Supplementary Table 1. Genes significantly down- or upregulated with age in all organs investigated in mouse, rat and sheep.

Non-Cell Cycle Downregulated Bovine Gene Symbol Gene Title ALDH18A1 aldehyde dehydrogenase 18 family, member A1 APLNR apelin receptor ARMCX6 armadillo repeat containing, X-linked 6 CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit CD276 CD276 molecule cadherin 11, type 2, OB-cadherin (osteoblast) /// similar to Cadherin-11 CDH11 /// LOC790083 precursor CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) CIRBP cold inducible RNA binding protein CKAP4 cytoskeleton-associated protein 4 COL1A1 collagen, type I, alpha 1 COL1A2 collagen, type I, alpha 2 DACT1 dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) DBN1 drebrin 1 DLK1 delta-like 1 homolog (Drosophila) DZIP1 DAZ interacting protein 1 E2F8 E2F transcription factor 8 ELN Elastin EMILIN1 elastin microfibril interfacer 1 EZH2 enhancer of zeste homolog 2 (Drosophila) FKBP10 FK506 binding protein 10, 65 kDa FN1 fibronectin 1 FNDC1 fibronectin type III domain containing 1 FOXM1 forkhead box M1 FSTL1 follistatin-like 1 GEFT RAC/CDC42 exchange factor GPX7 glutathione peroxidase 7 H2AFX H2A histone family, member X HMGN2 high-mobility group nucleosomal binding domain 2 IGF2 insulin-like growth factor 2 (somatomedin A) IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 KIF20A kinesin family member 20A LAMB1 laminin, beta 1 LHFPL2 lipoma HMGIC fusion partner-like 2 LOC514296 similar to 5-nucleotidase domain containing 2 LOXL2 lysyl oxidase-like 2 LPAR4 lysophosphatidic acid receptor 4 LRRC17 leucine rich repeat containing 17 MAGED1 melanoma antigen family D, 1 MAGED2 melanoma antigen family D, 2 MARCKSL1 MARCKS-like 1 MDK midkine (neurite growth-promoting factor 2) MEST mesoderm specific transcript homolog (mouse) MFAP2 microfibrillar-associated protein 2 MTHFD2L Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like MXD3 MAX dimerization protein 3 NNAT neuronatin NRM nurim (nuclear envelope membrane protein) PEG3 paternally expressed 3 PLAGL1 pleiomorphic adenoma gene-like 1 PLXND1 plexin D1 PTN pleiotrophin PYCR1 pyrroline-5-carboxylate reductase 1 RFC3 replication factor C (activator 1) 3, 38kDa ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) SERF1A small EDRK-rich factor 1A (telomeric) SERTAD4 SERTA domain containing 4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, SMARCA1 subfamily a, member 1 SMO smoothened homolog (Drosophila) SMTNL2 smoothelin-like 2 transcription factor 3 (E2A immunoglobulin enhancer binding factors TCF3 E12/E47) TDG thymine-DNA glycosylase TEAD2 TEA domain family member 2 THBS2 thrombospondin 2 TNC tenascin C TSPAN6 tetraspanin 6 UHRF1 ubiquitin-like with PHD and ring finger domains 1 VCAN versican Non-Cell Cycle Upregulated ADHFE1 alcohol dehydrogenase, iron containing, 1 B2M beta-2-microglobulin BOLA-DMA major histocompatibility complex, class II, DM alpha-chain, expressed major histocompatibility complex, class II, DRB3 /// similar to major BoLA-DRB3 /// LOC786695 histocompatibility complex, class II, DRB3 C4A complement component 4A CCL5 chemokine (C-C motif) ligand 5 CD302 CD302 molecule CD74 CD74 molecule, major histocompatibility complex, class II invariant chain CTSS cathepsin S DBP D site of albumin promoter (albumin D-box) binding protein EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) FAS Fas (TNF receptor superfamily, member 6) FMO1 flavin containing monooxygenase 1 GSTA1 /// GSTA1 /// glutathione S-transferase alpha 1 /// glutathione S-transferase A1 /// similar to LOC100138641 glutathione S-transferase A1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin- HERPUD1 like domain member 1 MAPT microtubule-associated