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Research Report 2006 Max Planck Institute for Molecular Genetics, Berlin Imprint | Research Report 2006 MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS Research Report 2006 Max Planck Institute for Molecular Genetics, Berlin Imprint | Research Report 2006 Published by the Max Planck Institute for Molecular Genetics (MPIMG), Berlin, Germany, August 2006 Editorial Board Bernhard Herrmann, Hans Lehrach, H.-Hilger Ropers, Martin Vingron Coordination Claudia Falter, Ingrid Stark Design & Production UNICOM Werbeagentur GmbH, Berlin Number of copies: 1,500 Photos Katrin Ullrich, MPIMG; David Ausserhofer Contact Max Planck Institute for Molecular Genetics Ihnestr. 63–73 14195 Berlin, Germany Phone: +49 (0)30-8413 - 0 Fax: +49 (0)30-8413 - 1207 Email: [email protected] For further information about the MPIMG please see our website: www.molgen.mpg.de MPI for Molecular Genetics Research Report 2006 Table of Contents The Max Planck Institute for Molecular Genetics . 4 • Organisational Structure. 4 • MPIMG – Mission, Development of the Institute, Research Concept. .5 Department of Developmental Genetics (Bernhard Herrmann) . 7 • Transmission ratio distortion (Hermann Bauer) . .11 • Signal Transduction in Embryogenesis and Tumor Progression (Markus Morkel). 14 • Development of Endodermal Organs (Heiner Schrewe) . 16 • Gene Expression and 3D-Reconstruction (Ralf Spörle). 18 • Somitogenesis (Lars Wittler). 21 Department of Vertebrate Genomics (Hans Lehrach) . 25 • Molecular Embryology and Aging (James Adjaye). .31 • Protein Expression and Protein Structure (Konrad Büssow). .34 • Mass Spectrometry (Johan Gobom). 37 • Bioinformatics (Ralf Herwig). .40 • Comparative and Functional Genomics (Heinz Himmelbauer). 44 • Genetic Variation (Margret Hoehe). 48 • Cell Arrays/Oligofingerprinting (Michal Janitz). .52 • Kinetic Modeling (Edda Klipp) . .56 • In Vitro Ligand Screening (Zoltán Konthur). .60 • Neurodegenerative Disorders (Sylvia Krobitsch). .64 • Protein Complexes & Cell Organelle Assembly/ USN (Bodo Lange/Thorsten Mielke). .67 • Automation & Technology Development (Hans Lehrach). .70 • Evolution and Development (Georgia Panopoulou/Albert Poustka). 74 • Cardiovascular Genetics (Silke Sperling). 78 • Chromosome 21, Gene Expression and Regulation (Marie-Laure Yaspo). 81 • Associated Group – Gene Traps and Microarrays – Molecular Analysis of Heart Failure (Patricia Ruiz). 85 Department of Human Molecular Genetics (H .-Hilger Ropers) . 88 • Signal Transduction in Mental Retardation and Pain (Tim Hucho). .92 • Chromosome Rearrangements and Disease (Vera Kalscheuer). .94 • Familial Cognitive Disorders (Andreas Kuß). 97 • Neurobiology (Constance Scharff). .99 • Clinical Genetics and Biochemistry (Susann Schweiger) . .103 • Clinical Genetics (Andreas Tzschach). .106 • Molecular Cytogentics (Reinhard Ullmann). 109 • Neurochemistry Group & Mouse Lab (Diego J. Walter). 112 • Associated Group – Molecular Cytology (Harry Scherthan). 114 Department of Computational Molecular Biology (Martin Vingron) . 117 • Evolutionary Genomics (Peter Arndt). .119 • Gene Structure and Array Design (Stefan Haas). 121 • Microbial Virulence (Roland Krause). 123 • Algorithmics (Alexander Schliep). .125 • Computational Diagnostics (Rainer Spang) . 128 • Transcriptional Regulation (Martin Vingron). .131 • Protein Families and Evolution (Eike Staub). .135 The Max Planck Institute for Molecular Genetics MPI for Molecular Genetics Research Report 2006 Research Group Development & Disease (Stefan Mundlos) . 137 Ribosome Groups . 144 • Ribosome crystallography (Paola Fucini). .144 • Translation, Structure and Functions of Ribosomes (Knud Nierhaus). 147 Otto Warburg Laboratory . 149 • Bioinformatics / Structural Proteomics (Michael Lappe) . .149 Miscellaneous Research Groups . 152 • Microscopy (Rudi Lurz). 152 • High throughput technology group (htpt) (Richard Reinhardt). .155 Research Support & Central Units . 159 • Histology Unit. .159 • Service Group Analytics and IT. 160 • Animal Facility & Transgene Unit. 162 • Library. .164 • Service Group Imaging . .165 • Administration and Research Support. .166 • Technical Management and Workshops. .168 How to get to the Institute . 169 T he MaxPlanckInstitutefor Molecular Genetics O Dept. Martin Vingron Dept. H.