ROC AbstractU Review August 2015 Faculty: Andrew Huerta, PhD Andrew Faculty: UROC - PREP Executive Director: Andrew Carnie, PhD PhD Carnie, Andrew Director: Executive Program Director: Donna Treloar, MA Treloar, Donna Director: Program UROC-PREP, funded by the University of Arizona, is a highly structured academic, academic, structured a highly is of Arizona, University the by funded UROC-PREP, of University students at the undergraduate for program research and mentoring, are that backgrounds from come program year-round in the All students Arizona. research in pursuing interested are and education in graduate underrepresented or PhD). (Master’s degrees oriented graduate 86 UROC PREP Kenia Jordana Carrera UROC Prep

University of arizona Tucson, Arizona PI: Dr. John JB Allen ASSOCIATIONS BETWEEN MILD TRAUMATIC BRAIN INJURIES, EVENT-RELATED PO- TENTIALS, AND MAJOR DEPRESSION DISORDER

Abstract: Over the years, the relationship between mild traumatic brain injuries (mTBIs) and depres- sion has been thoroughly examined, and a strong positive correlation between the two variables has UROC - PREP been found (Chrisman & Richardson, 2014; Guskiewicz et al., 2007; Holsinger et al., 2002). However, not many researchers have investigated what happens structurally and functionally to the brain that allows this relationship to exist. In the past, concussions and severe depression have both been linked to a smaller error-related negativity (ERN) amplitude (Broglio et al., 2011; Duncan et al., 2011; Olvet, Klein, & Hajcak, 2010; Pontifex et al., 2009). Here, we proposed that a smaller amplitude in ERN is the mediating factor between mTBIs and depression. The present study evaluated a population of high-impact sports athletes with a history of mTBIs for levels of depression and ERN amplitude. All the participants, N=17, completed the Beck Depression Inventory-II (BDI-II) to assess for severity of depression, and a modified flankers task to evaluate for ERN amplitude. Although not statistically significant, the results show a me- diator model trend where the correlation between concussions and depression decreased once the ERN was controlled for. Even though these findings suggest that the ERN is not a mediating factor, if further studies with larger sample sizes and controls were conducted a statistical significance could appear.

87 - - - Anne Cress fluorescence and confocal microscopy the distribution and influence of β4 on collective migration. The migration. collective of β4 on influence and the distribution microscopy confocal and fluorescence conditions of two different Under dependent. integrin was α6β4 migration collective that showed results to determine work will be Future formation. network prevented the loss of α6β4 integrin 3-D cell growth adhesion complexes. seen in α6β4 containing the networks form necessary to the minimal components sue specific heterodimeric transmembrane proteins. One of the integrins, α6β4, is only observed normal α6β4, is only observed One of the integrins, proteins. transmembrane sue specific heterodimeric be a to tumor cells and postulated in prostate observed β4 are of integrin variants epithelia, but now - collec cancer migrates prostate that stipulates One model of metastasis in metastasis. factor defining determine to is research as single cells. The aim of the current to migrating as opposed in networks tively tumor cells. Experiments prostate in cell migration collective of of α6β4 on the progression the influence immuno by cell line and determine in an immortalized the β4 integrin knockdown designed to were In order for cancer to metastasize, it must first gain the ability to become invasive. The Amer invasive. to become gain the ability first it must metastasize, to cancer for In order Abstract: ican Cancer Society reports that prostate cancer is the second leading cause of cancer death in males, death of cancer leading cause is the second cancer prostate that reports Society Cancer ican - During metasta 2015). Cancer Society, (American to metastasis attributed are deaths and 90% of cancer tis integrins- are signal deregulation for axis and a main target deregulated cellular signals are sis many niversity of arizona niversity THE INFLUENCE OF INTEGRIN Β4 EXPRESSION IN THE COLLECTIVE MIGRATION OF OF MIGRATION COLLECTIVE THE IN EXPRESSION Β4 INTEGRIN OF INFLUENCE THE CELLS TUMOR PROSTATE U Arizona Tucson, PI: Dr. Janette Esperanza Esperanza Janette Carrillo Prep UROC UROC PREP 88 - - . Jean-Marc Fellous . Jean-Marc Oxytocin is a neuropeptide with widespread effects on the socio-emotional behavior of behavior on the socio-emotional effects with widespread is a neuropeptide Oxytocin Abstract: im- to has been shown oxytocin of administration intranasal mammalian species. In humans, various a re- pro-socially as and act with others states affective to share the ability empathy, emotional prove affective of identification and accurate contagion such as emotional processes, sult, and other related the saliency of emotional cues increases administration oxytocin that Studies suggest in others. states it is in or whether empathy facilitates only oxytocin yet unclear whether though it is in social settings, of the promotion is necessary for system oxytocin the endogenous that hypothesize We required. fact and pro-social contagion both emotional of displaying capable are rats that Evidence behavior. empathic system in oxytocin of the role of the investigation for the animal model an interesting action provides measuring empath used a model for this idea, we test to In order of empathy. expression the behavioral ic behavior in rats, in which one rat can prevent the delivery of a footshock to a conspecific by altering by altering a conspecific to of a footshock the delivery prevent can in which one rat in rats, ic behavior intracerebralventricular that show results Our preliminary task. in an operant behavior lever-pressing dis (0.75μg/5.0μl) test to the prior antagonist 20 minutes receptor oxytocin of a selective administration their conspecific to delivered number of shocks the increasing by in a male rat behavior empathic rupts system oxytocin the endogenous for role a critical results suggest These conditions. control to compared such as deficient, is in which empathy for disorders target a potential indicating behavior, in empathic disorder. personality anti-social niversity of arizona niversity THE ROLE OF OXYTOCIN IN EMPATHY IN THE RAT THE IN EMPATHY IN OXYTOCIN OF ROLE THE PI: Dr U Arizona Tucson, Karen Guadalupe Cruz Guadalupe Karen Prep UROC UROC PREP 89 -

