DOCSLIB.ORG

(12) Patent Application Publication (10) Pub. No.: US 2014/0227686 A1 Saghbini Et Al

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
(12) Patent Application Publication (10) Pub. No.: US 2014/0227686 A1 Saghbini Et Al US 20140227686A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2014/0227686 A1 Saghbini et al. (43) Pub. Date: Aug. 14, 2014 (54) STABILIZED CHEMICAL DEHYDRATION OF Publication Classification BOLOGICAL MATERAL (51) Int. Cl. (71) Applicant: GENTEGRALLC, Pleasanton, CA CI2O I/68 (2006.01) (US) (52) U.S. Cl. CPC .................................... CI2O I/6806 (2013.01) (72) Inventors: Michael Saghbini, Poway, CA (US); USPC ........................................................... 435/6.1 Michael Hogan, Tucson, AZ (US); Chunnian Shi, San Diego, CA (US); (57) ABSTRACT Brian Dalby, Carlsbad, CA (US); David Wong, San Marcos, CA (US) The present invention provides compositions and methods that enable the stabilization and storage of samples by con (73) Assignee: GENTEGRALLC, Pleasanton, CA tacting a sample with an assembly of particles, and reducing (US) the water activity level of the contacted sample. By reducing the water activity level of the sample, the assembly of par (21) Appl. No.: 14/254,478 ticles minimizes the degradation of the sample. Stabilizers may or may not be added to the assembly of particles to (22) Filed: Apr. 16, 2014 further minimize the degradation of the sample. Subsequently to storage in the assembly of particles, the samples are recov Related U.S. Application Data erable by eluting the assembly of particles with a fluid solu tion. In one embodiment, the entire assembly of particles will (63) y apps No. 13/081,436, filed on dissolve into the solution. In another embodiment, only part pr. o. s of the assembly of particles will dissolve into the solution. (60) Provisional application No. 61/321,269, filed on Apr. The assembly of particles provides the advantage that while it 6, 2010. is porous, it comprises non-porous particulate material. Patent Application Publication Aug. 14, 2014 Sheet 1 of 4 US 2014/022768.6 A1 FIGURE 1: Fig. 1.1 Biolodicalinioniral fluid &- Close & id Fig. 1.2 water soluble crystalline compoundstabilizers it Solid tissue s Š Closeid is Swabbed l Close biological material id FIGURE 2: Biaiogist Fisic: S & assa:&ssiss&s Rs 3&s &&ssssssss & s&sassissississirees 88sixxx 888 & 388xxiiise & six & &SS &SSSS Patent Application Publication Aug. 14, 2014 Sheet 2 of 4 US 2014/022768.6 A1 FIGURE3 &sess &: Rsriko. Sigtskarsge::cess. Six. FIGURE 4: Patent Application Publication Aug. 14, 2014 Sheet 3 of 4 US 2014/022768.6 A1 FIGURES: X S. S SS S Š SS S Sucrose Saliva Cotton tipped swabs Polyester tipped swabs Collection FIGURE 6: US $3. Šs 338. E3:Sf 8: S&S Risis: &S ESE issisp. Šssis Patent Application Publication Aug. 14, 2014 Sheet 4 of 4 US 2014/022768.6 A1 FG US 2014/022768.6 A1 Aug. 14, 2014 STABILIZED CHEMICAL DEHYDRATION OF tions from biological samples, including DNA, RNA, BOLOGICAL MATERAL polypeptides, viral samples, cell extracts, antibodies, and cell cultures. The invention further provides methods for stabiliz CROSS-REFERENCE TO RELATED ing biological samples in fluid Suspension. APPLICATIONS 0007. In one aspect, the invention may comprise anassem 0001. This application in a continuation application of bly of particles for stabilizing one or more biomolecules U.S. Ser. No. 13/081,436 filed Apr. 6, 2011, which claims the comprising: particulate material comprising particles and benefit of U.S. Provisional Application No. 61/321,269 filed said one or more biomolecules, wherein said biomolecules Apr. 6, 2010, which is incorporated herein by reference. are retained on an outer Surface layer of said particles and wherein said biomolecules have a water activity level sub FIELD OF THE INVENTION stantially less than 1. The above invention may further com prise an outer Surface layer comprising one or more stabiliz 0002 This invention relates generally to a method for ers. In some instances, one or more of the biomolecules may stabilizing biological samples. In particular the invention pro comprise a nucleic acid, a polypeptide, blood, serum, plasma, vides a method for stabilizing blood and blood components cell, tissue, sputum, mucus, cerebrospinal fluid, hair, urine, and other bodily fluids, bacterial, fungal, viral, animal and stool, semen, a metabolite, an antibody, a lipid, or a combi plant cell cultures in fluid Suspension. The invention also nation thereof. In other instances, one or more biomolecules provides a method for stabilizing tissue and organ samples. are selected form the group consisting of a bodily fluid, a tissue homogenate, a cell culture, a crude biological extract, a BACKGROUND OF THE INVENTION purified biologic, and any combination thereof. In yet other 0003 Water is a major component contributing to insta instances, one or more biomolecules are selected from