- 2'-deoxyguanosine in 16S rRNA 5-ureidoimidazoline CoA ligase 2-methoxy- protein]-cysteine deaminase/5-amino-6-(5-phosphoribosylamino) uroporphyrinogen an [L-cysteine [+ 2 isozymes] proteins I: fabB uracil reductase RibD: ribD a [pyruvate dehydrogenase a holo-[AsbD acyl- deoxyribonucleoside [DNA] 3',5'-ADP 4'-phosphopantetheine a 3-oxotetradecanoyl- FadD: fadD 6-(all-trans- sulfurtransferase: decarboxylase: hemE desulfurase]-S- 5'-deoxyadenosine 3',5'-ADP 3-nonaprenyl-4- acetyl-CoA met E2 protein] N 6 -lipoyl-L-lysine an unsulfurated [sulfur carrier] carrier protein] 5'-monophosphate [acp] a (9Z)-3-oxohexadec- octaprenyl)phenol a [cysteine MADE_RS13230 5-amino-6-(5-phospho- sulfanyl-L-cysteine a [ThiS sulfur- hydroxybenzoate lauroyl-CoA cysteine 9-enoyl-[acp] desulfurase]-(S- 7,8- D-ribosylamino)uracil coproporphyrinogen III carrier protein] desulfurase: sulfanyl) -[disordered- dihydropteroate bifunctional 2 D-ribulose 5-phosphate oxygen-dependent MADE_RS13210 phenylmercury acetate degradation Detoxification arsenate arsenate arsenate UDP-N-acetyl-α-D-glucosamine undecaprenyl-diphospho-N an [HPr]- phosphoenol all-trans- a 2'- a guanine 46 a negatively a [protein]-L- 2-methoxy-6-all form scaffold bifunctional diaminohydroxyphosphoribosylaminopyrimidine coproporphyrinogen a lipid II a ribonucleoside a single a holo [PedN acyl- propionamide ethanol a D-hexose a (3R)-3- [+ 2 isozymes] detoxification detoxification detoxification V -acetylmuramoyl-L-alanyl-γ- L-histidine pyruvate heptaprenyl deoxyribonucleoside in tRNA supercoiled DNA proline (ω = 180) asp trans-octaprenyl- protein] complex tetrahydrofolate bifunctional deaminase/5-amino-6-(5-phosphoribosylamino) oxidase: hemF mercuriphenyl 4-hydroxybenzoate triphosphate stranded DNA carrier protein] hydroxytetradecanoyl- a (3R,9Z)-3- D-glyceraldehyde a [ThiI sulfur- a carboxy- II (glutaredoxin) III (thioredoxin) D-glutamyl-L-lysyl- D-alanine diphosphate 5'-monophosphate tRNA DNA peptidylprolyl amidase: catalase/ 1,4-benzoquinol synthase/ 3,4-dihydroxy- uracil reductase RibD: ribD acetate reactive oxygen species degradation 5'-deoxynucleotidase: aspartate/ glucokinase: [acp] hydroxyhexadec- carrier protein]-S- adenylated-[ThiS arsenate ACP S- (guanosine(46)-N7) topoisomerase isomerase: MADE_RS07840 peroxidase dihydrofolate 5-amino-6-(5-phospho- protoporphyrinogen IX tyr 3-phosphate undecaprenyldiphospho- yfbR tyrosine/aromatic glk bifunctional 2-butanone-4- sulfanyl-L-cysteine sulfur-carrier protein] arsenate arsenate phosphoenolpyruvate- penicillin-binding malonyltransferase: -methyltransferase bifunctional 3- 9-enoyl-[acp] synthase: folC glyceraldehyde- muramoylpentapeptide beta-N- 4-hydroxybenzoate IV subunit B: parE MADE_RS03500 aminotransferase: amidase: HPI: katG demethylmenaquinone phosphate synthase/ D-ribitylamino)uracil 1-deoxy-D- organomercurial arsenate superoxide arsenate -protein protein 2: mrdA DNA primase: 5'-deoxynucleotidase: fabD hydroxydecanoyl- 3-hydroxyacyl- a [cysteine desulfurase]- 3-phosphate octaprenyltransferase: 7 TrmB: trmB [+ 2 isozymes] [+ 10 isozymes] MADE_RS19100 [+ 2 isozymes] 7,8-dihydrofolate GTP cyclohydrolase 2-iminoacetate xylulose-5- lyase MerB: merB reductase acetylglucosaminyltransferase: phosphotransferase: ptsP MADE_RS03695 yfbR a malonyl[PedN an N - MADE_RS11050 D-hexose 6- ACP dehydratase/ ACP methyltransferase/2- [scaffold protein- reductase a [protein]-L- AIR dehydrogenase: murG ubiA a 2'- acyl-carrier methylguanine 46 a relaxed DNA propanoate acetaldehyde phosphate methoxy-6-polyprenyl- monoglutamate II: MADE_RS12725 synthase phosphate organomercurial (glutaredoxin) (glutaredoxin) proline (ω = 0) oxaloacetate trans-2- dehydratase (2Fe-2S)] complex superoxide MADE_RS11600 a N-acetylglucosamine--N- deoxyribonucleoside 1,4-benzoquinol ThiH: thiH synthase: dxs lyase MerB: merB : arsC : arsC 1-arseno-3- an [HPr protein]- protein] in tRNA decenoyl-ACP FabZ: fabZ 1-deoxy-L-glycero- protoporphyrin IX phosphomethylpyrimidine a thiocarboxylated- dismutase [Fe]: sodB ditrans,octacis-undecaprenyldiphospho- UDP π D-ala acetylmuramyl-(tetrapeptide) ssDNA/pppN(pN) methylase UbiE: ubiE ARP 1-deoxy-D-xylulose [ThiS sulfur- arsenate arsenite phosphoglycerate N -phospho- pyruvate 3-heptaprenyl-4- isomerase: fabA bifunctional 3- tetrulose 4-phosphate synthase ThiC: thiC 2-iminoacetate N-acetyl-(N-acetylglucosaminyl)muramoyl- pyrophosphoryl-undecaprenol hybrid 6-methoxy-3- 5-phosphate hydrogen peroxide L-histidine hydroxybenzoate n -1 ferrochelatase: carrier protein] 2+ reductase ArsC: 3-hydroxyacyl- hydroxydecanoyl- a [co-chaperone]- acetate benzene Hg L-alanyl-γ-D-glutamyl-L-lysyl-D-alanine methyl-2-all- a 7,8-dihydrofolate HMP-P MADE_RS15240 ACP ACP dehydratase/ 6,7-dimethyl-8- MADE_RS18215 8-oxo-(d)GTP detoxification I trans-octaprenyl- [scaffold protein- thiazole synthase: mercury(II) arsenite dehydratase trans-2- ribityllumazine catalase: 1-arseno-3- 1,4-benzoquinol (2Fe-2S)] complex MADE_RS00690 UDP-N-acetyl-α-D-glucosamine undecaprenyl-diphospho-N-acetylmuramoyl-L- 