DOCSLIB.ORG

Evidenzbericht: S3-Leitlinie „Adulte Weichgewebesarkome“

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Evidenzbericht: S3-Leitlinie „Adulte Weichgewebesarkome“ Institut für Forschung in der Operativen Medizin (IFOM) Evidenzbericht: S3-Leitlinie „Adulte Weichgewebesarkome“ IFOM - Institut für Forschung in der Operativen Medizin (Universität Witten/Herdecke) Jessica Breuing, Tim Mathes, Katharina Doni, Tanja Rombey, Barbara Prediger, Dawid Pieper Datum: 03.07.2020 Kontakt: Jessica Breuing IFOM - Institut für Forschung in der Operativen Medizin Univ.-Prof. Dr. Rolf Lefering Fakultät für Gesundheit, Department für Humanmedizin Universität Witten/Herdecke Ostmerheimer Str. 200, Haus 38 51109 Köln Tel.: 0221 98957-41 Fax: 0221 98957-30 Dr. Tim Mathes IFOM - Institut für Forschung in der Operativen Medizin Univ.-Prof. Dr. Rolf Lefering Fakultät für Gesundheit, Department für Humanmedizin Universität Witten/Herdecke Ostmerheimer Str. 200, Haus 38 51109 Köln Tel.: 0221 98957-43 Fax: 0221 98957-30 Inhalt 1. Literaturrecherche ........................................................................................................................ 5 1.1. Einschlusskriterien Systemtherapie ....................................................................................... 5 1.1.1. Neoadjuvante Systemtherapie (+ GIST) ........................................................................ 5 1.1.2. Adjuvante Systemtherapie (+ GIST) ............................................................................... 5 1.1.3. Therapie der metastasierten Erkrankung (+ GIST) ...................................................... 6 1.2. Einschlusskriterien Chirurgie ................................................................................................... 6 1.2.1. Ablation ............................................................................................................................... 6 1.2.2. Hyperthermie ...................................................................................................................... 6 1.2.3. OP ........................................................................................................................................ 7 1.2.4. Resektionsränder ............................................................................................................... 7 1.2.5. Strahlentherapie ................................................................................................................. 8 1.3. Einschlusskriterien Rehabilitation ........................................................................................... 8 1.4. Einschlusskriterien Psychoonkologie ..................................................................................... 8 1.5. Datenquellen und Suchstrategie ............................................................................................ 9 1.5.1. Recherchestrategie Systemtherapie .............................................................................. 9 1.5.2. Recherchestrategie Systemtherapie-GIST .................................................................. 12 1.5.3. Recherchestrategie Systemtherapie-GIST (adjuvante Imatinibtherapie) ............... 12 1.5.4. Recherchestrategie Chirurgie-Ablation ........................................................................ 13 1.5.5. Recherchestrategie Chirurgie-Hyperthermie ............................................................... 17 1.5.6. Recherchestrategie Chirurgie-OP ................................................................................. 19 1.5.7. Recherchestrategie Chirurgie-Resektionsränder ....................................................... 21 1.5.8. Recherchestrategie Chirurgie-Strahlentherapie ......................................................... 24 1.5.9. Recherchestrategie Rehabilitation ................................................................................ 26 1.5.10. Recherchestrategie Psychoonkologie ........................................................................ 28 1.6. Studienselektion ...................................................................................................................... 31 2. Bewertung des Vertrauens in die Evidenz gemäß GRADE................................................. 31 3. Studienbewertung (Bewertung des Risikos für systematische Verzerrung) ..................... 32 4. Datenextraktion und Durchführung von Metaanalysen ........................................................ 32 5. Ergebnisse der Literaturrecherche .......................................................................................... 33 6. Appendix ...................................................................................................................................... 39 Appendix A: Level of Evidence nach GRADE ............................................................................ 39 Appendix B: Cochrane Risk of Bias ............................................................................................. 40 Appendix C: Newcastle-Ottawa Quality Assessment Scale (NOS) ........................................ 41 2 Appendix D: Liste der ausgeschlossenen Studien mit Gründen ............................................. 42 Referenzen .......................................................................................................................................... 64 3 Abbildungsverzeichnis Abbildung 1: Flowchart Systemtherapie.......................................................................................... 34 Abbildung 2: Flowchart Systemtherapie-GIST ............................................................................... 34 Abbildung 3: Flowchart Systemtherapie-GIST (adjuvante Imatinibtherapie) ............................ 