the bility of collected biological material. Such biological mate group consisting of a plant extract, a microbial extract, an rial tends to be complex in nature and often contains damag animal extract, and any combination thereof. In the above ing entities such as nucleases, proteases, and other degrading invention, the biomolecules do not comprise d-Lysergic Acid and modifying enzymes and other chemicals that require an Diethylamide or polio virus. In the above invention, one or aqueous environment for activity. The damaging entities must more biomolecules may have a higher resistance from deg be immediately inactivated following sample collection to radation than a biomolecule not retained by said assembly. maintain biological material integrity. Additionally, certain The above invention may further comprise one or more bio biological materials, such as RNA, can spontaneously hydro molecules in contact with a solid support, wherein said solid lyze in the absence of exogenous enzyme activity, due to Support is selected from the group consisting of a Swab, a direct or metal-catalyzed addition of free water. sponge or a paper. In some instances, least a portion of said 0004 Some level of nuclease inactivation can beachieved biomolecules are recoverable from said assembly of the in the liquid state (patent 652864-RNA later). However, above invention. excess free water content can still cause hydrolysis. Dehydra 0008. In one aspect, the invention may comprise anassem tion has been used historically to achieve dry state stability. bly of particles comprising: particulate material comprising However, even active dehydration systems, using vacuum or one or more stabilizers on at least an outer Surface of said forced air, take hours to achieve Such stable state and require particulate material. The above invention may further com expensive equipment and thus are hard to implement at the prise one or more stabilizers located only on said outer Sur site of sample collection. Additionally, the time needed to face. In some instances, the above invention comprises an achieve dryness increases proportionately with an increase in assembly of particles that absorbs liquid upon contact of said sample size, thus contributing to further instability for large liquid with said assembly. The invention may further com samples. Thus, there is a need for a scalable method for prise an assembly of particles comprising a biomolecule that biological sample stabilization without refrigeration, via coexists as a thin chemically dehydrated surface film on the sample dehydration and the addition of stabilizers and inhibi particulate material. In different embodiments of this inven tors of degradation that can be performed in the seconds-to tion, a stabilizer may be selected from the group consisting of minutes time frame, without the use of mechanical drying anti-microbial agent, anti-oxidant, apoptosis inhibitors, equipment. buffer, chaotrope chelating agent, denaturing agent, deter 0005. The present invention provide instantaneous stabi gent, hydroxyl radical scavengers, hydroperoxide-removing lization of a biological sample, by rapid complexion of free entities, metal chelator, nuclease inhibitor, plasticizers, pro water in the sample and by diffusional addition of stabilizers tease inhibitors, protein modification inhibitor, protein pre to the sample, for transport and or archiving for Subsequent cipitants, protein stabilizers, reactive oxygen scavengers, and analysis of their constituents components, and propagation of reducing agent and any combination thereof. In some living entities, if stabilizing cultured cells. instances, the stabilizer is an oxidation inhibitor, a pyruvate inhibitor, an enzymatic activity inhibitor or a combination SUMMARY OF THE INVENTION thereof. In some embodiments of the invention, the particu 0006. The present invention provides methods, products, late material is a crystalline compound. In other embodiments and kits (having components described herein) for stabilizing of the invention, the particulate material is selected from the biological samples, including Solid tissues derived from group consisting of a monosaccharide, a disaccharide, a humans, animals and plants, as well as biological fluids Such polysaccharide, an organic salt, an inorganic salt, and any as blood urine, saliva, sputum, nasal discharges, lavages, tis combination thereof. In the above invention, a random pack Sue homogenates, by completely covering the sample in a ing of said particulate material may leave at least 20%, 25%, crystalline water-soluble compound and reducing the water 30%, 35%, 40% or more as interstitial space. The above activity level of the biological sample. The present invention invention may further comprise individual particles of said also provides methods for stabilizing extracts
Load more

Recommended publications
  • Product Catalog
