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Next-Generation Sequencing Improves Thalassemia Carrier Screening Among Premarital Adults in a High Prevalence Population: the Dai Nationality, China
ORIGINAL RESEARCH ARTICLE © American College of Medical Genetics and Genomics Next-generation sequencing improves thalassemia carrier screening among premarital adults in a high prevalence population: the Dai nationality, China Jing He, MS1,2, Wenhui Song, PhD3, Jinlong Yang, BS3,5, Sen Lu, PhD4, Yuan Yuan, MS4, Junfu Guo, MS4, Jie Zhang, PhD2, Kai Ye, BS4, Fan Yang, BS4, Fangfang Long, MS3, Zhiyu Peng, PhD4, Haijing Yu, PhD5, Le Cheng, PhD3,6 and Baosheng Zhu, MS1,2 Purpose: Thalassemia is one of the most common monogenic dis- ite α- and β-thalassemia carriers were missed by traditional screens. eases in southwestern China, especially among the Dai ethnic group. The proportion of such α- and β-thalassemia carriers among the Dai Here, we explore the feasibility of a next-generation sequencing people is 8.6% (82/951). For β-thalassemia carriers, the high ratio (NGS) screening method specifically for the Dai people. (66/99) of CD26 mutations may suggest a correlation between CD26 Methods: Blood samples were obtained from Dai people for premar- and the environmental adaption of the Dai people. ital screening. Double-blind, parallel hemoglobinopathy screening Conclusions: Methodological comparisons demonstrate the superi- was conducted using both traditional hematological methods (red ority of NGS for both sensitivity and specificity, provide a compre- cell indexes and hemoglobin electrophoresis, then DNA sequencing) hensive assessment of thalassemia screening strategies, and indicate and an NGS approach. that NGS is a competitive screening method, especially among popu- Results: Among 951 tested individuals, we found a thalassemia car- lations with a high prevalence of disease. rier rate of 49.5% (471/951) using the NGS screen, in contrast to Genet Med advance online publication 26 January 2017 22.0% (209/951) found using traditional methods. -
Legal Setting Model About Forest Destruction Prevention Based on Indigenous People of Dalihan Na Tolu in North Sumatra
Proceedings of International Conference “Internationalization of Islamic Higher Education Institutions Toward Global Competitiveness” Semarang, Indonesia – September 20th - 21th, 2018 Paper No. B-53 Legal Setting Model About Forest Destruction Prevention Based On Indigenous People Of Dalihan Na Tolu In North Sumatra Anwar Sadat Harahap1 Ahmad Laut Hasibuan2 Universitas Muslim Nusantara (UMN) Al Washliyah Jalan Garu II No. 93 Medan [email protected] [email protected] Abstract - Many tribes and indigenous people exist throughout Indonesia. There are indigenous peoples who have their own traditional values in forest destruction prevention i.e indigenous people of Dalihan na Tolu with their local wisdom. The research used empirical legal research method. The approach used is anthropological approach, and sociological juridical. Long before the existence of regulation about in Indonesia, the indigenous people have had their own rules in preventing the forest destruction in North Sumatra. The custom law of Dalihan na Tolu has regulated about: the stages in implementing deliberation in preventing forest destruction, strategies that is implemented by the customary leader in preventing forest destruction, form of sanctions that is imposed on parties that commit forest destruction, implicit rules in indigenous people, dan the form of supervision in preventing forest destruction with the mechanism of controlling and supervisory that rest on the condition and potential of the indigenous people. Key Words: Legal Setting; Forest Destruction Prevention; Indigenous People of Dalihan na Tolu 1. Introduction In the last three years, massive forest destruction happened in the form of forest burning, timber theft, illegal logging, land clearing, timber smuggling, deforestation, expansion of agricultural areas and plantations in the forest area without regard to the condition of the surrounding environment. -
FORUM MASYARAKAT ADAT DATARAN TINGGI BORNEO (FORMADAT) Borneo (Indonesia & Malaysia)
