Interactions with PBC Agents
www.hep-druginteractions.org
Interactions with PBC Agents
Charts created November 2020. Full information available at www.hep-druginteractions.org Page 1 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.
Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Acid Acid Acid Acid Acid Acid Anaesthetics & Muscle Relaxants Antibacterials (continued) Antidepressants Bupivacaine Cloxacillin Agomelatine Cisatracurium Dapsone Amitriptyline Isoflurane Delamanid Bupropion Ketamine Ertapenem Citalopram Nitrous oxide Erythromycin Clomipramine Propofol Ethambutol Desipramine Thiopental Flucloxacillin Desvenlafaxine
Tizanidine Gentamicin Dosulepin Analgesics Imipenem Doxepin Aceclofenac Isoniazid Duloxetine Alfentanil Escitalopram Aspirin Levofloxacin Linezolid Fluoxetine Buprenorphine Lymecycline Fluvoxamine Celecoxib Imipramine Meropenem Codeine distribution. for Lithium Methenamine Dexketoprofen Maprotiline Metronidazole Dextropropoxyphene Mianserin Moxifloxacin Diamorphine Milnacipran Diclofenac Nitrofurantoin Mirtazapine Diflunisal Norfloxacin Moclobemide Dihydrocodeine Ofloxacin Nefazodone Etoricoxib Penicillin V Nortriptyline Fentanyl Piperacillin Paroxetine Flurbiprofen Pivmecillinam Sertraline
Hydrocodone distribution. for Not only. use ersonal Pyrazinamide Tianeptine Hydromorphone Rifabutin Ibuprofen Trazodone Rifampicin Indometacin Trimipramine Rifapentine Ketoprofen Venlafaxine Mefenamic acid Rifaximin Vortioxetine Meloxicam Spectinomycin Antidiabetics Metamizole (Dipyrone) Streptomycin Acarbose Methadone Sulfadiazine Albiglutide Morphine Tazobactam Alogliptin Naproxen Telithromycin Canagliflozin
Oxycodone Temocillin Not only. use For personal for distribution. Dapagliflozin Paracetamol Tetracyclines Dulaglutide Pethidine (Meperidine) Ticarcillin Empagliflozin Piroxicam Trimethoprim/Sulfamethoxazole Exenatide Tapentadol Troleandomycin Glibenclamide (Glyburide) Tramadol Vancomycin Gliclazide Anthelmintics Anticoagulant, Antiplatelet & Fibrinolytic Glimepiride Albendazole Acenocoumarol Glipizide Ivermectin Anagrelide Insulin Oxamniquine Apixaban Linagliptin Praziquantel Clopidogrel Liraglutide Pyrantel For p for distribution. Not only. use r personal Dabigatran Lixisenatide Antiarrhythmics Dalteparin Metformin Amiodarone Danaparoid Nateglinide Bepridil Dipyridamole Pioglitazone Digoxin Edoxaban Disopyramide Eltrombopag Repaglinide Dofetilide Enoxaparin Rosiglitazone Dronedarone Fluindione Saxagliptin Flecainide Fo distribution. Fondaparinux Sitagliptin Lidocaine (Lignocaine) Heparin Tolbutamide Mexiletine Phenprocoumon Vildagliptin Propafenone Prasugrel Antifungals Quinidine Rivaroxaban Amphotericin B Vernakalant Streptokinase Anidulafungin Antibacterials Ticagrelor Caspofungin Amikacin Ticlopidine Fluconazole Amoxicillin Tinzaparin Flucytosine Ampicillin Warfarin Griseofulvin Azithromycin Anticonvulsants Isavuconazole Aztreonam Carbamazepine Itraconazole Bedaquiline Clonazepam Ketoconazole Benzylpenicillin Eslicarbazepine For personal use only. Not for Not only. use For personal For personal use only. Not for distribution. For personal use only. Not Not only. use For personal for distribution. Not only. use For personal Miconazole Capreomycin Ethosuximide Nystatin Cefaclor Gabapentin Posaconazole Cefadroxil Lacosamide Cefalexin Lamotrigine Terbinafine Cefazolin Levetiracetam Voriconazole Cefixime Oxcarbazepine Cefotaxime Perampanel Cefradine Phenobarbital Ceftaroline Phenytoin Ceftazidime Pregabalin Ceftriaxone Primidone Cefuroxime Retigabine Chloramphenicol Rufinamide Ciprofloxacin Sultiame Clarithromycin Tiagabine Clavulanic acid Topiramate Clindamycin Valproate (Divalproex) Clofazimine Vigabatrin Zonisamide
Key to symbols Notes Further information is available at © Liverpool Drug Interactions Group, These drugs should not be coadministered www.hep-druginteractions.org University of Liverpool, Pharmacology Research Labs, Potential clinically significant interaction that is likely to require additional Predicted interactions are based on known 1st Floor Block H, 70 Pembroke Place, LIVERPOOL, L69 3GF monitoring, alteration of drug dosage or timing of administration metabolic pathways and routes of clearance. We aim to ensure that information is accurate and consistent with current knowledge Potential interaction likely to be of weak intensity. Additional Caution is required in patients with hepatic and practice. However, the University of Liverpool and its servants or agents shall action/monitoring or dosage adjustment is unlikely to be required impairment as this may also increase drug levels not be responsible or in any way liable for the continued currency of information in and require dose modification. this publication whether arising from negligence or otherwise howsoever or for any consequences arising therefrom. The University of Liverpool expressly exclude No clinically significant interaction expected Where advice differs between countries, the liability for errors, omissions or inaccuracies to the fullest extent permitted by law.
