Onderzoekschool Oncologie Amsterdam Oncology Graduate School Amsterdam

Annual Report 2017

Address

Oncology Graduate School Amsterdam OOA VU medisch centrum Kamer CCA 2.52 De Boelelaan 1118 1081 HZ Amsterdam phone : 020 - 444 2406 e-mail : [email protected] website : www.ooa-graduateschool.org

Contents

Preface 7

1 Board and organization 11 2 General report 15 3 Educational activities 23 4 PhD research program 31

Annex 1 Faculty and staff 53 Annex 2 International visitors 71 Annex 3 PhD theses completed 75 Annex 4 Scientific publications 87

Oncology Graduate School Amsterdam OOA

preface

Preface

The Oncology Graduate School Amsterdam (OOA) world-experts, conferences, workshops and meet- has been founded to structure and organize the the-expert sessions. A major effort is put into the education of the oncology oriented graduate organization of the annual graduate student students in the Amsterdam area and to ensure retreat. Next to the benefit of encountering the proper supervision and mentoring. broadly oriented work of fellow students, this retreat teaches the graduate students skills in Three Amsterdam-based institutes, the medical reporting, presenting and collaborative activities. faculties the VU University Medical Center (VUmc) and University of Amsterdam (Universiteit van Next to the teaching program, the OOA organizes Amsterdam- UvA) and the Netherlands Cancer the Diamond Program, a Dutch Science Foundation Institute (Nederlands Kanker Instituut - NKI) are (NWO) funded talent scouting program. collaborating to strive for excellence in research and education in oncology by their participation in This report presents the activities and scientific OOA. output of OOA in 2017. It includes detailed listings of our educational activities, such as training The OOA research covers a wide program ranging programs, and an overview of the scientific output, from basic molecular biology to clinical bedside including listings of PhD theses completed and research. It includes, for instance, fundamental scientific papers published throughout 2017. studies on cellular signal transduction and the control of gene expression, but also clinical trials of new (combination) approaches and the The Executive Directors, development of new tools to evaluate the quality of life in cancer patients. A large proportion of Prof. dr. A.W. Griffioen (VUMC), chair research is translational in nature and aims for the Dr. M. Spaargaren (AMC) development of new diagnostic and therapeutic Prof. dr. H. te Riele (NKI) strategies.

Graduate students of the OOA can choose for their educational program from a range of educational activities, including specialized training courses, training courses for transferable skills, seminars by

Preface - 7

8 - Preface Oncology Graduate School Amsterdam OOA

board and organization 1

1. Board and organization

OOA has a supervisory board of representatives of Participating institutes the three institutions and is managed by three VU University Amsterdam (VU)/ VU University directors, one from each participating institute. Medical Center (VUmc) The directors are supported by a coordinator and a Administrative center secretary staff. The directory board is handling, on Contact: dr. E.M. Ruhé-Hoogervorst behalf of the supervisory board, the actions of the De Boelelaan 1118 OOA. The directory board is responsible for the 1081 HV Amsterdam PhD education programme and also designs and phone : 020-4442406 implements the OOA future policy. email : [email protected]

University of Amsterdam (UvA)/ Academic Medical Board Center (AMC) Prof.dr. E. Eldering (AMC) Meibergdreef 15 Prof.dr. J.P. Medema (AMC) 1105 AZ Amsterdam Prof.dr. R.H. Medema (NKI-AvL) phone : 020-5668502 Prof.dr. C.J.L.M. Meijer (VUmc) fax : 020-5669165 Prof.dr. T.K. Sixma (NKI-AvL) Prof.dr. T. Wurdinger (VUmc) Netherlands Cancer Institute – Antoni van Leeuwenhoek (NKI-AvL) Executive directors Contact: Ms. P. Lagerweij/ R. Muns – de Jong Prof. dr. A.W. Griffioen, chairman (VUmc) Plesmanlaan 121 prof. dr. H. te Riele (NKI-AvL) 1066 CX Amsterdam Dr. M. Spaargaren (AMC) phone : 020-512 6973 fax : 020-512 1944 Coordination email : [email protected] / [email protected]

Dr. E.M. Ruhé (VUmc)

Secretary staff Ms. T. Eggenhuizen (NKI-AvL) Ms. P. Lagerweij (NKI-AvL) Ms. R. Muns – de Jong (NKI-AvL)

Faculty and staff The OOA has faculty members among which prominent members of the scientific community with an excellent track record in science, as measured by their scientific output in international literature and other indicators of high esteem. In addition, they have excellent teaching skills. These supervisors guarantee a superb environment for education in research within the OOA. Staff members and promising junior investigators help them to maintain the highest standards of scientific expertise and teaching skills within the graduate school. The complete list of founding institutes’ faculty and staff involved in educational activities and research projects conducted by OOA is provided in Annex 1.

Board and organization - 11

12 – Board and organization Oncology Graduate School Amsterdam OOA

General report 2

2. General report

Background numerous EU integrated projects and networks of In 1992 the Oncology Graduate School Amsterdam excellence. Funding is also strongly supported by (Onderzoekschool Oncologie Amsterdam – OOA) the Dutch science foundation (NWO) and the Dutch was founded in an effort to structure the education cancer society (KWF). and supervision of the Amsterdam-based PhD students. The OOA is a joint graduate school of the A total of 1609 papers have been published by medical faculties of VU University Amsterdam (VU researchers from the three institutes. Many of Medisch Centrum – VUmc) and the Amsterdam these are collaborative actions between Medical Center (Amsterdam Medisch Centrum – researchers from AMC, NKI-AvL and VUmc. Annex 4 AMC, University of Amsterdam) and the provides the complete list of scientific publications Netherlands Cancer Institute (Nederlands Kanker in 2017. Instituut – NKI)/ Antoni van Leeuwenhoek (AVL). The central secretariat of the OOA is located at VUmc. Highlights OOA In 2017 a PhD student council has been formed to The mission of the OOA is to provide education in facilitate the input from the students to the oncology research in the widest sense at an organization of OOA. This council is staffed by six excellent level, and ensure proper supervision for PhD students, two from each of the participating graduate students in the Amsterdam region. These OOA institutes. The council meets on regular basis students are scientists-in-training who receive and advises the Executive Board on the need for additional theoretical and practical education on additional courses, invitation of international various subjects related to cancer research. speakers and the organization of the yearly PhD Collaboration is encouraged between clinical, student retreat. In addition, the council organizes translational and fundamental researchers. the yearly PhD student day. At this event optional Collaboration is also encouraged between the short courses, workshops and lectures on a broad research groups of the three institutes as well as range of subjects and skills are offered. In 2017 (inter)nationally. In this way, the PhD students this this event was attended by a large group of have the opportunity to conduct high-level PhD students, demonstrating the need for such an research and attend courses that are organized by activity. an outstanding faculty with high scientific output In 2015 the OOA initiated the Diamond program as in international literature and excellent track an NWO funded talent scouting program for the records. transition from master student to PhD student. The Diamond Program laureates are now successfully The OOA is a large and successful graduate school. developing their research programs, as is Among the Dutch graduate schools, the OOA is one exemplified by the paper of Josephine Kahn and of 24 schools in the field of ‘Life Sciences and colleagues in the journal Blood. Medicine’. It is the only school that specifically Another achievement of OOA is the record number focuses on training in basic, translational and of organized courses, which shows the increasing clinical cancer research, which is giving us a very recognition by PhD students and their supervisors strong strategic position. of the OOA principles.

Research highlights OOA institutes Publications and awards Blood-based liquid biopsies have emerged as OOA has an excellent (inter)national status, as promising biomarker sources for non-invasive demonstrated by the large number of research detection of cancer. Here Myron Best et al. projects granted in open national and international demonstrate that particle-swarm optimization calls, including several of the prestigious new (PSO)-enhanced algorithms enable efficient grants. The faculty is strongly represented in the selection of RNA biomarker panels from platelet ‘vernieuwingsimpuls’, the Veni – Vidi - Vici grants RNA-sequencing libraries. This resulted in accurate for junior researchers and participated widely in TEP-based detection of early- and late-stage non- small-cell lung cancer independent of age of the

General report - 15 individuals, smoking habits, whole-blood storage independently predictive for treatment benefit time, and various inflammatory conditions. PSO with a 100% negative predictive value. enabled selection of gene panels to diagnose Implementation of early FDG-PET evaluation in cancer from TEPs, suggesting that swarm daily clinical practice can prevent unnecessary intelligence may also benefit the optimization of toxicity, costs of ineffective treatment and allows diagnostics readout of other liquid biopsy timely treatment adjustment for patients with biosources (Cancer Cell. 32(2):238-252). mCRC undergoing anti-EGFR treatment. Although tamoxifen inhibits the progression of Hodgkin lymphoma (HL) survivors treated with breast cancer, it increases the risk of endometrial radiotherapy and/or chemotherapy are known to cancer in postmenopausal women. Marjolein Droog have increased risks of heart failure (HF), but a et al. showed that he ERα-binding sites in radiation dose-response relationship has not tamoxifen-associated endometrial tumors differed previously been derived. Frederika van Nimwegen from those in the tumors from nonusers and had et al showed that anthracycline-containing distinct underlying DNA sequences and divergent chemotherapy increased HF rate by a factor of enhancer activity. They also compared ERα sites in 2.83, and there was no significant interaction with tamoxifen-associated endometrial cancers with MLVD (Pinteraction = .09). Twenty-five-year publicly available ERα ChIP-seq data in breast cumulative risks of HF following MLVDs of 0-15 Gy, tumors and found a striking resemblance in the 16-20 Gy, and ≥21 Gy were 4.4%, 6.2%, and 13.3%, ERα patterns of the two tissue types. This study respectively, in patients treated without highlights the divergence between endometrial anthracycline-containing chemotherapy, and tumors that arise in different hormonal conditions 11.2%, 15.9%, and 32.9%, respectively, in patients and shows that ERα enhancer use in human cancer treated with anthracyclines. These results enable differs in the presence of nonphysiological estimation of HF risk for patients before endocrine stimuli (PNAS, 114(8):E1316-E1325). treatment, during radiotherapy planning, and Tim van Groningen et al. showed that most during follow-up. (Blood, 129(16):2257-2265) neuroblastomas include two types of tumor cells Marianne Rutten et al. showed that diagnostic with divergent gene expression profiles. laparoscopy reduced the number of futile Undifferentiated mesenchymal cells and laparotomies in patients with suspected advanced- committed adrenergic cells can interconvert and stage ovarian cancer. In women with a plan for resemble cells from different lineage primary cytoreductive surgery (PCS), these data differentiation stages. ChIP-seq analysis of isogenic suggest that performance of diagnostic laparoscopy pairs of mesenchymal and adrenergic cells first is reasonable and that if cytoreduction to < 1 identified a distinct super-enhancer landscape and cm of residualdisease seems feasible, to proceed super-enhancer-associated TF network for each with PCS (J Clin Oncol. 35(6):613-621). cell type. Mesenchymal cells were more The results of a study of Jop Teepen et al strongly chemoresistant in vitro and were enriched in post- suggest that doxoubicin exposure in childhood therapy and relapse tumors. (Nat Genet. cancer survivors increases the risk of subsequent 49(8):1261-1266). solid cancers and breast cancer, whereas The spatial organization of chromosomes cyclophosphamide exposure increases the risk of influences many nuclear processes including gene subsequent sarcomas. These results may inform expression. The cohesion complex shapes the 3D future childhood cancer treatment protocols and genome by looping together CTCF sites along subsequent malignant neoplasms surveillance chromosomes. Judith Haarhuis et al. showed that guidelines for childhood cancer survivors (J Clin chromatin loop size can be increased and that the Oncol. 35(20):2288-2298). duration with which cohesion embraces DNA determines the degree to which loops are enlarged. They concluded that the balanced Educational activities activity of SCC2/SCC4 and WAPL enables cohesion The core activity of OOA is training PhD students in to correctly structure chromosomes (Cell, conducting cancer research. For this purpose, OOA 169(4):693-707). has developed a high-quality curriculum. In 2017, Despite RAS selection, one third of patients with OOA organized various graduate training courses in metastatic RAS wild-type colorectal cancer (mCRC) a variety of subjects including transferable skills, do not benefit from anti-EGFR inhibitors. masterclasses, meet-the-expert sessions, Therefore, an additional or more accurate conferences and symposiums. All courses were predictive biomarker is needed to identify patients evaluated by means of standardized evaluation with primary resistant mCRC. E van Helden et al procedures. In this way, OOA carefully monitors showed that early evaluation of metabolic the quality of its courses. Based on the outcome of response after 1 dose of cetuximab is highly and

16 – General report these evaluations, the training programs are being Experimental Clinical Research and covers improved continuously. diagnosis of cancer and prevention and therapy of Next to these activities, the OOA organizes the cancer. Chapter 4 provides a listing of all annual graduate student retreat. This retreat is set individual PhD projects conducted within these up as a conference where all students present their main themes. More detailed descriptions of these work and where they are actively involved by research programs and their output are provided in chairing the scientific sessions and catalysing the the annual reports of the founding institutes. discussions. Theme 1: Experimental biology A detailed description of all training courses The transformation of a normal cell into a offered in 2017 is provided in chapter 3 of this malignant tumor cell requires multiple (epi)genetic Annual Report. alterations affecting genes that control cellular pathways. Studying the genes and proteins involved in these pathways results in better Finances understanding of tumor development, progression Funding of the OOA and therapy resistance. Candidate markers are The annual costs of the teaching programme tested for their ability to predict/detect cancer at (specialized courses, an annual retreat and meet- an early stage. Disease profiling is being improved the-expert sessions with international experts) and using innovative research tools. Tools applied in administrative costs are financed by the three research projects include high-throughput methods participating institutes themselves. The annual for (epi)genetic, transcriptomic and proteomic budget is currently €70,000. analyses. Examples are large tumor cohort screens with CGH, expression arrays or massive parallel In addition, the three participating institutes sequencing, gain-of-function genetic screens with provide administrative support: retroviral cDNA expression libraries, and loss-of- AMC: 0.15 FTE administration function genetic screens with RNA interference and NKI-AVL: 0.60 FTE administration CRISPR/Cas9 libraries. Quantitative mass VUmc: 1.05 FTE coordination and administration spectrometry is being used to search for proteins to distinguish the diseased and disease-free states. Expenses in 2017 were € 14.994,45 for the course Mechanistic studies using e.g. structural biology program, € 63.892,58 for the annual retreat and € complement the functional studies. Advanced 2.011,90 secretary costs. mouse models or sophisticated xenotransplant models have been developed for the genetic Funding of PhD research projects dissection of cancer and testing of therapeutic The PhD research projects are financed by the interventions. At the cellular level, processes like institutes themselves (‘eerste geldstroom’), public cell-cell communication, adhesion, migration, funds (‘tweede geldstroom’) or private funds/ survival, proliferation and differentiation are all industry (‘derde/ vierde geldstroom’). In 2017, 22% being studied. Furthermore, the mechanisms of of the PhD projects was funded by the therapy resistance and metastasis are being participating institutes themselves (primary investigated. funding; ‘eerste geldstroom'); 18% was financed by Viral oncogenesis projects focus on the role of public funds (secondary funding; 'tweede human papilloma viruses and Epstein-Barr virus in geldstroom'), 39% by research contracts from the development of human cancer, by using both in external organisations including cancer charity and vitro models and clinically well-defined patient industrial funds (tertiary funding; ‘derde tumor samples. Viral and host markers are being geldstroom’) and 22% was financed by other funds tested for their capability to assess the risk (quaternary funding; 'vierde geldstroom'). associated with the development of cancer.

Theme 2: Experimental clinical research Research program Improvements of clinical care in oncology are The major strength of the OOA comes from based on improved detection, development of combining basic, translational and clinical oncology innovative therapies and personalized treatment research from three large Amsterdam-based strategies. The emerging and rapidly growing fields academic centres. The research programmes that of molecular imaging and genomics are providing our PhD students are working on can be divided in new opportunities to study the biology of a two main themes. The theme Experimental Biology malignancy in individual patients and thus allowing covers oncogenesis and tumor cell biology as the for the development of highly valuable indicators main lines of research. The second main theme is for diagnosis and prediction of disease outcome.

General report - 17 The development of the 70-gene breast cancer - Oncogenomics Facility: MPS GS-FLEX sequencer predictor at the NKI-AvL has led to the first FDA- (AMC) approved diagnostic screen for breast cancer. - Lentiviral library for RNA-silencing for human Modern state-of-the-art techniques like MRI, and mouse (AMC) SPECT, PET and PET/CT are enabling tumor - Liquid biopsy center (VUmc) imaging with high precision and unique molecular - Mass spectrometry facility (AMC, VUmc) and biological information at the tissue level. - Metabolomics Facility (AMC) (Molecular) reporter probes are being developed - Microarray facilities with high resolution and evaluated. Highly developed mouse models are oligonucleotide array and CGH arrays for mouse being used to follow drug sensitivity in several and human studies (AMC, VUmc) types of cancer and for developing clinical - Microscopy facility, including extensive strategies for imaging. Another important focus of confocal, electron microscopy, high resolution research is targeted cancer therapy. Personalized microscopy, FACs (AMC, NKI-AvL, VUmc) therapy should ensure optimal treatment benefits. - (Molecular) Imaging facilities (MRIdian, Projects include (pre)clinical evaluations of the use cyclotrons, GMP facilities, animal and clinical of neoadjuvant treatment or the application of PET/CT-cameras and MRI-machines) enabling new molecular therapies and anti-angiogenic imaging of anatomical details with high agents against novel targets in the tumor and its precision (AMC, NKI-AvL, VUmc) environment. The pharmacological optimization of - Oncoproteomics laboratory for protein and conventional cytotoxic drugs is an important line of glycan profiling using mass spectrometry (AMC, research, as is the passage of drugs through the NKI-AvL, VUmc) blood-brain barrier. Development of - Protein expression and biophysical immunotherapies based on adoptive transfer and characterization facility (NKI-AvL) vaccination strategies are at the forefront of - Radionuclide Center (NKI-AvL, VUMC) research. These, as well as novel targeted (anti- - Radiotherapy facilities (NKI-AvL, VUmc) angiogenic) therapies and gene therapy strategies - Robotics and screening facility, including high are being developed and tested in clinical trials. content imaging (NKI-AvL) Another important clinical research theme is - Sequencing facility (NKI-AvL) quality of life for childhood and adult patients with - Technology Transfer Office (AMC, NKI-AvL, cancer. VUmc) - Tissue microarray facility (AMC, VUmc) - Transgenic Core (NKI-AvL) Facilities The main goal of all research activities of the three OOA institutes is to better understand the PhD projects and students development of cancer and to improve the Overall, more than 800 PhD projects were actively perspectives of cancer patients. For this purpose, elaborated throughout 2017. The names of the PhD many state-of-the-art technologies are present and students, supervisor and at the three OOA new initiatives have been developed. Information institutes are listed in chapter 4. about innovative technologies is communicated at many occasions, including courses and the OOA A total number of 90 PhD students completed and retreat. These technologies are open to PhD defended their PhD thesis in 2017. Annex 3 students within OOA. As a result, the OOA PhD provides the complete list of PhD students who students often have early access to novel obtained their degree with details of their theses techniques and can apply these in research. and graduation.

The state-of-the-art facilities include: - Animal Pathology and Histology (NKI-AVL) International visitors - Animal facilities (AMC, NKI-AvL, VUmc) Training of PhD students can be stimulated and - Bio-informatics laboratory (AMC, NKI-AvL) enhanced by having scientific interactions between - Biobanking (AMC, NKI-AvL, VUmc) students and foreign experts operating in the field - Bioimaging (NKI-AvL) of the students’ research projects. OOA is part of a - Central Clinical Trial Support (office) (AMC, large international network of cancer researchers VUmc) and, therefore, international guests from other - Deep sequencing facility (AMC, NKI-AvL) research institutes visit OOA’s institutes frequently - Extensive animal facilities (AMC, NKI-AvL) to interact with OOA students and staff. In - (Flow) cytometry facilities - Coulter, BD, addition, conferences and symposiums are Acumen (AMC, NKI-AvL, VUmc)

18 – General report frequently organized in the Amsterdam area, allowing students to interact internationally. Throughout 2017, we welcomed 48 international experts in various settings (Annex 2).

General report - 19

20 – General report Oncology Graduate School Amsterdam OOA

Educational activities 3

3. Educational activities

For on-the-job training, the PhD student gets support Courses are advertised on the OOA website and in his/her work from the project leader, post-docs and announced by e-mail to the PhD students. Students technicians, and this research is embedded in make a selection from these courses compliance with established research groups within the three their interest and background. All courses are taught participating institutes. The PhD students attend and in English. participate in scientific staff meetings, work discussions, journal clubs, and – where applicable – Courses are typically given by senior staff members, patient meetings. Moreover, attending seminars, i.e. full professors, as well as associate- (UHD) and symposia and congresses is encouraged. Students assistant professors (UD). At VUmc and AMC several regularly meet with experts in the field through meet- formal training programmes for lecturers are in place. the-expert sessions after seminars given by One of them is a “teach the teacher” programme. internationally acclaimed scientists. The three OOA Most core teachers hold a University Teaching institutes are actively involved in organizing and co- Qualification (Basiskwalificatie Onderwijs - BKO). organizing national and international scientific All OOA courses are evaluated by the participating conferences, symposia and workshops, including the students through an evaluation form (see annual symposia at the OOA institutes. Prominent reports on our website for the evaluation scores). international scientists visit the OOA research Comments are requested on the organization and institutes within the context of existing or new content of the course and the performance of research collaborations in which PhD students are also individual speakers. involved. Many PhD students spend time at international research institutes of high reputation. In 2017, 11 courses and 1 Meet-the-Expert session were organized. In addition, the Annual Graduate The OOA has a longstanding tradition of providing an Student Retreat was organized again in 2017. Courses education programme made up of high quality courses included lectures given by (inter)national experts, on a wide range of topics in oncology. This programme demonstrations and practical training. is supplemented by courses on transferable skills (e.g. poster presenting, time-management, career An informal agreement has been made with the planning), work discussions, journal clubs, Medical Genetics Centre South-West Netherlands conferences and meetings that are organized by the (Medisch Genetisch Centrum Zuid-West Nederland – three participating institutes. MGC; Erasmus Medical Center and the Leiden The educational programme is flexible and focuses on University Medical Center), the Graduate Schools of cutting edge scientific topics and the core research the Radboud University Medical Center and the activities of the OOA, covering diverse topics in Utrecht Graduate School of Life Siences (Clinical & oncology ranging from functional genomics to animal Translational Oncology – CTO; Utrecht Medical models, from protein structure to invasion and Center). Major aim of this collaboration is to join metastasis. A part of the training programme is forces by making the educational programme devoted to new technologies and will provide the accessible to all PhD students in oncology of the students with the skills and expertise to apply these participating graduate schools. OOA PhD students methods in their own research. Meet-the-expert were allowed to participate in the CTO courses sessions are organized to offer the PhD students the ‘Modern Cancer Pathology’, ‘Head and Neck Oncology’ opportunity to discuss their work with experts from and ‘Clinical Trial Development’. outside the OOA institutes. A highlight of the educational programme is the three-day annual PhD student retreat, which focuses entirely on the research conducted by the students themselves. The educational program, designed by the OOA directors, is based on evaluations of former courses, new developments in cancer research and educational needs expressed by PhD students.

Educational activities - 23 Biobusiness Organization: Prof. dr. A.W. Griffioen, Dr. J. van A total number of 50 OOA PhD students participated in Beijnum, Dr. E. Huijbers (VUmc) the course. The overall rating was 3.9 (scale 1-5). Date: January 23 – February 3 ECTS: 3.0 Radiation Oncology Scientific discoveries can be developed for Organization: Dr. P. Sminia (VUmc), Dr. J.J. Sonke commercial application. Success of entry into the (NKI-AvL), Dr. L. Stalpers (AMC) market is dependent on factors, such as intellectual Date: March 13 - 17 property, indication selection, (pre)clinical testing ECTS: 1.5 and financial aspects. This 2-week course was organized to get attendants familiar with the concepts This course provided an overview of (1) radiobiological behind the valorization of research ideas and and physical principles of radiation oncology (2) technology. Seminars were given by top-notch technical innovation in precision radiotherapy (3) the speakers, ranging from researchers with starting spin- route of the radiotherapy patient - via diagnosis, off companies, experts on patenting, regulatory issues imaging and treatment planning – to therapy. and venture capital, to CEOs of large and successful Topics that were addressed: effects of irradiation on companies. the DNA and cellular level, radiation response of The goal of the course was to provide insight in the tumours and normal tissues, physics of modern factors that dictate success in present-day conformal radiotherapy, imaging, treatment planning development of therapeutics and diagnostics. and treatment of cancer patients with radiation alone

or combined with chemotherapy or targeted agents. A total number of 8 OOA PhD students participated in The course also encompassed three practical the course. The overall rating was 4.0 (scale 1-5). trainings: (1) the radiobiology laboratory (2)

computer-based target volume delineation (3) patient

treatment simulation on a linear accelerator. In How to write high impact papers and what addition, three PhD students were invited to give an to do when your manuscript is rejected overview of their research project. Organization: Y.M. Duiker, prof. dr. J.C. Coyne, Dr. E.M. Ruhé (VUmc) A total number of 29 OOA PhD students participated in Date: February 8 and 20 the course. The overall rating was 4.0 (scale 1-5). ECTS: 0.4

The process of getting scientific papers published is undergoing dramatic changes. Many papers are Mouse Morphology, Genetics & Function rejected without being sent for peer review and yet Organization: Jurgen Seppen (AMC), Eric Reits other papers appear on PubMed within weeks of (AMC), Mona Edvartsen (AMC) submission. There is an increasing need to capture an Date: April 3-13 editor’s enthusiasm based on the title, cover letter, ECTS: 2.6 and abstract alone if a manuscript is even to be sent out for formal peer review. Animal experiments, especially using mice and rats, This workshop introduced strategies for writing are an important part of many PhD projects. A better journal articles. Topics included: The changing world understanding of rodent anatomy, histology, of scientific publishing, creative use of web-based pathology, genetics, wellbeing, and a proper resources, crafting a catchy storyline for cover letters perspective of the difference of rodent models versus and the abstract, the Elevator Talk as a way of human physiology can improve the quality of these organizing abstracts and cover letters and the basic experiments substantially. structure of the manuscript, voiding the perils of Course participants were introduced into various inadvertent plagiarizing and salami slicing, integrating aspects of research with rodents. The aim was to daily writing into your life style, writing and rewriting increase awareness of the physiology and genetics of the manuscript, getting your manuscript past the experimental animals thereby enabling better editor and sent out for peer review, postsubmission planning and execution of animal research. responsibilities, writing cover letters and responses to Participants followed lectures in the morning and reviewers’ comments, strategizing when your learn hands-on skills in the afternoon. manuscript is rejected, why you should write press The subjects covered included: Anatomy (dissection) releases, using self-citation, twitter, and publicity to of adult male and female mice, microscopic and increase early citations. pathological anatomy of rodent tissues and organs,

Educational activities - 24 dealing with pathologically changed animals, developmental and neuro-anatomy; comparison of The ability to modify genes at the level of the germ rodent and human anatomy, imaging the mouse (MRI line by transgenesis and gene targeting has been and PET/SPECT), gene targeting, transgenic crucial for our understanding of gene function and has strategies, and generation of mouse models, mouse yielded many highly valuable models for human breeding and querying the Jax phenotype database, diseases. This course dealt with the basic principles rodent behavior and experimental outcomes. underlying the generation of transgenic, knock-out (KO) and knock-in (KI, i.e., gene-modified rather than A total number of 13 OOA PhD students participated in gene-inactivated) mice. the course. The overall rating was 8.1 (scale 1-10). Most recently, the spectacular advances in CRISPR/Cas9-assisted gene modification have found wide application in mouse genetics. CRISPR/Cas9- Basic Microscopy Course “In the Footsteps technology strongly facilitates gene targeting in ESCs, of Antoni van Leeuwenhoek” but can also directly be used in zygotes, evading the Organization: Dr. J.A.M. Beliën (VUmc), Dr. L. ESC route. Both applications were presented, as well Brocks (NKI-AvL), Dr. Juan J. Garcia- as the application of CRISPR/Cas9 technology in non- Vallejo (VUmc), Dr. R. Hoebe (AMC), germ-line gene modification. H. Janssen (NKI-AvL), Prof. dr. R. The course consisted of lectures covering technology Mebius (VUmc), Dr. L. Oomen (NKI- and applications of genetic engineering in basic and AvL), T. O’Toole (VUmc), Dr. E.A.J. medical research. Practical demonstrations showed Reits (AMC), Dr. J. Stap (AMC), H. crucial steps in the generation of transgenic, KO and van Veen (AMC), Dr. N van de Wel KI mice, and principles of in vivo imaging. (AMC) The first three days of the course preparee Date: May 15-19 participants for the 2-day international workshop on ECTS: 1.5 Innovative Mouse Models (IMM 2017) immediately following the course. Keynote lectures from leading This course teaches the application of a range of laboratories and presentations from selected abstracts imaging possibilities. They are presented in lectures, will discuss the latest developments on advanced discussions and hands-on demonstrations. The genome modification protocols and its applications in individual research projects of the attending fundamental biology and biomedical research. Course participants were discussed in relation to the participants participated in ‘meet-the-expert’ demonstrated techniques, allowing exchange of ideas sessions. with fellow participants and microscopy experts and operators. The course is a guide to implement cellular A total number of 15 students participated in the imaging in the research project of the participants. A course. The overall rating was 8.1 (scale 1-10). part of the participants could bring their sample for analysis after consulting with the organization first. Annual Graduate Student Retreat Topics covered include: basic principles of microscopy Organization: Prof. dr. H. te Riele (NKI-AvL), P. and confocal laser scanning microscopy, specimen Lagerweij (NKI-AvL) preparation and staining methods, quantitative Date: October 11-13 analysis of microscopic images (e.g. Image J), electron ECTS: 2.0 microscopy techniques, Imagestream, ultramicroscoop Location: Renesse and 2-photon, live cell imaging (e.g. inverted automated fluorescence and Total Internal Reflection Each year OOA organizes a three-day retreat for all Fluorescence) graduate students participating in the OOA. This

retreat focuses entirely on research conducted by the A total number of 16 students participated in the graduate students themselves. Students not only course. The overall rating was 4.5 (scale 1-5). present their work as a poster in the first year of their

participation and as an oral presentation in

subsequent years, they are also in charge of chairing Genetic engineering in model organisms: sessions and discussions. Awards are given for the technology and application in basic and three best presentations and best posters. The retreat medical research trains important skills in presentation and interaction Organization: J. Verbeek, E. Robanus Maandag, H. but it also provides an overview of research conducted te Riele (MGC/LUMC – NKI-AvL) within OOA at an early stage of the student’s career, Date: June 12-16 contributing significantly to the interaction between ECTS: 1.8 the students of the different participating institutes

Educational activities - 25 and also between the students of different divisions Matlab is one of the most widely used and easiest to within the same institute: clinical and fundamental. learn programming languages and programming The retreat is considered stimulating both environments in academia today. scientifically as well as socially. This course trained the participants to code in Matlab: This year, all OOA retreat participants were invited to to design, implement and run their own programs, to join the workshop ‘Do’s & don’ts of (poster) analyze and visualize their data with code that was presenting your PhD research to a broad audience’ found online or that was build from scratch. The which took place at September 15th . participants started at absolute beginner level, and eased their way into more advanced topics. After an A total of 188 PhD students participated in this introduction to the basics of data types, commands retreat. The overall evaluation rate was 4.2 (scale 1- and scripts, the course was focussed on writing 5). functions, creating plots and automatically processing hundreds of files with a personal data analysis pipeline. Basic Microscopy Course “In the Footsteps of Antoni van Leeuwenhoek” A total of 12 PhD students participated in this course. The overall evaluation rate was 4.1 (scale 1-5). Organization: Dr. J.A.M. Beliën (VUmc), Dr. L. Brocks (NKI-AvL), Dr. Juan J. Garcia- Vallejo (VUmc), Dr. R. Hoebe (AMC), Basic Medical Statistics H. Janssen (NKI-AvL), Prof. dr. R. Organization: M. Hauptman (NKI-AvL), K. Jozwiak Mebius (VUmc), Dr. L. Oomen (NKI- (NKI-AvL) AvL), T. O’Toole (VUmc), Dr. E.A.J. Date: November 13-17 Reits (AMC), Dr. J. Stap (AMC), H. ECTS: 1.5 van Veen (AMC), Dr. N van de Wel (AMC) This 5-day course explained statistical techniques for Date: October 23-27 the evaluation of biomedical data. It provided an ECTS: 1.5 introduction into design aspects, methods of summarizing and presenting data, estimation, This course teaches the application of a range of confidence intervals and hypothesis testing, including imaging possibilities. They are presented in lectures, multivariable regression methods for the assessment discussions and hands-on demonstrations. The of association. Although the course focusses somewhat individual research projects of the attending on methods and examples from clinical research, it participants were discussed in relation to the should be useful for experimental researchers as well. demonstrated techniques, allowing exchange of ideas The emphasis will be on practical application and with fellow participants and microscopy experts and interpretation rather than theory. operators. The course is a guide to implement cellular imaging in the research project of the participants. A A total of 47 PhD students participated in the course. part of the participants could bring their sample for The overall evaluation rate was 4.3 (scale 1-5). analysis after consulting with the organization first. Topics covered include: basic principles of microscopy and confocal laser scanning microscopy, specimen Advanced O2Flow Cytometry preparation and staining methods, quantitative Organization: J. Garcia-Vallejo (VUmc) analysis of microscopic images (e.g. Image J), electron Date: November 14-16 microscopy techniques, Imagestream, ultramicroscoop ECTS: 1.0 and 2-photon, live cell imaging (e.g. inverted automated fluorescence and Total Internal Reflection Cytometry has become a fundamental method in the Fluorescence) life sciences that provides support and enables application in multiple disciplines including A total number of 16 students participated in the fundamental (Cell Biology), translational course. The overall rating was 4.5 (scale 1-5). (Immunology) and clinical research (Hematology and Oncology). This was a comprehensive course that covered the fundamentals of flow cytometry analysis Programming in Matlab for beginners and sorting, mass cytometry, and imaging flow Organization: L. Hoyng (VUmc) cytometry in a lecture format supplemented by Date: October 30, November 2, 6, 9, 13 practical lab sessions. The course was designed to and 20 teach students how a cytometer works, the basics of ECTS: 1.0 fluorescence, how to properly set up a cytometer for

Educational activities - 26 standardized performance, how cell sorting works, and other specialized applications, including data analysis. We placed an distinct emphasis on providing a wide overview of the different modalities of cytometry currently available and all specialized applications that can be of used for the PhD students in the fields of Immunology, Hematology, and Oncology. The course concluded with a feedback session where students presented their own PhD projects and the most appropriate cytometry approaches were discussed.

A total of 18 PhD students participated in the course. The overall evaluation rate was 4.4 (scale 1-5).

OOA Meet-the-Expert session with prof. dr. Vishva Dixit Organization: Prof. dr. H. te Riele, prof. dr. R. Bernards (NKI-AvL), dr. ir. E. Frische Date: November 19 ECTS: 0.3

The meet-the-expert session with Vishva Dixit was part of the CGC annual meeting ‘New Horizons in Cancer Research’ that was held at the Koninklijk Instituut voor de Tropen, Amsterdam on November 16 & 17, 2017. . Participants of the meet-the-expert session were invited to discuss their own work, and the work of Prof. Dixit (vice president and staff scientist, Physiological Chemistry, Genentec) in an informal (lunch) session. For information about the work of prof. Dixit: please see www.gene.com/scientists/our- scientists/vishva-dixit

A total of 9 PhD students participated in the course. The overall evaluation rate was 4.4 (scale 1-5).