. Alfred W. Kaszniak . Alfred W. The present study examined self-compassion in a sample of undergraduate students (N = students of undergraduate in a sample self-compassion examined study The present Abstract: one’s of being understanding that emphasizes self-attitude as a positive is defined 73). Self-compassion re- studies of the been have in balance. Although there feelings and thoughts keeping and flaws own is currently there and depression, anxiety, with self-esteem, shares self-compassion that lationships and has with implicit self-esteem self-compassion relationships the has investigated that no literature most that is of the self evaluation as an unconscious is defined Implicit self-esteem existential-anxiety. refers anxiety Existential objects (e.g. name letters). of self-associated in the appraisals found commonly - be negative would self-compassion that hypothesized meaningless, and guilt. We of death, anxiety to with correlated would be positively implicit self-esteem and that with existential-anxiety ly correlated explicit self-esteem. with correlation would be higher than the this correlation and that self-compassion Scale, Response Rumination Questionnaire, Anxiety Existential Form, Scale-Short The Self-Compassion using the Name Letter Implicit self-esteem, study. in this utilized were Scale Self-Esteem and Rosenberg signif were There ps>.05). (rs<|0.1|, or self-esteem with either self-compassion not correlated was Test, icant negative relationships found between self-compassion and existential anxiety (r=–.41, p<.01) and (r=–.41, anxiety existential and self-compassion between found relationships negative icant and about death anxiety implies that (r=–0.57, p<.01). This potentially and rumination self-compassion treat to option it a viable which makes the use of self-compassion through attenuated can be rumination Disorder. Stress illnesses, such as Post-Traumatic mental related

niversity of arizona niversity SELF-COMPASSION: A CORRELATIONAL EXPLORATION CORRELATIONAL A SELF-COMPASSION:

PI: Dr U Arizona Tucson, UROC Prep UROC Rosa Roberto Juan De La De Juan Roberto UROC PREP 90 - -

Michelle M. Perfect

- Be Positive School Wide attending of the effects explore to was The purpose of this study Abstract: of behaviors on the aggressive-disruptive schools status and Supports (SWPBIS) Interventions havioral with T1DM will have students that was mellitus (T1DM). The hypothesis 1 diabetes with Type students compared schools status SWPBIS in were if they behaviors aggressive-disruptive teacher-rated lower aggresivity teacher-reported between the relations examined we schools. Also, status non-SWPBIS to conduct was study to schools. The attitude and teachers, with relations self-esteem, and self-reported the administration were study of the with T1DM. The measures ed with a sample of 71 participants of the and the identification (BASC-2) Edition Second Children, for System Assessment of the Behavior none of that findings indicated Preliminary information. based on school district status schools’ SWPBIS schools had status in SWPBIS students that a trend was there However, supported. were the hypotheses schools. Indeed, further status in non-SWPBIS teachers than teachers of their perceptions positive more and the SWPBIS implementation about information accurate sample and more with a larger research to the contributes study the results. Overall, better provide would and reliability validity schools’ status youth with T1DM. youth such as at-risk in problems of behavioral understanding better niversity of arizona niversity THE EFFECTS OF ATTENDING A SCHOOL WIDE POSITIVE BEHAVIORAL INTERVEN BEHAVIORAL POSITIVE WIDE SCHOOL A ATTENDING OF EFFECTS THE TIONS AND SUPPORTS (SWPBIS) STATUS SCHOOLS ON AGGRESSIVE-DISRUPTIVE AGGRESSIVE-DISRUPTIVE ON SCHOOLS STATUS (SWPBIS) SUPPORTS AND TIONS (T1DM) MELLITUS DIABETES 1 TYPE WITH YOUTH OF BEHAVIORS

