Overview of the Skeleton: Classification and Structure of Bones and Cartilages 9 Bone Markings
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Applications of Chondrocyte-Based Cartilage Engineering: an Overview
Hindawi Publishing Corporation BioMed Research International Volume 2016, Article ID 1879837, 17 pages http://dx.doi.org/10.1155/2016/1879837 Review Article Applications of Chondrocyte-Based Cartilage Engineering: An Overview Abdul-Rehman Phull,1 Seong-Hui Eo,1 Qamar Abbas,1 Madiha Ahmed,2 and Song Ja Kim1 1 Department of Biological Sciences, College of Natural Sciences, Kongju National University, Gongjudaehakro 56, Gongju 32588, Republic of Korea 2Department of Pharmacy, Quaid-i-Azam University, Islamabad 45320, Pakistan Correspondence should be addressed to Song Ja Kim; [email protected] Received 14 May 2016; Revised 24 June 2016; Accepted 26 June 2016 Academic Editor: Magali Cucchiarini Copyright © 2016 Abdul-Rehman Phull et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Chondrocytes are the exclusive cells residing in cartilage and maintain the functionality of cartilage tissue. Series of biocomponents such as different growth factors, cytokines, and transcriptional factors regulate the mesenchymal stem cells (MSCs) differentiation to chondrocytes. The number of chondrocytes and dedifferentiation are the key limitations in subsequent clinical application of the chondrocytes. Different culture methods are being developed to overcome such issues. Using tissue engineering and cell based approaches, chondrocytes offer prominent therapeutic option specifically in orthopedics for cartilage repair and to treat ailments such as tracheal defects, facial reconstruction, and urinary incontinence. Matrix-assisted autologous chondrocyte transplantation/implantation is an improved version of traditional autologous chondrocyte transplantation (ACT) method. An increasing number of studies show the clinical significance of this technique for the chondral lesions treatment. -
Musculoskeletal Morphing from Human to Mouse
Procedia IUTAM Procedia IUTAM 00 (2011) 1–9 2011 Symposium on Human Body Dynamics Musculoskeletal Morphing from Human to Mouse Yoshihiko Nakamuraa,∗, Yosuke Ikegamia, Akihiro Yoshimatsua, Ko Ayusawaa, Hirotaka Imagawaa, and Satoshi Ootab aDepartment of Mechano-Informatics, Graduate School of Information and Science and Technology, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan bBioresource Center, Riken, 3-1-1 Takanodai, Tsukuba-shi, Ibaragi, Japan Abstract The analysis of movement provides various insights of human body such as biomechanical property of muscles, function of neural systems, physiology of sensory-motor system, skills of athletic movements, and more. Biomechan- ical modeling and robotics computation have been integrated to extend the applications of musculoskeletal analysis of human movements. The analysis would also provide valuable means for the other mammalian animals. One of current approaches of post-genomic research focuses to find connections between the phenotype and the genotype. The former means the visible morphological or behavioral expression of an animal, while the latter implies its genetic expression. Knockout mice allows to study the developmental pathway from the genetic disorders to the behavioral disorders. Would musculoskeletal analysis of mice also offer scientific means for such study? This paper reports our recent technological development to build the musculoskeletal model of a laboratory mouse. We propose mapping the musculoskeletal model of human to a laboratory mouse based on the morphological similarity between the two mammals. Although the model will need fine adjustment based on the CT data or else, we can still use the mapped musculoskeletal model as an approximate model of the mouse’s musculoskeletal system. -
Pg 131 Chondroblast -> Chondrocyte (Lacunae) Firm Ground Substance
