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15Th International Symposium on Bioinformatics Research and Applications ISBRA 2019 15th International Symposium on Bioinformatics Research and Applications June 3–6, 2019 Technical University of Catalonia Barcelona, Spain http://alan.cs.gsu.edu/isbra19/ About the Technical University of Catalonia The Technical University of Catalonia (UPC) is a public institution of Higher Education and Research, specialized in the areas of Architecture, Engineering, Science and Technology. The UPC has a wide spread presence in Catalonia, with nine campuses located in Barcelona and nearby towns. The campuses are accessible, well connected by public transport and equipped with the necessary facilities and services to contribute to learning, research and university life. Founded in 1968 by grouping together existing state technical schools of Architecture and Engineering in Barcelona, which date back from the mid-19th century, it gained university status in 1971. The UPC today has a student population of over 30,000, with more than 3,000 teaching and research staff and about 2,000 administrative and service staff. There are 64 bachelor’s degrees, 68 master’s degrees, and 46 doctoral programs offered by 20 schools. Further, there are 50 international double-degree agreements with 30 universities, and about 3,000 students in international mobility programs. Research teams generate e60 million in annual funding, with a total budget of about e300 million. About the Department of Computer Science The Department of Computer Science was created in 1987 and is one of the largest depart- ments at the UPC. It has about 90 full-time faculty and 50 Ph.D. students. The Department is responsible for teaching and research in several disciplines related to the foundations of computing and their applications. The core of the teaching activities is concentrated in the undergraduate and master’s programs of the Barcelona School of Informatics, but the Department is also teaching at several other UPC schools. The Department is coordinating two Ph.D. programs: Computing and Artificial Intelligence. The research activities of the Department are organized in different research groups, covering various Computer Science disciplines. It has an active presence in the main conferences of the field and an intense participation in public and industrial projects, as well as in the creation of spin-off companies. Message from the General Chairs We are delighted to welcome you to the 15th International Symposium on Bioinformatics Research and Applications (ISBRA 2019) being held on the campus of Technical University of Catalonia in Barcelona. We are honored to serve the international community by bringing together scholars, scientists, and students from academia, laboratories, and industry to this premier meeting. We would like to thank Program Chairs Zhipeng Cai, Pavel Skums, and Min Li for putting together a terrific technical program. We thank the program committee and reviewers for their hard work, and also thank all authors who submitted papers and abstracts for their contribu- tions. We believe that you will enjoy all contributed and keynote talks this week! We are grateful to M´ıriam Hernandez´ and Ana Iba´nez˜ from the Technical University of Cat- alonia for help in coordinating ISBRA 2019. We also thank the Publications Chairs Olga Glebova, Mingon Kang, and Fa Zhang and Webmasters Filipp Rondel and Sergey Knyazev for their efforts in publicizing the symposium. We would like to recognize Technical University of Catalonia for hosting ISBRA 2019. We would like to thank Carme Casas and Xavier Masso´ for their help in making these venues available for symposium presentations and on-campus housing of participants. Last but not least, we would like to thank our sponsors: the National Science Foundation, the Department of Computer Science of the Technical University of Catalonia, and the Department of Com- puter Science of Georgia State University. Thanks to their generous support we have been able to award travel fellowships to graduate students and post-doctoral scholars from USA and abroad. We hope you will have a wonderful time at the symposium and enjoy the beautiful Barcelona. Gabriel Valiente, Technical University of Barcelona, Spain Alexander Zelikovsky, Georgia State University, USA Message from the Program Chairs On behalf of the Program Committee, we would like to welcome you to the proceedings of the 15th edition of the International Symposium on Bioinformatics Research and Applica- tions (ISBRA 2019), held in Barcelona, Spain, June 3–6, 2019. The symposium provides a forum for the exchange of ideas and results among researchers, developers, and practitioners working on all aspects of bioinformatics and computational biology and their applications. This year we received 95 submissions in