    LOG UCT CATA 2021 PROD Favorite Foods, Inc | Somersworth, NH Your local & family owned Foodservice Distributor Table of Contents Appetizers............................................................. Page 3 Baked Goods........................................................ Page 4 Batters & Doughs.................................................. Page 9 Beans.................................................................... Page 11 Beverages............................................................. Page 12 Breader & Stuffing................................................. Page 17 Cereal & Waffles................................................... Page 18 Chemicals............................................................. Page 19 Condiments & Sauces........................................... Page 22 Crackers & Snacks................................................ Page 29 Dairy...................................................................... Page 30 Extracts & Syrups.................................................. Page 49 Frostings & Fillings.................................................Page 42 Fruit....................................................................... Page 44 Meat...................................................................... Page 45 Mixes & Flour........................................................ Page 60 Muffins & Pastries................................................. Page 64 Non Foods............................................................ Page 66 Oil & Shortening...................................................
    [Show full text]
  • Accents Stylish Details Accentuate the Tabletop
    Accents Stylish Details Accentuate The Tabletop don.com | 800.777.4DON Accents: Details that are emphasized by contrasting with their surroundings. On the tabletop, the addition of a single item can make all the difference in the world. A stainless steel basket, a stunning bud vase, a truly unique set of salt & pepper shakers can add just the touch of style your tabletop needs to become the perfect stage for your culinary creations. Contents Ambiance ...............................24 – 27 Creamers..................................17, 18 Menus ..............................................7 Serving Boards..........................10, 11 Teapots ..........................................22 Baskets ......................................3 – 5 Decanters .......................................22 Menu Stands ....................................7 Serving Platters .........................8 – 11 Tongs .......................................13, 15 Beverage Servers ............................22 Dinnerware ..........3, 12, 16, 24, 28, 30 Mini Cookware ........................29 – 31 Serving Utensils ......................12 – 15 Vases .............................................26 Beverage Service ....................20 – 23 Display Boxes ...................................5 Mini Serving Dishes .................28 – 31 Sugar Caddies ................................18 Votives ...........................................25 Bowls .........................................5, 12 Flight Caddies .................................21 Pitchers ..........................................23
    [Show full text]
  • Prisoner Diabetes Handbook
    Prisoner Diabetes Handbook A Guide to Managing Diabetes— for Prisoners, by Prisoners published by the southern poverty law center Why A Handbook for Prisoners With Diabetes? Diabetes is important. It is common, chronic, and can cause disabling complications. What you do for yourself to take care of your diabetes is the most important factor in your diabetes being well controlled. Very little diabetes education is provided in prisons. There are few organized programs for prisoners with diabetes. Experience has shown that others with diabetes are a good source of information about the disease. By cooperating and sharing, diabetics can help each other. A diabetes support group has been meeting at Great Meadow Correctional Facility in Comstock, New York since 1997. This group helps prisoners with diabetes to improve their diabetes management. People in the group learn from the experi- Diabetics at Comstock Prison would ences of other prisoners with diabetes. There is a lot of sup- be lost without the support group to port and good fellowship in help them learn about diabetes. the diabetes group. Sometimes the group chooses Jimmie Lee a project to do together. In the fall of 2003 we decided to write a handbook to share what we learned about diabetes self care in prison. This handbook is by prisoners, for prisoners. Our goal is to help you manage your diabetes better yourself. 3 FACTS ABOUT DIABETES Type 2 Diabetes The pancreas makes too little insulin and the insulin doesn’t Diabetes is not just one disease but several different diseases that work well. all cause the same basic problem: too much sugar in the blood.