6-[1-hydroxyethyl]-7- a 2,3,4-saturated (S)-2-oxo-4- guanine 37 a monocarboxylic an adenine 34 dihydrofolate protoheme phosphomethylpyrimidine reductase: MADE_RS02480 H + hydrogencarbonate + a holo [PedD acyl- methylglyoxal a glycogen FabZ: fabZ decenoyl-ACP synthase: ribE arsenite phosphoglycerate alanyl-γ-D-glutamyl-L-lysyl- D-alanyl-D-alanine 1,2-diacyl-sn- FMN NAD(P)H H hydroxy-4-carboxy- Phe L-cysteate reductase: folA kinase: thiE coenzyme A biosynthesis MADE_RS05035 methyl-7,8-dihydropterin carrier protein] in tRNA acid amide purine in tRNA isomerase: fabA 2-[(2R,5Z)-2-carboxy- [+ 2 isozymes] dGTP GTP 2-amino-4-hydroxy-6- glycerol 3-phosphate CTP 5-ureidoimidazoline tRNA amidase: aspartate/ glyoxalase: tRNA glycogen a (2E)-tetradec- I (prokaryotic) H O hydroxyl radical undecaprenyldiphospho- 2-oxo-4-hydroxy- [+ 2 isozymes] 2 ACP S- debranching a tetrahydrofolate HMP-PP 4-methylthiazol-5(2H)- hydroxymethyldihydropteridine (guanosine(37)-N1) MADE_RS07840 tyrosine/aromatic MADE_RS06660 adenosine(34) 2-enoyl-[acp] a (2E,9Z)-hexadeca- a [chaperone-ATP]- 6,7-dimethyl-8-(1-D-ribityl)lumazine muramoylpentapeptide beta-N- carbonic flavin reductase: 4-carboxy-5- xanthine ylidene]ethyl phosphate (R)-4'- 0 diphosphokinase: folK malonyltransferase: -methyltransferase aminotransferase: deaminase protein 2,9-dienoyl-[acp] 3-demethylubiquinol-8 [co-chaperone]- Hg arsenite O phosphatidate ureidoimidazoline amidase: dehydrogenase: glyoxalase: phosphopantothenate 2 acetylglucosaminyltransferase: anhydrase: MADE_RS16825 fabD GlgX: glgX 2-amino-4-hydroxy-6- 1 TrmD: trmD MADE_RS11050 TadA: tadA [scaffold protein- riboflavin synthase: pyridoxal 5'-phosphate biosynthesis I bifunctional arginine 8-oxo-dGTP 8-oxo-GTP murG cytidylyltransferase: decarboxylase: uraD a malonyl- an N - MADE_RS19100 xdhB xdhA MADE_RS07615 phosphatidylglycerol thiamine MADE_RS05610 [+ 2 isozymes] a hypoxanthine bifunctional 2- MADE_RS12730 dependent hydroxymethyldihydropteridine MADE_RS04905 37 a monocarboxylate 3-sulfopyruvate (R)-lactate a maltodextrin (2Fe-2S)] complex phosphopantothenoylcysteine (S)-(+)-allantoin [PedD acyl- methylguanine 8-hydroxypurine 34 biosynthesis II (non-plastidic) D-erythrose phosphate 8-oxo-dGTP in tRNAs polyprenyl-6- decarboxylase/ acid resistance diphosphokinase: folK carrier protein] Phe synthase: thiE [1-(2-amino-7-methyl-4-oxo- in tRNA a myristoyl-[acp] hydroxyphenol adenosylcobalamin riboflavin 4-phosphate diphosphatase ditrans,octacis-undecaprenyldiphospho-N- UDP NAD de novo phosphopantothenate-- 7,8-dihydro-3H-pteridin- CO H O FMNH NAD(P) + DHAP arg MutT: mutT acetyl-(N-acetyl-β-D-glucosaminyl)muramoyl-L- 2 2 a CDP-2,3,4-saturated- 2 a palmitoleoyl-[acp] methylase/3- biosynthesis I salvage from cobalamin cysteine ligase CoaBC: coaBC Nucleoside and Nucleotide Degradation bifunctional erythrose-4- (R)-4'- γ 6-yl)]ethyl diphosphate diacylglycerol beta-ketoacyl- NAD(P)H- demethylubiquinol 3- a [chaperone- biosynthetic 8-oxo-GMP alanyl- -D-glutamyl-L-lysyl-D-alanyl-D-alanine (from aspartate) riboflavin kinase/ phosphate thiamine phosphate phosphopantothenoyl- 8-oxo-dGMP ACP synthase dependent O-methyltransferase an [2Fe-2S] ADP]-[disordered- cob(I)alamin arginine FAD synthetase: ribF dehydrogenase: L-cysteine purine nucleotides degradation II (aerobic) I: fabB glycerol-3- UbiG: ubiG cluster protein asp adenosylcobinamide-GDP purine ribonucleosides degradation decarboxylase: form scaffold epd thiamine- an N-terminal L- a cytosine 967 a guanine 37 an adenosine 34 phosphate bifunctional dethiobiotin a sulfurated an L-arginyl- phylloquinone NAD(P)H H + an isoprenoid a 1-haloalkane uroporphyrinogen-III pyrazinamide protein] complex phosphate salvage from cobinamide I speA SAM 3-oxopropanoate L-ornithine Arg2 7,8-dihydropterin beta-ketoacyl- L-aspartate FMN 4-phospho- aspartyl-[protein] Arg 4-hydroxybenzoate in 16S rRNA in tRNA in [tRNA ] dehydrogenase: bifunctional 2- phosphopantothenoylcysteine agmatine [sulfur carrier] [tRNA ] diphosphate hypoxanthine ACP synthase palmitoleate oxidase: nadB cob(II)alamin D-erythronate kinase: thiL AMP uroporphyrinogen-III 16S rRNA tRNA malonic amidase: tRNA guanine gpsA polyprenyl-6- decarboxylase/ II: fabF 2-iminosuccinate bifunctional cob(II)inamide adenosine C-methyltransferase: (cytosine(967)-C(5) (guanosine(37)-N1) semialdehyde arginine N- MADE_RS07840 adenosine(34) sn-glycerol hydroxyphenol 4-phosphoerythronate phosphopantothenate-- NAD(P)H:quinone haloalkane xanthine deaminase: riboflavin kinase/ thiamine diphosphate cob(I)yrinic acid 4-hydroxybenzoate cobA )-methyltransferase -methyltransferase reductase: succinyltransferase: deaminase 3-phosphate methylase/3- cob(I)yrinic acid dehydrogenase: cysteine ligase CoaBC: coaBC GMP/IMP biotin arginyltransferase: dehydrogenase: amidase: guaD a 3-oxohexadecanoyl- an [Fe-S cluster quinolinate FAD synthetase: ribF a,c-diamide adenosine oxidoreductase: dehalogenase: astA a,c-diamide synthase octaprenyltransferase: [+ 2 isozymes] RsmB: rsmB 1 TrmD: trmD