Bone Markings / Features on Bones
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Module 2 : Anatomy – the Skeleton
Module 2 : Anatomy – The Skeleton In this module you will learn: The functions of the skeletal system The types of bones in the human body The effects of exercise on your bones What happens to the bones as we get older When studying to become a fitness instructor or personal trainer, you will learn all about the anatomy of the human body. Studying the skeleton is one of the foundations of your trade, you will need to know how the body is structured, the names of each bone, types of bones, importance of bone and joint health, detail of the spine and different terms of movement. Without stating the obvious, each of your clients has their own skeleton and you must be fully aware of how this works. This is for many reasons; you are a teacher and must be fully aware of how to prevent injuries, avoid unnecessary stress on the bones and, if qualified, help the client prevent or heal bone and joint related conditions or medical problems. 2.1 Understanding the Skeletal System The skeleton is comprised of 206 different bones that provide 5 main functions: Support mechanism for muscle and tissue Protection for organs Movement with bones, muscles, and joints Storing minerals and blood cells Growth Skeletal System 2.2 Bones are Formed by Ossification Some bones (such as the flat bones of your skull) in the body are formed in a similar stage to connective tissue. The process is known as direct or intramembranous ossification. Other bones are made up of cartilaginous matter, this is developed from future bone in the embryo which then dissolves and is replaced with other bone cells. -
Pg 131 Chondroblast -> Chondrocyte (Lacunae) Firm Ground Substance
Figure 4.8g Connective tissues. Chondroblast ‐> Chondrocyte (Lacunae) Firm ground substance (chondroitin sulfate and water) Collagenous and elastic fibers (g) Cartilage: hyaline No BV or nerves Description: Amorphous but firm Perichondrium (dense irregular) matrix; collagen fibers form an imperceptible network; chondroblasts produce the matrix and when mature (chondrocytes) lie in lacunae. Function: Supports and reinforces; has resilient cushioning properties; resists compressive stress. Location: Forms most of the embryonic skeleton; covers the ends Chondrocyte of long bones in joint cavities; forms in lacuna costal cartilages of the ribs; cartilages of the nose, trachea, and larynx. Matrix Costal Photomicrograph: Hyaline cartilage from the cartilages trachea (750x). Thickness? Metabolism? Copyright © 2010 Pearson Education, Inc. Pg 131 Figure 6.1 The bones and cartilages of the human skeleton. Epiglottis Support Thyroid Larynx Smooth Cartilage in Cartilages in cartilage external ear nose surface Cricoid Trachea Articular Lung Cushions cartilage Cartilage of a joint Cartilage in Costal Intervertebral cartilage disc Respiratory tube cartilages in neck and thorax Pubic Bones of skeleton symphysis Meniscus (padlike Axial skeleton cartilage in Appendicular skeleton knee joint) Cartilages Articular cartilage of a joint Hyaline cartilages Elastic cartilages Fibrocartilages Pg 174 Copyright © 2010 Pearson Education, Inc. Figure 4.8g Connective tissues. (g) Cartilage: hyaline Description: Amorphous but firm matrix; collagen fibers form an imperceptible network; chondroblasts produce the matrix and when mature (chondrocytes) lie in lacunae. Function: Supports and reinforces; has resilient cushioning properties; resists compressive stress. Location: Forms most of the embryonic skeleton; covers the ends Chondrocyte of long bones in joint cavities; forms in lacuna costal cartilages of the ribs; cartilages of the nose, trachea, and larynx. -
GLOSSARY of MEDICAL and ANATOMICAL TERMS
GLOSSARY of MEDICAL and ANATOMICAL TERMS Abbreviations: • A. Arabic • abb. = abbreviation • c. circa = about • F. French • adj. adjective • G. Greek • Ge. German • cf. compare • L. Latin • dim. = diminutive • OF. Old French • ( ) plural form in brackets A-band abb. of anisotropic band G. anisos = unequal + tropos = turning; meaning having not equal properties in every direction; transverse bands in living skeletal muscle which rotate the plane of polarised light, cf. I-band. Abbé, Ernst. 