    [Show full text]
  • The World of Flying Cars, Hover Boards and Holographic 3-D Images
    THE NEXT KID GENIUS Welcome to the world of flying cars, hover boards and holographic 3-D images. Science and technology have accelerated dramatically, and continues to grow and forge new paths in shaping and developing the world around us. We are at an age of scientific marvels, where nothing imagined is unattainable. The Next Genius is an original, scripted series that focuses on young and innovative children, hosted by a charismatic child genius about to embark on a journey to the future. The host will take the young viewers on a fun and exciting trip to some of the biggest and most prestigious science fairs and meet the best and brightest of the young science aficionados. We will talk to them about what sparked their ideas, how they went about creating their exhibitions, and what they hope to accomplish in the future. We also venture inside the “Kitchen Laboratories” of these young adventurers to learn fun and innovative ways to conduct scientific experiments and projects that we can teach the young viewers to do right at home, using objects found in most ordinary kitchens. This is a show that encourages children to learn, hypothesize and create. Each week will feature a different science fair and different young pioneer who will discuss and demonstrate the individual project he or she has been working on and also showcasing some simple, complementary science projects that viewers can re-create at home. Some of the top fair winners and the kitchen science experiments would include: Episode 1: Not A Good Day For Umbrellas Science Fair Project: How Weather Works - The power of the wind can even be strong enough to power large wind turbines to make electricity! In this experiment, find out how you can make your own instrument to measure the speed and power of the wind.
    [Show full text]
  • Beverages & More
    Beverages & more Coffee Item# Pack Size Description 366550 42/3 oz. High Altitude Papua Coffee New Guinea 366542 42/2.5 oz. Italian Dark Roast Coffee 366512 2/5 lb. 100% Colombian Regular Whole Bean 366507 42/2.5 oz. 100% Arabica Decaf 366505 42/2.5 oz. 100% Colombian with filters 366504 48/2 oz. 100% Arabica Decaf 366502 48/2.5 oz. 100% Arabica Regular 366560 12/1 lb. Cold Crew Coffee Filter Pack Espresso Item# Pack Size Description 360442 6/1000 gr. Espresso Whole Bean 360425 6/150 ct. Espresso Pod Decaf 360423 6/150 ct. Espresso Pod Regular 360419 32/250 gr. Espresso Ground Regular 360417 32/250 gr. Espresso Ground Decaf Water & Sparkling Beverage Item# Pack Size Description 365250 12/1 ltr. glass Ferrarelle Italian Sparkling Water 365260 15/16.9 oz. glass Ferrarelle Italian Sparkling Water 365270 24/11.2 oz. glass Ferrarelle Italian Sparkling Water 365265 15/16.9 oz. glass Natia Italian Still Water 365255 12/1 ltr. glass Natia Italian Still Water 365190 12/33.8 oz. San Pellegrino Carbonated Spring Water 365186 15/25.3 oz. San Pellegrino Carbonated Spring Water 365184 24/16.9 oz. plastic San Pellegrino Carbonated Spring Water 365180 24/16.9 oz. San Pellegrino Carbonated Spring Water 365175 24/8.45 oz. San Pellegrino Carbonated Spring Water 365206 12/33.8 oz. Panna Still Water 365350 24/16.9 oz. Panna Still Water 365229 4/6 pk. can Aranciata Rossa Sparkling Fruit Beverage 365217 4/6 pk. can Aranciata Sparkling Fruit Beverage 365215 4/6 pk.
    [Show full text]
  • Survival Kits for Every Need
    Survival Kits for Every Need Here is a variety of things you can add to a survival kit. Choose the items that seem appropriate to the moment, package in a pretty container, wrap with tissue and tie with ribbon. Add a card with the name of the survival kit and the meaning of the contents. SWEET & SOUR CANDY To help you appreciate the differences in others. A STICK OF GUM To remind you to stick with it To remind you to "chews" the right thing A CHOCOLATE KISS To remind you that someone loves you. A TOOTSIE ROLL To remind you not bite off more than you can chew. SMARTIES To remind you that you are smart. STARBURST To give you a burst of energy on the days you don't have any A PAPER CLIP To help keep things together when they seem to be getting out of control. PENCIL For the next time somebody says "get the lead out" (thanks Karen P.) BALLOON To remind you not to blow up (thanks Karen P.) A TISSUE To wipe away a tear-- your own or someone else's. A CANDY KISS To say "I love you" in a sweet way. ERASER To remind you that everyday you can start with a clean slate. A POEM To share the beauty of words. A PENNY So that you will never have to say, "I'm broke." A MARBLE In case someone says "You've lost all your marbles!" EYES (googly ones) To help you see the good in others (thanks Karen P.) PACKET OF SEEDS To remind you that you are always growing! CONFETTI To celebrate your joys of life.