PI: Dr. U Arizona Tucson,

UROC Prep UROC Erika Elizalde Erika UROC PREP 91 - - -

Melissa barnett Melissa ing Mexican origin mothers rather than describing what the support networks of Mexican origin mothers origin mothers Mexican of networks the support what than describing rather origin mothers ing Mexican study This family. inside and outside the individuals role of other supportive the investigating by look like support, them providing individuals are on what reports sample of mothers’ is based on a community whether individuals), and of identified the amount quantifying (by of these support networks the size and their these mothers between contact of or amount with the size is associated satisfaction maternal moth American and Mexican Mexican between differences any were there Whether support networks. with support satisfaction maternal Findings indicate also examined. was these variables concerning ers in the support of contact while the amount of contact, or amount with size isn’t associated network and Mexican between differences significant statistically are Also there with size. is associated network Specifically, of their support networks. and the size of contact in the amount mothers American Mexican - direc for future Suggestions and smaller support networks. less contact report mothers Mexican-born Since programs. family support and intervention work in who professionals towards focused tions are recommen- the primary characteristics, parenting on positive parents on educating focus these programs and parents in supporting involved individuals focused on different servicesto open up these is dation and positive on the negative family members include educating recommendation Moreover, children. in support networks. have can impacts they Although Latino mothers typically report considerable social support from the whole family, family, the whole social support from considerable report typically mothers Although Latino Abstract: in support have grandparents and partners romantic role the on reporting has mainly focused research

niversity of Arizona niversity UROC Prep UROC PERCEIVED SOCIAL SUPPORT IN MEXICAN ORIGIN MOTHERS WITH TODDLERS AB TODDLERS WITH MOTHERS ORIGIN MEXICAN IN SUPPORT SOCIAL PERCEIVED STRACT PI: Dr.

U Arizona Tucson, Ericka Encinas Ericka UROC PREP 92 -

Heidi Mansour The pulmonary route has shown to offer many advantages to deliver drugs and treat local local drugs and treat to deliver advantages many offer to has shown The pulmonary route Abstract: way a common become (DPIs) have inhalers dry powder diseases. Furthermore, diseases and systemic for it difficult make that limitations are there However, the pulmonary system. drugs through deliver to to enhance can be an approach inhalable pro-liposomes surpass these limitations, To the drug delivery. designed and were pro-liposomes study, In the current the pulmonary route. through drug delivery for technique particle engineering drying, a novel co-spray technique of the as DPIs employing optimized phospholipids, synthetic composed of were They powders. pharmaceutical state of solid the formulation was B (AmB) (DPPG). Amphotericin (DPPC) and dipalmitoylphatidyglycerol dipalmitoylphosphatidycholine - Phys infections. fungal severe to treat commonly used a drug study, for this as a model drug utilized in order characterized comprehensively were pro-liposomes formulated of these properties iochemical In vitro content. water residual and morphology, phase transitions, solid-state size, geometric analyze to to pulmonary offer these pro-liposomes that the enhancement test to performed were cellular studies pro-liposomes formulated comparing the drug alone and the effects Toxicological drug administration. re- electrical and transepithelial pulmonary cell viability assay, methods, different using two tested were was done performance dispersion aerosol In addition, in vitro conditions. air-interface (TEER) at sistance of for the analysis (HandiHaler®) (NGI™) with a human DPI device Impactor™ Generation using the Next properties. deposition and particle aerodynamic powder

niversity of Arizona niversity UROC Prep UROC ADVANCED SPRAY DRIED PRO-LIPOSOMES AS DRY POWDER INHALER: AN AD AN INHALER: POWDER DRY AS PRO-LIPOSOMES DRIED SPRAY ADVANCED VANCED DRUG DELIVERY SYSTEM FOR PULMONARY DRUG ADMINISTRATION DRUG PULMONARY FOR SYSTEM DELIVERY DRUG VANCED PI: Dr.

U Arizona Tucson, Alexan Gomez Alexan UROC PREP 93 - - -

Pak Kin Wong Pak Accurate and timely identification of bacterial infections is critical to the effective imple the to critical infections is bacterial of and timely identification Accurate Abstract: to distinguish biosensors the ability of electrochemical Herein, care. in health of treatments mentation of representative Four bacteria examined. within a single blood sample is specific species of bacteria Staphylococcus blood samples, including the bacterium into inoculated were blood pathogens typical probes and detector Capture mirabilis. aeruginosa, and Proteus Pseudomonas Escherichia coli, aureus, the of detecting pair which is capable probe as a universal as well each bacteria for used included pairs with the and then hybridized lysis through obtained rRNA was 16s The bacterial of all bacteria. presence detection of the 16s probe. Amperic detector and fluorescein-modified probe capture thiol-modified (TMB) and H2O2 with a horserad Tetramethylbenzidine of the interaction through achieved rRNA was five placed on were probe. Samples detector to the bound anti-fluorescein ish peroxidase-conjugated Samples universal. either species-specific or a pair of probes, with each chip containing biosensor chips, each amongst distributed and plain blood were each individual bacterium a mix of bacteria, containing under an hour. be read able to each sample were signals for Beginning with lysis, 16 electrodes. chip’s detec- pair, with the probe for each was achieved probes using the specific of bacteria Differentiation the from 95% of the signal obtained averaging bacteria mixed containing the sample tion signal from rapidly identify to possess the potential biosensors Electrochemical one bacterium. samples containing effective an can become in blood samples, and with further development pathogens bacterial infecting diagnosis. aid in point-of-care to tool

niversity of arizona niversity APPLICATION OF ELECTROCHEMICAL BIOSENSORS TO THE IDENTIFICATION OF BAC OF IDENTIFICATION THE TO BIOSENSORS ELECTROCHEMICAL OF APPLICATION POINT-OF-CARE THE AT INFECTIONS BLOOD TERIAL