Empowered lives. Resilient nations. FORUM MASYARAKAT ADAT DATARAN TINGGI BORNEO (FORMADAT) Borneo (Indonesia & Malaysia) Equator Initiative Case Studies Local sustainable development solutions for people, nature, and resilient communities UNDP EQUATOR INITIATIVE CASE STUDY SERIES Local and indigenous communities across the world are 126 countries, the winners were recognized for their advancing innovative sustainable development solutions achievements at a prize ceremony held in conjunction that work for people and for nature. Few publications with the United Nations Convention on Climate Change or case studies tell the full story of how such initiatives (COP21) in Paris. Special emphasis was placed on the evolve, the breadth of their impacts, or how they change protection, restoration, and sustainable management over time. Fewer still have undertaken to tell these stories of forests; securing and protecting rights to communal with community practitioners themselves guiding the lands, territories, and natural resources; community- narrative. The Equator Initiative aims to fill that gap. based adaptation to climate change; and activism for The Equator Initiative, supported by generous funding environmental justice. The following case study is one in from the Government of Norway, awarded the Equator a growing series that describes vetted and peer-reviewed Prize 2015 to 21 outstanding local community and best practices intended to inspire the policy dialogue indigenous peoples initiatives to reduce poverty, protect needed to take local success to scale, to improve the global nature, and strengthen resilience in the face of climate knowledge base on local environment and development change. Selected from 1,461 nominations from across solutions, and to serve as models for replication. -
FORUM MASYARAKAT ADAT DATARAN TINGGI BORNEO (FORMADAT) Borneo (Indonesia & Malaysia)
Empowered lives. Resilient nations. FORUM MASYARAKAT ADAT DATARAN TINGGI BORNEO (FORMADAT) Borneo (Indonesia & Malaysia) Equator Initiative Case Studies Local sustainable development solutions for people, nature, and resilient communities UNDP EQUATOR INITIATIVE CASE STUDY SERIES Local and indigenous communities across the world are 126 countries, the winners were recognized for their advancing innovative sustainable development solutions achievements at a prize ceremony held in conjunction that work for people and for nature. Few publications with the United Nations Convention on Climate Change or case studies tell the full story of how such initiatives (COP21) in Paris. Special emphasis was placed on the evolve, the breadth of their impacts, or how they change protection, restoration, and sustainable management over time. Fewer still have undertaken to tell these stories of forests; securing and protecting rights to communal with community practitioners themselves guiding the lands, territories, and natural resources; community- narrative. The Equator Initiative aims to fill that gap. based adaptation to climate change; and activism for The Equator Initiative, supported by generous funding environmental justice. The following case study is one in from the Government of Norway, awarded the Equator a growing series that describes vetted and peer-reviewed Prize 2015 to 21 outstanding local community and best practices intended to inspire the policy dialogue indigenous peoples initiatives to reduce poverty, protect needed to take local success to scale, to improve the global nature, and strengthen resilience in the face of climate knowledge base on local environment and development change. Selected from 1,461 nominations from across solutions, and to serve as models for replication. -
Leading Sector, Economic Structure and Competitiveness of Export Commodities
Adi WIJAYA, Zainal ILMI, Dio Caisar DARMA / Journal of Business, Economics and Environmental Studies 10-3 (2020) 23-33 23 Print ISSN: 2671-4981 / Online ISSN: 2671-499X JBEES website: http://www.jbees.or.kr/ Doi: 10.13106/jbees.2020.vol10.no3.23 Economic Performance: Leading Sector, Economic Structure and Competitiveness of Export Commodities Adi WIJAYA1, Zainal ILMI2, Dio Caisar DARMA3 Received: January 15, 2020. Revised: January 23, 2020. Accepted: July 05, 2020 Abstract Purpose: The purpose of this study is for the leading sector, a pattern of shifting structure of the economic sector, and community export competitiveness on the economy Malinau Regency. Research design, data, and methodology: The type of data used is secondary data with a quantitative approach of 2009-2018. The study data used Location Quotient (LQ), Shift Share Analysis (SSA), and Revealed Comparative Advantage (RCA) analysis tools. Results: There are 6 leading sectors: