US 20060276339A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0276339 A1 Windsor et al. (43) Pub. Date: Dec. 7, 2006

(54) METHODS AND COMPOSITIONS FOR Publication Classification INCREASING THE EFFICACY OF BOLOGICALLY ACTIVE INGREDIENTS (51) Int. Cl. AOIN 57/00 (2006.01) A6II 3L/43 (2006.01) A6II 3/545 (2006.01) (76) Inventors: J. Brian Windsor, Austin, TX (US); A6II 3/425 (2006.01) Stan J. Roux, Austin, TX (US); Alan A6II 3/405 (2006.01) M. Lloyd, Austin, TX (US); Collin E. A6II 3 L/65 (2006.01) Thomas, Dallas, TX (US) AOIN 43/16 (2006.01) AOIN 47/06 (2006.01) A6II 3L/235 (2006.01) Correspondence Address: A6II 3L/24 (2006.01) FULBRIGHT & UAWORSK LLP. A6II 3/18 (2006.01) 6OO CONGRESS AVE. A6II 3/426 (2006.01) SUTE 24 OO (52) U.S. Cl...... 504/127: 504/128: 514/192: AUSTIN, TX 78701 (US) 514/200: 514/370; 514/602; 514/.414: 514/617; 514/615; 514/532: 514/616; 514/535: (21) Appl. No.: 10/531,744 514/.457; 514/443; 514/369; 514/533: 514/512 (22) PCT Filed: Oct. 16, 2003 (57) ABSTRACT The invention provides methods and compositions for modulating the sensitivity of cells to cytotoxic compounds (86). PCT No.: PCT/USO3/32667 and other active agents. In accordance with the invention, compositions are provided comprising combinations of ectophosphatase inhibitors and active agents. Active agents Related U.S. Application Data include antibiotics, fungicides, herbicides, insecticides, che motherapeutic agents, and plant growth regulators. By increasing the efficacy of active agents, the invention allows (60) Provisional application No. 60/418,803, filed on Oct. use of compositions with lowered concentrations of active 16, 2002. ingredients. Patent Application Publication Dec. 7, 2006 Sheet 1 of 13 US 2006/0276339 A1

FIG. A

Wt 35SpsNTP935SpsNTP935SpsNTP9 OE1 OE2 0E3

s 0.1 FIG. 1 C

0 s Wt 35SpsNTP Patent Application Publication Dec. 7, 2006 Sheet 2 of 13 US 2006/0276339 A1 3HATPUptake 4000

S 2000 FIG. 2A

0 w Wt 35S/psNTP9 alpha 32P ATPUptake 4000

S 2000 FIG. 2B

0 r Wt 35S/psNTP9

gamma 32PATPUptake 150000

100000 S S. FIG. 2C CD Ne 1nM COLD 50000 N ATPADDED wn assistpg Patent Application Publication Dec. 7, 2006 Sheet 3 of 13 US 2006/0276339 A1 Phosphatatse Wild Type knOCked Out

Not expreSSingatpgp FIG. 3A

eXpreSSingalpgp FIG. 3B

No Drug Nigericin sii has Patent Applica ion Publi Ca tion Dec. 7 9 2006 Sheet 4 of 13 US 2006/0276339 A1

Patent Application Publication Dec. 7, 2006 Sheet 5 of 13 US 2006/0276339 A1

Patent Application Publication Dec. 7, 2006 Sheet 6 of 13 US 2006/0276339 A1

1.5

1. 0 - +atpgp ------, mOCk transformant 0. 5

0.0 0 20 40 60 t(h) FIG. 5A

- YMR4 MDR1 a YMR4pwt - IWWSCMDR1 ---. INWSCp Patent Application Publication Dec. 7, 2006 Sheet 7 of 13 US 2006/0276339 A1

80 70 60 50 40 30 20 10 0 Wit atpgp OE ApyraSe OE FIG. 6

-V-MDR1/+GLUCOSE -O-MOCK/+GLUCOSE --MDR1/-GLUCOSE S -0-MOCK/-GLUCOSE Patent Application Publication Dec. 7, 2006 Sheet 8 of 13 US 2006/0276339 A1

f 0

5

0 IOCk MDR1 OCk MDR1 is 17 n=29 = 17 n=29 p<0.06 pC0.05 + glucose -glucose FIG. 8

80. -o- YMR4?atpgp1 6 O -A- YMR4/OVt101

4. O S Patent Application Publication Dec. 7, 2006 Sheet 9 of 13 US 2006/0276339 A1

Patent Application Publication Dec. 7, 2006 Sheet 10 of 13 US 2006/0276339 A1

200 180 160 S 140 S S 120 NS 100 S 80 N S. 60 40 20 0 IMDR1 IMDR1 M/ (line 4) (line 2) FIG. 11 Patent Application Publication Dec. 7, 2006 Sheet 11 of 13 US 2006/0276339 A1

3puffe:?su?),OM/

Patent Application Publication Dec. 7, 2006 Sheet 12 of 13 US 2006/0276339 A1

Drug selected Cells Cells Cultured only on Media Cycloheximide ym4mdr1 0.754 0.014 ymrapvt 0.017 0.016 in VSCmdr1 0.683 0.013 in VSCpWt 0.985 0.005 ATP+cycloheximide ym4mdr1 0.001 0.001 ymrapvt 0.002 0.001 iny SCmdr1 0.001 0.002 in VSC pyt 0.001 0.002 ATP ym4mdr1 0.016 0.585 ymrapvt 0.001 0.697 iny scmdr1 0.271 1.267 inv Scpwt 0.052 0.213 Media alone ym4mdr1 1.477 1.478 ymr1pvt 1.437 1484 inWSCmdr1 1.498 1483 inv SC pyt 1488 1.435

FIG. 13 Patent Application Publication Dec. 7, 2006 Sheet 13 of 13 US 2006/0276339 A1

Media alone Cycloheximide ymrmdr1 1.376 ymr midr1 0.937 ymrapVt 1.429 ymrapwt 0.001

P04 alone PQ and Cycloheximide ymr mdr1 1.351 ymr mdr1 0.541 ymrapvt 1.341 ymr4 pvt 0.001

Aden0Sine alone Adenosine and Cyclohexinide ymr mor1 1.319 ymrmdr1 0.632 ymrapVt 1.354 ymr4 pvt 0.002

Adenoside and P04 alone Adenoside and P0 and Cycloheximide ymr mdr1 0.899 ymr mdr1 0.389 ymrapVt 1.342 ymra pvt 0.001

FIG, 14 US 2006/0276339 A1 Dec. 7, 2006

METHODS AND COMPOSITIONS FOR four genes will code for them, depending on whether both INCREASING THE EFFICACY OF are homodimers, one is a homodimer and one is a het BOLOGICALLY ACTIVE INGREDIENTS erodimer, or both are heterodimers, respectively. The best characterized of the eukaryotic proteins included in this BACKGROUND OF THE INVENTION family are the multidrug-resistance (MDR) transporter and the cystic fibrosis related chloride ion channel of mamma 0001) 1. Field of the Invention lian cells (cystic fibrosis transmembrane conductance regu 0002 The present invention relates generally to the fields lator or CFTR) (Meyers, 1997). of cellular biology. More particularly, it concerns methods Multidrug Resistance and compositions for the modulation of cellular sensitivity to biologically-active agents. 0008 Multidrug resistance (MDR) is a general term that refers to the phenotype of cells or microorganisms that 0003 2. Description of Related Art exhibit resistance to different, chemically dissimilar, cyto toxic compounds. MDR can develop after sequential or Transport Processes simultaneous exposure to various drugs. MDR can also 0004 Cells can use a phenomenon called symport to develop before exposure to many compounds to which a cell move soluble products across biological membranes. Sym or microorganism may be found to be resistant. MDR which port is a form of coupled movement of two solutes in the develops before exposure is frequently due to a genetic same direction across a membrane by a single carrier. event which causes the altered expression and/or mutation of Examples of proton and Sodium-linked symport systems are an ATP-binding cassette (ABC) transporter (Wadkins and found in nearly all living systems. The energetics of the Roepe, 1997). This is true for both eukaryotes and prokary transport event depend on the relative size and electrical OteS. nature of the gradient of Solutes. 0009. One prominent member of the ABC family, P-gly 0005 Transport processes have been classified on the coprotein (Pgp; also known as multidrug resistance protein basis of their energy-coupling mechanisms. Currently there or MDR1), which is a plasma-membrane glycoprotein that are four classifications: (1) Primary Active Transport which confers a multidrug resistance (MDR) phenotype on cells, is uses either a chemical, light or electrical energy source, (2) of considerable interest because it provides one mechanism Group Translocation which uses chemical energy sources, of possibly inhibiting resistance in tumor cells to chemo (3) Secondary Active Transport which uses either a sodium therapeutic agents (Senior et al., 1995). Pgp is a single or proton electrochemical gradient energy source, and (4) polypeptide of ~1280 amino acids with the typical ABC Facilitated Diffusion which does not require an energy transporter structure profile. Studies have shown that over source (Meyers, 1997). The present invention is related to expression of Pgp is responsible for the ATP-dependent transport molecules belonging to the first class of transport extrusion of a variety of compounds, including chemothera processes, primary active transport, and therefore, this type peutic drugs, from cells (Abraham et al., 1993). of transport will be discussed in further detail. 0010. Over one-hundred ABC transporters have been 0006 Primary active transport refers to a process identified in species ranging from Escherichia coli to whereby a “primary' source of energy is used to drive the humans (Higgins, 1995). For example, the bacteria Lacto active accumulation of a solute into or extrusion of a solute coccus lactis expresses an ABC transporter, Limra, which from a cell. Transport proteins include P-type ATPases and mediates antibiotic resistance by extruding amphiphilic ABC-type ATPases, as well as V-type and E-type ATPases. compounds from the inner leaflet of the cytoplasmic mem These types of transport systems are found in both eukary brane (Van Veen et al., 1998). Furthermore, over-expression otes and prokaryotes. The bacterial ABC-type transporters, of Limr A can confer MDR in human lung fibroblasts and which are ATP-driven solute pumps, have eukaryotic coun Limra has similar molecular and biochemical properties to terparts. Additionally, many transmembrane Solute transport Pgp. This demonstrates that bacterial Limr A and Pgp are proteins exhibit a common structural motif. The proteins in functionally interchangeable. Additionally, the plant Arabi these families consist of units or domains that pass through dopsis thaliana encodes an ATP transporter, AtPGP-1, which the membrane six times, each time as an O-helix. This has is a putative Pgp homolog (Dudler and Hertig, 1992). led to the Suggestion that many transport proteins share a Similarly, the yeast Saccharomyces cerevisiae equivalent of common evolutionary origin, but this is not true of several Pgp, STS 1 (Bissinger and Kucher, 1994) has been cloned distinct families of transport proteins. and shown to confer multidrug resistance when over-ex 0007 Numerous structurally distinct bacterial permeases, pressed in yeast, as has the yeast Pdr5p (Kolacskowski et al., as well as several homologous eukaryotic transport systems, 1996). Taken together, these results suggest, that this type of share a common organization (Meyers, 1997). Two hydro multidrug resistance efflux pump is conserved from bacteria philic domains or proteins function to couple ATP hydrolysis to humans. in the cytoplasm to activate Substrate uptake or efflux, and 0011 While various theories of ABC transporter function two hydrophobic domains or proteins function as the trans have become popular, there is still no precise molecular membrane Substrate channels. These proteins or protein level description for the mechanism by which over-expres domains constitute what is referred to as the ABC (ATP sion lowers intracellular accumulation of drugs, in particular binding cassette) superfamily. Either the two hydrophilic how Pgp lowers intracellular accumulation of chemothera domains or proteins or the two hydrophobic domains or peutic drugs. However, it has been shown that Pgp over proteins (or both) may exist either as heterodimers or expression also changes plasma membrane electrical poten homodimers. If, as in most bacterial systems, each of these tial and intracellular pH which could potentially greatly constituents is a distinct protein, then either two, three, or affect the cellular flux of a large number of compounds to US 2006/0276339 A1 Dec. 7, 2006

which Pgp confers resistance (Wadkins and Roepe, 1997). nism by which the cell circumvents the loss of ATP (due to Also included in the ABC transporter superfamily are the up-regulated transport proteins which possibly form ATP Cystic Fibrosis Transmembrane Conductance Regulator transport channels) by creating higher levels of adenosine (CFTR) and the Sulfonyl Urea Receptor (SUR). CFTR and from which the cell can produce ATP. Correspondingly, 63% SUR are expressed in the lung epithelium and the B cells of of MDR cell line variants tested expressed ecto-5'-nucleoti the pancreas, respectively, as well as in other tissues. CFTR dase. These observations suggested that a salvage mecha functions as a low conductance ATP and cyclic AMP nism for extracellular nucleotides may be another way by dependent Clchannel that also appears to have additional which certain MDR cells counterbalance their ATP losses important functions, such as modulation of epithelial from efflux induced by the over-expression of ABC trans NA"regulation of outwardly rectified chloride channels porters involved in MMR. Consistent with this hypothesis, (Wadkins and Roepe, 1997). inhibitors of ecto-5'-nucleotidase conferred sensitivity to certain drugs in MDR cell lines which over-express the 0012 Mutations in the CFTR gene produce altered CFTR ecto-5'-nucleotidase. proteins with defects in CFTR function, leading to profound alterations in epithelial salt transport and altered mucous 0016. It is also interesting to note that yeast, which do not properties in cystic fibrosis patients that result in chronic have an adenosine salvage pathway (Boyum and Guidotti, lung infections associated with the disease. Id. SUR is 1997), do contain a PGP-like gene called STS 1 (Bissinger triggered by Sulfonyl urea drugs to depolarize pancreatic P and Kucher, 1994). Therefore, since the adenosine salvage cells that leads to Ca"influx, which stimulates fusion of pathway is unlikely to be involved in yeast multidrug insulin containing vesicles to the plasma membrane. Id. An resistance, other mechanisms are likely to exist. ATP transporter hypothesis has been Suggested for Pgp, CFTR and SUR which theorizes that these ABC transporters 0017 Recent reports have confirmed the existence of function as ATP transport channels (Abraham et al., 1993; ATP in the extracellular matrix (ECM) of both multicellular Schweibert, 1995; Al-Awgati, 1995). The ATP channel organisms and unicellular organisms (Sedaa et al., 1990; hypothesis, however, has been viewed with skepticism. This Boyum and Guidotti, 1997), respectively. However, no such is partly due to the inability to show the same results with reports are available which suggest the existence of ATP in preparations including purified and reconstituted CFTR, the ECM of plants before the present invention. These Suggesting that the ATP conductance that was originally reports have prompted further investigations of the fate of observed may have been mediated by another protein, not ATP outside the cell. One of the largest gradients in bio present in the purified system, that is influenced by CFTR logical systems is that of ATP. It is a million-fold more (Wadkins and Roepe). There has been no such negative data concentrated inside the cell than outside. Phosphatases are reported with respect to the ATP charnel hypothesis for Pgp enzymes with the ability to hydrolyze ATP and to a lesser extent, the beta phosphate of ADP (Plesner, 1995). Extra or SUR, but the controversy over CFTR has raised doubt for cellular phosphatases are generally referred to as ectophos Pgp and SUR as well. phatases A type of ectophosphatase is ecto-pyrase. Given 0013 In support of the ATP channel hypothesis (Huang et reports that show the existence of extracellular ATP, one al., 1992) have suggested that extracellular ATP leads to observation regarding ectoapyrase is that it hydrolyzes the elevations in pH, and Weiner et al., (1986) have suggested extracellular ATP. In fact, work in animal systems has shown that extracellular ATP may regulate Na/H"exchange in that apyrases hydrolyze ATP in the ECM as part of the Ehrlich ascites tumor cells. It has also been observed that adenosine Salvage pathway conjointly with ecto-5' ecto changes in Pgp levels affects pH and plasma membrane nucleotidase (Che, 1992). electrical potentials which could be connected to recent 0018 What has been lacking in the art are particular observations suggesting the involvement of ATP transport in methods and compositions that allow modification of cel MDR. lular ATP gradients to increase the uptake of cytotoxic 0014) Additionally, Abraham et al., (1993) have reported agents by cells. It would be particularly useful to identify that the addition of extracellular ATP to MDR cell lines methods and compositions that result in increased uptake by confers sensitivity to drugs abolishing MDR. The data for cells of herbicides, antibiotics, fungicides, insecticides, che this effect were not presented in the article and no further motherapeutics and other active ingredients. This may result explanation was given for this phenomenon. Furthermore, in increased efficacy in the use of Such agents, as well as there have been no Subsequent publications addressing or allow use of lower concentrations of Such agents. This may explaining this effect. provide cost, health and environmental benefits. This may also allow effective treatment of MDR cells, such as anti 0015. Furthermore, Ujhazy et al., (1996) have shown that biotic-resistant bacteria or chemotherapy-resistant tumor ecto-5'-nucleotidase is up-regulated in certain MDR cell cells. lines. Ecto-5'-nucleotidase is the final enzyme in the extra cellular pathway for salvage of adenosine from phosphory SUMMARY OF THE INVENTION lated purines (Zimmerman, 1992). The proposed hypothesis for the involvement of ecto-5'-nucleotidase in drug resis 0019. In one aspect, the invention provides a cytotoxic tance considers its role in the maintenance of intracellular composition comprising an ectophosphatase inhibitor and a ATP pools through the adenosine Salvage pathway (Ulhazy cytotoxic agent set forth in Table 1. In one embodiment of et al., 1996). Ecto-5'-nucleotidase specifically acts in the invention, the cytotoxic agent is selectively cytotoxic. In adenosine salvage pathways, converting AMP to adenosine other embodiments, the cytotoxic composition may be fur which is more readily taken up by the cell and utilized as a ther defined as a herbicidal composition and the cytotoxic precursor for ATP production. Therefore, ecto-5'-nucleoti agent a herbicide, may be further defined as an insecticidal dase may be acting in certain MDR cell lines as a mecha composition and the cytotoxic agent an insecticide, may be US 2006/0276339 A1 Dec. 7, 2006

further defined as a fungicidal composition and the cytotoxic BRIEF DESCRIPTION OF THE DRAWINGS agent a fungicide and/or may be further defined as an 0026. The following drawings form part of the present antibiotic composition and the cytotoxic agent an antibiotic. specification and are included to further demonstrate certain In an antibiotic composition, the antibiotic may be from a aspects of the present invention. The invention may be better class selected from the group consisting of Beta-lactam, understood by reference to one or more of these drawings in Semisynthetic penicillin, Clavulanic Acid, Monobactams, combination with the detailed description of specific Carboxypenems, Aminoglycosides, Glycopeptides, Linco embodiments presented herein. mycins, Macrollides, Polyenes, Rifamycins, Tetracyclines, Semisynthetic, tetracycline and Chloramphenicol. In certain 0027 FIGS. 1A-1C Expression of apyrase in pea and in embodiments of the invention, the ectophosphatase inhibitor transgenic plants (FIG. 1A) Immunoblot analysis of sub may be selected from the group consisting of the compounds cellular fractions from etiolated pea plants. (FIG. 1B) Top, of formulae I-XX. the total phosphate accumulated in the shoots of three independent transgenic plants. Bottom, a corresponding 0020. In another aspect, the invention provides a plant Immunoblot performed on protein from ECM of wild-type growth regulator composition comprising an ectophos and transgenic plants. (FIG. 1C) Assay of phosphatase phatase inhibitor and a plant growth regulator agent set forth activity in the ECM fraction of OE1 and wild-type. in Table 1. In one embodiment of the invention, the ecto 0028 FIGS. 2A-C Transport of the products of ATP phosphatase inhibitor is selected from the group consisting hydrolysis by transgenic plants overexpressing apyrase and of the compounds of formulae I-XX. by wild-type plants. 0021. In yet another aspect, the invention provides a 0029 FIGS. 3A-D Conference of resistance to cyclohex chemotherapeutic composition comprising an ectophos imide (FIG. 3A, B) and nigencin (FIG. 3C, D) in wild-type phatase inhibitory compound and a chemotherapeutic agent. and ectophosphatase deficient yeast over-expressing the In one embodiment of the invention, the chemotherapeutic agent is a chemotherapeutic agent set forth in Table 3. In Arabidopsis plant ABC transporter, AtPGP-1. further embodiments of the invention, the ectophosphatase 0030 FIGS. 4A-B-3 Conference of resistance to cyclo inhibitor is selected from the group consisting of the com heximide (FIG. 4A) and cytokinin (FIG. 4B-1-FIG. 4B-3) pounds of formulae I-XX. in Arabidopsis plants over-expressing either the ectophos phatase, apyrase, or the ABC transporter, AtPGP-1. 0022. In still yet another aspect, the invention provides a method of killing or inhibiting the growth of a plant, 0031 FIGS.5A-B Graph showing the growth turbidity of comprising contacting said plant with an effective amount of YMR4 yeast over-expressing the Arabidopsis plant ABC a herbicidal composition provided by the invention. The transporter AtPGP-1 grown in cycloheximide (FIG. 5A) or method may be carried out with potentially any plant, nigericin (FIG. 5B). including a monocotyledonous plant or a dicotyledonous 0032 FIG. 6 Graph showing germination rate of Arabi plant. dopsis plants grown in the presence of cycloheximide which 0023. In still yet another aspect, the invention provides a over-express either the ectophosphatase, apyrase, or the method of killing or inhibiting the growth of a tumor cell, ABC transporter AtPGP-1. comprising contacting said tumor cell with an effective 0033 FIG. 7 Graph of steady-state levels of ATP in the amount of a chemotherapeutic composition of the invention. extracellular fluid of wildtype yeast cells grown in the In the method, contacting may comprise administering the presence or absence of glucose and in the presence or composition to a patient in need thereof, wherein the patient absence of over-expression of the Arabidopsis plant ABC comprises the tumor cell. transporter, AtPGP-1. 0024. In still yet another aspect, the invention provides a 0034 FIG. 8 Graph showing that over-expression of method of killing or inhibiting the growth of a target cell, Arabidopsis plant ABC transporter. AtPGP-1, in yeast can comprising contacting said cell with a composition formu double the steady-state levels of ATP in the extracellular lated therefore. In certain embodiments of the invention, the fluid. cell may be a fungal cell, bacterial cell, or insect cell. 0035 FIG.9 Graph showing that a yeast mutant, YMR4, 0025. In still yet another aspect, the invention provides a that has a deficient ectophosphatase, accumulates ATP in the method of increasing the effectiveness of a cytotoxic agent, extracellular fluid and the over-expression of AtPGP-1 comprising admixing said cytotoxic agent with an ectophos increases the accumulation of ATP. phatase inhibitor, wherein the cytotoxic agent is selected 0036 FIG. 10 Graph showing results of a pulse-chase from the group set forth in Table 1. In certain embodiments experiment in either wildtype yeast cells or a yeast mutant, of the invention, the cytotoxic agent may be further defined YMR4, which is deficient in ectophosphatase activity, in the as a herbicide, insecticide, fungicide, and an antibiotic. presence and absence of over-expression of Arabidopsis Examples of antibiotics include those from the following plant ABC transporter. AtPGP-1, demonstrating an early classes: Beta-lactam, Semisynthetic penicillin, Clavulanic differential ATP efflux of cells over-expressing AtPGP-1. Acid, Monobactams, Carboxypenems, Aminoglycosides, Glycopeptides, Lincomycins, Macrollides, Polyenes, Rifa 0037 FIG. 11 Graph of ATP levels on the surface of mycins, Tetracyclines, Semisynthetic, tetracycline and leaves of Arabidopsis plants over-expressing AtPGP-1 Chloramphenicol. In one embodiment of the invention. In (MDR 1). one embodiment of the invention, a cytotoxic agent is a 0038 FIG. 12 Effects of phosphatase inhibitor in wild chemotherapeutic agent, for example, selected from the type and AtPGP-1 (MDRI) overexpressing Arabidopsis group set forth in Table 3. plants. US 2006/0276339 A1 Dec. 7, 2006

0039 FIG. 13 Growth effects of cycloheximide and with cytotoxic agents, including herbicides, antibiotics, fun extracellular ATP on wildtype and MDR1 overexpressing S. gicides, insecticides and other active ingredients, as well as cerevisiae yeast cells which have either never seen cyclo chemotherapeutics. By “contemporaneously, it is meant heximide or which have been previously selected in cyclo within Sufficient temporal proximity that the increased sen heximide. sitivity of a cell to the relevant cytotoxic agent may be achieved in combination with contacting the cell with the 0040 FIG. 14 Growth effects of cycloheximide, adenos agent. In certain embodiments of the invention, ectophos ine and phosphate on wildtype and AtPGP-1 overexpressing phatase inhibitors are used as adjuvants with cytotoxic S. cerevisiae yeast cells. agents, that is, are admixed with one or more cytotoxic DETAILED DESCRIPTION OF THE agents or other active ingredients. INVENTION 0045. It is thereforean, object of the present invention to 0041. The present invention provides methods and com provide inhibitors of ectophosphatases in physiological positions for modulating the sensitivity of cells to cytotoxic compositions for modulating cell growth and/or Survival, compounds and other active agents. In accordance with the including, but not limited to, MDR cells. Such physiological invention, Such modulation may be carried out by modifying compositions may comprise a small molecule capable of cellular ATP gradients, for example, by contacting a plant, inhibiting an ectophosphatase and a physiologically accept animal, yeast or bacterial cell with an ectophosphatase able carrier or diluent together with a therapeutic agent. As inhibitor contemporaneously with a cytotoxic agent or other used herein, the term "physiologically acceptable carrier or active ingredient, or combinations thereof. As used herein, diluent’ means any and all solvents, dispersion media, the term “ectophosphatase inhibitor” refers to a compound antibacterial and antifungal agents, microcapsules, lipo that has the ability to specifically inhibit ectophosphatase Somes, cationic lipid carriers, isotonic and absorption delay activity. A “cytotoxic agent' is a compound capable of ing agents and the like which are not incompatible with the selectively or non-selectively killing or inhibiting the growth ectophosphatase inhibitors. The use of Such media and agents for physiologically active substances is well known of a cell, including antibiotics, fungicides, herbicides, insec in the art. Supplementary active ingredients may also be ticides and chemotherapeutic agents. incorporated into the compositions. 0042. The efficacy of one or more cytotoxic agents may be increased in accordance with the invention by reducing 0046. In certain embodiments, only an endogenous ecto the ATP gradient across biological membranes, which is phosphatase is inhibited. In particular embodiments of the effectuated through the modulation of an ectophosphatase invention, the ectophosphatase is human apyrase. In other either alone or together with an ABC transporter molecule. embodiments, the ectophosphatase is a plant, bacterial, Modulation of resistance to a cytotoxic compound as fungal or yeast ectophosphatase. described herein is useful, for example, in increasing the sensitivity of plants to herbicides; reducing drug resistance 0047 The inhibition of ectophosphatases is useful in in tumor cells for improved chemotherapy applications; and increasing sensitivity to cytotoxic agents and/or reduction of reducing resistance to antibiotics, antifungal agents, insec drug resistance in cells. In one embodiment of the invention, ticides and other cytotoxic agents for the treatment of the inhibition of ectophosphatases results in a loss of resis infections and disease. Provided by the invention are spe tance to a cytotoxic agent. In another embodiment of the cific combinations of ectophosphatase inhibitors and cyto invention, administration of Such inhibitory molecules is in toxic compounds or other active ingredients that may be conjunction with the administration of chemotherapeutic used in these applications. agents in tumor cells. 0043. In accordance with certain embodiments of the 0048. Using high throughput screens, ectophosphatase invention, the manipulation of extracellular ATP levels to inhibitors may be isolated, for example, by Screening a small alter ATP gradient across biological membranes in cells by molecule library (e.g. a combinatorial library) for inhibitory inhibition of ectophosphatases results in diminishing or activity to ectophosphatase (e.g. apyrase activity). Once removing the ATP gradient that may otherwise prevent ectophosphatase inhibitory molecules are isolated from Such access of cytotoxic agents to the cell. In some instances, a screen, the inhibitors may be further tested for their ability access may be minimized by efflux of cytotoxic agents from to specifically inhibit the ATPase activity of the ectophos the cell. This efflux is likely effectuated through the "piggy phatase. back' efflux of drug molecules with ATP, a phenomenon 0049 Exemplary ectophosphatase inhibitory molecules known as Symport. for use with the current invention are preferably chemically 0044) In accordance with the invention, inhibitors of stable and physiologically active including, but not limited ectophosphatases may be administered contemporaneously to, the compounds of formulae I-XX.

Formula I Formula II

O S N1 N11 Oc n o KBr ( / N US 2006/0276339 A1 Dec. 7, 2006

-continued Formula III Formula IV C

// \ C C C Formula V Formula VI O O

S / NHV O NS NH

HO

Formula VII Formula VIII O ( ) HN N O NS

Br Formula IX Formula X O O \ N-NH C O O O

Formula XI Formula XII O Nuo O C N O

O NH N

H

Formula XIII Formula XIV

S 1N1N1N1 US 2006/0276339 A1 Dec. 7, 2006

-continued Formula XV Formula XVI OH

O O O

| NH O N- --~~ N N H \ S O H

Formula XVII Formula XVIII S H

o V-N SYN N O ICl. O O S N1 YN N V O l H O B o1 r O-N+ \,M

Formula XIX

H

N

O S. s O

Formula XX OS SO O O

N H3C H -- -- OS SO. Na CH Na OS SO O NH HN O 1s,O H H

0050 Preliminary pharmacophore studies revealed that molecules of the present invention (Medina et al. 1998: the small molecules represented by Formulae I through XX Dhamant et al., 1992). The molecules described by Medina fall into five classes of compounds (sulfanamides, et al. have been shown to affect MDR and the mode of action guanidines, aminothiazoles, thioketones and benzamides). of the molecules is believed to involve tubulin interactions. Most of these chemical classes are found in other physi The thiazine derivatives described by Dhamant et al. reverse ologically-active compounds, including those having phar the resistance in tumor cells to Vincristine. maceutical and therapeutic use. For example, Sulfanimides 0051. The ectophosphatase inhibitory molecules are use are widely used as antibiotics. Additionally, studies for the ful in increasing the activities of various agents by increas isolation of small molecules capable of reversing MDR have ing the availability of the agents to cells. In certain embodi described molecules belonging to two of the classes of ments of the invention, this may comprise reversing US 2006/0276339 A1 Dec. 7, 2006

multidrug resistance (MDR) in an organism. In other I. Formulations embodiments, this may be achieved with a cell that does not exhibit MDR. Such cells may or may not comprise an 0058 Ectophosphatase inhibitor compositions, which up-regulated ectophosphatase may be acidic or basic in nature, can form a wide variety of salts with various inorganic and organic bases or acids, 0.052 MDR reversal and/or increasing of sensitivity to a respectively. These salts may be physiologically acceptable cytotoxic agent in cells may be shown by growing the cells for in vivo administration in mammals, including humans, as in the presence of relevant drugs and in the presence and well as formulations for ex vivo applications, including absence of the inhibitor. Cells which cannot grow in the agricultural use. Salts of acidic compounds are readily presence of a drug in the presence of an ectophosphatase prepared by treating the acidic compound with an appropri inhibitor, have a reversal in MDR and/or increase in sensi ate molar quantity of the chosen inorganic or organic base in tivity to the agent. an aqueous or Suitable organic solvent and then evaporating the solvent to obtain the salt. Salts of basic compounds can 0053. The ectophosphatase inhibitory compositions of be obtained similarly by treatment with the desired inorganic the present invention are useful in reversing drug resistance or organic acid and Subsequent solvent evaporation and in mammalian cell lines grown in the presence of a drug (e.g. a chemotherapeutic agent). Analysis of sensitivity to a isolation. The skilled artisan can produce salts of ectophos chemotherapeutic composition in mammalian cells may be phatase inhibitors using techniques known in the art. shown, for example, by using the fluorescent compound 0059. The skilled artisan readily can determine the calcein-AM. Esterases present in cells cleave the aceto amount of the ectophosphatase inhibitor that is required to methoxy ester (AM) from the calcein-AM and liberate inhibit ectophosphatase by measuring ATPase activity in the calcein. Calcein is a fluorescent compound which is excit presence and absence of varying amounts of the inhibitor. able by the 488 nm laser of a FACS Caliber flow cytometer Phosphatase activity can be determined by assessing the (Becton Dickenson, Franklin Lakes, N.J.), while the dephosphorylation of ATP and liberation of phosphate as uncleaved calcein-AM is not excitable. Wild type cells described herein. Additionally, parameters may be measured incubated in the presence of calcein-AM show a high level that are known to be associated with ectophosphatase activ of fluorescence while MDR state cells, which efflux the ity to determine whether the molecule has ectophosphatase calcein-AM faster than the cellular esterases can cleave it, inhibitory activity. For example, ectophosphatase inhibitory do not show a high level of fluorescence. The mammalian activity may be measured in cells (e.g., yeast, plant, bacte cells can be tested for the reversal of MDR with ectophos rial, mammalian, and tumor cell lines) by assessing the loss phatase inhibitors by the amount of calcein fluorescence of resistance to drugs. Furthermore, the ectophosphatase detected in the cells. inhibitory molecules of the present invention may be tested for specific inhibitory activity to ectophosphatases versus 0054 Specificity of ectophosphatase inhibitors may be general phosphatases or for specific inhibitory activity for a tested with the screening assays described herein. Inhibitors particular ectophosphatase activity (e.g., apyrase). can be tested for their ability to inhibit acid phosphatases, alkaline phosphatases, myosin phosphatases and the 0060. The present invention also provides physiologi luciferase ATPase. The assays may be performed using cally acceptable compositions comprising an ectophos techniques known in the art. phatase inhibitor, a cytotoxic agent or other active ingredient and a physiologically acceptable carrier or diluent. In certain 0055. In one embodiment of the invention, the ectophos embodiments of the invention, as set forth in detail below, phatase is an apyrase and the ectophosphatase inhibitor is a compositions are provided comprising one or more ecto molecule selected from among molecules represented by the phosphatase inhibitor and one or more plant growth regu Formulae I through XX. In another embodiment, the ecto lator, herbicide, fungicide, insecticide, antibiotic, chemo phosphatase is apyrase and the ectophosphatase inhibitor is therapeutic agent or other active compound. In a further a molecule selected from among molecules represented by embodiment of the invention, the ectophosphatase is the Formulae I through V. selected from the compounds of formulae I-XX in the 0056. In a further embodiment of the invention, the appropriate carriers, diluents or other active ingredients. ectophosphatase is apyrase and the ectophosphatase inhibi 0061 The use of physiologically acceptable carriers or tor is a molecule represented by Formula XX. Formula XX diluents is well known in the art. The techniques of prepa is suramin or 8.8'Carbonylbisimino-3,1-phenylenecarbon ration of pharmaceutical compositions are generally well ylimino(4-methyl-3,1-phenylene)carbonyl iminobis-1,3,5- known in the art as exemplified by Remington's Pharma naphthalenetrisulfonic acid. Suramin has been reported as a ceutical Sciences, 16th Ed. Mack Publishing Company, potent non-competitive inhibitor of ectoapyrase activity 1980, which reference is specifically incorporated herein by associated with the plasma membrane of cholinergic nerve reference in its entirety. Formulations of the present inven terminal of Torpedo mannorata electric organs (arti et al., tion may be stable under the conditions of manufacture and 1996). storage and must be preserved against contamination by 0057. It is contemplated that in certain embodiments of microorganisms. the invention an ectophosphatase inhibitor may inhibit an 0062) The physiological forms of the compositions of the ectophosphatase active on the outer membrane of an invention Suitable for administration include sterile aqueous organelle of a eukaryotic cell. In this manner, contacting the Solutions or dispersions and sterile powders for the extem cell with the ectophosphatase inhibitor may be used to poraneous preparation of sterile injectable solutions or dis decrease the ATP gradient across the organelle and thereby persions. Typical carriers include a solvent or dispersion facilitate uptake of a biologically active agent by the medium containing, for example, water buffered aqueous organelle. Solutions (i.e., biocompatible buffers), ethanol, polyols such US 2006/0276339 A1 Dec. 7, 2006 as glycerol, propylene glycol, polyethylene glycol, Suitable yield a powder of the active ingredient plus any additional mixtures thereof. Surfactants, and vegetable oils. Isotonic desired ingredient from a previously sterile-filtered solution agents such as Sugars or sodium chloride may be incorpo thereof. rated into the Subject compositions. 0068. Other modes of administration can also find use 0063 Pharmaceutical compositions in accordance with with the invention. For instance, pharmaceutical compounds the invention may be used by themselves or in combination may be formulated in Suppositories and, in some cases, with other forms active ingredients or therapeutics. One aerosol and intranasal compositions. For Suppositories, the embodiment of the invention provides formulations for vehicle composition will include traditional binders and parenteral administration, e.g., formulated for injection via carriers such as polyalkylene glycols or triglycerides. Such the intravenous, intramuscular, Sub-cutaneous or other Such Suppositories may be formed from mixtures containing the routes. Typically, Such compositions can be prepared as active ingredient in the range of about 0.5% to about 10% injectables, either as liquid Solutions or Suspensions; Solid (w/w), preferably about 1% to about 2%. forms Suitable for using to prepare solutions or Suspensions 0069. Ectophosphatase inhibitors will commonly com upon the addition of a liquid prior to injection also can be prise from less than 1% to about 10% w/v of a composition prepared; and the preparations also can be emulsified. with an active ingredient, including about 1%, 3%. 5%, &% and about 10%. Greater or lesser amounts of the ectophos 0064 Solutions of the active compounds as free base or phatase inhibitors may similarly be used. Desired concen pharmacologically acceptable salts can be prepared in water trations may readily be determined by serial preparation and Suitably mixed with a surfactant, Such as hydroxypropylcel assay of compositions comprising varying amounts of the lulose. Dispersions also can be prepared in glycerol, liquid selected ectophosphatase inhibitor compound. For example, polyethylene glycols, and mixtures thereof and in oils. in the case of herbicidal compositions, a series of test Under ordinary conditions of storage and use, these prepa compositions comprising from about 0.1% to about 25% rations contain a preservative to prevent the growth of w/v of an ectophosphatase inhibitor together with a test microorganisms. herbicide may be analyzed by leaf painting and comparison 0065. The pharmaceutical forms suitable for injectable of the results. Safety, efficacy, cost and other concerns may use include Sterile aqueous solutions or dispersions; formu each be taken into account in selecting the desired concen lations including sesame oil, peanut oil or aqueous propy trations. Alternatively, pharmaceutical compositions may be lene glycol, and sterile powders for the extemporaneous analyzed using in vitro or in vivo models. preparation of sterile injectable solutions or dispersions. In 0070 Oral compositions may be prepared in the form of all cases, the form must be sterile and must be fluid to the Solutions, Suspensions, tablets, pills, capsules, Sustained extent that easy Syringability exists. It must be stable under release formulations, or powders. These compositions can the conditions of manufacture and storage and must be be administered, for example, by Swallowing or inhaling. preserved against the contaminating action of microorgan Where a pharmaceutical composition is to be inhaled, the isms, such as bacteria and fungi. composition will preferably comprise an aerosol. Exemplary 0.066 Carriers used also can be a solvent or dispersion procedures for the preparation of aqueous aerosols may be medium containing, for example, water, ethanol, polyol (for found in U.S. Pat. No. 5,049,388, the disclosure of which is example, glycerol, propylene glycol, and liquid polyethyl specifically incorporated herein by reference in its entirety. ene glycol, and the like), Suitable mixtures thereof, and Preparation of dry aerosol preparations are described in, for vegetable oils. The proper fluidity can be maintained, for example, U.S. Pat. No. 5,607,915, the disclosure of which is example, by the use of a coating, Such as lecithin, by the specifically incorporated herein by reference in its entirety. maintenance of the required particle size in the case of 0071 Also useful is the administration of the compounds dispersion and by the use of surfactants. The prevention of described herein directly in transdermal formulations with the action of microorganisms can be brought about by permeation enhancers such as DMSO. These compositions various antibacterial and antifungal agents, for example, can similarly include any other suitable carriers, excipients parabens, chlorobutanol, phenol, Sorbic acid, thimerosal, or diluents. Other topical formulations can be administered and the like. In many cases, it will be preferable to include to treat certain disease indications. For example, intranasal isotonic agents, for example, Sugars or sodium chloride. formulations may be prepared which include vehicles that Prolonged absorption of the injectable compositions can be neither cause irritation to the nasal mucosa nor significantly brought about by the use in the compositions of agents disturb ciliary function. Diluents such as water, aqueous delaying absorption, for example, aluminum monostearate saline or other known Substances can be employed with the and gelatin. Subject invention. The nasal formulations also may contain 0067 Sterile injectable solutions are prepared by incor preservatives Such as, but not limited to, chlorobutanol and porating the active compounds in the required amount in the benzalkonium chloride. A Surfactant may be present to appropriate solvent with various of the other ingredients enhance absorption of the Subject compounds by the nasal enumerated above, as required, followed by filtered steril COSa. ization. Generally, dispersions are prepared by incorporating 0072. Upon formulation, solutions may be administered the various sterilized active ingredients into a sterile vehicle in a manner compatible with the dosage formulation and in which contains the basic dispersion medium and the such amount as is therapeutically effective. The formulation required other ingredients from those enumerated above. In of choice can be accomplished using a variety of excipients the case of sterile powders for the preparation of sterile including, for example, pharmaceutical grades of mannitol, injectable solutions, the preferred methods of preparation lactose, starch, magnesium Stearate, sodium saccharin cel are vacuum-drying and freeze-drying techniques which lulose, magnesium carbonate, and the like. Typically, phar US 2006/0276339 A1 Dec. 7, 2006

maceutical compositions will contain from less than 1% to components, or they may have distinct container means for about 95% of the active ingredient, preferably about 10% to each desired agent. When the components of the kit are about 50%. Preferably, between about 10 mg/kg patient provided in one or more liquid solutions, the liquid Solution body weight per day and about 25 mg/kg patient body is an aqueous solution, with a sterile aqueous solution being weight per day will be administered to a patient, including particularly preferred. However, the components of the kit a human patient. The frequency of administration will be may be provided as dried powder(s). When reagents or determined by the care given based on patient responsive components are provided as a dry powder, the powder can ness. Other effective dosages can be readily determined by be reconstituted by the addition of a suitable solvent. It is one of ordinary skill in the art through routine trials estab envisioned that the solvent also may be provided in another lishing dose response curves. container means. The container means of the kit will gen 0.073 Regardless of the mode of administration, suitable erally include at least one vial, test tube, flask, bottle, Syringe pharmaceutical compositions in accordance with the inven or other container means, into which the active compound, tion will generally include an amount of active ingredient and any other desired agent, may be placed and, preferably, admixed with an acceptable pharmaceutical diluent or suitably aliquoted. Where additional components are excipient, such as a sterile aqueous Solution, to give a range included, the kit will also generally contain a second vial or of final concentrations, depending on the intended use. The other container into which these are placed, enabling the techniques of preparation are generally well known in the art administration of separated designed doses. The kits also as exemplified by Remington's Pharmaceutical Sciences, may comprise a second/third container means for containing 16th Ed. Mack Publishing Company, 1980, which reference a sterile, pharmaceutically acceptable buffer or other diluent. is specifically incorporated herein by reference in its entirety. It should be appreciated that endotoxin contamina 0077. The kits also may contain a means by which to tion should be kept minimally at a safe level, for example, administer the compositions to an animal or patient, e.g., one less that 0.5 ng/mg protein. Moreover, for human adminis or more needles or syringes, or even an eye dropper, pipette, tration, preparations should meet sterility, pyrogenicity, gen or other such like apparatus, from which the formulation eral safety and purity standards as required by FDA Office may be injected into the animal or applied to a afflicted area of Biological Standards. of the body. The kits of the present invention will also 0074 The therapeutically effective doses are readily typically include a means for containing the vials, or Such determinable using an animal model. For example, experi like, and other component, in close confinement for com mental animals exhibiting a target infection or other ailment mercial sale, such as, e.g., injection or blow-molded plastic are frequently used to optimize appropriate therapeutic containers into which the desired vials and other apparatus doses prior to translating to a clinical environment. Such are placed and retained. models are known to be very reliable in predicting effective 0078. The invention also provides compositions formu therapies. In certain embodiments, it may be desirable to lated for agricultural use. Examples of Such formulations provide a continuous Supply of therapeutic compositions to include herbicidal, fungicidal and plant growth regulator the patient. For intravenous or intraarterial routes, this is compositions. Specific formulations for plant application are accomplished by drip system. For topical applications, known to those of skill in the art and are described, for repeated application would be employed. For various example, in U.S. Pat. No. 6.242,382, the disclosure of which approaches, delayed release formulations could be used that is specifically incorporated herein by reference in its provided limited but constant amounts of the therapeutic entirety. agent over and extended period of time. For internal appli cation, continuous perfusion of the region of interest may be 0079 Examples of ingredients that may be included in a preferred. This could be accomplished by catheterization, composition of the invention formulated for application to post-operatively in Some cases, followed by continuous plants include Surfactants, solid or liquid carriers, solvents administration of the therapeutic agent. The time period for and binders. Examples of suitable surfactants that may be perfusion would be selected by the clinician for the particu used for application to plants include the alkali metal, lar patient and situation, but times could range from about alkaline earth metal or ammonium salts of aromatic Sulfonic 1-2 hours, to 2-6 hours, to about 6-10 hours, to about 10-24 acids, e.g., ligno-, phenol-, naphthalene- and dibutylnaph hours, to about 1-2 days, to about 1-2 weeks or longer. thalenesulfonic acid, and of fatty acids of arylsulfonates, of Generally, the dose of the therapeutic composition via alkyl ethers, of lauryl ethers, offatty alcohol sulfates and of continuous perfusion will be equivalent to that given by fatty alcohol glycol ether Sulfates, condensates of Sulfonated single or multiple injections, adjusted for the period of time naphthalene and its derivatives with formaldehyde, conden over which the injections are administered. It is believed that sates of naphthalene or of the naphthalenesulfonic acids with higher doses may be achieved via perfusion, however. phenol and formaldehyde, condensates of phenol or phenol sulfonic acid with formaldehyde, condensates of phenol 0075. Therapeutic kits comprising the compositions with formaldehyde and sodium sulfite, polyoxyethylene described herein are also provided by the invention. Such octylphenyl ether, ethoxylated isooctyl-, octyl- or nonylphe kits will generally contain, in Suitable container means, a nol, tributylphenyl polyglycol ether, alkylaryl polyether pharmaceutically or agriculturally acceptable formulation of alcohols, isotridecyl alcohol, ethoxylated castor oil, ethoxy the active ingredient. The kits also may contain other lated triarylphenols, salts of phosphated triarylpheno pharmaceutically acceptable formulations, such as an anti lethoxylates, lauryl alcohol polyglycol ether acetate, Sorbitol infective agent, including an insecticide, antifungal or anti esters, lignin-sulfite waste liquors or methylcellulose, or bacterial, as well as a herbicide. mixtures of these. Common practice in the case of Surfactant 0.076 The kits may have a single container means that use is to include about 0.5 to 25% by weight, based on the contains the active ingredient, with or without any additional total weight of the solid mixture. US 2006/0276339 A1 Dec. 7, 2006