MADE_RS16830 MADE_RS19100 TadA: tadA demethylubiquinol 3- MADE_RS12050 nucleotidase: MADE_RS09070 an N - 2 xdhB xdhA 7,8- [acp] glycerol-3- biosynthesis synthase adenosyltransferase: deaminase: wrbA MADE_RS08575 a 5-methylcytosine 967 N -succinyl- pyrazine-2- an inosine 34 adenosyltransferase: 4'-phosphopantetheine BioB: bioB ubiA precorrin-2 37 3-hydroxypropanoate 6,8- O-methyltransferase chaperone]-ATP FAD yrfG methylguanine Arg2 dihydrolumazine phosphate 1-O- NadA: nadA (3R)-3-hydroxy-2-oxo- [corrinoid MADE_RS08105 MADE_RS07775 in 16S rRNA L-ornithine dihydroxypurine carboxylate in [tRNA ] UbiG: ubiG MADE_RS08105 an N-terminal in tRNA acyltransferase cob(II)alamin- 4 phosphooxybutanoate adenosyltranferase]- pantetheine- adenosine quinolinate adenosine biotin 5'-deoxyadenosine an unsulfurated a tRNA Arg L-arginiyl-L- NAD(P) + phylloquinol a 4-hydroxy-3- a halide anion a primary alcohol PlsY: plsY [corrinoid 3-phosphoserine/ cob(II)inamide phosphate deaminase: add met a (3R)-3- ubiquinol-8 [sulfur carrier] aspartyl-[protein] polyprenylbenzoate a 1-acyl-sn adenosyltranferase] phosphohydroxythreonine adenylyltransferase: hydroxyhexadecanoyl- -glycerol 3- carboxylating adenosine transaminase: serC D-glyceraldehyde coaD xanthosine adenosine inosine guanosine [acp] nicotinate- pyruvate deaminase: GMP IMP phosphate 4-phosphooxy- 3-phosphate 3'-dephospho- bifunctional 3- nucleotide [corrinoid MADE_RS07775 an N 10 - an N-terminal L- S-(2-hydroxyacyl) uridine 955/2504/ a cytosine 1962 phosphoenol 1-acyl-sn-glycerol- an L-arginyl- + sucrose a [protein] (L-serine/L- 54 an aromatic diphosphorylase: cob(I)alamin- L-threonine adenosyltranferase]- CoA phe NAD(P)H a plastoquinone H a uracil in tRNA D-ala DNA with lesion N5-CAIR hydroxydecanoyl- IMP formyltetrahydrofolate glutamyl-[protein] Arg glutathione 2580 in 23S rRNA in 23S rRNA threonine) phosphate pyruvate 3-phosphate bis(guanylyl molybdopterin) 1-deoxy-D- adenosine GMP/IMP [tRNA ] amino acid ACP dehydratase/ nadC [corrinoid 4-hydroxythreonine- cob(I)inamide dephospho- pyrimidine/purine pyrimidine/purine pyrimidine/purine pyrimidine/purine 23S rRNA ribosomal RNA protein tRNA excinuclease 5-(carboxyamino) acyltransferase: cofactor sulfurylation deaminase: nucleotidase: dehydrogenase: aspartate/ adenosyltranferase] 4-phosphate xylulose-5- cob(I)yrinic acid CoA kinase: nucleoside nucleoside nucleoside nucleoside pseudouridine(955/ large subunit (uridine(54)-C5)- D-alanine--D- ABC subunit imidazole pyruvate trans-2- MADE_RS11040 add yrfG guaB NAD(P)H:quinone sucrose phosphatase tyrosine/aromatic NaMN cob(I)yrinic acid dehydrogenase phosphate a,c-diamide coaE phosphorylase: phosphorylase: phosphorylase: phosphorylase: phenylalanine 4- hydroxyacylglutathione 2504/2580) methyltransferase methyltransferase alanine ligase: UvrB: uvrB ribonucleotide kinase: pyk decenoyl-ACP arginyltransferase: oxidoreductase: phosphorylase: CheZ: aminotransferase: 1-acylglycerol- synthase: dxs monooxygenase: synthase RluC: rluC I: MADE_RS08335 TrmA: trmA MADE_RS14900 mutase: purE isomerase: fabA cys nicotinate a,c-diamide PdxA: pdxA adenosyltransferase: MADE_RS05595 MADE_RS05595 MADE_RS05595 MADE_RS05595 MADE_RS09070 MADE_RS11950 hydrolase: gloB MADE_RS05540 MADE_RS11050 [+ 3 isozymes] 3-phosphate O- coenzyme A inosine guanosine XMP wrbA a pseudouridine 955/ 1962 a 5-methyluracil 54 DNA without pyruvate adenosyltransferase: 3-amino-1- MADE_RS08105 MADE_RS05725 a 5-methylcytosine D-alanyl-D-alanine an aromatic CAIR 3-hydroxyacyl- acyltransferase: (nicotinamide) a [protein] Ser/Thr cysteine MADE_RS08105 hydroxyacetone 1-deoxy-D-xylulose 2504/2580 in 23S rRNA in 23S rRNA in tRNA 2-oxo-acid lesion ACP MADE_RS15705 nucleotide GMP/IMP α-D-ribose-1-phosphate an N-terminal α-D- desulfurase: adenosylcob(III) 1-phosphate 5-phosphate adenosylcobinamide pyrimidine/purine pyrimidine/purine 4a-hydroxy-N 10 - β-D-fructofuranose a 2-hydroxy a 1,2-diacyl- adenylyltransferase: a tRNA Arg L-arginiyl-L- a plastoquinol NAD(P) + glucopyranose glutathione dehydratase MADE_RS13210 alamin-[corrinoid nucleoside nucleoside nucleotidase: pyrimidine deoxyribonucleosides degradation tyr carboxylate sn-glycerol nadD formyltetrahydrofolate glutamyl-[protein] FabZ: fabZ adenosyltranferase] pyridoxine 5'- phosphorylase: phosphorylase: yrfG 1-phosphate 3-phosphate [+ 2 isozymes] a (2E)-hexadec- an [L-cysteine nicotinate adenine cob(I)yrinic acid phosphate phosphopantothenate biosynthesis I MADE_RS05595 MADE_RS05595 2'-deoxycytidine phosphatidate dinucleotide xanthosine 2-enoyl-[acp] desulfurase]-S- a,c-diamide synthase: pdxJ adenosyl-cobinamide cytidylyltransferase: D-ribose 5-phosphate RNase R degradation (R)-S- UDP-4-amino-D-fucose a cytidine 34 in a double-stranded an organic dCTP sulfanyl-L-cysteine ammonia- ammonia- adenosyltransferase: hypoxanthine guanine cytidine Reactive Blue 5 a β-D-galactoside 2-hydroxyisobutyramide N-acetyl-L- molybdopterin biosynthesis phosphate 3-methyl-2-oxobutanoate glycyl-glycine glutathione met Ins(5)P thr MADE_RS04905 