Educational activities - 27

Educational activities - 28 Oncology Graduate School Amsterdam OOA

PhD research program 4

4. PhD research program

This chapter describes the PhD projects conducted. * PhD students who obtained their PhD degree in 2017 # PhD students who stopped their PhD research in 2017

Last name Initials Department Institute start date

Aalbergsberg E Pharmacy and Pharmacology NKI 01-nov-12 Aarts B Radiology NKI 16-nov-17 Abdul K Medical Oncology VUmc 15-dec-15 Aben N Molecular Carcinogenesis NKI 01-feb-14 Abis GSA Surgery VUmc 01-nov-12 Achetib N Biomedical Engineering and Physics AMC 03-jan-16 Adam RSM Center for Experimental and Molecular Medicine/CEMM AMC 01-aug-16 Adamopoulos AN Biochemistry NKI 01-sep-14 Admiraal M Radiation Oncology VUmc 15-sep-09 Agnass P Surgery AMC 15-dec-15 Ahrends T Immunology NKI 01-aug-13 Alaeikhanehshir S Molecular Pathology NKI 01-jul-17 Alendar A Molecular Genetics NKI 06-mrt-02 Aleyd* E Molecular Celbiology and Immunology VUmc 01-jan-13 Al-Itejawi H Urology VUmc 01-sep-13 Almasian M Biomed. Eng. & Phys AMC 01-nov-12 Almekinders M Pathology NKI 01-jan-16 Alphen van C Hematology VUmc 09-jan-12 Amelsfoort van R Radiotherapy NKI 01-okt-16 Andel van H Pathology AMC 01-mrt-11 Andel van L Pharmacology NKI 01-apr-14 Anderegg MCJ Surgery AMC 01-mrt-12 Ankersmit M Surgery VUmc 01-mrt-11 Annunziato S Molecular Pathology NKI 01-okt-16 Anselma M Social Medicine VUmc 01-jan-16 Apriamashvili G Molecular biology NKI 01-okt-16 Arik B Ophthalmonology AMC 01-aug-13 Arkani M Pulmonology VUmc 01-nov-17 Arnamo H Pharmacology NKI 01-mrt-17 Asif PJ Center for Experimental and Molecular Medicine/CEMM AMC 01-feb-17 Aslam M Tumor Biology And Immunology NKI 01-jan-14 Atema V Psychosocial Research and Epidemiology NKI 01-feb-15 Attekum* van MHA Experimental Hematology and Immunology AMC 01-sep-11 Baal van J Medical Oncology NKI 01-mei-14 Baal van JOAM Obstetrics and Gynaecology AMC 01-mei-14 Baar van ACG Gastroenterology AMC 04-jun-14 Babala N Immunology NKI 01-aug-13

PhD research program - 31 Last name Initials Department Institute start date Babion I Pathology VUmc 01-nov-14 Bach S Surgery VUmc 02-jan-17 Badrising S Cmedical Oncology NKI 01-feb-14 Bahjat M Pathology AMC 01-dec-12 Bakker JL Clinical Genetics VUmc 01-sep-10 Bakker J Cell Biology II NKI 01-sep-10 Bani Yassien A Radiotherapy NKI 04-jan-16 Barazas M Molecular Oncology NKI 25-feb-13 Barbaria AH Molecular Celbiology and Immunology VUmc 01-nov-15 Bar-Ephraim* J Molecular Celbiology and Immunology VUmc 01-jul-12 Bartels L AIMM Therapeutics AMC 15-sep-15 Bassi A Epidemiology and Biostatistics VUmc 15-jan-15 Bastiaenen VP Surgery AMC 15-mrt-17 Bate Eya* LT Oncogenomics AMC 01-jan-10 Beagan J Pathology VUmc 09-mei-16 Beck A Psychosocial Research and Epidemiology NKI 01-sep-15 Beek van de I Clinical Genetics VUmc 01-jan-15 Beekhof R Laboratory Medical Oncology VUmc 01-sep-14 Beekman C Radiotherapy NKI 01-okt-16 Beijer J Pediatric Oncology AMC 01-jul-17 Belghazi K Gastroenterology AMC 03-nov-14 Ben Larbi I Gastroenterology VUmc 05-dec-14 Benedict B Tumor biology & Immunology NKI 01-okt-14 Bennis M Radiation Oncology AMC 01-nov-15 Berg van den J Cell Biology I NKI 01-jan-14 Berk van den I Radiology AMC 01-apr-16 Berndsen B Medical Oncology VUmc 01-jan-14 Bertels LS Huisartsgeneeskunde AMC 01-sep-16 Besancon OG Pediatrics AMC 01-apr-08 Best MG Neurosurgery VUmc 01-aug-14 Beukers F F Pediatric Oncology AMC 01-jan-13 Beusekom van B Biochemistry NKI 01-dec-14 Biesma HD Pathology VUmc 01-okt-16 Bindsbergen van KLA Psychosocial department AMC 01-okt-17 Bismeijer T Molecular Carcinogenesis NKI 01-apr-13 Blanas A Molecular Celbiology and Immunology VUmc 01-mrt-16 Bleijenberg AGC Gastroenterology AMC 20-jun-16 Blijlevens M Laboratory Medical Oncology VUmc 01-okt-14 Bloedjes TA Pathology AMC 01-jun-14 Blok RD Center for Experimental and Molecular Medicine/CEMM AMC 17-mei-16 Blomberg O Molecular Carcinogenesis NKI 01-mei-17 Blomen* V Biochemistry NKI 15-dec-10 Boekel N Psychosocial Research and Epidemiology NKI 27-okt-08 Boer de J Radiotherapy NKI 01-jan-06 Boer de P Radiation Oncology AMC 01-feb-12

32 – PhD research program Last name Initials Department Institute start date Boer de DV Otolaryngology/Head and Neck Surgery VUmc 01-sep-12 Boerdonk* van R Pathology VUmc 01-nov-09 Boersma V Molecular Oncology NKI 01-okt-12 Bogunovic N Surgery VUmc 01-jun-15 Bolhuis K Medical Oncology AMC 01-mei-17 Bolt* EE Social Medicine VUmc 01-jun-11 Bongaarts A Neuropathology AMC 01-jan-16 Boode L Molecular Pathology NKI 01-sep-17 Booij KAC Surgery AMC 01-jan-09 Boons CCLM Pharmacy VUmc 01-jul-09 Boorn van den H Medical Oncology AMC 01-jan-17 Borstlap* WAA Sugery AMC 01-mei-14 Bos P DOD NKI 01-okt-16 Bosch van den T Center for Experimental and Molecular Medicine/CEMM AMC 01-nov-17 Boshuizen J Molecular Oncology NKI 20-jul-15 Boshuizen* R Molecular Oncology & Immunology NKI 01-aug-09 Bosma S Radiotherapy NKI 01-mei-13 Bosman LC Epidemiology and Biostatistics VUmc 02-feb-15 Bosschieter J Urology VUmc 01-feb-16 Both J Genome Analysis AMC 01-nov-07 Bousema JE Pulmonology AMC 01-apr-17 Bouti P Blood Cell Research Sanquin 01-dec-17 Brachtlova T Laboratory Medical Oncology VUmc 01-sep-16 Brahm CG Medical Oncology VUmc 01-jul-15 Brambillasca CS Molecular Pathology NKI 01-jul-14 Braster* R Molecular Cellbiology and immunology VUmc 01-aug-11 Bresser K Molecular Oncology & Immunology NKI 01-aug-14 Brinkman DJ Tytgat Institute for Liver and Intestinal Disease AMC 01-jan-16 Brinkman EK Gene regulation NKI 01-sep-12 Brocco F Surgery AMC 01-okt-16 Broek* van der S Molecular Pathology NKI 01-jan-09 Broekaart D Neuropathology AMC 01-jan-16 Bronsveld* H Molecular Pathology NKI 01-sep-12 Bronzwaer MES Clinical Hematology AMC 17-nov-14 Brueckner S Cell Biology II NKI 01-nov-17 Bruekner L Biochemistry NKI 01-nov-13 Bruggen van JAC Experimental Immunologyn- EXIM AMC 12-okt-15 Bruin M Pharmacology NKI 01-nov-17 Bruin* de RCG Medical Oncology VUmc 01-jan-11 Brummelen* van E Pharmacology NKI 01-jan-14 Brunen* D Molecular Carcinogenesis NKI 01-okt-12 Bruns ERJ Surgery AMC 01-mrt-15 Brunschot van S Gastroenterology AMC 01-okt-09 Buijs M Urology AMC 04-mei-15 Buikhuisen JY Center for Experimental and Molecular Medicine/CEMM AMC 01-dec-13

PhD research program - 33 Last name Initials Department Institute start date

Buoninfante A Tumor Biology & Immunology NKI 01-jun-13 Burggraaf MJ Medical Microbiology and Infection Control VUmc 01-nov-14 Burggraaff CM Laboratory Hematology VUmc 01-jan-15 Bussel van M Pharmacology NKI 01-jan-15 Butter R Pathology AMC 17-jul-17 Byng D Psychosocial Research and Epidemiology NKI 01-sep-17 Caramanna I Medical Psychology VUmc 01-okt-17 Cervera-Carrascon VE Medical Oncology VUmc 29-feb-16 Chalabi M Medical Oncology & Immunology NKI 01-feb-16 Chandrupatla DMSH Reumatology VUmc 15-jan-13 Chang J Tytgat Institute for Liver and Intestinal Disease AMC 01-mei-12 Chen Z Experimental Immunologyn- EXIM AMC 09-jan-17 Chen T Gene regulation NKI 10-apr-12 Chomet-van Leeuwen M Radiology & Nuclear Medicine VUmc 01-okt-16 Chuwonpad A Sanquin - Hematopoiesis AMC 01-jan-16 Ciampricotti M Tumor Biology & Immunology NKI 01-feb-09 Cioni B Molecular Genetics NKI 01-okt-13 Clercq de N Internal Medicine AMC 01-dec-15 Collette ERP Urology VUmc 18-jul-16 Commandeur MC Oncogenomics AMC 01-mei-12 Cordo V Medical Oncology VUmc 02-okt-17 Cornelissen LAM Molecular Celbiology and Immunology VUmc 01-jun-14 Cornelissen L Molecular Pathology NKI 01-okt-12 Correia AC Center for Experimental and Molecular Medicine/CEMM AMC 15-jan-14 Creemers A Internal Medicine Oncology AMC 01-jan-16 Cremers EMP Laboratory Hematology VUmc 01-jan-16 Crombag LMM Respiratory Medicine AMC 17-sep-12 Crommentuijn* MHW Vumc 01-jan-13

Cucchi D Laboratory Hematology VUmc 01-jun-16 Cysouw MCF Radiology & Nuclear Medicine VUmc 01-jul-16 Dackus G Molecular Pathology NKI 01-apr-12 Dallinga MG Ophthalmonology AMC 15-mrt-12 Deijen* CL Surgery Vumc 01-feb-14 Deijver J Neurology VUmc 01-jan-17 Deinum J Radiology & Nuclear Medicine VUmc 15-feb-16 Deken M Medical Oncology&Immunology NKI 01-nov-12 Delaney AR Radiotherapy VUmc 01-sep-16 Delgado R Experimental Immunologyn- EXIM AMC 01-okt-16 Derks Y Anatomy and Neuroscience VUmc 01-jan-14 Derks J Anatomy and Neuroscience VUmc 01-mei-14 Derks* M Obstetrics and Gynaecology AMC 03-jan-11 Detering R Surgery AMC 01-mei-17 Dharadhar S Biochemistry NKI 01-okt-13 Dias M Molecular Pathology NKI 01-sep-16 Dickhoff* C Surgery VUmc 01-jun-14

34 – PhD research program Last name Initials Department Institute start date

Diessen van J Radiotherapy NKI 01-mrt-13 Dijkvan S Mondziekten AMC 01-jan-13 Dijk van M Pediatric Oncology VUmc 16-mei-14 Dijk van N NKI 15-jan-17

Dijkgraaf F Molecular Oncology&Immunology NKI 01-okt-12 Dijkhoff R NKI 13-nov-17

Dijksterhuis WP Medical Oncology AMC 01-jul-17 Dijkstra K Medical Oncology&Immunology NKI 01-jan-14 Dinaux AM Surgery VUmc 15-jan-16 Dinther van D Molecular Celbiology and Immunology VUmc 01-jun-14 Dodewaard JM Medical Oncology VUmc 01-jan-12 Doesschateten F Psychosocial department AMC 01-feb-16 Doeveren van T Medical Oncology NKI 01-sep-15 Dohmen A Medical Oncology NKI 01-jan-11 d'Olivo P Pediatric Oncology VUmc 01-jan-14 Donner N Pathology AMC 01-okt-15 Doornebal C Tumor Biology&Immunology NKI 01-jul-09 Douma LN Social Medicine VUmc 01-mrt-14 Douma JAJ Medical Oncology VUmc 01-jun-16 Drees E Pathology VUmc 05-sep-16 Drent E Laboratory Hematology VUmc 01-sep-14 Droog* M Molecular Pathology NKI 01-jan-11 Duetz C Hematology VUmc 08-mei-17 Duineveld LAM Huisartsgeneeskunde AMC 15-aug-12 Duinkerken S Molecular Celbiology and Immunology VUmc 01-okt-14 Duits LC Gastroenterology AMC 01-okt-11 Dusoswa SA Molecular Celbiology and Immunology VUmc 01-dec-14 Dykvan E Molecular Carcinogenesis NKI 01-okt-09 Ebbing EA Internal Medicine Oncology AMC 01-sep-12 Edenvan H Medical Oncology NKI 01-sep-14 Eggermond# van A Psychosocial Research and Epidemiology NKI 01-jul-09 Egmond*v an MP Social Medicine VUmc 01-nov-11 Eijgelaar R Radiotherapy NKI 15-mei-15 Eijkelenburg van NKA Pediatric Oncology AMC 01-jul-07 Eisden TTHD Laboratory Medical Oncology VUmc 01-dec-14 El Hassouni B Laboratory Medical Oncology VUmc 01-apr-17 Elbers J Medical Oncology NKI 01-okt-15 Eleveld T Oncogenomics AMC 01-jul-11 Elhorst Benites T Medical Oncology VUmc 01-okt-17 El-Khouly FE Pediatric Oncology VUmc 01-jan-16 Elshof* L Molecular Pathology NKI 01-sep-12 Elshot YS Dermatology AMC 01-jul-14 Engbersen M Radiology NKI 21-aug-17 Engelsman-Theelen W Medical Oncology NKI 01-apr-13 Erkarghali Z Radiomics and immunotherapy NKI 01-okt-17

PhD research program - 35 Last name Initials Department Institute start date

Erkelens MN Molecular Celbiology and Immunology VUmc 01-apr-15 Erozenci LA Medical Oncology VUmc 01-jul-17 Erve van 't I DOD NKI 01-okt-17 Escala Garcia M Molecular Pathology NKI 15-jul-16 Eskes* MM Medical Oncology NKI 01-dec-13 Fanchi L Molecular Oncology&Immunology NKI 01-nov-12 Farag-Kal S Medical Oncology NKI 01-jul-14 Feenstra H Psychosocial Research and Epidemiology NKI 25-jul-11 Feringa F Cell Biology I NKI 01-okt-11 Fernandes C Radiotherapy NKI 01-mei-15 Feund JE Urology AMC 01-mrt-16 Flach K Oncogenomics NKI 17-jun-12 Fliers JM Gastroenterology AMC 01-jan-17 Franke V HOD NKI 01-mei-17 Franke* NE Pediatric Oncology VUmc 01-apr-06 Franken LC Experimental Surgery AMC 15-nov-17 Fransen van de Putte E Medical Oncology NKI 01-feb-14 Franssen LE Hematology VUmc 01-sep-14 Franzen N Psychosocial Research and Epidemiology NKI 01-sep-17 Frerichs K Hematology VUmc 01-aug-16 Frijlink E Immunology NKI 03-okt-16 Frijstein M Medical Oncology NKI 15-aug-15 Fruiten van der N Surgery VUmc 01-jan-15 Gan C Molecular Oncology NKI 01-sep-15 Gangaev A Molecular Oncology&Immunology NKI 01-okt-16 Garcia Nieto A Gene regulation NKI 01-aug-17 Geenen J Pharmacology NKI 01-aug-15 Geest van der LGM Surgery AMC 01-sep-15 Genc CG Chirurgie Staf AMC 01-okt-15 Gerritse S Medical Oncology VUmc 01-jan-17 Gerwen van M MOD NKI 01-jun-17 Geukes Foppen M Medical Oncology NKI 01-jun-13 Giardiello D Molecular Pathology NKI 15-nov-16 Gillissen MA Celbiol & Histol AMC 16-mrt-12 Gilsvan N Laboratory Hematology VUmc 01-mei-16 Gisler S Molecular Genetics NKI 01-okt-11 Glas R Pathology NKI 01-sep-17 Glykofridis I Clinical Genetics VUmc 01-sep-15 Go S Tytgat Institute for Liver and Intestinal Research AMC 01-jan-17 Goedegebuure R Medical Oncology VUmc 01-mei-17 Gogola E Molecular Oncology NKI 30-jul-12 Gomez Solsona B Radiotherapy NKI 01-sep-17 Gonzalez A Cell Biology I NKI 01-jan-13 Gooijerde M Medical Oncology NKI 01-jun-13 Gool van MMJ Molecular Celbiology and Immunology VUmc 30-jul-16

36 – PhD research program Last name Initials Department Institute start date

Gootjes EC Medical Oncology VUmc 01-jan-13 Gouw Z Radiotherapy NKI 01-sep-14 Grabowska J Molecular Celbiology and Immunology VUmc 01-jun-17 Greidanus MA Coronel Institute AMC 01-sep-15 Greuter* MJE Pathology VUmc 01-sep-12 Grewal SK Molecular Celbiology and Immunology VUmc 01-sep-11 Groen E Pathology NKI 01-jan-16 Groenland S Medical Oncology NKI 01-dec-16 Groningen van TJ Medical Oncology AMC 15-jan-08 Groof de AJ Gastroenterology AMC 01-nov-15 Groot de D Molecular Oncology & Immunology NKI 09-okt-17 Groot H Psychosocial Research and Epidemiology NKI 15-feb-12 Gunawan S Pediatric Oncology VUmc 01-jan-13 Gurney-Champion* OJ Radiation Oncology AMC 01-nov-12 Haan de R Radiotherapy NKI 01-nov-11 Haar van de J Medical Oncology&Immunology NKI 01-sep-16 Hagens E Surgery AMC 01-apr-16 Hakim S Otolaryngology/Head and Neck Surgery VUmc 01-mei-11 Hakkert A Oncogenomics AMC 15-okt-14 Halsema van EE Gastroenterology AMC 01-apr-14 Hamming L Internal Medicine VUmc 07-feb-17 Hamming-Vrieze O Radiotherapy NKI 01-nov-11 Han R Oncogenomcis NKI 01-okt-13 Handgraaf S Tumor Biology&Immunology NKI 15-mrt-17 Hanekamp DW Laboratory Hematology VUmc 01-jan-15 Harmsen T Tumor Biology&Immunology NKI 01-jul-11 Harten van M Medical Oncology NKI 01-jan-13 Harten van AM Otolaryngology/Head and Neck Surgery VUmc 01-aug-13 Hartog ID Medical Oncology AMC 01-sep-14 Haselager M Experimental Immunologyn- EXIM AMC 09-jan-17 Haumann R VUmc 01-aug-17

Hazelaar C Radiation Oncology VUmc 18-nov-15 Heerden van LE Graduate School AMC 01-okt-13 Heeren AM Obstetrics and Gynaecology VUmc 03-feb-14 Heijden van der MCS Center for Experimental and Molecular Medicine/CEMM AMC 01-jul-12 Heijden van der M Biological Stress Response NKI 01-nov-15 Heijmans N N UvA 01-jan-14

Heinhuis K Pharmacology NKI 01-jun-16 Helden van EJ Medical Oncology VUmc 28-okt-13 Helderman FCPA Radiotherapy AMC 01-sep-17 Hellingman T Surgery VUmc 01-jan-17 Hellingman D DOD NKI 01-nov-17 Hendricks L Pharmacology NKI 01-sep-14 Hertog D Oral and Maxillofacial Surgery and Pathology VUmc 01-sep-09 Hessen E Radiotherapy NKI 01-jan-17

PhD research program - 37 Last name Initials Department Institute start date

Heukelom J Radiotherapy NKI 01-jul-12 Hiemstra AC Pathology VUmc 01-jan-11 Hilhorst H Hematology VUmc 01-jan-15 Hilst van J Surgery AMC 01-mei-15 Hira VVV Medical Biology AMC 01-aug-16 Hodzic J Laboratory Medical Oncology VUmc 01-feb-09 Hoefen Wijsard van M Ophthalmonology VUmc 01-mei-17 Hoefnagel SJM Gastroenterology AMC 01-jun-16 Hoekstra M Molecular Oncology&Immunology NKI 01-feb-14 Hoes L Molecular Oncology&Immunology NKI 01-mei-17 Hofland T Experimental Hematology and Immunology AMC 15-sep-14 Hognasbacka AA Radiology & Nuclear Medicine VUmc 15-nov-16 Hol MLF Oral and Maxillofacial Surgery and Pathology AMC 02-feb-15 Holthof LC Laboratory Hematology VUmc 19-dec-14 Holtmaat K Clinical Psychology VUmc 01-dec-14 Hooi D Obstretics and Gynaecology VUmc 01-jan-13 Hoorn ten S CEMM/Lexor AMC 01-mrt-17 Hoppe van S Molecular Oncology NKI 01-mrt-14 Hoppes# R Cell Biology II NKI 01-jan-07 Horrevorst SK Molecular Celbiology and Immunology VUmc 01-feb-14 Horst van der H Laboratory Hematology VUmc 01-dec-15 Houlleberghs* H Tumor Biology&Immunology NKI 01-dec-10 Hout van den M Pathology VUmc 01-jul-08 Hout van der A Clinical Psychology VUmc 07-jan-15 Houwen BBSL Gastroenterology and Hepatology AMC 01-okt-17 Hoveling RJM Biomedical Engineering and Physics AMC 15-okt-12 Hoyng LL Radiology & Nuclear Medicine VUmc 01-nov-11 Hu Y Experimental Surgery AMC 15-okt-17 Huang X Molecular Oncology&Immunology NKI 30-sep-13 Huijberts S Pharmacology NKI 01-apr-16 Huijgevoort van N Gastroenterology AMC 17-mei-16 Huijskens SC Radiation Oncology AMC 01-okt-14 Huijts CM Medical Oncology VUmc 01-jan-11 Huiskens J Surgery AMC 03-mrt-15 Huizing D Medical Oncology NKI 01-apr-16 Hummel L Psychosocial Research and Epidemiology NKI 03-dec-12 IJff M Center for Experimental and Molecular Medicine/CEMM AMC 01-sep-17 Ijspeert* JEG Gastroenterology AMC 01-apr-13 Ikink G Molecular Oncology&Immunology NKI 01-mei-10 Indraswari BW Pediatric Oncology VUmc 01-jan-15 Iskit S Molecular Oncology NKI 01-sep-09 Israels T Pediatric Oncology VUmc 01-apr-12 Jacobse J Psychosocial Research and Epidemiology NKI 01-okt-13 Jalvehgaran Esfahani MP Biomedical Engineering and Physics AMC 16-mrt-16 Jamaeial AA Oral and Maxillofacial Surgery and Pathology VUmc 21-apr-16

38 – PhD research program Last name Initials Department Institute start date

Jansen F Otolaryngology/Head and Neck Surgery VUmc 15-okt-13 Jansen SM Biomedical Engineering and Physics AMC 01-feb-14 Jansen RW Radiology & Nuclear Medicine VUmc 01-mei-16 Jansen BH Urology, Radiology & Nuclear Medicine VUmc 01-mei-17 Jansen# SR Experimental Immunology AMC 18-jan-16 Janssen J Pathology AMC 01-aug-13 Janssen L Cell Biology I NKI 17-okt-16 Janssen N Radiotherapy NKI 01-nov-13 Jaramillo Mantilla A Medical Oncology VUmc 01-dec-12 Jauw YW Hematology VUmc 01-jan-13 Jin P Radiotherapy AMC 01-okt-13 Jochems F Molecular Carcinogenesis NKI 01-sep-17 Jong de G Hematology AMC 17-nov-14 Jong de A Radiology & Nuclear Medicine VUmc 01-jan-16 Jong* de MC Radiotherapy NKI 01-jan-07 Jong* de MC Radiology & Nuclear Medicine VUmc 01-nov-15 Jonge de NA Internal Medicine VUmc 01-apr-14 Joosten S Oncogenomics NKI 01-dec-15 Kaaij van der R Medical Oncology NKI 01-jan-14 Kabukye JK Clinical information science AMC 01-nov-16 Kadouch* DJ Dermatology AMC 01-okt-09 Kahn J Molecular Carcinogenesis NKI 01-sep-15 Kallenberg* FGJ Gastroenterology AMC 01-dec-13 Kalter J Epidemiology and Biostatistics VUmc 01-jan-12 Kampshoff* CS Social Medicine VUmc 01-apr-10 Kanev G Neurosurgery VUmc 09-jan-15 Kappert K Medical Oncology NKI 01-okt-16 Karsten RT Medical Oncology NKI 01-dec-16 Kas S Molecular Pathology NKI 01-sep-11 Katsarou A Hematology VUmc 01-jan-17 Keikes L Internal Medicine AMC 01-apr-15 Kenski J Molecular Oncology&Immunology NKI 01-mei-14 Kerkhoff N Laboratory Hematology VUmc 01-nov-12 Kersten* K Tumor Biology&Immunology NKI 01-mei-11 Kesteren van F Cardiology AMC 01-okt-13 Khelil# M Obstetrics and Gynaecology AMC 11-dec-17 Khurshed M Celbiologie en Histologie AMC 01-feb-17 Kim R Biochemistry NKI 01-jul-12 Kirov A Center for Experimental and Molecular Medicine/CEMM AMC 16-jul-16 Klaassen R Oncogenetics AMC 01-aug-13 Klaver CEL Surgery AMC 01-sep-14 Klaver EJ Gastroenterology AMC 20-jul-15 Klawer E Radiotherapy NKI 01-feb-14 Kleef van JJ Medical Psychology AMC 01-okt-15 Kleibeuker EA Laboratory Medical Oncology VUmc 01-sep-13

PhD research program - 39 Last name Initials Department Institute start date

Klein K Pediatric Oncology VUmc 01-feb-14 Klerk de CM Gastroenterology AMC 01-dec-15 Klerk de L Medical Oncology VUmc 01-sep-16 Klompmaker S Surgery AMC 01-feb-15 Kneppers J Oncogenomics NKI 01-jun-17 Knops RR Pediatric Oncology AMC 01-nov-09 Koedam TWA Surgery VUmc 01-feb-16 Koemans W HOD NKI 01-jul-17 Kok L Molecular Oncology&Immunology NKI 10-jun-13 Kok D Biochemistry NKI 01-sep-13 Komór MA Medical Oncology VUmc 01-jan-14 Komor G Pathology NKI 01-sep-14 Konert T Pharmacy and Pharmacology NKI 01-dec-14 Kooi* EI Clinical Genetics VUmc 01-nov-16 Kooij L Psychosocial Research and Epidemiology NKI 01-feb-15 Kooijmans ECM Pediatric Oncology VUmc 01-dec-16 Koole S MOD NKI 01-apr-17 Koopman T Radiology & Nuclear Medicine VUmc 15-aug-15 Kooreman E NKI 01-sep-17

Kooten van JAMC Pediatric Oncology VUmc 01-sep-17 Koppel ten M Social Medicine VUmc 01-jan-15 Koppens* M Molecular Genetics NKI 03-feb-09 Korrel M Surgery AMC 01-dec-17 Korsten L Otolaryngology/Head and Neck Surgery VUmc 01-mrt-14 Korthout T Gene regulation NKI 01-sep-13 Kos K Tumor Biology&Immunology NKI 10-okt-16 Koster BD Medical Oncology VUmc 01-jan-12 Kraal* KCJM Pediatric Oncology AMC 01-mrt-11 Kramer GM Radiology & Nuclear Medicine VUmc 01-apr-14 Kramer I Molecular Pathology NKI 01-aug-16 Kranen* van SR Radiotherapy AMC/NKI 25-mrt-14 Krejcik J Hematology VUmc 01-jan-14 Kremer WW Epidemiology and Biostatistics VUmc 18-jun-15 Krijger de I Molecular Oncology NKI 01-nov-12 Kroon MAGM Apotheek AMC 01-sep-17 Kruger DT Medical Oncology VUmc 01-sep-13 Kruizinga* R Internal Medicine Oncology AMC 01-mei-12 Krul I Psychosocial Research and Epidemiology NKI 01-feb-12 Kuijsten L Pharmacology NKI 01-nov-17 Kuiper J Radiation Oncology VUmc 01-okt-15 Kunzli HT Hematology AMC 03-dec-12 Kwakman R Surgery VUmc 01-mrt-15 Kwint M Radiotherapy NKI 01-aug-17 Laan J Radiation Oncology AMC 16-apr-16 Labeur T Medical Oncology AMC 04-jul-16

40 – PhD research program Last name Initials Department Institute start date

Labots M Medical Oncology VUmc 01-sep-14 Lam* SW Medical Oncology VUmc 01-feb-17 Lambrecht M Radiotherapy NKI 31-mrt-14 Lameris R Medical Oncology VUmc 01-sep-13 Lanschot van M Pathology NKI/AMC 01-feb-15 Lansu J Radiotherapy NKI 01-mrt-16 Lantermans HCEREJ Pathology AMC 01-sep-15 Large le TYS Surgery VUmc 01-apr-16 Latenstein AEJ Surgery AMC 01-nov-17 Leeksma A Experimental Immunologyn- EXIM AMC 01-jan-15 Leemans C 1 Gene regulation NKI 01-apr-16 Leerink JM Cardiology AMC 01-okt-17 Leestemaker Y Cell Biology I NKI 01-aug-11 Leeuwen van CM Radiation Oncology AMC 01-dec-12 Leij* van der F Radiotherapy NKI 01-jul-10 Lekkerkerker* SJ Gastroenterology AMC 01-apr-13 Lens* E Radiotherapy AMC 15-aug-12 Leun van der A Medical Oncology&Immunology NKI 22-jun-15 Leyton Puig* D Cell Biology I NKI 01-dec-11 Li RJE Molecular Celbiology and Immunology VUmc 01-dec-14 Li W Molecular Oncology NKI 01-sep-16 Li L OncogenomicsOncogenomics NKI 01-jan-14 Lidth de Jeude van JF Gastroenterlogy AMC 01-nov-11 Liem EIM Urology AMC 02-feb-15 Lier van YF Clinical Hematology AMC 01-dec-15 Lindenberg M Psychosocial Research and Epidemiology NKI 15-sep-15 Linder S oncogenomics NKI 01-jun-17 Lindt van de T Radiotherapy NKI 01-feb-14 Linnekamp JF Center for Experimental and Molecular Medicine/CEMM AMC 16-sep-13 Lint de K Clinical Genetics VUmc 01-aug-16 Lint# de K Molecular Carcinogenesis NKI 01-mei-10 Lodeizen O Urology AMC 02-jan-17 Lodestijn SC Center for Experimental and Molecular Medicine/CEMM AMC 01-aug-15 Logtenberg M Molecular Oncology&Immunology NKI 05-okt-15 Lohuis J Molecular Pathology NKI 01-okt-17 Loke DR Radiotherapy AMC 01-nov-17 Lommerts JE Dermatology AMC 01-okt-14 Lopes R OncogenomicsOncogenomics NKI 01-mei-11 Lopez Gonzalez M Laboratory Medical Oncology VUmc 01-jan-16 Lopez-Venegas MA Molecular Celbiology and Immunology VUmc 03-apr-17 Los-de Vries GT Pathology VUmc 01-dec-16 Louhanepessy R Molecular Genetics NKI 01-mei-16 Lubberding S Otolaryngology/Head and Neck Surgery VUmc 01-jan-16 Lucas M Biomedical Engineering and Physics AMC 01-sep-15 Luimstra J Cell Biology II NKI 15-aug-12

PhD research program - 41 Last name Initials Department Institute start date

Luttmer* R Pathology VUmc 01-jul-11 Lutz C Molecular Pathology NKI 01-jun-17 Machiels M Radiation Oncology AMC 15-okt-13 Mackay T Surgery AMC 01-jun-17 Mackelenbergh van MG Medische Oncology AMC 18-apr-17 Mackovicová Mackovicová Pathology AMC 01-sep-10 Madu M Medical Oncology NKI 01-jun-15 Maliepaard EM 1 Gene regulation NKI 01-jan-16 Mammatas C Medical Oncology VUmc 01-jun-13 Mannaerts CK Urology AMC 01-jun-16 Mansour M Huisartsgeneeskunde AMC 01-sep-16 Mantini G Medical Oncology VUmc 01-mei-17 Manuel Santos J Pathology VUmc 01-jan-16 Maree SC Radiation Oncology AMC 01-feb-16 Mari* L Gastroenterology AMC 15-nov-11 Martens R Radiology & Nuclear Medicine VUmc 01-sep-15 Martens AWJ Experimental Immunologyn- EXIM AMC 15-nov-16 Martinez Ara M Gene regulation NKI 01-okt-17 Martinez Chavez D Molecular Oncology NKI 01-sep-16 Martins M Pharmacology NKI 01-dec-17 Masoumi Kouhestani N Pathology VUmc 15-apr-14 Matos TR Dermatology AMC 01-jun-16 Mayayo Peralta I Molecular Pathology NKI 01-dec-16 McCool-Kramer D Psychosocial Research and Epidemiology NKI 01-jan-15 McNeill NA Ophthalmonology VUmc 01-sep-15 Medendorp NM Medical Psychology AMC 01-mei-16 Meel MH Pediatric Oncology VUmc 01-mrt-14 Meer van der AN Respiratory Medicine AMC 01-jan-16 Meer van der MC Radiotherapy AMC 01-sep-16 Meesters A Dermatology AMC 01-apr-13 Meijer B Tytgat Institute AMC 10-feb-14 Meijer LL Surgery VUmc 08-jun-15 Mencarelli A Radiotherapy NKI 01-jan-08 Mendeville MS Pathology VUmc 19-aug-13 Menning* S Psychosocial Research and Epidemiology NKI 01-okt-10 Mensink M Immunology NKI 01-okt-16 Merino Tejero E Bioinformatics AMC 15-mrt-17 Mes SW Otolaryngology/ Head and Neck Surgery VUmc 01-jan-14 Metselaar DS Pediatric Oncology VUmc 01-apr-16 Meulepas J Psychosocial Research and Epidemiology NKI 01-jan-11 Mezzadra R Molecular Oncology&Immunology NKI 01-sep-10 Milenova I Laboratory Medical Oncology VUmc 01-apr-16 Minderman M Pathology AMC 01-sep-15 Miok V Pathology VUmc 02-jan-12 Mirck B Medical Oncology NKI 01-jan-11

42 – PhD research program Last name Initials Department Institute start date

Moises da Silva A Molecular Pathology NKI 01-dec-17 Molenaar T Gene regulation NKI 01-okt-14 Molenaar* RJ Celbiol & Histol AMC 01-aug-13 Mons E Cell Biology II NKI 01-jul-14 Moosdijk van A UvA 01-jan-14

Morra A Molecular Pathology NKI 01-mrt-16 Moumbeini B OncogenomicsOncogenomics NKI 15-apr-16 Mourits DL Ophthalmonology VUmc 01-okt-12 Mulder J Pharmacology NKI 01-mei-17 Mulero Sanchez A Molecular Carcinogenesis NKI 01-sep-17 Muller M Medical Oncology NKI 01-okt-15 Müller DMJ Neurosurgery VUmc 01-jan-15 Mungroop TH Surgery AMC 01-aug-15 Munster van SN Gastroenterology AMC 01-jan-16 Naaktgeboren W Psychosocial Research and Epidemiology NKI 01-sep-17 Nahidi Azar* L Cell Biology I NKI 01-mrt-12 Narayan RS Radiation oncology VUmc 01-jan-11 Nauta IH Otolaryngology/Head and Neck Surgery VUmc 16-sep-16 Nederlof I Pathology NKI 01-nov-17 Neefjes ECW Medical Oncology VUmc 01-jun-11 Neerincx M Medical Oncology VUmc 01-jan-11 Neerven van SMM Center for Experimental and Molecular Medicine/CEMM AMC 15-jun-15 Neijenhuis KI Clinical Neurophysiology VUmc 01-jan-15 Neree tot Babberich de MPM Gastroenterology AMC 01-mrt-16 Neto J Molecular Carcinogenesis NKI 01-sep-15 Niemeijer AN Pulmonology VUmc 01-aug-14 Nieuwenhuis J Biochemistry NKI 01-okt-12 Nieuwenhuizen van AJ Otolaryngology/Head and Neck Surgery VUmc 01-okt-11 Nijland ML Internal Medicine ALG AMC 01-jan-14 Nissen IA Clinical Neurophysiology VUmc 01-jan-14 Njuguna* F Pediatrics VUmc 01-jan-09 Noij DP Radiology & Nuclear Medicine VUmc 01-sep-16 Noorda van der M Medical Oncology NKI 01-nov-15 Nuland van M Pharmacology NKI 01-okt-15 Oei* ALM Radiation Oncology AMC 01-apr-13 Offringa T Medical Oncology VUmc 01-jan-12 Olbara G Pediatric Oncology VUmc 01-jan-13 Olde Heuvel J DOD NKI 21-aug-17 Omar SZ Experimental Immunologyn- EXIM AMC 19-jun-17 Ooft S Medical Oncology&Immunology NKI 01-jun-15 Oomens MAE Oral and Maxillofacial Surgery and Pathology VUmc 01-jan-17 Oort Q Neurology VUmc 01-jan-15 Oostendorp van S Colorectal surgery VUmc 01-sep-17 Ottega Marin K Radiotherapy NKI 01-okt-16 Ottenhof S Medical Oncology NKI 01-jan-15

PhD research program - 43 Last name Initials Department Institute start date

Palit S Molecular Carcinogenesis NKI 01-jun-15 Passchier E Medical Oncology NKI 01-mei-16 Patel H NKI 01-okt-17

Pees AL Radiology & Nuclear Medicine VUmc 01-jun-16 Peinado Cortes L Biomed. Eng. & Phys. AMC 15-nov-13 Pekosak A Radiology & Nuclear Medicine VUmc 04-nov-13 Persoon S Social Medicine AMC 01-mrt-10 Petersen M Medical Oncology NKI 01-apr-15 Peulen* H Radiotherapy NKI 01-jan-11 Pieters W Tumor Biology&Immunology NKI 01-aug-15 Pilzecker B Tumor Biology&Immunology NKI 15-apr-15 Pinto Barbera E Molecular Genetics NKI 15-apr-16 Pirpinia K Radiotherapy AMC/NKI 01-okt-13 Plat VD Surgery VUmc 01-jan-17 Poel D Medical Oncology VUmc 01-mrt-14 Pogacar Z Molecular Carcinogenesis NKI 01-okt-15 Polman NJ Pathology VUmc 01-dec-13 Ponds FAM Gastroenterology AMC 01-sep-11 Poramba D Gene regulation NKI 01-sep-13 Post AL Biomedical Engineering and Physics AMC 01-jun-14 Postema AW Urology AMC 01-jan-14 Postema FAM Medical Oncology AMC 01-apr-15 Postrach D Molecular Pathology NKI 01-dec-17 Prasetyanti PR Center for Experimental and Molecular Medicine/CEMM AMC 01-jul-10 Priem B Laboratory Medical Oncology AMC/VU 02-jan-17 Protik A Radiotherapy NKI 01-sep-13 Puijk R Radiology & Nuclear Medicine VUmc 01-jan-17 Putten* van der L Otolaryngology/Head and Neck Surgery VUmc 01-feb-05 Qendri V Epidemiology and Biostatistics VUmc 01-apr-15 Ramayanti O Pathology VUmc 15-jul-11 Ramesh P Center for Experimental and Molecular Medicine/CEMM AMC 01-okt-15 Ramovs V Cell Biology I NKI 01-nov-13 Ramshorst* van M Medical Oncology NKI 01-mrt-13 Rappard van DF Pediatric Oncology VUmc 15-sep-13 Rassam F Experimental Surgery AMC 01-nov-16 Rauschenberger A Epidemiology and Biostatistics VUmc 01-nov-14 Ravesteyn van T Tumor Biology&Immunology NKI 01-sep-13 Ren Z Pathology AMC 01-sep-12 Reuling EMBP Pulmonology VUmc 01-jul-15 Rigter* L Medical Oncology NKI 01-mei-13 Rijken JA Otolaryngology/Head and Neck Surgery VUmc 01-okt-11 Rijlaarsdam- Hoekstra L 1 Gene regulation NKI 01-nov-16 Rijssen van LB Surgery AMC 18-jun-14 Rikkert L Laboratory Experimental Clinical Chemistry AMC 01-okt-15 Roberti S Psychosocial Research and Epidemiology NKI 01-dec-17

44 – PhD research program Last name Initials Department Institute start date

Rodrigues Neves C Dermatology VUmc 01-aug-15 Rodriguez Camejo JE Molecular Celbiology and Immunology VUmc 15-dec-15 Roemer* MGM Pathology VUmc 01-jan-12 Roest de R Otolaryngology/Head and Neck Surgery VUmc 01-dec-15 Rog PSJ Pathology VUmc 15-apr-14 Rohaan M MOD NKI 08-mei-17 Rond de L Biomedical Engineering and Physics AMC 01-okt-15 Rood* JAJ Internal Medicine VUmc 01-jan-10 Roodbeen S Surgery AMC 01-dec-17 Rooij de T Surgery AMC 01-apr-14 Rooij* de MFM Pathology AMC 01-jun-14 Roos E Surgery AMC 01-jan-16 Roos VH Gastroenterology and Hepatology AMC 15-mrt-16 Ros W Pharmacology NKI 01-jan-15 Rosmolen WD Gastroenterology AMC 01-jan-09 Rossum van A Molecular Pathology NKI 01-apr-13 Rotman J Obstetrics and Gynaecology VUmc 06-jun-16 Rovithi MN Medical Oncology VUmc 01-jan-15 Rozeman L Medical Oncology&Immunology NKI 01-jan-16 Rozendaal* R Radiotherapy NKI 01-sep-13 Ruarus A Radiology & Nuclear Medicine VUmc 01-nov-16 Ruijgrok C Epidemiology and Biostatistics VUmc 15-aug-15 Ruis RM Biomedical Engineering and Physics AMC 01-nov-17 Ruiten van M Cell Biology I NKI 01-sep-16 Ruiter de J Molecular Pathology NKI 05-nov-12 Sahillioglu A Molecular Oncology & Immunology NKI 15-okt-13 Saldago Polo F Biochemistry NKI 17-jul-17 Salomon# I Molecular Pathology NKI 01-jan-12 Salvagno C Tumor Biology&Immunology NKI 01-feb-13 Samuels* S Obstetrics and Gynaecology VUmc/NKI 01-dec-12 Sande van der M Medical Oncology NKI 01-okt-15 Savci Heijink CD Pathology AMC 01-aug-09 Schaik van T 1 Gene regulation NKI 01-dec-15 Schans van der J Hematology VUmc 26-jun-17 Scheepbouwer C Neurosurgery VUmc 01-mrt-17 Scheinin* AI Pathology VUmc 02-feb-11 Scheltema MJ Urology AMC 11-jan-16 Schep R Gene regulation NKI 01-sep-16 Schepers* SA Pediatrics AMC 01-sep-11 Schetters STT Molecular Celbiology and Immunology VUmc 01-mei-14 Schie van M Radiotherapy NKI 15-sep-15 Schie van J Oncogenetics VUmc 01-okt-17 Schipper K Molecular Pathology NKI 01-jun-14 Schokker S Medical Oncology AMC 21-nov-16 Scholten L Surgery AMC 16-nov-15

