Drug Interactions (Portrait)

GUIDE TO DRUG COMBINATIONS

Combining certain drugs can be incredibly dangerous to your health. Even combinations of over-the-counter drugs and legal recreational substances can prove deadly. Refer to this chart and the resources below if you’re unsure about the combined effects of what you’re taking.

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DRUG COMBINATIONS WARNING EFFECTS EXAMPLES Liver damage Acetominophen DANGER Tylenol (common ingredient in many OTC pain and cold remedies)

Increased risk of alcohol overdose ADD/ADHD medications Caution Adderall, Concerta, Ritalin, Vyvanse

Increased risk of alcohol overdose, liver damage (tylenol) Alavert, Allegra, Benedryl, Claritin, Dimetapp, Sudafed, Triaminic, Tylenol Allergy/Cold DANGER medications Allergy, Zyrtec

Anxiety, depression, suicidal thoughts, increased risk of alcohol overdose Amphetamines Caution see ADHD medications above; also methamphetamine

Antibiotics/Antifungals DANGER Rapid heartbeat, sudden change in blood pressure, stomach pain, vomiting, Flagyl, Macrodantin, Nizoral, Seromycin, Tindamax headache, flushing, liver damage

Increased risk for overdose, increased feelings of depression or hopeless- Antidepressants/ DANGER Celexa, Effexor, Lexapro, Paxil, Prozac, Wellbutrin, Zolo Antianxiety medications ness, risk of suicide

Antinausea medication Caution Increased risk for overdose Dramamine, Antivert

Ulcers, stomach bleeding, liver problems Arthritis medications Caution Celebrex, Voltaren, Naprosyn

Increased risk for overdose, difficulty breathing, impaired motor control Anafranil, Ativan, Klonopin, Librium, Lorazepam, Paxil, Restoril, Valium, Benzodiazapines DANGER Versed, Xanax

Cannabis Nausea, vomiting, sweating, anxiety, panic, paranoia, psychosis Caution (Marijuana)

Liver damage; increased risk of heart aack, cardiomyopathy (enlargement Combination produces toxic metabolite, "cocaethylene" Cocaine DANGER and weakening of heart), heart arrhythmia, stroke; increased violent thoughts and behaviors.

Cough remedies Caution Dizziness, drowsiness, difficulty concentrating, increased risk for overdose Delsym, Robitussin (dextromethorphan), guaifenesin, codeine Alcohol Abnormally low blood sugar levels, nausea, vomiting, headache, rapid heart- Glucophage Diabetes medications DANGER beat, sudden changes in blood pressure

Nausea, vertigo, respiratory failure, death Gamma hydroxybutyrate, Gamma butyrolactone GHB/GBL DANGER

Upset stomach, bleeding, ulcers, rapid heartbeat, liver damage Headache remedies Caution Advil, Aleve, Excedrin, Motrin, Tylenol (acetominophen/Tylenol)

Heartburn/GERD Rapid heartbeat, sudden changes in blood pressure, increased alcohol effect Tagamet, Zantac Caution medications

High blood pressure DANGER Dizziness, fainting, heart arrhythmia Accupril, Lopressor medications

Dissociation, psychosis, heart palpitations, elevated blood pressure, Ketamine DANGER respiratory failure, death

Impaired cognitive functioning, increased risky behavior, increased risk of MDMA Caution Ecstacy and synthetic analog "Molly" alcohol overdose

Dissociation, rapid heartrate, seizures, death MXE DANGER Methoxetamine

Opiates & opioid Death by overdose, difficulty breathing Demerol, Fentanyl, Heroin, Hydrocodone, Oxycodone, Oxycontin, DANGER painkillers Percocet, Tramadol, Vicodin

Seizure medications Caution Drowsiness, dizziness, increased risk of seizures. Klonopin, Dilantin

Slowed/difficulty breathing, impaired motor control Sleep aids DANGER Ambien, Lunesta, Sominex, Unisom

Liver damage Statins DANGER Crestor, Lipitor, Zocor

Erratic heart beat, "jiers" Amphetamines Caution Adderall, Concerta, Ritalin, Vyvanse, methamphetamine

Increased risk of addiction Cocaine Caution

Overheating, dangerously rapid heart rate, death Ecstacy and synthetic analog "Molly" Caffeine MDMA DANGER

Death from heart failure Amphetamines DANGER Adderall, Concerta, Ritalin, Vyvanse, methamphetamine

Increased risk of death by overdose Alcohol DANGER combination produces toxic metabolite, "cocaethylene"

Opiates & opioid DANGER Death Demerol, Fentanyl, Heroin, Hydrocodone, Oxycodone, Oxycontin, Percocet, painkillers Tramadol, Vicodin Cocaine Elevated blood pressure, heart rate, body temp leading to severe organ Ecstacy and synthetic analogs (e.g. "Molly") MDMA DANGER damage, risk of sudden death; permanent impairment to reward centers in brain

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