0080 Compositions for application to plants may be S-metolachlor, nicosulfuron, MSMA, EpicTM and Bal solid or liquid. Where solid compositions are used, it may be anceTM. In one embodiment of the invention, the ectophos desired to include one or more carrier materials with the phatase inhibitor is selected from the group of the com active compound. Examples of carriers include mineral pounds of formulae I-XX. In certain other embodiments of earths such as silicas, silica gels, silicates, talc, kaolin, the invention, compositions with fungicidal activity are attaclay, limestone, chalk, loess, clay, dolomite, diatoma provided which comprise one or more ectophosphatase ceous earth, calcium Sulfate, magnesium Sulfate, magnesium inhibitor(s) in combination with metalaxyl, tebuconazole, oxide, ground synthetic materials, fertilizers such as ammo propiconazole, chlorothalonil and/or fluconazole. nium sulfate, ammonium phosphate, ammonium nitrate, 0084. Non-limiting examples of combinations of cyto thiourea and urea, products of vegetable origin such as toxic agents and ectophosphatase inhibitors for use in accor cereal meals, tree bark meal, wood meal and nutshell meal, dance with the invention include: fluconazole with com cellulose powders, attapulgites, montmorillonites, mica, Ver pound(s) of formula II, IX, XIV. XVI, XV. X and/or XII: miculites, synthetic silicas and synthetic calcium silicates, or formula I and/or II with pendimethalin, dicamba, 2,4-D, mixtures of these. bentazon, trifluralin, flufenacet/isoxaflutole or isoxaflutole; 0081 For liquid solutions, water-soluble compounds or glufosinate with formula II; oryzalin with formula I; nico salts may be included, such as sodium sulfate, potassium sulflron with formula II; MSMA with formula XVIII; S-me Sulfate, Sodium chloride, potassium chloride, sodium tolachlor with formula VI and/or X; metribuzin with formula acetate, ammonium hydrogen Sulfate, ammonium chloride, I, II and/or X: diuron with formula VI; metalaxyl with ammonium acetate, ammonium formate, ammonium formula X: chlorothalonil with formula II, X, IX, XI, XVI; oxalate, ammonium carbonate, ammonium hydrogen car propiconazole with formula I, X, XIV and/or XVI; manco bonate, ammonium thiosulfate, ammonium hydrogen Zeb with formula I, VI and/or X; captain with formula XIV diphosphate, ammonium dihydrogen monophosphate, and/or XVI; tebuconazole with formula I and/or X; imida ammonium sodium hydrogen phosphate, ammonium thio cloprid with formula II, X, XVIII, XVI and/or XV: and cyanate, ammonium sulfamate or ammonium carbamate. fertilizers such as Nitrogen, Phosphate, Potash—12:12:12 0082) Other exemplary components in compositions of with formula I and/or II. the invention include binders such as polyvinylpyrrolidone, 0085 Also envisioned for use with the invention are polyvinyl alcohol, partially hydrolyzed polyvinyl acetate, compositions comprising combinations of ectophosphatase carboxymethylcellulose, starch, vinylpyrrolidone/vinyl inhibitors and cytotoxic agents or other active ingredients, acetate copolymers and polyvinyl acetate, or mixtures of including a herbicide, insecticide, antibiotic, fungicide, plant these; lubricants such as magnesium Stearate, Sodium Stear growth regulator and/or hormone. Such combinations may ate, talc or polyethylene glycol, or mixtures of these; anti provide enhanced activity of the active ingredient relative to foams such as silicone emulsions, long-chain alcohols, phos the use of a single ectophosphatase inhibitor. Non-limiting phoric esters, acetylene diols, fatty acids or organofluorine examples of Such combinations of ectophosphatase inhibi compounds, and complexing agents such as: salts of ethyl tors include combinations of two, three, four or more enediaminetetraacetic acid (EDTA), salts of trinitrilotriace ectophosphatase inhibitors selected from formulas I, II, VI, tic acid or salts of polyphosphoric acids, or mixtures of X, XV, XIV, XVI, XVI, XV, and XVIII. Included for these. illustrative purposes are the following combinations: I and 0083. In certain embodiments of the invention, compo II; I, II and X; XIV and XVI; XVIII and XVI; XVI, XVI and sitions are provided with herbicidal activity which comprise XV; VI and X; II and X; and I and XVIII. one or more ectophosphatase inhibitor(s) and a herbicide 0086) Specifically contemplated by the inventors are selected from the group consisting of pendimethalin, compositions comprising an ectophosphatase inhibitor and dicamba, 2,4-D, glufosinate, bentazon, trifluralin, oryzalin, an active ingredient set forth in Table 1.

TABLE 1. Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Bis(2-ethylhexyl) phthalate 117-81-7 3E--OS NA11 NFA Alkyl Phthalate Butylbenzyl phthalate 85-68-7 NA. 141 3O80 NAA Alkyl Phthalate Chlorthal-dimethyl 1861-32-1 78701 179 Herbicide Alkyl Phthalate Di-n-octyl phthalate 117-84-O NA303 223 NA Alkyl Phthalate Dibutyl phthalate 84–74-2 28001 199 nSect Alkyl Phthalate Repellent Diethyl phthalate 84-66-2 1E--OS 3326 NAA Alkyl Phthalate Diisodecyl phthalate NA 1037 NA132 2513 NSA Alkyl Phthalate Dimethyl phthalate 131-11-3 280O2 232 nSect Alkyl Phthalate Repellent Dioctyl terephthalate NA 724 NA 133 2S28 NAA Alkyl Phthalate Diphenyl phthalate 84-62-8 17OO1 NA147 NFA Alkyl Phthalate Isooctyl phthalate 27554-26-3 NA483 2262 NAA Alkyl Phthalate n-Butyl phthalate 84–74-2 28001 3O81 insecticide Alkyl Phthalate Poly glyceryl phthalate ester of NA327 NA 608 3331 Adjuvant, Alkyl Phthalate coconut oil fatty acid Soap/Surfactant US 2006/0276339 A1 Dec. 7, 2006 11

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class 1,3-Dimethyl-1,1,3,3- 22232-20-8 346O1 NA303 NA Bis-Carbamate disiloxanetetrol-1,3- bis(dimethylthiocarbamate) 2,3(and 3,4)-Dichlorobenzyl 62O46-37-1 3E--OS NA 136 SCC ici N-Methyl Carbama methylcarbamates 2,4-Dimethyl-1,3-dithiolane-2- 26419-73-8 4E--05 NA143 SCC ici N-Methyl Carbama carboxaldehyde O (methylcarbamoyl)oxime 2-(4,5-Dimethyl-1,3-dioxolan ######## 4E--05 NA. 145 SCC ici N-Methyl Carbama 2-yl)phenyl-N- methylcarbamate 2-chloro-4,5-xylyl N-hydroxy 14357-82-5 2E--OS NA117 SCC ici N-Methyl Carbama N-methylcarbamate 2-cyclopentylphenyl 3282-00-6 3E--OS NA132 SCC ici N-Methyl Carbama methylcarbamate 2-Hydroxyphenyl 10309-97-4 2E--OS NA 118 SCC ici N-Methyl Carbama methylcarbamate 3,4-Dichlorobenzyl 2328-31-6 3E--OS NA 136 SCC ici N-Methyl Carbama methylcarbamate 3,5-Diisopropylphenyl 330-64-3 4E--05 NA142 SCC ici e N-Methyl Carbama methylcarbamate 3-hydroxycarbofuran 166SS-82-6 2E--OS 4074 Breakdown N-Methyl Carbama product 3-iodo-2-propynyl butyl SS4O6-53-6 1E--OS 1938 Fungicide, Other Carbamate carbanate Woo Preservative 3-ketocarbofuran 16709-30-1 NA. 176 NA. 164 Breakdown N-Methyl Carbama product 4 17702-57-7 4E--05 NA142 SCC ici N-Methyl Carbama (((Dimethylamino)methylene)amino)- m-tolyl methylcarbamate 4-(Methylamino)-3,5-xylyl 10389-50-1 2E--OS NA 118 SCC ici N-Methyl Carbama methylcarbamate 4-(Methylformamido)-3,5- 10233-94-0 2E--OS NA 118 SCC ici N-Methyl Carbama xylyl methylcarbamate 4-(Methylthio)-m-tolyl 3566-00-5 6E--05 NA. 157 SCC ici N-Methyl Carbama methylcarbamate 4-Amino-3,5-xylyl 831-76-5 2E--OS NA117 SCC ici N-Methyl Carbama methylcarbamate 5,6,7,8-Tetrahydro-1-naphthyl 1136-84-1 4E--05 NA148 SCC ici N-Methyl Carbama methylcarbamate 6-(and 2)-chloro-3,4-xylyl 8063-85-2 38.701 NA322 SCC ici N-Methyl Carbama methylcarbamate 6-Methyl-2-propyl-4- 2532-49-2 6E--05 NA. 157 NA Other Carbamate pyrimidinyl dimethylcarbamate Alanycarb 831.30-01-2 NA. 175 NA47 SCC ici Other Carbamate Aldicarb 116-06-3 983O1 575 SCC ici N-Methyl Carbama Nematicide Aldicarb sulfoxide 1646-87-3 1E--OS 2361 Breakdown N-Methyl Carbama product Aldoxycarb 1646-88-4 1E--OS 2265 Breakdown N-Methyl Carbama product Allyxycarb 6392-46-7 3E--OS NA 133 insecticide N-Methyl Carbamate Aminocarb 2O32-59-9 444O1 2435 insecticide N-Methyl Carbamate ASulam 3337-71-1 1E--OS 5076 Herbicide Other Carbamate ASulam, Sodium salt 2302-17-2 1E--OS 1746 Herbicide Other Carbamate Bendiocarb 22781-23-3 1E--OS 1924 insecticide N-Methyl Carbama Benfuracarb 82560-54-1 1E--OS NA48 insecticide Other Carbamate Bufencarb 2282-34-O 593O2 91 insecticide N-Methyl Carbamate Bufencarb 806S-36-9 593O3 NA485 insecticide N-Methyl Carbamate Bufencarb, component of (with 672-04-8 S93O1 NA484 insecticide N-Methyl Carbamate 0593.02) Butacarb 26SS-19-8 3E--OS NA135 insecticide N-Methyl Carbamate Butocarboxim 34681-10-2 NA. 175 NA49 insecticide N-Methyl Carbamate Butoxycarboxim 34681-23-7 1E--OS 22O1 insecticide N-Methyl Carbamate Butylate 2008-41-5 41405 565 Herbicide Thiocarbamate Calcium S895-18-1 145O1 NA. 139 Microbiocide Dithiocarbamate ethylenebis(dithiocarbamate) US 2006/0276339 A1 Dec 7, 2006 12

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Carbanolate 671-04-5 NA 124 insecticide N-Methyl Carbamate Carbaryl 63-25-2 105 insecticide, N-Methyl Carbamate Plant Growth Regulator, Nematicide Carbofuran 1563-66-2 106 insecticide, N-Methyl Carbamate Nematicide Carbosulfan SS285-14-8 906O2 2182 insecticide N-Methyl Carbamate Chlorbufam 1967-16-4 6E--05 NA. 157 Herbicide Other Carbamate Chlorprocarb 23121-99-53 3E--OS NA 136 Herbicide Other Carbamate Chlorpropham 101-21-3 18301 141 Herbicide, Other Carbamate Plant Growth Regulator Cloethocarb S1487-69-5 NA1OO insecticide, N-Methyl Carbamate Molluscicide Cufraneb 11096-18-7 NA 18O Fungicide Dithiocarbamate Cycloate 1134-23-2 S16 Herbicide Thiocarbamate DeSmedipham 13684-56-5 1748 Herbicide Bis-Carbamate Diammonium ######## NA 140 Microbiocide Dithiocarbamate ethylenebis(dithiocarbamate) Dichlormate 1966-58-1 690 Herbicide N-Methyl Carbamate Diethofencarb 871.30-20-9 NA 183 Fungicide Other Carbamate Dimepiperate 61432-SS-1 NA 18S Herbicide Thiocarbamate Dimetan 122-15-6 NA112 insecticide Other Carbamate Dimethyl (4-methyl-1,3- S1543-98-7 NA 888 Fungicide Bis-Carbamate phenylenebis(iminocarbonyl H-benzimidazole-1,2- diyl)biscarbamate Dimetilan 644-64-4 NA 844 SCC icide Other Carbamate Dioxacarb 6988-21-2 4067 SCC icide N-Methyl Carbamate EPTC 759-94-4 264 Herbicide Thiocarbamate Esprocarb 85785-20-2 NA2O2 Herbicide Thiocarbamate Ethiofencarb 29973-13-5 NASO SCC icide N-Methyl Carbamate Ethiolate 2941-55-1 1793 Herbicide Thiocarbamate Fenethacarb 30O87-47-9 NA. 141 SCC icide N-Methyl Carbamate Fenobucarb 3766-81-2 NAS1 SCC icide N-Methyl Carbamate Fenothiocarb 628SO-32-2 NA 187 SCC icide Thiocarbamate Fenoxycarb 791.27-8O-3 2283 SCC icide, Other Carbamate SCC Growth Regu ator Fenoxycarb 72490-01-8 NA228 NA228 SCC icide, Other Carbamate SCC Growth Regu ator Ferbam 14484-64-1 348O1 288 Fungicide Dithiocarbamate Ferric nitroso dimethyl 83542-83-0 SE-OS NA149 Microbiocide Dithiocarbamate dithiocarbamate Formetanate 22259-30-9 SE-OS NA1SO SCC icide N-Methyl Carbamate Formetanate hydrochloride 23422-53-9 973O1 111 SCC icide N-Methyl Carbamate Furathiocarb 6S907-30-4 NA. 176 NAS2 SCC icide Thiocarbamate Solan 119-38-O SE-OS NA 155 SCC icide Other Carbamate Sopolinate 3134-70-1 NA232 NA232 Herbicide Thiocarbamate Soprocarb 2631-40-5 SE-OS NAS3 SCC icide N-Methyl Carbamate Karbutilate 4849-32-5 974O1 691 Herbicide Other Carbamate m-Cumenyl methylcarbamate 64-OO-6 47801 NA 414 SCC icide N-Methyl Carbamate Mancopper S3988-93-5 NA 181 NA 18O Fungicide Dithiocarbamate Mancozeb ######## 14504 211 Fungicide Dithiocarbamate, Inorganic-Zinc Maneb 12427-38-2 145OS 369 Fungicide Dithiocarbamate Maneb and nickel sulfate 8OOS-46-7 6E--05 NA. 158 Fungicide Dithiocarbamate, hexahydrate (014505 + 050505) Inorganic-Nickel Manganous 15339-36-3 NA 304 Fungicide Dithiocarbamate dimethyldithiocarbamate Mecarbinizid 27386-64-7 NA. 157 NA Other Carbamate Mercuric dimethyl 15415-64-2 709 Microbiocide Inorganic-Mercury, dithiocarbamate Heavy metal, Dithiocarbamate Metam sodium, dihydrate 137-42-8 39003 NA. 163 Fumigant, Dithiocarbamate Fungicide, Microbiocide, Algaecide, Nematicide US 2006/0276339 A1 Dec 7, 2006 13

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Metam-sodium 6734-80-1 39003 616 Fumigant, Dithiocarbamate Herbicide, Fungicide, Microbiocide, Algaecide, Nematicide Methasulfocarb 66952-49-6 NA2O2 Fungicide, Thiocarbamate Plant Growth Regulator Methiobencarb 18357-78-3 NA232 NA232 Herbicide Thiocarbamate Methiocarb 1E--OS 375 insecticide, N-Methyl Carbamate Molluscicide Methiocarb sulfone 2179-25-1 4077 Breakdown N-Methyl Carbamate product Methiocarb sulfoxide ######## Breakdown N-Methyl Carbamate product Methomyl 16752-77-5 383 insecticide, N-Methyl Carbamate Breakdown product Metiram 146O1 493 Fungicide Dithiocarbamate, Inorganic-Zinc Metolcarb 1129-41-5 NA2O2 NA2O1 insecticide N-Methyl Carbamate Mexacarbate 315-18-4 442O1 623 insecticide N-Methyl Carbamate Mobam 1079-33-0 904O1 NA 848 insecticide N-Methyl Carbamate Molinate 2212-67-1 414O2 449 Herbicide Thiocarbamate Molinate sulfoxide NA 1052 NA 156 408O Breakdown Thiocarbamate broduct Morpholinomethyl 31848-11-0 NA. 158 Microbiocide Dithiocarbamate dimethyldithiocarbamate Nabam 142-59-6 417 Fungicide, Dithiocarbamate Herbicide Nitrilacarb 29672-19-3 NA 129 insecticide Other Carbamate o-(2-Propynyloxy)phenyl 3279-46-7 NA. 138 insecticide N-Methyl Carbamate methylcarbamate Orbencarb 34622-58-7 NA 189 NA 188 Herbicide Thiocarbamate Oxamyl 23135-22-0 1E--OS 1910 insecticide, N-Methyl Carbamate Nematicide Pebulate 1114-71-2 41403 590 Herbicide Thiocarbamate Phenisopham 57375-63-0 NA. 209 NA2O8 Herbicide Bis-Carbamate Phenmedipham 13684-63-4 98.701 675 Herbicide Bis-Carbamate Phenmedipham-ethyl 13684-44-1 4E--05 NA149 Herbicide Bis-Carbamate Phenylmercuric 324O7-99-1 66008 NA555 Microbiocide, Organomercury, dimethyldithiocarbamate Fungicide Dithiocarbamate, Heavy metal Pirimicarb 23103-98-2 1E--OS 1875 insecticide N-Methyl Carbamate Pirimicarb sulfone NA 1 OSO NA1SS Breakdown N-Methyl Carbamate product Pirimicarb sulfoxide NA 1049 NA1SS 4091 Breakdown N-Methyl Carbamate product Potassium ammonium 22221-14-3 14507 NA. 141 Microbiocide Dithiocarbamate ethylenebis(dithiocarbamate) Potassium asulam 14089-43-1 NA893 Herbicide Other Carbamate Potassium dimethyl dithio 128-03-0 1934 Microbiocide Dithiocarbamate carbamate Potassium N-hydroxymethyl 51026-28-9 1824 NA Dithiocarbamate N-methyldithio carbamate Potassium N-methyldithio 137-41-7 39002 970 Fumigant, Dithiocarbamate carbamate Fungicide, Microbiocide, Algaecide, Nematicide Promacyl 34264-24-9 NA. 209 insecticide N-Methyl Carbamate Promecarb 2631-37-O 4092 insecticide N-Methyl Carbamate Propamocarb 24579-73-5 2147 Fungicide Other Carbamate Propamocarb hydrochloride 25606-41-1 4022 Fungicide Other Carbamate Propham 122-42-9 339 Herbicide, Other Carbamate Plant Growth Regulator Propineb 12071-83-9 SE-OS NA 155 Fungicide, Dithiocarbamate, Microbiocide Inorganic-Zinc Propoxur 114-26-1 62 insecticide N-Methyl Carbamate US 2006/0276339 A1 Dec. 7, 2006 14

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Propoxur, other related NA 1073 NA. 161 90062 insecticide N-Methyl Carbamate Prosulfocarb 52888-80-9 NA 18S NA 184 Herbicide Thiocarbamate Prothiocarb 19622-08-3 NA 183 NA 182 Fungicide Thiocarbamate Prothiocarb hydrochloride 19622-19-6 NA 200 NA 199 Fungicide Thiocarbamate Pyributicarb 88678-67-5 NA 229 NA 229 Herbicide Thiocarbamate Pyrolan 87-47-8 6E--05 NA. 157 insecticide Other Carbamate S-tert-Butyl 2212-63-7 NA128 Herbicide Thiocarbamate dipropylthiocarbamate Sodium dimethyl dithio 128-04-1 34804 S48 Fungicide Dithiocarbamate carbamate Sulfallate 95-06-7 39001 115 Herbicide Dithiocarbamate Swep 1918-18-9 846O1 4098 NA Other Carbamate Terbutol ######## 388O1 51 Herbicide N-Methyl Carbamate Tert-butyl dimethyl trithio 3304-97-0 34807 1383 Rodent Dithiocarbamate peroxycarbamate Repellent Tert NA 1130 NA166 91383 NA Dithiocarbamate butyldimethyltrithioperoxycarbamate, other related Thiobencarb 2824.9-77-6 1E--OS 1933 Herbicide Thiocarbamate Thiobencarb sulfoxide NA 1042 NA. 139 2937 Breakdown Thiocarbamate product Thiocarboxime 25171-63-5 NA 156 NA N-Methyl Carbamate Thiodicarb 59669-26-0 22O2 Molluscicide, Thiocarbamate insecticide Thiofanox 391.96-18-4 2938 insecticide N-Methyl Carbamate Thiram 137-26-8 589 Fungicide Dithiocarbamate Thiram and NAD and IBA and 75497-92-6 NA 463 Fungicide, Dithiocarbamate 2-methyl-1- Plant Growth naphthaleneacetamide and 2 Regulator methyl-1-naphthaleneacetic acid Tiocarbazil 36756-79-3 1E--OS NA911 Herbicide Thiocarbamate Triallate 23O3-17-5 78802 49 Herbicide Thiocarbamate Tricopper dichloride 7O76-63-3 SE-OS NA. 152 Microbiocide Dithiocarbamate, dimethyldithiocarbamate Inorganic-Copper Trimethacarb 12407-86-2 2962 insecticide, N-Methyl Carbamate Molluscicide, Dog and Cat Repellent Trimethacarb, (2,3,5)- 26SS-15-4 NA 882 insecticide, N-Methyl Carbamate component of Molluscicide Trimethacarb, (3,4,5)- 2686-99-9 NA 881 insecticide, N-Methyl Carbamate component of Molluscicide Vernolate 92.9-77-7 41.404 1987 Herbicide Thiocarbamate NA. 176 NAS4 insecticide N-Methyl Carbamate Xylylcarb NA. 176 NASS insecticide N-Methyl Carbamate Zineb 14506 627 Fungicide Dithiocarbamate, Inorganic-Zinc Zineb-ethylene thiuram NA217 NA 216 Fungicide Dithiocarbamate, disulfide adduct Inorganic-Zinc Ziram 348OS 629 Fungicide, Dithiocarbamate, Microbiocide, Inorganic-Zinc Dog and Cat Repellent Ziram, cyclohexylamine 34806 1328 Dog and Cat Dithiocarbamate, complex Repellent, Inorganic-Zinc Fungicide Acetamiprid 3S410-20-7 990SO NA 864 insecticide Chloro-nicotinyl Imidacloprid OS827-78-9 ##### 3849 insecticide Chloro-nicotinyl Imidacloprid 38261-41-3 ##### NA 111 insecticide Chloro-nicotinyl Thiacloprid 11988-49-9 NA2O1 NA2O1 insecticide Chloro-nicotinyl Halofenozide 12226-61-6 ##### SO19 insecticide Diacylhydrazine Methoxyfenozide 61OSO-58-4 ##### NA983 insecticide Diacylhydrazine Tebufenozide 1241O-23-8 ##### 3957 insecticide Diacylhydrazine Bacillus thuringiensis Cry1F NA. 1486 6481 NA22O insecticide GE Crop protein and the genetic material necessary for its production (plasmid insert PHI8999) in corn pla US 2006/0276339 A1 Dec. 7, 2006 15

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Bacillus thuringiensis Cry1Ab NA. 1487 64.30 NA22O Insecticide GE Crop Delta-Endotoxin and the Genetic Material Necessary for ts Production in Corn MON 810 Bacillus thuringiensis delta 68038-71-1 NA. 160 39S4 Insecticide GE Crop endotoxin produced in corn Bacillus thuringiensis subsp. NA 1226 6463 NA. 170 Insecticide GE Crop Kurstaki CryIA (c) delta endotoxin and the genetic material necessary for its production in corn Bacillus thuringiensis subsp. 68038-71-1 6444 SO48 Insecticide GE Crop Kurstaki, delta-endotoxin as produced in corn by an HD-1 gene, and its controlling sequences and Bacillus thuringiensis subsp. NA 1233 6466 NA171 Insecticide GE Crop Tolworthi Cry9C protein and he genetic material necessary or its production (pRVA9909) in corn p Bacillus thuringiensis NA 1237 6432 NA171 Insecticide GE Crop subspecies Tenebrionis delta endotoxin as produced in potato by Cry IIIA gene and its controlling sequenc Bacillus thuringiensis var. NA148O 6402 3554 Insecticide GE Crop Kurstaki protein in cottonseed Bacillus thuringiensis, Subsp. 68038-71-1 6461 3986 Insecticide GE Crop Kurstaki, strain HD-1, delta endotoxin as produced in corn by a Cry 1A(b) gene and its controlling HD-1 Protein as encoded by NA 1273 6408 NA173 Insecticide GE Crop Bacillus thuringiensis subsp. kurstaki gene and produced in COil Plant pesticide Bacillus NA 1285 6458 NA174 Insecticide GE Crop huringiensis Cry1A(b) delta endotoxin and the genetic material necessary for its production (plasmid V Potato leafroll virus (PLRV) NA 1295 6469 NA. 175 Fungicide GE Crop replicase protein as produced in potato plants 1,1-trichloroethane 71-55-6 812O1 138 Solvent tlalogena organic ,1,2-trichloro-1,2,2-trifluoro 76-13-1 NA972 2960 Solvent 8. ogena e organic ,1,2-trichloroethane 79-00-5 812O3 1425 Solvent ogena organic 2,3,4-Tetrachlorobenzene 634-66-2 61101 NA494 NA ogena organic 120-82-1 81101 600 NA ogena organic 78-87-5 290O2 2SO1 Fumigant, ogena organic Nematicide 2-Dichloropropane mixt. with ######## 29004 NA215 Fumigant, tlalogena organic 3-dichloropropene and Nematicide methyl isothiocyanate 2-dichloropropane, 1,3- NA 1022 290O2 185 Fumigant, tlalogena organic dichloropropene and related C3 Nematicide

3-Dichloro-1-propene, mixt. 8003-19-8 290O3 NA214 Fumigant, tlalogena organic with 1,2-dichloropropane Nematicide 3-dichloropropene S42-75-6 29001 573 Fumigant, tlalogena organic Nematicide -chloro-1,1-difluoro ethane 75-68-3 NA 423 3103 Solvent ogena organic -chlorobutane 109-69-3 NA 425 1151 Solvent ogena organic 3-chloro-2-methyl propene S63-47-3 NA422 2463 NA ogena organic Bis(2,2-dichloroethyl)ether 1191-17-9 295O2 NA217 NA ogena organic Bromoethane 74-96-4 NA131 2427 NA ogena organic Carbon tetrachloride S6-23-5 16SO1 109 Solvent, ogena organic Fumigant US 2006/0276339 A1 Dec. 7, 2006 16

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical C 8SS

Carbon tetrachloride with EDB S3908-27-3 16SO3 NA. 146 Fumigant, 8 ogena e organic & EDC Nematicide Carbon tetrachloride with EDC ######## 16SO2 NA. 145 Fumigant, ogena organic Nematicide Carbon tetrafluoride 75-73-0 NA113 3.099 Propellant ogena organic Chloro difluoro methane 75-45-6 15 3104 Propellant, ogena organic Fumigant, insecticide Chlorodibromomethane 124-48-1 NA 426 2462 NA ogena organic Chloroform 67-66-3 20701 133 Solvent, ogena organic Fumigant DBCP 96-12-8 11301 183 Fumigant, ogena organic Nematicide DBCP, other related NA1079 NA. 161 901.83 Fumigant, ogena organic Nematicide Dichloroethylene, 1,1- 7S-35-4 6E--05 NA13 impurity ogena organic Dichlorofluoromethane 75-43-4 NA348 1815 Propellant ogena organic Difluoro diphenyl 475-26-3 32001 NA293 NA ogena organic Erichloroethane Ethane, 1,1,1,2-tetrafluoro 811-97-2 1E--OS NA873 NA ogena organic Ethyl chloride 7S-OO-3 NA114 31.98 NA ogena organic Ethylene chlorobromide 107-04-0 42001 2557 NA ogena organic Ethylene dibromide 106-93-4 42002 271 Fumigant, ogena organic Nematicide Ethylene dichloride 107-06-2 42003 274 Fumigant, ogena organic insecticide Freon 11 75-69-4 13 1460 Propellant, ogena organic Fumigant, insecticide Freon 12 75-71-8 14 1459 Propellant, ogena organic Fumigant, insecticide Halazone 80-13-7 772.01 316 NA ogena organic Hexachloroacetone 116-16-5 43701 320 Herbicide 8. ogena organic Hexachloroacetone, other NA 1090 NA. 162 90320 Herbicide ogena organic related Hexachloroethane 67-72-1 NA22 NA ogena organic Hydrofluorocarbon 152A NA 617 2599 Propellant 8. ogena organic Methyl bromide 74-83-9 385 Fumigant, ogena organic insecticide, Herbicide, Nematicide Methyl chloride 74-87-3 532O2 2677 NA ogena organic Methyl iodide 74-88-4 NA177 NA. 16S Fumigant, ogena organic Nematicide Methylene chloride 75-09-2 42004 388 Solvent, Dog ogena organic and Cat Repellen Ortho-dichlorobenzene 95-SO-1 578 insecticide ogena organic Ortho-dichlorobenzene, other NA 1116 NA. 16S 90683 insecticide ogena organic related Para-dichlorobenzene 106–46-7 455 insecticide, ogena organic nSect Repellent, Rodenticide, Fungicide Pentachloroethane 76-01-7 6E--05 NA. 159 ogenated organic Propargyl bromide 106-96-7 68.701 NA 608 ogenated organic Tetrachloroethane 79-34-5 3559 Solvent, ogenated organic Fumigan Tetrachloroethylene 127-18-4 785O1 1174 Solvent ogenated organic Tetraiodo ethylene S13-92-8 46908 582 NA ogenated organic trans-1,3-Dichloropropene 1 OO61-02-6 NA227 NA227 Fumigan ogenated organic Trichloro ethylene 79-01-6 812O2 595 NA ogenated organic Trichlorobenzene 87-61-6 NA971 1619 NA ogenated organic Trichlorofluoromethane 75-69-4 13 3482 Propellant, ogenated organic Fumigant, insecticide Trichloromethane 67-66-3 20701 1758 Solvent, ogenated organic Fumigan US 2006/0276339 A1 Dec. 7, 2006 17

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemica Class

2,3(and 3,4)-Dichlorobenzyl 62O46-37-1 ##### NA 136 insecticide N-Me ny Car 88 methylcarbamates 2,4-Dimethyl-1,3-dithiolane-2- 26419-73-8 ##### NA143 insecticide N-Me ny Car 88 carboxaldehyde O (methylcarbamoyl)oxime 2-(4,5-Dimethyl-1,3-dioxolan 1905930 ##### NA. 145 insecticide N-Me ny Car 88 2-yl)phenyl-N- methylcarbamate 2-chloro-4,5-xylyl N-hydroxy 14357-82-5 ##### NA117 insecticide N-Me ny Car 88 N-methylcarbamate 2-cyclopentylphenyl 3282-00-6 ##### NA132 insecticide N-Me ny Car 88 methylcarbamate 2-Hydroxyphenyl 10309-97-4 ##### NA 118 insecticide N-Me ny Car 88 methylcarbamate 3,4-Dichlorobenzyl 2328-31-6 ##### NA 136 insecticide ny Car 88 methylcarbamate 3,5-Diisopropylphenyl 330-64-3 ##### NA142 insecticide ny Car 88 methylcarbamate 3-hydroxycarbofuran 166SS-82-6 ##### 4074 Breakdown N-Me ny Car 88 product 3-ketocarbofuran 16709-30-1 NA. 176 NA. 164 Breakdown N-Me ny Car 88 product 4 17702-57-7 ##### NA142 insecticide N-Me ny Car 88 (((Dimethylamino)methylene)amino)- m-tolyl methylcarbamate 4-(Methylamino)-3,5-xylyl 10389-50-1 ##### NA 118 insecticide ny Car 88 methylcarbamate 4-(Methylformamido)-3,5- 10233-94-0 ##### NA 118 insecticide ny Car 88 xylyl methylcarbamate 4-(Methylthio)-m-tolyl 3566-00-5 ##### NA. 157 insecticide ny Car 88 methylcarbamate 4-Amino-3,5-xylyl 831-76-5 ##### NA117 insecticide ny Car 88 methylcarbamate 5,6,7,8-Tetrahydro-1-naphthyl 1136-84-1 ##### NA148 insecticide ny Car 88 methylcarbamate 6-(and 2)-chloro-3,4-xylyl 8063-85-2 38.701 NA322 insecticide ny Car 88 methylcarbamate Aldicarb 116-06-3 983O1 575 insecticide, ny Car 88 Nematicide Aldicarb sulfoxide 1646-87-3 ##### 2361 Breakdown ny Car 88 product Aldoxycarb 1646-88-4 ##### 2265 Breakdown ny Car 88 product Allyxycarb 6392-46-7 ##### NA 133 insectici ny 88 Aminocarb 2O32-59-9 444O1 2435 insectici ny 88 Bendiocarb 22781-23-3 ##### 1924 insectici ny 88 Bufencarb 2282-34-O 593O2 91 insectici ny 88 Bufencarb 806S-36-9 593O3 NA485 insectici ny 88 Bufencarb, component of (with 672-04-8 S93O1 NA484 insectici ny 88 0593.02) Butacarb 26SS-19-8 ##### NA135 ny 88 Butocarboxim 34681-10-2 NA. 175 NA49 ny 88 Butoxycarboxim 34681-23-7 ##### 22O1 ny 88 Carbanolate 671-04-5 ##### NA 124 ny 88 Carbaryl 63-25-2 568O1 105 ny 88

Carbofuran 1563-66-2 906O1 106 ny 88

Carbosulfan SS285-14-8 906O2 2182 ny 88 Cloethocarb S1487-69-5 ##### NA1OO ny 88 e

Dichlormate 1966-58-1 ##### 690 ny 88 Dioxacarb 6988-21-2 ##### 4067 ny 88 Ethiofencarb 29973-13-5 ##### NASO ny 88 Fenethacarb 30O87-47-9 ##### NA. 141 ny 88 Fenobucarb 3766-81-2 NA. 176 NAS1 ny 88 Formetanate 22259-30-9 ##### NA1SO ny 88 Formetanate hydrochloride 23422-53-9 973O1 111 ny 88 US 2006/0276339 A1 Dec. 7, 2006 18

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemica Class Isoprocarb 2631-40-5 ##### NAS3 insecticide ny Carbama m-Cumenyl methylcarbamate 64-OO-6 47801 NA 414 insecticide ny Carbama Methiocarb 2O32-65-7 ##### 375 insecticide, ny Carbama Molluscicide Methiocarb sulfone 2179-25-1 ##### 4077 Breakdown ny Carbama product Methiocarb sulfoxide 267266 ##### 4O78 Breakdown ny Carbama product Methomyl 16752-77-5 903O1 383 ny Carbama

Metolcarb 1129-41-5 NA2O2 NA2O1 ny Carbama Mexacarbate 315-18-4 442O1 623 ny Carbama Mobam 1079-33-0 904O1 NA 848 ny Carbama o-(2-Propynyloxy)phenyl 3279-46-7 ##### NA. 138 ny Carbama methylcarbamate Oxamyl 23135-22-0 ##### 1910 ny Carbama

Pirimicarb 23103-98-2 ##### 1875 ny Carbama Pirimicarb sulfone NA 1 OSO NA1SS 4O90 ny Carbama

Pirimicarb sulfoxide NA 1049 NA1SS 4091 ny Carbama

Promacyl 34264-24-9 NA. 209 NA. 209 ny Carbama Promecarb 2631-37-O ##### 4092 ny Carbama Propoxur 114-26-1 478O2 62 ny Carbama Propoxur, other related NA 1073 NA. 161 90062 ny Carbama Terbutol S419 388O1 51 ny Carbama Thiocarboxime 25171-63-5 ##### NA 156 ny Carbama Thiofanox 391.96-18-4 ##### 2938 insecticide ny Carbama Trimethacarb 12407-86-2 ##### 2962 insecticide, ny Carbama Molluscicide, Dog and Cat Repellen Trimethacarb, (2,3,5)- 26SS-15-4 ##### NA 882 insecticide, N-Me ny Carbama component of Molluscicide Trimethacarb, (3,4,5)- 2686-99-9 ##### NA 881 insecticide, N-Me ny Carbama component of Molluscicide 26SS-14-3 NA. 176 NAS4 insecticide N-Me ny Carbama Xylylcarb 190572 NA. 176 NASS insectici N-Me ny Carbama Aldrin 309-00-2 4S101 9 insectici Organoc orine Aldrin, other related NA 1069 NA. 160 90009 insectici Organoc orine alpha-BHC 319-84-6 NA 200 767 insectici Organoc orine Arochlor (composition 12767-79-2 178O3 NA. 161 NA Organoc orine unspecified, PCBs and/or PCTs) Aroclor 1336-36-3 178O1 5003 NA Organoch orine Bandane 8O29-29-6 2O3O1 S4 insecticide Organoch orine BHC (other than gamma NA1092 NA. 162 90359 insectici e Organoch orine isomer) HC, beta isomer 319-85-7 NA. 175 NA46 insectici Organoc orine hlordane 57-74-9 S82O1 130 insectici Organoc orine hlordane, other related NA 1075 NA. 161 901.30 insectici Organoc orine hlordane, technical 12789-03-6 S82O2 NA477 insectici Organoc orine hlordecone 143-50-0 27701 347 insectici Organoc orine hlorendic Acid 115-28-6 NA228 NA228 NA Organoc orine DD 72-54-8 29.101 30O2 insecticide Organoc orine DD 6088-31-3 NA 415 184 Breakdown Organoc orine product DD, other related NA 108O NA. 161 90184 Breakdown Organoch orine product D DE 72-55-9 NA 129 2092 Breakdown Organoch orine product DDT SO-29-3 292O1 186 insecticide Organoch orine Dicofol 115-32-2 1OSO1 346 insecticide Organoch orine Dieldrin 60-57-1 4SOO1 210 insecticide, Organoch orine Breakdown product Dieldrin, other related NA 1085 NA. 162 90210 insecticide Organoch orine Dienochlor 2227-17-0 275O1 468 insecticide Organoch orine Dioxin (2,3,7,8-TCDD) 1746-01-6 ##### 4O68 impurity Organoch orine US 2006/0276339 A1 Dec. 7, 2006 19

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Dioxin (other than 2,3,7,8- NA. 1319 NA177 NA. 176 impurity Organoc hlorine TCDD) Endosulfan 115-29-7 794O1 259 insecticide Organoc orine Endosulfan I (alpha) 959-98-8 794O2 NA 771 insecticide Organoc orine Endosulfan II (beta) 33213-65-9 79403 4046 insecticide Organoc orine Endosulfan sulfate 1031-07-8 794O4 4047 Breakdown Organoc orine product Endrin 72-20-8 416O1 262 insecticide, Organoc hlorine Endrin aldehyde 7421-93-4 NA 156 4069 Organoc hlorine

Endrin ketone S3494-70-5 416O1 5029 Organoc hlorine Endrin, other related NA1086 NA. 162 90262 Organoc hlorine Heptachlor 76-44-8 448O1 317 Organoc hlorine Heptachlor epoxide 1024-57-3 448O1 4O73 Organoc hlorine Heptachlor, other related NA 1089 NA. 162 90.317 Organoc hlorine Hexachloro dibenzo-p-dioxin 34465-46-8 ##### 2587 impurity Organoc hlorine Hexachlorobenzene 118-74-1 61001 321 Microbiocide, Organoc hlorine Fungicide, insecticide Hexachlorocyclohexane 608-73-1 89.01 NA 20 insecticide Organoc hlorine Hexachlorocyclopentadiene 77-47-4 275O2 NA 21 insecticide Organoc hlorine Hexachlorodibenzofuran (as 55684-94-1 ##### NA. 161 Organoc hlorine impurity) Sodrin 465-73-6 NA. 208 NA2O7 Organoc hlorine Kelevan 4234-79-1 NA. 208 NA2O8 Organoc hlorine Lindane S8-89-9 9001 359 Organoc hlorine

Methoxychlor 72-43-5 34001 384 Organoc hlorine Methoxychlor, other related NA 1093 NA. 162 90384 Organoc hlorine Mirex 238S-85-S 392O1 402 Organoc hlorine Nonachlor 3734-49-4 448O2 5448 Organoc hlorine Oxychlordane 273O4-13-8 NA177 NA177 Organoc hlorine Oxychlordane, mix of isomers 2688O-48-8 NA177 NA177 Organoc hlorine