Figure 4.8g Connective tissues. Chondroblast ‐> Chondrocyte (Lacunae) Firm ground substance (chondroitin sulfate and water) Collagenous and elastic fibers (g) Cartilage: hyaline No BV or nerves Description: Amorphous but firm Perichondrium (dense irregular) matrix; collagen fibers form an imperceptible network; chondroblasts produce the matrix and when mature (chondrocytes) lie in lacunae. Function: Supports and reinforces; has resilient cushioning properties; resists compressive stress. Location: Forms most of the embryonic skeleton; covers the ends Chondrocyte of long bones in joint cavities; forms in lacuna costal cartilages of the ribs; cartilages of the nose, trachea, and larynx. Matrix Costal Photomicrograph: Hyaline cartilage from the cartilages trachea (750x). Thickness? Metabolism? Copyright © 2010 Pearson Education, Inc. Pg 131 Figure 6.1 The bones and cartilages of the human skeleton. Epiglottis Support Thyroid Larynx Smooth Cartilage in Cartilages in cartilage external ear nose surface Cricoid Trachea Articular Lung Cushions cartilage Cartilage of a joint Cartilage in Costal Intervertebral cartilage disc Respiratory tube cartilages in neck and thorax Pubic Bones of skeleton symphysis Meniscus (padlike Axial skeleton cartilage in Appendicular skeleton knee joint) Cartilages Articular cartilage of a joint Hyaline cartilages Elastic cartilages Fibrocartilages Pg 174 Copyright © 2010 Pearson Education, Inc. Figure 4.8g Connective tissues. (g) Cartilage: hyaline Description: Amorphous but firm matrix; collagen fibers form an imperceptible network; chondroblasts produce the matrix and when mature (chondrocytes) lie in lacunae. Function: Supports and reinforces; has resilient cushioning properties; resists compressive stress. Location: Forms most of the embryonic skeleton; covers the ends Chondrocyte of long bones in joint cavities; forms in lacuna costal cartilages of the ribs; cartilages of the nose, trachea, and larynx. -
GLOSSARY of MEDICAL and ANATOMICAL TERMS
GLOSSARY of MEDICAL and ANATOMICAL TERMS Abbreviations: • A. Arabic • abb. = abbreviation • c. circa = about • F. French • adj. adjective • G. Greek • Ge. German • cf. compare • L. Latin • dim. = diminutive • OF. Old French • ( ) plural form in brackets A-band abb. of anisotropic band G. anisos = unequal + tropos = turning; meaning having not equal properties in every direction; transverse bands in living skeletal muscle which rotate the plane of polarised light, cf. I-band. Abbé, Ernst. 1840-1905. German physicist; mathematical analysis of optics as a basis for constructing better microscopes; devised oil immersion lens; Abbé condenser. absorption L. absorbere = to suck up. acervulus L. = sand, gritty; brain sand (cf. psammoma body). acetylcholine an ester of choline found in many tissue, synapses & neuromuscular junctions, where it is a neural transmitter. acetylcholinesterase enzyme at motor end-plate responsible for rapid destruction of acetylcholine, a neurotransmitter. acidophilic adj. L. acidus = sour + G. philein = to love; affinity for an acidic dye, such as eosin staining cytoplasmic proteins. acinus (-i) L. = a juicy berry, a grape; applied to small, rounded terminal secretory units of compound exocrine glands that have a small lumen (adj. acinar). acrosome G. akron = extremity + soma = body; head of spermatozoon. actin polymer protein filament found in the intracellular cytoskeleton, particularly in the thin (I-) bands of striated muscle. adenohypophysis G. ade = an acorn + hypophyses = an undergrowth; anterior lobe of hypophysis (cf. pituitary). adenoid G. " + -oeides = in form of; in the form of a gland, glandular; the pharyngeal tonsil. adipocyte L. adeps = fat (of an animal) + G. kytos = a container; cells responsible for storage and metabolism of lipids, found in white fat and brown fat. -
Bone Markings / Features on Bones
08/05/2016 Bone Markings : Skeletal System Search Custom Search Like Tweet Home Health News Human Body Biology Chemistry Glossary Textbooks Bone Disorders Ads by Google ► Bone Tissue ► Bone Marrow ► Human Skull Bone ► Bone on Bone Knee Sun 8 May 2016 Bone Markings / Features on Bones Human Body Study Section Bone markings and the features of bones (including the correct words used to describe them) are often required by firstlevel courses in human anatomy and associated health science subjects. It is important to be familiar with the terminology used to Human Body Index refer to bone markings in order to communicate effectively with professionals involved in healthcare, research, forensics, and Health Glossary related disciplines. More about Bones and the Skeletal System: The following terms used to describe bone markings or features on bones are in alphabetical order with short definitions: Human Skeleton Axial and Appendicular Word / Term Meaning / Description Type of Example(s) Skeleton (Bone Marking or bone The Structure and Feature) marking Functions of Bones Types of Bones 1. Angle A corner Feature of Inferior angle (lower) and superior angle (upper) are Bone Markings & Features shape of bone the rounded angles or "corners" of the scapula. on Bones Disorders of the Skeletal 2. Body The main portion of a bone The diaphysis of long bones such as the humerus. System Curvature of the Spine 3. Condyle Rounded bump or large rounded Process The medial condyle of the femur (bone), upperleg. prominence. Such rounded surfaces forms joints Types of Joints usually fit into a fossa on another bone to Specific bones: form a joint. -