cysteine substrate RNA lactoylglutathione UDP-4-amino-4, 6- [elongator tRNA ] oligonucleotide hydroperoxide dCTP dependent dependent MADE_RS08105 deaminase: amidase: glutamate alkyl a CDP- bis(guanylyl pyridoxine 5'-phosphate dideoxy-N-acetyl- tRNA(Met) cytidine inositol-1- deaminase: desulfurase: NAD(+) NAD(+) folate transformations III (E. coli) 3-methyl-2-oxobutanoate pyrimidine/purine cdd oligoribonuclease: L-threonine 3- molybdopterin) adenosylcobalamin thymidine acetyltransferase: MADE_RS07840 acetylglutamate hydroperoxide diacylglycerol MADE_RS13210 synthetase: synthetase: hydroxymethyltransferase: xanthine guanine nucleoside Dyp-type gamma- beta-glucosidase: beta-L-altrosamine orn monophosphatase: dehydrogenase: dcd cofactor GTP pyridoxamine ribonuclease hydroxyacylglutathione amidase: reductase: panB pyrimidine/purine peroxidase: transaminase: pseC MADE_RS05835 suhB kinase: argB a palmitoyl-[acp] CDP-diacylglycerol-- [+ 2 isozymes] nadE nadE 5'-phosphate adenosylcobinamide- dehydrogenase: deaminase: phosphorylase: UTP and CTP dephosphorylation I 2'-deoxyuridine glutamyltransferase: ggt MADE_RS18440 R: rnr hydrolase: gloB tdh ahpC ahpF dUTP a tetrahydrofolate 4 34 MADE_RS19100 a nucleoside 5'- glycerol-3-phosphate 3- a [bis(guanylyl GDP xdhB xdhA guaD MADE_RS05595 nucleoside MADE_RS02295 [+ 2 isozymes] UDP-4-dehydro-6- an N -acetylcytidine 2-hydroxy-2- N-acetylglutamyl- + oxidase: pdxH met myo-inositol aminoacetone an alcohol molybdopterin) NAD GTP 3',8- 2-dehydropantoate UTP phosphorylase: deoxy-α-D-glucose in [elongator tRNA ] monophosphate phosphatidyltransferase: ATP pyrimidine/purine methylpropanoate phosphate pgsA cofactor [bis-MGD cofactor cys cyclase methionine synthase: MADE_RS05595 3-[(4-amino-6-chloro- D-galactopyranose a non galactosylated PLP 2-dehydropantoate 2- xanthine nucleoside 2,2'-disulfonyl γ-L-glutamyl- a diribonucleotide a nucleoside 5'- (R)-lactate glutathione 1-(3-sn- chaperone]-S- chaperone]- biotin biosynthesis from MoaA: moaA MADE_RS11395 CTP synthase: 1,3,5-triazin-2-yl) phthalate L-cysteinylglycine galactose acceptor reductase: MADE_RS06015 phosphorylase: thymine azobenzene glycylglycine monophosphate phosphatidyl) sulfanyl-L-cysteine bis-MGD cysteine molybdopterin- GTP 3',8- MADE_RS04635 palmitate 8-amino-7-oxononanoate I methionine 2-dehydropantoate 2- xanthine MADE_RS05595 amino]benzenesulfonate -sn-glycerol desulfurase: synthase cyclase dihydrofolatesynthase: metH reductase: MADE_RS06645 dehydrogenase UDP long-chain- 3-phosphate (8S)-8-amino-7- molybdenum cofactor biosynthesis MADE_RS13210 adenylyltransferase MoaA: moaA CTP reductase:serine folA accessory protein p-nitrophenyl- a [protein]- fatty-acid-- oxononanoateadenosylmethionine- [+ 2 isozymes] MoeB: moeB (8S)-3',8-cyclo-7,8- β-alanine D-glucopyranose maltopentaose maltotriose a glucan D-threo-7,8- a 5' triphospho- (1S,4R)-2,4,5-trichloro- a myo-inositol a [protein]- CTP phosphatidylglycerophosphatase (R)-pantoate XdhC: xdhC β oxaloacetate Ins(4)P wound RNA N-phospho- sulfo-bis(guanylyl an [L-cysteine a carboxy-adenylated dihydroguanosine a 7,8-dihydrofolatehydroxymethyltransferase:a 5-methyltetrahydrofolate asp dihydroneopterin -D-galactoside [mRNA] 2,5-cyclohexadiene-1-diol monophosphate L-glutamine CoA ligase A: MADE_RS12705 -8-amino-7- molybdate glycine cleavage system CAIR dCTP desulfurase]-S- [small subunit of MADE_RS12745 [+ 2 isozymes] RNA citrate synthase: ATP-dependent L-histidine chemoreceptor FadD: fadD an L-1- molybdopterin) oxononanoate 5'-triphosphate UMP haloalkane inositol-1- inositol-1- phosphohistidine deaminase: sulfanyl-L-cysteine molybdopterin synthase] aminomethyltransferase pantoate--beta-alanine CDP MADE_RS09575 RNA helicase glutamine cofactor transaminase: bioA predicted cyclic pyranopterin thymidylate urate uracil 2-deoxy-α- 4-alpha- 4-alpha- pyrophosphohydrolase: dehalogenase: monophosphatase: monophosphatase: dcd phosphatidyl- (7R,8S)- GcvT: gcvT a (6S)-5-formyltetrahydrofolate GMP/IMP dihydroneopterin beta-glucosidase: RhlB: rhlB phosphatase deamidase palmitoyl-CoA ABC monophosphate synthase: bifunctional ligase: MADE_RS17875 D-ribose 1- glucanotransferase: glucanotransferase: rppH MADE_RS08575 2-methylcitrate suhB suhB sn-glycerol molybdopterin nucleotidase: phosphoribosylaminoimidazolesuccinocarboxamide aldolase: folB MADE_RS18440 SixA: sixA CheD: cheD UTP diaminononanoate transporter synthase MADE_RS03325 methylenetetrahydrofolate5-formyltetrahydrofolate phosphate malQ malQ a 5'-phospho- (1S,4S)-2,5-dichloro-2,5- synthase: prpC [+ 3 isozymes] yrfG synthase: purC 1,2-dihydroxypropane- myo-inositol myo-inositol a [protein]- a [protein]-α- dethiobiotin of molybdate: MoaC: moaC dehydrogenase/ cyclo-ligase: (R)-pantothenate [mRNA] cyclohexadiene-1,4-diol an unwound RNA L-histidine a thiocarboxylated methylenetetrahydrofolate CMP 1,2,3-tricarboxylate L-glutamate tetrahydromonapterin synthase: bioD modB modA methenyltetrahydrofolateMADE_RS14670 uridine [small subunit of cyclic pyranopterin reductase: metF