Strobane 8001-SO-1 204O1 553 Organoc orine Toxaphene 8001-35-2 8OSO1 594 Organoc hlorine trans-Nonachlor 39765-80-5 NA177 NA177 Organoc hlorine (E)-Mevinphos 298-01-1 158O2 NA143 Organop OSOS (Z)-Mevinphos 338-45-4 158O3 NA 144 Organop OSOS 2,5-dichloro-alpha 2701-86-2 ##### NA116 Organop OSOS (chloromethylene)benzyl diethyl phosphate 2,5-dichloro-alpha S723-62-6 ##### NA116 insecticide Organop OSOS (dichloromethylene)benzyl diethyl phosphate Acephate 30S60-19-1 ##### 1685 insecticide Organop OSOS Acethion 919-54-0 ##### NA. 139 insecticide Organop OSOS Acetoxon 2425-25-4 ##### NA. 139 insecticide, Organop OSOS Breakdown product Akton 1757-18-2 84901 1421 insecticide Organop OSOS Akton, other related NA 1131 NA166 91421 insecticide Organop OSOS alpha,alpha-Dithiol bis(O,O- 2782-70-9 ##### NA1SO NA Organop OSOS dimethyl phosphorodithioate)toluene Amidithion 919-76-6 596O1 NA 487 insectici Organo OS OS Amiton 78-53-5 573O2 NA473 insectici Organo OS OS Amiton oxalate 3734-97-2 57301 NA472 insectici Organo OS OS Anilofos 64249-01-0 NA2O2 NA2O1 insectici Organo OS OS Athidathion 19691-8O-6 ##### NA. 141 insectici Organo OS OS AZamethiphos 35575-96-3 ##### NA 111 insectici Organo OS OS Azethion 72348-92-6 ##### NA. 139 insectici Organo OS OS AZinphos-ethyl 2642-71-9 S80O2 4053 insectici Organo OS OS AZinphos-methyl 86-5O-O S8OO1 314 insecticide Organo OS OS AZinphos-methyl oxygen NA 1057 NA. 157 4054 Breakdown Organo OSOS analog product US 2006/0276339 A1 Dec. 7, 2006 20

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemica

Azothoate 5834-96-8 ##### NA 118 insecticide Organo OS OS Bensulide 741-58-2 98O1 70 Herbicide Organo OS OS Bomyl 122-10-1 842O1 77 insecticide Organo OS OS Bromophos 2104-96-3 87O6 NA 106 insecticide Organo OS OS Bromophos-ethyl 4824-78-6 ##### NA 122 insecticide Organo OS OS Butamifos 3633S-67-8 NA2O2 NA2O1 Herbicide Organo OS OS Butathiofos 90338-20-8 ##### 2433 insecticide Organo OS OS Butonate 126-22-7 35701 255 NA Organo OS OS Cadusafos 95465-99-9 ##### NA14 insecticide Organo OS OS Carbophenothion 786-19-6 S8102 110 insecticide Organo OS OS hlorethoxyphos 54.593-83-8 ##### S106 insecticide Organo OS OS hlorfenvinphos 470-90-6 841O1 306 insecticide Organo OS OS hlormephos 24934-91-6 ##### NA 136 insecticide Organo OS OS hlorphoxim 14816-20-7 NA2O7 NA2O6 insecticide Organo OS OS hlorprazophos 36145-08-1 ##### NA 136 insecticide Organo OS OS hlorpyrifos 2921-88-2 S9101 253 insecticide, Organo OS OS Nematicide orpyrifos oxygen analog S598-15-2 S9101 SO34 insecticide, Organop OS OS Breakdown product hlorpyrifos-methyl S598-13-0 S9102 2468 insecticide Organo OS OS hlorthion SOO-28-7 345O1 NA300 insecticide Organo OS OS hlorthiophos 21923-23-9 ##### 2469 insecticide Organo OS OS hlorthiophos 6O238-56-4 ##### NA919 insecticide Organo OS OS hlorthiophos II 77SO3-29-8 ##### NA918 insecticide Organo OS OS hlorthiophos III 77503-28-7 ##### NA917 insecticide Organo OS OS cis-AZodrin 919-44-8 S8902 NA482 insecticide Organo OS OS cis-Methocrotophos 69632-93-5 ##### NA143 insecticide Organo OS OS Coumaphos 56-72-4 36SO1 16S insecticide Organo OS OS Coumaphos, other related NA 1077 NA. 161 9016S insecticide Organo OS OS Coumithioate S72-48-5 ##### NA. 141 insecticide Organo OS OS Crotoxyphos 7700-17-6 S88O1 140 insecticide Organo OS OS Crotoxyphos, other related NA 1076 NA. 161 90140 insecticide Organo OS OS Cyanofenphos 13067-93-1 ##### NA131 insecticide Organo OS OS Cyanophos 2636-26-2 ##### NA131 insecticide Organo OS OS Cyanthoate 3734-95-O ##### NA131 insecticide Organo OS OS Cythioate 115-93-5 595O1 NA486 insecticide Organo OS OS DDVP 62-73-7 84001 187 insecticide, Organo OS OS Breakdown product DDVP, other related NA1081 84001 901.87 insecticide Organop OS OS Demephion-O 682-80-4 ##### NA143 insecticide, Organop OS OS Breakdown product Demephion-S 2587-90-8 ##### NA143 insecticide Organop OS OS Demeton 8065-48-3 576O1 566 insecticide, Organop OS OS Nematicide Demeton-O 298-03-3 576O2 NA474 insecticide Organo OS OS Demeton-O-methyl 867-27-6 58703 NA48O insecticide Organo OS OS Demeton-S 126-75-0 57603 NA475 insecticide Organo OS OS Demeton-S-methyl 919-86-8 NA 200 NA 200 insecticide Organo OS OS Demeton-S-methyl (mixture) 8022-OO-2 58701 4063 insecticide Organo OS OS Demeton-S-methyl sulfone 17040-19-6 NA 183 NA 182 Breakdown Organo OS OS product, insecticide Dequest 2010 phosphonate NA579 NA 105 2496 NA Organo OS OS Dialifor 10311-84-9 ##### 1799 insecticide Organo OS OS Dialifor, other related NA 1138 NA. 167 91799 insecticide Organo OS OS Diamidafos 1754-58-1 ##### NA879 insecticide, Organo OS OS Nematicide Diazinon 333-41-5 57801 198 insecticide Organop OS OS Diazoxon 962-58-3 NA 156 4064 Breakdown Organop OS OS product Dichlofenthion 97-17-6 614 insecticide, Organop OS OS Nematicide Dicrotophos 141-66-2 3S2O1 72 insecticide Organo OS OS Dimethoate 60-51-5 3SOO1 216 insecticide Organo OS OS Dimethoate-ethyl 116-01-8 ##### NA. 147 insecticide Organo OS OS Dioxabenzofos 3811-49-2 ##### NA112 insecticide Organo OS OS Dioxathion 78-34-2 378O1 192 insecticide Organo OS OS Dioxathion, other related NA 1083 NA. 161 90.192 insecticide Organo OS OS US 2006/0276339 A1 Dec. 7, 2006 21

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Chemica

Diphenprofos S901O-86-5 ##### NA920 Organo OS OS Disulfoton 298-04-4 32SO1 230 Organo OS OS

Disulfoton sulfone 216746 ##### NA 140 Organo OS OS Disulfoton sulfoxide 216777 ##### NA 140 Organo OS OS

Ditalimfos 5131-24-8 ##### NA891 Organo OS OS DMCP 3309-87-3 ##### NA 119 Organo OS OS Edifenphos 17109-49-8 ##### 1964 Organo OS OS Endothion 3.1931.5 ##### NA. 146 Organo OS OS PBP 3792-59-4 ##### NA 155 Organo OS OS PN 2104-64-5 418O1 263 Organo OS OS hephon 16672-87-0 998O1 1626 Organo OS OS

hion 563-12-2 268 Organo OS OS hion, O-analog 17356-42-2 NA478 Organo OS OS

E noprop 13194-48-4 41101 404 Organo OS OS

S840-95-9 ##### NA149 Organo OS OS ester of O,O-dimethyl hosphorodithioate hyl hydrogen 1 21921-96-0 ##### NA148 NA Organo OS OS ropylphosphonate trimfos 38260-54-7 ##### NA. 147 insecticide Organo OS OS Famphur 52-85-7 S9901 282 insecticide Organo OS OS Famphur, O-analog 96.O-25-8 S9902 NA491 Breakdown Organo OS OS product Fenamiphos 22224-92-6 ##### 1857 insecticide, Organo OS OS Nematicide Fenamiphos Sulfone 31972-44-8 NA 156 4070 Breakdown Organo OS OS product Fenamiphos sulfoxide 31972-43-7 NA 156 4O71 Breakdown Organo OS OS product Fenitrothion 122-14-5 ##### 252O insecticide Organo OS OS Fensulfothion 115-90-2 32701 181 Organo OS OS

Fenthion SS-38-9 53301 63 Organo OS OS

Fenthion oxon 3254-63-5 ##### NA143 Organo OS OS

Fonofos 944-22-9 41701 254 Organo OS OS Formothion 2540-82-1 ##### Organo OS OS Fosmethilan 83733-82-8 NA. 208 Organo OS OS Fospirate 5598-52-7 ##### Organo OS OS Fosthiazate 98886-44-3 ##### Organo OS OS Fosthietan 21548-32-3 ##### NA928 Organo OS OS

Heptenophos 23560-59-0 ##### Organo OS OS Hexylthiofos 41495-67-4 ##### Organo OS OS odofenfos 18181-70-9 ##### Organo OS OS probenfos 26087-47-8 NA2O3 Organo OS OS PSP 1432970 NA. 208 Organo OS OS SaZopnos 42509-80-8 ##### Organo OS OS SaZophos-methyl 42509-83-1 ##### Organo OS OS Socarbophos 24353-61-5 ##### Organo OS OS sochlorthion 2463-84-5 345O2 NA301 Organo OS OS Sofephos 253.11-71-1 ##### 2194 Organo OS OS Sothioate 36614-38-7 NA. 208 NA2O7 Organo OS OS Soxathion 18854-01-8 578O2 NA476 Organo OS OS Leptophos 21609-90-5 ##### 1676 Organo OS OS Leptophos, other related NA 113S NA. 167 91676 Organo OS OS Lythidathion 2669-32-1 ##### NA. 147 Organo OS OS Malaoxon NA 1054 NA 156 4O76 Organo OS OS

Malathion 121-75-S 57.701 367 Organo OS OS Mecarbam 2595-54-2 ##### NA 140 Organo OS OS Mecarphon 291.73-31-7 ##### NA 156 Organo OS OS Menazon 78-57-9 ##### NA134 Organo OS OS Mephosfolan 950-10-7 ##### NA131 insecticide Organo OS OS US 2006/0276339 A1 Dec. 7, 2006 22

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemica

Merphos 74901 293 Defoliant, Plant Organo OS OS Growth Regulator Merphos, other related NA 1088 NA. 162 90293 Defoliant, Plant Organo OS OS Growth Regulator Merbofos 3568-56-7 ##### NA 129 NA Organo OS OS Methacrifos 626.10-77-9 NA 189 NA 188 insecticide Organo OS OS Methamidophos 10265-92-6 ##### 1697 insecticide, Organo OS OS Breakdown product Methidathion 950-37-8 ##### 1689 insecticide Organo OS OS Methidathion OA NA 1065 ##### 5040 insecticide Organo OS OS Methyl paraoxon 950-35-6 535O2 4083 Breakdown Organo OS OS product Methyl parathion 298-00-0 535O1 Organo OS OS

Methyl parathion, other related NA1094 NA. 162 Organo OS OS

Methyl phenkapton 3735-23-7 ##### NA142 Organo OS OS Methyl trithion 953-17-3 S8101 3531 Organo OS OS Methyl-carbofenthion NA843 NA. 157 4057 Organo OS OS 7786-34-7 158O1 48O Organo OS OS hos (stereochemistry 26718-6S-O NA 200 NA 200 Organo OS OS unspecified) Mevinphos, other related NA 1103 NA. 163 90480 insectici Organo OS OS Miral 42509-80-8 ##### 2689 insectici Organo OS OS Monocrotophos 6923-22-4 S8901 52 insectici Organo OS OS Morphothion 144-41-2 ##### NA143 insectici Organo OS OS Nale 300-76-5 344O1 418 insectici Organo OS OS Naphthalophos 1491-41-4 ##### NA117 insectici Organo OS OS O.O.S-Trimethyl 2953-29-9 ##### NA. 161 Organo OS OS phosphorodithiate (as impurity) O,O-diethyl O 2668-92-0 ##### NA. 138 insecticide Organo OS OS naphthaloximido phosphorothioate O,O-diethyl phosphoro 226542 NA338 2508 insecticide Organo OS OS chloridothionate O,O-Diethyl S-(4,6-dimethyl 333-40-4 ##### NA 140 insecticide Organo OS OS 2-pyrimidinyl) phosphorodithioate O,O-diethyl-O-phenyl 32345-29-2 NA337 2507 insecticide Organo OS OS phosphorothioate O,O-dimethyl S-(2- 2674-91-1 58704 NA481 insecticide Organo OS OS (ethylsulfinyl)-1-methylethyl) phosphorothioate O-(2-chloro-4-nitrophenyl) O 328-04-1 ##### NA 137 NA Organo OS OS isopropyl ethylphosphonothioate O-(4-Nitrophenyl) O-phenyl 266S-30-7 ##### NA. 158 NA Organo OS OS methylphosphonothioate | O-(4- 2703-13-1 ##### NA117 NA Organo OS OS (methylthio)phenyl) methylphosphonothioate O-Ethyl S-(4-methylphenyl) 333-43-7 ##### NA149 NA Organo OS OS ethylphosphonodithioate O-Methyl 2-nitro-4-tolyl ##### NA. 157 NA Organo OS OS isopropylphosphoramidothioate Omethoate 1113-02-6 3SOO2 2285 Insecticide, Organo OS OS Breakdown product Oxydemeton-methyl 3O1-12-2 58702 382 Insecticide Organo OS OS Paraoxon 311-45-S NA1SS 4082 Breakdown Organo OS OS product Parathion 56-38-2 459 Insecticide Organo OS OS Parathion 56-38-2 NA174 Insecticide, Organo OS OS Nematicide Parathion, other related NA1099 NA. 163 90459 Insecticide, Organo OS OS Nematicide Phenkapton 2275-14-1 ##### NA. 139 Insecticide Organo OS OS Phenthoate 25318O ##### NA 889 Insecticide Organo OS OS US 2006/0276339 A1 Dec. 7, 2006 23

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Chemica

Phorate 298-02-2 478 Organo OS OS

Phorate sulfone 249924 NA1SS Organo OS OS

Phorate sulfoxide 24.9892 NA1SS 4085 Organo OS OS

Phoratoxon NA1SS 4086 Organo OS OS

Phoratoxon sulfone NA 1051 NA1SS 4087 Organo OS OS

Phoratoxon sulfoxide 24995S NA1SS 4088 Organo OS OS

Phosalone 2310-17-0 479 Organo OS OS Phosalone OA NA 1066 SO41 Organo OS OS

Phosfolan 947-02-4 NA131 Organo OS OS Phosmet 732-11-6 335 Organo OS OS hoSmetOXOn 3735-33-9 4089 Organo OS OS

hoSnichlor S826-76-6 34503 NA302 Organo OS OS hosphamidon 13171-21-6 182O1 482 Organo OS OS hosphamidon, other related NA1104 NA. 163 90482 Organo OS OS hostebupirim 96.182-53-5 ##### 5122 Organo OS OS hoxim 14816-18-3 ##### NA. 159 Organo OS OS hoxim-methyl 14816-1 6-1 ##### NA. 159 Organo OS OS Piperophos 24151-93-7 NA219 NA218 Organo OS OS Pirimiphos ethyl 23SOS-41-1 ##### 2781 Organo OS OS Pirimiphos ethyl, O-analog 36378-61-7 ##### NA899 Organo OS OS

Pirimiphos-methyl 29232-93-7 ##### 2217 Organo OS OS Primidophos 392.47-96-6 ##### NA 127 Organo OS OS Profenofos 41198-08-7 ##### 2042 Organo OS OS Propaphos 7292-16-2 NA2O1 NA2O1 Organo OS OS Propetamphos 31218-83-4 ##### 2122 Organo OS OS Propoxon 5823-13-2 ##### NA. 139 Organo OS OS Prothidathion 2O276-83-9 ##### NA. 141 Organo OS OS Prothiofos 34.643-46-4 ##### 4094 Organo OS OS Prothion 5969-94-8 ##### NA. 139 Organo OS OS Prothoate 2275-18-5 ##### NA 140 Organo OS OS Pyraclofos 77458-01-6 NA 183 NA 182 Organo OS OS Pyrazophos 13457-18-6 ##### NA149 Organo OS OS Pyridiphenthion 119-12-0 533O2 NA 450 Organo OS OS Quinallphos 13593-03-8 ##### NA. 145 Organo OS OS Quinallphos-methyl 13593-08-3 ##### NA. 145 Organo OS OS Quinitofos 1776-83-6 ##### NA149 Organo OS OS Quinothion 22439-40-3 ##### NA 140 Organo OS OS Ronnel 299-84-3 S8301 517 Organo OS OS S.S.S-tributyl 78-48-8 748O1 190 Organo OS OS phosphorotrithioate

S-(1,1-Dimethylethyl) O-ethyl 83318-76-7 ##### NA 104 Organo OS OS ethylphosphonothioate S-(4-(1,1- 329-21-5 ##### NA143 insecticide Organo OS OS dimethylethyl)phenyl) O-ethyl ethylphosphonodithioate Sophamide 37O32-15-8 ##### NA 144 insectici Organo OS OS Sulfotep 3689-24-5 795O1 558 insectici Organo OS OS Sulfotep, other related NA 1111 NA. 164 90558 insectici Organo OS OS Sulprofos 354OO-43-2 ##### 2006 insecticide Organo OS OS Sulprofos oxon 38.527-90-1 ##### NA 12S Breakdown Organo OS OS product Temephos 3383-96-8 insecticide Organo OS OS Temephos sulfoxide 1721O-SS-8 NA483 Breakdown Organo OS OS product TEPP 107-49-3 796O1 577 insecticide Organo OS OS Terbufos 13071-79-9 ##### 2925 insecticide, Organo OS OS Nematicide Terbufos sulfone ##### NA 140 Breakdown Organo OS OS product US 2006/0276339 A1 Dec. 7, 2006 24

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use T ype Chemica

Terbufos sulfoxide 10548-10-4 ##### NA 140 Breakdown Organop OS phorus product Tetrachlorvinphos 22248-79-9 83702 305 SCC icide Organop OS phorus Tetrachlorvinphos 961-11-5 83701 NA34 SCC icide Organop OS phorus Thiometon 640-15-3 ##### NA149 SCC icide Organop OS phorus Thionazin 297-97-2 324O1 2939 SCC icide Organop OS phorus Thionazin, O-analog 7359-55-9 32402 NA297 SCC icide, Organop OS phorus Breakdown product Tolclofos-methyl S7018-04-9 ##### NA 106 Fungicide Organop OS phorus Triazophos 24017-47-8 ##### 3543 SCC icide Organop OS phorus Trichlorfon 52-68-6 57901 88 SCC icide Organop OS phorus Trichloronat 327-98-0 ##### SOO1 SCC icide Organop OS phorus Vamidothion 2275-23-2 ##### 3544 SCC icide Organop OS phorus 3-iodo-2-propynyl butyl SS4O6-53-6 ##### 1938 Fungicide, Other Car 88 carbamate Woo Preservative 6-Methyl-2-propyl-4- 2532-49-2 ##### NA. 157 NA O her Car 88 pyrimidinyl dimethylcarbamate Alanycarb 831.30-01-2 NA. 175 NA47 SCC icide her Car 88 ASulam 3337-71-1 ##### 5076 Herbicide her Car 88 ASulam, Sodium salt 2302-17-2 ##### 1746 Herbicide her Car 88 Benfuracarb 82560-54-1 ##### NA48 SCC icide her Car 88 Chlorbufam 1967-16-4 ##### NA. 157 Herbicide her Car 88 Chlorprocarb 23121-99-5 ##### NA 136 Herbicide her Car 88 Chlorpropham 101-21-3 18301 141 Herbicide, her Car 88 Plant Growth Regulator Diethofencarb 871.30-20-9 NA 184 NA 183 Fungicide her Car 88 Dimetan 122-15-6 ##### NA112 insecticide her Car 88 Dimetilan 644-64-4 90101 NA 844 insecticide her Car 88 Fenoxycarb 791.27-8O-3 ##### 2283 insecticide, her Car 88 insect Growth Regulator Fenoxycarb 72490-01-8 NA228 NA228 insecticide, O her Car 88 insect Growth Regulator Solan ##### NA 155 insecticide her Car 88 Karbutilate 974O1 691 Herbicide her Car 88 Mecarbinizid ##### NA. 157 NA her Car 88 Nitrilacarb ##### NA 129 insecticide her Car 88 Potassium asulam ##### NA893 Herbicide her Car 88 Propamocarb ##### 2147 Fungicide her Car 88 Propamocarb hydrochloride ##### 4022 Fungicide her Car 88 Propham 476O1 339 Herbicide, her Car 88 Plant Growth Regu ator Pyrolan 87-47-8 ##### NA. 157 SCC icide Other Car 88 Swep 918-18-9 846O1 4098 NA Other Car 88 Chlorfeinapyr 224.53-73-0 ##### 3938 SCC icide Pyrazole Pyrazoxyfen 71561-11-0 NA 189 NA 189 Herbicide Pyrazole Tebufenpyrad 19168-77-3 90102 NA 845 SCC Cl Pyrazole (+-)-cis,trans-Deltamethrin 2O71O-23-8 ##### NA 120 SCC ici Pyre hroi (+-)-cis-Permethrin S2341-33-0 ##### NA 120 SCC ici Pyre hroi (S)-Cypermethrin 66841-24-5 ##### 3866 SCC ici Pyre hroi 6-chloropiperonyl 2,2- 70-43-9 ##### NA 124 SCC ici Pyre hroi dimethyl-3-(2- methylpropenyl)cyclopropanecarboxylate Acrinathrin 101007-06-1 ##### NA 4 SCC ici Pyre hroi Alethrin S84-79-2 4001 12 SCC ici Pyre hroi Alethrin Coil NA1163 4002 NA. 163 SCC ici Pyre hroi Alethrin, other related NA 1070 NA. 160 90012 SCC ici Pyre hroi B-fenvalerate 66267-77-4 ##### NA903 SCC ici Pyre hroi Beta-cyfluthrin 68359-37-5 ##### 3956 SCC ici Pyre hroi Bifenthrin 82657-04-3 ##### 2300 SCC ici Pyre hroi Bioresmethrin 28434-01-7 978O2 NA 855 SCC ici Pyre hroi Cismethrin 35764-59-1 97804 NA857 SCC ici Pyre hroi Cyclethrin 97-11-0 4052 NA 69 NA Pyre hroi Cycloprothrin 63935-38-6 NA204 NA2O3 SCC ici e Pyre hroi Cyfluthrin 68359-37-5 ##### 2223 SCC icide Pyre hroi Cyhalothrin 68O85-85-8 ##### NA 104 SCC icide Pyre hroi US 2006/0276339 A1 Dec. 7, 2006 25

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Cypermethrin (stereochemistry S2315-07-8 ##### NA172 insecticide Pyrethroi unspecified) Cypermethrin, alpha 67375-30-8 ##### NA 120 insectici Pyrethroi Cypermethrin, beta 65731-84-2 ##### 2171 insectici Pyrethroi Cypermethrin, theta 71697-59-1 NA 200 NA 199 insectici Pyrethroi Cyphenothrin 39515-40-7 ##### 3885 insectici Pyrethroi D-Alethrin 42534-61-2 40OS 2293 insectici Pyrethroi D-allethrin, other related NA 1151 NA168 92.293 insectici Pyrethroi D-cis-trans Alethrin 42534-61-2 40OS NA. 163 insectici Pyrethroi D-trans Alethrin 28.057-48-9 4003 4038 insectici Pyrethroi D-trans allethrin, other related NA 1154 NA173 94038 insectici Pyrethroi Deltamethrin 52918-63-5 97805 3010 insectici Pyrethroi Deltamethrin (isomer S2820-00-5 ##### NA 120 insectici Pyrethroi unspecified) Deltamethrin, other related NA 1153 NA. 169 93010 insectici Pyrethroi Dimethrin 70-38-2 34101 NA299 insectici Pyrethroi Empenthrin (1R)-isomers 544O6-48-3 NA2O2 NA2O2 insectici Pyrethroi Esbiothrin 28434-OO-6 4004 4040 insectici Pyrethroi Esfenvalerate 66230-04-4 ##### 2321 insectici Pyrethroi Fenpropathrin 39515-41-8 ##### 2234 insectici Pyrethroi Fenpropathrin 642S7-84-7 NA2O1 NA 200 insectici Pyrethroi Fenvalerate S1630-58-1 ##### 1963 insectici Pyrethroi Fenvalerate S1630-58-1 ##### NA173 insectici Pyrethroi Fenvalerate, other related NA1143 NA. 167 91963 insectici Pyrethroi Flucythrinate 701.24-77-5 ##### 2168 insectici Pyrethroi Flumethrin 6977O-45-2 NA219 NA218 insectici Pyrethroi Fluvalinate (stereochemistry 694O9-94-5 ##### 2195 insectici Pyrethroi unspecified) Furethrin 17080-02-3 ##### NA1SO insectici Pyrethroi Halfenprox 111872-58-3 NA 189 NA 188 insectici Pyrethroi miprothrin 72963-72-5 4OO6 5327 insectici Pyrethroi Lambda cyhalothrin 91465-08-6 ##### 2297 insectici Pyrethroi Permethrin 52645-53-1 ##### 2008 insectici Pyrethroi Permethrin, other related NA 1146 NA168 92008 insectici Pyrethroi Phenothrin 26OO2-8O-2 69005 2093 insectici Pyrethroi Phenothrin, other related NA 1147 NA168 92.093 insectici Pyrethroi Prallethrin 23O31-36-9 ##### 3985 insectici Pyrethroi Pyrethrins and pyrethroids, 68648-44-2 69.007 NA 611 insectici Pyrethroi manufg. Residues Resmethrin 10453-86-8 978O1 2119 insectici Pyrethroi Resmethrin, other related NA 1148 NA168 92119 insectici Pyrethroi S-Bioallethrin 28434-OO-6 4004 4039 insectici Pyrethroi Tau-fluvalinate 102851-06-9 NA2O1 NA 200 insectici Pyrethroi Tefluthrin 79538-32-2 ##### 3839 insectici Pyrethroi Tetramethrin 7696-12-0 69003 1695 insectici Pyrethroi Tetramethrin, other related NA 1137 NA. 167 91.695 insectici Pyrethroi Trailomethrin 66841-25-6 ##### 2329 insectici Pyrethroi Transfluthrin 11871 2-89-3 NA206 NA205 insecticide Pyrethroi (Poly-N-acetyl-D- 9012-76-4 ##### 2792 Plant Growth Anima erive glucosamine)-protein Regulator, Fungicide Ammoniated caseinate 90OS-42-9 NAS39 3579 NA Anima erive Androsterone 53-41-8 ##### NA 101 Deer Repellent Anima erive Animal gland extracts NA 63 NA 118 1345 Rodenticide Anima erive Animal glue NA792 NA. 147 3581 Rodenticide, Anima erive Bird Repellent Beef fat NA 637 NA117 3585 Bait Anima erive Bone meal NAS84 NA 106 3589 NA Anima erive Bone oil 8001-85-2 108O1 78 Dog and Cat Anima erive Repellent Calcium salts of casein and Soy NA 665 NA 123 1252 NA Anima erive Casein 9000-71-9 NA. 152 1075 NA Anima erive Cat food NA796 NA. 147 3602 Bait Anima erive Cheese NA222 NA 429 3604 Bait Anima erive Chitin 1398-61-4 ##### NA109 Nematicide Anima erive Clam shells NA797 NA. 147 3611 NA Anima erive Cod liver oil 8001-69-2 31.609 2250 NA Anima erive Dried blood 68911-49-9 611 1315 Dog and Cat Anima erive Repellent Dry milk solids NA149 NA284 1976 NA Anima erive Egg shells NA. 141 NA275 3649 NA Anima erive US 2006/0276339 A1 Dec. 7, 2006 26

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemica Class Eggs NA 802 NA 148 3648 NA Anima erive Elanco empty gelatin capsules NA142 NA 276 2543 NA Anima erive Fish meal NA 123 NA 237 2571 NA Anima erive Fish oil 8O16-13-5 ##### 3658 Adjuvant, Deer Anima erive Repel ent, Dog and Cat Repel ent Game repellent NA1490 NA 221 NA221 Deer Repellent Anima erive Gardol 137-16-6 174 3210 Dog and Cat Anima erive Repel ent Gelatin 9000-70-8 NA 222 3660 insecticide Anima erive Gelatin capsules, R. P. Scherer NAS74 NA 104 2577 NA Anima erive Hydrolyzed proteins NA 1355 NA 192 NA 192 Bait Anima erive Jaguar NA76 NA 147 2146 Deer Repellent Anima erive Lard 61789-99-9 NA 143 3675 NA Anima erive Lion waste NAS71 NA 103 1301 Deer Repellent Anima erive Meat NAS3 NA 1OO 3681 Bait Anima erive Meat meal NAS70 ##### 3682 Bait, Deer Anima erive Repel ent, Dog and Cat Repel ent Meat scraps NAS4 NA O1 3683 Bait Anima erive Meat stock, Hormel #6 NA 618 NA 12 2670 Bait Anima erive Milk 8049-98-7 NA 64 3564 NA Anima erive Nutria meat NA24 NA 36 3702 Bait Anima erive Oil of mink NA 10 NA14 1961 NA Anima erive Oyster shells NA 808 NA 49 3714 NA Anima erive Pig tasties NAS94 NA O7 3730 NA Anima erive Powdered gelatin NA 760 NA 37 2827 NA Anima erive Putrescent whole egg Solids S1609-S2-0 ##### 1935 nSecticide, Anima erive Deer Repellent Shellac 9000-59-3 NA 09 3378 NA Anima erive Silkworm pupae NA 464 NA 828 2855 NA Anima erive Sodium caseinate 9005-46-3 NA 836 3389 NA Anima erive Sperm oil 8002-24-2 99701 NA868 NA Anima erive Whey NAS60 NA 3825 NA Anima erive Wool NAS66 NA 3826 NA Anima erive (-)-.alpha-Cubebene 17699-14-8 ##### NA 130 Insecticide Botanica (7S)-Hydroprene 65733-18-8 ##### NA 107 Insect Growth Botanica Regul ator

1-naphthaleneacetamide 86-86-2 S6001 422 Plant Growth Botanica s (NAD) Regul ator Naphthalene acetic acid derivati 2-methoxy-5-nitro phenol, 67233-85-6 ##### 5117 Plant Growth Botanica Sodium salt Regul ator 2-Naphthyloxyacetamide NA 1401 NA 97 NA 196 Plant Growth Naphthalene acetic Regul ator, acid derivati, Herbicide Botanica 3,7-dimethyl-6-octanol 106-22-9 2140 Insect Botanica Repellent 3,7-dimethyl-6-octen-1-ol 2522 Insect Botanica acetate Repellent Acacia 2591766 2346 NA Botanica Alfalfa NA 635 3569 NA Botanica Alfalfa meal NA393 3570 NA Botanica Algin 90OS-38-3 3571 NA Botanica Almond hulls NA28O 3577 NA Botanica Almond shells NA 636 3578 NA Botanica Alpha-ionone 127-41-3 1518 Dog and Cat Botanica Repellent Alpha-pinene polymer 31393-98-3 NA 53 3996 Insecticide Botanica Amycol potato alpha starch NA272 NA 527 2387 NA Botanica Apple pomace NA262 NA 517 3582 NA Botanica Avermectin 71751-41-2 ##### 2254 Insecticide Botanica Avermectin B1 65195-55-3 ##### NA. 16S Insecticide Botanica Avermectin, other related NA 1156 NA 74 922S4 Insecticide Botanica Azadirachtin 11141-17-6 ##### 2328 Insecticide, Botanica Nematicide Azadirachtin B 95S07-03-2 ##### NA 989 Insecticide Botanica Balsam peru NA 660 NA 22 1146 NA Botanica Barley straw NA873 NA 60 S138 NA Botanica US 2006/0276339 A1 Dec. 7, 2006 27

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Beeswax (yellow and white) NA 245 NA494 3586 NA anica Beet powder NA 246 NA495 3587 NA anica Beta-caryophyllene 87-44-5 NA439 2.188 NA anica Beta-pinene polymer 68240-09-5 NA. 153 3998 insecticide anica Bran NA638 NA117 3590 NA anica Bread crumbs NA 793 NA. 147 3591 Bait anica Buffalo gourd root powder NA238 NA475 3928 NA anica Calfs Milk Replacer NA 1320 NA177 5741 NA anica Canary seed NAS83 NA 105 3597 Bait anica Capsicum oleoresin 404-86-4 70701 470 insecticide anica Cardboard NA795 NA. 147 3599 NA anica Carrageenan 2591943 NA437 3600 Adjuvant anica Carrots NA226 NA438 36O1 NA anica Chlorophyllin 11OO6-34-1 NA 191 NA 190 Fungicide, rganic-Copper, Microbiocide anica Cinerin I 25402-06-6 69009 NA 612 insecticide anica Cinerin II 121-20-0 69.010 NA 613 insecticide anica Cinnamaldehyde 104-55-2 40SO6 2277 Dog and Cat anica Repellent, Fungicide, Dog and Cat Repellen Cinnamon NA217 ##### 36O7 insecticide anica cis-Zeatin NA. 1342 NA 191 NA 190 Plant Growth anica Regulator Citronellal 106-23-0 NA 223 NA 223 nSect anica Repellen Citronellol 106-22-9 NA306 2139 insecticide anica Citrus extract NA. 1457 NA 216 NA215 NA anica Citrus meal NA214 NA407 3608 NA anica Citrus pectin NA215 NA 4.08 3609 NA anica Citrus pulp NA 216 NA 4.09 3610 NA anica Clarified hydrophobic extract 80O2-65-1 2SOO6 3979 insecticide anica of neem oil Clarified hydrophobic neem oil 80O2-65-1 25007 NA172 insecticide anica Cloves, Crushed NA962 ##### 2333 insecticide anica Coco shell flour NA 200 NA392 3617 NA anica Cocoa NA2O7 NA398 3613 NA anica Cocoa shells NA 640 NA117 3614 NA anica Coffee grounds NAS81 NA 105 3619 NA anica Components of etheric oils of NA 1360 NA 193 NA 192 Insecticide anica plant origin Cork NA798 NA. 147 3622 NA anica Corn NA879 NA. 169 5144 Bait anica Corn cobs NA 193 NA383 3624 NA anica Corn flour NA 799 NA. 147 3625 NA anica Corn gluten meal 66O71-96-3 ##### 2481 Herbicide anica Corn product, hydrolyzed NA710 NA 130 2322 Herbicide anica Cotton NA 188 NA376 3629 NA anica Cotton fibre cord NA 189 NA377 2482 NA anica Cottonseed flour 12751-36-9 NA 129 2O78 NA anica Cottonseed meal NA 190 NA378 3630 NA anica Cracked oats NA8O1 NA148 3632 Bait anica Cracked wheat NA 192 NA380 3633 Bait anica Creosote, wood 8021-39-4 2SOO2 NA2O2 Woo anica Preservative Cube extracts NA958 71004 756 insecticide Bo anica Cytokinin 525-79-1 ##### 2082 Plant Growth Bo anica Regulator Cytokinin (as kinetin) 525-79-1 ##### NA172 Plant Growth Bo anica Regulator Daphne oil NA 1354 NA 192 NA 192 SCC Bo anica Repellent Derris resins other than NA 1260 71001 NA172 insecticide Bo anica roteinOne Desmodium NA 1560 NA227 NA227 insecticide Bo anica Digitalis 71-63-6 970O2 NA 850 NA Bo anica Digitalis 1339-93-1 970O2 NA 851 NA Bo anica Dihydroazadirachtin 108.189-58-8 ##### 3994 insecticide, Bo anica Nematicide US 2006/0276339 A1 Dec. 7, 2006 28

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class DMN 571-58-4 5067 Plant Growth Botanical Regulator Douglas fir bark, ground NA 156 NA292 3647 NA Botanical Emamectin, benzoate 137512-74-4 ##### 4020 insecticide Botanical Ethylene glycol ether of pinene 53404-49-2 42101 NA363 insecticide Botanical Eugenol 97-53-0 ##### 2095 Pheromone, Botanical Fragrance, Dog and Cat Repellent, insecticide, SCC Repellent Fenugreek NA 121 NA 234 3657 NA Botanical Flour NA 120 NA232 3659 NA Botanical Flowers of Chamomile NA 1267 ##### NA173 insecticide Botanical (Matricaria chamomilla andfor Anthemidis nobilis) Folic acid 59-30-3 NA 191 NA 190 Plant Growth Botanical Regulator Garlic 8OOO-78-0 ##### 2213 insecticide Botanical Geraniol 106-24-1 ##### 309 Pheromone, Botanical Fragrance, insecticide, SCC Repellent, Dog and Cat Repellent Gibberellic acid, 2-butoxyethyl NA371 Plant Growth Bo anica ester Regulator Gibberellin A4 mixt. With ##### NA952 Plant Growth Bo anica gibberellin A7 Regulator Gibberellins 77-06-5 43801 310 Plant Growth Bo anica Regulator Gibberellins, potassium salt 125-67-7 43802 771 Plant Growth Bo anica Regulator Grape pomace NA 880 NA. 169 S145 NA Bo anica Griseofulvin 126-07-8 ##### NA1SO NA Bo anica Ground corn cobs NA 732 NA 133 2583 NA Bo anica Ground oats NA 804 NA148 3664 Bait Bo anica Ground rice hulls NA 108 NA 212 2584 NA Bo anica Ground sesame plant NA109 ##### 2585 insecticide, Bo anica Nematicide Guar gum 9000-30-0 NA 103 3666 Adjuvant Bo anica Gum resins 9000-75-3 994O1 NA 866 Adjuvant Bo anica Gum Thus 2244967 845O2 NA 834 Adjuvant Bo anica Gum tragacanth 9000-65-1 NA213 3.218 Adjuvant Bo anica Hearts of corn flour NA573 NA 104 3667 NA Bo anica Hellebore alkaloids 1399-70-8 2001 NA 65 NA Bo anica Humic acid 1415-93-6 NA134 2597 NA Bo anica Hydroprene 41096-46-2 ##### 2244 insect Growth Bo anica Regulator Indole 120-72-9 2SOOO 2614 insecticide, Bo anica SCC Repellent, Dog and Cat Repellent Indole-3-acetic acid 87-51-4 ##### NA 106 Plant Growth Botanical Regulator Jasmolin I 4466-14-2 69.011 NA614 insecticide Botanical Jasmolin II 1172-63-0 69.012 NA 615 insecticide Botanical Juniper tar oil 2231543 672O3 NA575 insecticide Botanical Juniperus communis ext. 84603-69-O 67212 NAS82 insecticide Botanical Larkspur alkaloid 41710-20-7 22O2 NA 66 NA Botanical Leaves of Eucalyptus NA 1277 ##### NA174 insecticide Botanical Leaves of Pennyroyal (Mentha NA 1278 ##### NA174 insecticide Botanical pullegium) Lignin NA73 NA 140 2640 NA Botanical Lilacin 118-34-3 67.006 NA573 NA Botanical US 2006/0276339 A1 Dec 7, 2006 29

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Linalool 78-70-6 ##### 2239 insecticide, Botanica nSect Repellent, Fragrance Locust bean gum NA738 NA134 2647 Adjuvant Botanica Medicated feed NA644 NA 118 3685 NA Botanica Millet seed NA38 NA 65 3692 Bait Botanica Mint Herbs NA 128O ##### NA174 insecticide Botanica Montok pepper NA 851 NA. 158 SO12 insecticide Botanica Myrica cerifera, extract 84929-34-O ##### NA 123 NA Botanica N6-Benzyladenine, mixt. with S3663-71-1 ##### NA953 Plant Growth Botanica Gibberellins A4 and A7 Regulator NAA 86-87-3 56002 423 Plant Growth Naphthalene acetic Regulator acid derivati, Botanica NAA, ethyl ester 2122-70-5 S6008 749 Plant Growth Naphthalene acetic Regulator acid derivati, Botanica Nicotine 54-11-5 56702 75 insecticide Botanica Nicotine sulfate 6S-30-5 56703 430 insecticide Botanica NOA 120-23-0 556O1 432 Plant Growth Naphthalene acetic Regulator acid derivati, Botanica Nonanoic acid 112-05-0 ##### 2739 Herbicide, Botanica Fungicide Oatmeal NA 806 NA149 3704 Bait Botanica Oats NA. 16 NA26 3705 Bait Botanica Oil of cedarwood 8000-27-9 40SOS 1011 insecticide, Botanica Fungicide Oil of hardwood NA. 675 672O1 1639 Microbiocide Botanica Oil of pine tar 2227495 67002 2246 insecticide, Botanica Microbiocide Oils, cedarwood, Texan 68990-83-O 11524 NA 118 insecticide, Botanica Fungicide Onion extract NA. 1349 NA 192 NA19 1 NA Botanica Onions NA 807 NA149 3711 NA Botanica Orange pulp NA9 NA13 3712 NA Botanica p-Menthane-3,8-diol 42822-86-6 11550 5255 nSect Botanica Repellent Paloja 9000-28-6 ##### NA 880 NA Botanica Papain 9001-73-4 NA149 3717 Rodenticide Botanica Paper NAS98 NA 107 3718 NA Botanica Paprika NA383 NA 692 3719 NA Botanica Peanut butter NA373 NA 681 2735 Bait Botanica Peanut shells NA375 NA 683 3723 NA Botanica Peanuts NA374 NA 682 3533 Bait Botanica Peat moss NA 809 NA149 3724 NA Botanica Pecan shell flour NA376 NA684 3725 NA Botanica Pectin 9000-69-5 NA 118 3726 NA Botanica Pepper NA. 1348 NA 192 NA 191 insecticide, Botanica Deer Repellent Peppermint NA365 NA 668 2332 insecticide, Botanica Fragrance Phenylethyl propionate 122-70-3 ##### 2094 Fragrance, Botanica Pheromone, insecticide, SCC Repellent, Dog and Cat Repellen Pine oil 2227495 67002 485 insecticide, Botanical Microbiocide Pine soap NA 1032 NA 127 1993 insecticide, Botanical Microbiocide Pine tar 8O11-48-1 1574 insecticide, Botanical Microbiocide Pine tar oil 91995-59-4 67205 NA576 insecticide, Botanical Microbiocide Pinene 80-56-8 67004 21.87 insecticide Botanical Pinene 1330-16-1 67001 NAS72 insecticide Botanical US 2006/0276339 A1 Dec. 7, 2006 30

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Plant carbolineums NA. 1454 NA215 NA215 Insecticide, Botanical Fungicide Plant extract (derived from NA917 ##### 5453 Nematicide Botanical Quercus falcata, Opuntia indheimeri, Rhus aromatica, and Rhizophoria mangle issues) Polymerized pinene NA399 NA722 2043 insecticide anica Potatoes NA436 NA 786 3772 NA anica Poultry feed NA437 NA 787 3773 NA anica Pyrethrin coils NA1165 69004 NA. 164 insectici anica Pyrethrin I 121-21-1 NA213 NA213 insectici anica Pyrethrin II 121-29-9 69006 NA 610 insectici anica Pyrethrins 8003-34-7 69001 510 insectici anica Pyrethrins, other related NA1108 NA. 164 90S10 insectici anica Pyrethrum narc NA 1 OOO 69000 1461 insectici anica Pyrethrum powder other than 8003-34-7 690O2 NA. 164 insectici anica