35 Abbildung 4: Flowchart Chirurgie-Ablation ..................................................................................... 35 Abbildung 5: Flowchart Chirurgie-Hyperthermie ............................................................................ 36 Abbildung 6: Flowchart Chirurgie-OP .............................................................................................. 36 Abbildung 7: Flowchart Chirurgie-Resektionsränder..................................................................... 37 Abbildung 8: Flowchart Chirurgie-Strahlentherapie ...................................................................... 37 Abbildung 9: Flowchart Rehabilitation ............................................................................................. 38 Abbildung 10: Flowchart Psychoonkologie ..................................................................................... 38 Tabellenverzeichnis Tabelle 1: Einschlusskriterien neoadjuvante Systemtherapie ....................................................... 5 Tabelle 2: Einschlusskriterien adjuvante Systemtherapie .............................................................. 5 Tabelle 3: Einschlusskriterien adjuvante Imatinibtherapie ............................................................. 5 Tabelle 4: Einschlusskriterien Therapie der metastasierten Erkrankung ..................................... 6 Tabelle 5: Einschlusskriterien Ablation.............................................................................................. 6 Tabelle 6: Einschlusskriterien Hyperthermie .................................................................................... 6 Tabelle 7: Einschlusskriterien OP ...................................................................................................... 7 Tabelle 8: Einschlusskriterien Resektionsränder ............................................................................. 7 Tabelle 9: Einschlusskriterien Strahlentherapie ............................................................................... 8 Tabelle 10: Einschlusskriterien Rehabilitation .................................................................................. 8 Tabelle 11: Einschlusskriterien Psychoonkologie ............................................................................ 8 Tabelle 12: Suchstrategie Systemtherapie ....................................................................................... 9 Tabelle 13: Suchstrategie Systemtherapie-GIST .......................................................................... 12 Tabelle 14: Suchstrategie Systemtherapie-GIST (adjuvante Imatinibtherapie) ........................ 12 Tabelle 15: Suchstrategie Chirurgie-Ablation ................................................................................. 13 Tabelle 16: Suchstrategie Chirurgie-Hyperthermie ....................................................................... 17 Tabelle 17: Suchstrategie Chirurgie-OP ......................................................................................... 19 Tabelle 18: Suchstrategie Chirurgie-Resektionsränder ................................................................ 21 Tabelle 19: Suchstrategie Chirurgie-Strahlentherapie .................................................................. 24 Tabelle 20: Suchstrategie Rehabilitation ........................................................................................ 26 Tabelle 21: Suchstrategie Psychoonkologie .................................................................................. 28 4 Institut für Forschung in der Operativen Medizin (IFOM) 1. Literaturrecherche Im Rahmen der S3-Leitlinie „Adulte Weichgewebesarkome“ wurden insgesamt vier Recher- cheaufträge (Systemtherapie, Chirurgie, Rehabilitation und Psychoonkologie) durchgeführt. Diese sind im Fall der Systemtherapie und der Chirurgie noch in weitere Subthemen unter- teilt. Der Rechercheauftrag Systemtherapie hat insgesamt drei
Load more

Recommended publications
  • Heart Tumors in Domestic Animals
    HEART TUMORS IN DOMESTIC ANIMALS Marko Hohšteter Department of veterinary pathology, Veterinary Faculty University of Zagreb Neoplasms of the heart are rare diseases in domestic animals. Among all domestic animals heart neoplasm are most common in dogs. Most of the canine heart tumors are primary what is contrary to other domestic animals, in which most of cardiac tumors are metastatic. Primary tumors of the heart represent 0,69% of the canine tumors. Among all primary neoplasms canine hemangiosarcoma of the right atrium is the most common. Other primary cardiac tumors in domestic animals include rhabdomyoma, rhabdomyosarcoma, myxoma, myxosarcoma, chondrosarcoma, osteosarcoma, granular cell tumor, fibroma, fibrosarcoma, lipoma, pericardial mesothelioma and undifferentiated sarcoma. Aortic and carotid body tumors are usually classified under primary heart neoplasm but are actually tumors which arise in adventitia or periarterial adipose tissue of the aorta, carotid artery or pulmonary artery, and can extend to heart base. Hemangiosarcoma is the most important and most frequent cardiac neoplasm of dogs. This tumor develops primary from the blood vessels that line the heart or can matastasize from sites such as spleen, skin or liver. It is most commonly reported in mid to large breeds, such as boxers, German shepherds, golden retrievers, and in older dogs (six years and older). Aortic and carotide body adenoma and adenocarcinoma belong into the group of chemoreceptor tumors („chemodectomas“) and are morphologicaly similar. In animals, incidence of aortic body neoplasm is higher than that of the carotide body. Both tumors mostly develop in dogs (brachyocephalic breed: boxers, Boston teriers), and are rare in cats and cattle.