protein tau METTL7A methyltransferase like 7A NR1D1 nuclear receptor subfamily 1, group D, member 1 NUPR1 nuclear protein, transcriptional regulator, 1 OSGIN1 oxidative stress induced growth inhibitor 1 PARP14 poly (ADP-ribose) polymerase family, member 14 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional PSMB8 peptidase 7) proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional PSMB9 peptidase 2) SELENBP1 selenium binding protein 1 SLC25A33 solute carrier family 25, member 33 STAT1 signal transducer and activator of transcription 1, 91kDa SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 TGOLN2 trans-golgi network protein 2 USP18 ubiquitin specific peptidase 18 Cell Cycle Downregulated* ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) AURKA aurora kinase A BIRC5 baculoviral IAP repeat-containing 5 BRCA1 Breast cancer 1, early onset BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) CAPN6 calpain 6 CCDC99 coiled-coil domain containing 99 CCNA2 /// LOC786906 cyclin A2 /// similar to Cyclin A2 CCNB1 cyclin B1 CCNB2 cyclin B2 CCNF cyclin F CDC20 cell division cycle 20 homolog (S. cerevisiae) CDCA2 cell division cycle associated 2 CDCA3 cell division cycle associated 3 CDCA7 cell division cycle associated 7 CDCA8 cell division cycle associated 8 CDK1 cyclin-dependent kinase 1 CDK4 cyclin-dependent kinase 4 CDT1 chromatin licensing and DNA replication factor 1 CENPI centromere protein I CENPN centromere protein N CHEK1 CHK1 checkpoint homolog (S. pombe) CKS1B CDC28 protein kinase regulatory subunit 1B ECT2 epithelial cell transforming sequence 2 oncogene ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) FAM83D Protein FAM83D FGD1 FYVE, RhoGEF and PH domain containing 1 FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) GPC3 glypican 3 GPSM2 G-protein signaling modulator 2 (AGS3-like, C. elegans) H2AFY2 H2A histone family, member Y2 H3F3B H3 histone, family 3B (H3.3B) HMGB2 High-mobility group box 2 IQGAP3 IQ motif containing GTPase activating protein 3 KIF22 kinesin family member 22 KNTC1 kinetochore associated 1 mitotic checkpoint component Mad2 /// MAD2 mitotic arrest deficient-like 1 MAD2 /// MAD2L1 (yeast) MCM2 similar to KIAA0030 MCM3 minichromosome maintenance complex component 3 MCM4 minichromosome maintenance complex component 4 MCM5 minichromosome maintenance complex component 5 MCM6 minichromosome maintenance complex component 6 MCM7 minichromosome maintenance complex component 7 MMP23B matrix metallopeptidase 23B MYH10 myosin, heavy chain 10, non-muscle NCAPD2 non-SMC condensin I complex, subunit D2 NCAPG2 non-SMC condensin II complex, subunit G2 NCAPH non-SMC condensin I complex, subunit H NDC80 NDC80 homolog, kinetochore complex component (S. cerevisiae) NUSAP1 nucleolar and spindle associated protein 1 PRC1 protein regulator of cytokinesis 1 PTK7 PTK7 protein tyrosine kinase 7 RACGAP1 Rac GTPase activating protein 1 RAD51AP1 RAD51 associated protein 1 RRM1 ribonucleotide reductase M1 SGOL1 shugoshin-like 1 (S. pombe) SKA3 spindle and kinetochore associated complex subunit 3 TACC3 transforming, acidic coiled-coil containing protein 3 TIMELESS timeless homolog (Drosophila) TK1 thymidine kinase 1, soluble TOP2A topoisomerase (DNA) II alpha 170kDa TRIP13 thyroid hormone receptor interactor 13 UBE2C ubiquitin-conjugating enzyme E2C ZWILCH Zwilch, kinetochore associated, homolog (Drosophila) Cell Cycle Upregulated* CREBL2 cAMP responsive element binding protein-like 2 GLUL glutamate-ammonia ligase * Genes with known functions specific to the cell cycle are indicated separately, in order to differentiate them from genes that may encode regulatory functions that drive the decline in cell proliferation that occurs with age.