PI: Dr. U Arizona Tucson,

UROC Prep UROC Lindsie Jeffries Lindsie UROC PREP 94 - - Armin Sorooshian In recent decades, the southwestern United States (Southwest) has been moving towards a towards has been moving (Southwest) States United the southwestern decades, In recent Abstract: To emissions and wildfires. dust more promote generally in the Southwest Such changes climate. dryer region because study is chosen as the Arizona events, pollution of such aerosol characteristics examine recent in and land use changes growth population rapid and has experienced it is within the Southwest ex of the frequency quantify to sites monitoring EPA eight from data uses surface study The years. treme events as a function of month and year (2001-2014) and classifying the events according to their according events and classifyingyear (2001-2014) the and as a function of month events treme source. of PM2.5 (i.e., particulate concentrations for mass independently identified first are events Extreme defined are PM10, and fine soil, which less than 2.5 micrometers), diameters with aerodynamic matter Next, month. in each concentrations respective their with associated specific criteria establishing by = dust criteria: following by using the events or dust as wildfires further classified are these events (and not fine levels extreme reached = PM2.5 smoke levels; extreme reached PM10 and fine soil levels and Asian dust between distinguish to data using satellite then analyzed were events soil). The dust to 5-15% due wildfires, due to were the either sites at events 5-21% of the extreme Between dust. local inter-an no significant exhibits events of total The frequency dust. local and 22-36% due to Asian dust, in occurred events extreme the most 2001 and 2014. Depending on the site, between nual change or December. August, April, July, February, either January, niversity of Arizona niversity FREQUENCY AND CHARACTERIZATION OF EXTREME AEROSOL EVENTS IN THE THE IN EVENTS AEROSOL EXTREME OF CHARACTERIZATION AND FREQUENCY ARIZONA IN ANALYSIS STUDY CASE A STATES: UNITED SOUTHWESTERN PI: Dr. U Arizona Tucson, David Humberto Lopez Humberto David Prep UROC UROC PREP 95 - - Jonathan Vande Geest Vande Jonathan crease in the demand for the development of therapeutic biocompatible vascular grafts. In this study, study, In this grafts. vascular biocompatible of therapeutic the development in the demand for crease with biopolymer scaffolds electrospun of cellularizing the feasibility test to targeted were experiments these cell lines whether investigate to endothelial cells (hCB-ECs) derived blood cord human umbilical Endothelial immunocompatibility. recipient and thrombogenesis with graft problems mitigate can endothelial-marker into differentiated blood and cord umbilical from isolated were cells progenitor Previ immunocytochemistry. and cytometry flow by characterized then were which lines cell producing gelatin a by electrospinning fabricated were constructs sheet flat ously designed compliance-matched isolated against and viability growth cell compare to solution and seeded with hCB-ECs and fibrinogen of thrombogenesis, levels the relative examine To endothelial cells (HUVECs). vein human umbilical ac- and a platelet microscopy scanning electron by quantified each cell type was adhesion to platelet The HUVECs. against by hCB-ECs caused activation platelet contrast to was performed assay state tivity adherence, platelet reduced endothelial cell markers, possess classical hCB-ECs that indicated results flat sheet seeded the hCB-EC lines. Furthermore, to HUVEC compared activation platelet and reduced that suggest These findings points. for all chosen time ranges cell viability sufficient displayed scaffolds reduce the can feasible and is vascular grafts compliance-matched to endothelialize utilizing hCB-ECs constructs endothelialized on placing the shall focus studies Future in vitro. of thrombogenesis levels functionality. further assess loading to under biomechanical Heart disease is the leading cause of death in the United States, resulting in a drastic in in a drastic resulting States, in the United of death Heart disease is the leading cause Abstract: niversity of arizona niversity TISSUE ENGINEERED VASCULAR GRAFTS SEEDED WITH HUMAN UMBILICAL CORD CORD UMBILICAL HUMAN WITH SEEDED GRAFTS VASCULAR ENGINEERED TISSUE CELLS ENDOTHELIAL DERIVED BLOOD PI: Dr. U Arizona Tucson, David Maestas David Prep UROC UROC PREP 96 - . Allison Ewing-Cooper . Allison Parents who consistently are involved in each aspect of their child’s life, even when their even life, in each aspect of their child’s involved are who consistently Parents Abstract: parenting This particular parenting. helicopter as practicing characterized are college attend to go children i.e., those born during of the Millennial Generation children who have parents amongst common is style gen- of the millennial and children parents helicopter between relationship year 1982. The the and after and of the parental outcomes consider different to research previous through explored has been eration vol- that students’ college of 259 the relationship This paper examines child as individuals and as a set. parents with their relationship of their their perceptions regarding a questionnaire to responded untarily relationship the understand better to proposed were questions research Four education. and their college The findings support participants. the amongst patterns involvement and parent communication between education student for a pays who between relationship nonzero is a significant there that the hypothesis millenni were respondents The majority of their education. about with their parents and communication als and characterized their parents as practicing the helicopter parenting style. This was seen in the results was seen in the style. This parenting the helicopter as practicing their parents als and characterized to interesting was It involvement. parental of relationship and the patterns communication of frequent with have their parents of involvement with the level content are 90% of the participants that discover life. their academic niversity of arizona niversity COMMUNICATION BETWEEN MILLENNIAL GENERATION COLLEGE STUDENTS AND AND STUDENTS COLLEGE GENERATION MILLENNIAL BETWEEN COMMUNICATION PARENTS HELICOPTER THEIR PI: Dr U Arizona Tucson, Caldonia Mask Caldonia Prep UROC UROC PREP 97 - - - Paul Ferré Paul ously, then a relationship can be determined between electrical resistance, water content, and matric and matric content, water resistance, electrical between can be determined then a relationship ously, year. next over the continue will research over and yet project is not phase of this testing The potential. would content water and