NA 450 NA 806 3778 insecticide anica 68990-67-O NA1SO 3779 NA anica NA647 NA 119 378O Bait anica Red dog flour NA452 NA811 37.82 NA anica Red pepper NA 107 70703 1094 Dog and Cat anica Repellen Red Squill glycoside SO7-60-8 708O1 S1.4 Rodenticide anica Repellants (by Smell) of animal NA 1373 NA 194 NA 193 Dog and Cat anica or plant origin Repellent, Deer Repellen Resins, oleo-, capsicum 8O23-77-6 70704 NA 665 insecticide anica Rice NA812 NA1SO 3.783 NA anica Rice hulls NA813 NA1SO 3784 NA anica Rosemary NA 453 ##### 2331 NA anica Rosin 9014-63-5 NA812 3785 NA anica Rosin oil 8002-16-2 40508 NA341 NA anica Rosin, partially dimerized NA454 NA813 3786 NA anica Rosin, partially hydrogenated 65997-06-0 NA1SO 3787 NA anica Rotenone 83-79-4 71003 S18 insecticide anica Rotenone, other related NA1109 NA. 164 90518 insecticide anica Rubber 2594O48 NA814 3788 NA anica Ryanodine NA 1305 715O2 NA. 175 insecticide anica Ryanodine alkaloid 15662-33-6 715O1 520 insecticide anica Rye flour NA648 NA 119 3789 NA anica Sabadilla alkaloids 224,518O 22O1 521 insecticide anica Safrole 94-59-7 97901 3376 NA anica Saponin 8047-15-2 97.004 5033 NA anica Sawdust NA 1306 ##### 1316 Adjuvant anica Scratch feed NA 649 NA 119 3792 NA anica Sea-algae extract NA 1352 NA 192 NA 191 Plant Growth anica Regulator, Adjuvant Seaweed NA814 NA1SO 3793 NA anica Sodium 2-nitrophenoxide 824-39-5 ##### S118 Plant Growth anica Regulator Sodium 4-nitrophenoxide 824-78-2 ##### S119 Plant Growth anica Regulator Sorghum, grain NA478 NA 882 3904 NA anica Soy flour NA482 NA 886 3.809 NA anica Soy protein NA483 NA 887 3810 NA anica Soybean extract NA 1353 NA 192 NA 191 NA anica Soybean hulls NA481 NA 885 3807 NA anica Soybean meal NA817 NA1SO 3808 NA anica Squalane 111-01-3 45503 2887 NA anica Sugarbeet meal NA499 NA910 3813 NA anica Sunflower seeds NA 650 NA 119 3815 Bait anica Synthetic vegetable gums 9004-64-2 NA921 1835 Adjuvant anica Tall oil 8002-26-4 67211 2912 Adjuvant anica Tall oil acids 61790-12-3 NA 124 1389 Adjuvant anica Tar oils, from distillation of 8002-29-7 672O2 NAS74 Insecticide, anica wood tar Herbicide Thuringiensin, calcium 23S26-02-5 6404 2941 Insecticide anica technical US 2006/0276339 A1 Dec. 7, 2006 31

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class

Thyme NAS27 ##### 2330 SCC Botanical Repellen insectici Tobacco NA1011 NA959 3932 insectici Botanical Tobacco dust 8O37-19-2 56704 NA 469 insectici Botanical Trimethoxybenzene 135-77-3 40515 SO64 insectici Botanical SCC Repellent, Dog and Cat Repellen Tung oil NAS47 NA997 38.21 NA Botanica Verbenone 1196-01-6 ##### NA 108 SCC Botanica Repellen Walnut flour NA555 NA 101 38.23 NA Botanica Walnut shells, ground NASS6 NA 101 2986 NA Botanica Wheat NA819 NA. 151 3824 NA Botanica Wheat flour NA. 674 NA 12S 1577 NA Botanica White pepper NA 1311 NA178 NA177 insecticide Botanica Wood powder NAS6S NA 102 1463 NA Botanica Wood rosin 224,5031 67208 NA579 NA Botanica Wood tar 91722-33-7 NA577 insecticide Botanica Xanthan gum 11138-66-2 NA 102 2272 Adjuvant Botanica Agrobacterium radiobacter war NA. 1435 NA211 NA 210 Fungicide Micro radiobacter Agrobacterium radiobacter NA 693 NA 127 1984 Fungicide Micro bia Agrobacterium radiobacter NA925 ##### NA. 167 Fungicide Micro bia (strain K84) Agrobacterium radiobacter NA921 6474 5477 Fungicide Micro bia strain K1026 Agrobacterium Vitis NA. 1536 NA 224 NA 224 Fungicide Micro bia Agrotis Segetum granulosis NA. 1391 NA 196 NA 195 insecticide Micro bia virus Ampelomyces quisqualis NA270 NAS25 2385 Micro bia Ampelomyces quisqualis NA 1217 21007 NA. 170 Micro bia isolate M-10 Anagrapha falcifera multi NA862 ##### SO89 Micro bia nuclear polyhedrosis virus (AFMNPV) Aschersonia aleyrodis NA. 1392 NA 196 NA 195 Micro bia Bacillus cereus strain UW85 NA 1218 ##### NA. 170 Micro bia

Bacillus cereus, strain BPO1 NA903 NA172 S183 Micro bia Bacillus popilliae NA257 NASO9 21.83 Micro bia Bacillus popilliae and B. lentimorbus NA 1219 S4SO1 NA. 170 Micro bia Bacillus sphaericus 143447-72-7 ##### 2274 Micro bia Bacillus sphaericus, serotype 143447-72-7 ##### 2409 Micro bia H-5A5B, strain 2362 Bacillus subtilis GBO3 NA 855 ##### 3945 Fungicide Micro bia Bacillus subtilis isolate B246 NA. 1538 NA225 NA 224 Fungicide Micro bia Bacillus subtilis MBI 600 NA 864 ##### S120 Fungicide Micro bia Bacillus subtilis war. NA 1220 648O NA. 170 Fungicide, Micro bia Amyloliquefaciens Strain Plant Growth FZB24 Regulator Bacillus thuringiensis (berliner) 68038-71 6400 86 insecticide Micro bia Bacillus thuringiensis 68038-71 6426 3843 insecticide Micro bia (berliner), Subsp. Aizawai, GC 91 protein Bacillus thuringiensis 68038-71 6400 3856 insecticide Micro bia (berliner), Subsp. Aizawai, serotype H-7 Bacillus thuringiensis 68038-71 3857 insecticide Micro bia (berliner), Subsp. Israelensis, serotype H-14 Bacillus thuringiensis 68038-71 6402 3970 insecticide Micro bia (berliner), Subsp. Kurstaki strain SA-12 Bacillus thuringiensis 68038-71 6402 3858 insecticide Micro bia (berliner), Subsp. Kurstaki, serotype 3a, 3b Bacillus thuringiensis 68038-71 6424 3859 insecticide Micro bia (berliner), Subsp. Kurstaki, strain EG2348 US 2006/0276339 A1 Dec. 7, 2006 32

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemica Name CAS Number Code Code Use T ype Chemica Class

US huringiensis 68038-71-1 6423 3860 SCC ici Micro bia (berliner), Subsp. Kurstaki, EG2371 huringiensis 68038-71-1 6422 3861 SCC ici Micro bia iner), Subsp. Kurstaki, EG2424 huringiensis 68038-71-1 6402 3862 SCC ici Micro bia , Subsp. Kurstaki, SA-11 huringiensis NA148 6400 3863 SCC ici Micro bia , Subsp. Morrisoni, 8a8b. huringiensis 68038-71-1 6400 3864 SCC ici Micro bia Subsp. San Diego huringiensis 68038-71-1 6404 2410 SCC ici Micro bia darstadiensis huringiensis Sub. 68038-71-1 6448 5051 SCC ici Micro bia strain EG7673 coleopteran active toxin US huringiensis Sub. 68038-71-1 6447 SO49 SCC ici Micro bia taki strain EG7673 opteran active toxin huringiensis subsp. NA 1224 6403 NA. 170 SCC ici Micro bia

US huringiensis subsp. 68038-71-1 6402 SOO4 SCC ici Micro bia aki, genetically ineered strain AGRO1 by

US huringiensis subsp. 68038-71-1 6402 5005 SCC ici Micro bia aki, genetically eered strain AGRO2 by

US huringiensis subsp. NA 1232 ##### NA171 SCC ici Micro bia Diego US huringiensis subsp. 68038-71-1 6405 SO43 SCC ici Micro bia brionis US huringiensis subspec. 68038-71-1 NA. 169 3972 SCC ici Micro bia brionis delta endotoxin US huringiensis NA 1234 6476 NA171 SCC ici Micro bia ecies Israelensis strain EG221S Baci US huringiensis 68038-71-1 64O1 4.018 SCC ici Micro bia subs ecies Israelensis, strain PS-78 Baci US huringiensis 68038-71-1 64O7 4024 SCC ici Micro bia subs ecies kurstaki strain BMP

US huringiensis 68038-71-1 6402 SO10 SCC ici Micro bia ecies Kurstaki strain HD pidopteran active toxin huringiensis 68038-71-1 6453 3988 SCC ici Micro bia ecies kurstaki, genetically eered Strain EG7841 opteran active toxin huringiensis var. NA 1238 6445 NA171 SCC ici Micro bia elta endotoxin protein as produced by the Cry1A(c) its controlling sequences Baci lus huringiensis var. 68038-71-1 6452 3978 Insecticide Microbial Kurstaki strain M-200 protein oxin Baci lus huringiensis var. 68038-71-1 6402 3962 Insecticide Microbial Kurs taki, genetically engineered strain ECX 94.41 Bacillus thuringiensis var. 68038-71-1 6459 5325 Insecticide Microbial Kurstaki, genetically engineered strain EG7826 Lepidopteran active toxin US 2006/0276339 A1 Dec. 7, 2006 33

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemica Class Neodiprion sertifer nuclear NA. 1389 NA 196 NA 195 NA Micro bia polyhedrosis virus Nosema locustae spores NA2O ##### 2137 insecticide Micro bia Nuclear polyhedrosis virus NA. 1451 NA215 NA214 insecticide Micro bia Nuclear polyhedrosis virus of NA1430 NA213 NA213 NA Micro bia Helicoverpea zea Nuclear polyhedrosis virus of NA. 1510 NA222 NA222 insecticide Micro bia red-headed pine sawfly Nystatin (streotomyces 1400-61-9 ##### NA 115 NA Micro bia noursei) (withdrawn: 23614-R: pm24) Paecilomyces fumosoroseus NA 831 ##### 3964 insecticide Micro bia apopka strain 97 Paecilomyces Lilacinus Strain NA. 1439 NA213 NA213 insecticide Micro bia 25 Penicillin G, potassium salt NA 666 NA 123 1283 NA Micro bia Peniophora gigantea NA. 1462 NA217 NA 216 Fungicide Micro bia Phlebiopsis gigantea NA. 1388 NA 196 NA 195 Fungicide Micro bia Phytophthora palmivora, NA 860 ##### 5078 Herbicide Micro bia chlamydospores of Polyhedral inclusion bodies of NAS93 ##### 2009 insecticide Micro bia Douglas fir tussock moth nuclear polyhedrosis virus Polyhedral inclusion bodies of NA 1289 ##### NA. 175 insecticide Micro bia gypsy moth nucleopolyhedrosis virus Polyhedral inclusion bodies of NA 1290 ##### NA. 175 insecticide Micro bia N. Sertifer Polyhedral occlusion bodies NA 83S ##### 4028 insecticide Micro bia (OBs) of the nuclear polyhedrosis virus of Helicoverpa zea (corn earworm) Polyhedral occlusion bodies NA 1292 ##### NA. 175 Insecticide Microbial (OBs) of the nuclear polyhedrosis virus of Autographa californica (alfalfa ooper) Polyhedral occlusion bodies NA 830 NA. 153 4007 insecticide Micro bia (OBs) of the nuclear polyhedrosis virus of Spodoptera exigua Polyhedral occlusion bodies of NA 1293 ##### NA. 175 insecticide Micro bia he beet armyworm nuclear polyhedrosis virus Pseudomonas aureofaciens NA 1296 6473 NA. 175 Fungicide Micro bia strain Tx-1 Pseudomonas cepacia type NA449 6419 3926 Fungicide, Micro bia Wisconsin Nematicide Pseudomonas chlororaphis NA902 NA172 S182 Fungicide Micro bia Pseudomonas chlororaphis NA. 1489 6478 NA22O Fungicide Micro bia strain 63-28 Pseudomonas fluorescens EG NA858 6440 5045 Fungicide Micro bia 053 Pseudomonas fluorescens NA 867 6439 3949 Fungicide Micro bia 629RS Pseudomonas fluorescens NA 102O 64.38 2842 Fungicide Micro bia

Pseudomonas fluorescens NA868 642O 3968 Fungicide Micro bia strain NCIB 12089 Pseudomonas Syringae strain NA897 NA171 3950 NA Micro bia AGS31 Psedomonas syringae strain PS31 Pseudomonas Syringae strain NA 836 6451 3967 Fungicide Micro bia ESC-11 Pseudomonas Syringae, strain 686O2-93-7 6411 2824 Fungicide Micro bia 742 RS Pseudomonas Syringae, strain 6858.3-32-4 6441 3960 Fungicide Micro bia ESC-10 US 2006/0276339 A1 Dec. 7, 2006 34

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemica Class Puccinia canaliculata NA 865 ##### 5121. Herbicide Micro bia (Schweinitz) Lagerheim (ATCC #40199) QST 713 strain of dried NA915 6479 5447 Fungicide Micro bia Bacillus subtilis Rabbit Calicivirus NA 1441 NA214 NA 213 Rodent Micro bia Repellent Rhizobium leguminosarum NA 1556 NA226 NA226 Insecticide Micro bia biovar phaseoli Rhizobium leguminosarum NA 1557 NA226 NA226 Insecticide Micro bia viciaeTT 9 Rhizobium meliloti NA 1558 NA227 NA226 Insecticide Micro bia Spinosad 131929-60-7 ##### 3983 insecticide Micro bia Spinosyn D 131929-63-O ##### NA907 Insecticide Micro bia Spores and mycelium spores of NA 1446 NA214 NA 214 Fungicide Micro bia Phlebiopsis gigantea Spores of Bacillus popilliae NA. 1310 S4SO2 NA176 Fungicide Micro bia Spores of Gliocladium NA. 1453 NA215 NA 215 Fungicide Micro bia catenulatum Streptomyces griseoviridis NA875 ##### 3937 Fungicide Micro bia strain K61 Summerfruit tortrix moth NA1491 NA221 NA221 Insecticide Micro bia granulosis virus Tomato mosaic virus NA. 1387 NA 196 NA 195 NA Micro bia Trichoderma harzianum 67892-34-6 ##### NA 106 Fungicide Micro bia (ATCC 20476) Trichoderma harzianum rifai 67892-31-3 ##### 3977 Fungicide Micro bia strain KRL-AG2 Trichoderma harzianum Rifai 67892-31-3 ##### 4016 Fungicide Micro bia strain T-39 Trichoderma polysporum 67892-31-3 ##### NA176 Fungicide Micro bia (ATCC 20475) Trichoderma polysporum rifai NA 1067 NA. 159 S101 NAA Micro bia Verticillium dahliae Kleb. NA. 1386 NA 196 NA 195 Fungicide Micro bia Verticillium lecanii 67892-35-7 6421 NA96 Insecticide Micro bia Xanthomonas campestris pv. NA910 NA174 5317 Herbicide Micro bia Poannua Yeast NA 652 NA 119 3827 NSA Micro bia Allyl isothiocyanate 57-06-7 4901 1010 insecticide Oil - essential Almond, bitter 8013-76-1 NAS46 3576 NAA Oil - essential Aloe vera oil NA918 NA. 175 S4S4 NSA Oil - essential Blend of oils: of lemongrass, of NA1499 NA221 NA221 Insecticide Oil - essential citronella, of orange, of bergamot; geraniol, ionone alpha, methyl salicylate and allylisothioc Camphor 76-22-2 1S602 102 insecticide, Oil - essentia Fungicide, Microbiocide Camphor oil 8008-51-3 1S6O1 NA142 Insecticide, Oil - essentia Fungicide, Microbiocide Canadian balsam 8007-47-4 67209 NA580 Insecticide, Oil - essentia Fungicide Cedar leaf oil 8007-20-3 40507 NA340 Insecticide, Oil - essentia Fungicide Cinnamon oil NA922 NA. 175 5577 NA Oil - essentia Clove oil 8000-34-8 ##### SO18 NSA Oil - essentia Essential oils 8O14-17-3 NA 121 873 insecticide Oil - essentia Eucalyptus oil 8000-48-4 40SO3 281 SCC Oil - essentia Repellent, insecticide Fir needle oil 8021-28-1 ##### NA110 NFA Oil - essentia Lavandin oil 8022-15-9 40SOO 5O17 SCC Oil - essentia Repellent, insecticide, Dog and Cat Repellen Lemon peel oil 8020-19-7 40518 NA346 NFA Oil - essential Lime Oil 8008-26-2 NA213 NA 212 Insecticide Oil - essential US 2006/0276339 A1 Dec. 7, 2006 35

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class

Limonene 138-86-3 79.701 979 SCC Oil - essentia Repellent, insecticide, Dog and Cat Repellen Limonene 138-86-3 79.701 2531 insecticide Oil - essentia Mixture citronella oil, citrus NA1493 NA221 NA221 SCC Oil - essentia oil, eucalyptus oil, pine oil Repellen Oil of ambergis 8O38-65-1 ##### NA 105 NA Oil - essentia Oil of anise 8007-70-3 4301 1051 SCC Oil - essentia Repellent, insecticide, Dog and Cat Repellen Oil of bay 8006-78-8 2O72 NA Oil - essentia Oil of bergamot 8007-75-8 1517 SCC Oil - essentia Repellent, insecticide, Dog and Cat Repellen Oil of black pepper NA. 1521 NA 223 NA 223 insecticide Oil - essentia Oil of cajeput 8008-98-8 40SO4 NA339 NA Oil - essentia Oil of camphor Sassafrassy 8006-8O-2 1S603 897 NA Oil - essentia Oil of chamomile (Matricaria 80O2-66-2 ##### NA 104 insecticide Oil - essentia chamomilla and/or Anthemidis nobilis) Oil of chenopodium 8006-99-3 NA18 1524 NA Oil - essentia Oil of citronella 8000-29-1 21901 143 SCC Oil - essentia Repellent, Dog and Cat Repellen Oil of citrus NA13 NA19 1931 SCC Oil - essentia Repellen Oil of geranium 8000-46-2 ##### 1887 Fragrance Oil - essentia Oi O jasmine 8022-96-6 40SO1 SO63 insecticide Oil - essentia Oil of jojoba 61789-91-1 672OO 3833 insecticide, Oil - essentia SCC Repellent, Fungicide, Dog and Cat Repellen Oil of lavender 8000-28-0 ##### 1888 insecticide Oil - essential Oil of lemon 8008-56-8 NA 120 440 NA Oil - essential Oil of lemongrass S392-40-5 40510 1009 insecticide, Oil - essential Pheromone Oil of lemongrass 22291.07 1136 SCC Oil - essential Repellent, insecticide Oil of mustard 57-06-7 4901 1153 SCC Oil - essential Repellent, insecticide, Dog and Cat Repellen Oil of orange 8008-57-9 40517 441 SCC Oil - essential Repellent, insecticide, Dog and Cat Repellen Oil of pennyroyal 8007-44-1 40509 1325 insecticide Oil - essential Oil of peppermint 8006-90-4 NA 669 2O58 insecticide Oil - essential Oil of rosemary 8000-25-7 ##### 5450 insecticide Oil - essential Oil of rue 8O14-29-7 40519 22O6 NA Oil - essential Oil of spearmint 8008-79-5 ##### 1508 NA Oil - essential Oil of thyme 8007-46-3 ##### NA. 159 NA Oil - essential Oil of wintergreen 119-36-8 766O1 746 insecticide Oil - essential Oils, tea-tree 68647-73-4 28853 NA211 NA Oil - essential Orange pith oil NA. 1461 NA217 NA 216 insecticide Oil - essential Perfume, cherry fragrance oil NA 751 NA 136 2743 Fragrance Oil - essential #493 Phytelene of marigold 70892-20-S ##### NA976 NA Oil - essential Phytelene of marigold 84776-23-8 ##### NA977 NA Oil - essential US 2006/0276339 A1 Dec. 7, 2006 36

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Tansy, sage and lavender NA. 1452 NA215 NA214 Insecticide Oi - essentia extracts Vanillin 121-33-5 ##### S149 NA Oi - essentia Canola oil 120962-03-0 11332 5332 Insecticide, Oi - vege 8. Adjuvant Castor oil 8001-79-4 31608 1013 Rodenticide, Oi - vege Insecticide, Insect Repellent Coconut oil 8001-31-8 ##### NA 124 NA vege Coconut oil monoethanolamine 6814.O-OO-1 691.79 1361 Adjuvant, vege Soap/Surfactant Corn oil 8001-30-7 NA117 3626 NA vege Cottonseed oil 8001-29-4 316O2 101S Insecticide vege 8. Emulsifiable methylated NA907 NA173 S224 Insecticide, vege 8. b e vegetable oil Adjuvant Fir needle oil, siberian 8021-29-2 NA 236 2570 NA vege Hydrogenated castor oil 8001-78-3 31604 3830 Bird Repellent vege Hydrogenated Soybean oil 8O1 6-70-4 NA 186 3670 NA vege Hydrogenated vegetable oils NA 881 NA. 169 S146 NA vege Linseed oil with driers NA 61 NA116 2645 NA vege Linseed oil, boiled 68553-1S-1 NA 115 2644 NA vege Methyl soyate 68919-53-9 NA. 146 3519 Adjuvant vege Oil of inseed 8001-26-1 31603 2248 NA vege Olive oil 8001-2S-O 31 610 3710 NA vege Palm oil NA 749 NA 136 2731 NA vege Peanut oil 22273.15 NA 118 3722 NA vege Plant oils (including rape seed NA 1351 NA 192 NA 191 Insecticide vege oil) Rapeseed oil 80O2-13-9 NA22O NA219 Insecticide vege Safflower oil 8001-23-8 NA 124 1510 NA vege Sesame oil 8008-74-0 724O1 1221 NA vege Soybean oil 8001-22-7 316OS 2335 Insecticide, vege : Adjuvant Vegetable oil 8008-89-7 NA111 1231 Insecticide vege 8. b e Vegetable oil modified NASS2 NA 100 2981 NA vege 8. phenolic resin Vegetable wax 8001-39-6 995O1 1441 NA - vege 8. Weed oil NASS8 NA 101 1694 NA - vege 8. Wheat germ oil NAS59 NA 101 2988 NA - vege 8. (1R-exo)-Brevicomin 2O290-99-7 ##### NA 106 Pheromone Pheromone (4E-7Z)-4,7-Tridecadien-1-yl NA. 1428 NA 199 NA 198 Pheromone Pheromone acetate (4Z-9Z)-7.9-Dodecadien-1-ol NA. 1412 NA 198 NA 197 (OOle (OOle E)-5-decen-1-ol S6578-18-8 78O38 5315 (OOle (OOle E)-10-Dodecenyl acetate 35153-09-4 NA 187 NA 186 (OOle (OOle E)-11-Tetradecenyl acetate 33.189-72-9 ##### 5022 (OOle (OOle E)-2,6-dimethyl-2,6- 141-27-5 NA 21 3307 (OOle (OOle ctadienal E)-4-tridecen-1-yl-acetate 72269-48-8 ##### 2199 (OOle (OOle E)-5-Decenol S6578-18-8 78O38 3974 (OOle (OOle E)-5-Decenyl acetate 38421-90-8 ##### 3975 (OOle (OOle E)-6-dodecenyl acetate 29868-16-4 ##### NA958 (OOle (OOle E)-9-decen-1-ol S6578-18-8 78O38 5071 (OOle (OOle E)-9-dodecen-1-ol, acetate 35148-19-7 ##### 2141 (OOle (OOle E)-9-Tricosene 35857-62-6 NA 200 NA 199 (OOle (OOle E)7-(Z)9-Dodecadienyl NA. 1413 NA 198 NA 197 (OOle (OOle cetate E.Z)-3,13-octadecadien-1-ol 53120-26-6 ##### NA955 Pheromone Pheromone cetate EZ)-8-Dodecenyl acetate NA. 1415 NA 198 NA 197 Pheromone Pheromone R.Z)-5-(1-decenyl) dihydro-2- 64726-91-6 ##### 2096 Pheromone Pheromone (3H)-furanone (Z)-(3,3- 26532-24-1 ##### SO81 Pheromone Pheromone dimethylcyclohexylidene)acetaldehyde (Z)-11-hexadecen-1-ol S6683-54-6 ##### NA971 (OOle (OOle (Z)-11-Hexadecen-1-ol S6683-54-6 NA 193 NA 192 (OOle (OOle (Z)-11-hexadecenal S3939-28-9 ##### 2126 (OOle (OOle (Z)-11-hexadecenyl acetate 60037-58-3 ##### NA 111 (OOle (OOle (Z)-11-Tetradecen-1-yl-acetate 2O711-10-8 NA 199 NA 199 (OOle (OOle (Z)-11-Tetradecenyl acetate 2O711-10-8 ##### 5023 (OOle (OOle US 2006/0276339 A1 Dec. 7, 2006 37

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type C hemical Class

(Z)-13-Octadecanol NA. 1423 NA 199 NA 198 Pheromone (OOle (Z)-13-Octadecenal S8594-45-9 ##### NA 111 Pheromone (OOle (Z)-13-Octadecenyl acetate 34O1O-21-4 ##### 5316 Pheromone (OOle (Z)-2-(3,3-dimethyl cyclo 26S32-23-0 ##### 5079 Pheromone (OOle hexylidene)ethanol (Z)-3-Methyl-6-isopropenyl-9- NA142O NA 198 NA 198 Pheromone (OOle decen-1-yl acetate (Z)-3-Methyl-6-isopropenyl NA. 1419 NA 198 NA 198 Pheromone (OOle 3,4-decadien-1-yl (Z)-4-tridecen-1-yl-acetate 65954-19-0 ##### 2200 (OOle (OOle (Z)-5-Decenyl acetate 67446-07-5 NA 198 NA 197 (OOle (OOle (Z)-5-Dodecen-1-yl acetate 16676-96-3 NA 187 NA 186 (OOle (OOle (Z)-6-dodecenyl acetate 16974-12-2 ##### NA957 (OOle (OOle (Z)-6-Heneicosane-11-one 54844-65-4 ##### NA110 (OOle (OOle (Z)-7-hexadecenal S6797-40-1 ##### NA972 (OOle (OOle (Z)-7-Tetradecanol NA. 1427 NA 199 NA 198 (OOle (OOle (Z)-7-Tetradecenal 6S128-96-3 NA 187 NA 186 (OOle (OOle (Z)-9-dodecenyl acetate 16974-11-1 ##### 2142 (OOle (OOle (Z)-9-hexadecenal 56219-04-6 ##### NA973 (OOle (OOle (Z)-9-tetradecen-1-ol 35153-1S-2 ##### S618 (OOle (OOle (Z)-9-tetradecenal S3939-27-8 ##### 2209 (OOle (OOle (Z)-9-Tetradecenyl acetate 16725-53-4 NA 187 NA 186 (OOle (OOle (Z)-9-Tricosene 27519-02-4 ##### NA 883 (OOle (OOle (Z.E) 7.11-hexadecaclien-1-ol NA 1144 NA168 91997 (OOle (OOle acetate, other related (Z.E)-7.11-hexadecadien-1-yl 516O7-94-4 ##### 1997 Pheromone (OOle 806.80 (Z.E)-7.11-hexadecadien-1-yl S3O42-79-8 ##### NA933 Pheromone (OOle 806.80 (Z.E)-8,10-dodecadienyl NA 1561 NA227 NA227 Pheromone (OOle 806.80 (Z.E)-9,11-Tetradecadien-1-yl 50767-79-8 NA 199 NA 198 Pheromone (OOle 806.80 (Z.E)-9,12-tetradecadienyl 31654-77-O ##### 5617 Pheromone (OOle 806.80 (Z.Z) 7.11-hexadecadien-1-ol NA1145 NA168 91998 Pheromone (OOle acetate, other related (Z.Z.) Octadienyl acetate NA. 1422 NA 199 NA 198 Pheromone (OOle (Z.Z)-11,13-hexadecadienal 71317-73-2 711 5314 Pheromone (OOle (Z.Z)-3,13-octadecadien-1-ol 53120-27-7 ##### NA 954 Pheromone (OOle 806.80 (Z.Z)-7.11-hexadecadien-1-yl S2207-99-5 ##### 1998 Pheromone (OOle 806.80 (Z.Z)-7.11-Hexadecadienyl S2207-99-5 NA 198 NA 197 Pheromone (OOle 806.80 1,7-Dioxaspiro-5,5-undecane 18O-84-7 NA 186 NA 186 (OOle (OOle 1-Methylbutyl decanoate SS195-26-1 ##### NA1OO (OOle (OOle 1-Octen-3-ol 3391-86-4 69037 4029 heromone, (OOle ragrance, nSect Repellent, Dog and Cat Repellent 11-(E)-Tetradecen-1-ol 35153-18-5 ##### S108 (OOle (OOle 11-(Z)-Tetradecen-1-ol 34O10-15-6 ##### NA109 (OOle (OOle 2-cyclopenten-1-one, 2 80-71-7 4049 NA 68 heromone, (OOle hydroxy-3-methyl ragrance 2-methyl-7(R),8(S)-epoxy 298.04-22-6 ##### 216S (OOle (OOle octadecane 3(S)-Methyl-6-isopropenyl-9- NA. 1535 NA 224 NA 224 Pheromone (OOle dodecadien-1-yl acetate 3,7,11-trimethyl-2,6,10 4601-84-O NA983 2269 Pheromone (OOle dodecatriene-1-ol 3-Methyl-2-cyclohexen-1-one 1193-18-6 ##### NA 124 nSect (OOle Repellent, Pheromone 4-(p-acetoxyphenyl)-2- 6093.79 ##### NA 106 Pheromone (OOle butanone 4-Methyl-3-heptanol 14979-39-6 ##### NA962 Pheromone (OOle 7.11-hexadecadien-1-ol, acetate SO933-33-0 ##### NA934 Pheromone (OOle 7,8-Epoxi-2-methyl-octadecane NA. 1417 NA 198 NA 197 Pheromone (OOle US 2006/0276339 A1 Dec. 7, 2006 38

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class 8-dodecene-1-ol, other related NA11SO NA168 92.253 Pheromone Pheromone 9-tetradecen-1-ol, formate, (Z)- S6218-79-2 ##### NA967 Pheromone Pheromone Acetaldehyde.(3,3- 26S32-25-2 ##### SO8O (OOle C (OOle dimethylcyclohexylidene)-(E) beta-Farnesene 18794-84-8 ##### NA110 (OOle (OOle Cis-11-tetradecenyl acetate 2O711-10-8 ##### SO38 (OOle (OOle Distilled cubeb oil 8007-87-2 ##### NA960 (OOle (OOle Dodecadienal NA. 1547 NA226 NA225 (OOle (OOle E.E-8,10-dodecadien-1-ol 33956-49-9 ##### 1851 (OOle (OOle E-3,3-dimethyl-delta,alpha NA951 NA 315 21.93 (OOle (OOle cyclohexane ethanal E-8-dodecene NA. 1532 NA 224 NA 224 (OOle (OOle E-8-dodecenyl acetate 38.363-29-O ##### 2252 (OOle (OOle Farnesol 46O2-84-O ##### 2564 (OOle (OOle Frontalin 284O1-39-0 ##### NA985 (OOle (OOle Frontalin + alpha-pinene 12701-72-3 ##### NA986 (OOle (OOle mixture German cockroach pheromone NA 871 29028 5132 (OOle C (OOle Soamyl acetate 123-92-2 NA. 167 1422 ragrance (OOle Somate LBAM NA. 1438 NA213 NA 212 (OOle (OOle Somate OFM Rosso NA. 1426 NA213 NA 212 (OOle (OOle Lauryl alcohol 112-53-8 1509 2343 heromone, heromone, A.djuvant A.lcohol, Ether Luretape (Grandlure) 11104-05-5 ##### NA923 (OOle (OOle Methyl-trans-6-nonenoate NA. 1421 NA 199 NA 198 (OOle (OOle Multilure 60018-97-5 ##### NA963 (OOle (OOle Multistriatin 59014-03-8 ##### NA961 (OOle (OOle Muscalure 27519-02-4 ##### 1858 (OOle (OOle Myrcene 123-35-3 ##### 21.89 (OOle (OOle Nerolidol 7212-44-4 ##### 2268 (OOle (OOle Nerolidol 7212-44-4 ##### 2701 (OOle (OOle Pentyl valerate 2173-56-O ##### 1809 (OOle (OOle Periplanone B 61228-92-0 ##### 2766 (OOle (OOle Pherodim NA. 1424 NA 199 NA 198 (OOle (OOle Pronumone NA. 1425 NA 199 NA 198 (OOle (OOle Serricornin NA. 1343 NA 191 NA 190 (OOle (OOle Tetradecanal 124-25-4 ##### NA975 (OOle (OOle Trans-11-tetradecenyl acetate 33.189-72-9 ##### 5039 (OOle (OOle trans-6-Nonen-1-ol NA 1404 NA 197 NA 197 (OOle (OOle Trimed lure 12002-53-8 ##### NA 199 (OOle (OOle Z-2-isopropenyl-1-methyl 26S32-22-9 ##### 2190 (OOle (OOle cyclobutane ethanol Z-3,3-dimethyl-delta,alpha NA952 NA316 2.192 Pheromone Pheromone cyclohexane ethanal Z-3,3-dimethyl-delta,beta NA706 NA 129 2191 Pheromone Pheromone cyclohexane ethanol Z-8-dodecene NA. 1531 NA 224 NA 224 Pheromone Pheromone Z-8-dodecenol 4O642-40-8 ##### 2253 Pheromone Pheromone Z-8-dodecenyl acetate 28079-04-1 ##### 2251 (OOle Pheromone 7-(diethyl amino)-4-methyl 91-44-1 NA341 3.146 Ro el Cl e Coumarin coumarin Brodifacoum 56073-10-0 ##### 2049 Ro el ici Coumarin Bromadiolone 2.8772-56-7 ##### 2135 Ro el ici Coumarin Coumachlor 81-82-3 ##### NA 126 Ro el ici Coumarin Coumafuryl 117-S2-2 86001 298 Ro el ici Coumarin Coumafuryl, Sodium salt 34490-93-2 86004 299 Ro el ici Coumarin Coumarin 91-64-5 ##### NA 102 Ro el ici Coumarin Coumatetralyl S836-29-3 ##### NA. 153 Ro el ici Coumarin Difenacoum 56073-07-5 ##### NA970 Ro el ici Coumarin Flocoumafen 90O3S-08-8 NA 182 NA 181 Ro el ici Coumarin Potassium warfarin 2610-86-8 8600S NA 836 Ro el ici Coumarin Pyranocoumarin NA. 1431 NA 199 NA 199 Ro el ici Coumarin Warfarin 81-81-2 86002 621 Ro el ici Coumarin Warfarin, sodium salt 129-06-6 86003 1184 Ro el ici Coumarin 2-isovaleryl 1-1,3-indandione 83-28-3 67702 1435 Ro el ici 1,3-Indandione 2-isovaleryl 1-1,3-indandione, 23710-76-1 67706 1736 Ro el ici 1,3-Indandione calcium salt 2-isovaleryl-1,3-indandione, S3404-57-2 67709 NAS96 Ro el ici 1,3-Indandione Sodium salt Chlorophacinone 3691-3S-8 67707 1625 Ro el ici 1,3-Indandione Diphacinone 82-66-6 67701 225 Ro el ici 1,3-Indandione US 2006/0276339 A1 Dec. 7, 2006 39

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Diphacinone, sodium salt 42721-99-3 67705 636 Rodenticide 1,3-Indandione Pindone 83-26-1 67703 489 Rodenticide 1,3-Indandione Pindone, calcium salt 53404-72-1 67708 NA595 Rodenticide 1,3-Indandione Pindone, sodium salt 6120-20-3 67704 305 Rodenticide, 1,3-Indandione Bird Repellent 4-Hydroxymethyl NA 1173 NA177 NA. 16S Breakdown 2,6-Dinitroaniline pendimethalin broduct Benfluralin 1861-40-1 84301 53 Herbici 2,6-Dinitroaniline Butralin 33629-47-9 ##### 756 Herbici 2,6-Dinitroaniline Dinitramine 29091-05-2 ##### 683 Herbici 2,6-Dinitroaniline Dipropalin 5332 ##### NA. 145 Herbici 2,6-Dinitroaniline Ethal fluralin SS283-68-6 ##### 2166 Herbici 2,6-Dinitroaniline Fluazinam 79622-59-6 ##### 3898 Fungici 2,6-Dinitroaniline Fluchloralin 33245-39-5 ##### 848 Herbici 2,6-Dinitroaniline Flumetralin 62924-70-3 ##### 5085 Plant Growth 2,6-Dinitroaniline Regulator Sopropalin 33820-53-0 ##### 681 Herbicide 2,6-Dinitroaniline N,N-Bis(2-chloroethyl)-4- 26389-78-6 ##### NA135 NA 2,6-Dinitroaniline methyl-2,6-dinitroaniline Nitralin 4726-14-1 376O1 490 Herbici 2,6-Dinitroaniline Oryzalin 19044-88-3 ##### 868 Herbici 2,6-Dinitroaniline Pendimethalin 40487-42-1 ##### 929 Herbici 2,6-Dinitroaniline Prodiamine 29091-21-2 ##### 2236 Herbici 2,6-Dinitroaniline Prodiamine, other related NA1149 NA168 92236 Herbici 2,6-Dinitroaniline Profluralin 26399-36-0 ##### 897 Herbici 2,6-Dinitroaniline Profluralin, other related NA1141 NA. 167 91897 Herbici 2,6-Dinitroaniline Trifluralin 1582-09-8 36101 597 Herbici 2,6-Dinitroaniline 1-(3- S1971-67-6 ##### NA110 NA Carboxamide chlorophthalimido)cyclohexane carboxamide Alidochlor 93-71-0 19301 114 Herbici Ami Alidochlor 2O2-270-7 NA 210 NA 210 Herbici Ami Ammonium benzadox S2S1-79-6 982O1 NA858 Herbici Ami Beflubutamid 113614-08-7 NA 230 NA 230 Herbici Ami Benzadox S2S1-93-4 ##### NA132 Herbici Ami Benzipram 3S256-86-1 ##### NA 133 Herbici Ami Bromobutide 74712-19-9 NA2O3 NA2O3 Herbici Ami e Carboxin 5234-68-4 902O1 1755 Fungici Carboxamide Chlorthiamid 1918-13-4 ##### NA. 139 Herbici Ami Cisanilide 34484-77-0 ##### NA 144 Herbici Carboxamide Cyclafuramide 34849-42-8 ##### NA132 Fungici Carboxamide Cyprazole 42089-03-2 ##### NA132 Herbici Ami e Dimethenamid 87674-68-8 ##### S112 Herbici Ami e Diphenamid 957-51-7 366O1 226 Herbici Ami e Epronaz S9026-08-3 NA. 231 NA. 231 Herbici Ami e Etnipromid 76120-02-0 NA. 231 NA. 231 Herbici Ami e Fenfuram 24691-8O-3 NA 188 NA 187 Fungici Carboxamide FentraZamide 158237-07-1 NA232 NA. 231 Herbici Ami Flupoxam 119126-15-7 NA 188 NA 188 Herbici Ami Furmecyclox (Xyligen B) 60S68-05-0 ##### NA18 Fungici Carboxamide Halosafen 77227-69-1 NA 229 NA 229 Herbici Ami e, Nitrophenyl ether Isocarbamide 30979-48-7 NA 183 NA 182 Herbici Ami e Isoxaben 82558-50-7 ##### 2289 Herbici Ami e Methfuroxam 28730-17-8 ##### NA949 Fungici Carboxamide Metsulfowax 21452-18-6 NA 189 NA 188 Fungici Carboxamide Napropamide 15299-99-7 ##### 1728 Herbici Ami Naptalam 132-66-1 30702 2998 Herbici Ami Naptalam, sodium salt 132-6 7-2 30703 437 Herbici Ami Nitrofurazone (not subject to 59-87-O ##### NA128 NA Carboxamide FIFRA: 8709-e pm 24) Oxycarboxin S259-88-1 902O2 1434 Fungicide Carboxamide p-Benzoquinone 61566-21-0 ##### NA 133 NA Carboxamide semicarbazone Pethoxamid 106700-29-2 NA 233 NA 233 Herbicide Amide Propy Zamide 23950-58-5 ##### 694 Herbicide Amide Propy Zamide metabolite NA 1048 NA1SS 4093 Breakdown Amide product Quinonamid 27541-88-4 NA 210 NA. 209 Herbicide Amide 2-Hydroxy alachlor NA943 NA 183 26O2 Breakdown Chloroacetanilide product US 2006/0276339 A1 Dec. 7, 2006 40

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class 3,4,5-tribromo salicylanilide, NA1122 NA. 16S 90833 Microbiocide Anilide other related 3,5-dibromosalicylanilide 2577-72-2 77405 12S6 Microbiocide Anilide 5,4-dibromosalicylanilide NA 1024 NA 122 1071 Microbiocide Anilide Aatram (propachlor with 8070-76-6 8O816 NA 781 Herbicide Triazine, atrazine) (019101 + 080803) Chloroacetanilide Acetochlor 34256-82-1 ##### 2349 Chloroacetanilide Alachlor 15972-60-8 90SO1 678 Chloroacetanilide Benodani 15310-01-7 ##### NA. 154 Anilide Butachlor 23184-66-9 ##### 40S6 Chloroacetanilide Butenachlor 873 10-56-3 NA206 NA2O6 Chloroacetanilide Clomeprop 84496-56-O NA204 NA2O3 Anilide Cyprofuram 69581-33-5 NA 186 NA 18S Anilide Cypromi 2759-71-9 26101 178 Anilide 24353-58-O ##### NA132 Chloroacetanilide 38727-55-8 ##### 1995 e r Chloroacetanilide 83164-33-4 NA 184 NA 183 Anilide SOS 63-36-5 NA 184 NA 183 Chloroacetanilide 79S40-50-4 NA 229 NA228 Anili 78.357-48-9 NA. 231 NA. 231 Anili 1424,59-58-3 ##### 5293 Anili NA 1568 NA 234 NA 234 Anili 66332-96-5 ##### 2305 Anili 732SO-68-7 NA 189 NA 188 Anili S378O-34-O ##### SO82 Anili

Mefluidide, diethanolamine salt S378O-36-2 ##### 1955 Anilide Mefluidide, potassium salt 836O1-83-6 ##### 5083 Anilide Mepronil 55814-41-0 NA 189 NA 188 Anilide Metazachlor 67129-08-2 NA 184 NA 183 Chloroacetanilide Metolachlor 51218-45-2 ##### 1996 Chloroacetanilide Metolachlor, (S) 87392-12-9 ##### 5133 Chloroacetanilide Monalide 7287-36-7 ##### NA134 Anili Naproanilide S2570-16-8 NA 233 NA232 Anili Ofurace 5881O-48-3 NA 189 NA 188 Anili Oxadixyl 77732-09-3 ##### 3539 Anili Perfluidone 37924-13-3 ##### 1895 Anili Perfluidone, diethanolamine NA991 NA. 671 1896 Anili Salt Pretilachlor 51218-49-6 NA 184 NA 184 Chloroacetanilide Propachlor 1918-16-7 19101 511 Chloroacetanilide Propanil 709-98-8 282O1 503 Anilide Propisochlor 86,763-47-5 NA 233 NA 233 Chloroacetanilide Prynachlor 21267-72-1 ##### NA. 138 Chloroacetanilide