    [Show full text]
  • PROPOSED REGULATION of the STATE BOARD of HEALTH LCB File No. R057-16
    PROPOSED REGULATION OF THE STATE BOARD OF HEALTH LCB File No. R057-16 Section 1. Chapter 457 of NAC is hereby amended by adding thereto the following provision: 1. The Division may impose an administrative penalty of $5,000 against any person or organization who is responsible for reporting information on cancer who violates the provisions of NRS 457. 230 and 457.250. 2. The Division shall give notice in the manner set forth in NAC 439.345 before imposing any administrative penalty 3. Any person or organization upon whom the Division imposes an administrative penalty pursuant to this section may appeal the action pursuant to the procedures set forth in NAC 439.300 to 439. 395, inclusive. Section 2. NAC 457.010 is here by amended to read as follows: As used in NAC 457.010 to 457.150, inclusive, unless the context otherwise requires: 1. “Cancer” has the meaning ascribed to it in NRS 457.020. 2. “Division” means the Division of Public and Behavioral Health of the Department of Health and Human Services. 3. “Health care facility” has the meaning ascribed to it in NRS 457.020. 4. “[Malignant neoplasm” means a virulent or potentially virulent tumor, regardless of the tissue of origin. [4] “Medical laboratory” has the meaning ascribed to it in NRS 652.060. 5. “Neoplasm” means a virulent or potentially virulent tumor, regardless of the tissue of origin. 6. “[Physician] Provider of health care” means a [physician] provider of health care licensed pursuant to chapter [630 or 633] 629.031 of NRS. 7. “Registry” means the office in which the Chief Medical Officer conducts the program for reporting information on cancer and maintains records containing that information.
    [Show full text]
  • Partners in Care – January 2017
    The newSEE CE Schedule INSIDE & on a Referralremovable Contact postcard! Info Partners In Care Veterinary Referral News from Angell Animal Medical Center Winter 2017 π Volume 11:1 π angell.org π facebook.com/AngellReferringVeterinarians PRE-HOSPITAL EYELID MARGIN SEDATION OPTIONS BUILDING A RADIOGRAPHIC TUMOR GRADING— MASSES IN DOGS: FOR AGGRESSIVE AND CONFIDENT PUPPY APPROACH TO IS IT APPLICABLE? TO CUT OR ANXIOUS DOGS BONE IMAGING NOT TO CUT? PAGE 1 PAGE 1 PAGE 4 PAGE 6 PAGE 8 ANESTHESIA BEHAVIOR Pre-Hospital Sedation Building a Options for Aggressive Confident Puppy and Anxious Dogs π Terri Bright, Ph.D., BCBA-D, CAAB π Kate Cummings, DVM, DACVAA angell.org/behavior [email protected] angell.org/anesthesia 617-989-1520 [email protected] 617-541-5048 ggressive and/or fearful dogs present several challenges for the othing makes everyone happier than having puppies in the small animal practitioner. These patients are difficult to fully veterinary office. The client brings the pup soon after they evaluate and present a safety hazard to the clinic staff, purchase or adopt it to make sure it is healthy, and to begin the veterinarian, and sometimes even the owner. In addition, a process of vaccinations and a lifetime of health. Everyone oohs Anervous dog contributes to heightened stress within the work area affecting Nand ahs over it, but what are the most important things a vet and their staff not only people, but other pets alike. In dogs known to be aggressive within can do to make sure the pup grows up to be happy and behaviorally healthy? the hospital setting or those with tremendous fear/anxiety, making physical exams and basic assessment impossible, pre-hospital sedation can First, find out what the puppy’s history is.