resistance electrical between relationship finding a that it is believed However, to floodplain management. agriculture aid fields from could that be developed to technology for allow The objective of the current study is to explore if electrical properties of soils, such as elec properties if electrical explore to study is of the current The objective Abstract: The methods content. water about the soil, such as properties infer be used to can resistance, trical water soil a to develop experiment column of a hanging consisted this question answer to employed the field and a sample from take to also built in order was column of soils. A soil curves characteristic cells several this task, accomplish to In order of the soil, undisturbed. resistance the electrical measure hy well as clean sands. Our as resistivity electrical with known using solutions built and tested were run simultane able to are methods resistance and soil electrical if the hanging column potheses is that niversity of arizona niversity ELECTRICAL RESISTANCE AS A METHOD OF QUANTIFYING WATER CONTENT IN IN CONTENT WATER QUANTIFYING OF METHOD A AS RESISTANCE ELECTRICAL SOILS PI: Dr. U Arizona Tucson, Katarena Matos Katarena Prep UROC UROC PREP 98 - - John P. Willerton John P. ternal variable of outside influence by third parties. Implications of this research suggest that further EU suggest research of this parties. Implications by third of outside influence variable ternal Taking into states. member in potential exist nuances that societal account into should take expansion as seen because, chasms within those societies exacerbating help in avoiding such nuances can account Creat conflict. international into evolve can then which civil conflict cause such chasms can in Ukraine, the conflict. resolving to is vital in Ukraine and compromise ing consensus The current armed conflict in east Ukraine and the Russian annexation of Crimea are the of Crimea the Russian annexation and Ukraine east in armed conflict The current Abstract: are events February 2014. These in in Ukraine occurred that breakdown the political of results direct move Eu- grow and to continue could struggle that geopolitical a sparked have they because significant the led to factors internal of how nuanced understanding a more Developing Cold War. a new into rope loosely research This conflict. the in addressing taken to be are steps is necessary if realistic breakdown variables which independent of three the interactions explore to approach tracing a process utilizes is a first The aid the approach. data-sets Two review. preliminary literature a through identified were region. The sec- and by oblast organized elections since 1991, presidential of all Ukrainian compilation prime presidents, including elites on select Ukrainian information and career biographical ond contains variables of the domestic that results suggest Preliminary and oligarchs. opposition leaders, ministers, perspectives and policy worldview, Ukrainian identity, well as as arrangements and political institutional ex by the exacerbated were variables domestic These internal for the breakdown. determinative were niversity of Arizona niversity PI: Dr. Political Breakdown in Ukraine: Why it Happened U Arizona Tucson, Zachariah Sean Mills Sean Zachariah Prep UROC UROC PREP 99 - - Patricia Haynes Patricia Currently in the US, one in five individuals suffers from an adult lifetime of clinical anxiety anxiety of clinical from an adult lifetime individuals suffers in the US, one in five Currently Abstract: that reveal will program development of a social-emotional The implementation depression. and/or reduction of adults to the translate setting, in the school will use of mindfulness practice, the practical critical two are and reinforcement consistency However, and depression. anxiety diagnosed with clinical - reinforce and consistency for factors The mediating and adaption. integration long-term for elements role an active have to be willing must outside of the school setting, thus parents be present must ment general gather and assess to intended study is This descriptive of this practice. in the development in mindfulness of their child participating to their acceptance regards in caregivers, of primary attitudes - from school direc authorization site Following six preschools. from drawn were Participants exercises. assigned cubbies. students’ into flyers recruitment distribute permission to granted the author was tors, Paren- survey. online a non-identifying, 20-question complete will 40-80 participants that anticipate We seven-point ten-item, using a their child will be measured for practice of mindfulness acceptability tal statements with or disagree agree they much how to respond in which participants scale, Likert-type ben expected appropriateness, credibility, effectiveness, reasonableness, acceptance, about: suitability, and/or gender caregiver’s the that both anticipate We and justification. level comfort tolerance, efits, collection and analy Final data of acceptability. the level in determining factor a significant will play age 2015. place in fall take sis is to niversity of Arizona niversity ACCESSING PARENTAL ACCEPTABILITY OF MINDFULNESS PRACTICE MINDFULNESS OF ACCEPTABILITY PARENTAL ACCESSING PI: Dr. U Arizona Tucson, William Ned Palmer Ned William Prep UROC UROC PREP 100 - - - - - Marvin J. Slepian J. Marvin Cardiovascular disease is the leading cause of death in the United States and worldwide. The and worldwide. States in the United of death disease is the leading cause Cardiovascular Abstract: a heart transplantation. requires which failure heart congestive disease is of all cardiovascular end stage has been widely used as bridge-to-trans (VAD) device assist a ventricular with donor shortage, However still plague are they systems, VAD success of all the clinical Despite therapy. or as destination plantation methodol (DTE) Emulation Thrombogenicity the Device been using have In our lab we with thrombosis. analysis Device (HSD) as an in vitro and Hemodynamic Shear simulation VAD in silico the optimize ogy to However, VAD. with HeartAssist5 successful has been proven This process assay. state activity of platelet our goal Therefore, operate. specialty to technical and require lab bench equipment and HSD are DTE This mi base assay. i.e. microfluidic Lab on a chip platform into the system miniaturize is to in this study small size, relatively (PDMS), is of polydimethylsiloxane composed of the inexpensive is device crofluidic by devices is operated The microfluidic its operation. for background a technical and does not require stress a shear generating series of loops; passing through are platelets filtered gel where pumps, syringe success- to able be will