PhD research program - 45 Last name Initials Department Institute start date

Scholvinck* DW Gastroenterology AMC 01-mrt-11 Schooneveldt G Radiation Oncology AMC 01-feb-13 Schouten R Medical Oncology NKI 01-dec-15 Schouten* CS Otolaryngology/Head and Neck Surgery VUmc 01-jan-16 Schouten* P Molecular Pathology NKI 01-nov-10 Schrijver L Psychosocial Research and Epidemiology NKI 01-sep-10 Schroder L Radiotherapy NKI 01-jul-16 Schuitema* I Pediatrics VUmc 01-jan-12 Schunselaar L Cell Biology II NKI 01-nov-12 Schurink N DOD NKI 16-okt-17 Schuurhuizen CSEW Medical Oncology VUmc 15-nov-13 Schwarzmuller LJ Center for Experimental and Molecular Medicine/CEMM AMC 15-nov-17 Sciarrillo R Laboratory Hematology VUmc 01-feb-14 Seijen van M Molecular Pathology NKI 01-jul-17 Sewing* ACP Pediatric Oncology VUmc 01-apr-12 Shah R Tumor Biology & Immunology NKI 01-okt-17 Shahul Hameed D Cell Biology II NKI 01-jan-12 Sie* DLS Pathology VUmc 01-mrt-10 Siebring-van Olst E Pulmonology VUmc 01-feb-09 Slagter A Radiotherapy NKI 01-dec-17 Slagter M Molecular Oncology&Immunology NKI 01-feb-15 Slaman AE Surgery AMC 01-jan-14 Slot S Hematology VUmc 01-sep-14 Sluis* van der TM Urology VUmc 01-jan-10 Sluiter NR Surgery VUmc 01-jan-17 Smeenge M Urology AMC 01-nov-10 Smets AMJB Radiation Oncology AMC 15-apr-13 Smit WAA Gastroenterology AMC 01-dec-15 Snoek BC Pathology VUmc 01-nov-13 Soares Vieira B Radiotherapy NKI 01-feb-15 Sobral Leite M Molecular Pathology NKI 01-nov-13 Soer EC Pathology AMC 10-aug-15 Soeratram T Pathology VUmc 01-nov-17 Sol N Neurology VUmc 01-mei-13 Soolingen van L MOD NKI 15-aug-17 Soto Ruiz de la Torre M Cell Biology I NKI 01-nov-14 Spaan C Tytgat Institute for Liver and Intestinal Disease AMC 02-feb-15 Spaan M Psychosocial Research and Epidemiology NKI 01-mei-10 Spanjaard A Tumor Biology & Immunology NKI 01-mrt-17 Spits M Cell Biology II NKI 01-jan-14 Spronsen van M Laboratory Hematology VUmc 01-mei-15 Stadt van de EA Pulmonology VUmc 01-sep-17 Stankovic U Radiotherapy NKI 01-feb-12 Staring J Biochemistry NKI 01-dec-10 Starreveld D Psychosocial Research and Epidemiology NKI 01-aug-16

46 – PhD research program Last name Initials Department Institute start date

Steen* van der N Medical Oncology VUmc 01-mrt-13 Steenbruggen T Medical Oncology NKI 01-okt-15 Steins A Internal Medicine AMC 02-dec-13 Stelloo S Oncogenomics NKI 01-feb-13 Stelten S Epidemiology and Biostatistics VUmc 01-jan-17 Steur LMH Pediatric Oncology VUmc 01-dec-14 Stiekema* A Obstetrics and Gynaecology AMC/NKI 01-jan-14 Stoker* SD Otolaryngology/Head and Neck Surgery VUmc/NKI 01-feb-11 Stolk DA Molecular Celbiology and Immunology VUmc 01-okt-15 Stouten-Kemperman M Psychosocial Research and Epidemiology NKI 01-jul-10 Stoutjesdijk F Pediatric Oncology VUmc 01-jan-17 Straatman J Surgery VUmc 01-okt-13 Straub D Gastroenterology AMC 01-okt-11 Streefkerk N Pediatric Oncology AMC 01-jan-15 Strijker M Surgery AMC 01-mei-16 Struyvenberg MR Gastroenterology AMC 14-aug-17 Sun J Oncogenomics NKI 09-mei-16 Susilawati D Pediatric Oncology VUmc 01-jan-13 Sustic T Molecular Carcinogenesis NKI 01-sep-13 Swaan A Biomedical Engineering and Physics AMC 01-jan-14 Swager* AF Gastro-enterology AMC 15-aug-13 Sweegers M Epidemiology and Biostatistics VUmc 01-sep-15 Szeto Y Radiotherapy NKI 01-sep-12 Taghavirazavizaeh M Medical Oncology NKI 01-sep-16 Tame M Cell Biology II NKI 01-jan-12 te Molder L Cell Biology I NKI 01-sep-14 Teixera* S Medical Oncology NKI 01-sep-12 Tekatli H Radiation Oncology VUmc 01-nov-14 Tekin C Center for Experimental and Molecular Medicine/CEMM AMC 01-nov-15 ter Stege J psychosocial Research and Epidemiology NKI 01-okt-15 Terra L Psychosocial Research and Epidemiology NKI 01-okt-17 Tetar S Radiation Oncology VUmc 01-sep-17 Thijssen B Molecular Carcinogenesis NKI 01-mrt-13 Thuijs NB Pathology VUmc 01-okt-17 Thus Y Pathology AMC 01-feb-17 Tijeten F Oral and Maxillofacial Surgery and Pathology VUmc 01-jan-16 Tilborg* van AAJM Radiology&nuclear medicince VUmc 01-jan-16 Tilburg van G Cell Biology II NKI 01-jun-13 Tio DCKS Dermatology VUmc 20-apr-15 Torre van der J Molecular Oncology NKI 01-feb-06 Torres Xirau I Radiotherapy NKI 01-okt-14 Trebeschi S Medical Oncology NKI 01-mei-16 Treffers L Blood Cell Res AMC 01-jan-14 Troost R Medical Microbiology and Infection Control VUmc 01-dec-16 Uckelmann M Biochemistry NKI 01-nov-11

PhD research program - 47 Last name Initials Department Institute start date

Uijterwaal* MH Pathology VUmc 01-jan-11 Uilkema SB Radiotherapy NKI 01-jun-13 Vaarwerk B Pediatric Oncology AMC 01-apr-15 Valstar MH Oral and Maxillofacial Surgery and Pathology AMC 01-jun-13 Vancura A Neurosurgery VUmc 01-jul-16 Veen van M Biochemistry NKI 01-mei-11 Veenendaal van L Medical Oncology NKI 01-jan-16 Veenstra VL Center for Experimental and Molecular Medicine/CEMM AMC 01-mei-13 Veerter E Internal Medicine Oncology AMC 24-okt-14 Veij Mestdagh de P Psychosocial Research and Epidemiology NKI 01-dec-17 Veld in het S Neurosurgery VUmc 01-mrt-16 Velde van de ME Pediatric Oncology VUmc 01-mei-14 Velden van de D Medical Oncology&Immunology NKI 15-apr-14 Veldhuijzen van Zanten* SEM Paedriatic Oncology VUmc 01-mrt-12 Veldhuisen van E Surgery AMC 01-jul-16 Veluchamy JP Laboratory Medical Oncology VUmc 01-apr-13 Verbruggen L Pediatric Oncology AMC 10-jul-17 Verburg N Neurosurgery VUmc 01-apr-15 Verhagen HJMP Laboratory Hematology VUmc 01-sep-11 Verhagen C Medical Oncology NKI 01-okt-08 Verhoeff JN Molecular Celbiology and Immunology VUmc 01-jun-17 Veringa SJE Pediatric Oncology VUmc 01-mrt-16 Verlaat W Pathology VUmc 01-jun-13 Verma J Endocrine AMC 01-jul-12 Vermeulen R Medical Oncology NKI 01-jan-14 Vermunt M Pharmacology NKI 01-jun-15 Versteeg KS Internal Medicine VUmc 01-sep-12 Versteijne E Radiation Oncology AMC 01-mrt-13 Vessies D NKI 01-okt-17

Vilsteren M Social Medicine VUmc 01-mrt-17 Vink F Pathology VUmc 01-aug-17 Visser L Molecular Pathology NKI 01-mei-14 Visser* NC Medical Psychology AMC 15-jan-13 Vlaming* H Gene regulation NKI 01-nov-10 Vleugels JLA Gastroenterology AMC 02-jun-14 Vliek S Molecular Pathology NKI 01-feb-16 Vlugt* van der M Gastroenterology AMC 01-apr-13 Voabil P Molecular Oncology&Immunology NKI 06-jan-14 Vogel JA Surgery AMC 01-aug-13 Vollenbrock S DOD NKI 01-feb-17 Voncken F Radiotherapy NKI 01-jan-13 Voorwerk L Tumor Biology & Immunology NKI 01-jul-17 Vos JMI Hematology AMC 01-mei-14 Vos J Molecular Oncology & Immunology NKI 01-feb-17 Voskuilen C HOD Urology NKI 01-mrt-17

48 – PhD research program Last name Initials Department Institute start date

Vossen D Biological Stress Response NKI 01-jul-15 Vredevoogd D Molecular Oncology&Immunology NKI 31-aug-15 Vrie van de R Obstetrics and Gynaecology AMC 02-mrt-15 Vriend* LEM Celbiology & Histology AMC 01-nov-12 Vries de S Pharmacy and Pharmacology NKI 01-jan-14 Vries de SDJ Pathology VUmc 01-jan-14 Vries de R Respiratory Medicine AMC 01-okt-14 Vroomen L Radiology & Nuclear Medicine VUmc 01-mrt-15 Waaij de DJ Medical Microbiology and Infection Control VUmc 15-mrt-16 Waart* van H Psychosocial Research and Epidemiology NKI 01-aug-09 Wang Z Radiotherapie AMC 01-sep-15 Wang W Cell Biology I NKI 01-mei-16 Wang L Molecular Carcinogenesis NKI 01-nov-12 Wang J Molecular Oncology NKI 01-nov-15 Wang Y Molecular Oncology NKI 01-nov-15 Wanrooij van RLJ Gastroenterology VUmc 09-dec-14 Weeber* F Medical Oncology&Immunology NKI 01-mrt-14 Weerdt de I Experimental Immunologyn- EXIM AMC 01-nov-13 Weert van S Otolaryngology/Head and Neck Surgery VUmc 01-jan-10 Wegdam W Obstetrics and Gynaecology AMC 01-apr-04 Weger* de V Pharmacy and Pharmacology NKI 01-mrt-13 Weide van der R Gene regulation NKI 01-sep-15 Weijer* R Surgery AMC 15-mei-15 Wel van der MJ Pathology AMC 02-sep-13 Wellenstein M Tumor Biology&Immunology NKI 15-okt-14 Wentink MQ Medical Oncology VUmc 01-sep-12 Werf van der A Nutrition and dietics VUmc 01-apr-14 Werf van der I Pediatric Oncology and Hematology VUmc 01-sep-16 Werkhoven ED Biometrics AMC 01-okt-15 Werter IM Medical Oncology VUmc 01-jan-16 Westendorp BF Tytgat Institute for Liver and Intestinal Disease AMC 01-nov-13 Westerduin E Surgery AMC 01-jan-15 Westgeest HM Medical Oncology VUmc 01-jan-13 Westra WM Gastroenterology AMC 01-apr-08 Wevers M Psychosocial Research and Epidemiology NKI 18-feb-08 Wiel van de H Psychosocial Research and Epidemiology NKI 15-sep-16 Wieldraaijer T Huisartsgeneeskunde AMC 01-okt-13 Wielen# van der N Internal Medicine VUmc 01-jan-15 Wijdeven* R Cell Biology II NKI 01-sep-09 Wijk van der AE Celbiol & Histol AMC 01-dec-12 Wijmans L Respiratory Medicine AMC 01-jan-15 Wijngaart van der H Medical Oncology VUmc 01-jul-17 Wildt* van der B Radiology&Nuclear Medicine VUmc 01-jan-11 Wilk LS Biomedical Engineering and Physics AMC 01-mei-15 Willemsen M Dermatology AMC 29-aug-16

PhD research program - 49 Last name Initials Department Institute start date

Willemsen L Medical Biochemistry AMC 01-jun-17 Willik van der K Psychosocial Research and Epidemiology NKI 19-sep-16 Wind* A Psychosocial Research and Epidemiology NKI 01-mei-13 Windmeijer CAA Radiation Oncology AMC 15-nov-17 Wit de LM Clinical Psychology VUmc 01-jan-15 Witting K Cell Biology II NKI 01-jul-12 Wolff HB Epidemiology and Biostatistics VUmc 01-mrt-15 Wollersheim B Psychosocial Research and Epidemiology NKI 21-aug-17 Wolters V MOD Gynaecology NKI 06-jun-17 Workum van FTWE Surgery VUmc 04-apr-16 Wortel R Radiotherapy NKI 01-mrt-14 Woude van der SO Internal Medicine Oncology AMC 01-okt-14 Woudstra AJ Social Medicine AMC 01-feb-14 Wubulikasimu A Clinical Epidemiology and Biostatistics VUmc 01-jan-09 Yalcin Z Molecular Oncology NKI 01-dec-12 Zaalberg A Oncogenomcis NKI 11-sep-17 Zaman ACGNM Coronel Institute AMC 01-aug-13 Zanden# van der S Cell Biology II NKI 01-jan-14 Zazuli Z Respiratory Medicine AMC 01-apr-17 Zecha JAEM Oral and Maxillofacial Surgery and Pathology VUmc 01-jan-13 Zee van der R Pathology / Infectious Diseases VUmc 15-dec-16 Zeijlemaker* W Hematology VUmc 01-dec-14 Zhang X Biomedical Engineering and Physics AMC 01-apr-14 Zhang L Center for Experimental and Molecular Medicine/CEMM AMC 16-okt-17 Zhang H Radiotherapy NKI 03-aug-09 Zhu Y Oncogenomics NKI 01-jul-16 Zuidema A Cell Biology I NKI 23-feb-15 Zummeren van M Pathology VUmc 01-sep-13 Zwart ES Surgery VUmc 01-sep-17 Zweeden van AA Medical Oncology VUmc 01-mrt-13

50 – PhD research program Oncology Graduate School Amsterdam OOA

Faculty and staff

annex 1

Annex 1. Faculty and staff

FACULTY Dr. J.A.M. Beliën, Department of Pathology, VUmc Prof. dr. Ing. M.C.G. Aalders, Department of (Theme 1). ICT and data analysis. Biomedical Engineering and Physics AMC (Theme 1). Tissue Spectroscopy, Spectroscopic Imaging, Prof. dr. W.A. Bemelman, Department of Surgery, Fluorescence Diagnostics and PhotoDynamic AMC (Theme 2). Colorectal and minimal invasive Therapy (PDT) of tumors. surgery

Prof. dr. N.K. Aaronson, Department of Prof. dr. T.K. van den Berg, Landsteiner Psychosocial Research and Epidemiology, NKI Laboratory, AMC (Theme 1). Phagocyte Biology (Theme 2). Behavioral interventions in clinical oncology and health-related quality of life Prof. dr. M.I. van Berge Henegouwen, assessment. Department of Surgery, AMC (Theme 2). Outcome Improvement in Esophago- Gastric Surgery. Prof. dr. R. Agami, Department of Oncogenomics,

NKI (Theme 1). Identifying and characterizing novel Dr. A. Bergman, Department of Molecular Genetics vulnerabilities of cancer NKI (Theme 1). The role of the microenvironment

in prostate carcinogenesis. Dr. L. Akkari, Department of Tumor Biology &

Immunology, NKI (Theme 1). Macrophage dynamics Prof. J.J.G.H.M. Bergman, Department of in Cancer Response to Treatment. Gastroenterology and Hepatology, AMC (Theme 2).

Detection and treatment of upper gastrointestinal Prof. dr. F.C.H. Amant, Department of Obstetrics cancer. and Gynecology, AMC (Theme 2). Cancer In

Pregnancy - Translational Research & Dr. J. Berkhof, Department of Epidemiology and Immunotherapy - Patient Derived Tumor Biostatistics, VUmc (Theme 1). Comparison self- Xenografts. collection of specimens for HPV testing with

physician-based HPV screening in a population- Prof. dr. J.T. Annema, Department of based screening setting. Pulmonology, AMC (Theme 2). Pulmonary

Endoscopy. Prof. dr. R. Bernards, Department of Molecular

Carcinogenesis, NKI (Theme 1). Functional Dr. J. Bakema, Department of genomics. Otolaryngology/Head and Neck Surgery, VUmc

(Theme 1). Molecular diagnosis and therapy of Prof. dr. A.J.M. Berns, Department of Molecular cancer and precursor lesions Head and Neck Genetics, NKI (Theme 1). Mouse models of cancer. Cancer. Dr. M.G.H. Besselink, Department of Surgery, AMC Prof. dr. A.J.M. Balm, Department of Oral and (Theme 2). Pancreatic and Hepato-Biliary Surgery. Maxillofacial Surgery, AMC (Theme 1). Head and neck oncology and surgery. Prof. dr. V.W. van Beusechem, Department of Oncology, VUmc (Theme 2). Therapeutic target Dr. R. Beijersbergen, Department of Molecular discovery by functional genetic screening and Carcinogenesis, NKI (Theme 1). Genotype specific Oncolytic immunotherapy. dependencies Dr. B.J. Biemond, Department Internal Medicine, Prof. dr. J.H. Beijnen, Division of Pharmacology, AMC (Theme 2). Coagulopathy in hematological NKI (Theme 2). Pharmaceutical Research drug malignancies. manufacturing - bioanalysis – pharmacokinetics. Dr. M.F. Bijlsma, Center of Experimental and Dr. A. Bel, Department of Radiotherapy, AMC Molecular Medicine, AMC (Theme 1). Biology (Theme 2). Innovative image guided radiotherapy. underlying the genesis, progression, and therapy resistance of pancreatic cancer.

Faculty and Staff - 53 Dr. A.D. Bins, Department of Medical Oncology, Dr. J. Cloos. Department of Hematology, VUmc AMC (Theme 2). Targeting the immune system (Theme 1) Alternative splicing (profiles) as towards cancer cells. targeted treatment of cancer.

Dr. C.U. Blank, Department of Molecular Dr. V.M.H. Coupé, Department of Epidemiology Oncology and Immunology, NKI (Theme 1 and 2). and biostatistics, VUmc (Theme 2). mathematical Combining targeted therapy and immunotherapy. modeling of the development and progression of cancer. Dr. E. Bleiker, Department of Psychosocial Research and Epidemiology, NKI (Theme 2). Dr. J. Crezee, Department of Radiation Oncology, Psychosocial oncology in clinical genetics and AMC (Theme 2). Hyperthermia. supportive care. Dr. M.R. Dahele, Department of Radiotherapy, Prof. dr. E. Bloemena, Department of Pathology, VUmc (Theme 2). Personalized treatment planning. VUmc (Theme 1 and 2). Molecular profiling of head & neck tumors. Prof. dr. E. Dekker, Department of Gastroenterology and Hepatology, AMC (Theme 1). Dr. A.G.E.M. de Boer, Coronel Institute of Colorectal polyps & cancer research. Occupational Health, AMC (Theme 2). Chronic disease and work. Prof. dr. J. Dekker, Department of Rehabilitation Medicine, VUmc (Theme 2). Behavioral factors in Prof. dr. H.J. Bonjer, Department of Surgery, somatic disease. VUmc (Theme 2). Minimally invasive surgery. Dr. I. van Die, Department of Molecular Cell Prof. dr. J.G. Borst, Department of Tumor Biology Biology and Immunology, VUmc (Theme 1). and Immunology, NKI (Theme 1). Molecular Glycobiological processes in relation to human mechanisms that govern the T-cell response. diseases.

Prof. dr. G. Bouma, Department of Prof. dr. G.A.M.S. van Dongen, Department of Gastroenterology, VUmc (Theme 2). Otolaryngology-Head & Neck Surgery, VUmc (Theme 1 and 2). Use of molecular imaging, Prof. dr. R.H. Brakenhoff, Department of especially PET and optical imaging, in the efficient Otolaryngology-Head & Neck Surgery, VUmc development, application and better understanding (Theme 1 and 2). Oncogenesis and cancer genes, of targeted drugs. prognostic modeling, molecular diagnosis, and identification of novel drug targets in head & neck Dr. N. van de Donk, Department of Hematology, cancer. VUmc (Theme 2). Immunotherapy strategies for multiple myeloma. Prof. dr. G.R. van den Brink, Tytgat Institute for Liver and Intestinal Disease, AMC (Theme 2), Dr. J.C. Dorsman, Department of Clinical Mechanisms that maintain a healthy colonic Genetics, VUmc (Theme 1). Distress and quality of epithelium and the way these are deregulated life of patients treated with autologous stem cell during development of colorectal cancer. transplantation.

Dr. T. Brummelkamp, Department of van Dulmen-den Broeder E, Department of Biochemistry, NKI (Theme 1). Experimental Pediatric Oncology, VUmc (Theme 2). Late effects Biomedical Genetics. of childhood cancer survivors.

Dr. L.M. Buffart, Department of Epidemiology and Dr. A.J.M. van den Eertwegh, Department of biostatistics, VUmc (Theme 2). Improvement of Medical Oncology, VUmc (Theme 2). quality of life and outcome of patients with cancer Immunotherapy for melanoma, prostate and renal via (multidisciplinary) exercise interventions. cancer patients.

Prof. dr. H. N. Caron, Department of Pediatric Prof. dr. M. van Egmond, Department of Molecular Oncology, AMC (Theme 1 and 2). Pediatric Cell Biology and Immunology, VUmc (Theme 1 and Oncology: biology and clinical. 2). The role of (chronic) inflammation in cancer development and s monoclonal antibody therapy of cancer.

Faculty and staff - 54 Prof. dr. M. A. Grootenhuis, Department of Dr. E.F. Eldering, Department of Experimental Pediatrics, AMC (Theme 2). Identify problems at an Immunology, AMC (Theme 1). Fundamental and early age and stage, and interventions to improve translational aspects in Immuno-Hematology. psychosocial functioning and quality of life.

Dr. W. Faller, Department of Molecular Genetics, Dr. J.W. Groothof JW, Department of Pediatrics, NKI (Theme 1), Unravelling the role of RNA AMC (Theme 2). End-stage renal disease in translation in cancer. children: quality of care and (long-term) outcome.

Prof. dr. P. Fockens, Dept. Of Gastroenterology Prof. dr. T.D. de Gruijl, Department of Medical and Hepatology, AMC (Theme 1). Advanced Oncology, VUmc (Theme 2). Immunotherapy and diagnostic and therapeutic gastrointestinal Immune monitoring. endoscopy, GI oncology and neuro gastroenterology. Prof. dr. T.M. van Gulik, Department of Experimental Surgery, AMC (Theme 2). Dr. N.A.P. Franken, Department of Radiotherapy, Experimental surgery on colon cancer liver AMC (Theme 2). Radiobiology, DNA damage metastases. response, hyperthermia, chromosome aberrations, normal tissue damage. Den Haan JMM, Department of Molecular Cell Biology and Immunology, VUmc (Theme 1). Prof. dr. M.H.W. Frings-Dresen, Coronel Institute Myeloid cells in Adaptive Immunity. of Occupational Health, AMC (Theme 2) Occupational Diseases; Etiology and prevention of Dr. J. Haanen, Department of Molecular Oncology work-related diseases. and Immunology and Medical Oncology NKI (Theme 1 and 2). Immunotherapy, immunomonitoring and Garcia-Vallejo JJ, Department of Molecular Cell production facility. Biology and Immunology, VUmc (Theme 1). The implementation of analytical and biocomputational Prof. dr. W. Van Harten, Department of methods to identify biomarkers that can predict Psychosocial Research and Epidemiology, NKI the response of cancer patients to immunotherapy. (Theme 2). Early stage technology assessment, operations research and cancer rehabilitation. Prof. dr. S. Gibbs, Department of Dermatology, VUmc (Theme 1), Tissue engineering, skin, wound Dr. M. Hauptmann, Department of Psychosocial healing, in vitro assays. Research and Epidemiology, NKI (Theme 2). Biostatistics. Dr. E. Giovannetti Department of Medical Oncology, VUmc (Theme 2). Mechanism of action, Dr. M.D. Hazenberg, Department of Internal toxicity and efficacy of anticancer agents & clinical medicine, AMC (Theme 2). Innate and adaptive pharmacology of chemotherapeutic drugs. immunity following allogeneic hematopoietic stem cell transplantation. Dr. P. de Graaf, Department Radiology and Nuclear Medicine, VUmc (Theme 2). Dr. M. Heger, Department of Surgery, AMC (Theme Neuroradiology and Head & Neck radiology. 1). Development of therapeutic modalities for recalcitrant solid cancers. Dr. N.C.T. van Grieken, Department of Pathology, VUmc (Theme 2). Genetic changes is gastro- Dr. D.A.M. Heideman, Department of Pathology, intestinal tumors and personalized therapy. VUmc (Theme 1). Genomic profiling for risk assessment of preneoplastic endobronchial lesions. Prof. dr. A.W. Griffioen, Department of Medical Oncology, VUmc (Theme 2). Tumor angiogenesis Dr. U. van der Heide, Department of Radiation and drug therapy. Oncology, NKI (Theme 2). Imaging technology in radiation oncology. Dr. R.W.J. Groen, Department of Hematology, VUmc (Theme 1). Bidirectional interaction of Prof. dr. N.H. Hendrikse, Department of tumors cells and the bone marrow Pharmacy, VUmc (Theme 2). Image guided microenvironment. treatment optimalization with cetuximab for patients with metastatic colorectal cancer.

Faculty and staff - 55 Dr. J. Hilkens. Department of Molecular Genetics, Prof. dr. G.J. Kaspers, Department of Pediatrics, NKI (Theme 1). Genes involved in breast cancer. VUmc (Theme 2). Innovative therapies in childhood myeloid leukemia. Prof. dr. O.S. Hoekstra, Department of Nuclear Medicine, VUmc (Theme 2). Molecular imaging Prof. dr. A.P. Kater, Department of Hematology, using PET for therapy selection and response AMC (Theme 1 and 2). Immune)biology and monitoring. treatment of B-cell malignancies with chronic lymphocytic leukemia (CLL). Dr. J.E. van Hooft, Department of Gastroenterology and Hepatology, AMC (Theme 2). Prof. dr. G. Kazemier, Department of Surgery, Innovative Gastrointestinal Endoscopy. VUmc (Theme 2). Fighting pancreatic cancer: from research to innovative treatment through Dr. E. Hulleman, Department of Pediatric microRNA analysis. Oncology, VUmc (Theme 1 and 2). Novel treatment modalities for pediatric brain tumors. Prof. dr. G.G. Kenter, Department of Obstetrics and Gynecology, AMC/VUmc/NKI (Theme 2). Dr. H. Jacobs, department of Tumor Biology and Immunosurveillance and immunotherapy in HPV Immunology, NKI )Theme 1. Programmed and non- related tumors and late complications after programmed mutagenesis. treatment for carcinoma of the cervix.

Dr. J. Jacobs, Department of Oncogenomics, NKI Prof. dr. M.J. Kersten, Department of (Theme 1). Telomere and genome integrity. Hematology, AMC (Theme 1). Biology and treatment of lymphoma. Prof. dr. K. Jalink, Department of Cell Biology, NKI (Theme 1). Biophysics of cell Signaling. Prof. dr. M. Klein, Department of Medical Psychology, VUmc (Theme 2). Improving quality of Dr. J.J.W.M. Janssen, Department of Hematology, life in glioma patients. VUmc (Theme 2). Targeted therapy for Acute and Chronic Myeloid Leukemia. Dr. H.J. Klümpen HJ, Department of Medical Oncology, AMC (Theme 2). Rare gastrointestinal Prof. dr. C.R. Jimenez, Department of Oncology, (GI) malignancies such as hepatocellular carcinoma VUmc (Theme 2). Innovative mass spectrometry- (HCC), cholangiocarcinoma and neuroendocrine based (phospho)proteomics and data analysis to tumors/carcinomas. improve (early) diagnostics and treatment of cancer. Prof. dr. J.A. Knoop, Department of Medical Psychology, AMC (Theme 2). Evidence-based Prof. dr. D. de Jong, Department of Pathology, behavioral interventions for medical conditions and VUmc (Theme 1). Towards the implementation of somatic symptoms. personalized treatment of diffuse large B-cell lymphoma in the Netherlands; preparations for a Prof. dr. Y. van Kooyk, Department of Molecular biomarker-based Bayesian trial. Biology and Immunology, VUmc (Theme 1 and 2). Glycosylation and tumor immunology. Prof. dr. J. Jonkers, Department of Molecular Pathology, NKI (Theme 1). Mouse models of breast Dr. L.C.M. Kremer, Department of Pediatrics, AMC cancer. (Theme 1). Evidence based medicine & quality of care long-term effects of childhood cancer. Dr. E.S. Jordanova, Department of Obstetrics and Gynecology, AMC/VUmc/NKI (Theme 1 and 2). Prof. dr. K.K. Krishnadath, Department of Immunological background of various virally Gastroenterology and Hepatology, AMC (Theme 1). induced cancer types, such as vulvar-, cervical, Understanding the inflammation-dysplasia- head-and-neck and penile cancer. carcinoma sequence within the gastrointestinal tract. Prof. dr. A.H.C. van Kampen, Department of Clinical Epidemiology, AMC (Theme 1). Prof. dr. C. van Kuijk, Department of Radiology Bioinformatics methods for analysis of omics data. and Nuclear Medicine, VUmc (Theme 2). Irreversible electroporation: a novel image-guided tumor ablation technique.

Faculty and staff - 56 Dr. A.B.P. van Kuilenburg, Department of Clinical Prof. dr. A.A. van de Loosdrecht, Department of Chemistry, AMC (Theme 1 and 2). Inborn errors of Hematology, VUmc (Theme 2). Dendritic cells and purine and pyrimidine metabolism and pediatric antigen sources in acute myeloid leukemia. oncological diseases. Prof. dr. R.M. Luiten, Department of Dr. P. Kvistborg, Department of Molecular Dermatology, AMC (Theme 2). Clinical and Oncology & Immunology, NKI (Theme 1). The aim experimental research on pigment cells and of our research is to dissect the tumorspecific T- pigment disorders in order to understand the cell response. pathogenesis and improve treatment of these diseases. Prof. dr. H.W.M. van Laarhoven, Department of Internal Medicine. AMC (Theme 1). Bridging Prof. dr. R.E. Mebius, Department of Molecular preclinical and clinical approaches, to improve Cell Biology and Immunology, VUmc (Theme 1). cancer treatment as well prediction of response to Functional development of the immune system. treatment, based on insights in tumor biology and improvement of quality of life in oncological Prof. dr. J.P. Medema, Laboratory of patients. Experimental Oncology and Radiobiology, AMC (Theme 1). Cell death induction and resistance in Dr. F.J. Lagerwaard FJ, Department of tumor cells and cancer stem cells. Radiotherapy, VUmc (Theme 2), Radiotherapy of brain tumors, stereotactic radiosurgery. Prof. dr. R.H. Medema, Department of Cell Biology, NKI (Theme 1). Cell cycle checkpoints and Prof. dr. M.P. Laguna Pes, Department of Urology, chromosome segregation. AMC (Theme 2). Oncological Urology Prof. dr. G.A. Meijer, Department of Diagnostic Prof. dr. Ch. R. Leemans, Department of Oncology, NKI (Theme 1 and 2). Translational Otolaryngology-Head & Neck Surgery, VUmc Gastrointestinal Oncology. (Theme 2). Molecular mechanisms in precursor lesions and early stages of head & neck cancer for Dr. M.R. Meijerink, Department Radiology and early detection. Nuclear Medicine, VUmc (Theme 2). Image-guided therapies for cancer. Prof. dr. A.G.J.M. van Leeuwen, LaserCenter, AMC (Theme 2). Physics of the interaction of light Prof. dr. H. Meijers-Heijboer, Department of with tissue for the development, introduction and Clinical Genetics, AMC/VUmc (Theme 1). a) clinical evaluation of optical imaging and analysis inherited cancer syndromes; b) development of techniques for gathering quantitative functional genetic services in clinical care and the general and molecular information of tissue or tissue population. sample. Prof. dr. W.H. Moolenaar, Department of Cell Prof. dr. F.E. van Leeuwen, Psychosocial Biology, NKI (Theme 1). Lipid growth factor Research and Epidemiology, NKI (Theme 2). Cancer signalling. Epidemiology. Prof. dr. A.C. Moll, Department of Dr. F. van Leeuwen, Department of Gene Opthalmonology, VUmc (Theme 2). Early-detection Regulation, NKI (Theme 1). Chromatin dynamics. of quality of life problems in children with retinoblastoma. Dr. T. Lenstra, Department of Gene Regulation, NKI (Theme 1), Transcription dynamics Prof. dr. R.J.A. van Moorselaar, Department of Urology, VUmc (Theme 2). Urological oncology. Prof. dr. S. Linn, Department of Molecular Pathology, NKI (Theme 2). Molecular dissection of Dr. T. Mutis, Department of Hematology, VUmc cancer by differential drug sensitivity. (Theme 2). Multimodal imaging of orthotropic tumors. Prof. dr. M. van Lohuizen, Department of Molecular Genetics, NKI (Theme 1). Role of Dr. R. Nieuwland, Laboratory for Experimental polycomb-group genes in transcriptional Clinical Chemistry, AMC (Theme 1). Extracellular repression, stem cell fate and tumorgenesis. vesicles and platelets in health and disease.

Faculty and staff - 57 Prof. dr. C.J.M. van Noesel, Department of in gastrointestinal cancer, with focus on colorectal Pathology, AMC (Theme 1). B cell biology and the cancer. pathogenesis of B-NHL / The serrated neoplasia pathway to colorectal cancer. Prof. dr. C.R.N. Rasch, Department of Radiotherapy, AMC (Theme 1). Image guided and Prof. dr. C.J.F. van Noorden, Department of physics application in the clinic. Pathology, AMC (Theme 1). Cancer metabolism. Dr. T.M. de Reijke, Department of Urology, AMC Dr. D.P. Noske, Department of Neurosurgery, (Theme 2) prostate cancer and bladder cancer VUmc (Theme 2). identification of novel molecules diagnostics. that can be used as markers/targets for the development of new therapeutic approaches for Dr. J.C. Reijneveld, Department of Neurology, brain tumors. VUmc (Theme 2). Cognitive disturbances, epilepsy, and quality- and end-of-life issues in patients with Prof. dr. M.H.J. van Oers, Department of Clinical primary brain tumors. Hematology, AMC (Theme 2). Pathogenesis and (immuno)therapy of B cell malignancies. Dr. J. van Rheenen, Department of Molecular Pathology, NKI (Theme 1), Intravital microscopy of Dr. M.G.H. van Oijen, Department of Medical cancer plasticity. Oncology, AMC (Theme 2). Improving the quality of cancer care by forming and analyzing large Prof. dr. H.P.J. te Riele, Department of Tumor datasets, combined with state of the art Biology & Immunology, NKI (Theme 1). Genomic information technology, including decision support instability and carcinogenesis. tools and wearable technology. Prof. dr. J.J.M.C.H. de la Rosette, Department of Prof. dr. G.J. Ossenkoppele, Department of Urology, AMC (Theme 2). Minimal invasive urology Hematology, VUmc (Theme 1 and 2). Targeted and oncological urology. therapies in myeloid leukemia. Dr. S. Rottenberg, Department of Molecular Prof. dr. S.T. Pals, Department of Pathology, AMC Pathology, NKI (Theme 1). Therapy escape of (Theme 1 and 2). B-cell development and cancer. neoplasia. Dr. B. Rowland, department of Gene Regulation, Prof. dr. D.L. van der Peet, Department of NKI (Theme 1), Chromosome biology. Surgery, VUmc (Theme 2). Upper GI surgery. Prof. dr. T. Ruers, Department of Surgical Dr. D.M. Pegtel, Department of Pathology, VUmc Oncology, NKI (Theme 2). (Theme 1). Tumor exosomes biology and the microenvironment, exosomes and small non-coding Dr. S. Schagen, Department of Psychosocial RNAs & liquid biopsy. Research and Epidemiology, NKI (Theme 2). Cognitive function in cancer patients. Prof. dr. D. Peeper, Department of Molecular Oncology & Immunology. NKI (Theme 1). Functional Prof. dr. J.H.M. Schellens, Department of oncogenomics for cancer drug target discovery. Molecular Pathology, NKI (Theme 2). Pharmacodynamics of anti cancer drugs. Dr. A. Perrakis, Department of Biochemistry, NKI (Theme 1). Structural biology. Dr. A. Schinkel, Department of Molecular Oncology, NKI (Theme 1). Genes and proteins Prof. dr. G.J. Peters, Department of Clinical involved in anticancer drug resistance and Oncology, VUmc (Theme 2). Pharmacokinetics and pharmacokinetics. response prediction in oncology. Dr. M. Schmidt, Department of Molecular Dr. L.V. van de Poll-Franse, Department of Pathology, NKI (Theme 1). Molecular breast cancer Psychosocial Research and Epidemiology, NKI epidemiology. (Theme 2). Cancer survivorship. Prof. dr. T. Schumacher, Department of Molecular Prof. dr. C.J.A. Punt, Department of Oncology, Oncology & Immunology, NKI (Theme 1). Dissection AMC (Theme 1). Clinical and translational research and manipulating antigen-specific T-cell immunity.

Faculty and staff - 58

Prof. dr. S. Senan, Department of Radiation Dr. R.D.M. van Steenbergen. Department of Oncology, VUmc (Theme 2). Technological Pathology, VUmc (Theme 1). Biology of human innovations in applied radiotherapy. papillomavirus (HPV)-induced carcinogenesis and molecular testing of HPV. Prof. dr. T.K. Sixma, Department of Biochemistry, NKI (Theme 1). Structural biology. Prof. dr. B. van Steensel, Department of Gene Regulation, NKI (Theme1). Chromation genomics. Dr. J-J. Sonke, Department of Radiation Oncology, NKI (Theme 2). Adaptive radiation therapy. Prof. dr. ir. H.J.C.M. Sterenborg, Department of Biomedical Engineering and Physics, AMC (Theme Prof. dr. A. Sonnenberg, Department of Cell 1). Optical techniques for diagnosis of disease and Biology, NKI (Theme 1). Receptors for matrix monitorring of treatment. adhesion. Prof. dr. J. Stoker, Department of Radiotherapy, Prof. dr. B.J. Slotman, Department of Radiation AMC (Theme 1). Abdominal imaging. Oncology, VUmc (Theme 1 and 2). Technological innovations in applied radiotherapy. Dr. M. Stokkel, Department of Diagnostic Oncology, NKI (Theme 2). Nuclear medicine. Dr. P. Sminia. Department of Radiation Oncology, VUmc (Theme 1). Local delivery of radionuclides Dr. ir. G.J. Strijkers, Department of Biomedical and/or targeted agents. Engineering and Physics, AMC (Theme 1). Preclinical and translational MRI. Prof. dr. E.F. Smit, Department of Pulmonology, VUmc (Theme 2). Targeted drug therapy in lung Prof. dr. E.L Swart, Department of Pharmacology, cancer. VUmc (Theme 2). Pharmacokinetic en pharmacodynamic proporties of anti-cancer drugs. Dr. L. Smit, Department of Hematology, VUmc (Theme 1). Leukemic stem cell (LSC) in acute Dr. P.J. Tanis, Department of Surgery, AMC myeloid leukemia (AML). (Theme 2). Colorectal cancer; Complications after pelvic surgery. Prof. dr. P.J.F. Snijders, Department of Pathology, VUmc (Theme 1). HPV induced tumors. Dr. O.van Tellingen, Department of Pharmacology, NKI (Theme 1). Pre-clinical studies to evaluate Dr. M. Spaargaren, Department of Pathology, AMC novel treatments for glioblastoma. (Theme 1). Molecular pathogenesis and targeted therapy of B cell malignancies. Thijssen VLJL, Department of Medical Oncology, VUmc (Theme 1 and 2). Interaction between Dr. C.A. Spek, Department of Experimental and angiogenesis inhibition and radiotherapy. Molecular Medicine, AMC (Theme 1 and 2). Blood coagulation in pathophysiology. Dr. H. van Tinteren, Department of Biometrics, NKI (Theme 2). Clinical Trials design and logistics. Prof. dr. H. Spits, Department of Cell Biology and Histology, AMC (Theme 1). Biology of innate Dr. M.P. van den Tol, Department of Surgery, lymphoid cells which are important regulators and VUmc (Theme 2). Image-guided local surgery and effectors of tissue immunity, homeostasis ablative surgery of colorectal liver metastasis and remodeling and repair. mamma carcinoma.