    [Show full text]
  • New Jersey State Cancer Registry List of Reportable Diseases and Conditions Effective Date March 10, 2011; Revised March 2019
    New Jersey State Cancer Registry List of reportable diseases and conditions Effective date March 10, 2011; Revised March 2019 General Rules for Reportability (a) If a diagnosis includes any of the following words, every New Jersey health care facility, physician, dentist, other health care provider or independent clinical laboratory shall report the case to the Department in accordance with the provisions of N.J.A.C. 8:57A. Cancer; Carcinoma; Adenocarcinoma; Carcinoid tumor; Leukemia; Lymphoma; Malignant; and/or Sarcoma (b) Every New Jersey health care facility, physician, dentist, other health care provider or independent clinical laboratory shall report any case having a diagnosis listed at (g) below and which contains any of the following terms in the final diagnosis to the Department in accordance with the provisions of N.J.A.C. 8:57A. Apparent(ly); Appears; Compatible/Compatible with; Consistent with; Favors; Malignant appearing; Most likely; Presumed; Probable; Suspect(ed); Suspicious (for); and/or Typical (of) (c) Basal cell carcinomas and squamous cell carcinomas of the skin are NOT reportable, except when they are diagnosed in the labia, clitoris, vulva, prepuce, penis or scrotum. (d) Carcinoma in situ of the cervix and/or cervical squamous intraepithelial neoplasia III (CIN III) are NOT reportable. (e) Insofar as soft tissue tumors can arise in almost any body site, the primary site of the soft tissue tumor shall also be examined for any questionable neoplasm. NJSCR REPORTABILITY LIST – 2019 1 (f) If any uncertainty regarding the reporting of a particular case exists, the health care facility, physician, dentist, other health care provider or independent clinical laboratory shall contact the Department for guidance at (609) 633‐0500 or view information on the following website http://www.nj.gov/health/ces/njscr.shtml.
    [Show full text]
  • Bone and Soft Tissue Sarcomas
    Bone and Soft Tissue Sarcomas Changes to Pathology Codes in the 4th Edition of the World Health Organisation Classification of Bone and Soft Tissue Sarcomas September 2013 Page 1 of 17 Authors Mr Matthew Francis Cancer Analysis Development Manager, Public Health England Knowledge & Intelligence Team (West Midlands) Dr Nicola Dennis Sarcoma Analyst, Public Health England Knowledge & Intelligence Team (West Midlands) Ms Jackie Charman Cancer Data Development Analyst Public Health England Knowledge & Intelligence Team (West Midlands) Dr Gill Lawrence Breast and Sarcoma Cancer Analysis Specialist, Public Health England Knowledge & Intelligence Team (West Midlands) Professor Rob Grimer Consultant Orthopaedic Oncologist The Royal Orthopaedic Hospital NHS Foundation Trust For any enquiries regarding the information in this report please contact: Mr Matthew Francis Public Health England Knowledge & Intelligence Team (West Midlands) Public Health Building The University of Birmingham Birmingham B15 2TT Tel: 0121 414 7717 Fax: 0121 414 7712 E-mail: [email protected] Acknowledgements The Public Health England Knowledge & Intelligence Team (West Midlands) would like to thank the following people for their valuable contributions to this report: Dr Chas Mangham Consultant Orthopaedic Pathologist, Robert Jones and Agnes Hunt Orthopaedic and District Hospital NHS Trust Professor Nick Athanasou Professor of Musculoskeletal Pathology, University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences Copyright @ PHE Knowledge & Intelligence Team (West Midlands) 2013 1.0 EXECUTIVE SUMMARY Page 2 of 17 The 4th edition of the World Health Organisation (WHO) Classification of Tumours of Soft Tissue and Bone which was published in 2012 contains notable changes from the 2002 3rd edition. The key differences between the 3rd and 4th editions can be seen in Table 1.