devices microfluidic the that is hypothesis working Our of HSD. that to equivalent gener configuration; different in three device the microfluidic fabricated have We the HSD. fully replace from the activation the platelet validate we will In the future, of 30, 50, 70 dyne/cm2. stress shear ating HSD. of the activation comparison with the platelet by devices microfluidic niversity of Arizona niversity MICROFLUIDIC DEVICES USED TO REPLICATE THE SHEAR STRESS CALCULATED BY BY CALCULATED STRESS SHEAR THE REPLICATE TO USED DEVICES MICROFLUIDIC VENTRIC OF OPTIMIZATION THE FOR EMULATION THROMBOGENICITY DEVICE THE DEVICES ASSIST ULAR U Arizona Tucson, PI: Dr. Daniel Enrique Enrique Daniel Palomares Prep UROC UROC PREP 101 - Joseph Galaskiewics, Stephen Cornell Galaskiewics,Joseph Stephen The San Xavier Indian Reservation is located in Southern Arizona, just southwest of Tucson. Tucson. of southwest just in Southern Arizona, is located Reservation Indian The San Xavier Abstract: Tohono O’odham is one of the Indian Reservation the San Xavier disconnected, Though geographically Tohono of the as part reservation, Indian San Xavier century, Within the past districts. eleven Nation’s gaming, distribution the casino as such economic endeavors various in participated has Nation, O’odham geographic and economic, political, examine is to of this project The focus and agriculture. of copper, data Qualitative community. in this entrepreneurialism citizen formal and on both informal influences (non- business owners and a sample of nine informal interviews, using semi-structured collected was A total of two public officials. entities), and (taxed owners formal business four private entities), taxed establishment each as well as the number of individuals information, locational establishment’s fifty-five The (GIS) ArcMap. System Information using Geographic and geocoded also recoded was employs, takes place on the northern and economic activity while asserts that of this information combination reservation region of the northwestern in the located establishments of the reservation, border eastern result the region is often activity in this and economic within their social circles, hire to likely more are in Ameri entrepreneurialism of citizen conversation to the study adds This entrepreneurship. of citizen can-Indian communities, and the significance of space when discussing a given community’s economic community’s of space when discussing a given and the significance communities, can-Indian goals. niversity of Arizona niversity SAN XAVIER’S FORMAL AND INFORMAL ECONOMY ECONOMY INFORMAL AND FORMAL XAVIER’S SAN U Arizona Tucson, PI: Drs. Allison L. Ramirez Allison Prep UROC UROC PREP 102 - Laura Lopez Hoffman Lopez Laura its, even if it excludes historical habitat, is the only part of its range that may be considered significant significant be considered may that is the only part of its range habitat, historical if it excludes its, even the species need not be in the world, in abundance elsewhere (2) If a species is present its existence. to range. a portion of its from of it being extirpated risks are there if endangered considered The protection policies put into place by government agencies should meet the needs of should meet agencies government by place put into policies The protection Abstract: is being met species are migratory the needs of endangered on whether species. Data endangered a by be impacted may that as endangered species listed migratory three study We limited. extremely defines (SPOIR) and Portion of its Range” as “Significant to is referred The policy in policy. change recent extinct would become it the species without to a species’ health that so vital area as the ‘significant’ range the species because for migratory particularly problematic be rule may This new everywhere. geographic general to be its considered is for listing the time of determination a species occupies at of the SPOIR the language that the hypothesis evaluate We is overlooked. range while historic range, Because species. endangered for migratory practices impacts on the protection negative policy will have how migratory we investigate species, impacts of SPOIR on migratory the potential predict to want we Service of Fish and Wildlife Our evaluation enacted. SPOIR was before as endangered listed species were inhab a species currently area (1) the assumptions: two makes currently the agency suggest standards niversity of arizona niversity POTENTIAL IMPACTS OF ‘SIGNIFICANT PORTION OF ITS RANGE’ ON MIGRATORY MIGRATORY ON RANGE’ ITS OF PORTION ‘SIGNIFICANT OF IMPACTS POTENTIAL SPECIES U Arizona Tucson, PI: Dr. Mariana S. Rodriguez Rodriguez S. Mariana McGoffin Prep UROC UROC PREP 103 - - Noel Warfel dition to reducing HIF-1 activity, inhibition of PIM kinases reduced cell viability preferentially in hypoxia. in preferentially reduced cell viability inhibition of PIM kinases reducing HIF-1 activity, to dition that AZD1208 indicating rescue cell viability, to failed HIF-1 active of a constitutively Overexpression oxygen reactive AZD1208 increased Interestingly, manner. independent in a HIF-1 induces cell death partially ROS scavengers of Introduction than in normoxia. in hypoxia extent a greater to species (ROS) to the AZD1208 induced cell factor contributing ROS as a implicating cell viability in hypoxia, rescued is selec and HIF-1 levels, inhibition of PIM kinases decrease that indicate the studies Together, death. cells. hypoxic to toxic tively Cancer arises from an accumulation of mutations that result in uncontrolled cell growth. As growth. cell result in uncontrolled that of mutations an accumulation Cancer arises from Abstract: regions hypoxic of results in the emergence which vasculature, the existing cells outgrow a tumor forms, to tissues, and it has been implicated diffusion oxygen as insufficient is defined Hypoxia in solid tumors. that proteins Two of drug resistance. and the development progression, malignant in tumor growth, HIF-1 and PIM kinases. Although PIM are in hypoxia and tumor growth cell survival cancer to contribute hypoxia, in upregulated and are role in tumorigenesis a significant play to been shown kinases have inhibition of PIM that study shows This context. in this evaluated inhibition of PIM kinases has not been HIF-1 in humans, reduces being used is currently that AZD1208, a pan-PIM kinase inhibitor kinases by of the and the presence Domain proteins, Hydroxylase by Prolyl of HIF-1 Hydroxylation levels. protein of HIF-1. In ad degradation AZD1208 mediated necessary for are Hippel-Lindau tumor suppressor von niversity of Arizona niversity PI: Dr. in Hypoxia HIF-1 Activity and Survival PIM Kinase Regulates U Arizona Tucson, Alva Sainz Alva Prep UROC UROC PREP 104 - - -

