www.hep-druginteractions.org Interactions with PBC Agents Charts created November 2020. Full information available at www.hep-druginteractions.org Page 1 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister. Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Acid Acid Acid Acid Acid Acid Anaesthetics & Muscle Relaxants Antibacterials (continued) Antidepressants Bupivacaine Cloxacillin Agomelatine Cisatracurium Dapsone Amitriptyline Isoflurane Delamanid Bupropion Ketamine Ertapenem Citalopram Nitrous oxide Erythromycin Clomipramine Propofol Ethambutol Desipramine Thiopental Flucloxacillin Desvenlafaxine Tizanidine Gentamicin Dosulepin Analgesics Imipenem Doxepin Aceclofenac Isoniazid Duloxetine Alfentanil Escitalopram Aspirin Levofloxacin Linezolid Fluoxetine Buprenorphine Lymecycline Fluvoxamine Celecoxib Imipramine Meropenem Codeine distribution. for Lithium Methenamine Dexketoprofen Maprotiline Metronidazole Dextropropoxyphene Mianserin Moxifloxacin Diamorphine Milnacipran Diclofenac Nitrofurantoin Mirtazapine Diflunisal Norfloxacin Moclobemide Dihydrocodeine Ofloxacin Nefazodone Etoricoxib Penicillin V Nortriptyline Fentanyl Piperacillin Paroxetine Flurbiprofen Pivmecillinam Sertraline Hydrocodone distribution. for only. Not use ersonal Pyrazinamide Tianeptine Hydromorphone Rifabutin Ibuprofen Trazodone Rifampicin Indometacin Trimipramine Rifapentine Ketoprofen Venlafaxine Mefenamic acid Rifaximin Vortioxetine Meloxicam Spectinomycin Antidiabetics Metamizole (Dipyrone) Streptomycin Acarbose Methadone Sulfadiazine Albiglutide Morphine Tazobactam Alogliptin Naproxen Telithromycin Canagliflozin Oxycodone Temocillin Not only. use For personal for distribution. Dapagliflozin Paracetamol Tetracyclines Dulaglutide Pethidine (Meperidine) Ticarcillin Empagliflozin Piroxicam Trimethoprim/Sulfamethoxazole Exenatide Tapentadol Troleandomycin Glibenclamide (Glyburide) Tramadol Vancomycin Gliclazide Anthelmintics Anticoagulant, Antiplatelet & Fibrinolytic Glimepiride Albendazole Acenocoumarol Glipizide Ivermectin Anagrelide Insulin Oxamniquine Apixaban Linagliptin Praziquantel Clopidogrel Liraglutide Pyrantel For p for distribution. Not only. use r personal Dabigatran Lixisenatide Antiarrhythmics Dalteparin Metformin Amiodarone Danaparoid Nateglinide Bepridil Dipyridamole Pioglitazone Digoxin Edoxaban Disopyramide Eltrombopag Repaglinide Dofetilide Enoxaparin Rosiglitazone Saxagliptin Dronedarone Fluindione Flecainide Fo distribution. Fondaparinux Sitagliptin Lidocaine (Lignocaine) Heparin Tolbutamide Mexiletine Phenprocoumon Vildagliptin Propafenone Prasugrel Antifungals Quinidine Rivaroxaban Amphotericin B Vernakalant Streptokinase Anidulafungin Antibacterials Ticagrelor Caspofungin Amikacin Ticlopidine Fluconazole Amoxicillin Tinzaparin Flucytosine Ampicillin Warfarin Griseofulvin Azithromycin Anticonvulsants Isavuconazole Aztreonam Carbamazepine Itraconazole Bedaquiline Clonazepam Ketoconazole Benzylpenicillin Eslicarbazepine For personal use only. Not for Not only. use For personal For personal use only. Not for distribution. For personal use only. Not Not only. use For personal for distribution. only. Not use For personal Miconazole Capreomycin Ethosuximide Nystatin Cefaclor Gabapentin Posaconazole Cefadroxil Lacosamide Cefalexin Lamotrigine Terbinafine Cefazolin Levetiracetam Voriconazole Cefixime Oxcarbazepine Cefotaxime Perampanel Cefradine Phenobarbital Ceftaroline Phenytoin Ceftazidime Pregabalin Ceftriaxone Primidone Cefuroxime Retigabine Chloramphenicol Rufinamide Ciprofloxacin Sultiame Clarithromycin Tiagabine Clavulanic acid Topiramate Clindamycin Valproate (Divalproex) Clofazimine Vigabatrin Zonisamide Key to symbols Notes Further information is available at © Liverpool Drug Interactions Group, These drugs should not be coadministered www.hep-druginteractions.org University of Liverpool, Pharmacology Research Labs, Potential clinically significant interaction that is likely to require additional Predicted interactions are based on known 1st Floor Block H, 70 Pembroke Place, LIVERPOOL, L69 3GF monitoring, alteration of drug dosage or timing of administration metabolic pathways and routes of clearance. We aim to ensure that information is accurate and consistent with current knowledge Potential interaction likely to be of weak intensity. Additional Caution is