1840-1905. German physicist; mathematical analysis of optics as a basis for constructing better microscopes; devised oil immersion lens; Abbé condenser. absorption L. absorbere = to suck up. acervulus L. = sand, gritty; brain sand (cf. psammoma body). acetylcholine an ester of choline found in many tissue, synapses & neuromuscular junctions, where it is a neural transmitter. acetylcholinesterase enzyme at motor end-plate responsible for rapid destruction of acetylcholine, a neurotransmitter. acidophilic adj. L. acidus = sour + G. philein = to love; affinity for an acidic dye, such as eosin staining cytoplasmic proteins. acinus (-i) L. = a juicy berry, a grape; applied to small, rounded terminal secretory units of compound exocrine glands that have a small lumen (adj. acinar). acrosome G. akron = extremity + soma = body; head of spermatozoon. actin polymer protein filament found in the intracellular cytoskeleton, particularly in the thin (I-) bands of striated muscle. adenohypophysis G. ade = an acorn + hypophyses = an undergrowth; anterior lobe of hypophysis (cf. pituitary). adenoid G. " + -oeides = in form of; in the form of a gland, glandular; the pharyngeal tonsil. adipocyte L. adeps = fat (of an animal) + G. kytos = a container; cells responsible for storage and metabolism of lipids, found in white fat and brown fat. -
The Epiphyseal Plate: Physiology, Anatomy, and Trauma*
3 CE CREDITS CE Article The Epiphyseal Plate: Physiology, Anatomy, and Trauma* ❯❯ Dirsko J. F. von Pfeil, Abstract: This article reviews the development of long bones, the microanatomy and physiology Dr.med.vet, DVM, DACVS, of the growth plate, the closure times and contribution of different growth plates to overall growth, DECVS and the effect of, and prognosis for, traumatic injuries to the growth plate. Details on surgical Veterinary Specialists of Alaska Anchorage, Alaska treatment of growth plate fractures are beyond the scope of this article. ❯❯ Charles E. DeCamp, DVM, MS, DACVS athologic conditions affecting epi foramen. Growth factors and multipotent Michigan State University physeal (growth) plates in imma stem cells support the formation of neo ture animals may result in severe natal bone consisting of a central marrow P 2 orthopedic problems such as limb short cavity surrounded by a thin periosteum. ening, angular limb deformity, or joint The epiphysis is a secondary ossifica incongruity. Understanding growth plate tion center in the hyaline cartilage forming anatomy and physiology enables practic the joint surfaces at the proximal and distal At a Glance ing veterinarians to provide a prognosis ends of the bones. Secondary ossification Bone Formation and assess indications for surgery. Injured centers can appear in the fetus as early Page E1 animals should be closely observed dur as 28 days after conception1 (TABLE 1). Anatomy of the Growth ing the period of rapid growth. Growth of the epiphysis arises from two Plate areas: (1) the vascular reserve zone car Page E2 Bone Formation tilage, which is responsible for growth of Physiology of the Growth Bone is formed by transformation of con the epiphysis toward the joint, and (2) the Plate nective tissue (intramembranous ossifica epiphyseal plate, which is responsible for Page E4 tion) and replacement of a cartilaginous growth in bone length.3 The epiphyseal 1 Growth Plate Closure model (endochondral ossification). -
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Cartilage Development and Maturation In Vitro and In Vivo Johnathan Ng Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Graduate School of Arts and Sciences Columbia University 2017 © 2017 Johnathan Ng All rights reserved Abstract Cartilage Development and Maturation In Vitro and In Vivo Johnathan Ng The articular cartilage has a limited capacity to regenerate. Cartilage lesions often result in degeneration, leading to osteoarthritis. Current treatments are mostly palliative and reparative, and fail to restore cartilage function in the long term due to the replacement of hyaline cartilage with fibrocartilage. Although a stem-cell based approach towards regenerating the articular cartilage is attractive, cartilage generated from human mesenchymal stem cells (hMSCs) often lack the function, organization and stability of the native cartilage. Thus, there is a need to develop effective methods to engineer physiologic cartilage tissues from hMSCs in vitro and assess their outcomes in vivo. This dissertation focused on three coordinated aims: establish a simple in vivo model for studying the maturation of osteochondral tissues by showing that subcutaneous implantation in a mouse recapitulates native endochondral ossification (Aim 1), (ii) develop a robust method for engineering physiologic cartilage discs from self-assembling hMSCs (Aim 2), and (iii) improve the organization and stability of cartilage discs by implementing spatiotemporal control during induction in vitro (Aim 3). First, the usefulness of subcutaneous implantation in mice for studying the development and maintenance of osteochondral tissues in vivo was determined. By studying juvenile bovine osteochondral tissues, similarities in the profiles of endochondral ossification between the native and ectopic processes were observed. -