charts reflect the more cautious option.
www.hep-druginteractions.org
Interactions with PBC Agents
Charts created November 2020. Full information available at www.hep-druginteractions.org Page 2 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.
Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Acid Acid Acid Acid Acid Acid Antihistamines Antivirals Cancer Therapies Astemizole Aciclovir Abiraterone Bilastine Amantadine Acalabrutinib Cetirizine Brivudine Anastrozole Chlorphenamine Cidofovir Avelumab Desloratadine Foscarnet Axitinib Diphenhydramine Oseltamivir Bevacizumab Doxylamine Blinatumomab
Rimantadine Ebastine Valaciclovir Bortezomib Fexofenadine Zanamivir Bosutinib Hydroxyzine Brentuximab vedotin Anxiolytics/Hypnotics/Sedatives Levocetirizine Capecitabine Alprazolam Loratadine Carboplatin Amobarbital Promethazine Cetuximab Terfenadine Bromazepam for distribution. for Chlorambucil Antimigraine Agents Bromperidol Cisplatin Almotriptan Buspirone Cyclophosphamide Dihydroergotamine Clobazam Daratumumab Eletriptan Clorazepate Dasatinib Ergotamine Clotiapine Doxorubicin Frovatriptan Diazepam Erlotinib Methylergonovine Estazolam Estramustine Naratriptan Flurazepam Etoposide Pizotifen
ersonal use only. Not for distribution. for Not only. use ersonal Lorazepam Everolimus Rizatriptan Lormetazepam Exemestane Sumatriptan Midazolam (oral) Fludarabine Zolmitriptan Midazolam (parenteral) Gefitinib Antiprotozoals Oxazepam Gemcitabine Amodiaquine Idarubicin Artemether Quazepam Imatinib Artemisinin Temazepam Ipilimumab Artesunate Triazolam Irinotecan Atovaquone Zaleplon Ixazomib Chloroquine Zolpidem
for distribution. For personal use only. Not Not only. use For personal for distribution. Lapatinib Dihydroartemisinin Zopiclone Letrozole Doxycycline Beta Blockers Medroxyprogesterone Halofantrine Atenolol (oncology) Hydroxychloroquine Bisoprolol Mercaptopurine Lumefantrine Carvedilol Mesna Mefloquine Celiprolol Methotrexate Pentamidine Labetalol Primaquine Metoprolol Mitoxantrone Proguanil Nebivolol Nilotinib Pyrimethamine Oxprenolol Niraparib Quinine Nivolumab r personal use only. Not for distribution. For p for distribution. Not only. use r personal Pindolol Sodium stibogluconate Propranolol Obinutuzumab Sulfadoxine Sotalol Ofatumumab Antipsychotics/Neuroleptics Timolol Olaratumab Amisulpride Bisphosphonates Oxaliplatin Aripiprazole Alendronic acid Paclitaxel Panitumumab Asenapine Clodronate Pembrolizumab Chlorpromazine Ibandronic acid distribution. Fo distribution. Rituximab Chlorprothixene Pamidronate Clozapine Sorafenib Risedronate Flupentixol Sunitinib Fluphenazine Bronchodilators Tamoxifen Haloperidol Formoterol Temsirolimus Iloperidone Indacaterol Vinblastine Levomepromazine Ipratropium bromide Vincristine Lurasidone Montelukast Vinorelbine Olanzapine Omalizumab Contraceptives and Hormone Replacements Paliperidone Salbutamol Conjugated estrogens (HRT) Perazine Salmeterol Desogestrel (POP) Periciazine Theophylline Desogestrel/ethinylestradiol Perphenazine Tiotropium (COC) For personal use only. Not for Not only. use For personal Pimozide Not only. use For personal for distribution. Not only. use For personal Calcium Channel Blockers Dienogest Pipotiazine Amlodipine Drospirenone (POP) Prochlorperazine Diltiazem Quetiapine Drospirenone/estradiol Felodipine Risperidone (HRT) Nicardipine Drospirenone/estradiol Sulpiride Thioridazine Nifedipine (HRT) Nisoldipine Dydrogesterone/estradiol Tiapride Trifluoperazine Nitrendipine (HRT) Ziprasidone Verapamil Estradiol Zuclopentixol Ethinylestradiol Etonogestrel (implant) Etonogestrel (vaginal ring) Gestodene/ethinylestradiol (COC)