Prof. dr. M.A.G. Sprangers, Department of Dr. G.A.M. Tytgat, Department of Pediatrics, AMC Medical Psychology, AMC (Theme 2). Enhance the (Theme 2). Translational investigations in well-being of somatically ill patients by studying childhood solid tumors (neuroblastoma, renal their quality of life and to facilitate the correct tumors). inclusion of patient-reported outcomes in patient- based, clinical research. Prof. dr. W.P. Vandertop, Department of Neurosurgery, VUmc (Theme 2). Meningioma. Prof. dr. L.J.A. Stalpers, Department of Radiotherapy, AMC (Theme 1). Translational radiotherapy in patients with pelvic tumors.

Faculty and staff - 59 Dr. Ir. W.F.A.R. Verbakel, Department of Dr. D. Vugts, Department of Radiology and Nuclear Radiation Oncology, VUmc (Theme 2). Medicine, VUmc (Theme 2). pre-targeted imaging, Implementation of new types of radiation preclinical and clinical immuno-PET imaging and treatment, quality control and difficult development of 18F radiochemistry methods. treatments. Prof. dr. H.C.P.M van Weert, Department of Prof. dr. I.M. Verdonck-de Leeuw, Department of General Practice, AMC (Theme 2). Diagnostic Otolaryngology/Head and Neck Surgery, VUmc decision support and care for chronically ill (Theme 2). Quality of life issues and psychosocial patients in general practice. oncology in (head and neck) cancer patients and to assess (cost-) effectiveness of supportive cancer Prof. dr. J. Wesseling, Department of Molecular care. Pathology, NKI (Theme 1). Molecular pathology of breast cancer. Prof. Dr. M. Verheij, Department of Biological Stress Response and Radiation Oncology, NKI Prof. dr. P. Wesseling, Department of Pathology, (Theme 2). Targeted radiosensitization. VUmc (Theme 2). Classification and therapy of central nervous system tumors. Prof. dr. H.W.M Verheul, Department of Medical Oncology, VUmc (Theme 1 and 2). Personalized Prof. dr. L. Wessels, Department of Molecular therapy in gastrointestinal and renal cancer. Carcinogenesis, NKI (Theme 1). Computational cancer biology. Dr. L. Vermeulen, Center of experimental medicine. AMC (theme 1). Quantitative approaches Prof. dr. M.A. van de Wiel, Department of in combination with state of the art in vitro and in Epidemiology and Biostatistics, VUmc (Theme 1). vivo models to study the biology of intestinal statistics for high-dimensional data, which is aimed cancers in order to improve tumor classification at solving problems that arise from genomics. and therapies. Prof. dr. H. Wijkstra, Department of Urology, AMC Prof. dr. R. Versteeg, Department of Human (Theme 2). Minimal invasive technology in Genetics, AMC (Theme 1 and 2). Regulatory diagnoses, therapy and follow-up of uro-oncology. networks in cancer. Dr. J.W. Wilmink, Department of Medical Prof. dr. M. van de Vijver, Department of Oncology, AMC (Theme 2). Upper gastro-intestinal Pathology, AMC (Theme 1). Genetic alterations and oncology & breast cancer. gene expression profiles of solid tumors. Prof. dr. A.D. Windhorst, Department of Radiology Dr. K. de Visser, Department of Tumor Biology and and Nuclear Medicine, VUmc (Theme 2). Carbon-11 Immunology, NKI (Theme 1). Impact of the immune labelled peptides as PET tracers. system on metastatic breast cancer and therapy response. Dr. E. de Wit, Department Gene Regulation, NKI (Theme 1). Genome function and dynamics. Dr. J.J van Vliet, Department of Medical Oncology, VUmc (Theme 2). Antitumor Immunity. Dr. P.C. de Witt Hamer, Department of Neurosurgery, VUmc (Theme 2). Functional brain Dr. S.J. van Vliet, Department of Molecular Cell tumor surgery. Biology and Immunology, VUmc (Theme 1). Interaction between lectin receptors and their Dr. R.M.F. Wolthuis, Department of Clinical cancer-associated glycan ligands, in immune Genetics, VUmc (Theme 1). Cancer predispositions evasion during cancer progression. at basic mechanistic, translational and diagnostic levels. Prof. dr. E. Voest, Department of Molecular Oncology and Immunology, NKI (Theme 1 and 2). Prof. dr. T. Wurdinger, Department of Personalized Medicine by employing tumor Neurosurgery, VUmc (Theme 1). Blood platelet- organoids and genomics. based monitoring and cancer treatment optimalization. Dr. J. Voortman, Department of Medical Oncology, VUmc (Theme 2). Treatment of Head and neck cancer and urological tumors.

Faculty and staff - 60 Prof. dr. B. Ylstra. Department of Pathology, VUmc (Theme 1). Comparative analysis of molecular markers in liquid biopsies and tissue samples of cancer patients.

Dr. J.M. Zijlstra-Baalbergen, Department of Hematology, VUmc (Theme 2). PET response monitoring in malignant lymphoma and multiple myeloma.

Dr. C. Zuur, Department of Tumor Biology and Immunology, NKI (Theme 1 and 2). Improvement treatment responses in Head and Neck Cancer.

Dr. W. Zwart, Department of Oncogenomics, NKI (Theme 1). Hormone receptors in cancer.

Prof. dr. S. Zweegman, Department of Hematology, VUmc (Theme 2). Diagnostics and treatment of multiple myeloma.

Faculty and staff - 61 STAFF Public Health AMC, University of Amsterdam Dr. M.P. Fransen

Biomedical Engineering and Physics Radiation oncology Coolen BF Bijker N Faber DJ Dieleman EMT Geijsen ED Biothechnology Kolff MW Priyan V Pieters BR van Tienhoven G Cell Biology and Histology Visser J Pos W Westerveld GH Reits E Hinnen KA Koedooder C Dermatology Oldenburger F Bekkenk MW Tutein Nolthenius CJ Bakker WJ van der Klis KAM van Kesteren Z Gastroenterology and Hepatology van Wieringen N Takkenberg RB Wiersma J Tytgat KMAJ Beuers UHW Radiology Smout AJPM Bennink RJ Bipat S Hematology Tonino SH Social Medicine van Asselt KM Medical Oncology van Dijk N Bins AD Fransen MP

Medical Psychology Surgery Smets EMA Busch OR Maurice-Stam H Nieveen van Dijkum EJM

Obstretics and Gynaecology Urology Buist MR Gerbrandy-Schreuders LC van Lonkhuijzen LRCW Joosten EAHM van der Velden JH Kamphuis GM Meissner A Oncogenetics Zondervan PJ Koster JJB Valentijn LJ

Ophthalmology Klaassen I Schlingemann RO

Oral and Maxillofacial Surgery Smeele LE

Pathology Koens L Meijer SL Verheij J

Pulmonology Veltman JD

Faculty and staff - 62 Netherlands Cancer Institute dr. A. Schinkel Dr. O. van Tellingen Biochemistry Dr. T. Brummelkamp Molecular Oncology & Immunology Prof. dr. W.H. W. Moolenaar Prof.dr. C. Blank Dr. A. Perrakis Dr.P.Kvistborg Prof. dr. T.K. Sixma Prof.dr.D.S. Peeper Prof.dr. T. Schumacher Cell Biology Prof.dr. E.E. Voest Dr. G.Borst Dr. C. Jalink Prof. dr. R.H. Medema Biometrics Department Prof. dr. A. Sonnenberg Dr. V. van der Noort Prof. dr M.Verheij Dr. K. Sikorska Dr. H. Van Tinteren Gene Regulation Dr. H. Thygesen Dr. F. van Leeuwen E. van Werkhoven Dr. T. Lenstra Dr. M. Lopez Yurda Prof. dr. B. van Steensel Dr. E. de Wit Diagnostic Oncology M. Almekinders Tumor Biology & Immunology P. Baars Dr. L. Akkari Dr. R. Beets-Tan Dr. C.H. Blank Dr. J. van den Berg Prof. dr. J. Borst Dr. E. Bleiker Dr. H. Jacobs Dr. M. Bol Dr. K.E. de Visser Dr H. van Boven Dr. C. Zuur Dr. D. van den Broek Dr. A. Broeks Molecular Carcinogenesis Dr. B. Carvalho Prof. dr. R. Bernards Dr. J. van Denderen Dr. R. Beijersbergen M. Donswijk Dr. M. van der Heijden Dr. R. Fijneman Prof. dr. L. Wessels E. Groen D. Hahn Molecular Genetics B. van der Hiel Prof. dr. A.J.M. Berns Dr. F. Hogervorst Dr. W.Faller Dr. E. Hooijberg Prof. dr. M. van Lohuizen Dr. H. Horlings M. Jonker Oncogenetics Dr.L. van der Kolk Dr. A. Bergman Dr. T. Korse Prof. dr. P. Borst (honorary staff member) M. Lahaye Dr. J.J.L. Jacobs Dr. D. Lambregts Dr. H. van Luenen Dr. M. Maas Dr. W. Swart Prof. Dr. G. Meijer Dr. F. Menko Molecular Pathology Dr. K. Monkhorst Prof. dr. J. Jonkers Dr. S. Muller Dr. S. Linn Dr. P. Nederlof Prof.dr. J. van Rheenen K. van Os Dr. S. Rottenberg Dr. M. Ruijs Dr. M. Schmidt Dr. E. Rosenberg Dr. J. Wesseling J. Sanders F. Sivro-Prndeij Pharmacology Dr. L. Smit Prof.dr.J.Schellens P. Snaebjornsson Prof.dr. J.Beijnen Dr. M. Stokkel

Faculty and staff - 63 Dr. R. Valdes Olmes Dr. A. Bergman Dr. E. Vegt Prof. dr. J.H. Beijnen Dr. M. Versleijen Dr. C. Blank Dr. K. van de Vijver Dr. J.P. de Boer Dr. J. van der Wal Dr. W. Boogerd Dr. M. Vogel Dr. H. Boot Dr. W. Vogel Dr. D. Brandsma Dr. J. Wesseling Dr. W. Buikhuisen B. van de Wiel Dr. J.A.. Burgers Dr. L. de Wit-van der Veen Dr. A. Cats M. Chalabi Radiotherapy Dr. J. van Dieren Dr. B.M.P. Aleman Dr. R. van Gijn Dr. A. Abrahim Al-Mamgani Dr. C. Grootscholten Prof. dr. G.M.M. Bartelink Dr. J.B.A.G. Haanen Dr. J.S.A. Belderbos Dr. M. van der Heijden Dr. M. Bloemers Dr. M van den Heuvel Dr. G. Borst Dr. A. Huitema Dr. E. Damen Dr. W. de Kanter Dr. L.G.H. Dewit Dr. J.M. Kerst J. van Diessen M. Kok Dr. P. Elkhuizen Dr. M. van Leerdam Dr. M. Frantzen-Steneker Prof. dr. S.C. Linn Dr. R.L.M. Haas Dr. S. Marchetti O. Hamming-Vrieze Dr. B. Nuijen Dr. W. Heemsbergen F. Opdam Dr. U. Van der Heide Prof. dr. S. Rodenhuis Prof. dr. M. van Herk Prof. dr. J.H.M. Schellens Dr. E.P.M. Jansen Dr. E. Smit Dr. J. Van de Kamer Dr. C. Smorenburg J. Knegjens Dr. G. Sonke F. Koetsveld Dr. N. Steeghs Dr. J. Lebesque Dr. J. Stouthard Dr. A. Mans Dr. M Tesselaar Dr. B.J. Mijnheer Dr. H. Van Thienen Dr. L.M.F. Moonen Dr. W. Verbeek Dr. A. van Mourik Prof. Dr. E. Voest A. Navran Q. de Waard H. Peulen Dr. F. Pos Surgical Oncology Dr. P. Remeijer A. Aalbers Dr. N.S. Russell Dr. A. van Akkooi J.G. Salverda C. Van As-Brooks Dr. C. Schneider Dr. M-J. Baas-Vracken Peters Dr. A. Scholten Dr. A. Balm Dr. J-J. Sonke Dr. G. Beets Dr. B. van Triest Dr. M.W.M. van den Brekel Dr. C.X. Vens Dr. F. van Coevorden Prof. dr. M. Verheij Dr. F. van Duijnhoven Dr. C. van Vliet-Vroegindeweij Dr. J. van der Hage F. Voncken Dr. K. Hartemink T. Wiersma Dr. F. Hilgers T. Witteveen Dr. B. Karakullukcu Dr. F.W. Wittkämper Dr. H. Klomp Dr. M. Klop Medical Oncology N. Kok Dr. J.W. Baars M. Krap Dr. P. Baas Dr. K. Kuhlmann

Faculty and staff - 64 M. Lieshout Dr. P. Lohuis Dr. H.S.A. Oldenburg M. Piek-den Hartog Prof. dr. T. Ruers Dr. E.J.Th. Rutgers Dr. J. van Sandick P. Schreuder Dr. L. Smeele Dr. B. Tan Dr. B. Tijink L. van der Velden Dr. M. Wouters Dr. C. Zuur

Psychosocial Research and Epidemiology Prof. dr. N.K. Aaronson Dr. E. Bleiker Prof. dr. W.J. van Harten Dr. M. Hauptmann Prof. dr. F.E. van Leeuwen Dr. L.V. van de Poll-Franse Dr. M.A. Rookus Dr. S. Schagen

Faculty and staff - 65 VU University Medical Center Richir M van Dam EWCM Anatomy and Neuroscience Witvliet-van Nierop JE Douw L Kramer MHH Drukarch B Geurts JJ Medical Oncology Hulst HE Buffart TE Wilhelmus MMM Buter J Gootjes EC Anesthesiology Konings IRHM Huisman BAA van der Vorst MJDL Schober P van Linde ME Zuurmond WWA van der Houven van Oordt CW

Clinical Chemistry Medical Psychology Bontkes H Brewaeys M Dommering CJ Hilverda-Hooijboer K Salomons GS Snoep L Teunissen CE van der Linden MHM van Dijk EM Clinical Genetics Henneman L Metamedica Houweling A Widdershoven GAM Joenje H van de Vrugt HJ Molecular Celbiology and Immunology van Hest LP de Vries HE van Swieten JC Neurology Clinical Pharmacology Heimans JJ Hugtenburg JG Kouwenhoven MCM Bet PM Niers A Postma TJ Dermatology Pijnenburg YAL Hoekzema R Uitdehaag BMJ van Thuijl HF Epidemiology and Biostatistics de Lange-De Klerk ES Neurosurgery de Vet HCW Hoefnagels F Heijmans MW Baayen JC Ostelo RWJG Idema S Terwee CB Koppers-Lalic D Twisk JWR Peerdeman SM van de Ven P de Menezes R Obstetrics and Gynaecology Jonker MA Lambalk CB van Wieringen WN Mom C Trum JW Hematology Verhoef VMJ Chamuleau MED Dijkstra MG Lokhorst HM Schreurs AMF Meijer E Spruijt JWM Wondergem MJ Uijterwaal MH Martens ACM Schuurhuis GJ Ophthalmonology Hartong DT Internal Medicine Tan H Alhan C Nijhof I

Faculty and staff - 66 Oral and Maxillofacial Surgery and Pathology Mullender MG Baart JA Özer M de Visscher JGAM Forouzanfar T Psychiatry Karagozoglu KH Beekman ATF Leusink F Eeckhout AM Schulten EAJM van Oppen P

Otolaryngology/Head and Neck Surgery Pulmonology Hendrickx JJ Bahce I Heuveling D Becker A Rietbergen MM Daniels JMA Rinkel RNPM de Langen AJ van Gogh CDL Hashemi SMS Nossent EJ Pathology Lind J Hoozemans J Vonk-Noordegraaf A Neefjes-Borst E Uyterlinde AM Radiation Oncology Beliën JAM Bohoudi O Bugiani M Bruynzeel AME Cillessen SAGM de Haan PF Meijer CJLM Haasbeek CJ Mooi WJ Rietveld DHF Scheper RJ Spoelstra FOB Thunnissen FBJM Vergeer MR van der Valk P Wesseling P Radiology & Nuclear Medicine Boellaard R Pediatric Oncology Castelijns J Abbink F Comans EFI Gemke RJBJ de Vries J Jansen MHA Lammertsma AA Kors WA Oprea-Lager D Mostert SM Sanchez Aliaga E van den Berg MH van Berckel BN van Litsenburg R van Lingen A de Meij TGJ van Waesberghe JHTM Haarman EG Barkhof F Wolf NI Bot J Duvivier KM Pediatric Surgery Kist J van Heurn LWE Molthoff CFM van der Steeg AFW Poot AJ Raijmakers PG Pharmacy van den Bergh JE Wilhelm AJ Verbeke JIML Visser GWM Physics and Medical Technology Pouwels PJW Rehabilitation Medicine de Goede CJ Physiology Geleijn E Musters RJP Social Medicine Plastic, reconstructive and handsurgery Francke AL Krekel-Taminiau NMA Philipsen-Onwuteaka B Bouman MB Timmermans DRM Buncamper ME van Mechelen W

Faculty and staff - 67 Wagner C Surgery Borstlap WAA Daams F Wijsmuller A Zonderhuis B

Urology Meuleman EJH Nieuwenhuijzen JA Vis A

Faculty and staff - 68 Oncology Graduate School Amsterdam OOA

International visitors

annex 2

Annex 2. International visitors

Amon, Angelika. MIT, USA Leusden, Jeanette. UMC Utrecht, the Netherlands Ashby, Meredith. Pacific Biosciences of California, Inc, USA Malanchi, Ilaria. The Francis Crick Institute, UK van Attikum, Haico. University of Geneva, Mellor, Jane. University of Oxford, UK Switzerland Mills, Gordon. MD Anderson Cancer Center, USA Mulder, Klaas. RadboudMC, The Netherlands Belmont, Andrew. University of Illinois, USA Mummery, Christine. LUMC, The Netherlands Brinton, Louise. National Cancer Institute, USA Murre, Cornelis. University of California, USA

Chao, Jeffrey, Friedrich Miescher Institute, Preston, Dale. Hirosoft International, Japan Germany Prokosch, Hans-Ulrich. Friedrich-Alexander- Clevers, Hans. Princess Maxima Center and Universität, Germany Hubrecht Institute, the Netherlands Coyne, James C. University of Pennsylvania, USA Rajewsky, Nikolaus. Max Delbrück Center, Germany Dermitzakis, Emmanouil. University of Geneva, Ringhausen, Ino. University of Cambridge, UK Switzerland Dive, Caroline. Cancer Research UK Manchester Sale, Julian. MRC Laboratory of Molecular Biology, Institute, UK UK Dixit, Vishva. Genentech, USA Sharan, Shyam. National Cancer Institute, USA Soutoglou, Evi. L'institut de génétique et de Engelhardt, Britta. University of Bern, Switzerland biologie moléculaire et cellulaire, France

Friedman, Nir. The Hebrew University of Teichmann, Sarah. Wellcome Sanger Institute, UK Jerusalem, Israel Furlong, Eileen. EMBL Heidelberg, Germany Valerius, Thomas. Christian-Albrechts University, Germany Kaempfer, Raymond. The Hebrew University of Verweij, Frederik. Institut Curie, France Jerusalem, Israel Visser, Jan-Jaap. London, UK de Keizer, Peter. ErasmusMC, The Netherlands Kloosterman, Wigard. University Medical Center Xia, Bing. The Cancer Institute of NJ, USA Utrecht, Netherlands Knudsen, Karen. Philadelphia University, USA Zaret, Kenneth. Smilow Center for Translational Research, USA Lieberman-Aiden, Erez. Baylor college of Zender, Lars. University Hospital Tübingen, medicine, USA Germany Livingston, David. Dana-Farber Cancer Institute, Zitvogel, Laurence. Gustave Roussy Cancer USA Center, France Lord, Chris. The institute of cancer research, UK Lui, Fan. Utrecht University, The Netherland

Gilliland, Gary. Fred Hutchinson Cancer Research Center, USA Giorgetti, Luca. Friedrich Miescher Institute for Biomedical Research, Switzerland

Huntsman, David. The University of British Columbia, Canada

Landau, Dan. Weill Cornell Medical College, USA

International visitors - 71

72 – International visitors Oncology Graduate School Amsterdam OOA

PhD theses completed

annex 3

Annex 3. PhD theses completed

In 2017, 90 graduate students completed their graduate training and obtained a PhD degree. Their names, thesis titles, supervisors and institutes are listed below.

Name : Aleyd, Esil Title : FcaRI as therapeutic target to reduce IgA-induced neutrophil activation University : Free University Amsterdam (co)Promotors : van Egmond M, Bakema JE Date : 6/1/2017

Name : van Attekum, Martinus Title : Formation of a tumor-supportive microenvironment in chronic lymphocytic leukemia University : University of Amsterdam (co)Promotors : Eldering E, Kater AP Date : 2/24/2017

Name : Bar-Ephraim, Yotam Title : Innate Lymphoid Cells in Human Peripheral Blood and Secondary Lymphoid Organs University : Free University Amsterdam (co)Promotors : Mebius RE, Reijmers M Date : 3/7/2017

Name : Bate Eya, Laurel Title : Crossing borders in targeted therapy University : University of Amsterdam (co)Promotors : Caron HN, Molenaar JJ Date : 9/6/2017

Name : Blomen, Vincent Title : Studying disease-linked phenotypes using haploid genetics University : University Utrecht (co)Promotors : Prof.dr. R.Bernards Date : 14-11-2017

Name : van de Boerdonk, Robert Title : Molecular profiling for risk assessment of pre-invasive endobronchial lesions University : Free University Amsterdam (co)Promotors : Snijders PJF, Smit EF, Heideman DAM Date : 2/8/2017

Name : Bolt, Eva Title : Perspectives on appropriate end-of-life care and hastening death on request University : Free University Amsterdam (co)Promotors : Philipsen-Onwuteaka B,Willems DL Date : 11/2/2017

Name : Borstlap, Wernard Title : Optimisation of surgical care for rectal cancer University : University of Amsterdam (co)Promotors : Bemelman WA, Tanis PJ, Tuynman JB Date : 11/3/2017

PhD theses completed –75 Name : Boshuizen, Rogier Title : Management of malignant pleural effusion University : University of Amsterdam (co)Promotors : Prof.dr. P.Baas Date : 3-2-2017

Name : Braster, Rens Title : Manipulating macrophages: increasing the effectiveness in anti-cancer therapy University : Free University Amsterdam (co)Promotors : van Egmond M, Beelen RHJ, Vidarsson G Date : 2/2/2017

Name : van den Broek, Sandra Title : The impact of BRCA1 and BRCA2 germline mutations on breast cancer outcome in young women University : Free University Amsterdam (co)Promotors : Prof.dr.F.E.van Leeuwen Date : 8-5-2017

Name : Bronsveld, Heleen Title : Unravelling the link between diabetes, insulin treatment and breast cancer University : University of Utrecht (co)Promotors : Prof.dr.T.de Boer Date : 24-8-2017

Name : Bruin, Renee Title : Nanobody based approaches for therapeutic targeting of conserved T cell subsets in cancer University : Free University Amsterdam (co)Promotors : de Gruijl TD, Verheul HMW, van der Vliet JJ Date : 5/16/2017

Name : van Brummelen, Emilie Title : Early clinical development of targeted anticancer agents University : Utrecht University (co)Promotors : Prof.dr.J.Schellens, Prof.dr.J.Beijnen Date : 18-12-201

Name : Brunen, Diede Title : Improving cancer therapy through unraveling drug resistance University : University Utrecht (co)Promotors : Prof.dr. R.Bernards Date : 12-10-2017

Name : Crommentuijn, Thijs Title : Development of vector-based strategies against glioblastoma University : Free University Amsterdam (co)Promotors : Wurdinger T, Noske DP, Tannous BA Date : 11/3/2017

Name : Deijen, Charlotte Title : Innovations in colorectal cancer surgery University : Free University Amsterdam (co)Promotors : Bonjer HJ, Tuynman JB Date : 12/15/2017

Name : Derks, Marloes Title : Radical surgery for early stage cervical cancer University : University of Amsterdam (co)Promotors : Kenter GG, Roovers R, van Lonkhuijzen LRCW, van der Velden JH Date : 12/6/2017

76 - PhD theses completed Name : Dickhoff, Christian Title : The evolving role of surgery in locally advanced NSCLC University : Free University Amsterdam (co)Promotors : Smit EF, Hartemink KJ, Dahele MR Date : 2/8/2017

Name : Dodewaard-de Jong, Joyce Title : Maximizing benefit of radiopharmaceuticals in the systemic treatment of prostate cancer University : Free University Amsterdam (co)Promotors : Verheul HMW, Bloemendal HJ, van den Eertwegh AJM, de Klerk JMH Date : 3/31/2017

Name : Marjolein Droog Title : The effects of breast cancer therapy on estrogen receptor signaling throughout the bo University : University of Leiden (co)Promotors : Prof.dr.J.Neefjes Date : 8-6-2017

Name : van Egmond, Martine Title : Return to work in cancer survivors with job loss University : Free University Amsterdam (co)Promotors : Anema JR, van der Beek AJ, Duijts SFA Date : 1/19/2017

Name : Elshof, Lotte Title : Finding the balance between overtreatment and undertreatment of DCIS University : University of Amsterdam (co)Promotors : Prof.dr.E.Rutgers Date : 3-11-2017

Name : Eskes, Merijn Title : Surface electromyography in personalised modelling of the head and neck University : University Twente/|Enschede (co)Promotors : Prof.dr.H.Balm Date : 13-12-2017

Name : Franke, Niels Title : Molecular mechanisms of bortezomib resistance in acute leukemia University : Free University Amsterdam (co)Promotors : Kaspers GJL, van Vollenhoven RF, Cloos J, Jansen G Date : 9/21/2017

Name : Greuter, Marjolein Title : Colorectal cancer screening: benefit, burden and opportunities University : Free University Amsterdam (co)Promotors : Meijer GA, Brug J, Coupe VMH Date : 1/10/2017

Name : Gurney-Champion, Oliver Title : MRI of pancreatic cancer for radiotherapy University : University of Amsterdam (co)Promotors : Stoker J, Rasch C Date : 3/29/2017

Name : Houlleberghs, Hellen Title : Oligonucleotide-directed mutation screening: a functional test to classify mismatch repair gene variants of uncertain significance University : Free University Amsterdam (co)Promotors : Prof.dr.H.te Riele Date : 30-1-2017

PhD theses completed –77 Name : Ijspeert, Joep Title : Colorectal carcinogenesis and clinical implications University : University of Amsterdam (co)Promotors : Dekker E, Fockens P Date : 1/27/2017

Name : de Jong, Marcus Title : Epidemiology and imaging of retinoblastoma University : Free University Amsterdam (co)Promotors : Castelijns J, Moll AC, de Graaf P Date : 11/24/2017

Name : de Jong, Monique Title : Predicting radioresistance in head and neck cancer University : Free University Amsterdam (co)Promotors : Prof.dr.M.Verheij en M.vd Brekel Date : 5-12-2017

Name : Kadouch, Daniel Title : Confocal microscopy imaging of basal cell carcinoma University : University of Amsterdam (co)Promotors : de Rie M, Wolkerstorfer A, Bekkenk MW Date : 10/18/2017

Name : Kallenberg, Frank Title : Hereditary & familial colorectal cancer: Identification, Characteristics, Surveillance University : University of Amsterdam (co)Promotors : Dekker E, Bossuyt PMM, Aalfs CM Date : 9/8/2017

Name : Kampshoff, Caroline Title : High intensity or low-to-moderate intensity exercise after chemotherapy: for whom and how? University : Free University Amsterdam (co)Promotors : van Mechelen W, Brug J, Buffart LM Date : 6/22/2017

Name : Kersten, Kelly Title : Pulling the strings on anti-cancer immunity. University : University Leiden (co)Promotors : Prof.dr.J.Jonkers Date : 7-2-2017

Name : Kooi, Irsan Title : Applied bioinformatics: Genomics of human and murine retinoblastoma University : Free University Amsterdam (co)Promotors : te Riele H, Moll AC, Dorsman JC, Cloos J Date : 1/24/2017

Name : Koppens, Martijn Title : Guardians of cell identity University : University of Amsterdam (co)Promotors : Prof.dr.M.van Lohuizen Date : 18-5-2017

Name : Kraal, Kathelijne Title : Optimising therapy with 131I-MIBG for neuroblastoma patients and for neuroblastoma patients with intraspinal extension University : University of Amsterdam (co)Promotors : Caron HN, Tytgat GAM, van Noesel CJM Date : 2/10/2017

78 - PhD theses completed Name : van Kranen, Simon Title : Geometric uncertainties and mitigation strategies in radiotherapy of head & neck cancer University : University of Amsterdam (co)Promotors : Rasch C, van Herk M Date : 9/29/2017

Name : Kruizinga, Renske University : University of Amsterdam (co)Promotors : van Laarhoven HWM Date : 12/7/2017

Name : Lam, Joey Title : Breast cancer: therapy and biomarker analysis University : Free University Amsterdam (co)Promotors : Boven E, Honkoop AH, Jimenez CR Date : 2/17/2017

Name : van der Leij, Femke Title : Optimizing treatment of low risk breast cancer patients University : Univesrity of Amsterdam (co)Promotors : Prof.dr.Mark van de Vijver Date : 13-9-2017

Name : Lekkerkerker, Selma Title : Improvement of diagnosis and treatment of pancreatic diseases University : University of Amsterdam (co)Promotors : Fockens P, van Hooft JE, Besselink MGH Date : 7/11/2017

Name : Lens, Eelco Title : Respiratory motion management for radiotherapy of pancreatic cancer patients University : University of Amsterdam (co)Promotors : Rasch C, Bel A, van Tienhoven G Date : 6/2/2017

Name : Leyton Puig, Daniela Title : Shedding light on edoscytosis with optimized super-resolution microscopy University : University of Amsterdam (co)Promotors : Prof.dr.K.Jalink Date : 6-4-2017

Name : Luttmer, Roosmarijn Title : Genital HPV infections in women and men: Improving management strategies University : Free University Amsterdam (co)Promotors : Meijer CJLM, Snijders PJF, Kenter GG, Heideman DAM Date : 12/20/2017

Name : Mari, Luigi Title : Barrett’s esophagus and esophageal adenocarcinoma: from molecular pathogenesis to novel therapeutic targets University : University of Amsterdam (co)Promotors : Krishnadasan B, Fockens P, Calpe S Date : 9/26/2017

Name : Menning, Sanne Title : Multimodal MR imaging in breast cancer - Effects of cancer and cancer treatment on brain and cognition University : Free University Amsterdam (co)Promotors : Prof.dr.Veltman Date : 15-12-2017

PhD theses completed –79 Name : Molenaar, Remco Title : Towards personalised medicine for cancer University : University of Amsterdam (co)Promotors : van Noorden CJF, Vandertop WP, Bleeker WK, Wilmink H Date : 12/22/2017

Name : Nahidiazar, Leila Title : Unraveling intermediate filaments - The super resolution solution University : University of Amsterdam (co)Promotors : Prof.dr.K.Jalink Date : 24-2-2017

Name : Njuguna, Festus Title : Adherence with childhood cancer treatment in Kenya University : Free University Amsterdam (co)Promotors : Kaspers GJL, Mostert SM Date : 4/19/2017

Name : Oei, Arlene Title : Boosting the effectiveness of hyperthermia in cervical carcinoma University : University of Amsterdam (co)Promotors : Medema JP, Stalpers LJA, Franken NAP, Kok HP Date : 3/24/2017

Name : Peulen, Heike Title : Optimization of lung SBRT. Towards Novel Applications University : Free University Amsterdam (co)Promotors : Prof.dr.M.Verheij Date : 8-11-2017

Name : van der Putten, Lisa Title : Diagnosis and salvage surgery of recurrent laryngeal carcinoma after radiotherapy University : Free University Amsterdam (co)Promotors : de Bree R, Leemans CR, Hoekstra OS Date : 6/16/2017

Name : van Ramshorst, Mette Title : Optimizing systemic treatment in HER2-positive early breast cancer University : Utrecht University (co)Promotors : Prof.dr.S.Linn Date : 31-10-2017

Name : Rigter, Lisanne Title : Pathogenesis and prevention of gastrointestinal neoplasia in Hodgkin lymphoma survivo University : Free University Amsterdam Promotors : prof.dr.ir. F.E. van Leeuwen, dr. M.E. van Leerdam, dr. P. Snaebjornsson Date : 13-12-2017

Name : Roemer, Marit Title : Targetable genetic signatures of immune evasion in lymphoma University : Free University Amsterdam (co)Promotors : de Jong D, Shipp MA, Ylstra B, Chapuy B Date : 11/20/2017

Name : Rood, Janneke Title : Perceived need for information and treatment decision-making in patients with hematological malignancies: nog "one size fits all" University : Free University Amsterdam (co)Promotors : Verdonck-de Leeuw IM, Zweegman S, Stam F, van Zuuren EJ Date : 9/11/2017

80 - PhD theses completed Name : de Rooij, Martin Title : Targeting the BCR signalosome in B cell malignancies University : University of Amsterdam (co)Promotors : Pals G, Spaargaren M Date : 12/20/2017

Name : Rozendaal, Roel Title : Large-scale in vivo EPID dosimetry University : University of Amsterdam (co)Promotors : Prof.dr.M.van Herk Date : 7-11-2017

Name : Samuels, Sanne Title : The role of the immune system in cervical cancer University : Free University Amsterdam (co)Promotors : Kenter GG, Jordanova ES Date : 9/7/2017

Name : Scheinin, Ilari Title : Bioinformatic solutions for chromosomal copy number analysis in cancer University : Free University Amsterdam (co)Promotors : Ylstra B, van de Wiel MA Date : 12/13/2017

Name : Schepers, Saskia Title : Changing pediatric cancer care: development and implementation of electronic patient and parent reported outcomes (co)Promotors : Grootenhuis MA, Caron HN Date : 1/11/2017

Name : Scholvinck, Dirk Title : Advances in approach and therapy for early esophageal neoplasia University : University of Amsterdam (co)Promotors : Bergman JJGHM Date : 9/27/2017

Name : Schouten, Charlotte Title : Diffusion-weighted MRI and 18F-FDG-PET-CT in head and neck cancer: prediction and response evaluation University : Free University Amsterdam (co)Promotors : de Bree R, Castelijns J, Hoekstra OS, Leemans CR Date : 11/6/2017

Name : Schouten, Philip Title : Identification and treatment of patients with BRCA1 or BRCA2-defective breast and ovarian cancer University : Utrecht University (co)Promotors : Prof.dr.S.Linn Date : 17-1-2017

Name : Schuitema, Ilse Title : Long-term neurocognitive effects of treatment for pediatric lymphoid malignancies University : Free University Amsterdam (co)Promotors : Kaspers GJL, de Sonneville LMJ, van den Bos C Date : 4/19/2017

Name : Sewing, Lot Title : Disease models and translational research in diffuse intrinsic pontine glioma University : Free University Amsterdam (co)Promotors : Kaspers GJL, Vandertop WP, Hulleman E Date : 11/28/2017

PhD theses completed –81 Name : Sie, Daoud Title : Breaking the Cancer Genome Code for Patient Care University : Free University Amsterdam (co)Promotors : Ylstra B, Albertson DG, Sistermans E, Heideman DAM Date : 1/31/2017

Name : Sluis, Tim Title : New insights in steroid hormone metabolism in prostate cancer University : Free University Amsterdam (co)Promotors : Meuleman EJH, van Moorselaar RJA, Vis A, Heijboer A Date : 5/18/2017

Name : van der Steen, Nele Title : The labyrinth of cMET and EGFR signaling in non-small cell lung cancer University : Free University Amsterdam (co)Promotors : Peters GJ, Giovannetti E Date : 09/30/2017

Name : Stiekema, Anna Title : HE4: Clinical applications in gynaecological cancer University : University of Amsterdam (co)Promotors : Kenter GG, Lok CA, Korse CM Date : 2/9/2017

Name : Stoker, Sharon Title : Persistent and recurrent nasopharyngeal carcinoma: Focused on Indonesia University : Free University Amsterdam (co)Promotors : Tan IB, Leemans CR, Middeldorp JM, de Boer JP Date : 5/31/2017

Name : Swager, Anne-Fe Title : Volumetric laser endomicroscopy for the detection of early Barrett’s neoplasia University : University of Amsterdam (co)Promotors : Bergman JJGHM Date : 6/2/2017

Name : Teixera, Suzana Title : Breast cancer tailored staging using molecular imaging University : University of Amsterdam (co)Promotors : Prof.dr.E.Rutgers Date : 14-9-2017

Name : van Tilborg, Aukje Title : Thermal ablation of liver tumors: validation and implementation in clinical practice University : Free University Amsterdam (co)Promotors : van Kuijk C, Meijerink MR, van den Tol MP Date : 5/18/2017

Name : Uijterwaal, Margot Title : Novel biomarkers for cervical screening and surveillance of women treated for cervical precancer University : Free University Amsterdam (co)Promotors : Meijer CJLM, Helmerhorst TJM, Steenbergen RDM, Berkhof J Date : 1/9/2017

Name : Veldhuijzen van Zanten, Sophie Title : Diffuse intrinsic pontine glioma: a multi-facetted and global view University : Free University Amsterdam (co)Promotors : Kaspers GJL, Vandertop WP, van Vuurden DG Date : 11/28/2017

82 - PhD theses completed Name : Visser, Nicole Title : How oncologists’ communication impacts patients’ information recall and emotional stress University : University of Amsterdam (co)Promotors : Smets EMA, de Haes JCJM, Tollenaar RA Date : 12/8/2017

Name : Vlaming, Hanneke Title : Connecting the Dots. Delineating the Regulation of H3K79 Methylation by Dot1. University : University of Amsterdam (co)Promotors : Prof.dr.M.van Lohuizen Date : 16-3-2017

Name : van der Vlugt, Manon Title : Population-based colorectal cancer screening by fecal immunochemical testing over multiple rounds University : University of Amsterdam (co)Promotors : Dekker E, Bossuyt PMM Date : 11/24/2017

Name : Vriend, Lianne Title : Homologous recombination in genome maintenance and cancer treatment University : University of Amsterdam (co)Promotors : van Noorden CJF, Krawczyk P Date : 3/22/2017

Name : van Waart, Hanna Title : Physical exercise during adjuvant chemotherapy University : University of Amsterdam (co)Promotors : Prof.dr.N.Aaronson Date : 30-11-2017