The Epiphyseal Plate: Physiology, Anatomy, and Trauma*
3 CE CREDITS CE Article The Epiphyseal Plate: Physiology, Anatomy, and Trauma* ❯❯ Dirsko J. F. von Pfeil, Abstract: This article reviews the development of long bones, the microanatomy and physiology Dr.med.vet, DVM, DACVS, of the growth plate, the closure times and contribution of different growth plates to overall growth, DECVS and the effect of, and prognosis for, traumatic injuries to the growth plate. Details on surgical Veterinary Specialists of Alaska Anchorage, Alaska treatment of growth plate fractures are beyond the scope of this article. ❯❯ Charles E. DeCamp, DVM, MS, DACVS athologic conditions affecting epi foramen. Growth factors and multipotent Michigan State University physeal (growth) plates in imma stem cells support the formation of neo ture animals may result in severe natal bone consisting of a central marrow P 2 orthopedic problems such as limb short cavity surrounded by a thin periosteum. ening, angular limb deformity, or joint The epiphysis is a secondary ossifica incongruity. Understanding growth plate tion center in the hyaline cartilage forming anatomy and physiology enables practic the joint surfaces at the proximal and distal At a Glance ing veterinarians to provide a prognosis ends of the bones. Secondary ossification Bone Formation and assess indications for surgery. Injured centers can appear in the fetus as early Page E1 animals should be closely observed dur as 28 days after conception1 (TABLE 1). Anatomy of the Growth ing the period of rapid growth. Growth of the epiphysis arises from two Plate areas: (1) the vascular reserve zone car Page E2 Bone Formation tilage, which is responsible for growth of Physiology of the Growth Bone is formed by transformation of con the epiphysis toward the joint, and (2) the Plate nective tissue (intramembranous ossifica epiphyseal plate, which is responsible for Page E4 tion) and replacement of a cartilaginous growth in bone length.3 The epiphyseal 1 Growth Plate Closure model (endochondral ossification). -
Musculo-Skeletal System
Musculo-Skeletal System (Trunk, Limbs, and Head) somite: ectoderm dermatome General Statements: myotome Bilaterally, paraxial mesoderm become sclerotome neural crest somites and somitomeres. (Somitomeres develop ros- intermediate tral to the notochord in the head. They are like somites, but mesoderm neural tube smaller and less distinctly organized.) The mesoderm somatic mesoderm comprising each somite differentiates into three notochord regions: endoderm aorta — dermatome (lateral) which migrates to form dermis of the skin coelom — sclerotome (medial) forms most of the splanchnic mesoderm axial skeleton (vertebrae, ribs, and base of the skull). Mesoderm Regions — myotome (middle) forms skeletal mus- culature. Individual adult muscles are produced by merger of adjacent myotomes. Note: Nerves make early connections with adjacent myotomes and dermatomes, establishing a segmental innervation pattern. As myotome/dermatome cells migrate to assume adult positions, the segmental nerve supply must follow along to maintain its connection to the innervation target. (Recurrent laryngeal & phrenic nerves travel long distances because their targets migrated far away.) Skin. Consists of dermis and epidermis. Epidermis, including hair follicles & glands, is derived from ectoderm. Neural crest cells migrate into epidermis and become melanocytes. (Other neural crest cells become tactile disc receptors.) Dermis arises from mesoderm (dermatomes of somites). Each dermatome forms a continu- ous area of skin innervated by one spinal nerve. Because adjacent dermatomes overlap, a locus of adult skin is formed by 2 or 3 dermatomes, and innervated by 2 or 3 spinal nerves. Muscle. Muscles develop from mesoderm, except for muscles of the iris which arise from optic cup ectoderm. Cardiac and smooth muscles originate from splanchnic mesoderm. -
A Regulator of Epiphyseal Plate Chondrocyte Proliferation, Hypertrophy, and Long Bone Growth