Key to symbols Notes Further information is available at © Liverpool Drug Interactions Group, These drugs should not be coadministered www.hep-druginteractions.org University of Liverpool, Pharmacology Research Labs, Potential clinically significant interaction that is likely to require additional Predicted interactions are based on known 1st Floor Block H, 70 Pembroke Place, LIVERPOOL, L69 3GF monitoring, alteration of drug dosage or timing of administration metabolic pathways and routes of clearance. We aim to ensure that information is accurate and consistent with current knowledge Potential interaction likely to be of weak intensity. Additional Caution is required in patients with hepatic and practice. However, the University of Liverpool and its servants or agents shall action/monitoring or dosage adjustment is unlikely to be required impairment as this may also increase drug levels not be responsible or in any way liable for the continued currency of information in and require dose modification. this publication whether arising from negligence or otherwise howsoever or for any consequences arising therefrom. The University of Liverpool expressly exclude No clinically significant interaction expected Where advice differs between countries, the liability for errors, omissions or inaccuracies to the fullest extent permitted by law.
charts reflect the more cautious option.
www.hep-druginteractions.org
Interactions with PBC Agents
Charts created November 2020. Full information available at www.hep-druginteractions.org Page 3 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.
Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycho Acid Acid Acid Acid Acid lic Acid Contraceptives and Hormone Replacements (cont) Gastrointestinal Agents Herbals/Supplements/Vitamins Levonorgestrel (COC) Aluminium hydroxide Aloe vera Levonorgestrel Alverine citrate Ascorbic acid (Vitamin C) (Emergency Contraception) Antacids Black cohosh (A. racemosa) Levonorgestrel (HRT) Aprepitant Cat’s claw (U. tomentosa) Levonorgestrel (implant) Bisacodyl Colecalciferol (Vitamin D3) Levonorgestrel (POP) Cimetidine Cyanocobalamin (B12) Cisapride Diosmin
Medroxyprogesterone (depot) Cyclizine Echinacea Medroxyprogesterone (oral) Dantron Eucalyptus globulus Medroxyprogesterone/ Domperidone Folic acid conjugated estrogens (HRT) Droperidol Garlic Medroxyprogesterone/ Esomeprazole Ginger (Z. officinale) estradiol (HRT) Famotidine Ginkgo biloba Norelgestromin/ethinylestradiol Granisetron Ginseng distribution. for (patch) Hyoscine Goldenseal (H. canadensis) Norethisterone Ispaghula husk Grape seed extract (Norethindrone) (depot Lactulose Grapefruit juice injection) Lansoprazole Green tea (C. sinensis) Norethisterone Linaclotide Homeopathic remedies (Norethindrone) (POP) Loperamide Inula racemosa Norethisterone Lubiprostone Iodine (Norethindrone)/estradiol Macrogol Iron supplements (HRT) Mebeverine Kava kava (P. methysticum)
