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Atlas Journal Atlas of Genetics and Cytogenetics in Oncology and Haematology Home Genes Leukemias Solid Tumours Cancer-Prone Deep Insight Portal Teaching X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA Atlas Journal Atlas Journal versus Atlas Database: the accumulation of the issues of the Journal constitutes the body of the Database/Text-Book. TABLE OF CONTENTS Volume 12, Number 6, Nov-Dec 2008 Previous Issue / Next Issue Genes BCL8 (B-cell CLL/lymphoma 8) (15q11). Silvia Rasi, Gianluca Gaidano. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 781-784. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/BCL8ID781ch15q11.html CDC25A (Cell division cycle 25A) (3p21). Dipankar Ray, Hiroaki Kiyokawa. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 785-791. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/CDC25AID40004ch3p21.html CDC73 (cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)) (1q31.2). Leslie Farber, Bin Tean Teh. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 792-797. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/CDC73D181ch1q31.html EIF3C (eukaryotic translation initiation factor 3, subunit C) (16p11.2). Daniel R Scoles. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 798-802. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/EIF3CID44187ch16p11.html ELAC2 (elaC homolog 2 (E. coli)) (17p11.2). Yang Chen, Sean Tavtigian, Donna Shattuck. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 803-806. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/ELAC2ID40437ch17p11.html FOXM1 (forkhead box M1) (12p13). Jamila Laoukili, Monica Alvarez Fernandez, René H Medema. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 807-813. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/FOXM1ID40631ch12p13.html PTCH2 (patched homolog 2 (Drosophila)) (1p34.1). Peter Zaphiropoulos. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 814-820. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/PTCH2ID41892ch1p34.html PTPN21 (protein tyrosine phosphatase, non-receptor type 21) (14q31.3). Antonio Feliciello. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 821-824. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/PTPN21ID41916ch14q21.html S100A13 (S100 calcium binding protein A13) (1q21.3). Atlas Genet Cytogenet Oncol Haematol 2008; 6 I Carlo Barone, Cinzia Bagalà, Matteo Landriscina. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 825-830. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/S100A13ID44197ch1q21.html TACSTD1 (tumor-associated calcium signal transducer 1) (2p21). Olivier Gires. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 831-836. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/TACSTD1ID42459ch2p21.html TNC (tenascin C (hexabrachion)) (9q33.1). Martin Degen, Ruth Chiquet-Ehrismann. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 837-842. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/TNCID42597ch9q33.html TNN (tenascin N) (1q25.1). Martin Degen, Ruth Chiquet-Ehrismann. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 843-847. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/TNNID44209ch1q25.html VTCN1 (V-set domain containing T cell activation inhibitor 1) (1p13.1). Panduka Samarawardana, Kenneth R Shroyer. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 848-853. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/VTCN1ID44144ch1p13.html Leukaemias t(8;12)(q24;q22). Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 854-855. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Anomalies/t0812q24q22ID2057.html t(7;21)(p22;q22). Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 856-857. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Anomalies/t0721p22q22ID1449.html t(6;11)(q13;q23). Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 858-859. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Anomalies/t0611q13q23ID1408.html inv(11)(p15q22). Cristina Morerio, Claudio Panarello. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 860-862. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Anomalies/inv11p15q22ID1116.html t(4;11)(q35;q23). Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 863-864. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Anomalies/t0411q35q23ID1423.html t(3;8)(q26;q24). Pei Lin. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 865-867. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Anomalies/t0308q26q24ID1463.html t(1;9)(q24;q34). Etienne De Braekeleer, Marc De Braekeleer. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 868-871. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Anomalies/t0109q24q34ID2109.html t(12;13)(p13;q14). Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 872-874. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Anomalies/t1213p13q14ID1323.html Solid Tumours Atlas Genet Cytogenet Oncol Haematol 2008; 6 II Thyroid: Anaplastic (undifferentiated) carcinoma - updated. Sai-Ching Jim Yeung. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 875-880. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Tumors/AnaCarciThyroidID5069.html Cancer Prone Diseases Cartilage-hair hypoplasia (CHH). Pia Hermanns, Brendan Lee. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 881-887. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Kprones/CartilageHairHypoID10105.html Deep Insights Case Reports A case of trisomy 8 and loss of the Y-chromosome as secondary aberrations in a ten year old boy with de novo AML FAB M2 and t(16;21)(q24;q22). Jutta Bradtke, Peter Vorwerk, Jochen Harbott. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 888-891. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Reports/1621BradtkeID100031.html Educational Items Evolution. Robert Kalmes. Atlas Genet Cytogenet Oncol Haematol 2008; 12 (6): 892-895. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Educ/EvolutionID30026ES.html © Atlas of Genetics and Cytogenetics in Oncology and Haematology X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA Home Genes Leukemias Solid Tumours Cancer-Prone Deep Insight Portal Teaching For comments and suggestions or contributions, please contact us [email protected]. Atlas Genet Cytogenet Oncol Haematol 2008; 6 III Atlas of Genetics and Cytogenetics in Oncology and Haematology BCL8 (B-cell CLL/lymphoma 8) Identity Other names BCL8A HGNC BCL8 Location 15q11 Location_base_pair Starts at 19130067 and ends at 19159209 bp from pter ( according to hg18- Mar_2006). DNA/RNA Description Gene of 86686 bp with 3 exons(1bp-222bp/84886bp-85041bp/86517bp-86686bp). The 5' part of exon 1 and the 3' part of exon 3 are non coding. Transcription Two alternative transcripts: a major transcript of 2.6Kb and a less expressed transcript of 4.5Kb, due to differential polyadenylation. Coding sequence: CDS 208-510. The direction of transcription is from telomere to centromere. Pseudogene Identified a family of evolutionarily conserved human genes with extensive homology to BCL8; these genes are BCL8B (chr.13), BCL8C (chr.22), BCL8D (chr.2), and BCL8E (chr.10). BCL8B is the most complete gene, whereas the other genes are truncated, can yield only sterile transcripts, and thus are probably pseudogenes. Protein Description 100 amino acids, predicted molecular weight of 19 kDa; predicted: similar to protein neurobeachin (Lysosomal trafficking regulator 2). Expression mRNA predominantly expressed in testis and prostate, with no transcripts normally found in hematopoietic tissues. Its expression in lymphoid tissues can be activated by chromosomal translocation or by other mechanisms in diffuse large B-cell lymphoma (DLBCL) patients. BCL8 expression was detected in all patients with 15q11-13 abnormalities and in a significant proportion of DLBCL patients. Function Probably produced truncated polypeptides with uncertain function. Homology Interspecies: homolog to N-terminal of Caenorhabditis elegans F10.f2.1 (59% homology) and to N-terminal of Drosophila melanogaster protein kinase A (PKA) anchoring protein RG (67% homology). Implicated in Entity t(14;15)(q32;q11) --> IghV - BCL8 Note Possibly other translocations of BCL8 involve other sites such as 22q11, 9p13, 1p32, 7p13, 12q24, and 15q22. Disease Translocations affecting BCL8 gene and various partners occur in about 4% of diffuse large B-cell lymphoma (DLBCL). Translocations involving the chromosomal region 15q11-13 have also been identified in non lymphoid tumors. Prognosis The effect of BCL8 expression on the prognosis of patients has yet to be investigated. Hybrid/Mutated The chromosomal translocation does not led to the formation of a hybrid gene. Gene Oncogenesis Chromosomal translocation in DLBCL causes activation of the BCL8 proto-oncogene by deregulated expression of BCL8. Breakpoints Atlas Genet Cytogenet Oncol Haematol 2008; 6 781 External links Nomenclature HGNC BCL8 1007 Entrez_Gene BCL8 606 B-cell CLL/lymphoma 8 Cards Atlas BCL8ID781ch15q11 GeneCards BCL8 Ensembl ENSG00000110987 [Gene_View] BCL8 [Vega] Genatlas BCL8 Genomic and cartography BCL8 - 15q11 chr15:19130067-19159209 - 15q11-q13 [Description] (hg18- GoldenPath Mar_2006) Ensembl BCL8 - 15q11-q13 [CytoView] NCBI Mapview OMIM 601889 Disease map [OMIM] HomoloGene BCL8 Gene and transcription Genbank AL832227 [ ENTREZ ] Genbank DA278599 [ ENTREZ ] RefSeq NC_000015
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