maltose maltotetraose a glucan D-glucopyranose 6-(hydroxymethyl) glycolaldehyde D-galactopyranose 4-nitrophenol biosynthesis cyclohydrolase FolD: folD type III pantothenate GMP/IMP [+ 2 isozymes] molybdopterin phosphate pyrimidine deoxyribonucleotides pyrimidine SAICAR -7,8-dihydropterin dethiobiotin molybdopterin synthase] a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate nucleotidase: purine deoxyribonucleosides degradation I adenine kinase: MADE_RS17135 dephosphorylation ribonucleosides molybdate nucleoside triphosphate yrfG GTP biotin dinucleotide molybdopterin bifunctional degradation (R)-4'-phosphopantothenate cytidine methylenetetrahydrofolate pyrophosphohydrolase: cytidine an (S-diacyl-sn- 1518 GTP synthase synthase an L-1- XLXG xyloglucan DNA combined with adenine / 3-heptaprenyl-4- (R)-3- a supercoiled dimethyl(3- uridine dehydrogenase/ mazG cytidine 2'-deoxyadenosine D-glucopyranose maltohexaose β-lindane 4-guanidinobutyramide Ins(2)P CAIR BioB: bioB molybdopterin catalytic subunit glyceryl)-L-cysteinyl- oligosaccharide exogenous DNA to form 1519 hydroxybenzoate oxopropyl) cyclohydrolase dCTP dCMP deaminase: cdd phosphatidylethanolamine adenine in 16S rRNA hydroxybutanoate duplex DNA molybdotransferase MoaE: moaE NAD salvage pathway I (PNC VI cycle) heme b biosynthesis II methenyltetrahydrofolate adenosine [apolipoprotein] a recombinational junction 16S rRNA 4-hydroxy-3- haloalkane amidase: 3-hydroxybutyrate ATP-dependent sulfanium 5-(carboxyamino) uridine 7,8-dihydroneopterinI FolE: folE 9-mercaptodethiobiotin dipyrromethane uridine Holliday junction inositol-1- betaine-aldehyde MoeA: (oxygen-independent) cyclohydrolase FolD: folD deaminase: 4-alpha- (adenine(1518)-N(6)/ polyprenylbenzoate dehalogenase: MADE_RS07840 dehydrogenase: DNA helicase: imidazole kinase: udk 3'-triphosphate cofactor biosynthesis beta-glucosidase: resolvase RuvX: ruvX monophosphatase: dehydrogenase: MADE_RS10860 + dUTP diphosphatase: pyrimidine/purine MADE_RS07775 adenine(1519)-N(6))- amidase: MADE_RS12370 ribonucleotide biotin molybdopterin NAD 10 NAD salvage pathway III apolipoprotein N- glucanotransferase: crossover junction decarboxylase: ubiD MADE_RS08575 MADE_RS07140 suhB dihydroneopterin NAD(+) an N -formyltetrahydrofolate MADE_RS11440 nucleoside adenosine MADE_RS18440 betB UMP synthase molybdopterin an apo-[hydroxymethylbilane uroporphyrinogen-III (to nicotinamide riboside) acyltransferase: lnt malQ endodeoxyribonuclease dimethyltransferase 2,3,4,5,6- MADE_RS19100 [+ 4 isozymes] mutase: purE triphosphate 2'- diphosphatase: nudC phosphorylase: 2-heptaprenylphenol acetoacetate myo-inositol a single synthase]-L-cysteine uroporphyrinogen nucleoside triphosphate 2'-deoxyinosine deaminase: add 2'-deoxyguanosine 6 RsmA: rsmA1518 4-guanidinobutanoate DMSP AIR BioB: bioB molybdotransferase ammonia-dependent pyrimidine/purine resolution of recombinationalRuvC: ruvC N -dimethyladenine pentachlorocyclohexanol epimerase: folX + MADE_RS05595 stranded DNA MoeA: moeA decarboxylase: hemE NADP pyrophosphohydrolase: XXXG xyloglucan 6 1519 NAD(+) synthetase: nadE nucleoside a 2-acyl-1-lyso- an N-acyl-(S-diacyl- D-galactopyranose junction formation /N -dimethyladenine 7,8-dihydromonapterin biotin mazG maltopentaose maltose oligosaccharide a [hydroxymethylbilane ammonia-dependent coproporphyrinogen III uracil phosphorylase: sn-glyceryl)-L- of two intact strands in 16S rRNA triphosphate MoO - dUTP dUMP phosphatidylethanolamine 2 synthase] ES intermediate NAD(+) synthetase: nadE pyrimidine/purine pyrimidine/purine cysteinyl-[lipoprotein] 2 menaquinol-7 biosynthesis MADE_RS05595 molybdopterin oxygen-independent + cytidylyl molybdenum nucleoside nucleoside hydroxymethylbilane nicotinate adenine dinucleotide NMN NAD S-methyl-5'-thioadenosine cofactor coproporphyrinogen all-trans- cofactor sulfurylation phosphorylase: phosphorylase: synthase: hemC 5-hydroxy-CTP 5-hydroxy-CMP degradation IV XXLG xyloglucan 2604 65 1939 RNase E III oxidase: hemN heptaprenyl 1,4-dihydroxy- NAD(+) MADE_RS05595 MADE_RS05595 3-methyl-2- 5,10-methylene- D-glucopyranose a maltodextrin a 1,4-β-D-glucan a uridine a uridine a uracil cytidine nicotinate (nicotinamide) cytidylyl molybdenum N,N'-diacetylchitobiose N-ethylmaleimide Ins(6)P thr degradation ser D-threo-7,8- a [hydroxymethylbilane diphosphate 2-naphthoate diphosphatase: S-methyl-5'- oxobutanoate tetrahydromethanopterin oligosaccharide in 23S rRNA in tRNA in 23S rRNA nucleotide protoporphyrinogen IX cofactor (trioxo) beta-hexosaminidase: substrate mRNA uridine dihydroneopterin synthase] ES intermediate nudC thioadenosine 2-deoxy-α-D- 23S rRNA tRNA 23S rRNA inositol-1- folate polyglutamylation 3 adenylyltransferase: nadD MADE_RS02830 alkene reductase: serine/threonine serine/threonine 5'-methylthioadenosine/ ribose 1-phosphate 3-methyl-2-oxobutanoate 4-alpha- exo 1,3/1,4-beta-D- pseudouridine(2604) pseudouridine(65) (uracil(1939)-C(5)) monophosphatase: ribonuclease kinase: udk dihydromonapterin hydroxymethylbilane NMN an [MCD cofactor