Name : Weeber, Fleur Title : Predicting treatment outcome by DNA and organoids University : University Utrecht (co)Promotors : Prof.dr. E.Voest Date : 21-12-2017

Name : de Weger, Vincent Title : Clinical pharmacology of novel anticancer agents - focus on oral formulations University : Utrecht University (co)Promotors : Prof.dr. J.Schellens and Prof.dr.J.H.Beijnen Date : 20-12-2017

Name : Weijer, Ruud Title : Enhancing photodynamic therapy of refractory solid cancers University : University of Amsterdam (co)Promotors : van Gulik TM, Heger M Date : 2/24/2017

Name : Wijdeven, Roel Title : Novel regulators of endosome biology, MHCII antigen presentation and chemosensitivit University : Leiden University (co)Promotors : Prof.dr.J.Neefjes Date : 29-11-2017

Name : Wildt, Berend Title : Development of PET tracers for in vivo imaging of active tissue transglutaminase University : Free University Amsterdam (co)Promotors : Windhorst AD, Lammertsma AA Date : 6/26/2017

Name : Wind, Anke Title : Benchmarking comprehensive cancer care University : University Twente (co)Promotors : Prof.dr.W.van Harten

PhD theses completed –83 Date : 13-4-201

Name : Zeijlemaker, Wendelien Title : Leukemic stem cells and measurable residual disease in AML: An emerging new outcome parameter University : Free University Amsterdam (co)Promotors : Ossenkoppele GJ, Schuurhuis GJ Date : 11/21/2017

84 - PhD theses completed Oncology Graduate School Amsterdam OOA

Scientific publications

annex 4

Annex 4. Scientific publications

1. Cloos J, Roeten MSF, Franke NE, van Meerloo J, Zweegman S, Kaspers GJL et al.(Immuno)proteasomes as therapeutic target in acute leukemia. Cancer and Metastasis Reviews. 2017 Dec;1-17 (VUmc) 2. van Zeijl MCT, van den Eertwegh AJ, Haanen JB, Wouters MWJM.(Neo)adjuvant systemic therapy for melanoma. European Journal of Surgical Oncology. 2017 Mar 1;43(3):534-543(NKI-AvL, VUmc) 3. Miquel-Cases A, Schouten PC, Steuten LM, Retel VP, Linn SC, van Harten WH.(Very) Early technology assessment and translation of predictive biomarkers in breast cancer. Cancer Treat Rev 2017; 52:117-27 (NKI-AvL) 4. de Jong EEC, van Elmpt W, Leijenaar RTH, Hoekstra OS, Groen HJM, Smit EF et al.[18F]FDG PET/CT- based response assessment of stage IV non-small cell lung cancer treated with paclitaxel-carboplatin- bevacizumab with or without nitroglycerin patches. European Journal of Nuclear Medicine and Molecular Imaging. 2017 Jan;44(1):8-16(NKI-AvL, VUmc) 5. Goveart JA, van Dijk WA, Wouters MW.[Better care and lower costs through registries; a first step to reimbursement based on outcome]. Ned Tijdschr Geneeskd 2017; 161:D945 (NKI-AvL) 6. van Leerdam ME.[Early discharge possible in acute upper gastrointestinal bleeding; new study results require adaptation of Dutch guideline]. Ned Tijdschr Geneeskd 2017; 161:D1669 (NKI-AvL) 7. Dirven R, Lieben G, Bouwman S, Wolterink R, van den Brekel MWM, Lohuis PJFM.[Facial prosthetics: grounds and techniques]. Ned Tijdschr Tandheelkd 2017; 124:413-7 (NKI-AvL) 8. de Neree Tot Babberich MPM, van der Willik EM, van Groningen JT, Ledeboer M, Wiggers T, Wouters MWJM.[Surgery for Colorectal Cancer since the Introduction of the Netherlands National Screening Programmeinvestigations into Changes in Number of Resections and Waiting Times for Surgery]. Ned Tijdschr Geneeskd 2017; 161:D997 (NKI-AvL) 9. Madu MF, van de Wiel B, van Akkooi ACJ.1 mm) Sentinel Lymph Node Metastases Comment: Detailed Pathologic Examination of Completion Node Dissection Specimens and Outcome for Melanoma Patients with Minimal (< 0. Ann Surg Oncol 2017; 24(Suppl 3):658-9[Comment] (NKI-AvL) 10. Samim M, Prevoo W, de Wit-van der Veen BJ, Kuhlmann KF, Ruers T, van Hillegersberg R, van den Bosch MA, Verkooijen HM, Lam MG, Stokkel MPM.18F-FDG PET as novel imaging biomarker for disease progression after ablation therapy in colorectal liver metastases. Eur J Nucl Med Mol Imaging 2017; 44:1165-75 (NKI-AvL) 11. Dupuis LL, Sung L, Molassiotis A, Orsey AD, Tissing W, van de Wetering MD.2016 updated MASCC/ESMO consensus recommendations: Prevention of acute chemotherapy-induced nausea and vomiting in children.Supportive care in cancer.2017;25(1):323-331 (AMC) 12. Pan H, Gray R, Braybrooke J, Davies C, Taylor C, McGale P, Peto R, Pritchard KI, Bergh J, Dowsett M, Hayes DF, (Collaborators: 632), Rutgers E, Van Tinteren H.20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years. N Engl J Med 2017; 377:1836-46 (AMC,NKI-AvL) 13. van Leeuwen CM, Crezee J, Oei AL, Franken NAP, Stalpers LJA, Bel A, Kok HP.3D radiobiological evaluation of combined radiotherapy and hyperthermia treatments.International journal of hyperthermia.2017;33(2):160-169 (AMC) 14. Verly IRN, van Kuilenburg ABP, Abeling NGGM, Goorden SMI, Fiocco M, Vaz FM, van Noesel MM, Zwaan CM, Kaspers GJL, Merks JHM, Caron HN, Tytgat GAM.3-Methoxytyramine: An independent prognostic biomarker that associates with high-risk disease and poor clinical outcome in neuroblastoma patients.European journal of cancer (Oxford, England.2017;90():102-110 (AMC) 15. Lorje T, Barlo N, Reichert CLA, de Kanter W, Sluman MA.A 46-year-old man with recurrent embolic events. Neth Heart J 2017; 25:695-6 [Heart beat] (NKI-AvL) 16. Keikes L, Klümpen H, van Laarhoven HWM.A 52-year-old oncology patient with acute severe abdominal pain.Netherlands journal of medicine.2017;75(8):359-360 (AMC) 17. Torres-Xirau I, Olaciregui-Ruiz I, Rozendaal RA, Gonzalez P, Mijnheer BJ, Sonke JJ, van der Heide UA, Mans A.A back-projection algorithm in the presence of an extra attenuating medium: towards EPID dosimetry for the MR-Linac. Phys Med Biol 2017; 62:6322-40 (NKI-AvL) 18. Duijts SFA, Bleiker EMA, Paalman CH, van der Beek AJ.A behavioural approach in the development of work-related interventions for cancer survivors: an exploratory review. European Journal of Cancer Care. 2017 Sep 1;26(5):e12545(NKI-AvL, VUmc) 19. Delahaye LJMJ, Drukker CA, Dreezen C, Witteveen A, Chan B, Snel M, Beumer IJ, Bernards R, Audeh MW, van't Veer LJ, Glas AM.A breast cancer gene signature for indolent disease. Breast Cancer Res Treat 2017; 164:461-6 (NKI-AvL)

Scientific publications - 87 20. Amado-Azevedo J, Reinhard NR, van Bezu J, Menezes RX, Van Beusechem VW, Van Nieuw Amerongen GP et al.A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity. Scientific Reports. 2017 Dec 1;7(1):10132 (VUmc) 21. Berrington de Gonzalez A, Vikram B, Buchsbaum JC, de Vathaire F, Dörr W, Hass-Kogan D, Langendijk JA, Mahajan A, Newhauser W, Ottolenghi A, Ronckers CM, Schulte R, Walsh L, Yock TI, Kleinerman RA.A Clarion Call for Large-Scale Collaborative Studies of Pediatric Proton Therapy.International journal of radiation oncology, biology, physics.2017;98(5):980-981 (AMC) 22. Sabrkhany S, Kuijpers MJE, van Kuijk SMJ, Sanders L, Pineda S, Olde Damink SWM et al.A combination of platelet features allows detection of early-stage cancer. European Journal of Cancer. 2017 Jul 1;80:5-13 (VUmc) 23. Kok HP, Crezee J.A comparison of the heating characteristics of capacitive and radiative superficial hyperthermia.International journal of hyperthermia.2017;33(4):378-386 (AMC) 24. In 't Veld SGJG, Duong KN, Snel M, Witteveen A, Beumer IJ, Delahaye LJMJ, Wehkamp D, Bernards R, Glas AM, Tian S.A Computational Workflow Translates a 58-Gene Signature to a Formalin-Fixed, Paraffin- Embedded Sample-Based Companion Diagnostic for Personalized Treatment of the BRAF-Mutation-Like Subtype of Colorectal Cancers. High Throughput 2017; 6:16 (11 pp) (NKI-AvL) 25. Bakker RM, Pieterse QD, van Lonkhuijzen LRCW, Trimbos BJBMZ, Creutzberg CL, Kenter GG et al.A Controlled Study on Vaginal Blood Flow During Sexual Arousal Among Early-Stage Cervical Cancer Survivors Treated With Conventional Radical or Nerve-Sparing Surgery With or Without Radiotherapy. International Journal of Gynecological Cancer. 2017 Jun;27(5):1051-1057(AMC, VUmc) 26. MacLennan S, Williamson PR, Bekema H, Campbell M, Ramsay C, N'Dow J, MacLennan S, Vale L, Dahm P, Mottet N, Lam T, Abel P, Ahmed HU, Akehurst G, Almquist R, Beck K, Budd D, Canfield S, Catto J, Cornford P, Cross W, Ewen A, Grant J, Heer R, Hurst D, Jones R, Kockelbergh R, Mackie A, MacDonald G, McNeill A, Mason M, McClinton S, McLaren D, Mostafid H, Pearce I, Pennet L, Royle J, Schreuder H, Stewart GD, van der Poel H, Wardlaw K, Wiegel T.A core outcome set for localised prostate cancer effectiveness trials. BJU Int 2017; 120:E64-E79 (NKI-AvL) 27. Kloos RQH, Uyl-de Groot CA, van Litsenburg RRL, Kaspers GJL, Pieters R, van der Sluis IM.A cost analysis of individualized asparaginase treatment in pediatric acute lymphoblastic leukemia. Pediatric Blood and Cancer. 2017 Dec 1;64(12):e26651 (VUmc) 28. de Weger VA, Stuurman FE, Hendrikx JJMA, Moes JJ, Sawicki E, Huitema ADR, Nuijen B, Thijssen B, Rosing H, Keessen M, Mergui-Roelvink M, Beijnen JH, Schellens JHM, Marchetti S.A dose-escalation study of bi-daily once weekly oral docetaxel either as ModraDoc001 or ModraDoc006 combined with ritonavir. Eur J Cancer 2017; 86:217-25 (NKI-AvL) 29. van Stam G, Kok HP, Hulshof MCCM, Kolff WW, van Tienhoven G, Sijbrands J, Bakker A, Zum Vörde Sive Vörding PJ, Oldenborg S, de Greef M, Rasch CRN, Crezee J.A flexible 70 MHz phase-controlled double waveguide system for hyperthermia treatment of superficial tumours with deep infiltration.International journal of hyperthermia.2017;33(7):796-809 (AMC) 30. Wang L, Sustic T, Leite de Oliveira R, Lieftink C, Halonen P, van de Ven M, Beijersbergen RL, van den Heuvel MM, Bernards R, van der Heijden MS.A Functional Genetic Screen Identifies the Phosphoinositide 3-kinase Pathway as a Determinant of Resistance to Fibroblast Growth Factor Receptor Inhibitors in FGFR Mutant Urothelial Cell Carcinoma. Eur Urol 2017; 71:858-62 (NKI-AvL) 31. Siebring-van Olst E, Blijlevens M, de Menezes RX, van der Meulen-Muileman IH, Smit EF, van Beusechem VW.A genome-wide siRNA screen for regulators of tumor suppressor p53 activity in human non-small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment. Molecular oncology. 2017 May;11(5):534-551(NKI-AvL, VUmc) 32. van Beijnum JR, Nowak-Sliwinska P, van Berkel M, Wong TJ, Griffioen AW.A genomic screen for angiosuppressor genes in the tumor endothelium identifies a multifaceted angiostatic role for bromodomain containing 7 (BRD7). Angiogenesis. 2017 Nov 1;20(4):641-654 (VUmc) 33. Krebber AMH, van Uden-Kraan CF, Melissant HC, Cuijpers P, van Straten A, Becker-Commissaris A et al.A guided self-help intervention targeting psychological distress among head and neck cancer and lung cancer patients: motivation to start, experiences and perceived outcomes. Supportive Care in Cancer. 2017 Jan 1;25(1):127-135 (VUmc) 34. Coppola S, Carnevale I, Danen EHJ, Peters GJ, Schmidt T, Assaraf YG et al.A mechanopharmacology approach to overcome chemoresistance in pancreatic cancer. Drug Resistance Updates. 2017 Mar 1;31:43-51 (VUmc) 35. Petrulli JR, Hansen SB, Abourbeh G, Yaqub M, Bahce I, Holden D et al.A multi species evaluation of the radiation dosimetry of [11C]erlotinib, the radiolabeled analog of a clinically utilized tyrosine kinase inhibitor. Nuclear Medicine and Biology. 2017 Apr 1;47:56-61 (VUmc) 36. Joint Head and Neck Radiotherapy-MRI Development Cooperative, (Collaborators 32), Ger RB, et al, van der Heide UA.A Multi-Institutional Comparison of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameter Calculations. Sci Rep 2017; 7:11185 (12 pp) (NKI-AvL) 37. Buijs N, Oosterink JE, Jessup M, Schierbeek H, Stolz DB, Houdijk AP et al.A new key player in VEGF- dependent angiogenesis in human hepatocellular carcinoma: dimethylarginine dimethylaminohydrolase 1. Angiogenesis. 2017 Nov 1;20(4):557-565 (VUmc) 38. Koppens MA, Tanger E, Nacerddine K, Westerman B, Song JY, van Lohuizen M.A new transgenic mouse model for conditional overexpression of the Polycomb Group protein EZH2. Transgenic Res 2017; 26:187- 96 (NKI-AvL)

88 - Scientific publications 39. Haghiralsadat F, Amoabediny G, Sheikhha MH, Forouzanfar T, Arough JM, Helder MN et al.A novel approach on drug delivery: Investigation of a new nano-formulation of liposomal doxorubicin and biological evaluation of entrapped doxorubicin on various osteosarcoma cell lines. Cell Journal. 2017 Mar 1;19:55-64 (VUmc) 40. Sijbrandi NJ, Merkul E, Muns JA, Waalboer DCJ, Adamzek K, Bolijn M et al.A novel platinum(II)-based bifunctional ADC linker benchmarked using 89Zr-Desferal and auristatin F-conjugated trastuzumab. Cancer Research. 2017 Jan 15;77(2):257-267 (VUmc) 41. Hellingman D, Teixeira SC, Donswijk ML, Rijkhorst EJ, Moliner L, Alamo J, Loo CE, Valdes Olmos RA, Stokkel MPM.A novel semi-robotized device for high-precision 18F-FDG-guided breast cancer biopsy. Rev Esp Med Nucl Imagen Mol 2017; 36:158-65 (NKI-AvL) 42. Van Dodewaard-De Jong JM, Bouman-Wammes EW, Bloemendal HJ, Verheul HMW, De Klerk JMH, Van Den Eertwegh AJM.A phase 1 trial of cabazitaxel combined with 188Re-hydroxyethylidene diphosphonate in patients with metastatic castration-resistant prostate cancer who progressed on or after a docetaxel- containing treatment the ReCab trial. Clinical Nuclear Medicine. 2017;42(6):415-420 (VUmc) 43. van Geel RM, Tabernero J, Elez E, Bendell JC, Spreafico A, Schuler M, Yoshino T, Delord JP, Yamada Y, Lolkema M, Faris JE, Eskens FA, Sharma S, Yaeger R, Lenz HJ, Wainberg ZA, Avsar E, Chatterjee A, Jaeger S, Tan E, Maharry K, Demuth T, Schellens JHM.A Phase 1b Dose-Escalation Study of Encorafenib (LGX818) and Cetuximab With or Without Alpelisib in Metastatic BRAF-Mutant Colorectal Cancer. Cancer Discov 2017; 7:610-9 (NKI-AvL) 44. Leong S, Moss RA, Bowles DW, Ware JA, Zhou J, Spoerke JM, Lackner MR, Shankar G, Schutzman JL, van der Noll R, Voest EE, Schellens JHM.A Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of Pictilisib in Combination with Erlotinib in Patients with Advanced Solid Tumors. Oncologist 2017; 22:1491-9 (NKI-AvL) 45. de Jonge M, de Weger VA, Dickson MA, Langenberg M, Le Cesne A, Wagner AJ, Hsu K, Zheng W, Mace S, Tuffal G, Thomas K, Schellens JHM.A phase I study of SAR405838, a novel human double minute 2 (HDM2) antagonist, in patients with solid tumours. Eur J Cancer 2017; 76:144-51 (NKI-AvL) 46. Franssen LE, Roeven MWH, Hobo W, Doorn R, Oostvogels R, Falkenburg JHF et al.A phase I/II minor histocompatibility antigen-loaded dendritic cell vaccination trial to safely improve the efficacy of donor lymphocyte infusions in myeloma. Bone Marrow Transplantation. 2017 Oct 1;52(10):1378-1383(AMC, VUmc) 47. Veldhuijzen van Zanten SEM, El-Khouly FE, Jansen MHA, Bakker DP, Sanchez Aliaga E, Haasbeek CJA et al.A phase I/II study of gemcitabine during radiotherapy in children with newly diagnosed diffuse intrinsic pontine glioma. Journal of Neuro-Oncology. 2017 Nov 1;135(2):307-315(AMC, VUmc) 48. Molenaar RJ, van de Venne T, Weterman MJ, Mathot RAA, Klumpen H-J, Richel DJ, Wilmink JW.A phase Ib study of everolimus combined with metformin for patients with advanced cancer.Investigational new drugs.2017 (AMC) 49. Laquente B, Lopez-Martin J, Richards D, Illerhaus G, Chang DZ, Kim G, Stella P, Richel DJ, Szcylik C, Cascinu S, Frassineti GL, Ciuleanu T, Hurt K, Hynes S, Lin J, Lin AB, Von Hoff D, Calvo E.A phase II study to evaluate LY2603618 in combination with gemcitabine in pancreatic cancer patients.BMC cancer.2017;17(1):137 (AMC) 50. Szeto YZ, Witte MG, van Herk M, Sonke JJ.A population based statistical model for daily geometric variations in the thorax. Radiother Oncol 2017; 123:99-105 (NKI-AvL) 51. Thong MSY, Kicinski M, Coens C, Giusti F, van de Poll-Franse L, Bogaerts J, Liu L.A population-based approach to compare patient-reported outcomes of long-term Hodgkin's lymphosma survivors according to trial participation: a joint study from the Patient-Reported Outcomes Following Initial Treatment and Long-term Evaluation of Survivorship registry and European Organisation for Research and Treatment of Cancer. Eur J Cancer Prev 2017; 26:S223-S228 (NKI-AvL) 52. van Praag VM, Rueten-Budde AJ, Jeys LM, Laitinen M, Pollock R, Aston W, van de Hage JA, Dijkstra PDS, Ferguson PC, Griffin AM, Willeumier JJ, Wunder JS, van de Sande MAJ, Fiocco M.A prediction model for treatment decisions in high-grade extremity soft-tissue sarcomas: Personalised sarcoma care (PERSARC). Eur J Cancer 2017; 83:313-23 (NKI-AvL) 53. Gouw ZAR, Jasperse B, Sonke JJ, Heemsbergen WD, Navran A, Hamming-Vrieze O, Paul de Boer J, van den Brekel MWM, Al Mamgani A.A predictive model for residual disease after (chemo) radiotherapy in oropharyngeal carcinoma: Combined radiological and clinical evaluation of tumor response. Clin Transl Radiat Oncol 2017; 6:1-6 (NKI-AvL) 54. Seesing MFJ, Gisbertz SS, Goense L, van Hillegersberg R, Kroon HM, Lagarde SM, Ruurda JP, Slaman AE, van Berge Henegouwen MI, Wijnhoven BPL.A Propensity Score Matched Analysis of Open Versus Minimally Invasive Transthoracic Esophagectomy in the Netherlands.Annals of surgery.2017;266(5):839-846 (AMC) 55. Lange M, Hage JJ, van Beurden M.A Prospective Assessment of Surgical Risk Factors in 114 Gluteal Fold Flap Reconstructions After Oncological Vulvoperineal Resection to Establish Clinically Relevant Selection Criteria. Ann Plast Surg 2017; 79:53-9 (NKI-AvL) 56. 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Muller BG, Swaan A, de Bruin DM, van den Bos W, Schreurs AW, Faber DJ, Zwartkruis ECH, Rozendaal L, Vis AN, Nieuwenhuijzen JA, van Moorselaar RJA, van Leeuwen AGJM, Delarosette JJMCH.Customized Tool for the Validation of Optical Coherence Tomography in Differentiation of Prostate Cancer.Technology in cancer research & treatment.2017;16(1):57-65 (AMC) 336. Correa RM, Vladimirsky S, Heideman DAM, Coringrato M, Abeldaño A, Olivares L et al.Cutaneous human papillomavirus genotypes in different kinds of skin lesions in Argentina. Journal of Medical Virology. 2017 Feb;89(2):352-357 (VUmc) 337. Vos JM, Tsakmaklis N, Patterson CJ, Meid K, Castillo JJ, Brodsky P, Ganz T, Pals ST, Kersten MJ, Xu L, Yang G, Treon SP, Hunter ZR.CXCL13 levels are elevated in patients with Waldenstrom macroglobulinemia, and are predictive of major response to ibrutinib.Haematologica.2017;102(11):E452-E455 (AMC) 338. 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106 - Scientific publications tumors.INTERNATIONAL JOURNAL OF MICROWAVE AND WIRELESS TECHNOLOGIES.2017;9(6):1317-1324 (AMC) 367. Yu H, van Erp N, Bins S, Mathijssen RH, Schellens JHM, Beijnen JH, Steeghs N, Huitema ADR.Development of a Pharmacokinetic Model to Describe the Complex Pharmacokinetics of Pazopanib in Cancer Patients. Clin Pharmacokinet 2017; 56:293-303 (NKI-AvL) 368. Oort Q, Dirven L, Meijer W, Sikkes SAM, Uitdehaag BMJ, Reijneveld JC et al.Development of a questionnaire measuring instrumental activities of daily living (IADL) in patients with brain tumors: a pilot study. Journal of Neuro-Oncology. 2017 Mar 1;132(1):145-153 (VUmc) 369. Khan S, Oosterhuis K, Wunderlich K, Bunnik EM, Bhaggoe M, Boedhoe S et al.Development of a replication-deficient adenoviral vector-based vaccine candidate for the interception of HPV16- and HPV18-induced infections and disease. International Journal of Cancer. 2017 Jul 15;141(2):393-404 (VUmc) 370. Zaman A-CGNM, Tytgat KMAJ, Van Hezel S, Klinkenbijl JHG, de Boer AGEM, Frings-Dresen MHW.Development of a tailored work-related support intervention for gastrointestinal cancer patients.European journal of cancer care.2017 (AMC) 371. Dirven L, Taphoorn MJB, Groenvold M, Habets EJJ, Aaronson NK, Conroy T et al.Development of an item bank for computerized adaptive testing of self-reported cognitive difficulty in cancer patients. Neuro- Oncology Practice. 2017 Sep;4(3):189-196 (VUmc) 372. Rovithi M, Avan A, Funel N, Leon LG, Gomez VE, Wurdinger T et al.Development of bioluminescent chick chorioallantoic membrane (CAM) models for primary pancreatic cancer cells: A platform for drug testing. Scientific Reports. 2017 Mar 17;7:44686 (VUmc) 373. van der Wildt B, Wilhelmus MMM, Kooijman EJM, Jongenelen CAM, Schuit RC, Büchold C et al.Development of fluorine-18 labeled peptidic PET tracers for imaging active tissue transglutaminase. Nuclear Medicine and Biology. 2017 Jan 1;44:90-104 (VUmc) 374. Brouwer NJ, Haanen JBAG, Jager MJ.Development of Ocular Rosacea following Combined Ipilimumab and Nivolumab Treatment for Metastatic Malignant Skin Melanoma. Ocul Oncol Pathol 2017; 3:188-92 (NKI-AvL) 375. Boretto M, Cox B, Noben M, Hendriks N, Fassbender A, Roose H, Amant F, Timmerman D, Tomassetti C, Vanhie A, Meuleman C, Ferrante M, Vankelecom H.Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability. Development 2017; 144:1775-86 (NKI-AvL) 376. van Baal JOAM, van Noorden CJF, Nieuwland R, van de Vijver KK, Sturk A, van Driel WJ, Kenter GG, Lok CAR.Development of Peritoneal Carcinomatosis in Epithelial Ovarian Cancer: A Review.journal of histochemistry and cytochemistry.2017;():22155417742897 (AMC) 377. 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Scientific publications - 107 subtyping basal cell carcinoma.Journal of the European Academy of Dermatology and Venereology.2017;31(10):1641-1648(AMC, VUmc) 385. Verburg N, Hoefnagels FWA, Barkhof F, Boellaard R, Goldman S, Guo J et al.Diagnostic Accuracy of Neuroimaging to Delineate Diffuse Gliomas within the Brain: A Meta-Analysis. American Journal of Neuroradiology. 2017 Oct;38(10):1884-1891(AMC, VUmc) 386. Baard J, de Bruin DM, Zondervan PJ, Kamphuis GM, Delarosette JJMCH, Laguna Pes MP.Diagnostic dilemmas in patients with upper tract urothelial carcinoma.Nature reviews. Urology.2017;14(3):181-191 (AMC) 387. Ponds FAM, van Raath MI, Mohamed SMM, Smout AJPM, Bredenoord AJ.Diagnostic features of malignancy-associated pseudoachalasia.Alimentary pharmacology & therapeutics.2017;45(11):1449-1458 (AMC) 388. 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Scientific publications - 113 510. Crombag LMM, Szlubowski A, Stigt JA, Schuurbiers O, Korevaar DA, Bonta PI, Annema JT.EUS-B-FNA vs conventional EUS-FNA for left adrenal gland analysis in lung cancer patients.Lung cancer (Amsterdam, Netherlands).2017;108():38-44 (AMC) 511. Keikes L, Koopman M, Tanis PJ, Lemmens VEPP, Punt CJA, van Oijen MGH.Evaluating the scientific basis of quality indicators in colorectal cancer care: A systematic review.European journal of cancer (Oxford, England.2017;86():166-177 (AMC) 512. Savolainen H, Windhorst AD, Elsinga PH, Cantore M, Colabufo NA, Willemsen ATM et al.Evaluation of [18F]MC225 as a PET radiotracer for measuring P-glycoprotein function at the blood-brain barrier in rats: Kinetics, metabolism, and selectivity. Journal of Cerebral Blood Flow and Metabolism. 2017;37(4):1286- 1298 (VUmc) 513. Mynarek M, Pizer B, Dufour C, Van Vuurden D, Garami M, Massimino M et al.Evaluation of age-dependent treatment strategies for children and young adults with pineoblastoma: Analysis of pooled European Society for Paediatric Oncology (SIOP-E) and US Head Start data. Neuro-Oncology. 2017 Apr 1;19(4):576- 585 (VUmc) 514. Kallenberg FGJ, Aalfs CM, The FO, Wientjes CA, Depla AC, Mundt MW, Bossuyt PMM, Dekker E.Evaluation of an online family history tool for identifying hereditary and familial colorectal cancer.Familial cancer.2017 (AMC) 515. Nogova L, Sequist LV, Perez Garcia JM, Andre F, Delord JP, Hidalgo M, Schellens JHM, Cassier PA, Camidge DR, Schuler M, Vaishampayan U, Burris H, Tian GG, Campone M, Wainberg ZA, Lim WT, LoRusso P, Shapiro GI, Parker K, Chen X, Choudhury S, Ringeisen F, Graus-Porta D, Porter D, Isaacs R, Buettner R, Wolf J.Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study. J Clin Oncol 2017; 35:157-65 (NKI-AvL) 516. Walker LC, Marquart L, Pearson JF, Wiggins GAR, O'Mara TA, Parsons MT, Barrowdale D, McGuffog L, Dennis J, Benitez J, Slavin TP, Radice P, Frost D, Godwin AK, Meindl A, Schmutzler RK, Isaacs C, Peshkin BN, Caldes T, Hogervorst FBL, Lazaro C, Jakubowska A, Montagna M, Chen X, Offit K, Hulick PJ, Andrulis IL, Lindblom A, Nussbaum RL, Nathanson KL, Chenevix-Trench G, Antoniou AC, Couch FJ, Spurdle AB.Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers. Eur J Hum Genet 2017; 25:432-8 (NKI-AvL) 517. Tshomo U, Franceschi S, Tshokey T, Tobgay T, Baussano I, Tenet V et al.Evaluation of cytology versus human papillomavirus-based cervical cancer screening algorithms in Bhutan. Oncotarget. 2017 Sep 22;8(42):72438-72446 (VUmc) 518. Keikes L, van Oijen MGH, Lemmens VEPP, Koopman M, Punt CJA.Evaluation of Guideline Adherence in Colorectal Cancer Treatment in The Netherlands: A Survey Among Medical Oncologists by the Dutch Colorectal Cancer Group.Clinical colorectal cancer.2017 (AMC) 519. Ebisch RMF, Van Der Horst J, Hermsen M, Lucia Rijstenberg L, Vedder JE, Bulten J et al.Evaluation of p16/Ki-67 dual-stained cytology as triage test for high-risk human papillomavirus-positive women. Modern Pathology. 2017 Jul 1;30(7):1021-1031 (VUmc) 520. Polman NJ, Oštrbenk A, Xu L, Snijders PJF, Meijer CJLM, Poljak M et al.Evaluation of the clinical performance of the HPV-risk assay using the VALGENT-3 panel. Journal of Clinical Microbiology. 2017 Dec 1;55(12):3544-3551 (VUmc) 521. Sobral-Leite M, Lips EH, Vieira-Monteiro HA, Giacomin LC, Freitas-Alves DR, Cornelissen S, Mulder L, Wesseling J, Schmidt MK, Vianna-Jorge R.Evaluation of the EGFR polymorphism R497K in two cohorts of neoadjuvantly treated breast cancer patients. PLoS One 2017; 12:e0189750 (18 pp) (NKI-AvL) 522. Kieffer JM, Postma TJ, van de Poll-Franse L, Mols F, Heimans JJ, Cavaletti G et al.Evaluation of the psychometric properties of the EORTC chemotherapy-induced peripheral neuropathy questionnaire (QLQ-CIPN20). Quality of Life Research. 2017 Nov 1;26(11):2999-3010(NKI-AvL, VUmc) 523. Weller M, van den Bent M, Tonn JC, Stupp R, Preusser M, Cohen-Jonathan-Moyal E et al.Evidence-based management of adult patients with diffuse glioma – Authors' reply. The Lancet Oncology. 2017 Aug 1;18(8):e430-e431 (VUmc) 524. Spronk I, Korevaar JC, Schellevis FG, Albreht T, Burgers JS.Evidence-based recommendations on care for breast cancer survivors for primary care providers: a review of evidence-based breast cancer guidelines. BMJ Open. 2017 Dec 12;7(12):e015118 (VUmc) 525. The European Low-Grade Glioma Network.Evidenced-based medicine in glioma: molecular biology is only part of the story. Lancet Oncology. 2017 Sep;18(9):E510-E510 (VUmc) 526. Lansaat L, van den Boer C, Muller SH, van der Noort V, van den Brekel MWM, Hilgers FJM.Ex vivo humidifying capacity and patient acceptability of stoma cloths in laryngectomized individuals. Head Neck 2017; 39:921-31 (NKI-AvL) 527. Lilly CL, Villa NY, Lemos de Matos A, Ali HM, Dhillon J-KS, Hofland T, Rahman MM, Chan W, Bogen B, Cogle C, McFadden G.Ex Vivo Oncolytic Virotherapy with Myxoma Virus Arms Multiple Allogeneic Bone Marrow Transplant Leukocytes to Enhance Graft versus Tumor.Molecular therapy oncolytics.2017;4():31- 40 (AMC) 528. Franke V, Scholtens WF, von Rosenstiel IA, Walenkamp MJ.Exogenous Cushing's syndrome due to a Chinese herbalist's prescription of ointment containing dexamethasone. BMJ Case Rep 2017; Apr 20:??? (NKI-AvL)

114 - Scientific publications 529. Guikema JEJ, Amiot M, Eldering EF.Exploiting the pro-apoptotic function of NOXA as a therapeutic modality in cancer.Expert opinion on therapeutic targets.2017;21(8):767-779 (AMC) 530. Lucas JS, Evans HJ, Haarman EG, Hirst RA, Hogg C, Jackson CL et al.Exploring the Art of Ciliary Beating: The Benefits of High-Speed Video Analysis. Chest. 2017 Dec 1;152(6):1348-1349 (VUmc) 531. Verheijen RB, Swart LE, Beijnen JH, Schellens JHM, Huitema ADR, Steeghs N.Exposure-survival analyses of pazopanib in renal cell carcinoma and soft tissue sarcoma patients: opportunities for dose optimization. Cancer Chemother Pharmacol 2017; 80:1171-8 (NKI-AvL) 532. van Erp AEM, Versleijen-Jonkers YMH, Hillebrandt-Roeffen MHS, van Houdt L, Gorris MAJ, van Dam LS, Mentzel T, Weidema ME, Savci Heijink CD, Desar IME, Merks HHM, van Noesel MM, Shipley J, van der Graaf WTA, Flucke UE, Meyer-Wentrup FAG.Expression and clinical association of programmed cell death-1, programmed death-ligand-1 and CD8(+) lymphocytes in primary sarcomas is subtype dependent.Oncotarget.2017;8(41):71371-71384 (AMC) 533. Tangen IL, Kopperud RK, Visser NC, Staff AC, Tingulstad S, Marcickiewicz J, Amant F, Bjorge L, Pijnenborg JM, Salvesen HB, Werner HM, Trovik J, Krakstad C.Expression of L1CAM in curettage or high L1CAM level in preoperative blood samples predicts lymph node metastases and poor outcome in endometrial cancer patients. Br J Cancer 2017; 117:840-7 (NKI-AvL) 534. Ottenhof SR, Djajadiningrat RS, de Jong J, Thygesen HH, Horenblas S, Jordanova ES.Expression of Programmed Death Ligand 1 (PD-L1) in penile cancer is of prognostic value and associated with HPV status. J Urol 2017; 197:690-7 (NKI-AvL, VUmc) 535. Tjan-Heijnen VCG, van Hellemond IEG, Peer PGM, Swinkels ACP, Smorenburg CH, van der Sangen MJC, Kroep JR, De Graaf H, Honkoop AH, Erdkamp FLG, van den Berkmortel FWPJ, de Boer M, de Roos WK, Linn SC, Imholz ALT, Seynaeve CM.Extended adjuvant aromatase inhibition after sequential endocrine therapy (DATA): a randomised, phase 3 trial. Lancet Oncol 2017; 18:1502-11 (NKI-AvL) 536. Veldhuijzen van Zanten SEM, Lane A, Heymans MW, Baugh J, Chaney B, Hoffman LM et al.External validation of the diffuse intrinsic pontine glioma survival prediction model: a collaborative report from the International DIPG Registry and the SIOPE DIPG Registry. Journal of Neuro-Oncology. 2017 Aug 1;134(1):231-240(AMC, VUmc) 537. Rondinelli B, Gogola E, Yucel H, Duarte AA, van de Ven M, van der Sluijs R, Konstantinopoulos PA, Jonkers J, Ceccaldi R, Rottenberg S, D'Andrea AD.EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation. Nat Cell Biol 2017; 19:1371-8 (NKI-AvL) 538. Schoot RA, Hol MLF, Merks JHM, Suttie M, Slater O, van Lennep M, Hopman SMJ, Dunaway D, Syme-Grant J, Smeele LE, Zwinderman KH, Caron HN, Hammond P.Facial asymmetry in head and neck rhabdomyosarcoma survivors. Pediatr Blood Cancer 2017; 64:e26508 (8 pp) (AMC,NKI-AvL) 539. Konings IC, Harinck F, Kuenen MA, Sidharta GN, Kieffer JM, Aalfs CM, Poley JW, Smets EM, Wagner A, van Rens A, Vleggaar FP, Ausems MG, Fockens P, van Hooft JE, Bruno MJ, Bleiker EMA.Factors associated with cancer worries in individuals participating in annual pancreatic cancer surveillance. Fam Cancer 2017; 16:143-51 (AMC,NKI-AvL) 540. Hummel SB, Hahn DEE, van Lankveld JJDM, Oldenburg HSA, Broomans E, Aaronson NK.Factors Associated With Specific Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Sexual Dysfunctions in Breast Cancer Survivors: A Study of Patients and Their Partners. J Sex Med 2017; 14:1248-59 (NKI-AvL) 541. Steinberg JD, Vogel W, Vegt E.Factors influencing brown fat activation in FDG PET/CT: a retrospective analysis of 15,000+ cases. Br J Radiol 2017;20170093 (NKI-AvL) 542. de Rooij BH, Ezendam NP, Nicolaije KA, Vos MC, Pijnenborg JM, Boll D, Kruitwagen RA, van de Poll- Franse LV.Factors influencing implementation of a survivorship care plan-a quantitative process evaluation of the ROGY Care trial. J Cancer Surviv 2017; 11:64-73 (NKI-AvL) 543. Busweiler LA, Henneman D, Dikken JL, Fiocco M, van Berge Henegouwen MI, Wijnhoven BP et al.Failure- to-rescue in patients undergoing surgery for esophageal or gastric cancer. European Journal of Surgical Oncology. 2017 Oct 1;43(10):1962-1969(AMC, NKI-AvL, VUmc) 544. Rodríguez E, Kalay H, Noya V, Brossard N, Giacomini C, van Kooyk Y et al.Fasciola hepatica glycoconjugates immuneregulate dendritic cells through the Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin inducing T cell anergy. Scientific Reports. 2017 Apr 24;7:46748 (VUmc) 545. de Krou S, Rosing H, Nuijen B, Schellens JHM, Beijnen JH.Fast and adequate liquid chromatography- tandem mass spectrometric determination of Z-endoxifen serum levels for therapeutic drug monitoring. Ther Drug Monit 2017; 39:132-7 (NKI-AvL) 546. Houthuijzen JM, Oosterom I, Hudson BD, Hirasawa A, Daenen LG, McLean CM, Hansen SV, van Jaarsveld MT, Peeper DS, Jafari Sadatmand S, Roodhart JM, van de Lest CH, Ulven T, Ishihara K, Milligan G, Voest EE.Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance. FASEB J 2017; 31:2195-209 (NKI-AvL) 547. van de Putte EEF, Vegt E, Mertens LS, Bruining A, Hendricksen K, van der Heijden MS et al.FDG-PET/CT for response evaluation of invasive bladder cancer following neoadjuvant chemotherapy. INTERNATIONAL UROLOGY AND NEPHROLOGY. 2017 Sep;49(9):1585-1591(NKI-AvL, VUmc) 548. Kwakman JJM, Vink G, Vestjens JH, Beerepoot LV, de Groot JW, Jansen RL, Opdam FL, Boot H, Creemers GJ, van Rooijen JM, Los M, Vulink AJE, Schut H, van Meerten E, Baars A, Hamberg P, Kapiteijn E, Sommeijer DW, Punt CJA, Koopman M.Feasibility and effectiveness of trifluridine/tipiracil in metastatic colorectal cancer: real-life data from The Netherlands.International journal of clinical oncology / Japan Society of Clinical Oncology.2017 (AMC)