Norethisterone distribution. for Not only. use ersonal Mesalazine Milk thistle (Norethindrone) Methylcellulose Retinol (Vitamin A) ethinylestradiol (COC) Metoclopramide Riboflavin (Vitamin B2) Norethisterone Naloxegol Serenoa repens (Norethindrone)/mestranol Omeprazole St John’s wort (COC) Ondansetron Thiamine (Vitamin B1) Norgestimate/ethinylestradiol Pantoprazole Turmeric (curcumin) (COC) Prucalopride Valerian Norgestrel/conjugated Rabeprazole Vitamin E estrogens (HRT) Ranitidine HIV Drugs
Norgestrel/ethinylestradiol Senna Not only. use For personal for distribution. Entry/Integrase Inhibitors (COC) Simeticone Bictegravir/FTC/TAF Sulfasalazine Erectile Dysfunction Agents Dolutegravir Trimebutine Sildenafil Dolutegravir/rilpivirine Tadalafil HCC Therapies Elvitegravir/cobi /FTC/TAF Vardenafil Pembrolizumab Elvitegravir/cobi/FTC/TDF Regorafenib Ibalizumab-uiyk Hepatitis Drugs Maraviroc Adefovir Raltegravir Daclatasvir NNRTIs Elbasvir/Grazoprevir Doravirine r personal use only. Not for distribution. For p for distribution. Not only. use r personal Glecaprevir/Pibrentasvir Doravirine/3TC/TDF Entecavir Efavirenz Lamivudine Etravirine Ledipasvir/Sofosbuvir Nevirapine OBV/PTV/r Rilpivirine OBV/PTV/r + Dasabuvir Rilpivirine/dolutegravir Peginterferon alfa-2a Rilpivirine/FTC/TAF
distribution. Fo distribution. Peginterferon alfa-2b NRTIs Ribavirin Abacavir Simeprevir Didanosine Sofosbuvir (SOF) Emtricitabine (FTC) SOF/Velpatasvir Emtricitabine + TAF SOF/Velpatasvir/Voxilaprevir Emtricitabine + TDF Telbivudine Lamivudine Tenofovir alafenamide (TAF) Stavudine Tenofovir-DF Tenofovir-DF Zidovudine Protease Inhibitors Atazanavir alone Atazanavir/cobicistat
For personal use only. Not for Not only. use For personal For personal use only. Not for distribution. For personal use only. Not Not only. use For personal for distribution. Not only. use For personal Atazanavir + ritonavir Darunavir/cobicistat Darunavir/cobi/FTC/TAF Darunavir + ritonavir Fosamprenavir Indinavir Lopinavir Ritonavir Saquinavir Tipranavir
Key to symbols Notes Further information is available at © Liverpool Drug Interactions Group, These drugs should not be coadministered www.hep-druginteractions.org University of Liverpool, Pharmacology Research Labs, Potential clinically significant interaction that is likely to require additional Predicted interactions are based on known 1st Floor Block H, 70 Pembroke Place, LIVERPOOL, L69 3GF monitoring, alteration of drug dosage or timing of administration metabolic pathways and routes of clearance. We aim to ensure that information is accurate and consistent with current knowledge Potential interaction likely to be of weak intensity. Additional Caution is required in patients with hepatic and practice. However, the University of Liverpool and its servants or agents shall action/monitoring or dosage adjustment is unlikely to be required impairment as this may also increase drug levels not be responsible or in any way liable for the continued currency of information in and require dose modification. this publication whether arising from negligence or otherwise howsoever or for any consequences arising therefrom. The University of Liverpool expressly exclude No clinically significant interaction expected Where advice differs between countries, the liability for errors, omissions or inaccuracies to the fullest extent permitted by law.
charts reflect the more cautious option.
www.hep-druginteractions.org
Interactions with PBC Agents
Charts created November 2020. Full information available at www.hep-druginteractions.org Page 4 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.
Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Acid Acid Acid Acid Acid Acid Hypertension/Heart Failure Agents Immunosuppressants Other Drugs Acebutolol Adalimumab Acamprosate Aliskiren Alemtuzumab Acetazolamide Ambrisentan Anakinra Acitretin Amiloride Azathioprine Activated charcoal Azilsartan Baricitinib Allopurinol Benazepril Basiliximab Atomoxetine Brodalumab Atropine
Bendroflumethiazide Baclofen Bosentan Ciclosporin Benralizumab Bumetanide Eculizumab Etanercept Betahistine Candesartan Fingolimod Bimatoprost Captopril Lenalidomide Biperiden Chlorothiazide Mycophenolate Brinzolamide Chlortalidone Bromocriptine Pirfenidone distribution. for Cilazapril Sirolimus Calcitonin Clevidipine Calcium carbimide Tacrolimus Clonidine Calcium resonium Lipid Lowering Agents Doxazosin Cannabidiol (CBD) Atorvastatin Enalapril Carbimazole Bezafibrate Carisoprodol Eplerenone Ezetimibe Epoprostenol Cilostazol Fenofibrate Clomifene Eprosartan Fish oils Colchicine Fosinopril ersonal use only. Not for distribution. for Not only. use ersonal Fluvastatin Colestyramine Furosemide Gemfibrozil Conivaptan Hydralazine Lovastatin Cyclobenzaprine Hydrochlorothiazide Pitavastatin Cytisine Iloprost Pravastatin Darbepoetin Indapamide Rosuvastatin Deferiprone Irbesartan Simvastatin Denosumab Isradipine Oxytocics Dexamfetamine Ivabradine Ergometrine (ergonovine) Dextromethorphan Lacidipine Mifepristone Disulfiram
Lercanidipine Misoprostol Not only. use For personal for distribution. Donepezil Lisinopril Parkinsonism Agents Dorzolamide Losartan Benztropine Dupilumab Macitentan Carbidopa Eliglustat Epoetin alfa Methyldopa Orphenadrine Etelcalcetide Metolazone Pramipexole Febuxostat Moxonidine Procyclidine Filgrastim Rasagiline Olmesartan Flibanserin Ropinirole Perindopril Gadopentetate (gadolinium) Prazosin PBC Agents Glycerol phenylbutyrate Quinapril For p for distribution. Not only. use r personal Obeticholic acid Goserelin Ramipril Ursodeoxycholic acid Influenza vaccine Ranolazine Steroids Isosorbide mononitrate Rilmenidine Beclometasone Isotretinoin Riociguat Betamethasone Lanreotide Selexipag Budesonide Levothyroxine Sildenafil Ciclesonide Lofexidine Clobetasol (topical) Spironolactone Fo distribution. Lumacaftor/Ivacaftor Clobetasone (topical) Tadalafil Magnesium Dexamethasone Melatonin Telmisartan Fludrocortisone Memantine Torasemide Flunisolide Methylphenidate Trandolapril Fluticasone Minoxidil Treprostinil Hydrocortisone (topical) Modafinil Valsartan Methylprednisolone Naftidrofuryl Xipamide Mometasone Nalmefene Zofenopril Prednicarbate Naloxone Illicit/Recreational Prednisone Naltrexone Alcohol Triamcinolone Neostigmine Amphetamine Urological Agents Nicorandil Cannabis Nusinersan For personal use only. Not for Not only. use For personal Alfuzosin Not only. use For personal for distribution. Not only. use For personal Ocrelizumab Carfentanil Desmopressin Orlistat Cocaine Dutasteride Penicillamine Ecstasy (MDMA) Finasteride Pentoxifylline GHB (Gamma-hydroxybutyrate) Mirabegron Phenylephrine Heroin Silodosin LSD (Lysergic acid Pilocarpine Solifenacin diethylamide) Piracetam Tamsulosin Mephedrone Potassium Tolterodine Methamphetamine Protamine sulphate Phencyclidine (PCP) Pseudoephedrine Pyridostigmine
Raloxifene Sevelamer Strontium ranelate Thalidomide Tranexamic acid Varenicline
Key to symbols Notes Further information is available at © Liverpool Drug Interactions Group, These drugs should not be coadministered www.hep-druginteractions.org University of Liverpool, Pharmacology Research Labs, Potential clinically significant interaction that is likely to require additional Predicted interactions are based on known 1st Floor Block H, 70 Pembroke Place, LIVERPOOL, L69 3GF monitoring, alteration of drug dosage or timing of administration metabolic pathways and routes of clearance. We aim to ensure that information is accurate and consistent with current knowledge Potential interaction likely to be of weak intensity. Additional Caution is required in patients with hepatic and practice. However, the University of Liverpool and its servants or agents shall action/monitoring or dosage adjustment is unlikely to be required impairment as this may also increase drug levels not be responsible or in any way liable for the continued currency of information in and require dose modification. this publication whether arising from negligence or otherwise howsoever or for any consequences arising therefrom. The University of Liverpool expressly exclude No clinically significant interaction expected Where advice differs between countries, the liability for errors, omissions or inaccuracies to the fullest extent permitted by law.
charts reflect the more cautious option.