Pyracarbolid 24691-76-7 NA 210 NA. 209 Fungicide illide Salicylanilide 87-17-2 774O7 450 Fungicide, illide Microbiocide Sodium salicylanilide 2S1930 ##### NA. 145 Fungicide Anilide Thenylchlor 96491-05-3 NA 229 NA 229 Herbicide Chloroacetanilide Triclocarban 101-20-2 27901 844 NA Aniillide Benzoylprop 222 12-5 6-2 NA 182 NA 181 Herbici anine Benzoylprop ethyl 222 12-SS-1 ##### NA. 147 Herbici anine Benzoylprop-ethyl 33878-SO-1 NA206 NA205 Herbici anine Flamprop S8667-63-3 NA 188 NA 187 Herbici anine Flamprop-isopropyl S2756-22-6 ##### NA. 154 Herbici anine Flamprop-M-isopropyl 57973-67-8 ##### NA. 154 Herbici anine Flamprop-M-methyl 57973-66-7 ##### NA 104 Herbici anine Flamprop-methyl 52756-25-9 ##### NA. 154 Herbici anine Chlorazifop 60074-25-1 NA. 231 NA 230 Herbici oxyphenoxy ropionic acid Clodinafop 114420-56-3 NA 182 NA 182 Plant Growth oxyphenoxy Regulator ropionic acid Clodinafop-propargyl 105512-06-9 ##### NA. 163 Plant Growth oxyphenoxy Regulator ropionic acid Clofop 26129-32-8 NA2O7 NA2O6 Herbicide oxyphenoxy ropionic acid Cyhalofop 122008-78-0 NA204 NA2O3 Herbicide Ary oxyphenoxy propionic acid US 2006/0276339 A1 Dec. 7, 2006 41

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Cyhalofop butyl 122008-85-9 NA215 5748 Herbicide Ary oxy phenoxy propionic aci80 Diclofop 40843-25-2 ##### NA912 Herbicide oxy henoxy propioniC aci Diclofop-methyl S1338-27-3 ##### 2O34 Herbicide oxy henoxy propioniC aci Fenoxaprop-ethyl 82110-72-3 NA2O1 NA 200 Herbicide oxy henoxy (stereochemistry unspecified) propioniC aci Fenoxaprop-P (+) 71283-8O-2 ##### 5123 Herbicide oxy henoxy propioniC aci Fenoxaprop-P (+/-) 66441-23-4 ##### 2311 Herbicide oxy henoxy propioniC aci Fenoxaprop-P-ethyl 113158-40-0 NA22O NA219 Herbicide oxy henoxy propioniC aci Fenthiaprop (racemic) 95721-12-3 NA2O7 NA2O7 Herbicide oxy henoxy propionicC aci Fenthiaprop (unstated 73519-SO-3 NA218 NA217 Herbicide oxyphenoxy stereochemistry) propionic aci Fenthiaprop-ethyl (racemic) 93921-16-5 NA218 NA217 Herbicide oxyphenoxy propionicC aci Fenthiaprop-ethyl (unstated 66441-11-0 NA218 NA217 Herbicide oxyphenoxy stereochemistry) propionicC aci Fluazifop 6933S-91-7 NA 194 NA 193 Herbicide oxy henoxy propioniC aci Fluazifop-butyl 69806-50-4 ##### 2186 Herbicide oxy henoxy propioniC aci Fluazifop-P-butyl 792.41-46-6 ##### NA995 Herbicide oxy henoxy propioniC aci Fluazifop-P-butyl 83066-88-0 NA228 NA228 Herbicide oxy henoxy propioniC aci Haloxyfop (unstated 69806-34-4 ##### NA1OO Herbicide oxy henoxy stereochemistry) propioniC aci Haloxyfop-etotyl (unstated 87237-48-7 NA 200 NA 199 Herbicide oxy henoxy stereochemistry) C acid, Glycol Ethert Haloxyfop-methyl (unstated 690806-40-2 hitfiti NA19 Herbicide henoxy stereochemistry) icC aci Haloxyfop-R 72619-32-0 NA 191 NA 190 Herbicide henoxy propioniC aci Propaquizafop 111479-OS-1 NA 18S NA 184 Herbicide henoxy propioniC aci Quizalofop 76578-12-6 NA 190 NA 189 Herbicide henoxy propioniC aci Quizalofop-ethyl 76578-14-8 ##### 2226 Herbicide henoxy propioniC aci Quizalofop-P 94051-08-8 NA 18S NA 184 Herbicide henoxy propioniC aci Quizalofop-P-ethyl 1 OO646-51-3 NA 212 NA211 Herbicide henoxy propionic aci Quizalofop-p-tefuryl 119738-06-6 NA2O2 NA2O2 Herbicide henoxy propionicC aci Trifop S8594-744 NA 234 NA 233 Herbicide Ary oxyphenoxy propionic aci 2,5-Dichlorobenzoic acid SO-79-3 NA 224 NA 224 Fungicide Benzoic aci 2,5-Dichlorobenzoic acid 290S-69-3 NA 224 NA 224 Fungicide Benzoic aci methyl ester 3,5-dichlorobenzoic acid S1-36-5 NA 156 4066 NA Benzoic aci 4'-hydroxy-m-phenoxybenzoic 35065-12-4 NA. 176 2609 Fungicide, Benzoic aci acid Microbiocide 4-hydroxybenzoic acid 99-96-7 NA 200 NA 199 NA Benzoic aci 5-hydroxy-dicamba NA 840 NA 156 406S Herbicide, Benzoic aci Breakdown product Butyl paraben 94-26-8 612OS NA496 Fungicide, Benzoic aci Microbiocide Chloramben 133-90-4 29901 21.84 Herbicide Benzoic aci Chloramben, ammonium salt 1O76-46-6 299.02 831 Herbicide Benzoic aci Chloramben, ammonium salt, NA1121 NA. 16S 90831 Herbicide Benzoic aci other related Dicamba 1918-00-9 298O1 2OO Herbicide Benzoic aci Dicamba with 2,4-D 8068-77-7 29807 NA219 Herbicide Benzoic aci US 2006/0276339 A1 Dec. 7, 2006 42

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Dicamba with 2,4-D & Silvex 8073-53-8 298O8 NA22O Herbici Benzoic aci Dicamba, aluminium salt NA 1215 ##### NA. 170 Herbici Benzoic aci Dicamba, butoxyethyl ester NA. 1477 NA22O NA219 Herbici Benzoic aci Dicamba, diethanolamine salt 2SO59-78-3 298O3 780 Herbici Benzoic aci Dicamba, diglycolamine salt 104040-79-1 ##### 5007 Herbici Benzoic aci Dicamba, dimethylamine salt 2300-66-5 29802 849 Herbici Benzoic aci Dicamba, dimethylamine salt, NA1123 NA. 16S 90849 Herbici Benzoic aci other related Dicamba, isopropylamine salt SS871-02-8 ##### SO98 Herbici e Benzoic aci Dicamba, methyl ester 6597-78-0 ##### NA. 146 Herbicide Benzoic aci Dicamba, monoethanolamine S3404-28-7 298.04 1829 Herbicide Benzoic aci Salt Dicamba, monoethanolamine NA1140 NA. 167 91.829 Herbicide Benzoic aci salt, other related Dicamba, other related NA 1084 NA. 161 902OO Herbici Benzoic aci Dicamba, potassium salt 10007-85-9 ##### S110 Herbici Benzoic aci Dicamba, Sodium salt 1982-69-O 29806 5057 Herbici Benzoic aci Dicamba, triethanolamine salt 53404-29-8 29805 1113 Herbici Benzoic aci Dichlorobenzoic acid NA1383 NA. 19S NA 194 Fungici Benzoic aci methylester Diethanolamine 3-amino-2,5- 53404-16-3 29904 NA222 Herbicide Benzoic aci dichlorobenzoate Dodecylamine Salicylate 7491-21-6 2003 insecticide, Benzoic aci Fungicide, Microbioci Ethyl paraben 120-47-8 3204 Fungicide, Benzoic aci Microbioci Homosalate 118-56-9 76603 3231 insecticide, Benzoic aci Fungicide, Microbioci Methyl chloramben 7286-84-2 29905 NA 223 Herbicide Benzoic aci Methyl paraben 99-76-3 612O1 1005 Fungicide, Benzoic aci Microbioci Methyl paraben, calcium salt 4O167-95-1 61208 NA499 Fungicide, Benzoic aci Microbioci Methyl paraben, sodium salt SO26-62-O NA498 Fungicide, Benzoic aci Microbioci Monomethylammonium 251 82-03-0 29903 NA221 Herbicide Benzoic aci chloramben (3-amino-2,5- dichlorobenzoic acid) Propyl paraben 94-13-3 2841 Fungicide, Benzoic aci Microbioci Propyl paraben, calcium salt 83542-69-2 NA497 Fungicide, Benzoic aci Microbioci Propyl paraben, sodium salt 3528S-69-9 61.204 NA495 Fungicide, Benzoic aci Microbioci Salicylic acid 69-72-7 1170 insecticide, Benzoic aci Fungicide, Microbioci Sodium 3-amino-2,5- 1954-81-O 2.9906 NA 224 Herbicide Benzoic aci dichlorobenzoate Tricamba 2307-49-5 17301 NA 51 Herbicide Benzoic aci Anisuron 2689-43-2 ##### NA 38 Herbicide Benzoylurea Diflubenzuron 3.5367-38-5 ##### 1992 insecticide Benzoylurea Flucycloxuron 113O36-88-7 ##### NA 09 Herbicide Benzoylurea Flucycloxuron, (E) 94OSO-52-9 NA2O1 NA 200 Herbicide Benzoylurea Flufenoxuron 1O1463-69-8 ##### NA901 insecticide Benzoylurea Hexaflumuron 86479-06-3 ##### 3899 insecticide Benzoylurea Lufenuron 103OSS-O7-8 NA 184 NA 83 insecticide Benzoylurea Novaluron 116714-46-6 NA226 NA226 Herbicide Benzoylurea Phenobenzuron 449.583 ##### NA 33 Herbicide Benzoylurea Teflubenzuron 83121-18-0 ##### NA 33 insecticide Benzoylurea Trifumuron 64628-44-0 ##### 2961 insecticide Benzoylurea Diethamquat chloride NA 1567 NA. 231 NA. 231 Herbicide Bipyridylium Diquat bistribromide 27041-82-3 ##### NA 46 Herbici Bipyridylium Diquat dibromide 85-OO-7 322O1 229 Herbici Bipyridylium Dessicant Diquation 2764-72-9 322O2 NA294 NA Bipyridylium Monolinuron with paraquat 69312-6 7-0 ##### NA 19 Herbicide Urea, Bipyridylium dichloride Morfamquat 7411-47-4 ##### NA 35 NA Bipyridylium US 2006/0276339 A1 Dec. 7, 2006 43

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Morfamquat 7411-47-4 NA2O1 NA 200 Herbicide Bipyridylium Morfamguat chloride 4636-83-3 NA 212 NA 212 Herbicide Bipyridylium Paraquat 4685-14-7 61603 NASOO Herbicide Bipyridylium Paraquat bis(methylsulfate) 2O74-SO-2 616O2 458 Herbicide Bipyridylium Paraquat bistribromide 27041-84-5 ##### NA. 159 Herbicide Bipyridylium Paraquat dichloride 1910-42-5 61601 16O1 Herbicide Bipyridylium Priglone (diquat dibromide 784-03-23-3 32203 NA295 NA Bipyridylium wiparaquation) ,3-Dimethyl-1,1,3,3- 22232-20-8 346O1 NA303 NA Bis-Carbamate disiloxanetetrol-1,3- bis(dimethylthiocarbamate) DeSmedipham 13684-56-5 ##### 1748 Herbicide Bis-Carbamate Dimethyl (4-methyl-1,3- S1543-98-7 ##### NA 888 Fungicide Bis-Carbamate phenylenebis(iminocarbonyl H-benzimidazole-1,2- diyl)biscarbamate Phenisopham 57375-63-0 NA. 209 NA2O8 Herbicide Bis-Carbamate Phenmedipham 13684-63-4 98.701 675 Herbicide Bis-Carbamate Phenmedipham-ethyl 13684-44-1 ##### NA149 Herbicide Bis-Carbamate 2-Hydroxy alachlor NA943 NA 183 26O2 Breakdown Chloroacetanilide broduct Aatram (propachlor with 8070-76-6 8O816 NA 781 Herbicide Triazine, atrazine) (019101 + 080803) Chloroacetanilide Acetochlor 34256-82-1 ##### 2349 Herbici Chloroacetanilide Alachlor 15972-60-8 90SO1 678 Herbici Chloroacetanilide Butachlor 23184-66-9 ##### 40S6 Herbici Chloroacetanilide Butenachlor 873 10-56-3 NA206 NA2O6 Herbici Chloroacetanilide Delachlor 24353-58-O ##### NA132 Herbici Chloroacetanilide Diethatyl-ethyl 38727-55-8 ##### 1995 Herbici Chloroacetanilide Dimethachlor SOS 63-36-5 NA 184 NA 183 Herbici Chloroacetanilide Metazachlor 67129-08-2 NA 184 NA 183 Herbici Chloroacetanilide Metolachlor 51218-45-2 ##### 1996 Herbici Chloroacetanilide Metolachlor, (S) 87392-12-9 ##### 5133 Herbici Chloroacetanilide Pretilachlor 51218-49-6 NA 184 NA 184 Herbici Chloroacetanilide Propachlor 1918-16-7 19101 511 Herbici Chloroacetanilide Propisochlor 86,763-47-5 NA 233 NA 233 Herbici Chloroacetanilide Prynachlor 21267-72-1 ##### NA. 138 Herbici Chloroacetanilide Plant Growth Regulator Thenylchlor 96491-05-3 NA 229 NA 229 Herbicide Chloroacetanilide (2-Methyl-4,6- 13333-87-4 ##### NA. 161 impurity Chlorophenoxy aci dichlorophenoxy)acetic acid O eSer (as impurity) 2,3,6-Trichlorophenylacetic 2903-64-2 82603 NA819 Herbicide Chlorophenoxy aci acid O eSer 2,3,6-Trichlorophenylacetic 53404-91-4 82604 NA82O Herbicide Chlorophenoxy aci acid, sodium salt O eSer 2,4,5-T 93-76-5 82001 639 Herbicide Chlorophenoxy aci O eSer 2,4,5-T tetradecylamine salt 53535-37-8 82013 1989 Herbicide Chlorophenoxy aci O eSer 2,4,5-T, 2-ethylhexyl ester 1928-47-8 82O63 1092 Herbicide Chlorophenoxy aci O eSer 2,4,5-T, alkylamine Salt 53535-37-8 82013 818 Herbicide Chlorophenoxy aci O eSer 2,4,5-T, butoxyethanol ester 2545-59-7 82O53 819 Herbicide Chlorophenoxy aci or ester, Glycol Ethe 2,4,5-T, butoxyethanol ester 2545-59-7 82O72 NA166 Herbicide Chlorophenoxy aci O eSer 2,4,5-T, butoxypropyl ester 1928-48-9 82055 82O Herbicide Chlorophenoxy aci O eSer 2,4,5-T, butyl ester 93-79-8 82O56 822 Herbicide Chlorophenoxy aci O eSer 2,4,5-T, butyric acid 93-8O-1 ##### NA. 152 Herbicide Chlorophenoxy aci O eSer 2,4,5-T, dimethylamine salt 6369-97-7 82019 1474 Herbicide Chlorophenoxy aci O eSer 2,4,5-T, dodecylamine Salt 53404-84-5 82011 1988 Herbicide Chlorophenoxy aci O eSer 2,4,5-T, isooctyl ester 251 68-15-4 NA 121 851 Herbicide Chlorophenoxy aci O eSer US 2006/0276339 A1 Dec. 7, 2006 44

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class

2,4,5-T, N-oleyl-1,3- S3404-87-8 82O29 1097 ter bicide Chlorop henoxy aci propylenediamine Salt O eSer 2,4,5-T, propylene glycol butyl 1928-48-9 82055 824 ter bicide Chlorop henoxy aci ether ester O eSer 2,4,5-T, triethylamine salt 2008-46-0 82O34 850 ter bicide Chlorop henoxy aci O eSer 2,4,5-trichlorophenoxyacetic 69462-12-0 NA 799 ter bicide Chlorop henoxy aci acid, 2-ethyl-4-methylpentyl O eSer ester 2,4,5-trichlorophenoxyacetic 53404-85-6 82012 NA790 ter bicide Chlorop henoxy aci acid, alkyl (C13) amine Salt O eSer 2,4,5-trichlorophenoxyacetic 120-39-8 82051 NA795 ter bicide Chlorop henoxy aci acid, amyl ester O eSer 2,4,5-trichlorophenoxyacetic 1928-58-1 82O52 NA796 ter bicide Chlorop henoxy aci acid, butoxyethoxypropanol O eSer ester 2,4,5-trichlorophenoxyacetic S3404-86-7 82O38 NA 793 ter bicide Chlorop henoxy aci acid, diethylethanolamine salt O eSer 2,4,5-trichlorophenoxyacetic 4938-72-1 82O62 NA798 ter bicide Chlorop henoxy aci acid, isobutyl ester O eSer 2,4,5-trichlorophenoxyacetic 93-78-7 82066 NA 800 ter bicide Chlorop henoxy aci acid, isopropyl ester O eSer 2,4,5-trichlorophenoxyacetic SS256-33-2 82O39 NA794 ter bicide Chlorop henoxy aci acid, N,N-dimethyl oleyl O eSer linoleylamine Salt 2,4,5-trichlorophenoxyacetic 53404-88-9 82037 NA792 ter bicide Chlorop henoxy aci acid, N.N- O eSer dimethyllinoleylamine sal 2,4,5-trichlorophenoxyacetic 53404-89-0 82O20 NA791 ter bicide Chlorop henoxy aci acid, N,N-dimethyloleylamine O eSer Salt 2,4,5-trichlorophenoxyacetic SS491-33-3 82O77 NA803 ter bicide Chlorop henoxy aci acid, pentyl ester O eSer 2,4,5-trichlorophenoxyacetic 13560-99-1 82004 NA 789 ter bicide Chlorop henoxy aci acid, sodium salt O eSer 2,4,5-trichlorophenoxyacetic 53535-32-3 NA 802 ter bicide Chlorop henoxy aci acid, tripropylene glycol O eSer isobutyl ether ester 2,4-D 94-75-7 636 Chlorop henoxy aci O eSer

2,4-D with 2,4,5-T 801S-35-8 30.077 NA 259 Chlorop henoxy aci O eSer 2,4-D, 2-ethyl-4-methylpentyl S3404-37-8 NA227 NA227 ter Chlorop henoxy aci ester O eSer 2,4-D, 2-ethylhexyl ester 1928-43-4 3OO63 1622 ter Chlorop henoxy aci O eSer 2,4-D, alkanolamine salts 2307-55-3 3OOOS ter Chlorop henoxy aci (ethanol and isopropanol O eSer amines) 2,4-D, alkyl (C12) amine salts 2212-54-6 30011 ter bicide Chlorop henoxy aci O eSer 2,4-D, alkyl (C14) amine salts 28685-18-9 30013 981 ter bicide Chlorop henoxy aci O eSer 2,4-D, butoxy ethoxy propanol 1928-57-O 3OOS2 1255 ter bicide Chlorop henoxy aci ester O eSer 2,4-D, butoxyethanol ester 1929-73-3 3.0053 802 ter bicide Chlorop henoxy aci or ester, Glycol Ethe 2,4-D, butoxyethanol ester 1929-73-3 30061 NA166 ter bicide Chlorop henoxy aci O eSer 2,4-D, butoxypropyl ester 1928-45-6 30055 803 ter bicide Chlorop henoxy aci O eSer 2,4-D, butyl ester 94-80-4 300S6 804 ter bicide Chlorop henoxy aci O eSer 2,4-D, chlorocrotyl ester 2971-38-2 NA228 NA227 ter bicide Chlorop henoxy aci O eSer 2,4-D, diethanolamine salt S742-19-8 3OO16 805 ter bicide Chlorop henoxy aci O eSer 2,4-D, diethylamine salt 20940-37-8 875 ter bicide henoxy aci O eSer US 2006/0276339 A1 Dec. 7, 2006 45

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class 2,4-D, dimethylamine salt 2008-39-1 3OO19 806 Herbicide Chlorophenoxy acid or ester 2,4-D, dodecylamine Salt 2212-54-6 30011 807 Herbicide Chlorophenoxy acid or ester 2,4-D, heptylamine Salt 371 O2-63-9 3OO23 1962 Herbicide Chlorophenoxy acid or ester 2,4-D, isooctyl ester 251 68-26-7 3OO64 809 Herbicide Chlorophenoxy acid or ester Triclopyr S5335-06-3 ##### NA36 Herbicide Chloropyridinyl Triclopyr ethyl ester 60825-27-6 ##### NA 108 Herbicide Chloropyridinyl Triclopyr, butoxyethyl ester 64700-56-7 ##### 2170 Herbicide Chloropyridinyl, Glycol Ether Triclopyr, triethylamine salt S7213-69-1 ##### 2131 Herbicide Chloropyridinyl Alloxydim SS634-91-8 NA2O3 NA2O3 Herbicide Cyclohexenone erivative Alloxydim sodium 55635-13-7 ##### NA926 Herbicide Cyclohexenone erivative Butroxydim 138164-12-2 NA2O2 NA2O2 Herbicide Cyclohexenone erivative Clethodim 99129-21-2 ##### 3566 Herbicide Cyclohexenone erivative Cloproxydim 9548O-33-4 NA. 231 NA. 231 Herbicide Cyclohexenone erivative Cycloxydim 1O1205-02-1 NA 184 NA 183 Herbicide Cyclohexenone erivative Sethoxydim 74051-80-2 ##### 2177 Herbicide Cyclohexenone erivative Tepraloxydim 149979-41-9 hithifi NA982 Herbicide Cyclohexenone erivative Tralkoxydim 8782O-88-0 ##### 54.57 Herbicide Cyclohexenone erivative 2,4-dinitrophenol 51-28-5 3.7509 221 impurity Dinitropheno erivative 2,4-dinitrophenol, Sodium salt 1011-73-0 ##### NA. 161 impurity, Dinitropheno (as impurity) Breakdown erivative product 2,4-Dinitrophenylthiocyanate 1594-56-5 ##### NA. 146 NA Dinitropheno erivative 2,6-dinitrophenol, Sodium salt 32581-06-9 ##### NA. 161 impurity Dinitropheno (as impurity) erivative 2-Cyclohexyl-4,6-dinitrophenol 317-83-9 375O2 NA316 NA Dinitropheno dicyclohexylamine 3,3'-Dichloro-5,5'-dinitro-(1,1'- 15595-24-1 ##### NA 137 NA Dinitropheno biphenyl)-2,2'-diol 3,3'-Dichloro-5,5'-dinitro-(1,1'- 63992-31-4 ##### NA 137 NA Dinitropheno biphenyl)-2,2'-diol 4,6-Dinitro-2- 69632-97-9 ##### NA. 145 NA cyclohexylphenol, 2-((2- aminoethyl)amino)ethanol salt 4,6-Dinitro-2- 69632-98-O ##### NA. 145 NA cyclohexylphenol, Eriethanolamine salt 5,5'-Dichloro-3,3'-dinitro-(1,1'- 10331-57-4 ##### NA 137 NA Dinitropheno biphenyl)-2,2'-diol erivative 6,6'-Dichloro-4,4'-dinitro-(1,1'- 21832-25-7 ##### NA 137 NA Dinitropheno biphenyl)-2,2'-diol erivative Binapacryl 485-31-4 122O1 73 Herbicide Dinitropheno erivative Diethanolamine dinoseb (2- 53404-43-6 37514 NA320 Herbicide Dinitropheno sec-butyl-4,6-dinitrophenol) erivative Dinex 131-89-5 375O1 NA 315 NA Dinitropheno erivative Dinitro cresol 534-52-1 37507 3170 Fungicide Dinitropheno erivative Dinitro-1-methylheptyl phenol NA. 159 NA302 758 NA Dinitropheno erivative Dinitrophenol (mixed isomers) 25550-58-7 NA 223 NA 223 Breakdown Dinitropheno product, Impurity Dinobuton 973-21-7 ##### 2526 Insecticide, Dinitropheno Fungicide erivative US 2006/0276339 A1 Dec. 7, 2006 46

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Dinocap 393OO-45-3 36OO1 344 Fungicide, Dinitropheno Insecticide erivative Dinocap, other related NA1091 NA. 162 90344 Insecticide, Dinitropheno Fungicide erivative Dinocton 32534-96-6 NA2O7 NA2O6 Insecticide, Dinitropheno Fungicide erivative Dinofenate 61614-62-8 ##### NA. 146 Herbicide Dinitropheno erivative Dinopenton S386-57-2 ##### NA. 154 NA Dinitropheno erivative Dinoprop 72S7-41-2 ##### NA. 138 NA Dinitropheno erivative Dinosam 4097-36-3 37504 NA318 Dinitropheno erivative Dinoseb 88-85-7 37505 238 Dinitropheno erivative Dinoseb acetate 2813-95-8 NA2O7 NA2O6 Dinitropheno Dinoseb, amine Salt 22443.87 37511 239 Dini tropneno Dinoseb, ammonium salt 636S-83-9 37513 240 Dini tropneno Dinoseb, Sodium salt 35040-03-0 37512 1445 Dini tropneno Dinoseb, triethanolamine salt 6420-47-9 37506 235 Dini tropneno Dinosulfon S386-77-6 ##### NA. 157 Dini tropneno Dinoterb 1420-07-1 ##### NA128 Herbicide Dinitropheno

Dinoterbon 6O73-72-9 ##### NA128 Herbicide DNOC, sodium salt 2312-76-7 37508 533

Etinofen 2544-94-7 ##### NA. 147 Dinitropheno

Medinoterbacetate 212943 NA. 208 NA2O8 Dinitropheno

Methyl 2-(1-methylheptyl)-4,6- S386-68-5 ##### NA. 157 Dinitropheno dinitrophenyl carbonate w Premerge plus (naptalam with 8075-57-8 30704 NA278 Herbicide Dinitrop dinoseb) Sodium naptalam with sodium S991S-53-6 30705 NA279 Herbicide dinoseb w Sultropen 963-22-4 ##### NA. 146 Acifluorfen SO594-66-6 ##### NA935 Herbici henyl ether Acifluorfen, sodium salt 62476-59-9 ##### 2218 Herbici henyl ether Aclonifen 74O70-46-5 NA 187 NA 187 Herbici henyl ether Bifenox 42576-02-3 ##### 1953 Herbici henyl ether Chlomethoxyfen 32861-85-1 NA 18S NA 18S Herbici henyl ether Diofenolan 63837-33-2 7703 NA 101 Herbici henyl ether Ethyl acifluorfen 772O7-01-3 ##### NA936 Herbici henyl ether Fluoroglycofen 77SO1-60-1 NA 181 NA 18O Herbici henyl ether Fomesafen 72178-02-0 ##### NA17 Herbici henyl ether Fomesafen sodium 108731-70-0 ##### SO86 Herbici henyl ether Lactofen 77SO1-63-4 ##### 3.538 Herbici henyl ether Methyl acifluorfen SOS94-67-7 ##### NA937 Herbici henyl ether Oxyfluorfen 42874-03-3 ##### 1973 Herbici henyl ether Bromobonil 2S671-46-9 ##### NA134 Herbici roxybenzonitrile Bromoxynil butyrate 3861-41-4 35303 2163 Herbici roxybenzonitrile Bromoxynil heptanoate 56634-95-8 ##### SO36 Herbici roxybenzonitrile Bromoxynil octanoate 1689-99-2 353O2 834 Herbici roxybenzonitrile Bromoxynil pentanoate NA. 1476 NA22O NA219 Herbici roxybenzonitrile Bromoxynil phenol 1689-84-5 35301 2429 Herbici roxybenzonitrile Chloroxynil 1891-95-8 ##### NA. 138 Herbici roxybenzonitrile Oxynil 1689-83-4 ##### 2616 Herbici roxybenzonitrile oxynil lithium 2961-61-7 ##### NA. 141 Herbici roxybenzonitrile Oxynil octanoate 3861-47-O ##### NA. 141 Herbici roxybenzonitrile US 2006/0276339 A1 Dec. 7, 2006 47

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Ioxynil Sodium 2961-62-8 ##### NA. 141 Herbicide Hydroxybenzonitrile 3-5-(1,1-Dimethylethyl)-3- 78327-32-9 ##### NA 108 Algaecide midazolinone isoxazolyl-4-hydroxy-1- methyl-2-imidazolidinone 3-Pyridinecarboxylic acid, 2 81334-60-3 ##### NA1 Herbicide midazolinone (4,5-dihydro-4-methyl-4-(1- methylethyl)-5-oxo-1H imidazol-2-yl)-5-methyl-, (..+-)- Imazamethabenz 81405-85-8 ##### 2240 midazolinone Imazamox 114311-32-9 ##### NA2 midazolinone Imazapic 104098-48-8 NA 212 NA211 midazolinone Imazapyr 81334-34-1 ##### 2256 midazolinone Imazapyr, isopropylamine Salt 81510-83-0 ##### 2257 midazolinone Imazaquin 81335-37-7 ##### 2613 midazolinone

Imazaquin, ammonium salt 81335-47-9 ##### 3006 midazolinone Imazaquin, Sodium salt 81335-46-8 ##### S109 midazolinone Imazethalpyr 81335-77-5 ##### 2340 midazolinone

Imazethalpyr, ammonium salt 101917-66-2 ##### 2341 midazolinone Pyridine carboxylic acid, 2 104098-49-9 ##### 5097 midazolinone (4,5-dihydro-4-methyl-4-(1- methylethyl)-5-oxo-1H imidazol-2-yl)-5-methyl, monoammonium salt 2O782-58-5 NA. 231 NA 230 Herbici henylurea 42609-52-9 NA204 NA204 Herbici henylurea 33439-45-1 NA232 NA232 Herbici henylurea 42609-73-4 NA205 NA204 Herbici henylurea 27954-37-6 ##### NA. 145 Herbici henylurea 71048-99-2 NA2O2 NA2O1 Herbici hosphinico amino

Ampropylofos 16606-64-7 NA 181 NA 18O Fungici phonic acid Glyphosate 1071-83-6 ##### 2997 Herbici phonoglycine Glyphosate, ammonium salt 114370-14-8 NA228 2319 Herbici hosphonoglycine Glyphosate, diammonium salt NA 1566 NA 229 S810 Herbici phonoglycine Glyphosate, isopropylamine 38641-94-0 ##### 1855 Herbici phonoglycine Salt Glyphosate, monoammonium 114370-14-8 ##### 2301 Herbicide Phosphonoglycine Salt Glyphosate, sodium sesqui salt 70393-85-0 ##### 2275 Herbicide Phosphonoglycine Glyphosate-trimesium 81591-81-3 ##### 2327 Herbicide Phosphonoglycine N,N- 2439-99-8 ##### NA 884 Herbicide Phosphonoglycine Bis(phosphonomethyl)glycine 6-chloropicolinic acid 4684-94-O 692O6 NA657 Herbicide Pyridinecarboxylic aci Clopyralid 1702-17-6 ##### 5135 Herbicide Pyridinecarboxylic aci Copyralid copper NA. 1458 NA 216 NA 216 Herbicide Pyridinecarboxylic aci Copyralid, monoethanolamine 57754-85-5 ##### 5050 Herbicide Pyridinecarboxylic Salt aci Clopyralid, triethylamine salt NA955 ##### 2339 Herbicide Pyridinecarboxylic aci Picloram S145 5101 593 Herbicide Pyridinecarboxylic aci Picloram, alkanolamine Salt NA. 1479 NA22O NA219 Herbicide Pyridinecarboxylic aci Picloram, diethanolamine salt S145 NA22O NA22O Herbicide Pyridinecarboxylic aci Picloram, isooctyl ester 26952-20-S 5103 835 Herbicide Pyridinecarboxylic aci Picloram, potassium salt 2545-60-0 S104 5330 Herbicide Pyridinecarboxylic aci Picloram, triethylamine salt 35832-11-2 5105 NA 77 Herbicide Pyridinecarboxylic aci Picloram, triisopropanolamine 6753-47-5 S102 1099 Herbicide Pyridinecarboxylic Salt aci US 2006/0276339 A1 Dec. 7, 2006 48

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Picolinafen 137641-05-S NA 210 NA 210 Herbici Pyridinecarboxylic aci Thiazopyr 117718-60-2 ##### 3984 Herbici Pyridinecarboxylic aci Amidosulfuron 120923-37-7 NA 183 NA 183 Herbici Sulfonylurea AZimsulfuron 120162-55-2 ##### NA112 Herbici Sulfonylurea Bensulfuron 99283-01-9 NA 181 NA 18O Herbici Sulfonylurea Bensulfuron methyl 83OSS-99-6 ##### 2263 Herbici Sulfonylurea Chlorimuron 99283-OO-8 NA204 NA2O3 Herbici Sulfonylurea Chlorimuron ethyl 90982-32-4 ##### 2458 Herbici Sulfonylurea Chlorsulfuron 64902-72-3 ##### 2143 Herbici Sulfonylurea Cinosulfuron 94593-91-6 NA 183 NA 183 Herbici Sulfonylurea Cyclosulfamuron 3.6849-15-S NA204 NA2O3 Herbici Sulfonylurea EthametSulfuron 11353-84-5 NA 212 NA 212 Herbici Sulfonylurea EthametSulfuron-methyl 97780-06-8 ##### NA43 Herbici Sulfonylurea Ethoxysulfuron 268O1-58-9 NA226 NA225 Herbici Sulfonylurea Flazasulfuron O4040-78-0 NA 229 NA228 Herbici Sulfonylurea Flupyrsulfuron SO315-10-9 NA205 NA204 Herbici Sulfonylurea Flupyrsulfuron-methyl NA. 1460 NA 216 NA 216 Herbici Sulfonylurea Flupyrsulfuron-methyl, sodium 44740-54-5 NA218 NA217 Herbici Sulfonylurea Salt Halosulfuron OO784-20-1 ##### 3919 Herbici Sulfonylurea Imazosulfuron 22548-33-8 NA 229 NA 229 Herbici Sulfonylurea Iodosulfuron methyl 851 19-76-0 NA 212 NA211 Herbici Sulfonylurea Iodosulfuron methyl, Sodium 445SO-36-7 NA 212 NA211 Herbici Sulfonylurea Salt Mesosulfuron-methyl ##### NA993 Herbici Sulfonylurea Metsulfuron NA 183 NA 182 Herbici Sulfonylurea Metsulfuron-methyl ##### 2222 Herbici Sulfonylurea Nicosulfuron 11991-09-4 ##### 3829 Herbici Sulfonylurea Oxasulfuron 44651-06-9 ##### NA991 Herbici Sulfonylurea Primisulfuron-methyl 86209-51-0 ##### 5103 Herbici Sulfonylurea Prosulfuron ##### 5115 Herbici Sulfonylurea Pyrazosulfuron NA205 NA205 Herbici Sulfonylurea Pyrazosulfuron-ethyl NA218 NA217 Herbici Sulfonylurea Rimsulfuron ##### 3835 Herbici Sulfonylurea Sulfometuron NA206 NA205 Herbici Sulfonylurea Sulfometuron methyl ##### 2149 Herbici Sulfonylurea Sulfosulfuron 856O1 S136 Herbici Sulfonylurea Thifensulfuron NA 183 NA 182 Herbici Sulfonylurea Thifensulfuron-methyl ##### 2237 Herbici Sulfonylurea Triasulfuron 82097-SO-5 ##### S100 Herbici Sulfonylurea Tribenuron O6040-48-6 NA206 NA205 Herbici Sulfonylurea Tribenuron methyl O12OO-48-0 ##### 2338 Herbici Sulfonylurea TrifluSulfuron-methyl 26535-15-7 ##### 3875 Herbici Sulfonylurea Tritosulfuron 42469-14-5 NA 234 NA 234 Herbici Sulfonylurea Butylate 41405 565 Herbici hiocarbamate Calcium thylenebis 145O1 NA. 139 Microbiocide Dithiocarbamate (dithiocarbamate) 1096-18-7 NA 181 NA 18O Fungici e Dithiocarbamate 134-23-2 41301 S16 Herbici e hiocarbamate 6O7313 145O2 NA 140 Microbiocide Dithiocarbamate ethylenebis(dithiocarbamate) Dimepiperate 61432-SS-1 NA 186 NA 18S Herbici hiocarbama EPTC 759-94-4 41401 264 Herbici hiocarbama Esprocarb 85785-20-2 NA2O3 NA2O2 Herbici hiocarbama Ethiolate 2941-55-1 ##### 1793 Herbici hiocarbama Fenothiocarb 628SO-32-2 NA 188 NA 187 insectici de hiocarbama Ferbam 14484-64-1 348O1 288 Fungici e Dithiocarbamate Ferric nitroso dimethyl 83542-83-0 ##### NA149 Microbiocide Dithiocarbamate dithiocarbamate Furathiocarb 6S907-30-4 NA. 176 NAS2 insectici de hiocarbamate Isopolinate 3134-70-1 NA232 NA232 Herbici hiocarbamate Mancopper S3988-93-5 NA 181 NA 18O Fungici Dithiocarbamate Mancozeb 22331 OO 14504 211 Fungici Dithiocarbamate, Inorganic-Zinc Maneb 12427-38-2 145OS 369 Fungici Dithiocarbamate Maneb and nickel sulfate 8OOS-46-7 ##### NA. 158 Fungici Dithiocarbamate, hexahydrate (014505 + 050505) Inorganic-Nickel Manganous 15339-36-3 NA 304 Fungici Dithiocarbamate dimethyldithiocarbamate US 2006/0276339 A1 Dec. 7, 2006 49

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Mercuric dimethyl 15415-64-2 348O8 709 Microbiocide Inorganic-Mercury, dithiocarbamate Heavy metal, Dithiocarbamate Metam sodium, dihydrate 137-42-8 39003 NA. 163 Fumigant, Dithiocarbamate Fungicide, Microbiocide, Algaecide, Nematicide Metam-sodium 6734-80-1 39003 616 Fumigant, Dithiocarbamate Herbicide, Fungicide, Microbiocide, Algaecide, Nematicide Methasulfocarb 66952-49-6 NA2O2 NA2O1 Fungicide, Thiocarbamate Plant Growth

Methiobencarb 18357-78-3 NA232 NA232 Thiocarbamate Metiram 90O6-42-2 146O1 493 Fungicide Dithiocarbamate, Inorganic-Zinc Molinate 2212-67-1 414O2 449 Herbicide Thiocarbamate Molinate sulfoxide NA 1052 NA 156 408O Breakdown Thiocarbamate product Morpholinomethyl 31848-11-0 ##### NA. 158 Microbiocide Dithiocarbamate dimethyldithiocarbamate Nabam 142-59-6 14503 417 Fungicide, Dithiocarbamate Herbicide Orbencarb 34622-58-7 NA 189 NA 188 Herbicide Thiocarbamate Pebulate 1114-71-2 41403 590 Herbicide Thiocarbamate Phenylmercuric 324O7-99-1 66008 NA555 Microbiocide, Organomercury, dimethyldithiocarbamate Fungicide Dithiocarbamate, Heavy metal Potassium ammonium 22221-14-3 14507 NA. 141 Microbiocide Dithiocarbanaate ethylenebis(dithiocarbamate) Potassium dimethyl dithiocarbamate 128-03-0 348O3 1934 Microbiocide Dithiocarbamate Potassium N-hydroxymethyl 51026-28-9 ##### 1824 NA Dithiocarbamate N-methyldithio carbamate Potassium N-methyldithiocarbamate 137-41-7 39002 970 Fumigant, Dithiocarbamate Fungicide, Microbiocide, Algaecide, Nematicide Propineb 12071-83-9 ##### NA 155 Fungicide, Dithiocarbamate, Microbiocide Inorganic-Zinc Prosulfocarb 52888-80-9 NA 18S NA 184 Herbicide Thiocarbamate Prothiocarb 19622-08-3 NA 183 NA 182 Fungicide Thiocarbamate Prothiocarb hydrochloride 19622-19-6 NA 200 NA 199 Fungicide Thiocarbamate Pyributicarb 88678-67-5 NA 229 NA 229 Herbicide Thiocarbamate S-tert-Butyl 2212-63-7 ##### NA128 Herbicide Thiocarbamate ipropylthiocarbamate Sodium dimethyl dithiocarbamate 128-04-1 34804 S48 Fungicide Dithiocarbamate Sulfallate 95-06-7 39001 115 Herbicide Dithiocarbamate Tert-butyl dimethyl trithioperoxycarbamate 3304-97-0 34807 1383 Rodent Dithiocarbamate Repellent et NA 1130 NA166 91383 NA Dithiocarbamate butyldimethyltrithioperoxycarbamate, other related Thiobencarb 2824.9-77-6 ##### 1933 Herbicide Thiocarbamate Thiobencarb sulfoxide NA 1042 NA. 139 2937 Breakdown Thiocarbamate product Thiodicarb 59669-26-0 ##### 22O2 Molluscicide, Thiocarbamate insecticide Thiram 137-26-8 798O1 589 Fungicide Dithiocarbamate Thiram and NAD and IBA and 75497-92-6 S6O11 NA 463 Fungicide, Dithiocarbamate 2-methyl-1- Plant Growth naphthaleneacetamide and 2 Regulator methyl-1-naphthaleneacetic acid Tiocarbazil 36756-79-3 ##### NA911 Herbicide Thiocarbamate Triallate 23O3-17-5 78802 49 Herbicide Thiocarbamate US 2006/0276339 A1 Dec 7, 2006 50

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Tricopper dichloride 7O76-63-3 ##### NA 152 Microbiocide Dithiocarbamate, dimethyldithiocarbamate Inorganic-Copper Vernolate 1929-77-7 41.404 1987 Herbicide Thiocarbamate Zineb 12122-67-7 14506 627 Fungicide Dithiocarbamate, Inorganic-Zinc Zineb-ethylene thiuram NA. 1465 NA217 NA 216 Fungicide Dithiocarbamate, disulfide adduct Inorganic-Zinc Ziram 137-30-4 348OS 629 Fungicide, Dithiocarbamate, Microbiocide, Inorganic-Zinc Dog and Cat Repellent Ziram, cyclohexylamine 16SO9-79-8 34806 1328 Dog and Cat Dithiocarbamate, complex Repellent, Inorganic-Zinc Fungicide 1,3,5-Triethylhexahydro-s- 7779-27-3 82901 NA 823 Fungicide Triazine triazine 2-(Diethylamino)-4- 3004-70-4 8O812 NA 780 NA Triazine (isopropylamino)-6-methoxy-s- triazine 2-chloro-4- 29450-57-5 ##### NA135 NA Triazine ((hydroxymethyl)amino)-6- (isopropylamino)-s-triazine 3-(chloromethyl)-4-ketobenz 2431O-41-6 ##### NA. 162 Impurity Triazine 1,2,3-triazine (as impurity) 3-(Hydroxymethyl)-4- 2431O-40-5 ##### NA. 162 Impurity Triazine ketobenz-1,2,3-triazine (as impurity) Aatram (propachlor with 8070-76-6 8O816 NA 781. Herbicide Triazine, atrazine) (019101 + 080803) Chloroacetanilide Ametryne 834-12-8 80801 18 Herbicide Triazine Ametryne, other related NA 1071 NA. 160 90018. Herbicide Triazine Anilazine 101-05-3 8O811 256 Fungicide Triazine Atraton 1610-17-9 8O802 4OSO Herbicide Triazine Atrazine 1912-24-9 8O803 45 Herbicide Triazine Atrazine dealkylated NA 1059 NA. 157 4052 Breakdown Triazine broduct Atrazine, other related NA 1072 NA. 160 90045 Herbicide Triazine AZiprotryne 4658-28-0 ##### NA130 Herbicide Triazine Chlorazine 580-48-3 8O806 NA 777 NA Triazine Cyanatryn 21689-84-9 NA 230 NA229 Herbicide Triazine Cyanazine 21725-46-2 ##### 1640 Herbicide Triazine Cyanazine acid NA 1328 NA178 NA178 Breakdown Triazine broduct Cyanazine amide NA 1170 NA. 176 NA. 164 Breakdown Triazine broduct Cyanazine, other related NA 1133 NA166 91640 Herbicide Triazine Cyanuric acid 108-80-5 814O2 2138 Microbiocide, Triazine Water Treatment Cyanuric acid, monosodium 2624-17-1 NA 122 1031 Microbiocide, Triazine Salt Water Treatment Cybutryne 281.59-98-0 ##### 4033 Microbiocide Triazine Cyprazine 22936-86-3 ##### 1701 Herbicide Triazine Cyromazine 66215-27-8 ##### 2286 insecticide Triazine Deethyl ametryne NA1168 NA. 176 NA. 164 Breakdown Triazine broduct Deethyl hydroxyatrazine NA 1330 NA179 NA178 Breakdown Triazine broduct Deethyl-atrazine NA 1058 NA. 157 4051 Breakdown Triazine broduct Deethyl-simazine NA 1047 NA. 154 4096 Breakdown Triazine broduct Deethylhydroxysimazine NA 1064 NA. 159 5031 Breakdown Triazine broduct Deisopropyl atrazine NA1169 NA. 176 NA. 164 Breakdown Triazine broduct Deisopropyl hydroxyatrazine NA 1331 NA179 NA178 Breakdown Triazine broduct Deisopropyl prometryn NA 1334 NA179 NA179 Breakdown Triazine broduct US 2006/0276339 A1 Dec. 7, 2006 51