required in patients with hepatic and practice. However, the University of Liverpool and its servants or agents shall action/monitoring or dosage adjustment is unlikely to be required impairment as this may also increase drug levels not be responsible or in any way liable for the continued currency of information in and require dose modification. this publication whether arising from negligence or otherwise howsoever or for any consequences arising therefrom. The University of Liverpool expressly exclude No clinically significant interaction expected Where advice differs between countries, the liability for errors, omissions or inaccuracies to the fullest extent permitted by law. charts reflect the more cautious option. www.hep-druginteractions.org Interactions with PBC Agents Charts created November 2020. Full information available at www.hep-druginteractions.org Page 2 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister. Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Obeticholic Ursodeoxycholic Acid Acid Acid Acid Acid Acid Antihistamines Antivirals Cancer Therapies Astemizole Aciclovir Abiraterone Bilastine Amantadine Acalabrutinib Cetirizine Brivudine Anastrozole Chlorphenamine Cidofovir Avelumab Desloratadine Foscarnet Axitinib Diphenhydramine Oseltamivir Bevacizumab Doxylamine Blinatumomab Rimantadine Ebastine Valaciclovir Bortezomib Fexofenadine Zanamivir Bosutinib Hydroxyzine Brentuximab vedotin Anxiolytics/Hypnotics/Sedatives Levocetirizine Capecitabine Alprazolam Loratadine Carboplatin Amobarbital Promethazine Cetuximab Terfenadine Bromazepam for distribution. for Chlorambucil Antimigraine Agents Bromperidol Cisplatin Almotriptan Buspirone Cyclophosphamide Dihydroergotamine Clobazam Daratumumab Eletriptan Clorazepate Dasatinib Ergotamine Clotiapine Doxorubicin Frovatriptan Diazepam Erlotinib Methylergonovine Estazolam Estramustine Naratriptan Flurazepam Etoposide Pizotifen ersonal use only. Not for distribution. for only. Not use ersonal Lorazepam Everolimus Rizatriptan Lormetazepam Exemestane Sumatriptan Midazolam (oral) Fludarabine Zolmitriptan Midazolam (parenteral) Gefitinib Antiprotozoals Oxazepam Gemcitabine Amodiaquine Idarubicin Artemether Quazepam Imatinib Artemisinin Temazepam Ipilimumab Artesunate Triazolam Irinotecan Atovaquone Zaleplon Ixazomib Chloroquine Zolpidem for distribution. For personal use only. Not Not only. use For personal for distribution. Lapatinib Dihydroartemisinin Zopiclone Letrozole Doxycycline Beta Blockers Medroxyprogesterone Halofantrine Atenolol (oncology) Hydroxychloroquine Bisoprolol Mercaptopurine Lumefantrine Carvedilol Mesna Mefloquine Celiprolol Methotrexate Pentamidine Labetalol Primaquine Metoprolol Mitoxantrone Proguanil Nebivolol Nilotinib Pyrimethamine Oxprenolol Niraparib Quinine Nivolumab r personal use only. Not for distribution. For p for distribution. Not only. use r personal Pindolol Sodium stibogluconate Propranolol Obinutuzumab Sulfadoxine Sotalol Ofatumumab Antipsychotics/Neuroleptics Timolol Olaratumab Amisulpride Bisphosphonates Oxaliplatin Aripiprazole Alendronic acid Paclitaxel Panitumumab Asenapine Clodronate Chlorpromazine Pembrolizumab Ibandronic acid distribution. Fo distribution. Rituximab Chlorprothixene Pamidronate Clozapine Sorafenib Risedronate Flupentixol Sunitinib Fluphenazine Bronchodilators Tamoxifen Haloperidol Formoterol Temsirolimus Iloperidone Indacaterol Vinblastine Levomepromazine Ipratropium bromide Vincristine Lurasidone Montelukast Vinorelbine Omalizumab Olanzapine Contraceptives and Hormone Replacements Paliperidone Salbutamol Conjugated estrogens (HRT) Perazine Salmeterol Desogestrel (POP) Periciazine Theophylline Desogestrel/ethinylestradiol Perphenazine Tiotropium (COC) For personal use only. Not for Not only. use For personal Pimozide Not only. use For personal for distribution. only. Not use For personal Calcium Channel Blockers Dienogest Pipotiazine Amlodipine Drospirenone (POP) Prochlorperazine Diltiazem Quetiapine Drospirenone/estradiol Felodipine Risperidone (HRT) Nicardipine Drospirenone/estradiol Sulpiride Thioridazine Nifedipine (HRT) Nisoldipine Dydrogesterone/estradiol Tiapride Trifluoperazine Nitrendipine (HRT) Ziprasidone Verapamil Estradiol Zuclopentixol Ethinylestradiol Etonogestrel (implant) Etonogestrel (vaginal ring) Gestodene/ethinylestradiol (COC) Key