beta-glucosidase: beta-N- MADE_RS15570 dehydratase: dehydratase: S-adenosylhomocysteine hydroxymethyltransferase: glucanotransferase: glucan glucohydrolase: synthase RluF: rluF synthase TruC: truC -methyltransferase suhB E: rne reductase: folM synthase: hemC NaMN nicotinamide chaperone]-MCD MADE_RS18440 acetylhexosaminidase: MADE_RS16755 MADE_RS16755 CMP a tetrahydrofolate nucleosidase: panB malQ MADE_RS18430 a pseudouridine 2604 a pseudouridine 65 RlmD: rlmD GMP/IMP a 5-methyluracil 1939 5,6,7,8- a [hydroxymethylbilane demethylmenaquinol-7 cysteine MADE_RS03860 nagZ N-ethylsuccinimide myo-inositol 2-oxobutanoate an mRNA fragment pyruvate protoporphyrin IX nucleotidase: in 23S rRNA in tRNA in 23S rRNA tetrahydromonapterin synthase] ES intermediate desulfurase: [+ 2 isozymes] XXXG xyloglucan N-acetyl-D-glucosamine serine 4 yrfG D-galactopyranose bifunctional bifunctional MADE_RS13210 MTR a maltodextrin maltose oligosaccharide a 1,4-β-D-glucan D-glucopyranose hydroxymethyltransferase: hydroxymethylbilane ferrochelatase: 1-(β-D 2-dehydropantoate THMPT tetrahydrofolate demethylmenaquinone [+ 2 isozymes] synthase: hemC bis(guanylyl molybdenum MADE_RS18215 ribofuranosyl) synthase/ MADE_RS12745 an N 10 - glutathione methyltransferase/2- a [cytidylyl molybdenum dihydrofolate a holo-[hydroxymethylbilane cofactor) biosynthesis methoxy-6-polyprenyl- nicotinamide formyltetrahydrofolate nicotinate biosynthesis cofactor chaperone]- Inorganic Nutrient Metabolism protoheme a plant soluble XLLG xyloglucan a long-linear 2605 13 a [protein]- synthase: folC a 5,10- synthase] MoO - 1,4-benzoquinol a generic D-glucopyranose α-D-glucopyranose a 23S rRNA uridine a uridine a double π a phosphate bifunctional 2 cytidylyl molybdenum α a [protein] Ser/Thr Ins(1)P N -phospho- thiosulfate methylenetetrahydrofolate molybdopterin methylase UbiE: ubiE polynucleotide substrate heteroglycan oligosaccharide -D-glucan uridine 1911/1915/1917 in 23S rRNA in tRNA stranded DNA monoester tetrahydrofolate molybdopterin cys glu cofactor (sulfo-dioxo) superpathway of sulfate assimilation and cysteine biosynthesis L-histidine nitrate reduction V (assimilatory) 23S rRNA 23S rRNA serine/threonine DNA/RNA thiosulfate bifunctional synthase/ cofactor selenate reduction tRNA inositol-1- phosphohistidine alkaline a tetrahydrofolate menaquinol-7 thiamine diphosphate pseudouridine(1911/ pseudouridine(2605) protein kinase: nuclease sulfurtransferase tetrahydrofolate dihydrofolate 4-alpha- beta-glucosidase: 4-alpha- pseudouridine(13) monophosphatase: phosphatase phosphatase: molybdenum cofactor biosynthesis 3-phospho-D-glycerate S1/P1 nuclease: 1915/1917) synthase RluB: rluB MADE_RS10015 SfsA: sfsA GlpE: glpE synthase/ synthase: folC tetrahydrofolate salvage from thioredoxin glutamate-- nitrate glucanotransferase: MADE_RS18440 glucanotransferase: synthase TruD: truD suhB SixA: sixA MADE_RS13365 guanylyltransferase: NAD II (Bacillus) selenate MADE_RS01020 synthase RluD: rluD 2605 13 dihydrofolate 5,10-methenyltetrahydrofolate pathway malQ malQ 1911/ a pseudouridine a pseudouridine a [protein] (L-serine/L- 10 cysteine ligase: glutathione- sulfate a pseudouridine a 5'-phosphooligonucleotide a [protein]- an alcohol sulfite an N - MADE_RS08425 phosphorylation and phosphoglycerate respiratory nitrate assimilatory in 23S rRNA in tRNA myo-inositol synthase: folC MADE_RS06035 HMP-PP sulfate 1915/1917 in 23S rRNA threonine) phosphate L-histidine formyltetrahydrofolate a 5,10- peroxide dehydrogenase: serA adenylyltransferase: an oxidized transhydrogenation thiamine reductase: narI sulfate reduction IV a plant soluble XXXG xyloglucan a short 1,4- thiamine a 5,10- methenyltetrahydrofolate lipoate biosynthesis redox reactions cysN cysD maltose D-galactopyranose bis(molybdenum thioredoxin + phosphate sulfate MADE_RS18670 a 5'-phosphomononucleotide a 5'-phosphooligonucleotide oligosaccharide diphosphate methylenetetrahydrofolate bifunctional γ-L-glutamyl- NAD and incorporation I adenosine 5'- heteroglycan α-D-glucan cofactor) GSSG adenylyltransferase: 3-phosphooxypyruvate sulfate salvage I methylenetetrahydrofolate synthase: phosphoselenate L-cysteine NAD(+) nitrite dehydrogenase/ molybdenum cofactor thiE cysN cysD sulfate glutathione kinase: nadK 3-phosphoserine/ thiamine bis(guanylyl tungstenpterin) an octanoyl-[acp] thiamine adenylyltransferase: 1915 55 a [protein]- methenyltetrahydrofolate guanylyltransferase: thioredoxin- + 5-amino-4- a pseudouridine 3-phenyl-2- 3-decaprenyl-4- D-ribulose a uridine (2R,3S)-3- NADP phosphohydroxythreonine D-glucopyranose maltotetraose τ a ribonucleoside 2+ cofactor biosynthesis synthase: lipoyl(octanoyl) phosphate APS cysN cysD PRPP a uridine in tRNA reduced riboflavin N -phospho- Fe cyclohydrolase FolD: folD MADE_RS08425 disulfide glutathione- transaminase: serC imidazolecarboxyamide in 23S rRNA oxopropanoate hydroxybenzoate 5-phosphate in tRNA isopropylmalate 5'-monophosphate menaquinol-8 biosynthesis an N 10 - bis(guanylyl gshB transferase APS tRNA dihydrouridine(16) 