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Desamino-metribuzin NA. 1473 NA219 NA219 Breakdown Triazine product Desmetryne 101 4-69-3 80810 NA779 Herbicide Triazine Diaminochlorotriazine NA856 NA. 159 SO28 Breakdown Triazine product Diaminohydroxytriazine NA857 NA. 159 5032 Breakdown Triazine product Dichloro-s-triazinetrione 2782-57-2 204 Microbiocide, Triazine Water Treatment Dichloroisocyanuric acid, 2244-21-5 81403 Microbiocide, Triazine potassium salt Water Treatment Didealkyl atrazine NA 1329 NA178 NA178 Breakdown Triazine product Didealkyl hydroxyatrazine NA 1332 NA179 NA178 Breakdown Triazine product Diketo-desamino-metribuzin NA. 1475 NA219 NA219 Breakdown Triazine product Diketo-metribuzin NA. 1474 NA219 NA219 Breakdown Triazine product Dimethametryn 22936-75-0 8O815 2287 Herbicide Triazine Dipropetryn 41.47-51-7 ##### 2532 Herbicide Triazine Eglinazine 6616-80-4 NA2O7 NA2O7 Herbicide Triazine Eglinazine-ethyl 6616-80-4 NA218 NA217 Herbicide Triazine Ethiozin (ebuzinitycor) 64529-56-2 ##### NA15 NA Triazine Hexahydro-1,3,5-triethyl-S- 108-74-7 NA 12S 1670 Herbicide Triazine triazine Hexahydro-1,3,5-tris (2- 10282S1 83301 1171 Microbiocide Triazine hydroxyethyl)-s-triazine Hexahydro-1,3,5-tris(2- ##### 1915 NA Triazine hydroxypropyl)-s-triazine Hexahydro-1,3,5-tris(3- 751061 ##### NA 127 NA Triazine methoxypropyl)-1,3,5-triazine Hexazinone S1235-04-2 ##### 1871 Herbicide Triazine Hydroxyatrazine 2163-68-0 NA178 NA178 Breakdown Triazine product pazin 1912-25-O ##### NA 130 NA Triazine Somethiozin S7052-04-7 ##### NA875 NA Triazine Metamitron 41394-05-2 NA135 2672 Herbicide Triazine Methometon 1771-07-9 ##### NA 156 NA Triazine Methoprotryne 841-06-5 ##### NA. 154 Herbicide Triazine Metribuzin 21087-64-9 ##### 1692 Herbicide Triazine Metribuzin-DA NA 1053 NA 156 4079 Breakdown Triazine product Mono (trichloro) tetra 30622-37-8 856 Microbiocide, Triazine (monopotassium dichloro) Water penta-s-triazine Treatment MPMT 845-S2-3 827O1 2695 NA Triazine Potassium 1,3-dichloro-2,4,6- NA173 NA346 16SO NA Triazine trioxohexahydro-s-triazine Prefox (cyprazine with 8071-40-7 ##### NA 886 Herbicide Triazine ethiolate) Procyanazine 32889-48-8 ##### NA908 Herbicide Triazine Proglinazine 68228-20-6 NA. 209 NA. 209 Herbicide Triazine Proglinazine-ethyl 68228-18-2 NA218 NA218 Herbicide Triazine Prometon 1610-18-O 8O804 499 Herbicide Triazine Prometryn 7287-19-6 8O805 5O2 Herbicide Triazine Propazine 139-40-2 80808 SO4 Herbicide Triazine Pymetrozine 12331 2-89-O ##### 5232 Insecticide Triazine Sebuthylazine 7286-69-3 ##### NA 127 NA Triazine Secbumeton 26259-45-O ##### 2849 Herbicide Triazine Simazine 122-34-9 8O807 531 Herbicide Triazine Simetone 673-04-1 ##### 3532 Herbicide Triazine Simetryn 1014-7O-6 ##### 4097 NA Triazine Sodium dichloro-s- 2893-78-9 81.404 205 Microbiocide, Triazine triazinetrione Water Treatment Sodium dichloro-s- S1580-86-0 1818 Microbiocide, Triazine triazinetrione dihydrate Water Treatment US 2006/0276339 A1 Dec. 7, 2006 52

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Sym-triazine 108-80-5 814O2 893 Microbiocide, Triazine Water Treatment Terbumeton 33693-04-8 NA 190 NA 189 Herbicide Triazine Terbuthylazine 591 S-41-3 8O814 3004 Algaecide, Triazine Herbicide, Microbiocide Terbutryn 886-50-0 80813 1691 Herbicide Triazine Terbutryn, other related NA 1136 NA. 167 91.691 Herbicide Triazine Triaziflam 31475-57-5 NA 234 NA 233 Herbicide Triazine Trichloro melamine 21.07336 77101 1023 Microbiocide Triazine Trichloro-s-triazinetrione 87-90-1 81405 4O7 Microbiocide, Triazine Water Treatment Trietazine 912-26-1 8O809 NA 778 Herbicide Triazine 1,3-Diphenyl urea O2-07-8 NA 186 NA 18S Plant Growth Urea

3,4-Dichloromethylphenyl urea NA 1335 NA179 NA179 Urea

3,4-Dichlorophenyl urea S4536 NA179 NA179 Urea

3-(Trifluoromethyl)phenyl urea 3114-87-9 NA179 NA178 Urea

Amidosulfuron 20923-37-7 NA 183 NA 183 Sulfonylurea Anisuron 2689-43-2 ##### NA. 138 Benzoylle:8 AZimsulfuron 20162-55-2 ##### NA112 Sulfonylurea Bensulfuron 99283-01-9 NA 181 NA 18O Sulfonylurea Bensulfuron methyl 83OSS-99-6 ##### 2263 Sulfonylurea Bentaluron NA. 1405 NA 197 NA 197 Urea Benzthiazuron 929-88-0 ##### NA 133 Urea Buthiuron 3OO43-SS-1 NA 230 NA 230 Urea Buturon 3766-60-7 ##### NA 119 Urea Chlorbromuron 3360-45-7 90701 1733 Urea Chloreturon 2O782-58-5 NA. 231 NA 230 e r bi ci Phenylurea Chlorimuron 99283-OO-8 NA204 NA2O3 Sulfonylurea Chlorimuron ethyl 90982-32-4 ##### 2458 Sulfonylurea Chlorotoluron SS45-48-9 ##### NA 122 Urea Chloroxuron 982-47-4 255O1 576 Urea Chlorsulfuron 64902-72-3 ##### 2143 Sulfonylurea Cinosulfuron 94593-91-6 NA 183 NA 183 Sulfonylurea Cumyluron 99485-76-4 NA228 NA228 Urea Cyclosulfamuron 3.6849-15-S NA204 NA2O3 Sulfonylurea Cycluron 2163-69-1 35504 NA306 Urea Daimuron 42609-52-9 NA204 NA204 Phenylurea Demethylfluometuron NA 1333 NA179 NA178 Breakdo Will Urea broduct Dichloral urea 16-52-9 ##### NA 115 Herbici Urea Dilfenoxuron 4214-32-5 ##### NA 156 Herbici Urea Diflubenzuron 3.5367-38-5 ##### 1992 insectici Benzoy le:8 Dimefuron 342.05-21-5 NA 186 NA 18S Herbici Urea Diuron 33O-54-1 35.505 231 Herbici Urea EthametSulfuron 11353-84-5 NA 212 NA 212 Herbici Sulfony 8 EthametSulfuron-methyl 97780-06-8 ##### NA43 Herbici Sulfony 8 Ethidimuron 3OO43-49-3 ##### NA994 Herbici Urea Ethoxysulfuron 268O1-58-9 NA226 NA225 Herbici Sulfony 8 Fenuron O1-42-8 35507 4O72 Herbici Urea Fenuron trichloroacetate 4482-55-7 35508 5035 Herbici Urea Flazasulfuron O4040-78-0 NA 229 NA228 Herbici Sulfony 8 Flucycloxuron 13036-88-7 ##### NA109 Herbici Benzoy le:8 Flucycloxuron, (E) 94OSO-52-9 NA2O1 NA 200 Herbici Benzoy le:8 Fufenoxuron O1463-69-8 ##### NA901 insectici Benzoy le:8 Fluometuron 2164-17-2 35503 166 Herbici Urea Fluothiuron 33439-45-1 NA232 NA232 Herbici Phenylurea Flupyrsulfuron SO315-10-9 NA205 NA204 Herbici Sulfony 8 Flupyrsulfuron-methyl NA. 1460 NA 216 NA 216 Herbici Sulfony 8 Flupyrsulfuron-methyl, sodium 44740-54-5 NA218 NA217 Herbici Sulfony 8 Salt Forchlorfenuron 68157-60-8 ##### 5557 Plant Growth Urea Regulator Halosulfuron OO784-20-1 ##### 3919 Herbicide Sulfony 8 Hexaflumuron 86479-06-3 ##### 3899 insecticide Benzoy le:8 US 2006/0276339 A1 Dec. 7, 2006 53

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Chemical Class Imazosulfuron 122548-33-8 NA 229 NA 229 Sulfonylurea Iodosulfuron methyl 1851 19-76-0 NA 212 NA211 Sulfonylurea Iodosulfuron methyl, Sodium 1445SO-36-7 NA 212 NA211 Sulfonylurea Salt Isononuron 28805-78-9 ##### NA. 151 Urea Isoproturon 34123-59-6 ##### NA 155 Urea Isouron SS861-78-4 ##### NA 101 Urea Linuron 330-55-2 35506 361 Urea Lufenuron O3OSS-O7-8 NA 184 NA 183 e Benzoylurea Mesosulfuron-methyl 2O8465-21-8 ##### NA993 Sulfonylurea Methabenzthiazuron 8691-97-9 ##### NA 133 Urea Methiuron ##### NA. 145 Urea Methyldymron NA205 NA204 Phenylurea Metobenzuron 11578-32-6 ##### NA37 Urea Metobromuron 3060-89-7 35901 NA 313 Urea Metoxuron 9937-59-8 ##### NA135 Urea Metsulfuron NA 183 NA 182 Sulfonylurea Metsulfuron-methyl ##### 2222 Sulfonylurea Monisouron NA 233 NA232 Urea Monolinuron 746-81-2 ##### NA 119 Urea Monolinuron with paraquat 69312-6 7-0 ##### NA 119 Urea, Bipyridylium dichloride Monuron SO-68-5 355O1 408 ter Urea Monuron-TCA 40-41-0 355O2 409 ter Urea Neburon 555-37-3 12001 424 ter Urea Nicosulfuron 11991-09-4 ##### 3829 ter Sulfonylurea Norea 8530-56-8 35801 435 ter Urea Norea (stereochemistry NA2O1 NA 200 ter Urea unspecified) Norea, other related NA. 163 90435 Urea Novaluron 16714-46-6 NA226 NA226 Benzoy le:8 Oxasulfuron 44651-06-9 ##### NA991 Sulfony 8 Parafuron 71.59-99-1 35510 NA307 Urea Pencycuron 66063-05-6 ##### NA 103 Urea Penfluron 3.5367-31-8 ##### NA1OO Urea Phenobenzuron 449.583 ##### NA 133 Benzoy le:8 Primisulfuron-methyl 86209-51-0 ##### 5103 Sulfony 8 Prosulfuron 94.125-34-5 ##### 5115 Sulfony 8 Pyrazosulfuron 98.389-04-9 NA205 NA205 Sulfony 8 Pyrazosulfuron-ethyl 93697–74-6 NA218 NA217 Sulfony 8 Rimsulfuron 122931-48-O ##### 3835 Sulfony 8 Siduron 1982-49-6 35.509 603 Urea Sulfometuron 74223-56-6 NA206 NA205 Sulfony 8 Sulfometuron methyl 74222-97-2 ##### 2149 Sulfony 8 Sulfosulfuron 141776-32-1 856O1 S136 Sulfony 8 Tebuthiuron 34O14-18-1 ##### 1810 Urea Teflubenzuron 83121-18-0 ##### NA33 Benzoy Tetrafluoron 27954-37-6 ##### NA. 145 Phenylurea Thiazafluron 2S366-23-8 NA 190 NA 189 Urea Thidiazuron 51707-55-2 ##### 2162 Urea

Thifensulfuron 79.277-67-1 NA 183 NA 182 Sulfonylurea Thifensulfuron-methyl 79.277-27-3 ##### 2237 Sulfonylurea Triasulfuron 82097-SO-5 ##### S100 Sulfonylurea Tribenuron 106040-48-6 NA206 NA205 Sulfonylurea Tribenuron methyl 1012OO-48-O ##### 2338 Sulfonylurea Trifumuron 64628-44-0 ##### 2961 Benzoylurea TrifluSulfuron-methyl 126535-15-7 ##### 3875 Sulfonylurea Trimeturon 3OSO-27-9 ##### NA 121 Urea Tritosulfuron 1424.69-14-5 NA 234 NA 234 Sulfonylurea Bromacil 314-40-9 12301 83 Uracil Bromacil, dimethylamine Salt 69484-13-5 12304 840 Uracil Bromacil, lithium salt 53404-19-6 12302 1573 Uracil Bromacil, sodium salt 69484-12-4 12303 842 Uracil Butafenacil 134605-64-4 ##### NA992 Uracil Flupropacil 120890-70-2 NA 229 NA 229 Uracil Isocil 314-42-1 11801 NA 119 Uracil Lenacil 95177 ##### NA 155 Uracil Terbacil S902-51-2 12701 532 Uracil US 2006/0276339 A1 Dec. 7, 2006 54

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class 2-Hydroxy alachlor NA943 NA 183 26O2 Breakdown Chloroacetanilide product 3,4,5-tribromo salicylanilide, NA1122 NA. 16S 90833 Microbiocide Anilide other related 3,5-dibromosalicylanilide 2577-72-2 77405 12S6 Microbiocide Anilide 5,4-dibromosalicylanilide NA 1024 NA 122 1071 Microbiocide Anilide Aatram (propachlor with 8070-76-6 8O816 NA 781 Herbicide Triazine, atrazine) (019101 + 080803) Chloroacetanilide Acetochlor 34256-82-1 ##### 2349 Chloroacetanilide Alachlor 15972-60-8 90SO1 678 Chloroacetanilide Benodani 15310-01-7 ##### NA. 154 Anilide Butachlor 23184-66-9 ##### 40S6 Chloroacetanilide Butenachlor 873 10-56-3 NA206 NA2O6 Chloroacetanilide Clomeprop 84496-56-O NA204 NA2O3 Anilide Cyprofuram 69581-33-5 NA 186 NA 18S Anilide Cypromi 2759-71-9 26101 178 Anilide Delachlor 24353-58-O ##### NA132 Chloroacetanilide Diethatyl-ethyl 38727-55-8 ##### 1995 e r Chloroacetanilide Diflufenican 83164-33-4 NA 184 NA 183 Anilide Dimethachlor SOS 63-36-5 NA 184 NA 183 Chloroacetanilide Etobenzanid 79S40-50-4 NA 229 NA228 Anili Fenasulam 78.357-48-9 NA. 231 NA. 231 Anili Flufenace 1424,59-58-3 ##### 5293 Anili Flufenican NA 1568 NA 234 NA 234 Anili Flutolani 66332-96-5 ##### 2305 Anili Mefenace 732SO-68-7 NA 189 NA 188 Anili S378O-34-O ##### SO82 Anili

Mefluidide, diethanolamine salt S378O-36-2 ##### 1955 Anilide Mefluidide, potassium salt 836O1-83-6 ##### 5083 Anilide Mepronil 55814-41-0 NA 189 NA 188 Anilide Metazachlor 67129-08-2 NA 184 NA 183 Chloroacetanilide Metolachlor 51218-45-2 ##### 1996 Chloroacetanilide Metolachlor, (S) 87392-12-9 ##### 5133 Chloroacetanilide Monalide 7287-36-7 ##### NA134 Anili Naproanilide S2570-16-8 NA 233 NA232 Anili Ofurace 5881O-48-3 NA 189 NA 188 Anili Oxadixyl 77732-09-3 ##### 3539 Anili Perfluidone 37924-13-3 ##### 1895 Anili Perfluidone, diethanolamine NA991 NA. 671 1896 Anili Salt Pretilachlor 51218-49-6 NA 184 NA 184 Chloroacetanilide Propachlor 1918-16-7 19101 511 Chloroacetanilide Propanil 709-98-8 282O1 503 Anilide Propisochlor 86,763-47-5 NA 233 NA 233 Chloroacetanilide Prynachlor 21267-72-1 ##### NA. 138 Chloroacetanilide Regulator Pyracarbolid 24691-76-7 NA 210 NA. 209 Fungicide Anilide Salicylanilide 87-17-2 774O7 450 Fungicide, Anilide Microbiocide Sodium salicylanilide 2S1930 ##### NA. 145 Fungicide Anilide Thenylchlor 96491-05-3 NA 229 NA 229 Herbicide Chloroacetanilide Triclocarban 101-20-2 27901 844 NA Anilide 1,2,4-triazole 288-88-0 NA968 3560 NA Azole 1H-benzo triazole 95-14-7 NA493 2418 NA Azole 2,2'-Dithiobisbenzothiazole 120-78-5 92O2 NA109 Fungicide, Mercaptobenzothiazole Microbiocide, insecticide 2-(2'-hydroxy-5-methyl 2440-22-4 NA 103 26O7 Fungicide Azole phenyl)-benzotriazole 2-(dithiocyanomethylthio)- NA. 1346 NA 192 NA 191 Fungicide Mercaptobenzothiazole benzothiazole 2 7991O-32-0 ##### NA925 Microbiocide Mercaptobenzothiazole (thiocyanomethylthio)benzothiazole with 2'-hydroxyethyl-2,3- dibromopropionate 2-EEEBC 62732-91-6 ##### 1983 Fungicide Benzimidazole 2-Mercaptobenzothiazole 149-30-4 51701 556 Fungicide, Mercaptobenzothiazole Microbiocide US 2006/0276339 A1 Dec. 7, 2006 55

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class 2-Mercaptobenzothiazole, 1 5468-43-9 51702 NA 423 Fungicide, Mercaptobenzothiazo (hydroxyethyl)pyridinium salt Microbiocide 2-Mercaptobenzothiazole, S3404-53-8 51708 NA 426 Fungicide, Mercaptobenzothiazo ferric salt Microbiocide 2-Mercaptobenzothiazole, S3404-58-3 NA 108 Fungicide, Mercaptobenzothiazo manganese salt Microbiocide, insecticide 2-Mercaptobenzothiazole, S902-85-2 51706 NA 424 Fungicide, Mercaptobenzothiazo monoethanolammonium salt Microbiocide 2-Mercaptobenzothiazole, 7778-70-3 51707 NA 425 Fungicide, Mercaptobenzothiazo potassium salt Microbiocide 2-Mercaptobenzothiazole, 2492-26-4 S1704 3.064 Microbiocide, Mercaptobenzothiazo Sodium salt Fungicide 2-Mercaptobenzothiazole, 2492-26-4 S1704 613 Fungicide, Mercaptobenzothiazo Sodium salt Microbiocide 2-Mercaptobenzothiazole, zinc 155-04-4 51705 1449 Fungicide, Mercaptobenzothiazo Salt Microbiocide Inorganic-Zinc 5-Chloro-2- S331-91-9 NA 200 NA 199 NA Mercaptobenzothiazo mercaptobenzothiazole 5-Chloro-2- 51703 1238 Microbiocide Mercaptobenzothiazo mercaptobenzothiazole, lauryl pyridinium salt 5-Chloro-2- NA 421 1597 Microbiocide, Mercaptobenzothiazo mercaptobenzothiazole, lauryl Fungicide pyridinium salt 5-Chloro-2- 53404-93-6 51709 NA 427 Microbiocide, Mercaptobenzothiazo mercaptobenzothiazole, Zinc Fungicide Inorganic-Zinc Salt AZaconazole 6O207-31-0 ##### NA 105 insecticide, Azole Fungici Benomyl 7804-3S-2 991O1 1552 Fungici Benzimidazole Bitertanol SS179-31-2 ##### NA959 Fungici Azole Bromuconazole 16255-48-2 ##### NA 8 Fungici Azole Carbendazim O605-21-7 ##### 2176 Fungici Benzimidazole Carbendazim hydrochloride ##### NA 121 Fungici Benzimidazole Carbendazim phosphate 991O2 1974 Fungici Benzimidazole CGA-64251 6O2O7-93-4 ##### 2452 Fungici Azole Chlorfeinapyr 224.53-73-0 ##### 3938 insecticide Pyrazole Chlorfurazole 3615-21-2 ##### NA. 139 NA Benzimidazole Cyazofamid 20116-88-3 NA 216 NA215 Fungicide Azole Cypendazole ##### NA 156 NA Benzimidazole Cyproconazole ##### 5105 Fungici Azole Dilfenoconazole 19446-68-3 ##### SO24 Fungici AZO Diniconazole 83657-18-5 ##### 2SOO Fungici AZO Diniconazole (stereochemistry 83657-24-3 NA 200 NA 200 Fungici AZO unspecified) Fenapanil 61019-78-1 ##### 2083 Fungici AZO Fenbuconazole 14369-43-6 ##### 3905 Fungici AZO Fluotrimazole 31251-03-3 NA2O7 NA2O7 Fungici AZO Fluguinconazole 36426-54-5 NA 184 NA 183 Fungici AZO Fusilazole 85SO9-19-9 ##### 2278 Fungici AZO Flutriafol ##### NA 107 Fungici Azole Fuberidazole ##### NA1SO Fungici Benzimidazole Furconazole 12839-33-5 NA 196 NA 196 Fungici Azole Furconazole-cis 12839-32-4 NA. 208 NA2O7 Fungici AZO Hexaconazole ##### NA 23 Fungici AZO mazalil ##### 2O84 Fungici AZO mazalil Sulfate ##### NA921 Fungici AZO mibenconazole 86598-92-7 NA205 NA204 Fungici AZO Soxachlortole 41112-06-3 NA232 NA232 Herbici Cyclopropylisoxazole Metconazole 25116-23-6 ##### NA 101 Fungicide Azole Metronidazole 443-48-1 ##### 2208 Microbiocide Azole Myclobutanil 88671-89-0 ##### 2.245 Fungicide Azole Naphthyl triazole stilbene NA 742 NA135 2698 NA Azole monosulfonate Paclobutrazol 76738-62-0 ##### 2259 Plant Growth Azole Regulator Penconazole 66246-88-6 ##### NA109 Fungicide Azole Prochloraz 67747-09-5 ##### NA29 Fungicide Azole Prochloraz - manganese 75747-77-2 ##### NA 104 Fungicide Azole complex (4:1) US 2006/0276339 A1 Dec. 7, 2006 56

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Prochloraz Zinc complex NA 1555 NA226 NA226 Fungicide Azole Propiconazole 6O2O7-90-1 ##### 2276 Fungicide Azole Pyrazoxyfen 71561-11-0 NA 189 NA 189 Herbicide Pyrazole R 23979 imazalil base NA 451 NA 809 284.4 Fungicide Azole TCMTB 21564-17-0 35603 971 Microbiocide, Mercaptobenzothiazole Fungicide Tebuconazole 107534-96-3 ##### 3850 Fungicide Azole Tebufenpyrad 119168-77-3 90102 NA 845 insecticide Pyrazole Terrazole 2593-15-9 84701 S8O Fungici Azole Tetraconazole 112281-77-3 ##### NA979 Fungici Azole Thiabendazole 148-79-8 6O101 587 Fungici Benzimidazole Thiabendazole, hypophosphite 28SS8-32-9 6O102 1952 Fungici Benzimidazole Salt Thiophanate 235 64-06-9 ##### 1684 Fungici e Benzimidazole Thiophanate-methyl 23S64-OS-8 ##### 1696 Fungicide Benzimidazole precursor Tolyl triazole 29395-43-1 NA962 2950 NA Azole Triadimefon 43121-43-3 ##### 2133 Fungicide Azole Triadimenol SS219-65-3 ##### 2307 Fungicide, Azole Breakdown product Triazbutil 16227-10-4 ##### NA931 Fungici Azole Tricyclazole 41814-78-2 ##### SOO2 Fungici Azole Trifumizole 68694-11-1 ##### 2260 Fungici Azole Trifumizole 99387-89-0 NA2O1 NA2O1 Fungici Azole Triticonazole 131983-72-7 ##### NA 101 Fungici Azole Uniconazole 83657-22-1 ##### NA38 Plant Growth Azole Regulato 2-EEEBC 62732-91-6 ##### 1983 Fungici Benzimidazole Benomyl 17804-3S-2 991O1 1552 Fungici Benzimidazole Carbendazim 10605-21-7 ##### 2176 Fungici Benzimidazole Carbendazim hydrochloride 37S74-18-8 ##### NA 121 Fungici Benzimidazole Carbendazim phosphate S2316-SS-9 991O2 1974 Fungici Benzimidazole Chlorfurazole 3615-21-2 ##### NA. 139 NA Benzimidazole Cypendazole 28S59-00-4 ##### NA 156 NA Benzimidazole Fuberidazole 3878-19-1 ##### NA1SO Fungicide Benzimidazole Thiabendazole 148-79-8 6O101 587 Fungicide Benzimidazole Thiabendazole, hypophosphite 28SS8-32-9 6O102 1952 Fungicide Benzimidazole Salt Thiophanate 235 64-06-9 ##### 1684 Fungicide Benzimidazole Thiophanate-methyl 23S64-OS-8 ##### 1696 Fungicide Benzimidazole precursor 1-(3- S1971-67-6 ##### NA110 NA Carboxamide chlorophthalimido)cyclohexane carboxamide Carboxin 5234-68-4 902O1 1755 Fungicide Carboxamide Cisanilide 34484-77-0 ##### NA 144 Herbicide Carboxamide Cyclafuramide 34849-42-8 ##### NA132 Fungicide Carboxamide Fenfuram 24691-8O-3 NA 188 NA 187 Fungicide Carboxamide Furmecyclox (Xyligen B) 60S68-05-0 ##### NA18 Fungicide Carboxamide Methfuroxam 28730-17-8 ##### NA949 Fungicide Carboxamide Metsulfowax 21452-18-6 NA 189 NA 188 Fungicide Carboxamide Nitrofurazone (not subject to 59-87-O ##### NA128 NA Carboxamide FIFRA: 8709-e pm 24) Oxycarboxin S259-88-1 902O2 1434 Fungicide Carboxamide p-Benzoquinone 61566-21-0 ##### NA 133 NA Carboxamide semicarbazone Chlozolinate 72391-46-9 NA 183 NA 182 Fungicide Dicarboximide Iprodione 36734-19-7 ##### 2081 Fungicide Dicarboximide Myclozolin 54864-61-8 NA. 209 NA2O8 Fungicide Dicarboximide N-(2-Ethylhexyl)-1-isopropyl 13358-11-7 ##### NA 121 Synergist Dicarboximide 4-methyl-4-cyclohexene-1,2- dicarboximide N-octyl bicycloheptene 113-48-4 57001 396 Synergist Dicarboximide dicarboximide Vinclozolin 50471-44-8 ##### 2129 Fungicide Dicarboximide Calcium S895-18-1 145O1 NA. 139 Microbiocide Dithiocarbamate ethylenebis(dithiocarbamate) Cufraneb 11096-18-7 NA 181 NA 18O Fungicide Dithiocarbamate Diammonium 6O7313 145O2 NA 140 Microbiocide Dithiocarbamate ethylenebis(dithiocarbamate) US 2006/0276339 A1 Dec 7, 2006 57

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Ferbam 14484-64-1 348O1 288 Fungicide Dithiocarbamate Ferric nitroso dimethyl 83542-83-0 ##### NA149 Microbiocide Dithiocarbamate dithiocarbamate Mancopper S3988-93-5 NA 181 NA 180 Fungicide Dithiocarbamate Mancozeb 22331 OO 14504 211 Fungicide Dithiocarbamate, Inorganic-Zinc Maneb 12427-38-2 145OS 369 Fungicide Dithiocarbamate Maneb and nickel sulfate 8OOS-46-7 ##### NA 158 Fungicide Dithiocarbamate, hexahydrate (014505 + 050505) Inorganic-Nickel Manganous 15339-36-3 348O2 NA 304 Fungicide Dithiocarbamate dimethyldithiocarbamate Mercuric dimethyl 15415-64-2 348O8 709 Microbiocide Inorganic-Mercury, dithiocarbamate Heavy metal, Dithiocarbamate Metam sodium, dihydrate 137-42-8 39003 NA163 Fumigant, Dithiocarbamate Fungicide, Microbiocide, Algaecide, Nematicide Metam-sodium 6734-80-1 39003 616 Fumigant, Dithiocarbamate Herbicide, Fungicide, Microbiocide, Algaecide, Nematicide Metiram 90O6-42-2 146O1 493 Fungicide Dithiocarbamate, norganic-Zinc Morpholinomethyl 31848-11-0 ##### NA 158 Microbiocide Dithiocarbamate dimethyldithiocarbamate Nabam 142-59-6 14503 417 Fungicide, Dithiocarbamate Herbicide Phenylmercuric 324O7-99-1 66008 NA555 Microbiocide, Organomercury, dimethyldithiocarbamate Fungicide Dithiocarbamate, Heavy metal Potassium ammonium 22221-14-3 14507 NA 141 Microbiocide Dithiocarbamate ethylenebis(dithiocarbamate) Potassium dimethyl dithiocarbamate 128-03-0 348O3 1934 Microbiocide Dithiocarbamate Potassium N-hydroxymethyl 51026-28-9 ##### 1824 NFA Dithiocarbamate N-methyldithio carbamate Potassium N-methyldithio 137-41-7 39002 970 Fumigant, Dithiocarbamate carbamate Fungicide, Microbiocide, Algaecide, Nematicide Propineb 12071-83-9 ##### NA 155 Fungicide, Dithiocarbamate, Microbiocide norganic-Zinc Sodium dimethyl dithio 128-04-1 34804 S48 Fungicide Dithiocarbamate carbamate Sulfallate 95-06-7 39001 115 Herbicide Dithiocarbamate Tert-butyl dimethyl trithio 3304-97-0 34807 1383 Rodent Dithiocarbamate peroxycarbamate Repellent Tert NA 1130 NA166 91383 NA Dithiocarbamate butyldimethyltrithioperoxycarbamate, other related Thiram 137-26-8 798O1 589 Fungicide Dithiocarbamate Thiram and NAD and IBA and 75497-92-6 S6O11 NA 463 Fungicide, Dithiocarbamate 2-methyl-1- Plant Growth naphthaleneacetamide and 2 Regulator methyl-1-naphthaleneacetic acid Tricopper dichloride 7O76-63-3 ##### NA 152 Microbiocide Dithiocarbamate, dimethyldithiocarbamate Inorganic-Copper Zineb 12122-67-7 14506 627 Fungicide Dithiocarbamate, Inorganic-Zinc Zineb-ethylene thiuram NA. 1465 NA217 NA 216 Fungicide Dithiocarbamate, disulfide adduct Inorganic-Zinc Ziram 137-30-4 348OS 629 Fungicide, Dithiocarbamate, Microbiocide, Inorganic-Zinc Dog and Cat Repellent US 2006/0276339 A1 Dec. 7, 2006 58

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Zirm, cyclohexylamine 34806 1328 Dog and Cat Dithiocarbamate, complex Repellent, Inorganic-Zinc Fungicide 2,2'-Dithiobisbenzothiazole 120-78-5 NA109 Fungicide, Mercaptobenzothiazo Microbiocide, Insecticide 2-(dithiocyanomethylthio)- NA. 1346 NA 192 NA 191 Fungicide Mercaptobenzothiazo benzothiazole 2 7991O-32-0 ##### NA925 Microbiocide Mercaptobenzothiazo (thiocyanomethylthio)benzothiazole with 2'-hydroxyethyl-2,3- dibromopropionate 2-Mercaptobenzothiazo e 149-30-4 51701 556 Fungicide, Mercaptobenzothiazo Microbiocide 2-Mercaptobenzothiazo e, 1 5468-43-9 51702 NA 423 Fungicide, Mercaptobenzothiazo (hydroxyethyl)pyridinium salt Microbiocide 2-Mercaptobenzothiazo S3404-53-8 51708 NA 426 Fungicide, Mercaptobenzothiazo ferric salt Microbiocide 2-Mercaptobenzothiazo S3404-58-3 NA 108 Fungicide, Mercaptobenzothiazo manganese salt Microbiocide, insecticide 2-Mercaptobenzothiazo S902-85-2 51706 NA 424 Fungicide, Mercaptobenzothiazo monoethanolammonium salt Microbiocide 2-Mercaptobenzothiazo 7778-70-3 51707 NA 425 Fungicide, Mercaptobenzothiazo potassium salt Microbiocide 2-Mercaptobenzothiazo 2492-26-4 S1704 3.064 Microbiocide, Mercaptobenzothiazo Sodium salt Fungicide 2-Mercaptobenzothiazo 2492-26-4 S1704 613 Fungicide, Mercaptobenzothiazo Sodium salt Microbiocide 2-Mercaptobenzothiazo 155-04-4 51705 1449 Fungicide, Mercaptobenzothiazo Salt Microbiocide Inorganic-Zinc 5-Chloro-2- S331-91-9 NA 200 NA 199 NA Mercaptobenzothiazo mercaptobenzothiazole 5-Chloro-2- 51703 1238 Microbiocide Mercaptobenzothiazo mercaptobenzothiazole, lauryl pyridinium salt 5-Chloro-2- NA 421 1597 Microbiocide, Mercaptobenzothiazo mercaptobenzothiazole, lauryl Fungicide pyridinium salt 5-Chloro-2- 53404-93-6 51709 NA 427 Microbiocide, Mercaptobenzothiazo mercaptobenzothiazole, Zinc Fungicide norganic-Zinc Salt TCMTB 21564-17-0 35603 971 Microbiocide, Mercaptobenzothiazo Fungicide Ancymidol 12771-68-5 ##### 1744 Plant Growth Pyrimidine Regulato Bupirimate 41483-43-6 ##### 2430 Fungici Pyrimidine CloranSulam 159518-97-5 NA. 231 NA. 231 Herbici Triazolopyrimidine Cloransulam-methyl 1471SO-35-4 ##### NA112 Herbici Triazolopyrimidine Dimethirimol S221-53-4 ##### NA128 Fungici Pyrimidine Ethirimol 23947-6O-6 ##### NA 129 Fungici Pyrimidine Fenarimol 6O168-88-9 ##### 1980 Fungici Pyrimidine Ferimzone 89269-64-7 NA2O3 NA2O2 Fungici Pyrimidine Flurprimidol S642S-91-3 ##### 2320 Plant Growth Pyrimidine Regulato Nuarimol 63284-71-9 ##### NA 126 Fungici Pyrimidine Pyrimethanil 53112-28-0 ##### NA30 Fungici Pyrimidine Azoxystrobin 131860-33-8 ##### 4037 Fungici Strobin Dimoxystrobin 149961-52-4 NA211 NA 210 Fungici Strobin Kresoxim-methyl 143390-89-O ##### S4S1 Fungici Strobin Metominostrobin 133408-SO-1 NA211 NA 210 Fungici Strobin Picoxystrobin 117428-22-5 NA211 NA 210 Fungici Strobin Pyraclostrobin 17SO13-18-0 NA211 NA 210 Fungici Strobin Trifloxystrobin 141517-21-7 ##### 5321 Fungici Strobin chloroneb 2675-77-6 273O1 135 Fungici Substituted Benzene Chlorothalonil 1897-45-6 81901 677 Fungici Substituted Benzene Dichlobenil 1194-65-6 274O1 112 Herbici Substituted benzene Dichloran 99-30-9 31301 81 Fungici Substituted Benzene PCNB 82-68-8 565O2 464 Fungici Substituted Benzene Nematic e Algaeci US 2006/0276339 A1 Dec. 7, 2006 59

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class PCNB, other related NA11OO NA. 163 90464 Fungici Substituted Benzene Algaeci Nematiciid e Captafo 190444 81702 NA 787 Fungici Thiophthalimide Captafol (cis isomer) 2939-80-2 81701 292 Fungici Thiophthalimide Capt8 133-06-2 81301 104 Fungici Thiophthalimide Captan, other related NA 1074 NA. 161 90.104 Fungici Thiophthalimide Folpet 133-07-3 816O1 294 Fungici Thiophthalimide Merpafolcis isomer 190444 81701 NA. 163 Fungici Thiophthalimide Benalaxy 71626-11-4 ##### NA 102 Fungici Xylylalanine Furalaxyl S7646-30-7 NA 188 NA 188 Fungici Xylylalanine L-Metalaxyl 69516-34-3 ##### NA929 Fungici Xylylalanine Mefenoxam 70630-17-0 ##### 4011 Fungici Xylylalanine Mefenoxam, other related NA 1152 NA168 94O11 Fungici Xylylalanine Metalaxy S7837-19-1 ##### 2132 Fungici Xylylalanine Metalaxyl-M 70630-17-0 NA219 NA218 Fungicide Xylylalanine lkyl amino)-3- 61791-67-1 67311 NAS86 Microbiocide Alkyl Amino Propane aminopropane *(47% C12, C14, 10% C18, 9% C10, 8% C16, 8% C8) lkyl amino)-3- 61791-63-7 673O1 NAS83 Microbiocide Alkyl Amino Propane aminopropane (as in fatty acids of coconut oil) lkyl amino)-3- 68911-78-4 67306 NAS85 Microbiocide Alkyl Amino Propane aminopropane diacetate *(37% C18, 29% C16, 23% C18, 3% C16', 3% C14, .5% C18", 1% C14, 1% C12, 0.5% C15) -(Alkyl amino)-3- NA 1191. 67313 NA. 167 Microbiocide Alkyl Amino Propane aminopropane diacetate (as in acids of coconut oil) kyl amino)-3- NA 1192. 67319 NA. 167 Microbiocide, Alkyl Amino Propane annoprobane monoacetate Algaecide *(47% C12, 18% C14, 10% C18, 9% C10, 8% C16, 8% C8) kyl amino)-3- NA 1193 673O4 NA. 167 Microbiocide Alkyl Amino Propane aminopropane propionate er acetate complex kyl-amino)-3- NA1494 NA221 NA221 Microbiocide Alkyl Amino Propane aminopropane hydrochloride kylamino)-3- 681.SS-37-3 67310 1830 Microbiocide Alkyl Amino Propane

kylamino)-3- NA. 1495 NA221 NA221 Microbiocide Alkyl Amino Propane carboxymethylaminopropane kyl (C6 to C18) amino-3- NA994 NA721 2365 Microbiocide Alkyl Amino Propane annoprobane acetate (C6-C18) amino-3- 61791-64-8 673O2 954 Microbiocide Alkyl Amino Propane aminopropane diacetate -alkylamino-2-aminopropane 61791-64-8 673O2 335 Microbiocide Alkyl Amino Propane monoacetate, alkyl erived Ol coconut oil fatty acids -Alkylamino-3-aminopropane 681.SS-43-1 6.7309 972 Microbiocide, Alkyl Amino Propane hydroxyacetate, alkyl derived Soap/Surfactant Ol coconut oil fatty acids Alkyl (53% C12, 19% C14, 61791-58-O 67305 78O Microbiocide Alkyl Amino Propane 8.5% C16, 7% C8, 6.5% C10, 6% C18)-1,3-propane diamine Alkyl-1,3-propylene diamine 61790-63-7 NASS8 380 Microbiocide, Alkyl Amino Propane acetate, alkyl derived from Soap/Surfactant coconut oil fatty acids Alkyl-1,3-propylene diamine 68155-42-O ##### 841 Microbiocide, Alkyl Amino Propane adipate, alkyl erived from Soap/Surfactant coconut oil fatty acids Alkyl-1,3-propylene diamine, NA287 NAS59 379 Microbiocide, Alkyl Amino Propane alkyl derived rom coconut oil Soap/Surfactant fatty acids N-(2 -cyanoethyl NA 187 67321 957 Adjuvant Alkyl Amino Propane 1,3-diamino propane US 2006/0276339 A1 Dec. 7, 2006 60

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class N-Alkyl-1,3-propylene diamine 681.88-29-4 67307 1735 Microbiocide, kyl Amino Propane monobenzoate, alkyl derived Soap/Surfactant from coconut oil fatty acids Tall oil fatty acid soap of N 61790-55-4 NA924 3463 Microbiocide, kyl Amino Propane alkyl (C16-C18) propyl Insecticide diamine 2,2'-Methylenebis(4,6- 1940-43-8 SSOO4 NA455 Microbiocide hlorina Pheno dichlorophenol) 2,2'-Thiobis(4,6- 97-18-7 NAS39 NA hlorina Pheno dichlorophenol) 2.2.2-Trichloro-N- 3583-63-9 ##### NA. 151 NA hlorina Pheno (pentachlorophenyl)acetimidoyl chloride 2.2-methylene bis(4,6- 68957-70-0 55006 1843 Microbiocide hlorina Pheno dichlorophenol), sodium salt 2,3,4,6-tetrachlorophenol, 53535-27-6 63.007 1725 Wood hlorinated pheno potassium salt Preservative, Fungicide 2,4,5-trichloropheno 95-95-4 64210 1382 Micro bioci hlorinated pheno Algaecide 2,4,5-Trichlorophenol salt of 53404-83-4 64211 NAS42 NA hlorina Pheno 2,6- bis(dimethylamino)methyl)cyclohexanone 2,4,5-trichlorophenol, 3S471-43-3 64204 1 OSO Micro bioci hlorinated pheno potassium salt 2,4,5-trichloropheno NA1128 NA166 91OSO Micro bioci hlorinated pheno potassium salt, other related 2,4,5-trichlorophenol, sodium 136-32-3 64217 1656 Micro bioci hlorinated pheno sal 2,4,5-Trichlorophenol, sodium 3784-03-0 64220 NAS45 Micro bioci hlorina Pheno sal Algaecide 2,4,6-trichloropheno 88-06-2 64212 640 Micro bioci hlorinated pheno 2,4-dichlorophenol 120-83-2 NA 105 2499 NA hlorinated pheno 2-(trichlorophenoxy)ethyl 69633-04-1 ##### NA. 152 Herbicide hlorina Pheno rogen Sulfate 2-chloro-4-phenylphenol 92-04-6 846 Micro bioci hlorina Pheno 2-chloro-4-phenylphenol, 18128-16-0 1061 Micro bioci hlorina Pheno potassium salt 2-chloro-4-phenylphenol, 31366-97-9 62215 1632 Micro bioci hlorina Pheno Sodium salt 2-Chlorophenol 95-57-8 62.204 NASO4 Micro bioci hlorina Pheno 3-chloro-2-biphenylol, sodium 10605-11-5 62213 NASOS Micro bioci hlorina Pheno Salt 4 & 6-chloro-2-phenylphenol NA964 NA 419 1566 Micro bioci hlorina Pheno 4 & 6-chloro-2-phenylphenol, NA965 NA 420 1604 Micro bioci hlorina Pheno potassium salts, mixed 4 & 6-chloro-2-phenylphenol, NA963 NA 413 1594 Micro bioci hlorina Pheno Sodium salts, mixed 4 & 6-chloro-2-phenylphenol, NA 1132 NA166 Micro bioci hlorinated pheno other related 4 or 6-chloro-2-phenylphenol 53537-62-5 62216 NASO7 Micro bioci hlorina Pheno 4 or 6-chloro-2-phenylphenol, S3537-63-6 62214 NASO6 Micro bioci hlorina Pheno diethanolamine salt 4,6-dichloro-2-phenylphenol 5335-24-O 64216 1062 Micro biocide hlorinated pheno 4,6-dichloro-2-phenylphenol, 53404-30-1 64215 1059 Micro biocide hlorinated pheno potassium salt 4-chloro-2-cyclopentyl phenol, 64214 1237 Micro bioci hlorinated pheno potassium salt Fungicide 4-chloro-2-cyclopentylphenol 13347-42-7 836 Micro bioci hlorinated pheno Fungicide 4-chloro-2-phenylphenol 607-12-5 62208 945 Micro biocide hlorinated Pheno 4-chloro-2-phenylphenol, 53404-21-0 62.209 947 Micro biocide hlorinated Pheno potassium salt 4-chloro-2-phenylphenol, 10605-10-4 62212 946 Micro bioci hlorina Pheno Sodium salt 4-chloro-cyclopentylphenol, 53404-20-9 64218 1395 Micro bioci hlorinated pheno Sodium salt Fungicide 6-chloro-2-phenylphenol 85-97-2 62210 948 Micro biocide hlorinated Pheno 6-chloro-2-phenylphenol, 18128-17-1 62211 950 Micro biocide hlorinated Pheno potassium salt US 2006/0276339 A1 Dec. 7, 2006 61