    [Show full text]
  • Canine Myxosarcomas, a Retrospective Analysis of 32 Dogs (2003–2018) Yoshimi Iwaki1* , Stephanie Lindley1, Annette Smith1, Kaitlin M
    Iwaki et al. BMC Veterinary Research (2019) 15:217 https://doi.org/10.1186/s12917-019-1956-z RESEARCH ARTICLE Open Access Canine myxosarcomas, a retrospective analysis of 32 dogs (2003–2018) Yoshimi Iwaki1* , Stephanie Lindley1, Annette Smith1, Kaitlin M. Curran2 and Jayme Looper3 Abstract Background: Myxosarcomas are known to be classified as soft tissue sarcomas. However, there is limited clinical characterization pertaining specifically to canine cutaneous myxosarcomas in the literature. The objective of this study is to evaluate the local recurrence rate, metastatic rate and prognosis of canine myxosarcoma. Results: A total of 32 dogs diagnosed with myxosarcoma via histopathology were included in this retrospective study. All dogs had surgical resection. No adjunct treatments were performed in 9 dogs, while 22 dogs also received either radiation therapy or chemotherapy, or a combination of both. One dog received only NSAID after surgery. Overall median survival time (MST) was 730 days (range 20–2345 days). The MST of dogs with a tumor mitotic count < 10/10 HPF was 1393 days (range 20–2345 days). The dogs with a tumor mitotic count of 10 or greater/10 HPF had a MST of 433 days (range 169–831 days). There was no significant difference of MST among different treatment modalities. Local recurrence was noted in 13 cases (40.6%) and the median time to recurrence was 115.5 days (range 50–1610 days). The median time to local recurrence in dogs with mitotic count of < 10/10 HPF was 339 days (range 68–1610 days) and in dogs with mitotic count of 10 or greater/10 HPF was 119 days (range 50–378).
    [Show full text]
  • Ultra-Rare Cystic Disease
    SERIES ULTRA-RARE LUNG DISEASE Ultra-rare cystic disease Davide Elia1, Olga Torre1, Roberto Cassandro1, Antonella Caminati1 and Sergio Harari 1,2,3 Number 2 in the Series “Ultra-rare lung disease” Edited by Sergio Harari and Marc Humbert Affiliations: 1U.O. di Pneumologia e Terapia Semi-Intensiva Respiratoria - Servizio di Fisiopatologia Respiratoria ed Emodinamica Polmonare, Ospedale San Giuseppe - MultiMedica IRCCS, Milan, Italy. 2Dept of Medical Sciences San Giuseppe Hospital MultiMedica IRCCS, Milan, Italy. 3Dept of Clinical Sciences and Community Health, University of Milan, Milan, Italy. Correspondence: Roberto Cassandro. U.O. di Pneumologia e Terapia Semi-Intensiva Respiratoria - Servizio di Fisiopatologia Respiratoria ed Emodinamica Polmonare, Ospedale San Giuseppe - MultiMedica IRCCS, Via San Vittore 12, 20123 Milan, Italy. E-mail: [email protected] @ERSpublications Diffuse cystic lung diseases show a characteristic CT scan pattern that often allows for diagnosis, even in asymptomatic patients, allowing prompt correct therapy and management without the needing of a biopsy https://bit.ly/2wIUKet Cite this article as: Elia D, Torre O, Cassandro R, et al. Ultra-rare cystic disease. Eur Respir Rev 2020; 29: 190163 [https://doi.org/10.1183/16000617.0163-2019]. ABSTRACT Diffuse cystic lung diseases include a group of heterogeneous disorders characterised by the presence of cysts within the lung parenchyma, sometimes showing a characteristic computed tomography scan pattern that allows diagnosis. The pathogenetic mechanisms underlying cyst formation in the lung are still not clear and a number of hypotheses have been postulated according to the different aetiologies: ball-valve effect, ischaemic dilatation of small airways and alveoli related to infiltration and obstruction of small vessels and capillaries that supply the terminal bronchioles and connective tissue degradation by matrix metalloproteases.