agriculture; electricity, gas, and clean water; building and construction; trade, hotels, and restaurants. That has been classified has changed the economic structure of the Malinau Regency from the secondary sector to the tertiary and primary sectors in 10 years. While, community export competitiveness of the Malinau Regency through RCA Analysis, see if the export products of coal and excavation (types A, B, C) are shown to have a higher comparative advantage with comparative advantage. This shows that only a few commodities that can provide the good performance of export. Conclusions: Analysis of economic growth in the Malinau Regency after regional autonomy shows that there has been a shift in the economic structure of the economy which is dominated by the structure of the primary sector. -
Trials of a Tibetan Monk: the Case of Tenzin Delek
Human Rights Watch February 2004, Vol. 16, No. 1 (C) Trials of a Tibetan Monk: The Case of Tenzin Delek Map 1: Provinces and Autonomous Regions of the People’s Republic of China..............................1 Map2: Sichuan Province and Surrounding Areas....................................................................................2 Map 3: Southeastern Section of Kardze/Ganzi Tibetan Autonomous Prefecture............................3 I. Summary ....................................................................................................................................................5 Recommendations ...................................................................................................................................7 A Note on Methodology.........................................................................................................................8 II. Introduction...........................................................................................................................................10 Tenzin Delek ..........................................................................................................................................12 Lobsang Dondrup..................................................................................................................................14 Bombs......................................................................................................................................................15 III. Arrests...................................................................................................................................................17 -
North Kalimantan Indonesia
JURISDICTIONAL SUSTAINABILITY PROFILE NORTH KALIMANTAN INDONESIA FOREST NO FOREST DEFORESTATION (1990-2015) LOW-EMISSION RURAL DEVELOPMENT (LED-R) AT A GLANCE DRIVERS OF Infrastructure development • Newest province in Indonesia, established in 2012 DEFORESTATION Fisheries (formerly part of East Kalimantan) Industrial mining TANJUNG SELOR Large-scale legal logging • 30% of provincial population are migrants from other provinces, with recent migrants settling in urban areas; Large-scale agriculture g population growth agricultural land conversion, AVERAGE ANNUAL 11.33 Mt CO2 (2010-2015) Includes Data sources: production decrease & increased reliance on imports EMISSIONS FROM above-ground biomass & peat Socio-economic: BPS decomposition Deforestation: Derived DEFORESTATION from Ministry of • 90% of provincial area contained in forests zoned for AREA 68,996 km2 Forestry data protection, conservation & production POPULATION 716,407 (2018) • Palm oil accounts for 62% of agricultural production HDI 69.84 (2017) Deforestation GDP USD 4.1 billion GDP • Kayan Mentarang National Park (KMNP), one of the Average yearly (2017) deforestation (using 51 50 largest conservation areas in SE Asia & a central part of the FREL baseline GINI 0.303 (2018) 2 period 1990-2012) TRILLIONS IDR the Heart of Borneo Initiative, encompasses over 15% 6 40 MAIN ECONOMIC of the jurisdiction (13,600 km2) Fish farming ACTIVITIES 30 Extraction of non-renewable 4 • Endangered Bornean elephants in the Sebuku forest resources 20 are protected by national regulations & culturally -
Seeking the State from the Margins: from Tidung Lands to Borderlands in Borneo