CHARACTERIZING AQP9: A REGULATOR OF EPIPHYSEAL PLATE CHONDROCYTE PROLIFERATION, HYPERTROPHY, AND LONG BONE GROWTH by Pontius Pu Tian Tang A thesis submitted in conformity with the requirements for the degree of Master of Science Institute of Medical Science University of Toronto © Copyright by Pontius Pu Tian Tang (2018) ii Abstract Characterizing Aqp9: a regulator of epiphyseal plate chondrocyte proliferation, hypertrophy, and long bone growth Pontius Pu Tian Tang Master of Science Institute of Medical Science University of Toronto 2018 Aquaporin-9 (AQP9) is a membrane channel protein suspected to regulate growth in the epiphyseal plate. As long bone defects often possess limited non-surgical options, novel factors underlying bone growth must be continuously explored to advance effective treatments. I hypothesized that Aqp9 is an important epiphyseal plate chondrocyte channel regulating the process of endochondral ossification. In this study, Aqp9 -/- mouse long bones compared to wildtype mouse long bones showed a neonatal hindlimb-specific acceleration of growth followed by reduced length in the juvenile age. Analysis of Aqp9 -/- epiphyseal plates and chondrocytes showed an early disposition for proliferation and aversion from hypertrophy, suggesting that Aqp9 may function similarly to genes such as Col10a1 and Mmp13. This study provides insight into chondrocyte membrane channel proteins and their regulation of the growing epiphyseal plate, demonstrating that Aqp9 may be a novel therapeutic target for the non-invasive intervention of leg length discrepancies. iii Acknowledgements I would like to take this opportunity to thank everyone who has helped me throughout my degree. Firstly, I would like to express my gratitude to my supervisor, Dr. -
The Age Order of Epiphyseal Union Around Elbow Joint - a Radiological Study in Vidarbha
International Journal of Recent Trends in Science And Technology, ISSN 2277-2812 E-ISSN 2249-8109, Volume 10, Issue 2, 2014 pp 251-255 The Age Order of Epiphyseal Union around Elbow Joint - A Radiological Study in Vidarbha Nemade K. S.1*, Kamdi N. Y.2, Meshram M. M.3 1Assistant Professor, 2Associate Professor, 3Professor, Department of Anatomy, GMC, Nagpur, Maharashtra, INDIA. *Corresponding Address: [email protected] Research Article Abstract: Age of union of epiphysis is an important objective even by the workers from the various provinces of the method of age determination which is a difficult task for medico- Indian subcontinent ( Lal and Nat 1934 11 ; Pillai 1936 15 ; legal person. However, this age varies with racial, geographic, Galstaun 1937 9; Basu and Basu 1938 3,4 ; Lal and climatic and various other factors. Study of various text books in 12 et al 8 Anatomy and Radiology exhibits a glaring discrepancy as regards Townsend 1939 ; Gupta . 1974 ). Because of the the ages at which the different epiphyses fuse with the respective existence of such racial, geographic and climatic diaphyses in long bones. These variations have suggested need of variations, need for separate standards of ossification for separate standard of ossification for separate regions. This leads us separate regions have been suggested (Loder et al 1993 14 ; to study ages of epiphyseal union around elbow joint, a rarely Koc et al. 2001 10 ; Crowder et al. 2005 6). So, the present studied joint. Study was performed in total 320 healthy subjects work is undertaken as a pilot study to investigate the ages having ages from 13 to 23 years and length of residence in Vidarbh more than 10 years. -
Sesamoid Bone in the Tendon of the Supinator Muscle of Dogs: Incidence and Comparison of Radiographic and Computed Tomographic Features
Sesamoid bone in the tendon of the supinator muscle of dogs: incidence and comparison of radiographic and computed tomographic features Word count: 8473 Manon Dorny Student number: 01609678 Supervisor: Dr. Ingrid Gielen Supervisor: Prof. dr. Wim Van Den Broeck Supervisor: Dr. Aquilino Villamonte Chevalier A dissertation submitted to Ghent University in partial fulfilment of the requirements for the degree of Master of Veterinary Medicine Academic year: 2018 - 2019 Ghent University, its employees and/or students, give no warranty that the information provided in this thesis is accurate or exhaustive, nor that the content of this thesis will not constitute or result in any infringement of third-party rights. Ghent University, its employees and/or students do