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class 6-chloro-2-phenylphenol, 63992-41-6 NA 414 949 NA Chlorinated phenol Sodium salt 6-chlorothymol 89-68-9 80403 NA 775 NA Chlorinated Phenol 6-tert-Butyl-4-chloro-m-cresol 3O894-16-7 ##### NA 127 Microbiocide Chlorinated Phenol Chlorbisan 4418-66-0 642O8 127 Microbiocide Chlorinated Phenol Chloroxylenol 88-04-0 868O1 925 Microbiocide Chlorinated phenol Copper pentachlorophenate 15773-35-0 63.01.1 NAS12 Wood Chlorinated Phenol, Preservative, Inorganic-Copper Microbiocide, Algaecide, Fungicide Dehydroabietylamine NA72 Wood Chlorinated Phenol pentachlorophenate Preservative, Microbiocide, Algaecide, Fungicide Dichlorophene 97-23-4 55001 Herbicid Chlorinated Pheno Fungicide, Microbiocide Disodium 2,2'- 3247-34-5 44903 NA380 NA C l orinated Pheno methylenebis(3,4,6- Erichlorophenate) Ethylmercury 22232-28-6 41504 NA359 Microbiocide Organomercury, pentachlorophenate Chlorinated Phenol, Heavy metal Fenticlor 97-24-5 64209 NA541 Microbiocide Chlorinated Pheno Hexachlorophene 70-30-4 44901 322 Microbiocide, Chlorinated Pheno Fungicide Hexachlorophene, sodium salt S736-15-2 44902 413 Microbiocide Chlorinated Pheno Ortho-benzyl-para 120-32-1 622O1 522 Microbiocide, Chlorinated pheno chlorophenol Fungicide Ortho-benzyl-para 3S471-49-9 622O2 936 Microbiocide Chlorinated pheno chlorophenol, potassium salt Ortho-benzyl-para 31.84-65-4 622O3 937 Microbiocide, Chlorinated pheno chlorophenol, Sodium salt Fungicide Para-chloro-meta-cresol 59-50-7 642O6 1813 Microbiocide, Chlorinated Pheno Fungicide para-Chloro-ortho-cresol 1570-64-5 621.90 NASO3 NA Chlorinated Pheno Para-chlorophenol 106–48-9 NA 124 1572 NA Chlorinated pheno PCP 87-86-5 63001 465 Wood Chlorinated Pheno Preservative, Microbiocide, Algaecide, Fungicide, Mollusci cide, Herbicid e PCP, other related NA1101 NA. 163 9046S Wood Chlorinated Phenol Preserva ive, Microbiocide, Algaeci Fungicide, Mollusci PCP, potassium salt 7978-73-6 1049 Wood Chlorinated Phenol Preserva ive, Microbiocide, Algaeci Fungicide, Mollusci PCP, sodium salt 131-52-2 63003 Wood Chlorinated Phenol Preserva ive, Microbiocide, Algaeci Fungici Mollusci PCP, sodium salt, other related NA 1110 NA. 164 90540 Wood Chlorinated Phenol Preservative, Microbiocide, Algaecide, Fungicide, Molluscicide US 2006/0276339 A1 Dec 7, 2006 62

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Pentachlorophenol, Zinc salt 2917-32-O 63008 NAS10 Wood Chlorinated Phenol, Preservative, Inorganic-Zinc Microbiocide, Algaecide, Fungicide Pentachlorophenyl laurate 3772-94-9 63010 NAS11 Wood Chlorinated Phenol Preservative, Microbiocide, Algaecide, Fungicide Potassium 2,2'- 67923-62-0 44904 NA381 Microbiocide Chlorinated Pheno methylenebis(3,4,6- trichlorophenate) Potassium 2.4.6- 2591-21-1 642.19 NA544 Microbiocide Chlorinated Pheno trichlorophenate Potassium ortho-cyclopentyl 64214 1542 Microbiocide, Chlorinated pheno para-chlorophenate Fungicide Sodium 2,2'-methylenebis(4- 10254-48-5 55005 NA 456 insecticide, Chlorinated Pheno chlorophenate) Fungicide, Microbiocide Sodium chlorophenates 773 NA Chlorinated Pheno Sodium dichlorophenate NA. 1399 NA 197 NA 196 Fungicide, Chlorinated Pheno Microbiocide Sodium p-chloro-m-cresolate 15733-22-9 642OS NAS40 Microbiocide Chlorinated Pheno (80IOOleO 25167-83-3 63004 777 Woo Chlorinated pheno Preservative, Fungicide etrachlorophenol, alkylamine NA 1007 NA938 1401 Woo Chlorinated pheno Preservative, Fungicide Tetrachlorophenol, coconut NA 1008 NA939 Woo Chlorinated pheno amine Salt Preservative, Fungicide etrachlorophenol, other NA 1118 NA. 16S 90777 Woo Chlorinated pheno Preservative, Fungicide etrachlorophenol, potassium 53535-27-6 63.007 1753 Woo Chlorinated pheno Preservative, Fungicide etrachlorophenol, Sodium salt 25567-55-9 6300S 776 Woo Chlorinated pheno Preservative, Fungicide Tetrachlorophenol, Sodium salt, NA 1117 NA. 16S 90776 Woo Chlorinated pheno other related Preservative, Fungicide Tetrachlorophenols, alkyl 137543-70-5 63006 NASO9 Woo Chlorinated Pheno amine salt * (as in fatty acids of Preservative, coconut oil) Fungicide Trichlorophenol 95-95-4 64210 11.89 Microbiocide, Chlorinated pheno Algaecide Trichlorophenol, Sodium salt 136-32-3 64217 96.O Microbiocide, Chlorinated pheno Algaecide Trichlorophenol, Sodium salt, NA1127 NA166 90960 Microbiocide C l O ri l 8. e (O other related Triclosan 3380-34-5 S4901 1371 Microbiocide Chlorinated Pheno Vancide 30-R 6385-58-6 642O3 612 Microbiocide Chlorinated Pheno Zinc 2,4,5-trichlorophenate 136-24-3 64221 NAS46 NA Chlorinated Phenol, Inorganic-Zinc Zinc trichlorophenate 3.0143-22-7 64213 NAS43 Chlorinated Phenol, Inorganic-Zinc 1,3-bis (dihydroxymethyl)-5,5- 6440-58-O ##### 2298 Hydantoin dimethylhydantoin

1,3-dibromo-5,5- 77-48-5 6317 4036 Hydantoin dimethylhydantoin

1,3-dichloro-5,5- 118-52-5 37 Hydantoin dimethylhydantoin Fungicide, Herbicide US 2006/0276339 A1 Dec. 7, 2006 63

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class 1,3-Dichloro-5-ethyl-5- 8.9415-87-2 ##### 2264 Microbiocide, Hydantoin methylhydantoin Fungicide, Herbicide 1-bromo-3-chloro-5,5-dimethyl 16O79-88-2 6315 2080 Microbiocide, Hydantoin hydantoin Fungicide, Herbicide 1-Hydroxymethyl-5,5-dimethyl 116-25-6 ##### 2306 Fungicide, Hydantoin hydantoin Herbicide, Microbiocide 3-Bromo-1-chloro-5,5- 126-06-7 6322 NA92 Microbiocide, Hydantoin dimethylhydantoin Fungicide, Herbicide 3-Hydroxymethyl-5,5-dimethyl NA. 1478 NA22O NA219 Fungicide Hydantoin hydantoin Dimethylol dimethylhydantoin 6440-58-O ##### 2524 Fungicide, Hydantoin Herbicide, Microbiocide Acetalized polyvinyl alcohol NA 1185 46926 NA166 Microbiocide odine Compoun complexed with iodine Alkyl (29% C14, 29% C13, NA973 NA557 2063 Microbiocide odine Compoun 21% C12, 21% C15) poly(oxypropylene) poly (Oxyethylene)-iodine complex Alkyl (C12–C15)- NA972 NASS6 1734 Microbiocide odine Compoun poly(oxypropylene) poly(Oxyethylene)-iodine complex Alkyl (C12–C15) NA 1195 46918 NA168 Microbiocide odine Compoun poly(oxypropylene)poly(Oxyethylene)- iodine complex Alkyl (ethyl cycloimidinium) NA 1211 46906 NA. 169 Microbiocide odine Compoun 3-hydroxy-3-ethyl sodium alcoholate, 2-methyl sodium carboxylate-tridecyl polyoxyethylene ethanol Alkyl dimethyl 3,4- NA1198. 46907 NA168 Microbiocide, odine Compound, dichlorobenzyl ammonium Microbiocide Quaternary chloride Ammonium polyethoxypolypropoxypolyethoxyethanol Compound iodine complex * (50% C12, 30% C14, 1 Alkyl NA 1214 46925 NA. 170 Microbiocide Iodine Compound poly(oxypropylene)poly(Oxyethylene)- iodine complex *(43% C10, 30% C14, 12% C12, 10% C16, 5% C18) Butoxy polypropoxy 46901 1633 Microbiocide odine Compoun polyethoxy ethanol-iodine complex Diethanolamine myristate 53404–40-3 46910 NA406 Microbiocide odine Compoun iodine complex odophors 39392-86-4 NA213 NA 212 Microbiocide odine Compoun Nonyl phenoxy poly NA927 NA39 1610 Microbiocide odine Compoun (Oxyethylene) amine Sulfonate ethanol-iodine Nonyl phenoxy 35860-86-7 46903 870 Microbiocide odine Compound, polyoxyethylene ethanol-iodine Polyalkyloxy complex Compound Octylphenoxy polyethoxy 53404-04-9 46915 2172 Microbiocide, odine Compoun ethanol-iodine complex Fungicide, Herbicide Poly oxyethylene ethanol 82010-75-1 46924 2261 Microbiocide odine Compoun monoesters of 5- (and 6-) carboxy-4-hexyl-2- cyclohexene-1-octanoic acid, complex with iodine Poly propoxy poly ethoxy NA232 NA 453 1828 Microbiocide Iodine Compound ethanol, I2 complex Polyethoxy polypropoxy 26617-87-8 46904 1585 Microbiocide Iodine Compound polyethoxy ethanol-iodine complex US 2006/0276339 A1 Dec. 7, 2006 64

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Polyethoxy polypropoxy NA 1286 46909 NA174 Microbiocide odine Compoun polyethoxy ethanol-iodine complex Polyethoxypolypropoxypolyethoxyethanol NA 1287 46913 NA. 175 Microbiocide odine Compoun n-alkyl (54% C12, Quaternary 18% C14, 9% C16, 9% C18, Ammonium 5% C10, 5% C8) di(beta Compound hydroxyethyl) benzyl am Polyethylene glycol ether of 68439-47-4 46921 2121 Microbiocide odine Compoun linear secondary alcohol iodine complex Polyvinyl pyrrollidone-iodine 46914 1611 Microbiocide odine Compoun complex Sodium dodecylbenzene S3467-01-9 46920 1569 Microbiocide odine Compoun Sulfonate-iodine complex Sodium N-alkyl-N-palmitoyl NA290 NAS62 1568 Microbiocide odine Compoun taurate-iodine complex Sodium N-cyclohexyl-N- 53404-81-2 46919 2089 Microbiocide odine Compoun palmitoyl taurate-iodine complex Tetraglycine hydroperiodide 7097-60-1 46923 1923 Microbiocide odine Compoun Tridecylpoly(ethyleneoxy)ethanol S3404-05-0 46911 NA407 Microbiocide odine Compoun iodine complex Triethanolamine octylsulfate 82010-77-3 46922 NA 4.09 Microbiocide odine Compoun iodine complex 2-(4-chlorophenylmethyl)- 26530-09-6 ##### NA 12S Microbiocide Sothiazo Ole 3(2H)-isothiazolone 2-cyclohexyl-4,5-dichloro-4- S7063-29-3 ##### NA166 Insecticide Sothiazo Ole isothiazolin-3-one 2-cyclohexyl-4,5-dichloro-4- S7063-29-3 ##### NA938 Insecticide Sothiazo Ole isothioazolin-3-one 2-Methyl-3(2H)-isothiazolone, 57373-20-3 ##### NA895 Microbiocide Sothiazo Ole calcium chloride complex 2-methyl-4,5-trimethylene-4- 82633-79-2 ##### 5013 Microbiocide Sothiazo Ole isothiazolin-3-one 2-methyl-4-isothiazolin-3-one 2682-20-4 ##### Microbiocide Sothiazo Ole 3(2H)-chloro-2-methyl-3(2H)- 57373-19-0 ##### NA894 Microbiocide Sothiazo Ole isothiazolone, calcium chloride complex 4,5-dichloro-2-n-octyl-3(2H)- 64359-81-5 ##### 3982 Microbiocide, Sothiazo Ole isothiazolone Antifoulant 4-chloro-2-n-octyl-3(2H)- 64359-80-4 ##### NA 102 Microbiocide Sothiazo Ole isothiazolone 5-chloro-2-((4- ##### NA 12S Microbiocide Sothiazo Ole chlorophenyl)methyl)-3(2H)- isothiazolone, compol. With 2 ((4-chlorophenyl)methyl)- 3(2h)-isothiazolone (1:1) 5-chloro-2-(4- 66159-95-3 ##### NA 12S Microbiocide Isothiazolone chlorophenylmethyl)-3(2H)- isothiazolone 5-chloro-2-methyl-4- 26172-SS-4 ##### 2038 Microbiocide Isothiazolone isothiazolin-3-one 5-chloro-2-methyl-4- 55965-87-2 ##### NA 896 Microbiocide Isothiazolone isothiazolin-3-one calcium chloride with 2-methyl-4- isothazolin-3-one calcium chloride Kathon 886 (kathon biocide) S5965-84-9 ##### NA24 Microbiocide Isothiazolone Octhillinone 26530-20-1 99901 1881 Microbiocide, Isothiazolone Fungicide 2,4,6-triisopropyl phenol 376389 NA116 3492 NA Phenols 2,4-xylenol 105-67-9 86804 638 Solvent, Phenols Fungicide, Microbiocide 2,6-bis (1-methylheptadecyl)- NA 106 3069 Microbiocide Phenols p-cresol 2-tert-Amylphenol 87-26-3 64119 NAS38 Microbiocide Phenols 4-Hexylresorcinol 136-77-6 71.403 NA. 671 NA Phenols 4-Octylresorcinol 6565-70-4 714O2 NA. 670 NA Phenols 5-isopropyl-o-cresol 499-7S-2 22104 1877 Microbiocide Phenols US 2006/0276339 A1 Dec 7, 2006 65

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Butylated hydroxy toluene 128-37-0 221 OS 1309 Preservative Phenols Carbolic acid 108-95-2 64001 107 Microbiocide, Phenols Nematicide Coal tar phenols 1319-77-3 22101 1720 NA Petroleum derivative, Phenols Cresol 1319-77-3 NA219 NA218 Insect Phenols Repellent, Microbiocide Diisobutyl cresoxy ethoxy S3466-87-8 69 155 1643 Microbiocide Phenols ethyl dimethyl benzyl ammonium chloride-ortho phenylphenol ethoxynonyl phenol complex Diisopropyl cresol 31291-59-5 22107 NA. 176 Micro bioci Phenols Diisopropyl phenols NA. 170 NA329 3638 NA Phenols Hydroxymercury cresol 12379-66-7 46001 NA390 Micro bioci norganic-Mercury, Heavy metal, Phenols Isopropyl cresol 499-7S-2 22104 1161 Micro bioci Pheno S Isopropyl phenol 251 68-06-3 NA1SS 32S6 Micro bioci CO S Meta-cresol 108-39-4 22102 378 Micro bioci CO S Nonyl phenol 25154-52-3 3304 Adjuvant CO S o-cresol 95-48-7 NA374 31.13 Micro bioci CO S o-Phenylphenol, alkyl amine 82010-74-0 64107 NAS33 Micro bioci CO S , Inorganic zinc salt of * (100% C18) inc o-Phenylphenol, S3404-7 1-0 64-109 NAS34 Micro bioci (OIS tetradecylamine salt Octylphenol 271 93-28-8 64118 NA537 NA C (OIS Ortho-phenylphenol 90-43-7 64103 448 Micro bioci Phenols Ortho-phenylphenol, 52704-98-0 64116 890 Micro bioci Phenols ammonium salt Ortho-phenylphenol, potassium 13707-6S-8 64-108 935 Micro bioci Phenols Salt Ortho-phenylphenol, sodium 132-27-4 64104 248 Micro bioci Phenols Salt p-cresol 106-44-5 NA375 3114 Micro bioci CO p-Cresyl acetate 140-39-6 NA 186 NA 186 Micro bioci CO Para-tert-amylphenol 80-46-6 64101 900 Micro bioci CO Para-tert-amylphenol, 53404-18-5 64111 1056 Micro bioci CO potassium salt Para-tert-butylphenol 98-54-4 64113 1OOO Micro bioci C CO S Phenol, dodecyl-, mixed 271 93-86-8 NA 656 3323 NA Phenols isomers Phenol, ferrous salt NA 686 NA 126 1862 NA Phenols Phenols 64743-03-9 NA 189 NA 189 Micro bioci Phenols Herbicide Polyvinylpyrrollidone S3403-98-8 64110 NAS35 Micro bioci Phenols orthophenylphenol complex Propoxur phenol 4812-20-8 ##### NA 118 Breakdown Phenols product Resorcinol 108-46-3 714O1 3375 NA Phenols Sodium cresolate 34689-46-8 ##### NA142 Micro bioci Phenols Sodium para-tert-amylphenate 31366-95-7 64112 1541 Micro bioci Pheno S Fungicide Sodium para-tert-butylphenate 5787-50-8 64115 1540 Micro biocide Pheno Sodium phenate 139-02-6 640O2 2164 Micro biocide Pheno Thymol 89-83-8 804O2 991 Dye Pheno Xylenol (unspec. Or mixed 1300-71-6 86805 NA 837 NA Pheno from 086804) 2-(2-(p-(diisobutyl) phenoxy) 121-54-0 69122 66 Micro bioci Quaternary ethoxy) ethyl dimethyl Ammonium ammonium chloride Compound 2-(2-(p-(diisobutyl) phenoxy) 121-54-0 691.64 NA166 Micro bioci Quaternary ethoxy) ethyl dimethyl Ammonium ammonium chloride Compound 3-(trimethoxysilyl) propyl 27668-52-6 ##### 2127 Micro bioci Quaternary dimethyl octadecyl ammonium Ammonium chloride Compound 3-alkoxy (C12–C15)-2- 68187-63-3 ##### 2020 NA Quaternary hydroxypropyl trimethyl Ammonium ammonium chloride Compound US 2006/0276339 A1 Dec. 7, 2006 66

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Acylamido alkylbenzyl NA993 NA 705 1442 Algaecide, Quaternary dimethyl ammonium chloride Microbioci Ammonium Compoun Alkenyl (90% C18, 10% C16) NA. 1313 NA 123 1243 Microbioci Quaternary dimethyl ethyl ammonium Adjuvant Ammonium bromide Compoun Alkenyl dimethyl ethyl 6458-13-5 69102 NA 62O Algaecide, Quaternary ammonium bromide Microbioci Ammonium *(90% C18, 10% C16") Compoun Alkenyl dimethyl ethyl NA 1187 69198 NA. 167 Microbioci Quaternary ammonium bromide Ammonium *(90% C18, 10% C16") Compoun Alkyl (100% C14) dimethyl 139-08-2 69107 2373 Algaeci Quaternary benzyl ammonium chloride Microbioci Ammonium Compoun Alkyl (47% C12, 18% C14, NA986 69143 1970 Algaeci Quaternary 0% C18, 10% C16, 15% C8 C10) Microbioci Ammonium dimethylbenzy Compoun ammonium chloride Alkyl (50% C12, 30% C14, 8O23-53-8 69110 2027 Algaeci Quaternary 7% C16, 3% C18) dimethyl Microbioci Ammonium dichlorobenzyl ammonium Compoun chloride Alkyl (50% C12, 30% C14, NA987 69143 1850 Algaeci Quaternary 7% C16, 3% C18) Microbioci Ammonium dimethylbenzyl ammonium Compoun chloride Alkyl (50% C12, 30% C14, 8.045-21-4 69111 1849 Algaeci e, Quaternary 7% C16, 3% C18) Microbioci Ammonium dimethylethylbenzyl Compoun ammonium chloride Alkyl (50% C14, 40% C12, NA988 69143 1846 Algaeci Quaternary O% C16) dimethylbenzyl Microbioci Ammonium ammonium chloride Compoun Alkyl (50% C14, 40% C12, 68989-01-5 69171 324 Algaeci Quaternary O% C16) dimethylbenzyl Microbioci Ammonium ammonium saccharinate Compoun Alkyl (53% C12, 19% C14, 61789-71-7 69140 3535 Algaeci Quaternary 8.5% C16, 7% C8, 6.5% C10, Microbioci Ammonium 6% C18) dimethyl Compoun benzylammonium chloride Alkyl (58% C14, 28% C16, NA 989 69143 1912 Algaeci Quaternary 14% C12) dimethylbenzyl Microbioci Ammonium ammonium chloride Compoun Alkyl (58% C18, 40% C16, 68.391-03-7 691.63 2228 Microbioci Quaternary 1% C14, 1% C12) trimethy Ammonium ammonium chloride Compoun Alkyl (60% C14, 25% C12, 68424-85-1 691OS 1956 Algaeci Quaternary 15% C16) dimethylbenzyl Microbioci Ammonium ammonium chloride Compoun Alkyl (60% C14, 30% C16, NA976 69143 1847 Algaeci Quaternary 5% C12, 5% C18) Microbioci Ammonium dimethylbenzyl ammonium Compoun chloride Alkyl (61% C12, 23% C14, 68989-00-4 ##### 1960 Algaeci Quaternary 11% C16, 3% C10, 2% C8) Microbioci Ammonium dimethylbenzyl ammonium Compoun chloride Alkyl (61% C12, 23% C14, NA977 69143 1975 Algaeci Quaternary 11% C16, 5% C18) dimethyl Microbioci Ammonium benzyl ammonium chloride Compoun Alkyl (61% C12, 23% C14, NA978 69143 2060 Algaeci Quaternary 11% C16, 5% C8, C10, C18) Microbioci Ammonium dimethylbenzyl ammonium Compoun chloride Alky 61789-71-7 69140 2375 Algaeci (61% C12, 23% C14, 11% C16, 2.5% Microbioci Ammonium C8 & C10, 2.5% C18) Compoun dimethylbenzyl ammonium chloride US 2006/0276339 A1 Dec. 7, 2006 67

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Alky (65% C12, 25% C14, NA979 69143 1971 Algaecide, Quaternary 10% C16) dimethylbenzyl Microbioci Ammonium ammonium chloride Compoun Alky (67% C12, 25% C14, NA98O 69143 1853 Algaecide, Quaternary 7% C16, 1% C8, C10, C18) Microbioci Ammonium dime hylbenzyl ammonium Compoun chloride Alky (68% C12, 32% C14) NA 1190 ##### NA. 167 Algaecide, Quaternary dime hyl dimethylbenzyl Microbioci Ammonium ammonium chloride Compoun Alky (68% C12, 32% C14) 85409-23-0 691.54 1854 Algaecide, Quaternary dime hylethylbenzyl Fungicide, Ammonium ammonium chloride Microbioci Compoun (70% C18, 27% C16, 68.391-03-7 691.63 10 Microbioci Quaternary 3% C14) trimethyl ammonium Ammonium chloride Compoun (90% C14, 5% C12, 69110 1909 Algaeci Quaternary 5% C16) dimethy Microbioci Ammonium dichlorobenzyl ammonium Compoun chloride (90% C14, 5% C12, 68527-84-4 69146 2057 Algaeci Quaternary 5% C16) dimethyl ethyl Microbioci Ammonium ammonium bromide Compoun NA981 69143 1977 Algaeci Quaternary 5% C16)(90% dimethylbenzyl C14, 5% C12, Microbioci Ammonium ammonium chloride Compoun (93% C14, 4% C12, NA1031 69143 1991 Algaeci Quaternary 3% C16) dimethylbenzyl Microbioci Ammonium ammonium chloride Compoun (95% C14, 3% C12, 68424-85-1 691OS 3855 Algaeci Quaternary 2% C16) dimethyl benzyl Microbioci Ammonium ammonium chloride Compoun (95% C14, 3% C12, NA982 69184 215.2 Algaeci Quaternary 2% C16) dimethyl benzyl Microbioci Ammonium ammonium chloride dihydrate Compoun (95% C14, 3% C12, NA 1322 NAS83 3897 Algaeci Quaternary 2% C16) dimethyl benzyl Microbioci Ammonium ammonium chloride Compoun monohydrate Alky (98% C12, 2% C14) 53516-75-9 69112 1839 Algaeci Quaternary dime hyl 1-naphthylmethyl Microbioci Ammonium ammonium chloride Compoun Alkyl (C10–16) dimethyl amine 61788-90-7 NA 401 3896 Algaeci Quaternary oxide Microbioci Ammonium Compoun Alkyl (C14, C12, C16) NA985 NAS87 2374 Algaeci Quaternary dime hylbenzyl ammonium Microbioci Ammonium chloride Compoun Alky (C8-C18) bis (2- 61789-68-2 ##### 2031 Microbioci Quaternary hydroxyethyl) benzyl Ammonium ammonium chloride Compoun Alky (C8-C18) bis (2- NA 1196 69148 NA168 Algaecide, Quaternary hydroxyethyl) benzyl Microbioci Ammonium ammonium chloride Compoun Alky dimethyl cumenyl NA983 NAS84 1919 Algaecide, Quaternary ammonium chloride Microbioci Ammonium Compoun Alky dimethyl ethyl benzyl NA974 NAS8O 10O2 Microbioci Quaternary ammonium cyclohexyl Ammonium Sulfonate Compoun Alky dimethyl ethylbenzyl 71808-54-3 6913S 1722 Algaecide, Quaternary ammonium cyclohexyl Microbioci Ammonium Sulfamate Compoun dimethyl isopropyl NA975 69188 884 Microbioci Quaternary benzyl ammonium chloride Ammonium Compoun Alky monoethyoxyethanol, NA305 NA577 1045 Microbioci diethoxyethyl benzyl Ammonium ammonium chloride Compoun US 2006/0276339 A1 Dec. 7, 2006 68

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Alkyl morpholinium NA. 1523 NA 223 NA 223 Fungicide Quaternary ethosulphate (1% C14, 22% Ammonium C16, 77% C18) Alkyl trimethyl ammonium 68424-92-0 ##### 1827 Microbiocide bromides

Alkyl (68% C12, NA1068 NA. 159 S126 Algaecide 32% C14)dimethyl dimethylbenzyl ammonium chloride Alkyl bis(2- 91721-81-2 ##### NA113 NA hydroxyethyl)benzyl ammonium chloride * (57% C10, 20% C12, 11% C14, 9% C18, 2% C16, 1% C8) Alkyl dimethyl 3,4- NA 1197 ##### NA168 Algaecide, Quaternary ichlorobenzyl ammonium Microbiocide Ammonium hloride * (42% C12, 27% C14, Oll 13% C16, 18% C8 C18) Alkyl dimethyl 3,4- 68989-02-6 ##### NA112 Algaecide, Quaternary ichlorobenzyl ammonium Microbiocide Ammonium chloride * (50% C14, 40% C12, Oll 10% C16) Alkyl dimethyl 3,4- 921.29-28-7 691.82 NA648 Algaecide, Quaternary ichlorobenzyl ammonium Microbiocide Ammonium chloride * (55% C14, 23% C12, Oll 20% C16, 2% C18) Alkyl dimethyl 3,4- 68989-02-6 ##### NA 124 Algaecide, Quaternary ichlorobenzyl ammonium Microbiocide Ammonium chloride *(60% C14, 30% C16, Oll 10% C12) Alkyl dimethyl 3,4- 68989-02-6 6918O NA646 Algaecide, Quaternary ichlorobenzyl ammonium Microbiocide Ammonium chloride *(60% C12, 25% C14, Com Oll 15% C16) Alkyl dimethyl 3,4- 68989-02-6 ##### NA113 Algaecide, ichlorobenzyl ammonium Microbiocide Ammonium hloride *(63% C12, 23% C14, Com Oll 14% C16) Alkyl dimethyl 3,4- 921.29-28-7 691.96 NA 653 Algaecide, ichlorobenzyl ammonium Microbiocide Ammonium chloride *(65% C12, 22% C14, Com Oll 10% C16, 3% C18) Alkyl dimethyl 3,4- 68989-02-6 ##### NA114 Algaecide, ichlorobenzyl ammonium Microbiocide Ammonium *(68% C12, 27% C14, Com Oll y g 1 ) Alkyl dimethyl 3,4- 68568-47-8 ##### NA 124 Algaecide, ernary ichlorobenzyl ammonium Microbiocide Ammonium C l O e : (7 50% C12, 25% C14) Compoun Alkyl dimethyl 3,4- 68989-02-6 ##### NA 124 Algaecide, ernary ichlorobenzyl ammonium Microbiocide Ammonium C l O e (7 50% C12, 25% C14) Compoun Alkyl dimethyl 3,4- 68989-02-6 69145 NA 635 Algaecide, ernary ichlorobenzyl ammonium Microbiocide Ammonium C14, 5% C16, Compoun Alkyl dimethyl 3,4- 68989-02-6 ##### NA 115 Algaecide, Qua ernary ichlorobenzyl ammonium Microbiocide Ammonium hloride *(C12 65%, C14 25%, Compoun Alkyl dimethyl 3,4- NA1198. 46907 NA168 Microbiocide Iodine Compound, ichlorobenzyl ammonium Microbiocide Quaternary Ammonium polyethoxypolypropoxypolyethoxyethanol Compound iodine complex * (50% C12, 30% C14, 1 Alkyl dimethyl benzyl 71011-24-O ##### NA113 Algaecide, Quaternary ammonium bentonite * (as in Microbiocide Ammonium fatty acids of tallow) Compound US 2006/0276339 A1 Dec. 7, 2006 69

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Alkyl dimethyl benzy 122-18-9 69108 NA 623 Algaecide, ernary ammonium chloride *( Microbiocide Ammonium C16) Compoun Alkyl dimethyl benzy 122-19-0 ##### NA114 Algaecide, ernary ammonium chloride *( Microbiocide Ammonium C18) Compoun Alkyl dimethyl benzy 68.391-01-5 691.95 NA 652 Algaecide, ernary ammonium chloride Microbiocide Ammonium * (41% C14, 28% C12, 19% C18, Compoun 12% C16) Alkyl dimethyl benzy NA 1199 691.68 NA168 Algaecide, ernary ammonium chloride Microbiocide Ammonium *(47% C12, 18% C14, 15% (C5-C15), Compoun 10% C18, 10% C16) Alkyl dimethyl benzy 8001-54-5 69106 NA 622 Microbiocide, ernary ammonium chloride Algaeci Ammonium * (50% C12, 30% C14, 17% C16, Herbici Compoun 3% C18) Alkyl dimethyl benzy 68.391-01-5 ##### NA113 Algaeci ernary ammonium chloride * (55% Microbioci Ammonium C16, 27% C12, 16% C 14, 2% Compoun C18) Alkyl dimethyl benzy 68.391-01-5 69 69 NA 641 Algaeci ernary ammonium chloride Microbioci Ammonium * (55% C16, 20% C14, 20% C12, Compoun 5% C18) Alkyl dimethyl benzy NA 1200 69 41 NA168 Algaeci ernary ammonium chloride Microbioci Ammonium * (58% C14, 28% C16, 14% C12) Compoun Alkyl dimethyl benzy 68424-85-1 69 61 NA168 Algaeci ernary ammonium ch oride *(60% Microbioci Ammonium C14, 30% C16, 10% C 12) Compoun Alkyl dimethyl benzy NA 12O1 69 37 NA168 Algaeci ernary ammonium chloride Microbioci Ammonium *(60% C14, 25% C12, 15% C16) Compoun Alkyl dimethyl benzy S351 6-76-0 69 NA 621 Algaeci ernary ammonium chloride Microbioci Ammonium *(60% C14, 30% C16, 5% C18, Compoun 5% C12) Alkyl dimethyl benzy 68.391-01-5 69 89 NA 650 Algaeci Qua ernary ammonium chloride *(61% Microbioci Ammonium C12, 23% C14, 11% C 16, 5% Compoun C18) Alkyl dimethyl benzy NA 12O2 ##### NA168 Algaeci Qua ernary ammonium chloride *(61% Microbioci Ammonium C12, 23% 014, 11% C 6, 5% Compoun

Alkyl dimethyl benzy NA 1203 691.99 NA. 169 Algaeci ernary Microbioci Ammonium 12% C16) Compoun 68424-85-1 69157 NA. 164 Algaeci ernary Microbioci Ammonium 10% C16) Compoun 68.391-01-5 691.75 NA644 Algaeci ernary Microbioci Ammonium 7% C16, Compoun NA 1204 ##### NA. 169 Algaeci Qua ernary Microbioci Ammonium 7% C16, Compoun

NA 1205 69142 NA. 169 Microbioci ernary Ammonium 6% C16) Compoun Alkyl dimethyl benzy NA 12O6 ##### NA. 169 Algaecide, ernary l oride *(68% Microbioci Ammonium C12, 25% C14, 7% C1 6) Compoun Alkyl dimethyl benzy NA 12O7 691.94 NA. 169 Algaecide, ernary ammonium chloride Microbioci Ammonium *(90% C14, 5% C12, 5% C16) Compoun US 2006/0276339 A1 Dec. 7, 2006 70

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CAC lel Chemical Name CAS Number Code Code Use Type Chemical Class Alkyl dime hyl benzyl 68424-85-1 69158 NA 64 Algaecide, Quaternary ammonium c hloride Microbioci Ammonium *(93% C14, 4% C12, 3% C16) Compoun Alkyl dime hyl benzyl 68607-20-S ##### NA 14 Algaecide, Quaternary ammonium c hloride *(95% Microbioci Ammonium C16, 5% C18) Compoun Alkyl dime hyl benzyl NA 1208 ##### NA 69 Algaecide, Quaternary ammonium c hloride * (as in Microbioci Ammonium fatty acids o coconut oil) Compoun Alkyl dime hyl benzyl NA 1209 ##### NA 69 Algaecide, Quaternary ammonium c hloride *(C8-18) Microbioci Ammonium Compoun hyl benzyl 61790-41-8 ##### NA 14 Algaecide, Quaternary ammonium ion alkyl amine Microbioci Ammonium C16) **(C10, Compoun 8045-22-5 69109 NA 624 Algaecide, Quaternary dimethylbenzyl ammonium Microbioci Ammonium chloride * (50% C12, 30% C14, Compoun hyl ethyl 134595-54-3 691.86 NA 649 Algaecide, Quaternary ammonium bromide *(85% Microbioci Ammonium Compoun hyl ethyl 61788-99-6 ##### NA113 Algaecide, Quaternary romide *(mixed Microbioci Ammonium alkyl and alkenyl groups as in Compoun Soybean oil) hyl ethylbenzyl 68956-79-6 691.67 NA 640 Algaecide, Quaternary hloride Microbioci Ammonium *(60% C14, 30% C16, 5% C12, Compoun Alkyl dime hyl ethylbenzyl 37335-68-5 6913S NA633 Algaecide, Quaternary ammonium Microbioci Ammonium cyclohexylsu 886 Compoun * (50% C12, 30% C14, 17% C16, 3% C18) Alkyl trime hyl ammonium 1119-97-7 69153 NA 637 Microbioci Quaternary bromide *(95% C14, 5% C16) Ammonium Compoun Alkyl trime hyl ammonium 112-00-5 ##### NA113 Microbioci Quaternary chloride *(70% C12, 30% C14) Ammonium Compoun Alkyl trime hyl ammonium 680O2-63-1 691.97 NA 654 Microbioci Quaternary Cl oride *(70% C18, 27% C16, Ammonium 3% C14) Compoun Alkyl trime hyl ammonium 691.51 NA 636 Microbioci Quaternary chloride *(90% C18, 10% C16) Ammonium Compoun kyl trime hyl ammonium 61790-41-8 ##### NA 115 Microbioci Quaternary A. oride *(alkyl as in fatty Ammonium 8. ci dS of soybean oil) Compoun kyl trime hyl ammonium 61789-18-2 ##### NA109 Microbioci Quaternary oride * (as in fatty acids of Ammonium conut oil) Compoun kyl trime hyl ammonium 69139 NA 634 Microbioci Quaternary oride * derived from Ammonium cottonseed oi Compoun Alkyl-5-hy roxy-4-oxo NA 1189 ##### NA. 167 Microbioci Quaternary 2 (4H)-pyranylmethyl dimethyl Ammonium ammonium c hloride * (49% Compoun C12, 17% C 4, 17% C10, 10% C18, 9% C16, 8% C8) Alkyl-N,N-bis(2- 70750-47-9 ##### NA114 NA Quaternary hydroxyethy )methyl Ammonium ammonium chloride * (53% Compound C12, 19% C 4, 8.5% C16, 7.0% C8, 6.5 % C10, 6.0% C18) A. kyl-N-ethyl morpholinium NA 1213 69147 NA. 170 Fungicide, Quaternary e hyl sulfate Algaecide Ammonium 25% C16, 8% C18, 1% C14) Compound US 2006/0276339 A1 Dec. 7, 2006 71

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Alkyldimethylbenzyl NA 1368 NA 194 NA 193 Microbiocide, ernary ammonium chloride Herbicide Ammonium Oll Alkyldimethylethylbenzylammonium NA 1369 NA 194 NA 193 Microbiocide, ernary chloride Herbicide Ammonium Oll Alkyltrimethyl ammonium NA 1370 NA 194 NA 193 Microbiocide, ernary chloride Fungicide Ammonium Oll Alkyltrimethylbenzyl NA 1371 NA 194 NA 193 Herbicide ernary ammonium chloride Ammonium Oll Benzyl dimethyl octadecyl 122-19-0 ##### 1186 Microbiocide ernary ammonium chloride Ammonium Oll Benzyl (dodecylcarbamoyl)methyl) 100-95-8 691.59 NA638 Microbiocide ernary dimethyl ammonium Ammonium chloride Oll Benzyl-C12-14-alkyldimethyl 134058-54-1 69.192 SO69 Microbiocide ernary quaternary ammonium Ammonium compounds Oll Cetyl dimethyl ethyl 124-03-8 69156 122 Microbiocide ernary ammonium bromide Ammonium Oll Cetyl trimethyl ammonium S7-09-0 69117 116 Microbiocide, ernary bromide Herbicide Ammonium Oll Cetyl trimethyl ammonium 112-02-7 691.33 NA 632 Microbiocide ernary chloride Ammonium Oll Cetylcide (95% C16, 3% C14, 124-03-8 69156 2061 Microbiocide ernary 2% C12) Ammonium Oll Chlormeduat 70O3-89-6 NA 216 NA215 Plant Growth ernary Regulator Ammonium Oll Chlormeduat chloride 999-81-5 18101 1512 Plant Growth ernary Regulator Ammonium Com Oll Di (alkyl oxypropyl)dimethyl NA 1261 691.21 NA173 Algaecide, ernary ammonium chloride *(60% C8, Microbiocide Ammonium 40% C10) Com Oll Dialkyl (85% C18, 15% C16) 68514-95-4 NA355 197 Microbiocide, ernary dimethyl ammonium chloride Adjuvant Ammonium Com Oll Dialkyl dimethyl ammonium NA900 NA172 S181 Microbiocide ernary polynaphthylamine Ammonium Com Oll Dialkyl dimethyl ammonium 73398-64-8 69136 2230 Microbiocide ernary chloride * (47% C12, 18% C14, Ammonium O% C18, 9% C10, 8% C16, Com Oll Dialkyl dimethyl ammonium 73398-64-8 ##### NA114 Microbiocide Qua ernary hloride * (48% C12, 17% C14, Ammonium O% C18, 9% C16, 8% C8, 7% Com Oll

ialkyl dimethyl ammonium 68153-33-3 ##### NA113 Microbiocide ernary oride * (50% C12, 20% C14, Ammonium % C10, 10% C16, 5% C18) Com Oll alkyl dimethyl ammonium 6891O-56-5 69.177 NA 645 Microbiocide ernary oride * (50% C12, 30% C14, Ammonium Com Oll Dialkyl dimethyl ammonium 680O2-59-5 6912O NA 626 Microbiocide ernary chloride *(70% C18, 26% C16, Ammonium 4% C14) Com Oll Dialkyl methyl benzyl 73049-75-9 69119 NA 625 Algaecide, ernary ammonium chloride *(60% Microbiocide Ammonium C14, 30% C16, 5% C18, 5% Com Oll C12) US 2006/0276339 A1 Dec. 7, 2006 72

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Diallyl dimethyl ammonium 26062-79-3 ##### 5092 Adjuvant Quaternary chloride polymers Ammonium Compoun Dibenzyldimethylammonium NA 1440 NA213 NA213 Microbiocide Quaternary chloride Ammonium Compoun Dicoco dimonium chloride 61789-77-3 69 138 3140 Adjuvant Quaternary Ammonium Compoun Didecyl dimethyl ammonium 148788-SS-O 69208 NA 658 Microbiocide Quaternary carbonate and didecyl dimethyl Ammonium ammonium bicarbonate Compoun Didecyl dimethyl ammonium 148812-65-1 69208 NA 659 Microbiocide Quaternary carbonate and didecyl dimethyl Ammonium ammonium bicarbonate Compoun Didecyl dimethyl ammonium 7173-51-5 69149 1682 Microbiocide, Quaternary chloride Fungicide Ammonium Compoun Didecyl methyl benzyl 32426-1O-1 69170 NA 642 Microbiocide Quaternary ammonium chloride Ammonium Compoun Dihydrogenated tallow 61789-81-9 691SO 3153 Adjuvant Quaternary dimethyl ammonium Ammonium methosulfate Compoun Dilauryl dimethyl ammonium 3282-73-3 ##### NA112 Microbiocide Quaternary bromide Ammonium Compoun Dimethyl dicoco ammonium NA166 NA317 1945 Microbiocide Quaternary chloride Ammonium Compoun Dimethyl dioctadecyl NA 627 NA114 31.63 Adjuvant Quaternary ammonium bentonite Ammonium Compoun Dioctyl dimethyl ammonium SS38-94-3 69166 1710 Microbiocide, Quaternary chloride Algaecide, Ammonium Fungicide Compoun Distearyl dimonium chloride 107-64-2 ##### 3176 Adjuvant Quaternary Ammonium Compoun Dodecyl di(2-hydroxyethyl) 19379-90-9 691.81 NA647 Microbiocide Quaternary benzyl ammonium chloride Ammonium Compoun Dodecyl dimethyl 2,4,5- 53404-46-9 ##### NA113 Microbiocide Quaternary trimethylbenzyl ammonium Ammonium chloride Compoun Dodecyl dimethyl ammonium NA. 157 NA294 1008 Microbiocide Quaternary chloride Ammonium Compoun Dodecyl dimethyl benzyl 1964OO1 691.23 NA 627 Quaternary ammonium bromide Ammonium Compoun Dodecyl dimethyl benzyl 139-07-1 69124 1167 Quaternary ammonium chloride Ammonium Compoun Dodecyl dimethyl benzyl 22232-26-4 691.28 NA 629 Quaternary ammonium Ammonium cyclopentanecarboxylate Compoun Dodecyl dimethyl benzyl NA 1027 691.27 1446 Fungicide, Quaternary ammonium naphthenate Insecticide, Ammonium Fungicide Compoun Dodecyl dimethy 534-66-90-3 ##### NA113 Microbiocide Quaternary Erichlorobenzyl ammonium Ammonium chloride Compoun Dodecylbenzyl alkyl (70% C12, 87175-02-8 ##### 1038 Algaecide, Quaternary 30% C14) dimethyl ammonium Microbiocide Ammonium chloride Compoun Dodecylbenzyl octadecyl 29932-85-2 ##### NA113 Microbiocide Quaternary dimethyl ammonium chloride Ammonium Compoun US 2006/0276339 A1 Dec. 7, 2006 73