    [Show full text]
  • Rethink Your Drink
    University of Hawai’i at Manoa, College of Tropical Agriculture & Human Resources, Department of Family & Consumer Sciences, Department of Human Nutrition, Food and Animal Science Cooperative Extension Service, Nutrition Education for Wellness www.ctahr.hawaii.edu/NEW Rethink Your Drink Choosing healthy beverages is a great first step to an overall healthy diet. Americans are drinking more soda and other sweetened beverages than ever. Many drinks now come in larger cups and cans, containing more than one 8-ounce serving. Drinking sweetened beverages may lead to weight gain, overweight, obesity, and type 2 diabetes. Eat your calories rather than drink your calories. How much fluid do you need? • Children: ~4 to 11 cups of fluids a day • Adults: ~9 to 13 cups of fluids a day • Amounts depend on age, gender, level of physical activity, altitude and climate. During hot weather, you will need more fluids, but don’t go by thirst alone. To prevent dehydration, drink plenty of water throughout the day, even before going outdoors. One way to tell if you are drinking enough fluids is to check the color of your urine. Your urine should be light yellow in color. If it is a dark color, you need to drink more water. Benefits of Drinking Water: Your Body’s Perfect Drink Drinking water is the best strategy to rethink your drink. Water is the perfect beverage— water is calorie-free, sugar-free, fat-free, and almost free (when it’s from the tap). Water is the best choice to stay hydrated before, during, and after physical activity.
    [Show full text]
  • Recipe Carb List 11-22-19
    Gladstone School District Page 1 Recipe Carbohydrates List Nov 22, 2019 Between 0 and 100 Grams Carbohydrates No. Description Portion Size (Grams) BREAD 500305 AZTEC GRAIN SALAD 1 CUP 53.56 000347 BAGELS,PLAIN,ENRICHED 1 EACH 37.19 500010 BAKING POWDER BISCUITS 1 EACH 22.09 500011 BANANA BREAD SQUARES SERVING 25.56 001086 BISCUITS: PLAIN PURCH (2oz) EACH 18.85 000355 BISCUITS: PLAIN,PURCH (2.5") EACH 18.85 500037 BREAD STUFFING SERVINGS 22.64 500040 BROWN BREAD EACH 19.27 000117 Brown Rice .5 cup 33.00 500027 BROWN RICE PILAF 1/2 CUP 30.36 500088 CORNBREAD SERVINGS 18.03 000121 Cornbread 2oz 26.58 500089 CORNBREAD STUFFING SERVINGS 21.19 000232 CRACKERS 4 EACH 8.89 000233 CRACKERS,GRAHAM 4 EACH 44.03 000353 ENGLISH MUFFINS,PLAIN,TOASTED 1/2 EACH 13.69 500099 FRIED RICE 3/4 CUP 29.37 000169 Fritos 2oz 40.00 500111 ITALIAN BREAD EACH 28.23 500119 MASTER MIX 1/2 CUP 40.68 500325 MEDITERRANEAN QUINOA SALAD 3/4 CUP 22.66 500125 MUFFIN SQUARES SERVINGS 16.87 500133 OATMEAL MUFFIN SQUARES SERVINGS 34.51 500303 OODLES OF NOODLES CUP 43.45 500137 ORANGE RICE PILAF 1/2 CUP 27.85 500141 PANCAKES EACH 16.26 500327 PEPPY QUINOA 1/2 CUP 28.60 500147 PIZZA CRUST SERVINGS 26.11 500155 POURABLE PIZZA CRUST SERVINGS 26.02 500163 RICE-VEGETABLE CASSEROLE 2/3 CUP 19.62 500164 ROLLS (YEAST) EACH 29.80 500173 SPANISH RICE 1/3 CUP 13.69 000237 Stuffing 1/4 cup 35.44 500181 SWEET POTATO- PLUM BREAD SQUAR SERVING 46.48 000326 TOAST, MIXED GRAIN BREAD SLICE 11.35 000324 TOAST, WHITE BREAD SLICE 12.03 000367 TOAST,RAISIN 1 SLICE 13.66 000325 TOAST,WHOLE-WHEAT BREAD
    [Show full text]
  • Grand Total Awards 2,200,000.00
