SOCS7 Antibody Cat. No.: 58-953 SOCS7 Antibody Specifications HOST SPECIES: Rabbit SPECIES REACTIVITY: Human HOMOLOGY: Predicted species reactivity based on immunogen sequence: Mouse This SOCS7 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 458-486 amino acids from the C-terminal region of human SOCS7. TESTED APPLICATIONS: WB APPLICATIONS: For WB starting dilution is: 1:1000 PREDICTED MOLECULAR 63 kDa WEIGHT: Properties This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification. CLONALITY: Polyclonal ISOTYPE: Rabbit Ig October 2, 2021 1 https://www.prosci-inc.com/socs7-antibody-58-953.html CONJUGATE: Unconjugated PHYSICAL STATE: Liquid BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide. CONCENTRATION: batch dependent Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. Additional Info OFFICIAL SYMBOL: SOCS7 Suppressor of cytokine signaling 7, SOCS-7, Nck, Ash and phospholipase C gamma-binding ALTERNATE NAMES: protein, Nck-associated protein 4, NAP-4, SOCS7, NAP4, SOCS6 ACCESSION NO.: O14512 GENE ID: 30837 USER NOTE: Optimal dilutions for each application to be determined by the researcher. Background and References Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth BACKGROUND: hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). REFERENCES: 1) Pazienza, V., et al. J. Gen. Virol. 91 (PT 7), 1678-1686 (2010) : 2) Sasi, W., et al. BMC Cancer 10, 178 (2010) : 3) Kremer, B.E., et al. Cell 130(5):837-850(2007) 4) Zody, M.C., et al. Nature 440(7087):1045-1049(2006) ANTIBODIES FOR RESEARCH USE ONLY. For additional information, visit ProSci's Terms & Conditions Page. October 2, 2021 2 https://www.prosci-inc.com/socs7-antibody-58-953.html.