Seeking the state from the margins From Tidung Lands to borderlands in Borneo Nathan Bond ORCID ID: 0000-0002-8094-9173 A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy. December 2020 School of Social and Political Sciences The University of Melbourne i Abstract Scholarship on the geographic margins of the state has long suggested that life in such spaces threatens national state-building by transgressing state order. Recently, however, scholars have begun to nuance this view by exploring how marginal peoples often embrace the nation and the state. In this thesis, I bridge these two approaches by exploring how borderland peoples, as exemplars of marginal peoples, seek the state from the margins. I explore this issue by presenting the first extended ethnography of the cross-border ethnic Tidung and neighbouring peoples in the Tidung Lands of northeast Borneo, complementing long-term fieldwork with research in Dutch and British archives. This region, lying at the interstices of Indonesian Kalimantan, Malaysian Sabah and the Southern Philippines, is an ideal site from which to study borderland dynamics and how people have come to seek the state. I analyse understandings of the state, and practical consequences of those understandings in the lives and thought of people in the Tidung Lands. I argue that people who imagine themselves as occupying a marginal place in the national order of things often seek to deepen, rather than resist, relations with the nation-states to which they are marginal. The core contribution of the thesis consists in drawing empirical and theoretical attention to the under-researched issue of seeking the state and thereby encouraging further inquiry into this issue. -
'Undergoer Voice in Borneo: Penan, Punan, Kenyah and Kayan
Undergoer Voice in Borneo Penan, Punan, Kenyah and Kayan languages Antonia SORIENTE University of Naples “L’Orientale” Max Planck Institute for Evolutionary Anthropology-Jakarta This paper describes the morphosyntactic characteristics of a few languages in Borneo, which belong to the North Borneo phylum. It is a typological sketch of how these languages express undergoer voice. It is based on data from Penan Benalui, Punan Tubu’, Punan Malinau in East Kalimantan Province, and from two Kenyah languages as well as secondary source data from Kayanic languages in East Kalimantan and in Sawarak (Malaysia). Another aim of this paper is to explore how the morphosyntactic features of North Borneo languages might shed light on the linguistic subgrouping of Borneo’s heterogeneous hunter-gatherer groups, broadly referred to as ‘Penan’ in Sarawak and ‘Punan’ in Kalimantan. 1. The North Borneo languages The island of Borneo is home to a great variety of languages and language groups. One of the main groups is the North Borneo phylum that is part of a still larger Greater North Borneo (GNB) subgroup (Blust 2010) that includes all languages of Borneo except the Barito languages of southeast Kalimantan (and Malagasy) (see Table 1). According to Blust (2010), this subgroup includes, in addition to Bornean languages, various languages outside Borneo, namely, Malayo-Chamic, Moken, Rejang, and Sundanese. The languages of this study belong to different subgroups within the North Borneo phylum. They include the North Sarawakan subgroup with (1) languages that are spoken by hunter-gatherers (Penan Benalui (a Western Penan dialect), Punan Tubu’, and Punan Malinau), and (2) languages that are spoken by agriculturalists, that is Òma Lóngh and Lebu’ Kulit Kenyah (belonging respectively to the Upper Pujungan and Wahau Kenyah subgroups in Ethnologue 2009) as well as the Kayan languages Uma’ Pu (Baram Kayan), Busang, Hwang Tring and Long Gleaat (Kayan Bahau). -
Yunnan Provincial Highway Bureau
IPP740 REV World Bank-financed Yunnan Highway Assets management Project Public Disclosure Authorized Ethnic Minority Development Plan of the Yunnan Highway Assets Management Project Public Disclosure Authorized Public Disclosure Authorized Yunnan Provincial Highway Bureau July 2014 Public Disclosure Authorized EMDP of the Yunnan Highway Assets management Project Summary of the EMDP A. Introduction 1. According to the Feasibility Study Report and RF, the Project involves neither land acquisition nor house demolition, and involves temporary land occupation only. This report aims to strengthen the development of ethnic minorities in the project area, and includes mitigation and benefit enhancing measures, and funding sources. The project area involves a number of ethnic minorities, including Yi, Hani and Lisu. B. Socioeconomic profile of ethnic minorities 2. Poverty and income: The Project involves 16 cities/prefectures in Yunnan Province. In 2013, there were 6.61 million poor