23S rRNA L-histidine reductase: NAD(P) thiamine- disulfide adenylyl-sulfate selenite 4-hydroxy-3- tRNA flavin reductase: 3-isopropylmalate GMP/IMP thiamine formyltetrahydrofolate synthase DusC: dusC 4-hydroxyphenylpyruvate phosphoribulokinase: phosphohistidine bacterioferritin: bfr molybdopterin) trxB glutathione transhydrogenase: a [lipoyl-carrier protein]LipB: lipB phosphate reductase: 4-alpha- (pseudouridine(1915)- polyprenylbenzoate pseudouridine(55) MADE_RS16825 dehydrogenase: phosphate GTP kinase: cysC O-phospho-L-serine ammonium adenylyl-sulfate dioxygenase: hppD MADE_RS19155 phosphatase nucleotidase: bacterioferritin: bfr bis(tungstenpterin) phosphoribosylglycinamide cofactor N 6 -octanoyl-L-lysine kinase: thiL gorA adenine tRNA dihydrouridine N(3))-methyltransferase demethylmenaquinol-8 MADE_RS18900 glucanotransferase: decarboxylase: ubiD synthase TruB: truB [+ 2 isozymes] leuB SixA: sixA yrfG thiamine- cofactor kinase: cysC phosphoribosyltransferase: apt RlmH: rlmH 55 bifunctional formyltransferase: purN MADE_RS18905 thiamine PAPS malQ synthase DusB: dusB an N 3 - (2-hydroxyphenyl) D-ribulose-1,5- a pseudouridine 4-methyl-2- lipoyl phosphoserine 2-decaprenylphenol riboflavin a [protein]- a ribonucleoside Fe 3+ phosphate a reduced glutamate- NADP-specific a 5,6-dihydrouridine in tRNA 1915 bisphosphate demethylmenaquinone synthase: lipA diphosphate phosphatase SerB: serB PAPS methylpseudouridine acetate in tRNA oxopentanoate L-histidine kinase: thiL molybdenum cofactor a tetrahydrofolate thioredoxin NADPH phosphoadenylyl- selenodiglutathione -ammonia glutamate methyltransferase/2- a [lipoyl-carrier glutathione in 23S rRNA guanylyltransferase: menaquinol-9 biosynthesis menaquinol-6 biosynthesis sulfate reductase: ligase: glnA dehydrogenase: AICAR maltose maltotriose thiamine methoxy-6-polyprenyl- protein]-N 6 -[(R)- phosphoadenylyl- MADE_RS08425 MADE_RS16410 ser gdhA diphosphate 1,4-benzoquinol dihydrolipoyl]-L-lysine sulfate reductase: glutamate methylase UbiE: ubiE demethylmenaquinol-9 demethylmenaquinol-6 guanylyl molybdenum sulfite serine O- MADE_RS16410 bis(guanylyl gln an N 6 -L- 4a-hydroxy-L- menaquinol-8 bifunctional bifunctional synthase large α a 4-hydroxy-3- (6R)-L-erythro-5,6,7,8- 8-phenyloctanoyl- cofactor biosynthesis acetyltransferase: cysE UDP-N-acetyl- -D-muramoyl- 37 carboxynorspermidine an α-limit dextrin starch a thiopurine DHAP NaMN tungstenpterin) cofactor glutathioselenol subunit: gltB sulfite D-alanyl-D-alanine threonylcarbamoyladenine erythro-5,6,7,8- 2-keto-D-gluconate demethylmenaquinone demethylmenaquinone assimilatory sulfite L-alanyl-γ-D-glutamyl-L-lysine polyprenylbenzoate tetrahydrobiopterin CoA MoO - serine O- in tRNA tetrahydrobiopterin 2,5-didehydrogluconate methyltransferase/2- methyltransferase/2- 2 reductase (NADPH): 4-hydroxy-3- 4-alpha- pteridine cyclomaltodextrin thiopurine S- acyl-CoA methylglyoxal GMP/IMP molybdopterin acetyltransferase: cysE octaheme sulfite tRNA cyclic N6- reductase DkgB: dkgB carboxynorspermidine methoxy-6-polyprenyl- methoxy-6-polyprenyl- cysI MADE_RS16420 4a-hydroxytetrahydrobiopterin polyprenylbenzoate glucanotransferase: reductase: glucanotransferase: methyltransferase: dehydrogenase synthase: nucleotidase: cofactor molybdenum cofactor reductase: cysI UDP-N-acetylmuramoyl- threonylcarbamoyladenosine(37) decarboxylase: nspC 1,4-benzoquinol 1,4-benzoquinol glu dehydratase: MADE_RS08655 2,5-didehydrogluconate decarboxylase: ubiD malQ MADE_RS07870 MADE_RS09670 tmpT FadE: fadE MADE_RS02530 yrfG guanylyltransferase: hydrogen sulfide O-acetyl-L-serine tripeptide--D-alanyl-D- synthase TcdA: tcdA a α-limit dextrin methylase UbiE: ubiE a cyclic N 6 -L- reductase DkgB: dkgB a 2-(all-trans- a thiopurine (2E)-phenyloct- β-D- methylase UbiE: ubiE guanylyl MADE_RS08425 hydrogen selenide hydrogen sulfide alanine ligase: murF (6R)-L-erythro-6,7- a cyclodextrin 2,5-didehydro-D-gluconate norspermidine with short branches L-erythro-biopterin methylglyoxal menaquinol-9 menaquinol-6 molybdenum threonylcarbamoyladenosine dihydrobiopterin polyprenyl)phenol S-methylether 2-enoyl-CoA ribosylnicotinate cysteine 37 in tRNA cofactor UDP-N-acetyl-α-D-muramoyl-L-alanyl- synthase A: cysK thiosulfate oxidation III γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine (multienzyme complex) assimilatory cys 2,5-diamino-6-(5- a (1->4)- sulfate reduction III phosphatidylglycerolphosphate a glucosylated glycogenin 2-keto-L-gulonate 3-nonaprenyl-4- dCMP (2R,3S)-3- 6,8- dCDP urea cycle a [SoxY protein]-L-cysteine phospho-D-ribitylamino) uroporphyrinogen-I 2-phosphoglycolate α-D-glucan D-glycerate (1-oleoyl, 2-palmitoyl) hydroxybenzoate 5'-deoxynucleotidase: isopropylmalate dihydroxypurine ribonucleoside- pyrimidin-4(3H)-one 1,4-alpha-glucan-branching 2,5-didehydrogluconate cyclomaltodextrin sulfate bifunctional 4-hydroxy-3- yfbR phosphoglycolate 3-isopropylmalate xanthine diphosphate phosphatidylglycerophosphatase protein: MADE_RS15865 reductase DkgB: dkgB uroporphyrinogen glucanotransferase: glycerate kinase: sulfate diaminohydroxyphosphoribosylaminopyrimidine polyprenylbenzoate phosphatase: dehydratase: dehydrogenase: reductase: arg A: MADE_RS12705 1,4-alpha-glucan branching 2,5-didehydrogluconate decarboxylase: hemE 5'-deoxynucleotidase: MADE_RS09670 MADE_RS15440 adenylyltransferase: deaminase/5-amino-6-(5-phosphoribosylamino) decarboxylase: ubiD MADE_RS10855 leuD leuC xdhB xdhA nrdA nrdB protein GlgB: glgB reductase DkgB: dkgB yfbR a [SoxY protein]-S- cysN cysD uracil reductase RibD: ribD 1-oleoyl-2-palmitoyl- a cyclodextrin (2S)-2- 2-phospho- APS 5-amino-6-(5-phospho- coproporphyrinogen I 2-nonaprenylphenol 2'-deoxycytidine glycolate urate CDP ammonium sulfosulfanyl-L-cysteine phosphatidylglycerol a glycogen 2,5-didehydro-D-gluconate isopropylmalate D-glycerate argininosuccinate D-ribitylamino)uracil phosphoadenylyl- lyase: argH glutamine- cytochrome c: sulfate reductase: hydrolyzing MADE_RS07205 UDP-2-acetamido-4-amino- UDP-4-amino-4-deoxy- MADE_RS16410 a 5-carboxymethylaminomethyluridine 34 4a-hydroxy-N 10 - a double dUMP D-sedoheptulose dTMP UDP carbamoyl- a cytidine 34 in tRNA 2,4,6-trideoxy-α-D-galactose β-L-arabinopyranose D-threo-isocitrate D-ribofuranose cellulose L-arginino- in tRNA Leu formyltetrahydrofolate stranded DNA 5'-deoxynucleotidase: 7-phosphate 5'-deoxynucleotidase: ribonucleoside- L-ornithine phosphate a [SoxY protein]-S- a [SoxY protein]-S sulfite UDP-4-amino-4, 6- UDP-4-amino-4, 6- succinate tRNA (uridine(34)/cytosine(34)/5- tRNA (uridine(34)/cytosine(34)/5- phosphoheptose isocitrate synthase: disulfanyl-L-cysteine -sulfanyl-L-cysteine 4a-hydroxytetrahydrobiopterin exodeoxyribonuclease dideoxy-N-acetyl- dideoxy-N-acetyl- yfbR yfbR ribokinase: endoglucanase: diphosphate carboxymethylaminomethyluridine(34) carboxymethylaminomethyluridine(34) isomerase: dehydrogenase: carA carB assimilatory sulfite dehydratase: MADE_RS08655 V: recD recB recC beta-L-altrosamine beta-L-altrosamine 5'-deoxynucleotidase: 5'-deoxynucleotidase: MADE_RS14655 MADE_RS16705 reductase: -2'-O)- methyltransferase TrmL: trmL MADE_RS15355 MADE_RS04790 reductase (NADPH): -2'-O)- methyltransferase TrmL: trmL transaminase: pseC transaminase: pseC yfbR yfbR nrdA nrdB carbamoyl 34 10 D-ribofuranose cysI MADE_RS16420 a 5-carboxymethylaminomethyl- a 2'-O-methylcytidine an N -formyl- UDP-2-acetamido-2,6- UDP-β-L-threo- D-glycero-D-manno- a cellodextrin phosphate a 5'-phosphooligonucleotide 2'-deoxyuridine thymidine 2-oxoglutarate dUDP argininosuccinate ornithine 2'-O-methyluridine 34 in tRNA Leu in tRNA 7,8-dihydrofolate dideoxy-α-D-xylo-hex-4-ulose pentapyranos-4-ulose heptose 7-phosphate 5-phosphate synthase: carbamoyltransferase: a [SoxY protein]-S-(2- hydrogen sulfide MADE_RS02510 MADE_RS02515 sulfodisulfanyl)-L-cysteine L-citrulline polyphosphate metabolism thiosulfate disproportionation long chain IV (rhodanese) polyphosphate phosphate acquisition thiosulfate exopolyphosphatase: a phosphate polyphosphate thiosulfate MADE_RS14285 kinase 1: ppk1 monoester sulfurtransferase exopolyphosphatase: ppx acid phosphatase: GlpE: glpE MADE_RS18515 phosphate thiocyanate sulfite long chain polyphosphate a reduced a reduced a reduced plastocyanin plastocyanin plastocyanin an oxidized a dicarboxylate a dicarboxylate molybdate molybdate an oxidized an oxidized a quaternary plastocyanin an amino an amino an amino an amino an amino a nicotinamide D-glucose 6- phosphonate plastocyanin plastocyanin an inorganic an inorganic phosphate ammonium molybdate a phospholipid (S)-lactate benzoate a nucleoside a nucleoside a lipopolysaccharide a lipopolysaccharide ammonium phosphate phosphate phosphate phosphate phosphate sulfate arsenite choline acid acid mononucleotide phosphate phosphite anion anion phosphate acid acid acid a lipopolysaccharide a polysaccharide a polysaccharide a polysaccharide a polysaccharide compound predicted predicted cytochrome- predicted ABC predicted ABC ABC ABC cytochrome cytochrome ModC MlaF RS05855 RS14280 RS07605 RS17610 RS03755 c oxidase, RS02045 RS16990 efflux transporter of efflux transporter of LptA RS03545 RS05615 RS02285 RS17610 RS04345 RS17080 RS11775 RS03785 PstA PstB RS04740 RS04755 RS07915 RS13680 CysZ ArsB BetT RS13870 RS16765 RS07580 RS08390 RS17060 RS06235 transporter transporter c oxidase c oxidase cbb3-type a lipopolysaccharide a lipopolysaccharide of molybdate of molybdate a quaternary a nicotinamide D-glucose phosphonate an inorganic an inorganic an amino an amino an amino molybdate a phospholipid (S)-lactate benzoate a nucleoside a nucleoside ammonium phosphate phosphate phosphate phosphate phosphate phosphate sulfate arsenite choline ammonium mononucleotide phosphite a lipopolysaccharide anion anion a polysaccharide a polysaccharide a polysaccharide a polysaccharide acid an amino an amino acid acid O O phosphate compound molybdate molybdate 2 2 O a lipopolysaccharide a lipopolysaccharide acid acid H O H O 2 2 2 H O a dicarboxylate a dicarboxylate 2 This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.