New Cytotoxic Pregnane-Type Steroid from the Stem Bark of Aglaia Elliptica (Meliaceae)
ORIGINAL ARTICLE Rec. Nat. Prod. 12:2 (2018) 121-127 New Cytotoxic Pregnane-type Steroid from the Stem Bark of Aglaia elliptica (Meliaceae) Kindi Farabi 1, Desi Harneti 1, Nurlelasari 1, Rani Maharani 1, Ace Tatang Hidayat 1,2, Khalijah Awang 3, Unang Supratman 1,2,* and Yoshihito Shiono 4 1Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia 2Central Laboratory of Universitas Padjadjaran, Jatinangor 45363, Sumdeang, Indonesia 3Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 59100, Malaysia 4Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan (Received July 5, 2017; Revised September 13, 2017; Accepted September 13, 2017) Abstract: A new pregnane-type steroid, 2α-hydroxy-3α-methoxy-5α-pregnane (1), together with three known dammarane-type triterpenoid, 3β-acetyl-20S,24S-epoxy-25-hydroxydammarane (2), 20S,24S-epoxy-3α,25- dihydroxydammarane (3), and eichlerianic acid (4) have been isolated from the stem bark of Aglaia elliptica. The structures were determined by spectroscopic methods including the 2D-NMR techniques. Compound 1-4 showed moderate cytotoxic activity against P-388 murine leukemia cells. Keywords: Pregnane-type steroid; Aglaia elliptica; cytotoxic activity; Meliaceae. © 2018 ACG Publications. All rights reserved. 1. Introduction Aglaia is the largest genus belong to Meliaceae family contain about 150 species, and more than 65 species of them were grown in Indonesia [1,2]. Recently, Aglaia genus used traditionally for treatment some desease. In Thailand, A. odorata used for the treatment of traumatic injury, bruises, febrifuge, heart disease and toxin by causing vomiting [3] and the bark of A.
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