not accept any liability or responsibility for any use which may be made of the content or information given in the thesis, nor for any reliance which may be placed on any advice or information provided in this thesis. ACKNOWLEDGEMENTS I would like to thank the people that helped me accomplish this thesis and helped me achieve my degree in veterinary science. First of all I would like to thank Dr. Ingrid Gielen, Dr. Aquilino Villamonte Chevalier and Prof. Dr. Wim Van Den Broeck. I thank them all for their time spend in helping me with my research, their useful advice and their endless patience. Without their help, I wouldn’t have been able to accomplish this thesis. Next I would like to thank my family and friends for their continuing support and motivation during the last years of vet school. My parents and partner especially, for all the mental breakdowns they had to endure in periods of exams and deadlines. -
Morphology and Evolution of Sesamoid Elements in Bats (Mammalia: Chiroptera)
Morphology and Evolution of Sesamoid Elements in Bats (Mammalia: Chiroptera) Author(s): http://orcid.org/0000-0002-7292-3256Lucila Inés Amador, Norberto Pedro Giannini, http://orcid.org/0000-0001-8807-7499Nancy B. Simmons and http:// orcid.org/0000-0002-4615-5011Virginia Abdala Source: American Museum Novitates, (3905):1-40. Published By: American Museum of Natural History https://doi.org/10.1206/3905.1 URL: http://www.bioone.org/doi/full/10.1206/3905.1 BioOne (www.bioone.org) is a nonprofit, online aggregation of core research in the biological, ecological, and environmental sciences. BioOne provides a sustainable online platform for over 170 journals and books published by nonprofit societies, associations, museums, institutions, and presses. Your use of this PDF, the BioOne Web site, and all posted and associated content indicates your acceptance of BioOne’s Terms of Use, available at www.bioone.org/page/terms_of_use. Usage of BioOne content is strictly limited to personal, educational, and non-commercial use. Commercial inquiries or rights and permissions requests should be directed to the individual publisher as copyright holder. BioOne sees sustainable scholarly publishing as an inherently collaborative enterprise connecting authors, nonprofit publishers, academic institutions, research libraries, and research funders in the common goal of maximizing access to critical research. AMERICAN MUSEUM NOVITATES Number 3905, 38 pp. August 17, 2018 Morphology and Evolution of Sesamoid Elements in Bats (Mammalia: Chiroptera) LUCILA INÉS AMADOR,1 NORBERTO PEDRO GIANNINI,1, 2, 3 NANCY B. SIMMONS,2 AND VIRGINIA ABDALA4 ABSTRACT Sesamoids are skeletal elements found within a tendon or ligament as it passes around a joint or bony prominence. -
The Histology of Epiphyseal Union in Mammals
J. Anat. (1975), 120, 1, pp. 1-25 With 49 figures Printed in Great Britain The histology of epiphyseal union in mammals R. WHEELER HAINES* Visiting Professor, Department of Anatomy, Royal Free Hospital School of Medicine, London (Accepted 11 November 1974) INTRODUCTION Epiphyseal union may be defined as beginning with the completion of the first mineralized bridge between epiphyseal and diaphyseal bone and ending with the complete disappearance of the cartilaginous epiphyseal plate and its replacement by bone and marrow. The phases have been described by Sidhom & Derry (1931) and many others from radiographs, but histological material showing union in progress is rare, probably because of the rapidity with which union, once begun, comes to completion (Stephenson, 1924; Dawson, 1929). Dawson (1925, 1929) described the histology of 'lapsed union' in rats, where the larger epiphyses at the 'growing ends' of the long bones remain un-united through- out life. He and Becks et al. (1948) also discussed the early and complete type of union found at the distal end of the humerus in the rat. Here a single narrow per- foration pierced the cartilaginous plate near the olecranon fossa and later spread to destroy the whole plate. Lassila (1928) described a different type of union in the metatarsus of the calf, with multiple perforations of the plate. Apart from a few notes on human material (Haines & Mohiuddin, 1960, 1968), nothing else seems to have been published on the histology of union in mammals. In this paper more abundant material from dog and man is presented and will serve as a basis for discussion of the main features of the different types of union.