Scientific publications - 115 549. Leensen MCJ, Groeneveld IF, Rejda T, Groenenboom P, van Berkel S, Brandon T, de Boer AGEM, Frings- Dresen MHW.Feasibility of a multidisciplinary intervention to help cancer patients return to work.European journal of cancer care.2017 (AMC) 550. Swager A-Fé, de Groof AJ, Meijer SL, Weusten BL, Curvers WL, Bergman JJGHM.Feasibility of laser marking in Barrett's esophagus with volumetric laser endomicroscopy: first-in-man pilot study.Gastrointestinal endoscopy.2017;86(3):464-472 (AMC) 551. Schermers B, van der Hage JA, Loo CE, Vrancken Peeters MTFD, Winter-Warnars HAO, van Duijnhoven F, Ten Haken B, Muller SH, Ruers TJM.Feasibility of magnetic marker localisation for non-palpable breast cancer. Breast 2017; 33:50-6 (NKI-AvL) 552. Kok HP, Korshuize-van Straten L, Bakker A, de Kroon-Oldenhof R, Westerveld GH, Versteijne E, Stalpers LJA, Crezee J.Feasibility of on-line temperature-based hyperthermia treatment planning to improve tumour temperatures during locoregional hyperthermia.International journal of hyperthermia.2017;():1- 10 (AMC) 553. McNeill NA, Kors WA, Bosscha MI, van Dijk J, Fabius AWM, Houffelaar T et al.Feasibility of RetinoQuest: e-health application to facilitate and improve additional care for retinoblastoma survivors. Journal of Cancer Survivorship. 2017 Dec 1;11(6):683-690 (VUmc) 554. Bijnsdorp IV, Maxouri O, Kardar A, Schelfhorst T, Piersma SR, Pham TV et al.Feasibility of urinary extracellular vesicle proteome profiling using a robust and simple, clinically applicable isolation method. Journal of Extracellular Vesicles. 2017;6(1):1313091 (VUmc) 555. Kraal KCJM, Bleeker GM, van Eck-Smit BLF, van Eijkelenburg NKA, Berthold F, van Noesel MM, Caron HN, Tytgat GAM.Feasibility, toxicity and response of upfront metaiodobenzylguanidine therapy therapy followed by German Pediatric Oncology Group Neuroblastoma 2004 protocol in newly diagnosed stage 4 neuroblastoma patients.European journal of cancer (Oxford, England.2017;76():188-196 (AMC) 556. Grobbee EéJ, Wieten E, Hansen BE, Stoop EM, de Wijkerslooth TR, Lansdorp-Vogelaar I, Bossuyt PMM, Dekker E, Kuipers EJ, Spaander MCW.Fecal immunochemical test-based colorectal cancer screening: The gender dilemma.United European gastroenterology journal.2017;5(3):448-454 (AMC) 557. van Overveld LFJ, Takes RP, Vijn TW, Braspenning JCC, de Boer JP, Brouns JJA et al.Feedback preferences of patients, professionals and health insurers in integrated head and neck cancer care. Health Expectations. 2017 Dec 1;20(6):1275-1288(AMC, NKI-AvL, VUmc) 558. Kuiken NSS, Rings EHHM, van den Heuvel-Eibrink MM, van de Wetering MD, Tissing WJE.Feeding strategies in pediatric cancer patients with gastrointestinal mucositis: a multicenter prospective observational study and international survey.Supportive care in cancer.2017;25(10):3075-3083 (AMC) 559. de Reijke TM.FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study EDITORIAL COMMENTS.Journal of urology.2017;197(6):1417 (AMC) 560. Leary AF, Quinn M, Fujiwara K, Coleman RL, Kohn E, Sugiyama T, Glasspool R, Ray-Coquard I, Colombo N, Bacon M, Zeimet A, Westermann AMM, Gomez-Garcia E, Provencher D, Welch S, Small W, Millan D, Okamoto A, Stuart G, Ochiai K.Fifth Ovarian Cancer Consensus Conference of the Gynecologic Cancer InterGroup (GCIG): clinical trial design for rare ovarian tumours.Annals of oncology.2017;28(4):718-726 (AMC) 561. Hamid O, Puzanov I, Dummer R, Schachter J, Daud A, Schadendorf D, Blank C, Cranmer LD, Robert C, Pavlick AC, Gonzalez R, Hodi FS, Ascierto PA, Salama AKS, Margolin KA, Gangadhar TC, Wei Z, Ebbinghaus S, Ibrahim N, Ribas A.Final analysis of a randomised trial comparing pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory advanced melanoma. Eur J Cancer 2017; 86:37-45 (NKI-AvL) 562. Van den Block L, Ko W, Miccinesi G, Moreels S, Donker GA, Onwuteaka-Philipsen B et al.Final transitions to place of death: patients and families wishes. Journal of public health (Oxford, England). 2017 Dec 1;39(4):e302-e311 (VUmc) 563. Groen EJ, Elshof LE, Visser LL, Rutgers EJT, Winter-Warnars HA, Lips EH, Wesseling J.Finding the balance between over- and under-treatment of ductal carcinoma in situ (DCIS). Breast 2017; 31:274-83 (NKI-AvL) 564. Schepers SA, Sint Nicolaas SM, Maurice-Stam H, van Dijk-Lokkart EM, van den Bergh EMM, de Boer N et al.First experience with electronic feedback of the Psychosocial Assessment Tool in pediatric cancer care. Supportive Care in Cancer. 2017 Oct 1;25(10):3113-3121(AMC, VUmc) 565. Smeenge M, Tranquart Fç, Mannaerts CK, de Reijke TM, van de Vijver MJ, Laguna Pes MP, Pochon S, Delarosette JJMCH, Wijkstra H.First-in-Human Ultrasound Molecular Imaging With a VEGFR2-Specific Ultrasound Molecular Contrast Agent (BR55) in Prostate Cancer A Safety and Feasibility Pilot Study.Investigative radiology.2017;52(7):419-427 (AMC) 566. Carbone DP, Reck M, Paz-Ares L, Creelan B, Horn L, Steins M, Felip E, van den Heuvel MM, Ciuleanu TE, Badin F, Ready N, Hiltermann TJN, Nair S, Juergens R, Peters S, Minenza E, Wrangle JM, Rodriguez- Abreu D, Borghaei H, Blumenschein GR, Jr , Villaruz LC, Havel L, Krejci J, Corral Jaime J, Chang H, Geese WJ, Bhagavatheeswaran P, Chen AC, Socinski MA, Collaborators (140), van den Heuvel MM.First- Line Nivolumab in Stage IV or Recurrent Non-Small-Cell Lung Cancer. N Engl J Med 2017; 376:2415-26 [Comment] (NKI-AvL) 567. Poorthuis MHF, Vernooij RWM, van Moorselaar RJA, de Reijke TM.First-line non-cytotoxic therapy in chemotherapy-naive patients with metastatic castration-resistant prostate cancer: a systematic review of 10 randomised clinical trials. BJU International. 2017 Jun;119(6):831-845(AMC, VUmc)

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Liem EIML, Baard J, Cauberg ECC, Bus MTJ, de Bruin DM, Laguna Pes MP, Delarosette JJMCH, de Reijke TM.Fluorescence in situ hybridization as prognostic predictor of tumor recurrence during treatment with Bacillus Calmette-Guerin therapy for intermediate- and high-risk non-muscleinvasive bladder cancer.Medical oncology (Northwood, London, England).2017;34(10):172 (AMC) 573. Van Den Wyngaert T, Helsen N, Carp L, Hakim S, Martens MJ, Hutsebaut I et al.Fluorodeoxyglucose- positron emission tomography/computed tomography after concurrent chemoradiotherapy in locally advanced head-and-neck squamous cell cancer: The ECLYPS study. Journal of Clinical Oncology. 2017 Oct 20;35(30):3458-3464 (VUmc) 574. 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Nature 2017; 546:307-11 (NKI-AvL) 597. Carretta M, de Boer B, Jaques J, Antonelli A, Horton SJ, Yuan H et al.Genetically engineered mesenchymal stromal cells produce IL-3 and TPO to further improve human scaffold-based xenograft models. Experimental Hematology. 2017 Jul;51:36-46 (VUmc) 598. Kersten K, de Visser KE, van Miltenburg MH, Jonkers J.Genetically engineered mouse models in oncology research and cancer medicine. EMBO Mol Med 2017; 9:137-53 (NKI-AvL) 599. Yanez-Cuna JO, van Steensel B.Genome-nuclear lamina interactions: from cell populations to single cells. Curr Opin Genet Dev 2017; 43:67-72 (NKI-AvL) 600. Verlaat W, Snijders PJF, Novianti PW, Wilting SM, De Strooper LMA, Trooskens G et al.Genome-wide DNA methylation profiling reveals methylation markers associated with 3q gain for detection of cervical precancer and cancer. 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Day FR, Thompson DJ, Helgason H, Chasman DI, Finucane H, Sulem P, Ruth KS, Whalen S, Sarkar AK, Albrecht E, Altmaier E, Amini M, Barbieri CM, Boutin T, Campbell A, Demerath E, Giri A, He C, Hottenga JJ, Karlsson R, Kolcic I, Loh PR, Lunetta KL, Mangino M, Marco B, McMahon G, Medland SE, Nolte IM, Noordam R, Nutile T, Paternoster L, Perjakova N, Porcu E, Rose LM, Schraut KE, Segre AV, Smith AV, Stolk L, Teumer A, Andrulis IL, Bandinelli S, Beckmann MW, Benitez J, Bergmann S, Bochud M, Boerwinkle E, Bojesen SE, Bolla MK, Brand JS, Brauch H, Brenner H, Broer L, Bruning T, Buring JE, Campbell H, Catamo E, Chanock S, Chenevix-Trench G, Corre T, Couch FJ, Cousminer DL, Cox A, Crisponi L, Czene K, Davey Smith G, de Geus EJCN, de Mutsert R, De Vivo I, Dennis J, Devilee P, Dos- Santos-Silva I, Dunning AM, Eriksson JG, Fasching PA, Fernandez-Rhodes L, Ferrucci L, Flesch-Janys D, Franke L, Gabrielson M, Gandin I, Giles GG, Grallert H, Gudbjartsson DF, Guenel P, Hall P, Hallberg E, Hamann U, Harris TB, Hartman CA, Heiss G, Hooning MJ, Hopper JL, Hu F, Hunter DJ, Ikram MA, Im HK, Jarvelin MR, Joshi PK, Karasik D, Kellis M, Kutalik Z, LaChance G, Lambrechts D, Langenberg C, Launer LJ, Laven JSE, Lenarduzzi S, Li J, Lind PA, Lindstrom S, Liu Y, Luan J, Magi R, Mannermaa A, Mbarek H, McCarthy MI, Meisinger C, Meitinger T, Menni C, Metspalu A, Michailidou K, Milani L, Milne RL, Montgomery GW, Mulligan AM, Nalls MA, Navarro P, Nevanlinna H, Nyholt DR, Oldehinkel AJ, O'Mara TA, Padmanabhan S, Palotie A, Pedersen N, Peters A, Peto J, Pharoah PDP, Pouta A, Radice P, Rahman I, Ring SM, Robino A, Rosendaal FR, Rudan I, Rueedi R, Ruggiero D, Sala CF, Schmidt MK, Scott RA, Shah M, Sorice R, Southey MC, Sovio U, Stampfer M, Steri M, Strauch K, Tanaka T, Tikkanen E, Timpson NJ, Traglia M, Truong T, Tyrer JP, Uitterlinden AG, Edwards DRV, Vitart V, Volker U, Vollenweider P, Wang Q, Widen E, van Dijk KW, Willemsen G, Winqvist R, Wolffenbuttel BHR, Zhao JH, Zoledziewska M, Zygmunt M, Alizadeh BZ, Boomsma DI, Ciullo M, Cucca F, Esko T, Franceschini N, Gieger C, Gudnason V, Hayward C, Kraft P, Lawlor DA, Magnusson PKE, Martin NG, Mook-Kanamori DO, Nohr EA, Polasek O, Porteous D, Price AL, Ridker PM, Snieder H, Spector TD, Stockl D, Toniolo D, Ulivi S, Visser JA, Volzke H, Wareham NJ, Wilson JF, Spurdle AB, Thorsteindottir U, Pollard KS, Easton DF, Tung JY, Chang-Claude J, Hinds D, Murray A, Murabito JM, Stefansson K, Ong KK, Perry JRB.Genomic analyses identify hundreds of

118 - Scientific publications variants associated with age at menarche and support a role for puberty timing in cancer risk. Nat Genet 2017; 49:834-41 (NKI-AvL) 603. Stevens-Kroef MJ, Olde Weghuis D, ElIdrissi-Zaynoun N, van der Reijden B, Cremers EMP, Alhan C et al.Genomic array as compared to karyotyping in myelodysplastic syndromes in a prospective clinical trial. Genes Chromosomes and Cancer. 2017 Jul 1;56(7):524-534 (VUmc) 604. Roumeliotis TI, Williams SP, Goncalves E, Alsinet C, Castillo Velasco-Herrera M, Aben N, Ghavidel FZ, Michaut M, Schubert M, Price S, Wright JC, Yu L, Yang M, Dienstmann R, Guinney J, Beltrao P, Brazma A, Pardo M, Stegle O, Adams DJ, Wessels L, Saez-Rodriguez J, McDermott U, Choudhary JS.Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells. Cell Rep 2017; 20:2201-14 (NKI- AvL) 605. Kooi IE, van Mil SE, MacPherson D, Mol BM, Moll AC, Meijers-Heijboer H, Kaspers GJ, Cloos J, Te Riele H, Dorsman JC.Genomic landscape of retinoblastoma in Rb-/- p130-/- mice resembles human retinoblastoma. Genes Chromosomes Cancer 2017; 56:231-42 (NKI-AvL, VUmc) 606. Pindyurin AV.Genomic mapping of chromatin proteins by using Daminv modification of an FLP-dependent DamID approach. Dokl Biochem Biophys 2017; 472:15-8 (NKI-AvL) 607. Bertholee D, Maring JG, van Kuilenburg ABP.Genotypes Affecting the Pharmacokinetics of Anticancer Drugs.Clinical pharmacokinetics.2017;56(4):317-337 (AMC) 608. Tang DH, Yan S, Ottenhof SR, Draeger D, Baumgarten AS, Chipollini J, Protzel C, Zhu Y, Ye DW, Hakenberg OW, Horenblas S, Watkin NA, Spiess PE.Glansectomy as Primary Management of Penile Squamous Cell Carcinoma: an International Study Collaboration. Urology 2017; 109:140-4 (NKI-AvL) 609. Hussein AA, Helder MN, de Visscher JG, Leemans CR, Braakhuis BJ, de Vet HCW et al.Global incidence of oral and oropharynx cancer in patients younger than 45 years versus older patients: A systematic review. European Journal of Cancer. 2017 Sep 1;82:115-127 (VUmc) 610. Dube S, van de Kamer JB, Rong Y.Globalism versus Nationalism in Medical Physics. J Appl Clin Med Phys 2017; 18:5-8 [Editorial] (NKI-AvL) 611. Polman NJ, Uijterwaal MH, Witte BI, Berkhof J, van Kemenade FJ, Spruijt JWM et al.Good performance of p16/ki-67 dual-stained cytology for surveillance of women treated for high-grade CIN. International Journal of Cancer. 2017 Jan 15;140(2):423-430 (VUmc) 612. Dahele M, Tol J.Google Trends can provide objective data on the impact of radiation oncology related media events and the level of interest in specific types of treatment. Radiotherapy and Oncology. 2017 Jul;124(1):182-183 (VUmc) 613. Lopes R, Agami R, Korkmaz G.GRO-seq, A Tool for Identification of Transcripts Regulating Gene Expression. Methods Mol Biol 2017; 1543:45-55 (NKI-AvL) 614. Dozeman E, Verdonck-de Leeuw IM, Savard J, van Straten A.Guided web-based intervention for insomnia targeting breast cancer patients: Feasibility and effect. Internet Interventions. 2017 Sep 1;9:1-6 (VUmc) 615. Minnema MC, Kimby E, D'Sa S, Fornecker L-M, Poulain Sé, Snijders TJ, Kastritis E, Kremer Sé, Fitsiori A, Simon L, Davi Féé, Lunn M, Castillo JJ, Patterson CJ, Le Garff-Tavernier M, Costopoulos M, Leblond Vé, Kersten MJ, Dimopoulos MA, Treon SP.Guideline for the diagnosis, treatment and response criteria for Bing-Neel syndrome.Haematologica.2017;102(1):43-51 (AMC) 616. 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Scientific publications - 119 617. Lakenman P, Ottens-Oussoren K, Witvliet-Van Nierop J, Van Der Peet D, De Van Der Schueren M.Handgrip Strength Is Associated with Treatment Modifications during Neoadjuvant Chemoradiation in Patients with Esophageal Cancer. Nutrition in Clinical Practice. 2017 Oct 1;32(5):652-657 (VUmc) 618. Loregger A, Raaben M, Tan J, Scheij S, Moeton M, van den Berg M, Gelberg-Etel H, Stickel E, Roitelman J, Brummelkamp T, Zelcer N.Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis. Arterioscler Thromb Vasc Biol 2017; 37:2064-74 (NKI-AvL) 619. Stouthard J, Brom L, Buiting HM.Having a Conversation With a Patient With Incurable Cancer-Just Another Protocol? JAMA Oncol 2017; 3:1305-6 [Viewpoint].(NKI-AvL) 620. Qendri V, Bogaards JA, Berkhof J.Health and economic impact of a tender-based, sex-neutral human papillomavirus 16/18 vaccination program in the Netherlands. Journal of Infectious Diseases. 2017 Jul 15;216(2):210-219 (VUmc) 621. Woudstra AJ, Timmermans DëRM, Uiters E, Dekker E, Smets EMA, Fransen MP.Health literacy skills for informed decision making in colorectal cancer screening: Perceptions of screening invitees and experts.Health expectations.2017 (AMC) 622. Persoon S, Kersten MJ, Buffart LM, Vander Slagmolen G, Baars JW, Visser O et al.Health-related physical fitness in patients with multiple myeloma or lymphoma recently treated with autologous stem cell transplantation. Journal of Science and Medicine in Sport. 2017 Feb 1;20(2):116-122(AMC, NKI-AvL, VUmc) 623. Pavel ME, Singh S, Strosberg JR, Bubuteishvili-Pacaud L, Degtyarev E, Neary MP, Carnaghi C, Tomasek J, Wolin E, Raderer M, Lahner H, Valle JW, Pommier R, Van Cutsem E, Tesselaar MET, Fave GD, Buzzoni R, Hunger M, Eriksson J, Cella D, Ricci JF, Fazio N, Kulke MH, Yao JC.Health-related quality of life for everolimus versus placebo in patients with advanced, non-functional, well-differentiated gastrointestinal or lung neuroendocrine tumours (RADIANT-4): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol 2017; 18:1411-22 (NKI-AvL) 624. Fardell JE, Vetsch J, Trahair T, Mateos MK, Grootenhuis MA, Touyz LM, Marshall GM, Wakefield CE.Health-related quality of life of children on treatment for acute lymphoblastic leukemia: A systematic review.Pediatric blood & cancer.2017;64(9): (AMC) 625. Zamanipoor Najafabadi AH, Peeters MCM, Lobatto DJ, Broekman MLD, Smith TR, Biermasz NR et al.Health-related quality of life of cranial WHO grade I meningioma patients: are current questionnaires relevant? Acta Neurochirurgica.. 2017 Nov 1;159(11):2149-2159 (VUmc) 626. Limperg PF, Terwee CB, Young NL, Price VE, Gouw SC, Peters M et al.Health-related quality of life questionnaires in individuals with haemophilia: a systematic review of their measurement properties. Haemophilia. 2017 Jul 1;23(4):497-510 (VUmc) 627. Clemens E, de Vries ACH, am Zehnhoff-Dinnesen A, Tissing WJE, Loonen JJ, Pluijm SFM et al.Hearing loss after platinum treatment is irreversible in noncranial irradiated childhood cancer survivors. Pediatric Hematology and Oncology. 2017 Feb 17;34(2):120-129(AMC, VUmc) 628. Stam B, van der Bijl E, van Diessen J, Rossi MMG, Tijhuis A, Belderbos JSA, Damen E, Sonke JJ.Heart dose associated with overall survival in locally advanced NSCLC patients treated with hypofractionated chemoradiotherapy. Radiother Oncol 2017; 125:62-5 (NKI-AvL) 629. Braamse AMJ, van Meijel B, Visser OJ, Huijgens PC, Beekman ATF, Dekker J.Help-seeking behaviour of patients with haematological malignancies treated with autologous stem cell transplantation. European Journal of Cancer Care. 2017 Sep;26(5) (VUmc) 630. van Rosmalen BV, Verheij J, Phoa SSKS, van Gulik TM.Hepatic epithelioid haemangioendothelioma (HEHE): a diagnostic dilemma between haemangioma and angiosarcoma.BMJ case reports.2017;2017(): (AMC) 631. Slijepcevic D, Roscam Abbing RLP, Katafuchi T, Blank A, Donkers JM, van Hoppe S, de Waart DR, Tolenaars D, van der Meer JHM, Wildenberg M, Beuers U, Oude Elferink RPJ, Schinkel AH, van de Graaf SFJ.Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice. Hepatology 2017; 66:1631-43 (NKI-AvL) 632. Olthof PB, Huiskens J, Schulte NR, Wicherts DA, Besselink MGH, Busch ORC, Tanis PJ, van Gulik TM.Hepatic vascular inflow occlusion is associated with reduced disease free survival following resection of colorectal liver metastases.European journal of surgical oncology.2017;43(1):100-106 (AMC) 633. 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Scientific publications - 127 776. Fay F, Hansen L, Hectors SJCG, Sanchez-Gaytan BL, Zhao Y, Tang J, Munitz J, Alaarg A, Braza MS, Gianella A, Aaronson SA, Reiner T, Kjems J, Langer R, Hoeben FJM, Janssen HM, Calcagno C, Strijkers GJ, Fayad ZA, Perez-Medina C, Mulder WJM.Investigating the Cellular Specificity in Tumors of a Surface- Converting Nanoparticle by Multimodal Imaging.Bioconjugate chemistry.2017;28(5):1413-1421 (AMC) 777. Feng YCA, Cho K, Lindstrom S, Kraft P, Cormack J, IGAP Consortium, Colorectal Transdisciplinary Study (CORECT) et al.Investigating the genetic relationship between Alzheimer’s disease and cancer using GWAS summary statistics. Human Genetics. 2017 Oct 1;136(10):1341-1351 (VUmc) 778. 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130 - Scientific publications 837. Teepen JC, Kremer LCM, Ronckers CM, Van Leeuwen FE, Hauptmann M, Van Dulmen-Den Broeder E et al.Long-term risk of subsequent malignant neoplasms after treatment of childhood cancer in the DCOG LATER study cohort: Role of chemotherapy. Journal of Clinical Oncology. 2017 Jul 10;35(20):2288- 2298(NKI-AvL, VUmc) 838. Teepen JC, van Leeuwen FE, Tissing WJ, van Dulmen-den Broeder E, van den Heuvel-Eibrink MM, van der Pal HJH, Loonen JJ, Bresters D, Versluys B, Neggers SJCMM, Jaspers MWM, Hauptmann M, van der Heiden-van der Loo M, Visser O, Kremer LCM, Ronckers CM.Long-Term Risk of Subsequent Malignant Neoplasms After Treatment of Childhood Cancer in the DCOG LATER Study Cohort: Role of Chemotherapy.Journal of clinical oncology.2017;35(20):2288-2298 (AMC) 839. Kuusk T, de Jong J, Grivas N, Horenblas S, Bex A.Long-Term Survival after Resection of Sentinel Node Metastatic Renal Cell Carcinoma. Urology 2017; 103:e5-e6 [Images] (NKI-AvL) 840. 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Scientific publications - 131 recommendations from the 2016 European Society of Gastrointestinal and Abdominal Radiology (ESGAR) consensus meeting.European radiology.2017 (AMC) 857. Bainbridge H, Salem A, Tijssen RHN, Dubec M, Wetscherek A, Van Es C, Belderbos J, Faivre-Finn C, McDonald F.Magnetic resonance imaging in precision radiation therapy for lung cancer. Transl Lung Cancer Res 2017; 6:689-707 (NKI-AvL) 858. Tetar S, Lagerwaard F, Palacios M, Haasbeek N, Bohoudi O, Slotman B et al.Magnetic Resonance Imaging-Guided Delivery of Lung Stereotactic Radiotherapy Using Patient-Controlled Visual Guidance. Journal of Thoracic Oncology. 2017 Jan;12(1):S420-S421 (VUmc) 859. Huijskens SC, van Dijk IWEM, Visser J, Rasch CRN, Alderliesten T, Bel A.Magnitude and variability of respiratory-induced diaphragm motion in children during image-guided radiotherapy.Radiotherapy and oncology.2017;123(2):263-269 (AMC) 860. 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132 - Scientific publications 877. Van Den Hout MFCM, Koster BD, Sluijter BJR, Molenkamp BG, Van De Ven R, Van Den Eertwegh AJM et al.Melanoma sequentially suppresses different DC subsets in the sentinel lymph node, affecting disease spread and recurrence. Cancer Immunology Research. 2017 Nov 1;5(11):969-977 (VUmc) 878. Van Leeuwaarde RS, Dreijerink KM, Ausems MG, Beijers HJ, Dekkers OM, De Herder WW et al.MEN1- dependent breast cancer: Indication for early screening? Results from the Dutch MEN1 study group. Journal of Clinical Endocrinology and Metabolism. 2017 Jun 1;102(6):2083-2090 (VUmc) 879. Joosten SPJ, Zeilstra J, van Andel H, Mijnals RC, Zaunbrecher J, Duivenvoorden AAM, van de Wetering M, Clevers H, Spaargaren M, Pals ST.MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms.Gastroenterology.2017;153(4):1040-+ (AMC) 880. Nijenhuis CM, Lucas L, Rosing H, Huitema ADR, Mergui-Roelvink M, Jamieson GC, Fox JA, Mould DR, Schellens JHM, Beijnen JH.Metabolism and disposition of the anticancer quinolone derivative vosaroxin, a novel inhibitor of topoisomerase II. Invest New Drugs 2017; 35:478-90 (NKI-AvL) 881. Coumans FAW, Brisson AR, Buzas EI, Dignat-George F, Drees EEE, El-Andaloussi S et al.Methodological Guidelines to Study Extracellular Vesicles. Circulation Research. 2017 May 12;120(10):1632-1648 (VUmc) 882. Kandimalla R, Linnekamp JF, van Hooff SR, Castells A, Llor X, Andreu M, Jover R, Goel A, Medema JP.Methylation of WNT target genes AXIN2 and DKK1 as robust biomarkers for recurrence prediction in stage II colon cancer.Oncogenesis.2017;6(4):e308 (AMC) 883. Wumkes ML, van der Velden AMT, de Bruin E, Meerveld-Eggink A, Koopmans MPG, Rimmelzwaan GF et al.Microarray profile of the humoral immune response to influenza vaccination in breast cancer patients treated with chemotherapy. 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134 - Scientific publications 918. Hupkens BJP, Maas M, Martens MH, Deserno WMLL, Leijtens JWA, Nelemans PJ, Bakers FCH, Lambregts DMJ, Beets GL, Beets-Tan RGH.MRI surveillance for the detection of local recurrence in rectal cancer after transanal endoscopic microsurgery. Eur Radiol 2017; 27:4960-9 (NKI-AvL) 919. Matse JH, Bharos WK, Veerman ECI, Bloemena E, Bolscher JGM.Mucoepidermoid carcinoma-associated expression of MUC5AC, MUC5B and mucin-type carbohydrate antigen sialyl-Tn in the parotid gland. Archives of Oral Biology. 2017 Oct 1;82:121-126 (VUmc) 920. Lalmahomed ZS, Coebergh van den Braak RRJ, Oomen MHA, Arshad SP, Riegman PHJ, IJzermans JNM et al.Multicenter fresh frozen tissue sampling in colorectal cancer: does the quality meet the standards for state of the art biomarker research? Cell and Tissue Banking.. 2017 Sep 1;18(3):425-431 (VUmc) 921. 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Eur J Surg Oncol 2017; 43:1740-5 (NKI-AvL) 943. van Veen M, Matas-Rico E, van de Wetering K, Leyton-Puig D, Kedziora KM, De Lorenzi V, Stijf-Bultsma Y, van den Broek B, Jalink K, Sidenius N, Perrakis A, Moolenaar WH.Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells. Elife 2017; 6:e23649 (20 pp) (NKI-AvL) 944. Trumpi K, Ubink I, Trinh A, Djafarihamedani M, Jongen JM, Govaert KM, Elias SG, van Hooff SR, Medema JP, Lacle MM, Vermeulen L, Borel Rinkes IHM, Kranenburg O.Neoadjuvant chemotherapy affects molecular classification of colorectal tumors.Oncogenesis.2017;6(7):e357 (AMC) 945. van Laarhoven HWM, van Berge Henegouwen MI, Hulshof MCCM.Neoadjuvant chemotherapy in oesophageal adenocarcinoma.lancet oncology.2017;18(11):e639 (AMC) 946. Borst GR, Kumareswaran R, Yucel H, Telli S, Do T, McKee T, Zafarana G, Jonkers J, Verheij M, O'Connor MJ, Rottenberg S, Bristow RG.Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model. Oncotarget 2017; 8:87638-46 (NKI-AvL) 947. Steenbruggen TG, van Ramshorst MS, Kok M, Linn SC, Smorenburg CH, Sonke GS.Neoadjuvant Therapy for Breast Cancer: Established Concepts and Emerging Strategies. Drugs 2017; 77:1313-36 (NKI-AvL) 948. Salihi R, Leunen K, Moerman P, Amant F, Neven P, Vergote I.Neoadjuvant Weekly Paclitaxel-Carboplatin Is Effective in Stage I-II Cervical Cancer. Int J Gynecol Cancer 2017; 27:1256-60 (NKI-AvL) 949. van Groningen TJB, Koster JJB, Valentijn LJ, Zwijnenburg DA, Akogul N, Hasselt NE, Broekmans MEC, Haneveld F, Nowakowska NE, Bras J, van Noesel CJM, Jongejan A, van Kampen AHC, Koster L, Baas F, van Dijk-Kerkhoven L, Huizer-Smit M, Lecca MC, Chan A, Lakeman A, Molenaar P, Volckmann R, Westerhout EM, Hamdi M, van Sluis PG, Ebus MEG, Molenaar JJ, Tytgat GAM, Westerman B, van Nes WJ, Versteeg R.Neuroblastoma is composed of two super-enhancer-associated differentiation states.Nature genetics.2017;49(8):1261-1266 (AMC) 950. Matas-Rico E, van Veen M, Moolenaar WH.Neuronal differentiation through GPI-anchor cleavage. Cell Cycle 2017; 16:388-9 [Editorial] (NKI-AvL) 951. Boele FW, van Uden-Kraan CF, Hilverda K, Weimer J, Donovan HS, Drappatz J et al.Neuro-oncology family caregivers’ view on keeping track of care issues using eHealth systems: it’s a question of time. Journal of Neuro-Oncology. 2017 Aug 1;134(1):157-167 (VUmc) 952. Shikhagaie MM, Björklund ÅK, Mjösberg J, Erjefält JS, Cornelissen AS, Ros XR et al.Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates. Cell Reports. 2017 Feb 14;18(7):1761-1773 (VUmc) 953. Garner H, de Visser KE.Neutrophils take a round-trip. Science 2017; 358:42-3 (NKI-AvL) 954. Giovannetti E, van der Borden CL, Frampton AE, Ali A, Firuzi O, Peters GJ.Never let it go: Stopping key mechanisms underlying metastasis to fight pancreatic cancer. Seminars in Cancer Biology. 2017 Jun 1;44:43-59 (VUmc) 955. Etienne-Grimaldi M-C, Boyer J-C, Beroud C, Mbatchi L, van Kuilenburg ABP, Bobin-Dubigeon C, Thomas F, Chatelut E, Merlin J-L, Pinguet Féé, Ferrand C, Meijer J, Evrard A, Llorca L, Romieu G, Follana P, Bachelot T, Chaigneau L, Pivot X, Dieras Vé, Largillier Ré, Mousseau M, Goncalves A, Roché H, Bonneterre J, Servent Vé, Dohollou N, Château Y, Chamorey E, Desvignes J-P, Salgado D, Ferrero J-M, Milano Gé.New advances in DPYD genotype and risk of severe toxicity under capecitabine.PLoS ONE.2017;12(5):e0175998 (AMC) 956. Haghiralsadat F, Amoabediny G, Sheikhha MH, Zandieh-doulabi B, Naderinezhad S, Helder MN et al.New liposomal doxorubicin nanoformulation for osteosarcoma: Drug release kinetic study based on thermo and pH sensitivity. Chemical Biology and Drug Design. 2017 Sep 1;90(3):368-379 (VUmc) 957. Baard J, Freund JE, Delarosette JJMCH, Laguna Pes MP.New technologies for upper tract urothelial carcinoma management.Current opinion in urology.2017;27(2):170-175 (AMC) 958. Vriend LEM, Krawczyk P.Nick-initiated homologous recombination: Protecting the genome, one strand at a time.DNA repair.2017;50():1-13 (AMC) 959. Hochhaus A, Mahon F-X, le Coutre P, Petrov L, Janssen JJWM, Cross NCP et al.Nilotinib first-line therapy in patients with Philadelphia chromosome-negative/BCR-ABL-positive chronic myeloid leukemia in chronic phase: ENEST1st sub-analysis. Journal of Cancer Research and Clinical Oncology. 2017 Jul;143(7):1225-1233 (VUmc) 960. Sopper S, Mustjoki S, Gjertsen BT, Giles F, Hochhaus A, Janssen JJWM et al.NK cell dynamics and association with molecular response in early chronic phase chronic myelogenous leukemia (CML-CP) patients treated with nilotinib. Leukemia. 2017 Oct 1;31(10):2264-2267 (VUmc) 961. Woestenberg PJ, King AJ, van der Sande MAB, Donken R, Leussink S, van der Klis FRM et al.No evidence for cross-protection of the HPV-16/18 vaccine against HPV-6/11 positivity in female STI clinic visitors. 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136 - Scientific publications 962. Lodge M, Boellaard R.Noise and bias characteristics of standardized uptake value (SUV) derived with point spread function (PSF) image reconstruction: should PSF be used for PET tumor uptake quantification. Journal of Nuclear Medicine. 2017 May 1;58 (VUmc) 963. Alsaid H, Skedzielewski T, Rambo MV, Hunsinger K, Hoang B, Fieles W et al.Non invasive imaging assessment of the biodistribution of GSK2849330, an ADCC and CDC optimized anti HER3 mAb, and its role in tumor macrophage recruitment in human tumor-bearing mice. PLoS One. 2017;12(4):e0176075 (VUmc) 964. den Bakker CM, Smit JK, Bruynzeel AME, van Grieken NCT, Daams F, Derks S et al.Non responders to neoadjuvant chemoradiation for esophageal cancer: Why better prediction is necessary. Journal of Thoracic Disease. 2017 Jul 1;9:S843-S850 (VUmc) 965. 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Scientific publications - 143 1097. Verheijen RB, Yu H, Schellens JHM, Beijnen JH, Steeghs N, Huitema ADR.Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology. Clin Pharmacol Ther 2017; 102:765-78 (NKI-AvL) 1098. Gezgin G, Luk SJ, Cao J, Dogrusoz M, van der Steen DM, Hagedoorn RS et al.PRAME as a Potential Target for Immunotherapy in Metastatic Uveal Melanoma. Jama ophthalmology. 2017 Jun;135(6):541-549 (VUmc) 1099. van Ginkel JH, van den Broek DA, van Kuik J, Linders D, de Weger R, Willems SM, Huibers MMH.Preanalytical blood sample workup for cell-free DNA analysis using Droplet Digital PCR for future molecular cancer diagnostics. Cancer Med 2017; 6:2297-307 (NKI-AvL) 1100. Sewing ACP, Lagerweij T, van Vuurden DG, Meel MH, Veringa SJE, Carcaboso AM et al.Preclinical evaluation of convection-enhanced delivery of liposomal doxorubicin to treat pediatric diffuse intrinsic pontine glioma and thalamic high-grade glioma. 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Scientific publications - 151 Spence R, Iqbal A, Khan A, Perrin K, Raza A, Tan S.Relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection: an international snapshot audit.Colorectal disease.2017;19(8):O296-O311 (AMC) 1218. Dahele M, Damhuis RA.Relationship Between Tumor Location and Outcome in Patients With Early-Stage Lung Cancer. Clinical Lung Cancer. 2017 Sep 1;18(5):e367-e368 (VUmc) 1219. De Jong A, Witting K, Kooij R, Flierman D, Ovaa H.Release of Enzymatically Active Deubiquitinating Enzymes upon Reversible Capture by Disulfide Ubiquitin Reagents. Angew Chem Int Ed Engl 2017; 56:12967-70 (NKI-AvL) 1220. Bense RD, Sotiriou C, Piccart-Gebhart MJ, Haanen JBAG, van Vugt MA, de Vries EGE, Schroder CP, Fehrmann RS.Relevance of Tumor-Infiltrating Immune Cell Composition and Functionality for Disease Outcome in Breast Cancer. J Natl Cancer Inst 2017; 109:djw192 (9 pp) (NKI-AvL) 1221. Farag S, van der Kolk LE, van Boven HH, van Akkooi ACJ, Beets GL, Wilmink JW, Steeghs N.Remarkable effects of imatinib in a family with young onset gastrointestinal stromal tumors and cutaneous hyperpigmentation associated with a germline KIT-Trp557Arg mutation: case report and literature overview.Familial cancer.2017 (AMC) 1222. Prins FM, Kerkmeijer LGW, Pronk AA, Vonken EPA, Meijer RP, Bex A, Barendrecht MM.Renal cell carcinoma: alternative nephron-sparing treatment options for small renal masses, a systematic review. J Endourol 2017; 31:963-75 (NKI-AvL) 1223. van Schie MA, Steenbergen P, Dinh CV, Ghobadi G, van Houdt PJ, Pos FJ, Heijmink SWTJ, van der Poel HG, Renisch S, Vik T, van der Heide UA.Repeatability of dose painting by numbers treatment planning in prostate cancer radiotherapy based on multiparametric magnetic resonance imaging. Phys Med Biol 2017; 62:5575-88 (NKI-AvL) 1224. Kramer GM, Hoekstra OS, Boellaard R.Repeatability of Quantitative Whole-Body F-18-FDG PET/CT Uptake Measures in Patients with Non-Small Cell Lung Cancer: Dynamic Versus Test-Retest Design REPLY. Journal of Nuclear Medicine. 2017 Sep;58(9):1528-1529 (VUmc) 1225. Vujanovic M, Krietsch J, Raso MC, Terraneo N, Zellweger R, Schmid JA, Taglialatela A, Huang JW, Holland CL, Zwicky K, Herrador R, Jacobs H, Cortez D, Ciccia A, Penengo L, Lopes M.Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity. Mol Cell 2017; 67:882-90 (NKI-AvL) 1226. de Bruijn RE, Bex A.Reply. Urology 2017; 109:132 [Letter]-133 (NKI-AvL) 1227. Madu M, Wouters MW, van Akkooi AC.Reply to "Current controversies on sentinel node biopsy in thin and thick cutaneous melanoma". Eur J Surg Oncol 2017; 43:508 [Letter] (NKI-AvL) 1228. Westerduin E, van Dieren S, Bemelman WA, Tanis PJ.Reply to "Redo coloanal anastomosis for anastomotic leakage after low anterior resection for rectal cancer; an analysis of 59 cases".Colorectal disease.2017 (AMC) 1229. Babjuk M, Burger M, Comperat E, Palou J, Roupret M, van Rhijn B, Shariat S, Sylvester R, Zigeuner R, Gontero P, Mostafid H.Reply to Harry Herr's Letter to the Editor re: Marko Babjuk, Andreas Bohle, Maximilian Burger, et al. EAU Guidelines on Non-muscle-invasive Urothelial Carcinoma of the Bladder: Update 2016. Eur Urol 2017; 71:e173-e174 [Letter] (NKI-AvL) 1230. Thunnissen E, Witte BI, Noguchi M, Yatabe Y.Reply to Letter “The Use of Immunohistochemistry Improves the Diagnosis of Small Cell Lung Cancer and Its Differential Diagnosis. Journal of Thoracic Oncology. 2017 Jun 1;12(6):e70-e71 (VUmc) 1231. Cataliotti L, Marotti L, Beishon M, Costa A, Knox S, Rutgers E, Cardoso F.Reply to letter from Suguatti et al. Eur J Cancer 2017; 87:201-2 [Letter] (NKI-AvL) 1232. Wentink MQ, Huijbers EJM, Timmerman P, Griffioen AW.Reply to Marchiò et al: Antitumor immune regulation by angiostatic therapy. Proceedings of the National Academy of Sciences of the United States of America. 2017 Apr 18;114(16):E3166-E3167 (VUmc) 1233. Schuurhuizen CSEW, Braamse AMJ, Konings IRHM, Sprangers MAG, Ket JCF, Dekker J et al.Reply to the letter to the editor 'Specific QOL scales that reflect toxicity-induced impairment are needed in RCTs'. Annals of Oncology. 2017 Aug 1;28(8):2033-2034 (VUmc) 1234. Schuurhuizen CSEW, Braamse AMJ, Konings IRHM, Sprangers MAG, Ket JCF, Dekker J, Verheul HMW.Reply to the letter to the editor 'Specific QOL scales that reflect toxicity-induced impairment are needed in RCTs'.Annals of oncology.2017;28(8):2033-2034 (AMC) 1235. Kist JW, de Keizer B, Hoekstra OS, Vogel WV.Reply: THYROPET study: is biology or technology the issue?.J Nucl Med 2017; 58:354-5 [Letter] (NKI-AvL) 1236. van der Putten LJM, Van de Vijver K, Bartosch C, Davidson B, Gatius S, Matias-Guiu X, McCluggage WG, Toledo G, van der Wurff AA, Pijnenborg JM, Massuger LF, Bulten J.Reproducibility of measurement of myometrial invasion in endometrial carcinoma. Virchows Arch 2017; 470:63-8 (NKI-AvL) 1237. Brouckaert O, Rudolph A, Laenen A, Keeman R, Bolla MK, Wang Q, Soubry A, Wildiers H, Andrulis IL, Arndt V, Beckmann MW, Benitez J, Blomqvist C, Bojesen SE, Brauch H, Brennan P, Brenner H, Chenevix- Trench G, Choi JY, Cornelissen S, Couch FJ, Cox A, Cross SS, Czene K, Eriksson M, Fasching PA, Figueroa J, Flyger H, Giles GG, Gonzalez-Neira A, Guenel P, Hall P, Hollestelle A, Hopper JL, Ito H, Jones M, Kang D, Knight JA, Kosma VM, Li J, Lindblom A, Lilyquist J, Lophatananon A, Mannermaa A, Manoukian S, Margolin S, Matsuo K, Muir K, Nevanlinna H, Peterlongo P, Pylkas K, Saajrang S, Seynaeve C, Shen CY, Shu XO, Southey MC, Swerdlow A, Teo SH, Tollenaar RAEM, Truong T, Tseng CC, van den Broek AJ, van Deurzen CHM, Winqvist R, Wu AH, Yip CH, Yu JC, Zheng W, Milne RL, Pharoah PDP, Easton DF, Schmidt

