SOCS7 Antibody Cat. No.: 58-953

SOCS7 Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

HOMOLOGY: Predicted species reactivity based on immunogen sequence: Mouse

This SOCS7 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 458-486 amino acids from the C-terminal region of human SOCS7.

TESTED APPLICATIONS: WB

APPLICATIONS: For WB starting dilution is: 1:1000

PREDICTED MOLECULAR 63 kDa WEIGHT:

Properties

This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification.

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

October 2, 2021 1 https://www.prosci-inc.com/socs7-antibody-58-953.html CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: SOCS7

Suppressor of cytokine signaling 7, SOCS-7, Nck, Ash and phospholipase C gamma-binding ALTERNATE NAMES: protein, Nck-associated protein 4, NAP-4, SOCS7, NAP4, SOCS6

ACCESSION NO.: O14512

GENE ID: 30837

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth BACKGROUND: hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

REFERENCES: 1) Pazienza, V., et al. J. Gen. Virol. 91 (PT 7), 1678-1686 (2010) :

2) Sasi, W., et al. BMC Cancer 10, 178 (2010) :

3) Kremer, B.E., et al. Cell 130(5):837-850(2007)

4) Zody, M.C., et al. Nature 440(7087):1045-1049(2006)

ANTIBODIES FOR RESEARCH USE ONLY.

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