    [Show full text]
  • Sarcomas in the United States: Recent Trends and a Call for Improved Staging
    www.oncotarget.com Oncotarget, 2019, Vol. 10, (No. 25), pp: 2462-2474 Research Paper Sarcomas in the United States: Recent trends and a call for improved staging Michele M. Gage1, Neeraja Nagarajan1, Jessica M. Ruck1, Joseph K. Canner1, Salma Khan2, Katherine Giuliano1, Faiz Gani1, Christopher Wolfgang1, Fabian M. Johnston1, and Nita Ahuja1,3 1Department of Surgery, Johns Hopkins University, Baltimore, Maryland, USA 2Rehman Medical Institute, Hayatabad, Pakistan 3Department of Surgery, Yale University, New Haven, Connecticut, USA Correspondence to: Nita Ahuja, email: [email protected] Keywords: sarcoma; mesenchymal tumors; connective tissue tumors; SEER; trends of sarcoma Received: November 06, 2018 Accepted: February 19, 2019 Published: March 29, 2019 Copyright: Gage et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Background and objectives: Sarcomas represent a heterogeneous group of tumors, and there is lack of data describing contemporary changes in patterns of care. We evaluated the epidemiology of sarcomas over 12 recent years Methods: The Surveillance, Epidemiology and End Results (SEER) database was queried for sarcoma cases from 2002-2014. Patient, tumor and treatment factors, and trends over time were studied overall and by subtype. Univariable and multivariable logistic regression models and 5-year survival and cause-specific mortality (CSM) were summarized. Results: There were 78,527 cases of sarcomas with an overall incidence of 7.1 cases per 100,000 people, increasing from 6.8 in 2002 to 7.7 in 2014.
    [Show full text]
  • Second Revised Proposed Regulation of the State
    SECOND REVISED PROPOSED REGULATION OF THE STATE BOARD OF HEALTH LCB File No. R057-16 February 5, 2018 EXPLANATION – Matter in italics is new; matter in brackets [omitted material] is material to be omitted. AUTHORITY: §§1, 2, 4-9 and 11-15, NRS 457.065 and 457.240; §3, NRS 457.065 and 457.250; §10, NRS 457.065; §16, NRS 439.150, 457.065, 457.250 and 457.260. A REGULATION relating to cancer; revising provisions relating to certain publications adopted by reference by the State Board of Health; revising provisions governing the system for reporting information on cancer and other neoplasms established and maintained by the Chief Medical Officer; establishing the amount and the procedure for the imposition of certain administrative penalties by the Division of Public and Behavioral Health of the Department of Health and Human Services; and providing other matters properly relating thereto. Legislative Counsel’s Digest: Existing law defines the term “cancer” to mean “all malignant neoplasms, regardless of the tissue of origin, including malignant lymphoma and leukemia” and, before the 78th Legislative Session, required the reporting of incidences of cancer. (NRS 457.020, 457.230) Pursuant to Assembly Bill No. 42 of the 78th Legislative Session, the State Board of Health is: (1) authorized to require the reporting of incidences of neoplasms other than cancer, in addition to incidences of cancer, to the system for reporting such information established and maintained by the Chief Medical Officer; and (2) required to establish an administrative penalty to impose against any person who violates certain provisions which govern the abstracting of records of a health care facility relating to the neoplasms the Board requires to be reported.
    [Show full text]
  • Myxosarcomata at the State Institute Study Of
    MYXOSARCOMATA WITHA REPORTON 51 CASESSTUDIED AT THE STATEINSTITUTE FOR THE STUDYOF MALIGNANTDISEASE, BUFFALO, NEW YORK A. A. THIBAUDEAU, M.B., AND L. C. KRESS, M.D., F.A.C.S. A perusal of modern texts on pathological anatomy gives us but little information on the subject of the myxosarcoma. A few sentences, or at most a short paragraph, usually suffice for description of this type of neoplasm, and the statements made are often misleading or more than usually vague. Yet during the past century a voluminous literature has been published on, and a vast amount of research devoted to, the myxomatous tumors. Early to attract the attention of pioneers in pathological anatomy, these neoplasms have, through succeeding generations, presented for solution problems which still remain un- solved. The fact that myxomatous or pseudomyxomatous tissue at times appears in many different types of tumor further complicates the study. Maximow makes the definite statement that mucous connec- tive tissue is not present in adult mammals, and continues: “It is found during the development of the embryo in many places of its body, as under the skin, and is a form of the common, loose, irregular con- nective tissue.” Early investigators made intensive studies of this type of tissue in the gelatinous matrix of the umbilical cord, Wharton’s jelly. Frey and others thought that they could demonstrate that the cord is composed of a cellular reservoir with anastomosing tubes on which could condense, in surrounding them, a system of channels, resulting from the condensation of the mucous substance. Thus each cell or branch would occupy the axis of a young connective tissue fiber which would completely enclose it.