    Gail Sharry, Executive Director NHPS Food Service P: (475) 220-1610 F: (203) 946-7650 To: New Haven Board of Education Finance and Operations Committee From: Thomas Lamb, Chief Operating Officer Gail Sharry, Executive Director Michael Gormany, City Budget Director Date: May 28, 2021 Re: Award of Contract for NHPS Food Service for Grocery Items Purchases for fiscal year 2021-22 Executive Summary: Approval is requested for an award of contract(s) under RFP# 2021-04-1371 for the purchase of Grocery items for fiscal year 2021-22 for NHPS Food Service. Minority Renewal or Award of or Contract/Agreement City Award Vendor Women Vendor Vendor Name City, State, Zip Amount not Address Owned Number to Exceed Small Business? Thurston Wallingford, CT Award 43356 30 Thurston Dr $1,800,000 Foods, Inc 06492 Nardone Bros 420 New Hanover Twp, PA Award 50643 $150,000 Baking Co Inc. Commerce Blvd 18706 Gilman Cheese 300 S. Riverside Award TBD Gilman, WI 54433 $100,000 Corporation Drive Chinese Food 5600 Elmhurst Oviedo. FL Award 52652 $100,000 Solutions, Inc Cir. 32765 2601 Blake Award TBD Ripple Denver, CO 80205 $50,000 Street Suite 300 Grand Total 2,200,000.00 Awards Contract or Agreement #: TBD Funding Source & Account #: 25215200-55587 Key Questions: (Please have someone ready to discuss the details of each question during the Finance & Operations meeting or this proposal might not be advanced for consideration by the full Board of Education): Central Kitchen | 75 Barnes Avenue, New Haven, CT 06513 http://www.nhpscnp.org/ Excellence in Education. Gail Sharry, Executive Director NHPS Food Service P: (475) 220-1610 F: (203) 946-7650 1.
    [Show full text]
  • Price Listing Does Not Guarantee Coverage West Virgini
    West Virginia Medicaid State Maximum Allowable Cost (SMAC) List Effective Jan 31, 2014 ‑ Version 2014.05 Disclaimer: Price listing does not guarantee coverage Old SMAC Current Generic_Name Effective_Date Price SMAC Price 0.9 % SODIUM CHLORIDE PGGYBK PRT 0.04001 0.03440 1/25/2013 0.9 % SODIUM CHLORIDE PGY VL PRT 0.07096 0.07291 2/22/2013 0.9 % SODIUM CHLORIDE 0.9 % IV SOLN 0.00141 0.00165 12/27/2013 0.9 % SODIUM CHLORIDE 0.9 % VIAL 0.04800 0.05830 1/25/2013 ABACAVIR SULFATE 300 MG TABLET 6.27295 6.21453 9/6/2013 ACARBOSE 100 MG TABLET 0.50679 0.40200 7/12/2013 ACARBOSE 25 MG TABLET 0.46270 0.26023 1/3/2014 ACARBOSE 50 MG TABLET 0.35054 0.33353 1/3/2014 ACEBUTOLOL HCL 200 MG CAPSULE 0.21353 0.21350 12/14/2012 ACETAMINOPHEN 100 MG/ML DROPS 0.15340 0.11667 4/12/2013 ACETAMINOPHEN 120 MG SUPP.RECT 0.16289 0.19717 11/22/2013 ACETAMINOPHEN 160 MG/5ML ELIXIR 0.01968 0.01083 9/27/2013 ACETAMINOPHEN 160 MG/5ML LIQUID 0.01297 0.00932 9/27/2013 ACETAMINOPHEN 160 MG/5ML ORAL SUSP 0.02397 0.02412 5/24/2013 ACETAMINOPHEN 325 MG SUPP.RECT 0.00000 0.45850 12/1/2012 ACETAMINOPHEN 325 MG TABLET 0.00616 0.00830 1/25/2013 ACETAMINOPHEN 500 MG CAPSULE 0.02940 0.01093 5/17/2013 ACETAMINOPHEN 500 MG TABLET 0.00951 0.01093 5/17/2013 ACETAMINOPHEN 650 MG SUPP.RECT 0.21683 0.21680 12/14/2012 ACETAMINOPHEN 80 MG TAB CHEW 0.04850 0.04450 3/1/2013 ACETAMINOPHEN 80MG/0.8ML DROPS 0.27720 0.17160 4/19/2013 ACETAMINOPHEN WITH CODEINE 120-12MG/5 (5 ML) SOLUTION 0.00000 0.15890 12/1/2012 ACETAMINOPHEN WITH CODEINE 120-12MG/5 SOLUTION 0.01490 0.01485 4/26/2013 ACETAMINOPHEN
    [Show full text]