population in Yunnan Province, which accounting for 17.54% of total population. In 2013, the per capita net income of rural residents in Yunnan Province was 6,141 yuan. 3. Gender Heads of households are usually men, reflecting the superior status of men. Both men and women do farm work, where men usually do more physically demanding farm work, such as fertilization, cultivation, pesticide application, watering, harvesting and transport, while women usually do housework or less physically demanding farm work, such as washing clothes, cooking, taking care of old people and children, feeding livestock, and field management. In Lijiang and Dali, Bai and Naxi women also do physically demanding labor, which is related to ethnic customs. Means of production are usually purchased by men, while daily necessities usually by women. -
697 Significance of Informal Cross Border Trade
Kuntoro Boga Andri SIGNIFICANCE OF INFORMAL CROSS BORDER TRADE INDONESIA AND MALAYSIA FOR AGRICULTURAL COMMODITIES DEVELOPMENT IN NUNUKAN REGENCY, EAST KALIMANTAN Kuntoro Boga Andri1 Abstract The border region of Nunukan Regency with the City of Tawau, Sabah state, Malaysia has great potential to be developed as a center of agricultural production and raw material supplier. The research aims to: (a) Investigating the structure, the actors and the potency of agribusiness in the region, (b) Identification of informal cross border trade mechanisms in Nunukan-Tawau on agricultural commodities (c) Determine the strategy and policy improvements of ongoing trading system. The study shown Nunukan economic structure was still dominated by the potential of agricultural commodities, forest products, and cross-border trade activities through Sebatik Island. Lack of support infrastructure and accessibility of product flow causes agricultural commodities in the border region was inhibited. To improve the efficiency of the lucrative trade, and development of agribusiness in the Nunukan border region, it is needed synergies between farmers, traders, businessmen and strong support from the government. Keywords: informal cross border trade, agricultural commodities, Nunukan, East Kalimantan Introduction The East Kalimantan border region stretching from east to west along the ± 1038 km or an area of 57731.64 km2 (23.54% of the area of East Kalimantan), with extensive details of the border area of 12,128 Km2 of Nunukan Regency (4.95% of the area of East Kalimantan ), West Kutai Regency 8911.1 km2 (3.6%), and Malinau Regency 36692.54 km2 (14.96%). This region consists of 12 sub district which includes the sub district of Long and Long Pahangai Apari in West Kutai Regency, Kayan Hulu, Kayan Hilir and Pujungan in Malinau Regency, subdistrict of Krayan, South Krayan, Lumbis, Sebuku, Nunukan, Sebatik islands and West Sebatik islands in Nunukan Regency. -
Pre-Scoping Report Kalimantan EC Final Draft.V2013.11.19
SEA for Indonesian Master Plan for Accelerated Economic Development (MP3EI) Pre-scoping Report (Final Draft) Kalimantan Economic Corridor Ministry Of Foreign Affairs Of Denmark Draft Report November 2013 This report has been prepared under the DHI Business Management System certified by DNV to comply with Occupational Health and Quality Management Environmental Management Safety Management ISO 9001 ISO 14001 OHSAS 18001 Pre-Scoping Report - Kalimantan Economic Corridor / JVB / 2013-11 SEA for Indonesian Master Plan for Accelerated Economic Development (MP3EI) Pre-scoping Report (Final Draft) Kalimantan Economic Corridor Prepared for Ministry Of Foreign Affairs Of Denmark Represented by Mr Peter Oksen Project manager Joshua Jon van Berkel Project number 61800814 Prepared by Michal Musil, Yesaya Hardyanto Final Draft submitted 19/11/2013 Approval date Revision Classification Open/Restricted/Confidential DHI Water & Environment (S) Pte Ltd• 1 Cleantech Loop • #03-05 CleanTech One • Singapore• 637141 Telephone: +65 67776330 • Telefax: +65 67773537 • [email protected]• This page is intentionally left blank Pre-Scoping Report - Kalimantan Economic Corridor / JVB / 2013-11 CONTENTS 1 Introduction ................................................................................................................. 1 1.1 Background on MP3EI SEA ........................................................................................................... 1 1.2 SEA Process for Economic Corridors and Current Phase ...........................................................