152 - Scientific publications MK, Garcia-Closas M, Chang-Claude J, Lambrechts D, Neven P.Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study. Breast Cancer Res 2017; 19:119 (12 pp) (NKI-AvL) 1238. van Gils N, Verhagen HJMP, Smit L.Reprogramming acute myeloid leukemia into sensitivity for retinoic- acid-driven differentiation. Experimental Hematology. 2017 Aug 1;52:12-23 (VUmc) 1239. Matos TR, de Rie MA, Teunissen MBM.Research Techniques Made Simple: High-Throughput Sequencing of the T-Cell Receptor.Journal of investigative dermatology.2017;137(6):e131-e138 (AMC) 1240. Matos TR, Liu H, Ritz J.Research Techniques Made Simple: Mass Cytometry Analysis Tools for Decrypting the Complexity of Biological Systems.Journal of investigative dermatology.2017;137(5):e43-e51 (AMC) 1241. Huang L, Jansen L, Balavarca Y, Molina-Montes E, Babaei M, van der Geest LGM, Lemmens V, van Eycken L, de Schutter H, Johannesen TB, Fristrup CW, Mortensen MB, Primic-Žakelj M, Zadnik V, Becker N, Hackert T, Mägi M, Cassetti T, Sassatelli R, Grützmann R, Merkel S, Gonçalves AF, Bento MJ, Hegyi Pé, Lakatos Gá, Szentesi A, Moreau M, van de Velde T, Broeks A, Sant M, Minicozzi P, Mazzaferro V, Real FX, Carrato A, Molero X, Besselink MGH, Malats Nú, Büchler MW, Schrotz-King P, Brenner H.Resection of pancreatic cancer in Europe and USA: an international large-scale study highlighting large variations.Gut.2017 (AMC) 1242. Van Der Steen N, Rolfo C, Pauwels P, De Langen AJ, Peters GJ, Giovannetti E.Resistance mechanisms to AZD9291 and rociletinib - Letter. Clinical Cancer Research. 2017 Jul 15;23(14):3966 (VUmc) 1243. Meijerink MR, Scheffer HJ.Response. Radiology. 2017 Aug 1;284(2):605 (VUmc) 1244. van Spronsen MF, Witte BI, Ossenkoppele GJ, Westers TM, van de Loosdrecht AA.Response to letter commenting on: Prognostic relevance of morphological classification models for myelodysplastic syndromes in an era of the revised International Prognostic Scoring System. European Journal of Cancer. 2017 Feb 1;72:269-271 (VUmc) 1245. van Harten W, IJzerman MJ.Responsible pricing in value-based assessment of cancer drugs: real-world data are an inevitable addition to select meaningful new cancer treatments. Ecancermedicalscience 2017; 11:ed71 [Editorial] (NKI-AvL) 1246. Peinemann F, van Dalen EC, Enk H, Berthold F.Retinoic acid postconsolidation therapy for high-risk neuroblastoma patients treated with autologous haematopoietic stem cell transplantation.Cochrane database of systematic reviews (Online).2017;2017(8):CD010685 (AMC) 1247. Russell NS, Krul IM, van Eggermond AM, Aleman BMP, Cooke R, Kuiper S, Allen SD, Wallis MG, Llanas D, Diallo I, de Vathaire F, Smith SA, Hauptmann M, Broeks A, Swerdlow AJ, van Leeuwen FE.Retrospective methods to estimate radiation dose at the site of breast cancer development after Hodgkin lymphoma radiotherapy. Clin Transl Radiat Oncol 2017; 7:20-7 (NKI-AvL) 1248. Leensen MCJ, Groeneveld IF, Heide IV, Rejda T, van Veldhoven PLJ, Berkel SV, Snoek A, van Harten W, Frings-Dresen MHW, de Boer AGEM.Return to work of cancer patients after a multidisciplinary intervention including occupational counselling and physical exercise in cancer patients: a prospective study in the Netherlands. BMJ Open 2017; 7:e014746 (AMC,NKI-AvL) 1249. Sollie A, Sijmons RH, Helsper C, Numans ME.Reusability of coded data in the primary care electronic medical record: A dynamic cohort study concerning cancer diagnoses. International Journal of Medical Informatics. 2017 Mar 1;99:45-52 (VUmc) 1250. de Boer LL, Spliethoff JW, Sterenborg HJCM, Ruers TJM.Review: in vivo optical spectral tissue sensing- how to go from research to routine clinical application?.Lasers Med Sci 2017; 32:711-9 (NKI-AvL) 1251. Verkooijen HM, Kerkmeijer LGW, Fuller CD, Huddart R, Faivre-Finn C, Verheij M, Mook S, Sahgal A, Hall E, Schultz C.R-IDEAL: A Framework for Systematic Clinical Evaluation of Technical Innovations in Radiation Oncology. Front Oncol 2017; 7:59 (7 pp) (NKI-AvL) 1252. Miok V, Wilting SM, van Wieringen WN.Ridge estimation of the VAR(1) model and its time series chain graph from multivariate time-course omics data. Biometrical Journal. 2017 Jan 1;59(1):172-191 (VUmc) 1253. Font-Gonzalez A, Feijen ELAM, Geskus RB, Dijkgraaf MGW, van der Pal HJH, Heinen RC, Jaspers MW, van Leeuwen FE, Reitsma JBJ, Caron HN, Sieswerda E, Kremer LC.Risk and associated risk factors of hospitalization for specific health problems over time in childhood cancer survivors: a medical record linkage study. Cancer Med 2017; 6:1123-34 (AMC,NKI-AvL) 1254. Rietbergen MM, Brakenhoff RH, Leemans CR.Risk groups for survival in HPV-positive and HPV-negative OPSCC. Recent Results in Cancer Research. 2017 Oct 1;206:221-231 (VUmc) 1255. Verloop J, van Leeuwen FE, Helmerhorst TJM, de Kok IMCM, van Erp EJM, van Boven HH, Rookus MA.Risk of cervical intra-epithelial neoplasia and invasive cancer of the cervix in DES daughters. Gynecol Oncol 2017; 144:305-11 (NKI-AvL) 1256. Molenaar RJ, Pleyer C, Radivoyevitch T, Sidana S, Godley A, Advani AS, Gerds AT, Carraway HE, Kalaycio M, Nazha A, Adelstein D, Nasr C, Angelini D, Maciejewski JP, Majhail N, Sekeres MA, Mukherjee S.Risk of developing chronic myeloid neoplasms in well-differentiated thyroid cancer patients treated with radioactive iodine.Leukemia.2017 (AMC) 1257. van Nimwegen FA, Ntentas G, Darby SC, Schaapveld M, Hauptmann M, Lugtenburg PJ, Janus CP, Daniels L, van Leeuwen FE, Cutter DJ, Aleman BMP.Risk of heart failure in survivors of Hodgkin lymphoma: effects of cardiac exposure to radiation and anthracyclines. Blood 2017; 129:2257-65 (NKI-AvL) 1258. Rijkers AP, Bakker OJ, Ahmed Ali U, Hagenaars JCJP, van Santvoort HC, Besselink MGH, Bollen TL, van Eijck CH.Risk of Pancreatic Cancer After a Primary Episode of Acute Pancreatitis.Pancreas.2017;46(8):1018-1022 (AMC)

Scientific publications - 153 1259. Belderbos TDG, Pullens HJM, Leenders M, Schipper MEI, Siersema PD, van Oijen MGH.Risk of post- colonoscopy colorectal cancer due to incomplete adenoma resection: A nationwide, population-based cohort study.United European gastroenterology journal.2017;5(3):440-447 (AMC) 1260. Bright CJ, Hawkins MM, Winter DL, Alessi D, Allodji RS, Bagnasco F, Bárdi E, Bautz A, Byrne J, Feijen LAM, Fidler MM, Garwicz S, Grabow D, Gudmundsdottir T, Guha J, Haddy N, Jankovic M, Kaatsch P, Kaiser M, Kuehni CE, Linge H, Øfstaas H, Ronckers CM, Skinner R, Teepen JC, Terenziani M, Vu-Bezin G, Wesenberg F, Wiebe T, Sacerdote C, Jakab Z, Haupt R, Lähteenmäki Pä, Zaletel LZ, Kuonen R, Winther JF, de Vathaire F, Kremer LCM, Hjorth L, Reulen RC.Risk of Soft-Tissue Sarcoma Among 69 460 Five-Year Survivors of Childhood Cancer in Europe.Journal of the National Cancer Institute.2017 (AMC) 1261. Kuchenbaecker KB, Hopper JL, Barnes DR, Phillips KA, Mooij TM, Roos-Blom MJ, Jervis S, van Leeuwen FE, Milne RL, Andrieu N, Goldgar DE, Terry MB, Rookus MA, Easton DF, Antoniou AC, McGuffog L, Evans DG, Barrowdale D, Frost D, Adlard J, Ong KR, Izatt L, Tischkowitz M, Eeles R, Davidson R, Hodgson S, Ellis S, Nogues C, Lasset C, Stoppa-Lyonnet D, Fricker JP, Faivre L, Berthet P, Hooning MJ, van der Kolk LE, Kets CM, Adank MA, John EM, Chung WK, Andrulis IL, Southey M, Daly MB, Buys SS, Osorio A, Engel C, Kast K, Schmutzler RK, Caldes T, Jakubowska A, Simard J, Friedlander ML, McLachlan SA, Machackova E, Foretova L, Tan YY, Singer CF, Olah E, Gerdes AM, Arver B, Olsson H.Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers. JAMA 2017; 317:2402-16 (NKI-AvL) 1262. Bosschieter J, Vis AéN, van der Poel HG, Moonen LM, Horenblas S, van Rhijn BWG, Pieters BR, Nieuwenhuijzen JA, Hendricksen K.Robot-assisted Laparoscopic Implantation of Brachytherapy Catheters in Bladder Cancer.European urology.2017 (AMC) 1263. Palacios M, Bohoudi O, Bruynzeel A, Slotman BJ, Lagerwaard F, Senan S.Role of Daily Plan Adaption during Breath-Hold MR-Guided Stereotactic Ablative Radiotherapy for Adrenal Metastases. International Journal of Radiation Oncology, Biology, Physics. 2017 Oct 1;99(2):S125-S126 (VUmc) 1264. Giovannetti E, Zucali PA, Assaraf YG, Funel N, Gemelli M, Stark M et al.Role of proton-coupled folate transporter in pemetrexed resistance of mesothelioma: Clinical evidence and new pharmacological tools. Annals of Oncology. 2017;28(11):2725-2732 (VUmc) 1265. Lacas B, Bourhis J, Overgaard J, Zhang Q, Gregoire V, Nankivell M, Zackrisson B, Szutkowski Z, Suwinski R, Poulsen M, O'Sullivan B, Corvo R, Laskar SG, Fallai C, Yamazaki H, Dobrowsky W, Cho KH, Garden AS, Langendijk JA, Viegas CMP, Hay J, Lotayef M, Parmar MKB, Auperin A, Van Herpen C, Maingon P, Trotti AM, Grau C, Pignon JP, Blanchard P.Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis. Lancet Oncol 2017; 18:1221-37 (NKI-AvL) 1266. Hilkens J, Timmer N, Boer M, Ikink G, Schewe M, Sacchetti A, Koppens M, Song J, Bakker E.RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis. Gut 2017; 66:1095-105 (NKI-AvL) 1267. Slotman BJ, Senan S.SABR Given Thoughtfully. International Journal of Radiation Oncology Biology Physics. 2017 Nov 15;99(4):766 (VUmc) 1268. Hsu C, Lee SH, Ejadi S, Even C, Cohen RB, Le Tourneau C, Mehnert JM, Algazi A, van Brummelen EMJ, Saraf S, Thanigaimani P, Cheng JD, Hansen AR.Safety and Antitumor Activity of Pembrolizumab in Patients With Programmed Death-Ligand 1-Positive Nasopharyngeal Carcinoma: Results of the KEYNOTE- 028 Study. J Clin Oncol 2017; 35:4050-6 (NKI-AvL) 1269. Ott PA, Piha-Paul SA, Munster P, Pishvaian MJ, van Brummelen EMJ, Cohen RB, Gomez-Roca C, Ejadi S, Stein M, Chan E, Simonelli M, Morosky A, Saraf S, Emancipator K, Koshiji M, Bennouna J.Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with recurrent carcinoma of the anal canal. Ann Oncol 2017; 28:1036-41 (NKI-AvL) 1270. Frenel JS, Le Tourneau C, O'Neil B, Ott PA, Piha-Paul SA, Gomez-Roca C, van Brummelen EMJ, Rugo HS, Thomas S, Saraf S, Rangwala R, Varga A.Safety and Efficacy of Pembrolizumab in Advanced, Programmed Death Ligand 1-Positive Cervical Cancer: Results From the Phase Ib KEYNOTE-028 Trial. J Clin Oncol 2017; 35:4035-41 (NKI-AvL) 1271. Wellenstein DJ, de Witt JK, Schutte HW, Honings J, van den Hoogen FJA, Marres HAM, Takes RP, van den Broek GB.Safety of flexible endoscopic biopsy of the pharynx and larynx under topical anesthesia. Eur Arch Otorhinolaryngol 2017; 274:3471-6 (NKI-AvL) 1272. Valstar MH, de Ridder M, van den Broek EC, Stuiver MM, van Dijk BA, van Velthuysen MLF, Balm AJM, Smeele LE.Salivary gland pleomorphic adenoma in the Netherlands: A nationwide observational study of primary tumor incidence, malignant transformation, recurrence, and risk factors for recurrence. Oral Oncol 2017; 66:93-9 (AMC,NKI-AvL) 1273. Sobh M, Michallet M, Dubois V, Iacobelli S, Koster L, Van Biezen A et al.Salvage use of allogeneic hematopoietic stem cell transplantation after reduced intensity conditioning from unrelated donors in multiple myeloma. A study by the plasma cell disorders subcommittee of the european group for blood and marrow transplant chronic malignancies working party. Haematologica. 2017 Jun 26;102(7):e271- e274 (VUmc) 1274. Rodella U, Negro S, Scorzeto M, Bergamin E, Jalink K, Montecucco C, Yuki N, Rigoni M.Schwann cells are activated by ATP released from neurons in an in vitro cellular model of Miller Fisher syndrome. Dis Model Mech 2017; 10:597-603 (NKI-AvL) 1275. Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell PJ, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, Enard W, Farmer A, Fugger L, Gottgens B, Hacohen N, Haniffa M, Hemberg M, Kim SK, Klenerman P, Kriegstein A, Lein E, Linnarsson S, Lundberg E, Lundeberg J, Majumder P, Marioni JC, Merad M, Mhlanga M, Nawijn M, Netea M, Nolan G,

154 - Scientific publications Pe'er D, Phillipakis A, Ponting CP, Quake SR, Reik W, Rozenblatt-Rosen O, Sanes JR, Satija R, Schumacher TN, Shalek AK, Shapiro E, Sharma P, Shin JW, Stegle O, Stratton MR, Stubbington MJT, Theis FJ, Uhlen M, van Oudenaarden A, Wagner A, Watt FM, Weissman JS, Wold BJ, Xavier RJ, Yosef N.Science Forum: The Human Cell Atlas. Elife 2017; 6:e27041 (NKI-AvL) 1276. Soo RA, Stone ECA, Cummings KM, Jett JR, Field JK, Groen HJM et al.Scientific Advances in Thoracic Oncology 2016. Journal of Thoracic Oncology. 2017 Aug 1;12(8):1183-1209(NKI-AvL, VUmc) 1277. Greuter MJE, de Klerk CM, Meijer GA, Dekker E, Coupé VMH.Screening for Colorectal Cancer With Fecal Immunochemical Testing With and Without Postpolypectomy Surveillance Colonoscopy A Cost- Effectiveness Analysis.Annals of internal medicine.2017;167(8):544-+(AMC, NKI-AvL, VUmc) 1278. Salah S, Lee JL, Rozzi A, Kitamura H, Matsumoto K, Vis DJ, Srinivas S, Morales-Barrera R, Carles J, Al Rimawi D, Lee S, Kim KH, Izumi K, Lewin J.Second-line Chemotherapy in Older Patients With Metastatic Urothelial Carcinoma: Pooled Analysis of 10 Second-line Studies. Clin Genitourin Cancer 2017; 15:e563- e571 (NKI-AvL) 1279. Avila EK, Chamberlain M, Schiff D, Reijneveld JC, Armstrong TS, Ruda R et al.Seizure control as a new metric in assessing efficacy of tumor treatment in low-grade glioma trials. Neuro-Oncology. 2017;19(1):12-21 (VUmc) 1280. Soria JC, Fulop A, Maciel C, Fischer JR, Girotto G, Lago S, Smit E, Ostoros G, Eberhardt WEE, Lishkovska P, Lovick S, Mariani G, McKeown A, Kilgour E, Smith P, Bowen K, Kohlmann A, Carlile DJ, Janne PA.SELECT-2: a Phase II, double-blind, randomised, placebo-controlled study to assess the efficacy of selumetinib plus docetaxel as a second-line treatment for patients with advanced or metastatic non- small cell lung cancer. Ann Oncol 2017; 28:3028-36 (NKI-AvL) 1281. Pajic M, Blatter S, Guyader C, Gonggrijp M, Kersbergen A, Kucukosmanoglu A, Sol W, Drost R, Jonkers J, Borst P, Rottenberg S.Selected alkylating agents can overcome drug tolerance of G0-like tumor cells and eradicate BRCA1-deficient mammary tumors in mice. Clin Cancer Res 2017; 23:7020-33 (NKI-AvL) 1282. Van Zummeren M, Kremer WW, Van Aardt MC, Breytenbach E, Richter KL, Rozendaal L et al.Selection of women at risk for cervical cancer in an HIV-infected South African population. AIDS. 2017 Sep 10;31(14):1945-1953 (VUmc) 1283. Janne PA, van den Heuvel MM, Barlesi F, Cobo M, Mazieres J, Crino L, Orlov S, Blackhall F, Wolf J, Garrido P, Poltoratskiy A, Mariani G, Ghiorghiu D, Kilgour E, Smith P, Kohlmann A, Carlile DJ, Lawrence D, Bowen K, Vansteenkiste J.Selumetinib Plus Docetaxel Compared With Docetaxel Alone and Progression-Free Survival in Patients With KRAS-Mutant Advanced Non-Small Cell Lung Cancer: The SELECT-1 Randomized Clinical Trial. JAMA 2017; 317:1844-53 (NKI-AvL) 1284. Eskes M, Balm AJM, van Alphen MJA, Smeele LE, Stavness I, van der Heijden F.sEMG-assisted inverse modelling of 3D lip movement: a feasibility study towards person-specific modelling. Sci Rep 2017; 7:17729 (14 pp) (NKI-AvL) 1285. Kommers IO, Bartley PA, Budgen B, Latham S, Beligaswatte A, Supple SG et al.Sensitive monitoring of acute promyelocytic leukemia by PML-RARA DNA Q-PCR. Leukemia and Lymphoma. 2017 Jul 3;58(7):1767-1769 (VUmc) 1286. Oei AL, Vriend LEM, van Leeuwen CM, Rodermond HM, ten Cate R, Westermann AMM, Stalpers LJA, Crezee J, Kanaar R, Kok HP, Krawczyk P, Franken NAP.Sensitizing thermochemotherapy with a PARP1- inhibitor.Oncotarget.2017;8(10):16303-16312 (AMC) 1287. Grivas N, Wit E, Pos F, de Jong J, Vegt E, Bex A, Hendricksen K, Horenblas S, KleinJan G, van Rhijn B, van der Poel H.Sentinel Lymph Node Dissection to Select Clinically Node-negative Prostate Cancer Patients for Pelvic Radiation Therapy: Effect on Biochemical Recurrence and Systemic Progression. Int J Radiat Oncol Biol Phys 2017; 97:347-54 (NKI-AvL) 1288. van der Poel HG, Meershoek P, Grivas N, KleinJan G, van Leeuwen FWB, Horenblas S.Sentinel node biopsy and lymphatic mapping in penile and prostate cancer / Wachterlymphknotenresektion und Lymphknotenmapping bei Penis- und Prostatakarzinom. Urologe A 2017; 56:13-7 (NKI-AvL) 1289. van der Poel HG, Wit EM, Acar C, van den Berg NS, van Leeuwen FWB, Valdes Olmos RA, Winter A, Wawroschek F, Liedberg F, MacLennan S, Lam T.Sentinel node biopsy for prostate cancer: report from a consensus panel meeting. BJU Int 2017; 120:204-11 (NKI-AvL) 1290. Madu MF, Wouters MW, van Akkooi AC.Sentinel node biopsy in melanoma: Current controversies addressed. Eur J Surg Oncol 2017; 43:517-33 (NKI-AvL) 1291. Valdes Olmos RA, Vidal-Sicart S.Sentinel node in lung cancer - Ganglio centinela en el cancer pulmonar. Med Clin (Barc) 2017; 148:260-1 [Editorial] (NKI-AvL) 1292. Wit EM, Acar C, Grivas N, Yuan C, Horenblas S, Liedberg F, Valdes Olmos RA, van Leeuwen FWB, van den Berg NS, Winter A, Wawroschek F, Hruby S, Janetschek G, Vidal-Sicart S, MacLennan S, Lam TB, van der Poel HG.Sentinel Node Procedure in Prostate Cancer: A Systematic Review to Assess Diagnostic Accuracy. Eur Urol 2017; 71:595-605 (NKI-AvL) 1293. Amant F, Trum H.Sentinel-lymph-node mapping in endometrial cancer: routine practice?.Lancet Oncol 2017; 18:281-2 [Comment] (NKI-AvL) 1294. 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Henselmans I, van Laarhoven HWM, van der Vloodt J, de Haes JCJM, Smets EMA.Shared decision making about palliative chemotherapy: A qualitative observation of talk about patients' preferences.Palliative medicine.2017;31(7):625-633 (AMC) 1300. Rood JAJ, Nauta IH, Witte BI, Stam F, van Zuuren FJ, Manenschijn A et al.Shared decision-making and providing information among newly diagnosed patients with hematological malignancies and their informal caregivers: Not "one-size-fits-all". Psycho-Oncology. 2017 Dec (VUmc) 1301. Meerveld-Eggink A, Rozeman EA, Lalezari F, van Thienen JV, Haanen JBAG, Blank CU.Short-term CTLA-4 blockade directly followed by PD-1 blockade in advanced melanoma patients - a single center experience. Ann Oncol 2017; 28:862-7 (NKI-AvL) 1302. 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156 - Scientific publications 1318. Fontein DBY, Charehbili A, Nortier JWR, Putter H, Kranenbarg EM, Kroep JR, Linn SC, van de Velde CJH.Specific adverse events are associated with response to exemestane therapy in postmenopausal breast cancer patients: Results from the TEAMIIA study (BOOG2006-04). Eur J Surg Oncol 2017; 43:619- 24 (NKI-AvL) 1319. Canales TM, de Leeuw DC, Vermue E, Ossenkoppele GJ, Smit L.Specific depletion of leukemic stem cells: Can microRNAs make the difference? Cancers.. 2017 Jul 1;9(7):74 (VUmc) 1320. Groot M, Ebenau AF, Koning H, Visser A, Leget C, van Laarhoven HWM, van Leeuwen Ré, Ruben R, Wulp M, Garssen B.Spiritual care by nurses in curative cancer care: Protocol for a national, multicentre, mixed method study.Journal of advanced nursing.2017;73(9):2201-2207 (AMC) 1321. 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Thomas G, Tuk B, Song JY, Truong H, Gerritsen HC, de Gruijl FR, Sterenborg HJ.Studying skin tumourigenesis and progression in immunocompetent hairless SKH1-hr mice using chronic 7,12- dimethylbenz(a)anthracene topical applications to develop a useful experimental skin cancer model. Lab Anim 2017; 51:24-35 (AMC,NKI-AvL) 1346. van Zon M, de Punder K, van der Sar A, Brosch R, Pando RH, Grootemaat A, Tigchelaar-Gutter W, van der Wel N.Subcellular localization of M tuberculosis in vivo and effect of the adaptive immunity. Ultrastruct Pathol 2017; 41:133 [?(NKI-AvL) 1347. 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Thompson JE, Egger S, Böhm M, Siriwardana AR, Haynes A-M, Matthews J, Scheltema MJV, Stricker PD.Superior Biochemical Recurrence and Long-term Quality-of-life Outcomes Are Achievable with Robotic Radical Prostatectomy After a Long Learning Curve-Updated Analysis of a Prospective Single- surgeon Cohort of 2206 Consecutive Cases.European urology.2017 (AMC) 1350. Janssen NNY, Ter Beek LC, Loo CE, Winter-Warnars G, Lange CA, van Loveren M, Alderliesten T, Sonke JJ, Nijkamp J.Supine Breast MRI Using Respiratory Triggering. Acad Radiol 2017; 24:818-925 (NKI-AvL) 1351. Timmers L, Boons CCLM, Verbrugghe M, van den Bemt BJF, Van Hecke A, Hugtenburg JG.Supporting adherence to oral anticancer agents: Clinical practice and clues to improve care provided by physicians, nurse practitioners, nurses and pharmacists. BMC Cancer. 2017 Feb 10;17(1):122 (VUmc) 1352. 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Gool EL, Stojanovic I, Schasfoort RBM, Sturk A, van Leeuwen AGJM, Nieuwland R, Terstappen LWMM, Coumans FAW.Surface Plasmon Resonance is an Analytically Sensitive Method for Antigen Profiling of Extracellular Vesicles.Clinical chemistry.2017;63(10):1633-1641 (AMC)

158 - Scientific publications 1357. Cuesta MA, van der Wielen N, Weijs TJ, Bleys RLAW, Gisbertz SS, van Duijvendijk P et al.Surgical anatomy of the supracarinal esophagus based on a minimally invasive approach: vascular and nervous anatomy and technical steps to resection and lymphadenectomy. Surgical Endoscopy and Other Interventional Techniques. 2017 Apr 1;31(4):1863-1870 (VUmc) 1358. Dickhoff C, Dahele M, Hashemi SM, Senan S, Smit EF, Hartemink KJ et al.Surgical Treatment of Complications After High-Dose Chemoradiotherapy for Lung Cancer. Annals of Thoracic Surgery. 2017 Aug 1;104(2):436-442(NKI-AvL, VUmc) 1359. Grimm LJ, Ryser MD, Partridge AH, Thompson AM, Thomas JS, Wesseling J, Hwang ES.Surgical Upstaging Rates for Vacuum Assisted Biopsy Proven DCIS: Implications for Active Surveillance Trials. Ann Surg Oncol 2017; 24:3534-40 (NKI-AvL) 1360. 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Scientific publications - 163 HWM, Yang GM.The international phase 4 validation study of the EORTC QLQ-SWB32: A stand-alone measure of spiritual well-being for people receiving palliative care for cancer.European journal of cancer care.2017;26(6):e12697 (AMC) 1459. van der Noordaa MEM, Vrancken Peeters MTFD, Rutgers EJT.The intraoperative assessment of sentinel nodes - Standards and controversies. Breast 2017; 34 Suppl 1:S64-S69 (NKI-AvL) 1460. van Es N, Franke VF, Middeldorp S, Wilmink JW, Buller HR.The Khorana score for the prediction of venous thromboembolism in patients with pancreatic cancer.Thrombosis research.2017;150():30-32 (AMC) 1461. Younes A, Ansell S, Fowler N, Wilson W, de Vos S, Seymour J, Advani R, Forero A, Morschhauser F, Kersten MJ, Tobinai K, Zinzani PL, Zucca E, Abramson J, Vose J.The landscape of new drugs in lymphoma.Nature reviews. Clinical oncology.2017;14(6):335-346 (AMC) 1462. Smith HG, Tzanis D, Messiou C, Benson C, van der Hage JA, Fiore M, Bonvalot S, Hayes AJ.The management of soft tissue tumours of the abdominal wall. Eur J Surg Oncol 2017; 43:1647-55 (NKI-AvL) 1463. de Boer MC, Wörner EA, Verlaan D, van Leeuwen PAM.The Mechanisms and Effects of Physical Activity on Breast Cancer. Clinical Breast Cancer. 2017 Jul 1;17(4):272-278 (VUmc) 1464. Elshof LE, Schaapveld M, Rutgers EJ, Schmidt MK, de Munck L, van Leeuwen FE, Wesseling J.The method of detection of ductal carcinoma in situ has no therapeutic implications: results of a population-based cohort study. Breast Cancer Res 2017; 19:26 (NKI-AvL) 1465. Han R, Slobodin B, Agami R.The methylated way to translation. Oncotarget 2017; 8:93313-4 [Editorial] (NKI-AvL) 1466. Balikov DA, Brady SK, Ko UH, Shin JH, de Pereda JM, Sonnenberg A, Sung HJ, Lang MJ.The nesprin- cytoskeleton interface probed directly on single nuclei is a mechanically rich system. Nucleus 2017; 8:534-47 (NKI-AvL) 1467. Rakhorst HA, Mureau MAM, Cooter RD, McNeil J, van Hooff M, van der Hulst R, Hommes J, Hoornweg M, Moojen-Zaal L, Liem P, Mathijssen IMJ.The new opt-out Dutch National Breast Implant Registry - Lessons learnt from the road to implementation. J Plast Reconstr Aesthet Surg 2017; 70:1354-60 (NKI-AvL) 1468. Bijnsdorp IV, van Royen ME, Verhaegh GW, Martens-Uzunova ES.The Non-Coding Transcriptome of Prostate Cancer: Implications for Clinical Practice. Molecular Diagnosis and Therapy. 2017 Aug 1;21(4):385-400 (VUmc) 1469. Bronzwaer MES, Musters GD, Barendse RM, Koens L, de Graaf EJR, Doornebosch PG, Schwartz MP, Consten ECJ, Schoon EJ, de Hingh IHJT, Tanis PJ, Dekker E, Fockens P.The occurrence and characteristics of endoscopically unexpected malignant degeneration in large rectal adenomas.Gastrointestinal endoscopy.2017 (AMC) 1470. Ramovs V, Te Molder L, Sonnenberg A.The opposing roles of laminin-binding integrins in cancer. Matrix Biol 2017; 57-58:213-43 (NKI-AvL) 1471. van der Linden M, Meeuwis K, van Hees C, van Dorst E, Bulten J, Bosse T, IntHout J, Boll D, Slangen B, van Seters M, van Beurden M, van Poelgeest M, de Hullu J.The Paget Trial: A Multicenter, Observational Cohort Intervention Study for the Clinical Efficacy, Safety, and Immunological Response of Topical 5% Imiquimod Cream for Vulvar Paget Disease. JMIR Res Protoc 2017; 6:e178 (NKI-AvL) 1472. Eckelman WC, Windhorst AD, O'Hara C.The past, present, and the promise of the future of nuclear medicine and biology. Nuclear Medicine and Biology. 2017 Dec 1;55:47-48 (VUmc) 1473. Niemeijer ND, Rijken JA, Eijkelenkamp K, Van Der Horst-Schrivers ANA, Kerstens MN, Tops CMJ et al.The phenotype of SDHB germline mutation carriers: A nationwide study. European Journal of Endocrinology. 2017 Aug 1;177(2):115-125 (VUmc) 1474. Manegold C, Dingemans AMC, Gray JE, Nakagawa K, Nicolson M, Peters S et al.The Potential of Combined Immunotherapy and Antiangiogenesis for the Synergistic Treatment of Advanced NSCLC. Journal of Thoracic Oncology. 2017 Feb 1;12(2):194-207(NKI-AvL, VUmc) 1475. Da Silva CG, Peters GJ, Ossendorp F, Cruz LJ.The potential of multi-compound nanoparticles to bypass drug resistance in cancer. Cancer Chemotherapy and Pharmacology. 2017 Nov 1;80(5):881-894 (VUmc) 1476. van der Kaaij RT, Snaebjornsson P, Voncken FE, van Dieren JM, Jansen EP, Sikorska K, Cats A, van Sandick JW.The prognostic and potentially predictive value of the Lauren classification in oesophageal adenocarcinoma. Eur J Cancer 2017; 76:27-35 (NKI-AvL) 1477. Roeke T, Sobral-Leite M, Dekker TJA, Wesseling J, Smit VTHB, Tollenaar RAEM, Schmidt MK, Mesker WE.The prognostic value of the tumour-stroma ratio in primary operable invasive cancer of the breast: a validation study. Breast Cancer Res Treat 2017; 166:435-45 (NKI-AvL) 1478. Postema AW, Scheltema MJV, Mannaerts CK, van Sloun RJG, Idzenga T, Mischi M, Engelbrecht MRE, Delarosette JJMCH, Wijkstra H.The prostate cancer detection rates of CEUS-targeted versus MRI- targeted versus systematic TRUS-guided biopsies in biopsy-naïve men: a prospective, comparative clinical trial using the same patients.BMC urology.2017;17(1):27 (AMC) 1479. Huijbers EJM, Griffioen AW.The revival of cancer vaccines - The eminent need to activate humoral immunity. Human Vaccines & Immunotherapeutics. 2017 May 4;13(5):1112-1114 (VUmc) 1480. Veluchamy JP, Kok N, van der Vliet HJ, Verheul HMW, de Gruijl TD, Spanholtz J.The rise of allogeneic Natural killer cells as a platform for cancer immunotherapy: Recent innovations and future developments. Frontiers in Immunology. 2017 May 31;8(MAY):631 (VUmc) 1481. 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164 - Scientific publications 1482. Ottenhof SR, Vegt E.The role of PET/CT imaging in penile cancer. Transl Androl Urol 2017; 6:833-8 (NKI- AvL) 1483. Wilson MJ, Dekker JWT, Harlaar JJ, Jeekel J, Schipperus M, Zwaginga JJ.The role of preoperative iron deficiency in colorectal cancer patients: prevalence and treatment. International Journal of Colorectal Disease. 2017 Nov 1;32(11):1617-1624 (VUmc) 1484. Plat VD, Bootsma BT, van der Wielen N, Straatman J, Schoonmade LJ, van der Peet DL et al.The role of tissue adhesives in esophageal surgery, a systematic review of literature. International Journal of Surgery. 2017 Apr 1;40:163-168 (VUmc) 1485. van Keimpema M, Gruneberg LJ, Schilder-Tol EJ, Oud ME, Beuling EA, Hensbergen PJ, de Jong J, Pals ST, Spaargaren M.The small FOXP1 isoform predominantly expressed in activated B cell-like diffuse large B-cell lymphoma and full-length FOXP1 exert similar oncogenic and transcriptional activity in human B cells. Haematologica 2017; 102:573-83 (AMC,NKI-AvL) 1486. Tosco L, Laenen A, Briganti A, Gontero P, Karnes RJ, Albersen M, Bastian PJ, Chlosta P, Claessens F, Chun FK, Everaerts W, Gratzke C, Graefen M, Kneitz B, Marchioro G, Salas RS, Tombal B, van den Broeck T, Moris L, Battaglia A, van der Poel H, Walz J, Bossi A, de Meerleer G, Haustermans K, van Poppel H, Spahn M, Joniau S.The survival impact of neoadjuvant hormonal therapy before radical prostatectomy for treatment of high-risk prostate cancer. Prostate Cancer Prostatic Dis 2017; 20:407-12 (NKI-AvL) 1487. Habraken SJM, Sharfo AWM, Buijsen J, Verbakel WFAR, Haasbeek CJA, Öllers MC, Westerveld GH, van Wieringen N, Reerink O, Seravalli E, Braam PèM, Wendling M, Lacornerie T, Mirabel X, Weytjens R, Depuydt L, Tanadini-Lang S, Riesterer O, Haustermans K, Depuydt T, Dwarkasing RS, Willemssen FçEJA, Heijmen BJM, Méndez Romero A.The TRENDY multi-center randomized trial on hepatocellular carcinoma - Trial QA including automated treatment planning and benchmark-case results.Radiotherapy and oncology.2017;125(3):507-513(AMC, VUmc) 1488. Mans LA, Querol Cano L, van Pelt J, Giardoglou P, Keune WJ, Haramis AG.The tumor suppressor LKB1 regulates starvation-induced autophagy under systemic metabolic stress. Sci Rep 2017; 7:7327 (NKI-AvL) 1489. Thunnissen E, Borczuk AC, Flieder DB, Witte B, Beasley MB, Chung JH et al.The Use of Immunohistochemistry Improves the Diagnosis of Small Cell Lung Cancer and Its Differential Diagnosis. Journal of Thoracic Oncology. 2017 Feb 1;12(2):334-346 (VUmc) 1490. Basta YL, Bolle S, Fockens P, Tytgat KMAJ.The Value of Multidisciplinary Team Meetings for Patients with Gastrointestinal Malignancies: A Systematic Review.Annals of surgical oncology.2017;24(9):2669- 2678 (AMC) 1491. Northcott PA, Buchhalter I, Morrissy AS, Hovestadt V, Weischenfeldt J, Ehrenberger T, Gröbner S, Segura-Wang M, Zichner T, Rudneva VA, Warnatz H-Jö, Sidiropoulos N, Phillips AH, Schumacher S, Kleinheinz K, Waszak SM, Erkek S, Jones DTW, Worst BC, Kool M, Zapatka M, Jäger N, Chavez L, Hutter B, Bieg M, Paramasivam N, Heinold M, Gu Z, Ishaque N, Jäger-Schmidt C, Imbusch CD, Jugold A, Hübschmann D, Risch T, Amstislavskiy V, Gonzalez FGR, Weber UD, Wolf S, Robinson GW, Zhou X, Wu G, Finkelstein D, Liu Y, Cavalli FMG, Luu B, Ramaswamy V, Wu X, Koster JJB, Ryzhova M, Cho Y-J, Pomeroy SL, Herold-Mende C, Schuhmann M, Ebinger M, Liau LM, Mora J, McLendon RE, Jabado N, Kumabe T, Chuah E, Ma Y, Moore RA, Mungall AJ, Mungall KL, Thiessen N, Tse K, Wong T, Jones SJM, Witt O, Milde T, von Deimling A, Capper D, Korshunov A, Yaspo M-L, Kriwacki R, Gajjar A, Zhang J, Beroukhim R, Fraenkel E, Korbel JO, Brors B, Schlesner M, Eils R, Marra MA, Pfister SM, Taylor MD, Lichter P.The whole-genome landscape of medulloblastoma subtypes.Nature.2017;547(7663):311-317 (AMC) 1492. De Langen AJ, Smit EF.Therapeutic approach to treating patients with BRAF-mutant lung cancer: Latest evidence and clinical implications. Therapeutic Advances in Medical Oncology. 2017 Jan 1;9(1):46-58 (VUmc) 1493. Li B, Ni Chonghaile T, Fan Y, Madden S, Klinger R, O'Connor AE, Walsh L, O'Hurley G, Mallya Udupi G, Joseph J, Tarrant F, Conroy E, Gaber A, Chin SF, Bardwell HA, Provenzano E, Crown J, Dubois T, Linn SC, Jirstrom K, Caldas C, O'Connor D, Gallagher WM.Therapeutic Rationale to Target Highly Expressed CDK7 Conferring Poor Outcomes in Triple-Negative Breast Cancer. Cancer Res 2017; 77:3834-45 (NKI- AvL) 1494. Löwenberg B, Pabst T, Maertens J, Van Norden Y, Biemond BJ, Schouten HC et al.Therapeutic value of clofarabine in younger and middle-aged (18-65 years) adults with newly diagnosed AML. Blood. 2017 Mar 23;129(12):1636-1645(AMC, VUmc) 1495. van Egmond MP, Duijts SFA, van Muijen P, van der Beek AJ, Anema JR.Therapeutic Work as a Facilitator for Return to Paid Work in Cancer Survivors. Journal of Occupational Rehabilitation. 2017 Mar 1;27(1):148-155(NKI-AvL, VUmc) 1496. Bakker A, Kolff WW, Holman R, van Leeuwen CM, Korshuize-van Straten L, de Kroon-Oldenhof R, Rasch CRN, van Tienhoven G, Crezee J.Thermal Skin Damage During Reirradiation and Hyperthermia Is Time- Temperature Dependent.International journal of radiation oncology, biology, physics.2017;98(2):392-399 (AMC) 1497. Wildeboer RR, Schalk SG, Demi L, Wijkstra H, Mischi M.Three-dimensional histopathological reconstruction as a reliable ground truth for prostate cancer studies.Biomedical physics and engineering Express.2017;3(3):035014 (AMC) 1498. Schadendorf D, Long GV, Stroiakovski D, Karaszewska B, Hauschild A, Levchenko E, Chiarion-Sileni V, Schachter J, Garbe C, Dutriaux C, Gogas H, Mandala M, Haanen JBAG, Lebbe C, Mackiewicz A, Rutkowski P, Grob JJ, Nathan P, Ribas A, Davies MA, Zhang Y, Kaper M, Mookerjee B, Legos JJ, Flaherty KT, Robert