response to the call for extended abstracts. The Pro- gram Committee decided to accept 22 of them for full publication in the proceedings and oral presentation at the symposium. We also accepted 23 for oral presentation. Furthermore, we received 20 submissions in response to the call for short abstracts. The technical program invited keynote talks were given by Prof. Niko Beerenwinkel from ETH Zurich,¨ Prof. Roderic Guigo´ from the Centre for Genomic Regulation, and Prof. Mar- tin Vingron from the Max Planck Institute for Molecular Genetics. We would like to thank the Program Committee members and the additional reviewers for volunteering their time to review and discuss symposium papers. We would like to extend special thanks to the Steer- ing and General Chairs of the symposium for their leadership, and to the Publicity and Local Chairs for their hard work in making ISBRA 2019 a successful event. Last but not least, we would like to thank all authors for presenting their work at the symposium. Zhipeng Cai, Georgia State University Pavel Skums, Georgia State University Min Li, Central South University Keynote Speakers Niko Beerenwinkel Associate Professor, Computational Biology, ETH Zurich Roderic Guigo´ Director, Bioinformatics Program, Centre for Genomic Regulation, Barcelona Martin Vingron Director, Max Planck Institute for Molecular Genetics, Head of Computational Molecular Biology Department Symposium Organizers Steering Committee Yi Pan (Georgia State University, USA), Chair Dan Gusfield (University of California, Davis, USA) Ion Mandoiu (University of Connecticut, USA) Marie-France Sagot (INRIA, France) Ying Xu (University of Georgia, USA) Aidong Zhang (University of Virginia, USA) General Chairs Gabriel Valiente (Technical University of Catalonia, Spain) Alexander Zelikovsky (Georgia State University, USA) Local Chair Gabriel Valiente (Technical University of Catalonia, Spain) Program Chairs Zhipeng Cai (Georgia State University, USA) Pavel Skums (Georgia State University, USA) Min Li (Central South University, China) Publicity Chairs Olga Glebova (Georgia State University, USA) Mingon Kang (Kennesaw State University, USA) Fa Zhang (Chinese Academy of Science, China) Webmasters Filipp Rondel (Georgia State University, USA) Sergey Knyazev (Georgia State University, USA) Program Committee Members Kamal Al Nasr (Tennessee State University) Fenglou Mao (National Institute of Health) Max Alekseyev (George Washington Univer- Yuri Orlovich (Belarusian State Univ.) sity) Andrei Paun (University of Bucharest) Nikita Alexeev (ITMO University) Nadia Pisanti (Universita di Pisa) Mukul S. Bansal (University of Connecticut) Yuri Porozov (ITMO University) Paola Bonizzoni (Universita di Milano- Russell Schwartz (Carnegie Mellon Univer- Bicocca) sity) Zhipeng Cai (Georgia State University) Joao Setubal (University of Sao Paulo) Hongmin Cai (South China University of Yi Shi (Shanghai Jiaotong University) Technology) Xinghua Shi (University of North Carolina at Xing Chen (Chinese Academy of Sciences) Charlotte) Xuefeng Cui (Tsinghua University) Dong Si (University of Washington) Ovidiu Daescu (Univ. of Texas at Dallas) Pavel Skums (Georgia State University) Lei Deng (Central South University) Ileana Streinu (University of Massachusetts Pufeng Du (Tianjin University) Amherst) Oliver Eulenstein (Iowa State University) Emily Su (Taipei Medical University) Xin Gao (King Abdullah University of Sci- Shiwei Sun (Chinese Academy of Sciences) ence and Technology) Sing-Hoi Sze (Texas A&M University) Xuan Guo (University of North Texas) Weitian Tong (Georgia Southern University) Olga Glebova (Georgia State University) Gabriel Valiente (Technical University of Cat- Zengyou He (Dalian University of Technol- alonia) ogy) Jianxin Wang (Central South University) Steffen Heber (North Carolina State Univ.) Li-San Wang (University of Pennsylvania) Jinling Huang (East Carolina University) Guohua Wang (Harbin Institute of Technol- Mingon Kang (Kennesaw State University) ogy) Wooyoung Kim (University of Washington) Seth Weinberg (Virginia Commonwealth Uni- Danny Krizanc (Wesleyan University) versity) Xiujuan Lei (Shaanxi Normal University) Yubao Wu (Georgia State University) Shuai-Cheng Li (City University of Hong Fangxiang Wu (University of Saskatchewan) Kong) Yufeng Wu (University of Connecticut) Yaohang Li (Old Dominion University) Zeng Xiangxiang (Xiamen University) Jing Li (Case Western Reserve University) Guoxian Yu (Southwest University) Min Li (Central South University) Ning Yu (Georgia State University) Xiaowen Liu (Indiana University) Alex Zelikovsky (Georgia State University) Bingqiang Liu (Shandong University) Le Zhang (Southwest University) Ion Mandoiu (University of Connecticut) Xuegong Zhang (Tsinghua University) Igor Mandric (University of California, Los Xing-Ming
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