-Hilger Ropers Dept. Hans Lehrach Dept. Bernhard Herrmann Research Group Stefan Mundlos rganisational Computational Molecular Biology Human Molecular Genetics Vertebrate Genomics Managing Director Developmental Genetics Development & Disease Tim Hucho James Adjaye Peter Arndt Hermann Bauer Molecular pathways in mental retardation and pain Molecular Embryology and Aging Evolutionary Genomics Transmission ratio distortion Vera Kalscheuer Konrad Büssow Stefan Haas Markus Morkel Chromosome rearrangement & disease Protein Structure Factory Gene structure & array design Signal Transduction in Embryogenesis & Tumor Progression Andreas Kuß Johan Gobom Roland Krause Familial mental retardation Mass spectrometry Microbial Virulence Heiner Schrewe (joint group with the MPI for Infection Biology) Development of endodermal organs Constance Scharff Ralf Herwig Neurobiology of bird song and speech development Bioinformatics Alexander Schliep Ralf Spörle Algorithms Expression analysis & D imaging S Susann Schweiger Heinz Himmelbauer Institute of Medical Genetics, Biochemistry of inherited brain disorders Comparative and Functional Genomics Rainer Spang Lars Wittler Charité, University Medicine Berlin tructure Computational diagnostics Somitogenesis Stefan Mundlos Andreas Tzschach Margret Hoehe Clinical genetics Genetic variation, haplotypes & genetics of complex Martin Vingron diseases Transcriptional regulation Reinhard Ullmann Molecular cytogenetics Michal Janitz Institute of Genetics, Oligofingerprinting / cell arrays Charité, University Medicine Berlin Diego J . Walther Bernhard Herrmann Serotonin metabolism and disease; Mouse lab Edda Klipp Kinetic modeling Zoltán Konthur In vitro ligand screening Sylvia Krobitsch Neurodegenerative disorders Administration / Bodo Lange, Thorsten Mielke Rudi Lurz Protein complexes & cell organelle assembly/ USN Microscopy Otto Warburg Laboratory Research Support Ribosome Group (Independent Junior Research Groups) Manuela B. Urban / Martin Vingron Hans Lehrach Richard Reinhardt Automation & Technology Development High-throughput technologies Manuela Urban Richard Reinhardt Paola Fucini Michael Lappe Administration Analytics Georgia Panopoulou / Albert Poustka Ribosome Crystallography Bioinformatics Evolution & development Ulf Bornemann Ludger Hartmann Knud H . Nierhaus Technical Manage- Animal Facility / Silke Sperling Ribosomal function ment & Workshops Transgene Unit Cardiovascular genetics Library Bernhard Herrmann Marie-Laure Yaspo Stem-cell Facility Human chromosome Rudi Lurz Imaging Stefan Mundlos Histology Representative of the scientific staff at the Biology Official women‘s representative Workscouncil Richard Reinhardt and Medicine Section Melanie Wendehack Chairman: Klaus von Knoblauch Computing Stefan Haas MPI for Molecular Genetics Research Report 2006 The Max Planck Institute for Molecular Genetics Mission Research at the Max Planck Institute for Molecular Genetics (MPIMG) concentrates on genome analysis of humans and other organisms to elucidate cellular processes and genetic diseases. It is the overall goal of the combined efforts of all MPIMG groups to gain new insights into the development of diseases on a molecular level, thus contributing to the development of cause-related new medical treatments. Development of the Institute The Max Planck Institute for Molecular Genetics (MPIMG) was founded in 1964 with the appointment of Heinz-Günther Wittmann and Heinz Schuster as heads of department, followed by the appointment of Thomas Trautner in 1965. At this time, the research of the institute was focussing on DNA replication and gene regulation in bacteria, bacterial phage and fungi (departments Schuster and Trautner) and on the structure, function and evolution of ribosomes which were central to the work of H.-G. Wittmann. In 1970, the three de- partments, as well as four independent junior research groups (the future Otto Warburg Laboratories) moved into the new premises of the institute situated in the Ihnestraße, Berlin-Dahlem. After the sudden death of H.-G. Wittmann in 1990 and the retirement of H. Schuster in 1995, the appointments of Hans Lehrach (1994, Dept. of Vertebrate Genomics), and Hans-Hilger Ropers (Dept. of Human Molecular Genetics, full-time since 1997) induced a major shift in the scientific orientation of the institute. Following the retirement of T. Trautner in 2000, Martin Vingron was appointed as head of the new Department for Computational Molecular Biology. At the same time, Stefan Mundlos was jointly appointed by the Humboldt University of Berlin and the Max Planck Society as head of the Institute for Medical Genetics and of an independent research group at the MPIMG. Together with the Free University of Berlin, Bernhard Herrmann has been appointed professor at the university and director at the institute in 2003, forming the fourth departement. In 2004 a new independent junior research group in Bioinformatics took up its work. The Max Planck Institute for Molecular Genetics Research Concept Genome research, the systematic study of genes and genomes, has changed the way in which research in mo- lecular genetics is pursued. The focus and composition of the MPI for Molecular Genetics reflects this devel- opment. Large scale genome research (Dept. Lehrach) applying a variety of technologies supplies us with the technology and the data on genome sequences, genes, and their
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