  • Materials Week 7 Display Board Juice Drink Hi-C Flashin Fruit
    Juice Board – Week 7 Activity Description What Has More Sugar? Materials Week 7 display board Juice Drink Hi-C Flashin Fruit Punch – juice drink juice box 6.75 fl.oz 24 grams of sugar 6 sugar packets – 6 teaspoons of sugar Soda Coca-Cola 90 calories per can 7.5 fl.oz 25 grams of sugar 6 sugar packets –6 teaspoons of sugar 100% Juice Juicy Juice or Mott’s 100% juice box 6.75 fl oz 24 grams of sugar 6 sugar packets – 6 teaspoons of sugar Domino sugar packets –18 are needed for activity; pack at least 30 so there are more than are needed for distribution Reinforcers – Sugar scrub Basket/container for reinforcers Raffle box Raffle slips Parent handouts Evaluation form Table for supporting board (folding table) Raffle prize to give away for current week – Fruit basket (mangos, oranges, apples) Raffle prize for following week – Set of Pyrex measuring cups – FOR DISPLAY ONLY Raffle prize winner’s name Target Audience Parents of Pre – School Children Table/Board Set Up Place board on folding table Place raffle box, pens/pencils, and raffle slips on table Place parent handouts on table Place all activity materials on table Place raffle prize and raffle winner’s name on table Place raffle prize for following week on table (If there is space) Activity: Parent will learn that 100% juice, juice drinks, and soda all contain the same amount of sugar. 1. The student will set the four beverages on the table and have several sugar packets available. 2. The student will greet the parent and ask him/her if they want to enter their name in the weekly raffle or receive a giveaway.
    [Show full text]
  • Cocktails Signature Martinis
    Cocktails Signature Martinis Skinny Cucumber Black Forest Ham Chocolate-tini Italian Wedding Ketel One Vodka, Zing Zang Your choice of Godiva Mint Mule Cake Martini Bloody Mary Mix, tabasco, Chocolate Liqueur or Ketel Cucumber Mint Smirnoff Vanilla Vodka, Worcestershire sauce, salt Godiva White Chocolate Botanical Vodka, squeeze white crème de cacao, and pepper. Skewered with Liqueur, creamer and of lime & ginger beer Amaretto. Pineapple and a slice of black forest ham, Smirnoff Whipped Cream Cranberry juice pickle and olive Vodka Salvino 75 Brut Champagne, Espresso Martini Peach Orange Tanqueray London Dry Gin, Bahama Mama Ketal One Vodka, Baileys squeeze of lemon and Captain Morgan Coconut Blossom Martini Original Irish Cream simple syrup Rum, OJ, pineapple juice Ketel One Botanical Peach Liqueur, Grind Espresso and grenadine and Orange Blossom Vodka Spirit and Amaretto. and Orange Juice w/ Rye Manhattan Bulleit Rye, Sweet Diamond Eyes cranberry float Cosmopolitan Vermouth, bitters and a Smirnoff Raspberry and Ketel One Vodka, Triple Appletini cherry. Stirred over ice and Strawberry flavored vodka, Sec, cranberry juice and a Smirnoff green apple served up peach schnapps, lemon- splash of lime juice vodka, butterscotch liqueur lime soda, sour &grenadine and sweet and sour. Red Sangria Captain Runner Salvino’s French Garnished with a cherry Red wine, splash of Captain Morgan Original Martini Hennessy V.S., orange juice Spiced Rum, Crème De Smirnoff Raspberry Vodka, Belvedere Martini and seasoned fruit. Served Banana, orange juice and
    [Show full text]