Bones of the Skeletal System
BIOLOGY 211: HUMAN ANATOMY & PHYSIOLOGY ********************************************************************************************************* BONES OF THE SKELETAL SYSTEM ********************************************************************************************************** Reference: Saladin, KS: Anatomy & Physiology, The Unity of Form and Function, 6th ed. (2012) or 7th ed. (2015) Please review Chapters 7 & 8 before beginning this lab. INTRODUCTION The skeletal system has a number of important functions in the human body. It is the framework around which the body is organized, it provides levers for muscles to pull against, and it surrounds and protects many soft organs. Equally important, bones serve as a "buffer" in which calcium and other ions can be deposited and withdrawn according to the changing needs of the body, and they are the site of almost all blood cell production. Contrary to our popular conceptions, bones are not rigid, inflexible structures: they are constantly changing, and can have a remarkable degree of flexibility before they break. The organs of the skeletal system are the bones and joints, and like all organs are composed of different types of tissue. Although we tend to classify them into "types" such as "long bones", "flat bones", etc., each is in fact unique and ideally suited to its particular location and function. We classify bones as belonging to either: a) the axial skeleton (head and trunk) b) the appendicular skeleton (arms and legs), However, you should always bear in mind that the entire skeletal system functions as a unit. If you look at any bone, you will see that it is rarely flat or smooth. Bones have a variety of bumps, grooves, holes, etc. which allow them to serve their specific functions. -
Bone Cartilage Dense Fibrous CT (Tendons & Nonelastic Ligaments) Dense Elastic CT (Elastic Ligaments)
Chapter 6 Content Review Questions 1-8 1. The skeletal system consists of what connective tissues? Bone Cartilage Dense fibrous CT (tendons & nonelastic ligaments) Dense elastic CT (elastic ligaments) List the functions of these tissues. Bone: supports the body, protects internal organs, provides levers on which muscles act, store minerals, and produce blood cells. Cartilage provides a model for bone formation and growth, provides a smooth cushion between adjacent bones, and provides firm, flexible support. Tendons attach muscles to bones and ligaments attach bone to bone. 2. Name the major types of fibers and molecules found in the extracellular matrix of the skeletal system. Collagen Proteoglycans Hydroxyapatite Water Minerals How do they contribute to the functions of tendons, ligaments, cartilage and bones? The collagen fibers of tendons and ligaments make these structures very tough, like ropes or cables. Collagen makes cartilage tough, whereas the water-filled proteoglycans make it smooth and resistant. As a result, cartilage is relatively rigid, but springs back to its original shape if it is bent or slightly compressed, and it is an excellent shock absorber. The extracellular matrix of bone contains collagen and minerals, including calcium and phosphate. Collagen is a tough, ropelike protein, which lends flexible strength to the bone. The mineral component gives the bone compression (weight-bearing) strength. Most of the mineral in the bone is in the form of hydroxyapatite. 3. Define the terms diaphysis, epiphysis, epiphyseal plate, medullary cavity, articular cartilage, periosteum, and endosteum. Diaphysis – the central shaft of a long bone. Epiphysis – the ends of a long bone. Epiphyseal plate – the site of growth in bone length, found between each epiphysis and diaphysis of a long bone and composed of cartilage. -
BONE LANDMARKS Vocabulary to Learn: Bone Structures Attachments
