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Incidence of Skin Tumors in Dogs in Salvador, Bahia State, Brazil (2007-2016)1 Gessica A.C

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Incidence of Skin Tumors in Dogs in Salvador, Bahia State, Brazil (2007-2016)1 Gessica A.C Pesq. Vet. Bras. 38(11):2139-2145, novembro 2018 DOI: 10.1590/1678-5150-PVB-5686 Original Article Pequenos Animais/Small Animals Diseases ISSN 0100-736X (Print) ISSN 1678-5150 (Online) PVB-5686 SA Incidence of skin tumors in dogs in Salvador, Bahia state, Brazil (2007-2016)1 Gessica A.C. Machado2, Thanielle N. Fontes2, Daniela F. Larangeira3, Alessandra Estrela-Lima3, Eduardo L.T. Moreira3, Lorena S. Ribeiro4, Marcela P.R. Pinto5 and Tiago C. Peixoto3* ABSTRACT.- Machado G.A.C., Fontes T.N., Larangeira D.F., Estrela-Lima A., Moreira E.L.T., Ribeiro L.S., Pinto M.P.R. & Peixoto T.C. 2018. Incidence of skin tumors in dogs in Salvador, Bahia state, Brazil (2007-2016). Pesquisa Veterinária Brasileira 38(11):2139-2145. Departamento de Anatomia, Patologia e Clínicas Veterinárias, Universidade Federal da Bahia, Av. Adhemar de Barros 500, Ondina, Salvador, BA 40170-110, Brazil. E-mail: Incidence of skin tumors in dogs in Salvador, This study aimed to establish the incidence of skin tumors (cutaneous proliferative lesions of neoplastic or non-neoplastic nature) in dogs [email protected] by histopathological Bahia state, Brazil (2007-2016) evaluation at the Veterinary Pathology Laboratory (LPV) of the Federal University of Bahia (UFBA) in a 10-year (2007-2016) historical series. Of the 1945 histopathological diagnoses made in this period, 503 were skin biopsies, and 617 dermatological problems (87 dogs, [Frequência de dermatopatias tumorais em cães da 17.3%, presented more than one positive diagnosis) were found. Of the 617 diagnoses of cidade de Salvador, Bahia (2007-2016)]. dermatopathy, 546 (88.49%) were tumors and 71 (11.51%) were non-tumorous alterations. The 546 conditions more profoundly studied were from 453 dogs, 468 (85.7%) neoplastic Machado G.A.C., Fontes T.N., Larangeira D.F., Estrela- Lima A., Moreira E.L.T., Ribeiro L.S., Pinto M.P.R. & 230 benign (49.14%), 215 malignant (45.94%), 23 borderline (epitheliomas) (4.91%), 51.92% Peixoto T.C. 2139- and(243/468) 78 (14.3%) mesenchymal, non-neoplastic 42.74% tumors. (200/468) The epithelial, 468 neoplasms 4.91% were(23/468) classified melanocytic, as follows: and 2145 0.43% (2/468) metastatic (mammary gland). The most commonly diagnosed neoplastic dermatopathies were mastocytoma (14.7%) and lipoma (7.48%). Among the 78 non-neoplastic conditions (14.3%), epidermal inclusion cyst (39.74%) and trichogranuloma (15.38%) LPV-UFBA. Distinct simultaneous dermatological problems were frequently found in the dogs wereassessed the most(one infrequent. six). Considering Canine dermatopathies that these conditions accounted can for present 26% of with the biopsydifferent files cellular of the origin and biological behavior, it is crucial that histopathological evaluation be performed in fragments from the different cutaneous lesions. INDEX TERMS: Skin tumors, dogs, Bahia state, dermatology, dermatopathology, cutaneous neoplasms, pathology. RESUMO.- [Frequência de dermatopatias tumorais dermatopatias tumorais (lesões proliferativas cutâneas que em cães da cidade de Salvador, Bahia (2007-2016).] cursam com aumento de volume de natureza neoplásicas Objetivou-se com esse estudo determinar a frequência de ou não neoplásicas) em cães, diagnosticadas por exame histopatológico no Laboratório de Patologia Veterinária (LPV) 1 Received on June 11, 2018. da Universidade Federal da Bahia (UFBA) na série histórica Accepted for publication on July 17, 2018. de 10 anos (2007-2016). Dos 1.945 exames histopatológicos realizados no período, 503 tratava-se de biópsias cutâneas, 2 Post-Graduate Program in Tropical Animal Science (PPGCAT), Escola de dentre os quais, foram diagnosticados 617 dermatopatias Part of the MSc Dissertation of the first author, Universidade Federal do Bahia. Medicina Veterinária e Zootecnia (EMEVZ), Universidade Federal da Bahia (87 cães, 17,3%, apresentavam mais de um diagnóstico). (UFBA), Salvador, BA 40170-110, Brazil. Dos 617 diagnósticos de dermatopatias 546 (88,49%) foram 3 Departamento de Anatomia, Patologia e Clínicas Veterinárias, Escola de Medicina Veterinária e Zootecnia (EMEVZ), Universidade Federal da Bahia tumorais e 71 (11,51%) não tumorais. As 546 dermatopatias (UFBA), Salvador, BA 40170-110. *Corresponding author: tumorais, estudadas com mais ênfase, foram diagnosticadas 4 Autonomous Veterinary, Salvador, BA. em 453 cães, 468 (85,7%) eram neoplásicas e 78 (14,3%) [email protected] 5 Resident in Veterinary Pathology, Laboratório de Patologia Veterinária não neoplásicas. Das 468 dermatopatias tumorais neoplásicas (LPV), Escola de Medicina Veterinária e Zootecnia (EMEVZ), Universidade encontradas 230 foram benignas (49,14%), 215 malignas