Rudy Molina Rudy Students who have learning disabilities face a wide array of difficulties that encompass that of difficulties face a wide array learning disabilities have who Students Abstract: of experiences the lived are and bullying. What self-esteem as low such than school assignments, more stu do these specifically, More been diagnosed with a learning disability? who have students college dents experience prejudice or discrimination from sources other than peers? In depth interviews with interviews In depth other than peers? sources from or discrimination prejudice experience dents research-intensive at a large students undergraduate with three conducted were open-ended questions Alterna in their Strategic participants registered who were States United in the southwestern university and interactions, social intervention, Reoccurring themes of identity, Techniques Center. Learning tive by these shared stories and perspectives The with all participants. be significant to found were family to impact fu can be utilized and of learning disabilities knowledge the general to contributes students and treatments. programs new policies and implement ture

niversity of Arizona niversity THE LIVED EXPERIENCE OF COLLEGE STUDENTS WITH LEARNING DISABILITIES LEARNING WITH STUDENTS COLLEGE OF EXPERIENCE LIVED THE

PI: Dr. U Arizona Tucson,

UROC Prep UROC Carlene Ann Swift Ann Carlene UROC PREP 105 - - -

Leila Barraza Recent survey data and alarming news stories indicate that there are growing ethical and le ethical growing are there that indicate stories news and alarming data survey Recent Abstract: topic central A professionals. care by health patients of maternity the treatment regarding concerns gal particularly during labor patients, from obtained consent is the quality of informed these concerns to informed the quality of of the issues influencing perspective a broad develop to In order and delivery. various disci journal articles from of peer-reviewed a variety this project, for care in maternity consent at the hospital. may encounter she interventions and medical delivery, labor, about pregnancy, mation collaborative to use a are advised patients expectant work with who providers care health Additionally, possible. whenever preferences the patient’s which honors care to approach plines were reviewed and analyzed for recurrent themes. Three primary issues emerged as underlying primary issues emerged themes. Three recurrent for and analyzed reviewed plines were common regarding education patient 1) Inadequate consent: quality informed low for determinants and patient between the communication effective to 2) Barriers or procedures, interventions medical health by some maternal tendency A imbalances, and 3) and power constraints including time physician to make physician lead a that as behaviors medicine. This is defined defensive practice to providers care and comfortable legally provider(s) care the makes based on what the patient choices for health care of these issues, a occurrences future minimize or need. To want mother may the expectant less on what is proposed education A model of prenatal professionals. health care by be taken may number of steps infor important to learn room as an opportunity waiting spends in the patient time the utilizes that

niversity of Arizona niversity ASSESSING THE QUALITY OF INFORMED CONSENT IN THE AMERICAN MATERNITY MATERNITY AMERICAN THE IN CONSENT INFORMED OF QUALITY THE ASSESSING SYSTEM CARE