BONE LANDMARKS ✔ Vocabulary to learn: Attachments for Articulation Depressions Bone structures tendons or projections and openings ligaments Articular cartilage Crest Condyle Fissure Compact bone Epicondyle Facet Foramen Diaphysis Line Head Fossa Endosteum Process Ramus Groove Epiphyseal line Spine Meatus Epiphysis Trochanter Nutrient foramen Medullary cavity Tubercle Sinus Neck Tuberosity Sulcus Periosteum Spongy bone Trabeculae ✔ Complete the following statements with the most appropriate term: On the external surface and most of the diaphysis, the superficial structure of the bone is dense or ________________________ bone, whereas internally and deep in the epiphyses, the bone is open or ________________________ bone and consists of ________________________, which are a fine meshwork of "flying buttresses" to give the bone strength. The tubular shaft of the bone is called the ________________________ which in some cases contains a medullary cavity. The extremity of the bone is called the ________________________ and it is distally covered by a thin layer of ________________________. Bone is covered by a dense connective tissue called ________________________. A narrowed portion of a bone at the base of the head of the bone is the ________________________. A moderately raised ridge along a bone for attaching muscles is a ________________________ or line. A sharp, slender pointed projection (like the point of a pencil) is a ________________________ and is the site of attachment for muscles or ligaments. Any bony projection or bump can be generically called a _______________________. A shallow depression in a bone is called a ________________________. Openings in a bone, for passage of a nerve or vessel, that are round or oval are referred to as ________________________ , ________________________ if they are narrow or slit-like, and a ________________________ if they are canal-like. -
Compact Bone Spongy Bone
Spongy bone Compact bone © 2018 Pearson Education, Inc. 1 (b) Flat bone (sternum) (a) Long bone (humerus) (d) Irregular bone (vertebra), right lateral view (c) Short bone (talus) © 2018 Pearson Education, Inc. 2 Articular cartilage Proximal epiphysis Spongy bone Epiphyseal line Periosteum Compact bone Medullary cavity (lined by endosteum) Diaphysis Distal epiphysis (a) © 2018 Pearson Education, Inc. 3 Trabeculae of spongy bone Osteon (Haversian Perforating system) (Volkmann’s) canal Blood vessel continues into medullary cavity containing marrow Blood vessel Lamellae Compact bone Central (Haversian) canal Perforating (Sharpey’s) fibers Periosteum Periosteal blood vessel (a) © 2018 Pearson Education, Inc. 4 Lamella Osteocyte Canaliculus Lacuna Central Bone matrix (Haversian) canal (b) © 2018 Pearson Education, Inc. 5 Osteon Interstitial lamellae Lacuna Central (Haversian) canal (c) © 2018 Pearson Education, Inc. 6 Articular cartilage Hyaline Spongy cartilage bone New center of bone growth New bone Epiphyseal forming plate cartilage Growth Medullary in bone cavity width Bone starting Invading to replace Growth blood cartilage in bone vessels length New bone Bone collar forming Hyaline Epiphyseal cartilage plate cartilage model In an embryo In a fetus In a child © 2018 Pearson Education, Inc. 7 Bone growth Bone grows in length because: Articular cartilage 1 Cartilage grows here. Epiphyseal plate 2 Cartilage is replaced by bone here. 3 Cartilage grows here. © 2018 Pearson Education, Inc. 8 Bone remodeling Growing shaft is remodeled as: Articular cartilage Epiphyseal plate 1 Bone is resorbed by osteoclasts here. 2 Bone is added (appositional growth) by osteoblasts here. 3 Bone is resorbed by osteoclasts here. © 2018 Pearson Education, Inc. 9 Hematoma External Bony callus callus of spongy bone New Internal blood callus vessels Healed (fibrous fracture tissue and Spongy cartilage) bone trabecula 1 Hematoma 2 Fibrocartilage 3 Bony callus 4 Bone remodeling forms. -
The Potential of FGF-2 in Craniofacial Bone Tissue Engineering: a Review