Federal da Bahia (UFBA), Salvador, BA 40170-110. (45,94%), 23 borderline/epiteliomas (4,91%), 51,92% 2139 2140 Gessica A.C. Machado et al. (243/468) de origem mesenquimal, 42,74% (200/468) MATERIALS AND METHODS epiteliais, 4,91% (23/468) melanocíticas e 0,43% (2/468) This study was conducted at the Laboratory of Veterinary Pathology metastáticas para a pele (primárias de glândula mamária). (LPV) of the Federal University of Bahia (UFBA). All skin biopsy As dermatopatias neoplásicas mais diagnosticadas foram protocols (requests and histopathological reports) of dogs with a o mastocitoma (14,7%) e o lipoma (7,48%). Dentre as conclusive diagnosis of neoplastic and non-neoplastic dermatopathies 78 dermatopatias tumorais não neoplásicas (14,3%), os (inclusion criterion) archived at the LPV-UFBA from January 2007 cistos de inclusão epidermal (39,74%) e o tricogranuloma to December 2016 were revised. (15,38%) foram os mais frequentes. As dermatopatias caninas representaram 26% da casuística no LPV/UFBA. A ocorrência de dermatopatias tumorais simultâneas distintas foi comum collectedData fromon breed, the biopsy sex, agereports (pups, revised ≤1 year; in this adults, study. Reproductive>1 year and nos cães desse estudo (um a cada seis); como podem ter origens status≤8 years; (sexually elderly, intact >8 years) or castrated) and histopathological was not included diagnosis in this survey were celulares e comportamentos biológicos diferentes, enfatiza-se because many reports did not present this information. a importância da coleta e envio para exame histopatológico Data on anatomical location of the tumor lesions were analyzed de fragmentos das diferentes lesões cutâneas. and the distribution proposed by Goldschmidt & Shofer (1992) was used. Dogs that presented more than one tumor lesion with the same TERMOS DE INDEXAÇÃO: Dermatopatias, tumores, caninos, Salvador, microscopic diagnosis were considered as of multicentric anatomical Bahia, dermatologia, dermatopatologia, neoplasias cutâneas, patologia. distribution, whereas dogs that showed more than one skin tumor (multiple tumors) at histopathological diagnosis were analyzed and INTRODUCTION included in the survey individually within each category. Skin diseases are often diagnosed in domestic animals (Balda et al. borderline (group composed of epitheliomas) according to biological 2004), accounting for 20-75% of the cases in routine small behavior,Cutaneous and into neoplasms epithelial, were mesenchymal, classified intoand melanocyticbenign, malignant, according or animal general practice (Scott et al. 2001). In dogs and cats, tumor diseases can be neoplastic or non-neoplastic in nature, & Wilcock (1994) and Gross et al. (2009). Tumor-like lesions were such as cysts, nodular hyperplasia, and hamartomas, that to origin and characteristic of cells, based on the classifications by Yager is, the term skin tumor is generically used for proliferative lesions that occur with increased cutaneous volume. There is classifiedNon-neoplastic as non-neoplastic proliferations proliferative were and analyzed neoplastic separately lesions of and the a wide variety of tumoral and non-tumoral dermatopathies primary mammary glands were classified as metastatic to the skin. with similar clinical manifestation or macroscopic appearance. This fact underscores the importance of performing a correct pyoderma,classified microscopically trichogranuloma, as cysts, and nodular hyperplasia, cutaneous amyloidosis, acrocordon, diagnostic investigation. Therefore, veterinarians need to basedfibroanal on theand terminology collagenous proposedhamartoma, by organizedGross et al. hematoma, (2009). Because callus know the main diseases that affect animals in their region. this is a 10-year retrospective study, it should be noted that changes In some situations, histopathological examination can establish in the nomenclature of some skin tumors have occurred during this period; therefore, in order to standardize and compile the results exclusion of differential diagnoses. In addition, close contact adequately, old nomenclatures were replaced with their current abetween definitive pathologists diagnosis and or, clinical at least, dermatologists assist clinicians is fundamental, with the corresponding terms according to Gross et al. (2009). as it enables discussion of the cases and, when necessary, The annual activity reports of the LPV-UFBA were also revised from accomplishment of histochemical or immunohistochemical 2007 to 2016 aiming to obtain data on the cases of histopathological biopsy examinations in animals of the canine species. This study was It is thus evident that the study of the major skin diseases conducted following the norms of animal use and experimentation techniquesthat affect dogs to confirm becomes or exclude increasingly a suspicion important (Scott for et clinicians al. 2001). and was approved
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