PI: Dr. U Arizona Tucson,

UROC Prep UROC Meighan N. Taylor N. Meighan UROC PREP 106 -

Mary A. Irwin Mary - de and are States the United around universities many at exist programs Summer bridge Abstract: & (Hoops college to high school from in their transition and assist college for students prepare signed to students comparing and skill development preparedness academic examines 2015). This study Kutryala, at program summer bridge during a six-week campus to who commute students to on campus who live includes a combination This study States. of the United region in the southwest university a four-year that included demographic two surveys completed Students analysis. and quantitative of qualitative student/faculty and habits, social interactions; on academic focused responses scaled Likert background; con- The sample program. experience in the student’s regarding and open-ended questions interaction, students female or male. 204 as who did not identify 106 males, and 2 students of 192 females, sisted 60% of the popula students, campus. Out of the 300 off live hall and 96 students in the resident reside Fall 2015. revealed in Latino(a). Findings will be as Hispanic or tion identify

niversity of Arizona niversity AN INVESTIGATION INTO THE NEW START SUMMER PROGRAM: SUMMER START NEW THE INTO INVESTIGATION AN PROGRAM BRIDGE MENTORSHIP-BASED PEER A

PI: Dr. U Arizona Tucson,

UROC Prep UROC Jasmine Tuynae Wilson Tuynae Jasmine UROC PREP 107 PROGRAM STAFF AND SPONSORS • 2015

SUMMER RESEARCH INSTITUTE (SRI) Funding for this research was provided by the NSF Engineer- Coordinator: Donna Treloar, MA ing Research Center No. EEC-0812072. Instructors: Andrew Huerta, PhD, Renee Reynolds, ABD, Joanna Sanchez-Avila BIOSPHERE 2 Sponsors: University of Arizona; Graduate College; The PI: Katerina Dontsova, PhD Partnership for Native American Cancer Prevention (NACP) Sponsors: National Science Foundation Research Experiences training program, a collaboration between Northern Arizo- for Undergraduates Program. na University and the University of Arizona Cancer Center, funded by the National Cancer Institute; College of Medicine STUDENT AFFAIRS RESEARCH PROGRAM (STAR) – Office of Diversity and Inclusion, Health Resources and Ser- Coordinator: Nura Dualeh, MA vices Administration (HRSA) Centers of Excellence; Western Instructors: Andrew Huerta, PhD, Renee Reynolds, MA, Joanna Alliance to Expand Student Opportunities (WAESO); Depart- Sanchez-Avila ment of Physics. Sponsors: University of Arizona; Graduate College; Division of Student Affairs; Western Alliance to Expand Student Opportu- MINORITY HEALTH DISPARITIES SUMMER RESEARCH nities (WAESO). PROGRAM (MHD) Coordinator: Stephanie Adamson, Holly Lopez UROC-PREP Sponsors: University of Arizona; Graduate College; Western Coordinator: Donna Treloar, MA Alliance to Expand Student Opportunities (WAESO). Instructor: Andrew Huerta, PhD Sponsors: University of Arizona; Graduate College, Western MAXIMIZING ACCESS TO RESEARCH CAREERS (MARC) Alliance to Expand Student Opportunities (WAESO). PIs: Megan McEvoy, PhD; Marc Tischler, PhD, Maria Teresa Velez; PhD CAT VEHICLE PROGRAM/ ECE REU Coordinator: Cindy Neal, MEd PI: Jonathan Sprinkle, PhD Sponsor: NIGMS/TWD Division GM 08718 Coordinator: Nancy Emptage Sponsor: National Science Foundation Research Experiences HOOKED ON PHOTONICS RESEARCH EXPERIENCE FOR for Undergraduates Program UNDERGRADUATES (HOP) PIs: Nasser Peyghambarian, PhD RESEARCH IN OPTICS (RiO) Sponsors: University of Washington/National Science Foun- PI: R. John Koshel, PhD dation (NSF). Funding for this research was provided by NSF Coordinator: Melissa Sarmiento Ayala, MEd Grant No. CHE-1156598. Sponsor: National Science Foundation (NSF) Award No. 1460723. CIAN INTEGRATED OPTICS FOR UNDERGRADUATE NATIVE AMERICANS (IOU-NA) RESEARCH EXPERIENCE FOR UNDERGRADUATES PI: Allison Huff Mac Pherson, DHEd, Robert Norwood, PhD Coordinator: Ameé J. Hennig, Daniel Lamoreaux Sponsors: National Science Foundation (NSF) Engineering Research Center for Integrated Access Networks (ERC CIAN).

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