cells Review The Potential of FGF-2 in Craniofacial Bone Tissue Engineering: A Review Anita Novais 1,2, Eirini Chatzopoulou 1,2,3, Catherine Chaussain 1,2 and Caroline Gorin 1,2,* 1 Pathologies, Imagerie et Biothérapies Orofaciales, Université de Paris, URP2496, 1 rue Maurice Arnoux, 92120 Montrouge, France; [email protected] (A.N.); [email protected] (E.C.); [email protected] (C.C.) 2 AP-HP Département d’Odontologie, Services d’odontologie, GH Pitié Salpêtrière, Henri Mondor, Paris Nord, Hôpital Rothschild, Paris, France 3 Département de Parodontologie, Université de Paris, UFR Odontologie-Garancière, 75006 Paris, France * Correspondence: [email protected]; Tel./Fax: +33-(0)1-5807-6724 Abstract: Bone is a hard-vascularized tissue, which renews itself continuously to adapt to the mechanical and metabolic demands of the body. The craniofacial area is prone to trauma and pathologies that often result in large bone damage, these leading to both aesthetic and functional complications for patients. The “gold standard” for treating these large defects is autologous bone grafting, which has some drawbacks including the requirement for a second surgical site with quantity of bone limitations, pain and other surgical complications. Indeed, tissue engineering combining a biomaterial with the appropriate cells and molecules of interest would allow a new therapeutic approach to treat large bone defects while avoiding complications associated with a second surgical site. This review first outlines the current knowledge of bone remodeling and the different signaling pathways involved seeking to improve our understanding of the roles of each to be able to stimulate or inhibit them. -
Aandp1ch07lecture.Pdf
Chapter 07 Lecture Outline See separate PowerPoint slides for all figures and tables pre- inserted into PowerPoint without notes. Copyright © McGraw-Hill Education. Permission required for reproduction or display. 1 Introduction • In this chapter we will cover: – Bone tissue composition – How bone functions, develops, and grows – How bone metabolism is regulated and some of its disorders 7-2 Introduction • Bones and teeth are the most durable remains of a once-living body • Living skeleton is made of dynamic tissues, full of cells, permeated with nerves and blood vessels • Continually remodels itself and interacts with other organ systems of the body • Osteology is the study of bone 7-3 Tissues and Organs of the Skeletal System • Expected Learning Outcomes – Name the tissues and organs that compose the skeletal system. – State several functions of the skeletal system. – Distinguish between bones as a tissue and as an organ. – Describe the four types of bones classified by shape. – Describe the general features of a long bone and a flat bone. 7-4 Tissues and Organs of the Skeletal System • Skeletal system—composed of bones, cartilages, and ligaments – Cartilage—forerunner of most bones • Covers many joint surfaces of mature bone – Ligaments—hold bones together at joints – Tendons—attach muscle to bone 7-5 Functions of the Skeleton • Support—limb bones and vertebrae support body; jaw bones support teeth; some bones support viscera • Protection—of brain, spinal cord, heart, lungs, and more • Movement—limb movements, breathing, and other -
The Importance of Vascular System in Long Bone Is Far from Well Known
ogy: iol Cu ys r h re P n t & R y e s Anatomy & Physiology: Current Fei and Gu, Anat Physiol 2012, 2:5 m e o a t r a c DOI: 10.4172/2161-0940.1000e121 n h A Research ISSN: 2161-0940 Editorial Open Access The Importance of Vascular System in Long Bone is Far from Well Known Jia Fei1* and WeiKuan Gu2 1Department of Physiology and Pharmacology, University of Georgia, USA 2Department of Orthopedic Surgery & BME, Campbell-Clinic, University of Tennessee Health Science Center, Memphis, Tennessee, USA The long bones, including the femur and tibia, are not only essential known very well. More study on bone-vessel interaction is needed to for locomotion and mechanical support, but also critical for managing better understand the mechanism of fracture, osteoporosis, and tumor calcium balance and supporting hematopoiesis. In order to be involved metastasis. in these missions, vascular system in bone has evolved to a specific References structure [1]. 1. Schatteman GC, Awad O (2004) Hemangioblasts, angioblasts, and adult The Role of Vessel in Bone Property endothelial cell progenitors. Anat Rec A Discov Mol Cell Evol Biol 276: 13-21. 2. Pugsley MK, Tabrizchi R (2000) The vascular system. An overview of structure The vascular system of bone includes three types of blood supply: and function. J Pharmacol Toxicol Methods 44: 333-340. diaphyseal, epiphyseal, and periosteal vessels. The epiphyseal blood 3. Mahachoklertwattana P, Chuansumrit A, Sirisriro R, Choubtum L, supply is through the capillary system. The periosteal blood supply is Sriphrapradang A, et al. (2003) Bone mineral density, biochemical and derived from intramuscular perifibrillar capillaries and forms the specific hormonal profiles in suboptimally treated children and adolescents with beta- lateral blood vessel pool: cortical capillaries and marrow sinusoid.