Scientific publications - 165 C.Three-year pooled analysis of factors associated with clinical outcomes across dabrafenib and trametinib combination therapy phase 3 randomised trials. Eur J Cancer 2017; 82:45-55 (NKI-AvL) 1499. Slotman BJ.Time to reconsider prophylactic cranial irradiation in extensive-stage small-cell lung cancer? Lancet Oncology.. 2017 May;18(5):566-567 (VUmc) 1500. Middelburg JG, Mast ME, de Kroon M, Jobsen JJ, Rozema T, Maas H, Baartman EA, Geijsen ED, van der Leest AH, van den Bongard DéJ, van Loon J, Budiharto T, Coebergh JW, Aarts MJ, Struikmans H.Timed Get Up and Go Test and Geriatric 8 Scores and the Association With (Chemo-)Radiation Therapy Noncompliance and Acute Toxicity in Elderly Cancer Patients.International journal of radiation oncology, biology, physics.2017;98(4):843-849 (AMC) 1501. de Ruiter MA, Grootenhuis MA, van Mourik R, Maurice-Stam H, Breteler MHM, Gidding C, Beek LR, Granzen B, van Vuurden DG, Schouten-van Meeteren AYN, Oosterlaan J.Timed performance weaknesses on computerized tasks in pediatric brain tumor survivors: A comparison with sibling controls.Child neuropsychology.2017;23(2):208-227 (AMC) 1502. Vogel JA, van Veldhuisen E, Agnass P, Crezee J, Dijk F, Verheij J, van Gulik TM, Meijerink MR, Vroomen LG, van Lienden KPP, Besselink MGH.Time-Dependent Impact of Irreversible Electroporation on Pancreas, Liver, Blood Vessels and Nerves: A Systematic Review of Experimental Studies (vol 11, e0166987, 2016).PLoS ONE.2017;12(3):e0174018 (AMC) 1503. de Kruif MD, Gerritsen MG, van Haren EH, Bel EHD, Jonkers RE.Timing of broncho-alveolar lavage for galactomannan testing in hematological oncology patients.clinical respiratory journal.2017;11(4):534- 536 (AMC) 1504. Oude Ophuis CM, van Akkooi AC, Rutkowski P, Powell WE, Robert C, Testori A, van Leeuwen BL, Siegel P, Eggermont AM, Verhoef C, Grunhagen DJ.Timing of completion lymphadenectomy after positive sentinel node biopsy in patients with melanoma. Br J Surg 2017; 104:726-33 (NKI-AvL) 1505. van Eden WJ, Kok NF, Jozwiak K, Lahaye ML, Beets GL, van Leerdam ME, Boot H, Aalbers AG.Timing of Systemic Chemotherapy in Patients With Colorectal Peritoneal Carcinomatosis Treated With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Dis Colon Rectum 2017; 60:477- 87 (NKI-AvL) 1506. Patty NJS, Van Dijk HM, Wallenburg I, Bal R, Helmerhorst TJM, Van Exel J et al.To vaccinate or not to vaccinate? Perspectives on HPV vaccination among girls, boys, and parents in the Netherlands: A Q- methodological study. BMC Public Health. 2017 Nov 7;17(1):872 (VUmc) 1507. Kwakman JJ, Baars A, Boot H, Pruijt JF, Winther SB, Pfeiffer P, Punt CJ.Tolerability of the oral fluoropyrimidine S-1 after hand-foot syndrome-related discontinuation of capecitabine in western cancer patients. Acta Oncol 2017; 56:1023-6 (AMC,NKI-AvL) 1508. Carey CD, Gusenleitner D, Lipschitz M, Roemer MGM, Stack EC, Gjini E et al.Topological analysis reveals a PD-L1-associated microenvironmental niche for Reed-Sternberg cells in Hodgkin lymphoma. Blood. 2017 Nov 30;130(22):2420-2430 (VUmc) 1509. van der Vaart B, Fischbock J, Mieck C, Pichler P, Mechtler K, Medema RH, Westermann S.TORC1 signaling exerts spatial control over microtubule dynamics by promoting nuclear export of Stu2. J Cell Biol 2017; 216:3471-84 (NKI-AvL) 1510. Hoedjes M, van Stralen MM, Joe ST, Rookus M, van Leeuwen F, Michie S, Seidell JC, Kampman E.Toward the optimal strategy for sustained weight loss in overweight cancer survivors: a systematic review of the literature. J Cancer Surviv 2017; 11:360-85 (NKI-AvL) 1511. Vis DJ, Lewin J, Liao RG, Mao M, Andre F, Ward RL, Calvo F, Teh BT, Camargo AA, Knoppers BM, Sawyers CL, Wessels LFA, Lawler M, Siu LL, Voest E.Towards a global cancer knowledge network: dissecting the current international cancer genomic sequencing landscape. Ann Oncol 2017; 28:1145-51 (NKI-AvL) 1512. Suurmond JL, Lieveld A, van de Wetering M, Schouten-van Meeteren AYN.Towards culturally competent paediatric oncology care. A qualitative study from the perspective of care providers.European journal of cancer care.2017;26(6):e12680 (AMC) 1513. Luttje MP, van Buuren LD, Luijten PR, van Vulpen M, van der Heide UA, Klomp DWJ.Towards intrinsic R2* imaging in the prostate at 3 and 7tesla. Magn Reson Imaging 2017; 42:16-21 (NKI-AvL) 1514. Fagerholm R, Khan S, Schmidt MK, Garcia-Closas M, Heikkila P, Saarela J, Beesley J, Jamshidi M, Aittomaki K, Liu J, Ali HR, Andrulis IL, Beckmann MW, Behrens S, Blows FM, Brenner H, Chang-Claude J, Couch FJ, Czene K, Fasching PA, Figueroa J, Floris G, Glendon G, Guo Q, Hall P, Hallberg E, Hamann U, Holleczek B, Hooning MJ, Hopper JL, Jager A, Kabisch M, Keeman R, Kosma VM, Lambrechts D, Lindblom A, Mannermaa A, Margolin S, Provenzano E, Shah M, Southey MC, Dennis J, Lush M, Michailidou K, Wang Q, Bolla MK, Dunning AM, Easton DF, Pharoah PD, Chenevix-Trench G, Blomqvist C, Nevanlinna H.TP53- based interaction analysis identifies cis-eQTL variants for TP53BP2, FBXO28, and FAM53A that associate with survival and treatment outcome in breast cancer. Oncotarget 2017; 8:18381-98 (NKI-AvL) 1515. Koedam TWA, van Ramshorst GH, Deijen CL, Elfrink AKE, Meijerink WJHJ, Bonjer HJ et al.Transanal total mesorectal excision (TaTME) for rectal cancer: effects on patient-reported quality of life and functional outcome. Techniques in Coloproctology. 2017 Jan 1;21(1):25-33 (VUmc) 1516. Penna M, Hompes R, Arnold S, Wynn G, Austin R, Warusavitarne J et al.Transanal Total Mesorectal Excision: International Registry Results of the First 720 Cases. Annals of Surgery. 2017;266(1):111-117 (VUmc) 1517. Slobodin B, Han R, Calderone V, Vrielink JA, Loayza-Puch F, Elkon R, Agami R.Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation. Cell 2017; 169:326-37 (NKI-AvL)

166 - Scientific publications 1518. Nagaraja S, Vitanza NA, Woo PJ, Taylor KR, Liu F, Zhang L et al.Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma. Cancer Cell. 2017 May 8;31(5):635-652 (VUmc) 1519. van Leeuwen-Kerkhoff N, Lundberg K, Westers TM, Kordasti S, Bontkes HJ, de Gruijl TD et al.Transcriptional profiling reveals functional dichotomy between human slan+ non-classical monocytes and myeloid dendritic cells. Journal of Leukocyte Biology. 2017 Oct 1;102(4):1055-1068 (VUmc) 1520. Dierks J, Gaspersz MP, Belkouz A, van Vugt JLA, Coelen RJS, de Groot JWB, ten Tije AJ, Meijer WG, Pruijt JFM, van Voorthuizen T, van Spronsen DJ, Rentinck M, ten Oever D, Smit JM, Otten HM, van Gulik TM, Wilmink JW, Groot Koerkamp B, Klümpen H.Translating the ABC-02 trial into daily practice: outcome of palliative treatment in patients with unresectable biliary tract cancer treated with gemcitabine and cisplatin.Acta oncologica (Stockholm, Sweden).2017;():1-6 (AMC) 1521. van Ramshorst MS, van Werkhoven E, Mandjes IAM, Schot M, Wesseling J, Vrancken Peeters MTFD, Meerum Terwogt JM, Bos MEM, Oosterkamp HM, Rodenhuis S, Linn SC, Sonke GS.Trastuzumab in combination with weekly paclitaxel and carboplatin as neo-adjuvant treatment for HER2-positive breast cancer: The TRAIN-study. Eur J Cancer 2017; 74:47-54 (NKI-AvL) 1522. Hoffmann VS, Baccarani M, Hasford J, Castagnetti F, Di Raimondo F, Casado LF et al.Treatment and outcome of 2904 CML patients from the EUTOS population-based registry. Leukemia. 2017 Mar;31(3):593-601 (VUmc) 1523. Kraal K, Blom TJ, van Noesel M, Kremer LCM, Caron HN, Tytgat GAM, van der Pal HJH.Treatment and outcome of neuroblastoma with intraspinal extension: A systematic review.Pediatric blood & cancer.2017;64(8):e26451 (AMC) 1524. Dinmohamed AG, Issa DE, van der Poel MWM, Schouten HC, Lugtenburg PJ, Chamuleau MED et al.Treatment and relative survival in very elderly patients with DLBCL in The Netherlands: a population- based study, 1989 to 2015. Blood. 2017 Sep 26;1(21):1839-1841 (VUmc) 1525. Reuling EMBP, Dickhoff C, Daniels JMA.Treatment of Bronchial Carcinoid Tumors: Is Surgery Really Necessary? Journal of Thoracic Oncology.. 2017 May 1;12(5):e57-e58 (VUmc) 1526. van der Kaaij RT, Braam HJ, Boot H, Los M, Cats A, Grootscholten C, Schellens JHM, Aalbers AGJ, Huitema ADR, Knibbe CA, Boerma D, Wiezer MJ, van Ramshorst B, van Sandick JW.Treatment of Peritoneal Dissemination in Stomach Cancer Patients With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC): Rationale and Design of the PERISCOPE Study. JMIR Res Protoc 2017; 6:e136 (NKI-AvL) 1527. Doorduijn J, van Imhoff G, van der Holt B, Schouten H, Schaafsma M, MacKenzie M, Baars J, Kersten M, Lugtenburg P, van den Bent M, Enting R, Spoelstra F, Poortmans P, Bromberg J.Treatment of secondary central nervous system lymphoma with intrathecal rituximab, high-dose methotrexate, and R-DHAP followed by autologous stem cell transplantation: results of the HOVON 80 phase 2 study. Hematol Oncol 2017; 35:497-503 (AMC,NKI-AvL) 1528. Geelen IGP, Thielen N, Janssen JJWM, Hoogendoorn M, Roosma TJA, Willemsen SP et al.Treatment outcome in a population-based, ‘real-world’ cohort of patients with chronic myeloid leukemia. Haematologica. 2017 Oct 27;102(11):1842-1849 (VUmc) 1529. van Linde ME, Brahm CG, de Witt Hamer PC, Reijneveld JC, Bruynzeel AME, Vandertop WP et al.Treatment outcome of patients with recurrent glioblastoma multiforme: a retrospective multicenter analysis. Journal of Neuro-Oncology. 2017 Oct 1;135(1):183-192(AMC, VUmc) 1530. van der Linden N, Bongers ML, Coupé VMH, Smit EF, Groen HJM, Welling A et al.Treatment Patterns and Differences in Survival of Non-Small Cell Lung Cancer Patients Between Academic and Non-Academic Hospitals in the Netherlands. Clinical Lung Cancer. 2017 Sep 1;18(5):e341-e347 (VUmc) 1531. Butter R, Lagarde SM, van Oijen MGH, Anderegg MCJ, Gisbertz SS, Meijer SL, Hulshof MCCM, Bergman JJGHM, van Berge Henegouwen MI, van Laarhoven HWM.Treatment strategies in recurrent esophageal or junctional cancer.Diseases of the esophagus.2017;30(9):1-9 (AMC) 1532. Walraven I, Damhuis RA, Ten Berge MG, Rosskamp M, van Eycken L, De Ruysscher D, Belderbos JSA.Treatment Variation of Sequential versus Concurrent Chemoradiotherapy in Stage III Non-Small Cell Lung Cancer Patients in the Netherlands and Belgium. Clin Oncol (R Coll Radiol) 2017; 29:e177-e185 (NKI-AvL) 1533. Chen H, Senan S, Nossent EJ, Boldt RG, Warner A, Palma DA et al.Treatment-Related Toxicity in Patients With Early-Stage Non-Small Cell Lung Cancer and Coexisting Interstitial Lung Disease: A Systematic Review. International journal of radiation oncology, biology, physics. 2017 Jul 1;98(3):622- 631 (VUmc) 1534. Meulepas JM, Smets AM, Nievelstein RA, Gradowska P, Verbeke J, Holscher HC, Rutten MJ, Kieft M, Ronckers CM, Hauptmann M.Trends and patterns of computed tomography scan use among children in The Netherlands: 1990-2012. Eur Radiol 2017; 27:2426-33 (NKI-AvL) 1535. Bronsveld HK, Peeters PJ, de Groot MC, de Boer A, Schmidt MK, De Bruin ML.Trends in breast cancer incidence among women with type-2 diabetes in British general practice. Prim Care Diabetes 2017; 11:373-82 (NKI-AvL) 1536. Miles DC, de Vries NA, Gisler S, Lieftink C, Akhtar W, Gogola E, Pawlitzky I, Hulsman D, Tanger E, Koppens M, Beijersbergen RL, van Lohuizen M.TRIM28 is an Epigenetic Barrier to Induced Pluripotent Stem Cell Reprogramming. Stem Cells 2017; 35:147-57 (NKI-AvL) 1537. Mir SE, Smits M, Biesmans D, Julsing M, Bugiani M, Aronica E et al.Trimethylation of H3K27 during human cerebellar development in relation to medulloblastoma. Oncotarget. 2017;8(45):78978-78988 (VUmc)

Scientific publications - 167 1538. Klaassen ILM, Lauw MN, van de Wetering MD, Biemond BJ, Middeldorp S, Abbink FCH et al.TropicALL study: Thromboprophylaxis in Children treated for Acute Lymphoblastic Leukemia with Low-molecular- weight heparin: a multicenter randomized controlled trial. BMC Pediatrics. 2017 May 10;17(1):122(AMC, VUmc) 1539. Wielders E, Delzenne-Goette E, Dekker R, van der Valk M, Te Riele H.Truncation of the MSH2 C-terminal 60 amino acids disrupts effective DNA mismatch repair and is causative for Lynch syndrome. Fam Cancer 2017; 16:221-9 (NKI-AvL) 1540. Tame MA, Manjon AG, Belokhvostova D, Raaijmakers JA, Medema RH.TUBB3 overexpression has a negligible effect on the sensitivity to taxol in cultured cell lines. Oncotarget 2017; 8:71536-47 (NKI-AvL) 1541. Weeber F, Ooft SN, Dijkstra KK, Voest EE.Tumor Organoids as a Pre-clinical Cancer Model for Drug Discovery. Cell Chem Biol 2017; 24:1092-100 (NKI-AvL) 1542. Yalcin Z, Selenz C, Jacobs JJL.Ubiquitination and SUMOylation in Telomere Maintenance and Dysfunction. Front Genet 2017; 8:67 (15 pp) (NKI-AvL) 1543. van Sloun RJG, Demi L, Postema AW, Delarosette JJMCH, Wijkstra H, Mischi M.Ultrasound-contrast-agent dispersion and velocity imaging for prostate cancer localization.Medical image analysis.2017;35():610- 619 (AMC) 1544. Hiruma Y, Koch A, Hazraty N, Tsakou F, Medema RH, Joosten RP, Perrakis A.Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures. J Biol Chem 2017; 292:14496- 504 (NKI-AvL) 1545. Rottenberg Y, Jacobs JM, Ratzon NZ, Grinshpun A, Cohen M, Uziely B, de Boer AGEM.Unemployment risk 2 years and 4 years following gastric cancer diagnosis: a population-based study.Journal of cancer survivorship.2017;11(1):119-125 (AMC) 1546. van den Bosch S, Dijkema T, Kunze-Busch MC, Terhaard CHJ, Raaijmakers CPJ, Doornaert PAH et al.Uniform FDG-PET guided GRAdient Dose prEscription to reduce late Radiation Toxicity (UPGRADE-RT): Study protocol for a randomized clinical trial with dose reduction to the elective neck in head and neck squamous cell carcinoma. BMC Cancer. 2017 Mar 21;17(1):208 (VUmc) 1547. de Ridder M, Klop M, Hamming-Vrieze O, de Boer JP, Jasperse B, Smit L, Vogel W, van den Brekel M, Al Mamgani A.Unknown primary head and neck squamous cell carcinoma in the era of fluorodeoxyglucose- positron emission tomography/CT and intensity-modulated radiotherapy. Head Neck 2017; 39:1382-91 (AMC,NKI-AvL) 1548. Vogelaar IP, Van Der Post RS, Van Krieken JHJM, Spruijt L, Van Zelst-Stams WAG, Kets CM et al.Unraveling genetic predisposition to familial or early onset gastric cancer using germline whole- exome sequencing. European Journal of Human Genetics. 2017 Nov 1;25(11):1246-1252(NKI-AvL, VUmc) 1549. Mandalapu RS, Remzi M, de Reijke TM, Margulis V, Palou J, Kapoor A, Yossepowitch O, Coleman J, Traxer O, Anderson JK, Catto J, Delarosette JJMCH, O'Brien T, Zlotta A, Matin SF.Update of the ICUD-SIU consultation on upper tract urothelial carcinoma 2016: treatment of low-risk upper tract urothelial carcinoma.World journal of urology.2017;35(3):355-365 (AMC) 1550. Bex A, Albiges L, Ljungberg B, Bensalah K, Dabestani S, Giles RH, Hofmann F, Hora M, Kuczyk MA, Lam TB, Marconi L, Merseburger AS, Staehler M, Volpe A, Powles T.Updated European Association of Urology Guidelines Regarding Adjuvant Therapy for Renal Cell Carcinoma. Eur Urol 2017; 71:719-22 (NKI-AvL) 1551. Dommering CJ, Henneman L, van der Hout AH, Jonker MA, Tops CMJ, van den Ouweland AMW et al.Uptake of prenatal diagnostic testing for retinoblastoma compared to other hereditary cancer syndromes in the Netherlands. Familial Cancer. 2017 Apr 1;16(2):271-277(AMC, NKI-AvL, VUmc) 1552. Groen VH, Lock TMTW, Keizer B, Horenblas S, Meijer RP.Urothelial carcinoma in an orthotopic neobladder: an unusual pattern of recurrence and metastasis. BMJ Case Rep 2017; Oct 24:??? (NKI-AvL) 1553. Friedhoff P, Manelyte L, Giron-Monzon L, Winkler I, Groothuizen FS, Sixma TK.Use of Single-Cysteine Variants for Trapping Transient States in DNA Mismatch Repair. Methods Enzymol 2017; 592:77-101 (NKI- AvL) 1554. Tekatli H, van ’t Hof S, Nossent EJ, Dahele M, Verbakel WFAR, Slotman BJ et al.Use of Stereotactic Ablative Radiotherapy (SABR) in Non–Small Cell Lung Cancer Measuring More Than 5 cm. Journal of Thoracic Oncology. 2017 Jun 1;12(6):974-982 (VUmc) 1555. Köhle N, Drossaert CHC, Jaran J, Schreurs KMG, Leeuw IMVD, Bohlmeijer ET.User-experiences with a web-based self-help intervention for partners of cancer patients based on acceptance and commitment therapy and self-compassion: a qualitative study. BMC Public Health. 2017 Feb 28;17(1):255 (VUmc) 1556. Aselmaa A, van Herk M, Laprie A, Nestle U, Gotz I, Wiedenmann N, Schimek-Jasch T, Picaud F, Syrykh C, Cagetti LV, Jolnerovski M, Song Y, Goossens RH.Using a contextualized sensemaking model for interaction design: A case study of tumor contouring. J Biomed Inform 2017; 65:145-58 (NKI-AvL) 1557. Delaney AR, Dahele M, Tol JP, Kuijper IT, Slotman BJ, Verbakel WFAR.Using a knowledge-based planning solution to select patients for proton therapy. Radiotherapy and Oncology. 2017 Aug 1;124(2):263-270 (VUmc) 1558. Zhou F, Xie F, Jin K, Zhang Z, Clerici M, Gao R, van Dinther M, Sixma TK, Huang H, Zhang L, Ten Dijke P.USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling. EMBO J 2017; 36:1623-39 (NKI-AvL) 1559. Scheltema MJV, Tay KJ, Postema AW, de Bruin DM, Feller J, Futterer JJ, George AK, Gupta RT, Kahmann F, Kastner C, Laguna Pes MP, Natarajan S, Rais-Bahrami S, Rastinehad AR, de Reijke TM, Salomon G, Stone N, van Velthoven R, Villani R, Villers A, Walz J, Polascik TJ, Delarosette JJMCH.Utilization of

168 - Scientific publications multiparametric prostate magnetic resonance imaging in clinical practice and focal therapy: report from a Delphi consensus project.World journal of urology.2017;35(5):695-701 (AMC) 1560. Grivas N, Wit E, Tillier C, Van Muilekom E, Pos F, Winter A, van der Poel H.Validation and head-to-head comparison of three nomograms predicting probability of lymph node invasion of prostate cancer in patients undergoing extended and/or sentinel lymph node dissection. Eur J Nucl Med Mol Imaging 2017; 44:2213-26 (NKI-AvL) 1561. Stuiver MM, Kampshoff CS, Persoon S, Groen W, van Mechelen W, Chinapaw MJM et al.Validation and Refinement of Prediction Models to Estimate Exercise Capacity in Cancer Survivors Using the Steep Ramp Test. Archives of Physical Medicine and Rehabilitation. 2017 Nov 1;98(11):2167-2173(AMC, NKI-AvL, VUmc) 1562. Postema FAM, Hopman SMJ, De Borgie CAJM, Hammond P, Hennekam RC, Merks JHM et al.Validation of a clinical screening instrument for tumour predisposition syndromes in patients with childhood cancer (TuPS): Protocol for a prospective, observational, multicentre study. BMJ Open. 2017 Jan 1;7(1):e013237(AMC, VUmc) 1563. Bechten A, Wattjes MP, Purcell DD, Aliaga ES, Daams M, Brashear HR et al.Validation of an MRI Rating Scale for Amyloid-Related Imaging Abnormalities. Journal of Neuroimaging. 2017 May 1;27(3):318-325 (VUmc) 1564. van Spronsen MF, Westers TM, Rozema H, Ossenkoppele GJ, Kibbelaar RE, Hoogendoorn M et al.Validation of and proposals for refinements of the WHO 2016 classification for myelodysplastic syndromes. American Journal of Hematology. 2017 Nov 1;92(11):E631-E634 (VUmc) 1565. Wijmans L, Annema JT.Validation of needle-based confocal laser endomicroscopy.Endoscopy.2017;49(3):301 (AMC) 1566. Coelen RJS, Gaspersz MP, Labeur TA, van Vugt JLA, van Dieren S, Willemssen FçEJA, Nio CY, Ijzermans JNM, Klumpen H-J, Groot Koerkamp B, van Gulik TM.Validation of the Mayo Clinic Staging System in Determining Prognoses of Patients With Perihilar Cholangiocarcinoma.Clinical gastroenterology and hepatology.2017;15(12):1930-+ (AMC) 1567. van Maaren MC, van Steenbeek CD, Pharoah PDP, Witteveen A, Sonke GS, Strobbe LJA, Poortmans PMP, Siesling S.Validation of the online prediction tool PREDICT v20 in the Dutch breast cancer population. Eur J Cancer 2017; 86:364-72 (NKI-AvL) 1568. Dijkhoff RAP, Beets-Tan RGH, Lambregts DMJ, Beets GL, Maas M.Value of DCE-MRI for staging and response evaluation in rectal cancer: A systematic review. Eur J Radiol 2017; 95:155-68 (NKI-AvL) 1569. Mewes JC, Steuten LMG, IJsbrandy C, IJzerman MJ, van Harten WH.Value of Implementation of Strategies to Increase the Adherence of Health Professionals and Cancer Survivors to Guideline-Based Physical Exercise. Value Health 2017; 20:1336-44 (NKI-AvL) 1570. de Ridder M, Balm AJM, Baatenburg de Jong RJ, Terhaard CHJ, Takes RP, Slingerland M, Dik E, Sedee RJE, de Visscher JGAM, Bouman H, Willems SM, Wouters MW, Smeele LE, van Dijk BAC.Variation in head and neck cancer care in the Netherlands: A retrospective cohort evaluation of incidence, treatment and outcome. Eur J Surg Oncol 2017; 43:1494-502 (AMC,NKI-AvL) 1571. Opstelten JL, de Wijkerslooth LRH, Leenders M, Bac DJ, Brink MA, Loffeld BCAJ, Meijnen-Bult MëJF, Minderhoud IM, Verhagen MAMT, van Oijen MGH, Siersema PD.Variation in palliative care of esophageal cancer in clinical practice: factors associated with treatment decisions.Diseases of the esophagus.2017;30(2):1-7 (AMC) 1572. Spronk PER, van Bommel ACM, Siesling S, Wouters MWJM, Vrancken Peeters MTFD, Smorenburg CH.Variation in use of neoadjuvant chemotherapy in patients with stage III breast cancer: Results of the Dutch national breast cancer audit. Breast 2017; 36:34-8 (NKI-AvL) 1573. 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Scientific publications - 169 1579. Tillier C, van Muilekom HA, Bloos-van der Hulst J, Grivas N, van der Poel HG.Vesico-urethral anastomosis (VUA) evaluation of short- and long-term outcome after robot-assisted laparoscopic radical prostatectomy (RARP): selective cystogram to improve outcome. J Robot Surg 2017; 11:441-6 (NKI-AvL) 1580. Ingels A, Hew M, Algaba F, de Boer OJ, van Moorselaar RJ, Horenblas S, Zondervan P, de la Rosette JJ, Pilar Laguna Pes M.Vimentin over-expression and carbonic anhydrase IX under-expression are independent predictors of recurrence, specific and overall survival in non-metastatic clear-cell renal carcinoma: a validation study. World J Urol 2017; 35:81-7 (NKI-AvL) 1581. van de Velde ME, Kaspers GL, Abbink FCH, Wilhelm AJ, Ket JCF, van den Berg MH.Vincristine-induced peripheral neuropathy in children with cancer: A systematic review. Critical Reviews in Oncology / Hematology. 2017 Jun;114:114-130 (VUmc) 1582. Olaciregui-Ruiz I, Rozendaal R, van Oers RFM, Mijnheer B, Mans A.Virtual patient 3D dose reconstruction using in air EPID measurements and a back-projection algorithm for IMRT and VMAT treatments. Phys Med 2017; 37:49-57 (NKI-AvL) 1583. Dorlo TPC, Kip AE, Younis BM, Ellis SJ, Alves F, Beijnen JH, Njenga S, Kirigi G, Hailu A, Olobo J, Musa AM, Balasegaram M, Wasunna M, Karlsson MO, Khalil EAG.Visceral leishmaniasis relapse hazard is linked to reduced miltefosine exposure in patients from Eastern Africa: a population pharmacokinetic/pharmacodynamic study. J Antimicrob Chemother 2017; 72:3131-40 (NKI-AvL) 1584. Jelvehgaran P, Alderliesten T, Weda JJA, de Bruin DM, Faber DJ, Hulshof MCCM, van Leeuwen AGJM, van Herk MB, de Boer JF.Visibility of fiducial markers used for image-guided radiation therapy on optical coherence tomography for registration with CT: An esophageal phantom study.Medical physics.2017;44(12):6570-6582 (AMC) 1585. Teulings HE, Lommerts JE, Wolkerstorfer A, Nieuweboer-Krobotova L, Luiten RM, Bekkenk MW, van der Veen JPW.Vitiligo-like depigmentations as the first sign of melanoma: a retrospective case series from a tertiary vitiligo centre.British journal of dermatology.2017;176(2):503-506 (AMC) 1586. Lagerwaard F, Bruynzeel A, Palacios M, Bohoudi O, Slotman BJ.Volume Doubling Times of Brain Metastases From Different Histologies. International Journal of Radiation Oncology, Biology, Physics. 2017 Oct 1;99(2):E86-E86 (VUmc) 1587. Bronzwaer MES, Koens L, Bemelman WA, Dekker E, Fockens P.Volume of surgery for benign colorectal polyps in the last 11 years.Gastrointestinal endoscopy.2017 (AMC) 1588. Pouwer AW, Hinten F, van der Velden J, Smolders RGV, Slangen BFM, Zijlmans HJMA, IntHout J, van der Zee AGJ, Boll D, Gaarenstroom KN, Arts HJ, de Hullu JA.Volume-controlled versus short drainage after inguinofemoral lymphadenectomy in vulvar cancer patients: A Dutch nationwide prospective study. Gynecol Oncol 2017; 146:580-5887 (AMC,NKI-AvL) 1589. Haj Mohammad N, Bernards N, van Putten M, Lemmens VEPP, van Oijen MGH, van Laarhoven HWM.Volume-outcome relation in palliative systemic treatment of metastatic oesophagogastric cancer.European journal of cancer (Oxford, England.2017;78():28-36 (AMC) 1590. Kip AE, Kiers KC, Rosing H, Schellens JHM, Beijnen JH, Dorlo TPC.Volumetric absorptive microsampling (VAMS) as an alternative to conventional dried blood spots in the quantification of miltefosine in dried blood samples. J Pharm Biomed Anal 2017; 135:160-6 (NKI-AvL) 1591. van den Berg MMGA, Winkels RM, de Kruif JTCM, van Laarhoven HWM, Visser M, de Vries JHM, de Vries YC, Kampman E.Weight change during chemotherapy in breast cancer patients: a meta-analysis.BMC cancer.2017;17(1):259 (AMC) 1592. Lenderink AF, Sorgdrager B.Werkgerelateerde kanker in maat en getal.Tijdschrift voor bedrijfs- en verzekeringsgeneeskunde.2017;25(4):192-193 (AMC) 1593. Barr RG, Cosgrove D, Brock M, Cantisani V, Correas JM, Postema AW, Salomon G, Tsutsumi M, Xu H-X, Dietrich CF.WFUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography: Part 5. Prostate.Ultrasound in medicine & biology.2017;43(1):27-48 (AMC) 1594. Moldovan PC, van den Broeck T, Sylvester R, Marconi L, Bellmunt J, van den Bergh RC, Bolla M, Briers E, Cumberbatch MG, Fossati N, Gross T, Henry AM, Joniau S, van der Kwast TH, Matveev VB, van der Poel HG, De Santis M, Schoots IG, Wiegel T, Yuan CY, Cornford P, Mottet N, Lam TB, Rouviere O.What Is the Negative Predictive Value of Multiparametric Magnetic Resonance Imaging in Excluding Prostate Cancer at Biopsy? A Systematic Review and Meta-analysis from the European Association of Urology Prostate Cancer Guidelines Panel. Eur Urol 2017; 72:250-66 (NKI-AvL) 1595. van Hoppe S, Schinkel AH.What next? Preferably development of drugs that are no longer transported by the ABCB1 and ABCG2 efflux transporters. 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170 - Scientific publications 1600. Beckers RCJ, Lambregts DMJ, Schnerr RS, Maas M, Rao SX, Kessels AGH, Thywissen T, Beets GL, Trebeschi S, Houwers JB, Dejong CH, Verhoef C, Beets-Tan RGH.Whole liver CT texture analysis to predict the development of colorectal liver metastases-A multicentre study. Eur J Radiol 2017; 92:64-71 (NKI-AvL) 1601. Smets AMJB, Deurloo EE, Slager TJE, Stoker J, Bipat S.Whole-body magnetic resonance imaging for detection of skeletal metastases in children and young people with primary solid tumors - systematic review.Pediatric radiology.2017 (AMC) 1602. Littooij AS, Kwee TC, Enríquez G, Verbeke JIML, Granata C, Beishuizen A et al.Whole-body MRI reveals high incidence of osteonecrosis in children treated for Hodgkin lymphoma. British Journal of Haematology. 2017 Feb;176(4):637-642 (VUmc) 1603. van der Weele P, Meijer CJLM, King AJ.Whole-genome sequencing and variant analysis of human papillomavirus 16 infections. Journal of Virology. 2017 Oct 1;91(19) (VUmc) 1604. Beckers RCJ, Beets-Tan RGH, Schnerr RS, Maas M, Costa Andrade LA, Beets GL, Dejong CH, Houwers JB, Lambregts DMJ.Whole-volume vs segmental CT texture analysis of the liver to assess metachronous colorectal liver metastases. Abdom Radiol (NY) 2017; 42:2639-45 (NKI-AvL) 1605. Snaebjornsson P, Jonasson L, Olafsdottir EJ, van Grieken NCT, Moller PH, Theodors A, Jonsson T, Meijer GA, Jonasson JG.Why is colon cancer survival improving by time? A nationwide survival analysis spanning 35 years. Int J Cancer 2017; 141:531-9 (NKI-AvL, VUmc) 1606. Derks J, van Suylen RJ, Thunnissen E, den Bakker M, Groen H, Smit E, Damhuis R, van den Broek E, Speel EJ, Dingemans AC.Why we should improve current practice of diagnosing and treating pulmonary large cell neuroendocrine carcinomas in patients with advanced disease. Eur Respir J 2017; 50:(NKI-AvL) 1607. de Reijke TM, van Moorselaar JR.Words of Wisdom.European urology.2017;71(3):491-492 (AMC) 1608. Dewa CS, Trojanowski L, Tamminga SJ, Ringash J, McQuestion M, Hoch JS.Work-related experiences of head and neck cancer survivors: an exploratory and descriptive qualitative study.Disability and rehabilitation.2017;():1-7 (AMC) 1609. Dzikiewicz-Krawczyk A, Kok K, Slezak-Prochazka I, Robertus J-L, Bruining J, Tayari MM, Rutgers B, de Jong D, Koerts J, Seitz A, Li J, Tillema B, Guikema JEJ, Nolte IM, Diepstra A, Visser L, Kluiver J, van den Berg A.ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.Leukemia.2017;31(6):1470-1473 (AMC)

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172 - Scientific publications