    [Show full text]
  • Rare Malignant Pediatric Tumors Registered in the German Childhood Cancer Registry 2001–2010
    Pediatr Blood Cancer 2014;61:1202–1209 Rare Malignant Pediatric Tumors Registered in the German Childhood Cancer Registry 2001–2010 1 2 3 4 Ines B. Brecht, MD, * Claudia Bremensdorfer, Dominik T. Schneider, MD, PhD, Michael C. Fru¨hwald, MD, PhD, 1 5 6 7 Sonja Offenmu¨ller, Rolf Mertens, MD, PhD, Peter Vorwerk, MD, PhD, Ewa Koscielniak, MD, PhD, 7 8 9 10 Stefan S. Bielack, MD, PhD, Martin Benesch, MD, PhD, Barbara Hero, MD, Norbert Graf, MD, PhD, 11 2 Dietrich Von Schweinitz, MD, PhD, and Peter Kaatsch, MD, PhD Background. The German Childhood Cancer Registry (GCCR) 1,189 rare extracranial solid tumors (18.2% of all malignant annually registers approximately 2,000 children diagnosed with a extracranial solid tumors) were registered, among these 232 patients malignant disease (completeness of registration >95%). While most (19.5% of rare tumor cases), were not included in preexisting GPOH pediatric cancer patients are diagnosed and treated according to studies/registries. Within 10 years, the number of registered non- standardized cooperative protocols of the German Society for GPOH-trial patients with a rare tumor increased. Conclusions. Pediatric Oncology and Hematology (GPOH), patients with rare Though most of the GCCR-registered patients with rare malignant tumors are at risk of not being integrated in the network including tumors are treated within GPOH trials, there is a considerable trials and reference centers. Procedure. A retrospective analysis of all number of patients that have been diagnosed and treated outside the rare extracranial solid tumors reported to the GCCR 2001–2010 (age structures of the GPOH.
    [Show full text]
  • The Vet's Guide To
    THE VET’S GUIDE TO ONCOLOGY VOLUME TWO www.sashvets.com VOLUME TWO | CONTENTS 1. Lymphoma 4 2. Mast Cell Tumour 10 3. Soft Tissue Sarcoma 15 4. Osteosarcoma 20 5. Haemangiosarcoma 25 6. Oral Tumours 30 7. Anal Sac Adenocarcinoma 36 8. Client Care 41 CHAPTER ONE LYMPHOMA 3 1. LYMPHOMA DISEASE OVERVIEW In cats lymphoma typically manifests as one of the following: Lymphoma is a cancer that arises from an uncontrolled proliferation of lymphoid cells. As it § Gastrointestinal lymphoma (Gl): this is the is a cancer of a type of white blood cell, lymphoma most common form of feline lymphoma can arise within the lymph nodes or it can arise § Multicentric lymphoma in any site throughout the body. It is the most § Mediastinal lymphoma common cancer in cats and it is observed with § Central nervous system lymphoma relative frequency in dogs. § Ocular lymphoma In some cases, lymphoma may remain localised § Renal lymphoma within the lymphatic system or within its organ of § Nasal lymphoma origin. In most cases, lymphoma is multicentric, resulting in more widespread disease. While location is commonly used to describe lymphoma, there are other classification schemes Usually, the inciting cause of lymphoma is that are also used for both descriptive and unknown. In cats there is a significant correlation prognostic purposes. These characteristics include between the development of lymphoma and tumour staging and tumour grading. infection with FeLV and FIV. Both feline leukaemia virus and feline immunodeficiency virus are Tumour Grade known to contribute to the development of feline lymphoma, although this effect is more pronounced Tumour grade is often used to describe the with feline leukaemia virus.
    [Show full text]