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Dodecylbenzyl trimethyl 12379-51-0 691.26 NA 628 NA ernary ammonium 2-ethylhexanoate Ammonium Compoun Dodecylbenzyl trimethyl 1330-85-4 6912S 918 Adjuvant, ernary ammonium chloride Microbiocide Ammonium Compoun Ecolyst NA1174 69089 NA. 16S Plant Growth ernary Regulator Ammonium Compoun Ethyl dimethyl stearyl 111-98-8 ##### NA 115 Microbiocide ernary ammonium bromide Ammonium Compoun Mepiqua 15302-91-7 NA2O3 NA2O2 Plant Growth ernary Regulator Ammonium Compoun Mepiquat chloride 24307-26-4 ##### 2075 Plant Growth ernary Regulator Ammonium Compoun Methyl dodecyl benzyl 1399-80-0 69129 895 Microbiocide ernary trimethyl ammonium chloride Ammonium Compoun Methyl dodecyl benzyl NA 619 NA112 2678 Microbiocide ernary trimethyl ammonium chloride Ammonium 80% and methyl Compoun Methyl dodecyl trimethyl NA 44 NA 83 2679 Microbiocide ernary ammonium chloride Ammonium Compoun Methyl dodecyl xylene bis NA 45 NA 84 896 Microbiocide ernary (trimethyl ammonium chloride) Ammonium Compoun Methyl trioctyl ammonium 5137-55-3 NA72 3291 Adjuvant ernary chloride Ammonium Compoun Morpholine dodecyl benzene 12O68-08-5 ##### 3.294 Microbiocide, ernary Sulfonate Adjuvant, Ammonium Fungicide, Compoun insecticide N-(3,4-dichlorobenzyl)-N- 102-30-7 ##### 1129 Microbiocide ernary dodecyl-N,N-dimethyl Ammonium ammonium chloride Compoun N-alkyl (92% C18, 8% C16)-N- 61791-34-2 69113 986 Fungicide, ernary ethyl morpholinium ethyl Microbiocide Ammonium sulfate Compoun N-alkyl (soza)-N-methyl NA281 NASSO 3020 Fungicide, ernary morpholinium sulfate Microbiocide Ammonium Compoun N-cetyl-N-ethyl morpholinium 78-21-7 69113 1792 Fungicide, ernary ethyl sulfate Microbiocide Ammonium Compoun N-Cetyl-N-ethyl morpholinium 78-21-7 ##### NA174 Fungicide ernary ethyl sulfate Ammonium Compoun N-Cetyl-N-ethylmorpholinium 78-21-7 691.87 NA172 Fungicide ernary ethyl sulfate Ammonium Compoun N-Dialkyl (60% C14, 30% C16, 68424-87-3 NA356 2070 Microbiocide ernary 5% C12, 5% C18) methyl Ammonium benzyl ammonium chloride Compoun N-isononyl-N,N-dimethyl 138698-36-9 692O7 5070 Microbiocide ernary decanaminium chloride Ammonium Compoun Octyl decyl dimethyl 32426-11-2 69165 1709 Microbiocide, ernary ammonium chloride Fungicide Ammonium Compoun Octyl dodecyl dimethyl 10361-1 6-7 691.90 1947 Microbiocide ernary ammonium chloride Ammonium Compoun Oleyl dimethyl ethyl 14351-44-1 69132 NA 631 Microbiocide Qua ernary ammonium bromide Ammonium Compoun US 2006/0276339 A1 Dec. 7, 2006 74

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Oxydiethylene bis (alkyl 68607-28-3 69173 1362 Microbiocide Quaternary dimethyl ammonium chloride), Ammonium alkyl derived from coconut oil Oll atty acids Polybromide form of NA1164 8711 NA. 163 Microbiocide Quaternary trimethylbenzyl ammonium Ammonium resin Oll Polyethoxypolypropoxypolyethoxyethanol NA 1287 46913 NA. 175 Microbiocide n-alkyl (54% C12, 8% C14, 9% C16, 9% C18, 5% C10, 5% C8) di(beta hydroxyethyl) benzyl am Polymeric quaternary NA. 1463 NA217 NA 216 Microbiocide, ammonium chloride Adjuvant

Polyduaternium-6 28301-34-0 NA767 2818 Adjuvant

Polytrimethyl vinyl benzyl 9017-80-5 NA 119 3769 Adjuvant ammonium chloride Quaternium-18 bentonite 68953-58-2 ##### 2996 Adjuvant

Soya ethyl morpholinium 61791-34-2 69113 3453 Fungicide, ethosulfate Microbiocide

Tetradecyl dimethyl benzyl 139-08-2 69107 1166 Algaecide, ammonium chloride Microbiocide

Tetraethyl ammonium 77-98-5 4215 NA76 NA Quaternary hydroxide Ammonium Com Oll 2-Mercaptobenzothiazole, zinc 155-04-4 51705 1449 Fungicide, Mercaptobenzothiazole, Salt Microbiocide norganic-Zinc 5-Chloro-2- 53404-93-6 51709 NA 427 Microbiocide, Mercaptobenzothiazole, mercaptobenzothiazole, Zinc Fungicide norganic-Zinc Salt Acetic acid, copper (2+) salt 142-71-2 NA 697 3013 NA norganic-Copper Alkyl-1-(2-aminoethyl)-2- NA 1188. 46606 NA. 167 Microbiocide norganic-Nickel, imidazoline acetate-nickel midazoline lfate complex luminum 7429-90-5 111 1042 NA norganic luminum acetate NA971 NAS48 3025 NA norganic luminum bicarbonate NA 1043 NA 140 3026 NA norganic luminum caprylate 6O28-57-5 NAS49 3027 NA norganic luminum chloride 7446-70-0 13901 3028 NA norganic luminum diacetate 142-03-0 NA113 3O29 NA norganic luminum hydroxide 21645-51-2 NA 129 2145 NA norganic luminum magnesium silicate NA 1018 NA 107 2378 Adjuvant norganic luminum oxide 1344-28-1 NAS40 3O3O NA norganic luminum phosphide 2O859-73-8 66SO1 484 Fumigant, norganic Fungicide, Fungicide luminum potassium sulfate 10043-67-1 ##### Herbicide, norganic insecticide luminum silicate 1302-76-7 NA131 2379 Adjuvant norganic luminum stearate 637-12-7 NA541 3O32 NA norganic luminum sulfate 10043-01-3 13906 1415 Plant Growth norganic Regulator, Molluscicide Ammonia 7664-41-7 22 insecticide, norganic Deer Repellent, Fungicide Ammonium alum 7784-26-1 NAS33 3037 Repellent norganic Ammonium alum NA 1216 985O1 NA. 170 Adjuvant norganic Ammonium arsenate 7784-44-3 136O1 238O Herbicide, norganic-arsenic, insecticide, Heavy metal Rodenticide Ammonium bicarbonate 1066-33-7 NAS34 pH Adjustment norganic Ammonium bisulfate 78O3-63-6 NA. 141 NA norganic US 2006/0276339 A1 Dec. 7, 2006 75

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Ammonium bromide 12124-97-9 352 3040 NA norganic Ammonium carbamate 1111-89-7 NA. 141 3O41 NA norganic Ammonium carbonate SO6-87-6 735O1 3O42 Fungicide, norganic Herbicide, Microbiocide, pH Adjustment Ammonium chloride 121.25-02-9 ##### 3O43 NA norganic Ammonium dichromate 2149701 683OS NA607 Wood norganic Preservative Chromium(VI), Heavy metal Ammonium ferric Sulfate 10138-04-2 NA537 3047 Herbicide norganic Ammonium fluosilicate 16919-19-0 75301 695 insecticide norganic Ammonium fluosilicate on 62449-69-8 753.11 NA 694 insecticide norganic silica gel Ammonium hydroxide 1336-21-6 5301 2381 Fungicide, pH norganic Adjustment, Herbicide, Microbiocide Ammonium nitrate 6484-52-2 76101 3052 Rodenticide, norganic Microbiocide Ammonium nitrite 13446-48-5 NA 700 Rodenticide, norganic Microbiocide Ammonium oxalate 1113-38-8 96.03 891 Microbiocide norganic Ammonium polysulfides 908O-17-5 76701 NA 707 insecticide, norganic Fungicide Ammonium sulfate 7783-20-2 1363 Herbicide, pH norganic Adjustment Ammonium thiocyanate 1762-95-4 25 Synergist norganic Ammonium thiosulfate 7783-18-8 892 insecticide, norganic Fungicide, Herbicide Anhydrous Zirconium (IV) 1314-23-4 79090 2204 NA norganic oxide Anilinocadmium dilactate 19651-91-3 NAS48 NA norganic-Cadmium, deavy meta Arsenic 7440-38-2 NA 121 710 Herbicide, norganic-arsenic, insecticide, deavy meta Rodenticide Arsenic acid 7778-39-4 40 Herbicide, norganic-arsenic, insecticide, deavy meta Rodenticide Arsenic disulfide S6320-22-0 6901 NA 98 Herbicide, norganic-arsenic, insecticide, deavy meta Rodenticide Arsenic pentoxide 1303-28-2 631 Fungicide, norganic-arsenic, insecticide, deavy meta Rodenticide, Herbicide Arsenic sulfide 12612-21-4 6901 NA99 Herbicide, norganic-arsenic, deavy meta Ro Arsenic trioxide 1327-53-3 7001 42 norganic-arsenic, deavy meta

Arsenic trisulfide 1303-33-9 6901 NA97 norganic-arsenic, deavy meta

ArSonic acid, ammonium salt S8829-95-1 ##### NA 105 norganic-arsenic, deavy meta

Asbestos 1332-21-4 993O1 2398 norganic Barium carbonate 513-77-9 75O1 3060 norganic Barium chloride 10361-37-2 NA. 141 3061 norganic Barium fluosilicate 1712S-8O-3 753O2 NA 688 norganic Barium metaborate 13701-59-2 11101 973 norganic Barium nitrate 10O22-31-8 NA 186 NA 18S norganic Barium polysulfide SO864-67-O 76704 NA 709 insecticide, norganic Fungicide Barium sulfate 7727-43-7 7502 2411 NA norganic US 2006/0276339 A1 Dec. 7, 2006 76

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Basic copper arsenate 6102-92-4 ##### NA132 Herbicide, norganic-arsenic, Insecticide, Heavy metal, Rodenticide norganic-Copper Basic lead silicate 534-66-66-3 48003 NA 417 NA norganic-Lead, Heavy metal Bentonite 302-78-9 NA496 1399 Adjuvant norganic Blast furnace slag NA239 NA477 2425 NA norganic Borax 3O3-96-4 11102 79 Insecticide, norganic Herbicide Bordeaux mixture NA240 NA478 8O Fungicide norganic-Copper Boric acid OO43-35-3 11 OO1 769 Insecticide norganic Boric acid (H4B6O11), Zinc 2447-61-9 ##### SO94 Fungicide norganic-Zinc salt(1:2) Boric oxide 3O3-86-2 11002 2090 Insecticide norganic Boron 7440-42-8 ##### 2426 NA norganic Boron sodium oxide 2179-04-3 11110 NA116 Insecticide norganic (B4Na2O7), pentahydrate Bromine 7726-95-6 8701 2296 Microbiocide norganic Bromine chloride 3863-41-7 2OSO4 2323 Microbiocide norganic Cadmium 7440-43-9 NA 460 2438 NA norganic-Cadmium, deavy meta Cadmium carbonate S13-78-0 12901 93 NA norganic-Cadmium, deavy meta Cadmium chloride 101 08-64-2 12902 94 NA norganic-Cadmium, deavy meta Cadmium cocoate 72869-63-7 NA459 NA norganic-Cadmium, deavy meta Cadmium oxide 1306-19-0 HHHH. NA130 NA norganic-Cadmium, deavy meta Cadmium perborate NA969 NA 461 NA norganic-Cadmium, deavy meta Cadmium sebacate 9394.99 12903 699 NA norganic-Cadmium, deavy meta Cadmium Succinate 141-00-4 12904 92 NA norganic-Cadmium, deavy meta Cadmium sulfate 1O124-36-4 1290S NA 123 NA norganic-Cadmium, deavy meta Cadmium yellow pigments NA967 NA 448 2439 NA norganic-Cadmium, deavy meta Calcareous shale NA 230 NA449 3595 NA norganic Calcium arsenate 7778-44-1 135O1 96 Herbicide, norganic-arsenic, insecticide, deavy meta Rodenticide, Molluscicide Calcium arsenite 53404-59-4 13602 NA 129 Herbicide, norganic-arsenic, insecticide, deavy meta Rodenticide Calcium carbide 75-20-7 NA 450 1571 Repellent norganic Calcium carbonate 471-34-1 1007 pH Adjustment, norganic Fungicide, Microbiocide, Herbicide Calcium carbonate, treated NA968 NA 451 2440 pH Adjustment, norganic Fungicide, Microbiocide, Herbicide Calcium chlorate 10137-74-3 NA 682 Defoliant, norganic Herbicide, Microbiocide Calcium chloride 10043-52-4 75605 920 Fungicide, norganic Herbicide, insecticide, Microbiocide, Molluscicide, Dessicant, Plant Growth Regulator Calcium cyanide 592-01-8 74001 176 Rodenticide Inorganic US 2006/0276339 A1 Dec. 7, 2006 77

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Calcium hydroxide 1305-62-O 99 pH Adjustment, norganic Fungicide, Microbiocide, Herbicide Calcium hypochlorite 7778-54-3 14701 326 Algaecide, norganic

Treatment Calcium nitrite 13780-06-8 NA 701 Rodenticide, norganic Microbiocide Calcium phosphate 101 O3-46-5 NA. 19S NA 195 Rodenticide norganic Calcium phosphate, tribasic 7758-87-4 764O1 1607 Rodenticide, norganic Fungicide, Herbicide, Microbiocide Calcium silicate 10101-39-0 1908 insecticide, norganic Adjuvant, Fungicide, Microbiocide Calcium sulfate 7778-18-9 2442 insecticide, norganic Herbicide Calcium sulfate dihydrate 10101-41-4 NA. 163 insecticide, norganic Herbicide Calcium thiosulfate 101.24-41-1 80101 930 insecticide, norganic Fungicide, Herbicide Calcium-zinc LN 193 NA 653 NA 120 3871 NA norganic-Zinc (complex) Calomel 1O112-91-1 100 Fungicide (norganic-Mercury, Heavy metal Carbon 7440-44-0 712 Water norganic Treatment, Rodenticide Carbon black pigment 1333-86-4 NA 442 2445 Dye norganic Carbon dioxide 124-38-9 166O1 22O7 Fumigant, norganic insecticide, Rodenticide Carbon disulfide 75-15-0 108 Fumigant, norganic Solvent, Breakdown product, Nematicide Chlorinated trisodium 568O2-99-4 ##### 2214 Water norganic phosphate (prior TSP & Treatment Sodium hypochlorite) Chlorine 7782-50-5 2OSO1 131 Microbiocide, norganic Water Treatment Chlorine dioxide 10049-04-4 2053 Microbiocide, norganic Water Treatment Chlorophyllin 11OO6-34-1 NA 191 NA 190 Fungicide, norganic-Copper, Microbiocide Botanical Chromated zinc chloride NA 1026 1187 insecticide, norganic Herbicide, Chromium(VI), Microbiocide norganic-Zinc, Heavy metal Chromic acetate 1066-30-4 21102 NA172 Wood norganic Preservative Chromium(VI), Heavy metal Chromic acid 7738-94-5 21101 1188 Wood norganic Preservative Chromium(VI), Heavy metal Chromic oxide 1308-38-9 21103 NA173 Wood norganic Preservative Chromium(VI), Heavy metal Chromium dioxide 12O18-01-8 NA411 2470 NA norganic Cobaltous sulfate 1O124-43-3 NA114 31.10 NA norganic Copper 7440-50-8 225O1 714 Fungicide norganic-Copper Copper (from triethanolamine 24403 NA 198 Algaecide norganic-Copper complex) Copper 2-ethylhexanoate 22221-10-9 2235 Fungicide norganic-Copper US 2006/0276339 A1 Dec. 7, 2006 78

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CAC lel Chemical Name CAS Number Code Code Use Type Chemical Class

Cop per 3-phenylsalicylate 12SO682 238O1 NA 91 NA norganic-Co e Cop per 8-quinolinoleate 1038O-28-6 240O2 159 Fungicide, norganic-Co e Microbiocide Cop per abietate 10248-55-2 23301 NA 84 Fungicide norganic-Co e Cop ber acetate 831 632 44002 147 Fungicide norganic-Co e Cop per ammonium acetate NA. 1544 NA225 NA225 Fungicide norganic-Co e Cop per ammonium carbonate 33113-08-S 22703 176 2 Fungicide norganic-Co e Cop per ammonium complex 16828-95-8 22702 355 O Fungicide norganic-Co e Cop ber arsenate 101 O3-61-4 228O1 NA 78 Herbicide, norganic-ars nic, insecticide, Heavy metal, Rodenticide norganic-Co e Cop per arsenite 10290-12-7 NA 77 Herbicide, norganic-ars nic, insecticide, Heavy metal, Rodenticide norganic-Co e Cop per as elemental from SO376-91-5 24.404 NA 99 NA norganic-Co e copper - etidronic acid complex Cop per beta cyclodextrin NA 1366 NA 193 NA 93 Fungicide norganic-Co e hy roxide Cop per bronze powder 7440-50-8 225O1 145 7 Antifoulant norganic-Co e Cop per carbonate, basic 1184-64-1 22901 60 Fungicide, norganic-Co e Algaecide, insecticide Cop per chloride (anhydrous) 1344-67-8 238O2 NA 192 NA norganic-Co e Cop per chloride (dihydrate) 1O125-13-0 23.701 NA 190 NA norganic-Co e Cop per citrate 10402-15-0 4400S 140 6 NA norganic-Co e Cop per citrate chelate NA961 NA387 3547 NA norganic-Co e Cop per complex with ammonia 6.7989-88-2 ##### NA 130 Fungicide norganic-Co e 8 ethylene diamine tetraacetate Cop per cresylate 12379-42-9 NA 181 Fungicide norganic-Co e Cop e 53404-24-3 NA349 NA norganic-Co e dehydroalbietylammonium 2 ethy hexanoate Cop per dihydrazinium sulfate 33271-65-7 SOSO4 NA norganic-Co e Cop per ethanolamine complex 14215-52-2 24409 Algaecide norganic-Co e Cop per ethanolamine NA 1044 NA. 146 355 1 Algaecide norganic-Co e CO plexes, mixed Cop per ethylenediamine 13426-91-0 9 Herbicide norganic-Co e CO plex Cop per gluconate chelate 814-91-5 23305 8 NA norganic-Co e Cop per hydrazinium sulfate S3433-02-6 50501 NA 418 Fungicide norganic-Co e Cop per hydroxide 20427-59-2 234O1 151 Fungicide, norganic-Co e Microbiocide, Nematicide Cop per hydroxide - NA 1017 NA 105 182 6 NA norganic-Co e trie hanolamine complex Cop per isodecanoate 84082-88-2 41221 NA354 NA norganic-Co e Cop per isononanoate 72915-82-3 41211 NA352 NA norganic-Co e Cop per isooctanoate 888S9-94-3 41204 NA350 NA norganic-Co e Cop per lactate 16O39-52-4 233O2 NA1 85 NA norganic-Co e Cop per linoleate 7721-15-5 23303 111 O NA norganic-Co e Cop per metaborate 39290-85-2 228O2 NA1 79 NA norganic-Co e Cop per monoethanolamine NA960 NA384 355 2 NA norganic-Co e CO plex Cop per naphthenate 1338-02-9 23102 153 Woo norganic-Co e Preservative, Insecticide, Fungicide, Dog and Cat Repellent Copper naphthenate 1338-02-9 6000 NA1 72 Woo Inorganic-Copper Preservative, Insecticide, Fungicide, Dog and Cat Repellent Copper naphthenate 1338-02-9 6300 NA1 72 Woo Inorganic-Copper Preservative, Insecticide, US 2006/0276339 A1 Dec. 7, 2006 79

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Fungicide, Dog and Cat Repellent Copper nitroacetate 22221-12-1 232O1 NA 183 NA norganic-Co e Copper octanoate 2O543-04-8 23.306 5225 Fungicide norganic-Co e Copper oleate 10402-16-1 23304 154 Fungicide norganic-Co e Copper oxide (ic) 1317-38-O 424O1 2231 Fungicide, norganic-Co e insecticide Copper oxide (ous) 1317-39-1 2S6O1 175 Fungicide, norganic-Copper insecticide Copper oxychloride 1332-40-7 8001 156 Fungicide norganic-Copper Copper oxychloride 1332-65-6 23SO1 NA 186 Fungicide norganic-Copper (Cu2Cl(OH)3) Copper oxychloride sulfate 8O12-69-9 23503 158 Fungicide norganic-Copper Copper oxysulfate 12158-97-3 23SO4 NA 188 NA norganic-Copper Copper oxysulfate 82010-79-5 23SO4 NA 189 NA norganic-Copper Copper pentachlorophenate 15773-35-0 63.01.1 NAS12 Wood Chlorinated Phenol, Preservative, norganic-Copper Microbiocide, Algaecide, Fungicide pper phosphate 101 O3-48-7 22902 NA 18O NA norganic-Co e pper phthalocyanine 147-14-8 NA381 2479 Dye norganic-Co e pper pyrophosphate 10102-90-6 697O1 NA 663 NA norganic-Co e Copper salts of fatty and rosin 9007-39-0 23104 155 Fungicide norganic-Co e d per salts of the acids of tall 61789-22-8 23103 NA 182 NA norganic-Copper

Copper silicate 1344-72-5 24301 NA 197 NA norganic-Copper Copper sodium sulfate NA 1023 NA 121 755 NA norganic-Copper phosphate complex Copper Sulfate (anhydrous) 7758-98-7 244.08 1778 Fungicide, norganic-Copper Algaecide, Molluscicide Copper sulfate (basic) 1344-73-6 81.01 162 Fungicide, norganic-Copper Algaecide, Molluscicide Copper sulfate (pentahydrate) 7758-99-8 161 Algaecide, norganic-Copper Fungicide, Insecticide, Water Treatment, Molluscicide, Nematicide Copper sulfate ethylene NA 1036 NA132 248O NA Inorganic-Copper diamine Copper Sulfate, monohydrate 10257-54-2 244O2 1789 Fungicide, Inorganic-Copper Algaecide, Molluscicide Copper sulfate, tri-basic NA1384 NA. 19S NA 194 Herbicide, Inorganic-Copper Algaecide, Fungicide, Water Treatment Copper triethanolamine NA 12S 1615 Algaecide norganic-Copper complex Copper-zinc chromate complex 1344-74-7 210O3 163 Fungicide, norganic Wood Chromium(VI), Preservative norganic-Zinc, Heavy metal, norganic-Copper Copper-zinc sulfate complex 55072-57-6 81.02 164 Fungicide norganic-Zinc, norganic-Copper Copper-zinc sulfate complex, NA959 NA382 1751 Fungicide norganic-Zinc, monohydrate norganic-Copper Crag turf fungicide 531 21 OO6 NA171 Fungicide norganic-Cadmium, (Cd—Cu—Ca—Zn-Chromate) norganic Chromium(VI), norganic-Zinc, Heavy metal US 2006/0276339 A1 Dec. 7, 2006 80

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Cryolite 15096-52-3 75101 173 Insectici de norganic Cuprammonium NA. 1382 NA. 19S NA 194 Fungicide norganic-Co e Cupric acetoarsenite 12002-03-8 22601 2485 Wood norganic-arsenic, Preservative Heavy metal, norganic-Co e Cupric ferric subsulfate 12168-2O-6 42402 NA365 Molluscicide norganic-Co e complex Cupric fluosilicate 12O62-24-7 75309 NA 692 Insectici de norganic-Co e Cupric gluconate S27-09-3 244OS 3117 Fungici e norganic-Co e Cupric nitrate 3251-23-8 76102 31.18 NA norganic-Co e Cuprous and cupric oxide, 82010-82-O 42403 NA366 NA norganic-Co e mixed Cuprous chloride (Cu2Cl2) 7758-89-6 ##### 5597 Fungici e norganic-Co e Cuprous iodide 7681-65-4 ##### NA902 NA norganic-Co e Cuprous sulfide 222O5-45-4 ##### NA 124 NA norganic-Co e Cuprous thiocyanate 1111-67-7 2S602 2108 Microbiocide norganic-Co e Device (Swimming pool NA. 1504 NA222 NA222 Algaeci norganic-Co e algaecide, copper generating) no guarantee required Device (Swimming pool NA1SOS NA222 NA222 Algaeci norganic algaecide, peroxide) no guarantee required Device (Swimming pool NA. 1506 NA222 NA222 Algaeci norganic algaecide, Salt in pool) no guarantee required Di-potassium salts of 13492-26-7 76416 NA 704 Fungici norganic phosphorous acid Microbiocide Diammonium phosphate 7783-28-0 NA819 654 Insectici norganic Fungici Herbici Microbiocide, pH Adjustment Diatomaceous earth 7631-86-9 72605 195 Insectici de, norganic Molluscicide Diatomaceous earth, other NA 115S NA173 901.9S Insectici de, norganic related Molluscicide Dihydrogen S4453-03-1 244O6 NA 200 NA norganic-Copper {ethylenediaminetetraacetato(4- )}cuprate(2-) Disodium EDTA-copper 14025-15-1 NA296 3173 NA norganic-Copper Disodium mono ethanolamine 53404-45-8 76410 1608 pH Adjustment, norganic phosphate Fungici Herbici Microbiocide Disodium octaborate 12008-41-2 11107 5053 Insectici de norganic anhydrous Disodium octaborate 1228O-03-4 11103 1800 Insectici de, norganic etrahydrate Herbici e Disodium phosphate 7558-79-4 76403 2534 pH Adjustment, norganic Fungici Herbici Microbiocide EDTA diammonium copper 7379-26-2 39117 1613 Algaeci e norganic-Copper Salt EDTA, copper complex 12276-01-6 391OS 1135 Algaeci e norganic-Copper EDTA, disodium zinc salt 14025-21-9 NA 274 31.89 NA norganic-Zinc Fatty acid* - silver complex 24927-67-1 72505 NA. 675 Microbiocide, norganic-Silver, *(100% C8) Fungici Heavy metal Herbici Feldspar 68476-25-S NA 118 3656 NA norganic Ferric chloride 7705-08-0 34901 3205 Herbici norganic Ferric oxide 1332-37-2 NA 104 32O6 NA norganic Ferric sulfate (anhydrous) 10O28-22-5 34902 1811 Herbici norganic Ferrous ammonium sulfate 1OO45-89-3 50506 1307 Herbici norganic Ferrous ammonium sulfate 7783-85-9 50509 NA 421 Herbici norganic hexahydrate Ferrous sulfate 7720-78-7 NA 120 289 Herbici norganic Molluscicide Ferrous sulfate (monohydrate) 17375-41-6 50507 1812 Herbici norganic Defoliant Ferrous sulfate heptahydrate 7782-63-O 505O2 1687 Herbici e norganic US 2006/0276339 A1 Dec. 7, 2006 81

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Granite NA 105 NA. 209 3663 NA norganic Graphite 7782-42-5 NA 210 3217 NA norganic Hydrated lime 13O2-62-O NA 194 3669 pH Adjustment, norganic Fungicide, Microbiocide, Herbicide riodic acid 10O34-85-2 46912 NA 4.08 NA norganic rocyanic acid 74-90-8 458O1 NA388 Fumigant norganic rofluoric acid 7664-39-3 456O1 NA387 NA norganic rogen chloride 7647-01-0 45901 329 Fumigant norganic Fungicide, Nematicide, pH Adjustment, Herbicide Hydrogen peroxide 7722-84-1 595 1794 Microbiocide, norganic Fungicide, Herbicide, Rodenticide Hydrogen sulfide 2147416 NA227 NA227 Breakdown norganic product y rophosphorous acid NA95 NA 189 2600 NA norganic y roxymercury cresol 12379-66-7 46001 NA390 Microbiocide norganic-Mercury, Heavy metal, Phenols ypochlorous acid 7790-92-3 ##### NA110 Water norganic Treatment, Microbiocide, pH Adjustment Hypoiodous acid 14332-21-9 ##### NA. 153 NA norganic norganic phosphate NA940 NA. 169 3671 pH Adjustment, norganic Fungicide, Herbicide, Microbiocide odic acid 7782-68-5 46902 NA405 NA norganic odine 7553-56-2 46905 718 Microbiocide, norganic Fungicide, Herbicide Oil 7439-89-6 NA 121 655 NA norganic ron oxide (Fe2O3) 1309-37-1 ##### NA870 Herbicide norganic ron oxide pigment NA942 NA. 175 2618 norganic ron phosphate 1OO45-86-0 34903 SO14 Molluscicide norganic Kaolin 1332-58-7 ##### 2629 insecticide, norganic Adjuvant, Fungicide, Microbiocide Lauric acid, barium cadmium 15337-60-7 NA 118 3676 Adjuvant norganic-Cadmium, Salt deavy meta Lead 7439-92-1 NA134 2638 NA norganic-Lead, deavy meta Lead acetate 301-04-2 48001 NA 415 NA norganic-Lead, deavy meta Lead arsenate 7784-40-9 13503 353 Herbicide, norganic-arsenic, Insecticide, norganic-lead, Rodenticide deavy meta Lead arsenate, basic 1327-31-7 13502 Herbicide, norganic-arsenic, Insecticide, norganic-lead, Rodenticide deavy meta Lead metasilicate NA938 NA. 138 1106 NA norganic-Lead, deavy meta Lead monoxide 101.90-SS-3 NA 123 1271 NA norganic-Lead, deavy meta Lead naphthenate 61790-14-5 48004 3296 NA norganic-Lead, deavy meta Lignin Sulfonic acid, copper NA933 NA 126 1925 NA norganic-Copper Salt Lignin Sulfonic acid, Zinc salt NA 1014 NA 102 1768 NA norganic-Zinc Lignin Sulfonic acid, zinc, NA 1030 NA 126 1771 NA norganic-Zinc manganese & iron salts Lime 1305-78-8 977 pH Adjustment, norganic Fungicide, Herbicide, Microbiocide US 2006/0276339 A1 Dec. 7, 2006 82

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Lime phosphate NA1432 NA 200 NA 199 Plant Growth norganic Regulator Lime-Sulfur 1344-81-6 76702 358 insecticide, norganic Fungicide Litharge 1317-36-8 48002 NA 416 NA norganic-Lead, Heavy metal Lithium carbonate SS4-13-2 NA 119 3924 pH Adjustment, norganic Fungicide, Microbiocide, Herbicide Lithium chloride 7447-41-8 ##### 5318 NA norganic Lithium hydroxide 1310-65-2 NA143 3267 pH Adjustment, norganic Fungicide, Herbicide, Microbiocide Lithium hypochlorite 13840-33-0 14702 922 Microbiocide, norganic Water Treatment Lithium perchlorate 2150251 NA 115 3268 NA norganic Magnesium aluminum 1327-43-1 75310 NA 693 insecticide norganic fluosilicate Magnesium arsenate 101 O3-50-1 13504 NA 126 Herbicide, norganic-arsenic, insecticide, Heavy metal Rodenticide Magnesium carbonate 546-93-0 73503 2654 pH Adjustment, norganic Fungicide, Microbiocide, Herbicide Magnesium chlorate 10326-21-3 ##### NA 155 Defoliant, norganic Herbicide, Microbiocide Magnesium chloride 7786-30-3 13902 Molluscicide, norganic Herbicide,

Magnesium chloride, 7791-18-6 NA110 norganic hexahydrate

Magnesium fluosilicate 6949-65-8 75304 norganic Magnesium lime NA931 NA111 norganic Magnesium nitrate O377-60-3 NA 115 norganic Magnesium oxide 309-48-4 9235 norganic

Magnesium phosphide 2057-74-8 66504 2085 Fumigant, norganic Rodenticide Magnesium silicate 343-88-0 NA 68O insecticide, norganic Adjuvant, Fungicide, Microbiocide Magnesium silicate, hydrous 4807-96-6 NA113 2658 Adjuvant norganic Magnesium sulfate 7487-88-9 50503 1339 Molluscicide, norganic Adjuvant Malachite (copper equivalent 319-53-5 ##### NA 155 NA norganic-Copper 57%) Mancozeb 22331 OO 14504 211 Fungicide Dithiocarbamate, norganic-Zinc Maneb and nickel sulfate 8OOS-46-7 ##### NA. 158 Fungicide Dithiocarbamate, hexahydrate (014505 + 050505) norganic-Nickel Manganese (II) oxide 1344-43-O NA 104 3274 NA norganic Manganese arsenate 7784-38-5 13506 NA 127 Herbicide, norganic-arsenic, Insecticide, Heavy metal Rodenticide Manganese carbamate NASS NA 103 3273 NA norganic Manganese sulfate 7785-87-7 NA 105 658 NA norganic Manganous oxide 1344-43-O NA143 3275 NA norganic Mercuric acetate 1600-27-7 S2104 NA 441 NA norganic-Mercury, Heavy metal US 2006/0276339 A1 Dec 7, 2006 83

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Mercuric chloride 7487-94-7 S2001 372 Fungicide norganic-Mercury, deavy meta Mercuric dimethyl 15415-64-2 709 Microbiocide norganic-Mercury, dithiocarbamate deavy metal, Dithiocarbamate Mercuric iodide 7774-29-O S2003 NA438 NA norganic-Mercury, deavy meta Mercuric oleate 1191-8O-6 52105 3.276 NA norganic-Mercury, deavy meta Mercuric oxide 21908-53-2 S2102 955 Fungicide norganic-Mercury, deavy meta Mercury 7439-97-6 S2301 NA26 NA norganic-Mercury, deavy meta Mercury naphthenate 1336-96-5 S2101 NA439 Wood norganic-Mercury, Preservative, deavy meta Insecticide, Fungicide Mercury pentanedione 14024-55-6 S2103 NA 440 NA norganic-Mercury, deavy meta Mercury phenate 588-66-9 S2106 NA 442 NA norganic-Mercury, deavy meta Metallic silver 7440-22-4 2125 Microbiocide, norganic-Silver, Fungicide, deavy meta Herbicide Metiram 146O1 493 Fungicide Dithiocarbamate, norganic-Zinc Mica 12003-33-2 NA 118 3690 NA norganic Mixed copper chelates or NA. 1437 NA213 NA 212 Fungicide (norganic-Copper complex blend of copper salts Molybdenum 7439-98-7 NA. 152 3903 NA norganic Molybdic acid, disodium salt 7631-95-O NA135 2690 NA norganic Mono-potassium salts of 13977-65-6 76416 NA 705 Fungicide, norganic phosphorous acid Microbiocide Monosodium phosphate 7558-80-7 76409 1772 pH Adjustment, norganic Fungicide, Herbicide, Microbiocide N-(2-hydroxyethyl) ethylene NA 1025 NA 122 1130 NA norganic-Copper diamine triacetic acid, copper Salt Neodecanoic acid, copper salt SO315-14-5 97503 NA854 NA norganic-Copper Nickel 7440-02-0 NA 121 762 NA norganic-Nickel Nickel diethylhexyl acid NA928 NAS3 3696 NA norganic-Nickel phosphate complex Nickel sulfate (anhydrous) 7786-81-4 50508 NA 42O Fungicide norganic-Nickel Nickel sulfate hexahydrate 10101-97-0 50505 NA 419 Fungicide norganic-Nickel Nitric acid 7697-37-2 45951 NA389 NA norganic Nitric acid technical 7697-37-2 NA47 2703 NA norganic Nitrogen trichloride 10O2S-85-1 NASO 2705 NA norganic Nitrogen, liquified 7727-37-9 ##### 2267 Insecticide norganic Nitrous oxide 10O24-97-2 NA 115 33O2 NA norganic Noury dry cobalt 12% NA 21 NA33 2712 NA norganic Nuxtra manganese 12% NA 746 NA135 2719 NA norganic catalyst o-Phenylphenol, alkyl amine 82010-74-0 64107 NAS33 Microbiocide Phenols, Inorganic zinc salt of * (100% C18) Zinc Oxalic acid 144-62-7 96O1 899 Microbiocide norganic Ozone 10O28-15-6 NA228 NA228 Water norganic Treatment, Microbiocide p-tert S3433-01-5 S2002 NA437 Microbiocide norganic-Mercury, Octylphenoxyethoxyethyl Heavy metal dimethylbenzyl ammonium mercuric chloride Paris green 12002-03-8 22601 460 Wood norganic-Arsenic, Preservative norganic-Copper, Heavy metal Penta potassium triphosphate 13845-36-8 76412 3319 NA norganic Pentachlorophenol, Zinc salt 2917-32-O 63008 NAS10 Wood Chlorinated Phenol, Preservative, norganic-Zinc Microbiocide, US 2006/0276339 A1 Dec. 7, 2006 84

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Algaecide, Fungicide Perboric acid, sodium salt NA1160 NA174 54.52 insecticide norganic Perboric acid, sodium salt, 10332-33-9 11105 5052 insecticide norganic monohydrate Perchloric acid, calcium salt 13477-36-6 NA. 670 3321 NA norganic Perlite NA 756 NA 136 2767 NA norganic Peroxyacetic acid 79-21-0 632O1 2291 Microbiocide, norganic Fungicide, Herbicide, Rodenticide Peroxydisulfuric acid 13445-49-3 NAS24 NA norganic Phosphine 78O3-51-2 3541 Fumigant, norganic insecticide Phosphoric acid 7664-38-2 76001 871 Fungicide, pH norganic Adjustment, Herbicide, Microbiocide Phosphoric acid, disodium salt, 10O28-24-7 76415 NA 703 pH Adjustment, norganic dihydrate Fungicide, Herbicide, Microbiocide Phosphoric acid, 7778-77-0 76413 2777 pH Adjustment, norganic monopotassium salt Fungicide, Herbicide, Microbiocide Phosphoric acid, trisodium salt 568O2-99-4 ##### 3851 Water norganic (chlorinated) Treatment Phosphorous acid 13598-36-2 76002 NA699 Fungicide, norganic Microbiocide Phosphorus 7723-14-0 66SO2 513 NA norganic Phosphorus pentasulfide 1314-56-3 NA 640 2778 NA norganic yoxin D Zinc salt 146659-78-1 ##### NA 129 Fungicide norganic-Zinc assium aluminum silicate NA996 NA 774 3344 Adjuvant norganic assium aluminum sulfate 7784-24-9 NA 775 3345 insecticide, norganic Herbicide assium arsenite 1O124-50-2 13605 NA131 Herbicide, norganic-arsenic, insecticide, Heavy metal Rodenticide assium arsenite 13464-35-2 13605 NA132 Herbicide, norganic-arsenic, insecticide, Heavy metal Rodenticide assium azide 2O762-6O-1 ##### NA898 NA norganic assium bicarbonate 298-14-6 73508 5037 Fungicide norganic assium bifluoride 7789-29-9 752O3 NA687 NA norganic assium bisulfate 7646-93-7 5605 1860 pH Adjustment, norganic Fungicide, Herbicide, Microbiocide assium bromide 21381 64 13903 1090 Microbiocide norganic assium carbonate S84-08-7 73.504 1620 pH Adjustment, norganic Fungicide, Microbiocide, Herbicide assium chlorate 696616 73303 3347 Defoliant, norganic Herbicide, Microbiocide assium chloride 7447-40-7 13904 NA 137 NA norganic assium chromate 7789-00-6 68301 700 Wood norganic Preservative Chromium(VI), Heavy metal assium cyanate 590-28-3 680O2 NA 6OO NA norganic assium cyanide 151-SO-8 ##### 497 Rodenticide norganic assium dichromate 7778-50-9 68302 2167 Wood norganic Preservative Chromium(VI) assium hexafluoroarsenate 17029-22-0 ##### NA. 160 NA norganic-arsenic, Heavy metal assium hydroxide 1310-58-3 1306 pH Adjustment, norganic Fungicide, Herbicide, Microbiocide US 2006/0276339 A1 Dec. 7, 2006 85

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Potassium hypochlorite 7778-66-7 ##### NA110 Microbiocide norganic Potassium iodate 2138.256 75703 NA 696 NA norganic Potassium iodate (KHCIO3)2) 13455-24-8 75704 NA 697 NA norganic Potassium iodide 7681-11-0 75701 10O3 Microbiocide norganic Potassium mercuric iodide 7783-33-7 52107 NA 443 NA norganic-Mercury, Heavy metal Potassium monoperSulfate 10361-76-9 ##### NA 104 NA norganic Potassium nitrate 7757-79-1 76103 726 Rodenticide, norganic Microbiocide Potassium nitrite 77S8-09-0 3356 Rodenticide, norganic Microbiocide Potassium permanganate 7722-64-7 498 Fungicide, norganic Algaecide, Molluscicide, Microbiocide Potassium peroxydisulfate 7727-21-1 63602 1028 Microbiocide, norganic Fungicide, Herbicide, Rodenticide Potassium peroxymonosulfate 10OS8-23-8 63604 1859 Microbiocide, norganic Fungicide, Herbicide, Rodenticide Potassium peroxymonosulfate 37222-66-5 NAS27 Microbiocide, norganic Sulfate, Fungicide, (2KHSO5.KHSO4.K2SO4) Herbicide, Rodenticide Potassium peroxymonosulfate 70693-62-8 NAS28 Microbiocide norganic Sulfate, Fungicide, (2KHSO5.KHSO4.K2SO4) Herbicide, Potassium phosphate 7778-53-2 3358 norganic

Potassium phosphate, dibasic 21384.38 ##### 3359 pHAdjustment, norganic Fungicide, Herbicide, Microbiocide Potassium phosphite NA. 1S6S NA 229 5766 Fungicide norganic Potassium phosphonate NA. 1S63 NA227 NA227 Fungicide norganic (phosphorous acid equivalent) Potassium polysulfide 37199-66-9 76703 NA 708 insecticide, norganic Fungicide Potassium pyrophosphate 7320-34-5 76408 1175 pH Adjustment, norganic Fungicide, Herbicide, Microbiocide Potassium silicate 1312-76-1 72606 2826 insecticide, norganic Adjuvant, Fungicide, Microbiocide Potassium sulfate 7778-80-5 S603 3362 insecticide, norganic Herbicide Potassium sulfite 101.17-38-1 NA 785 3364 Fungicide norganic Potassium tetraborate 1332-77-O NA 144 3365 insecticide norganic Potassium tetrathionate 13932-13-3 75903 NA 698 insecticide, norganic Herbicide Potassium thiocyanate 333-20-0 682O1 NA 605 insecticide norganic Potassium thiosulfate 10233-OO-8 80102 NA 773 insecticide, norganic Fungicide, Herbicide Potassium triiodide 12298-68-9 46917 SO66 Microbiocide norganic Propineb 12071-83-9 ##### NA 155 Fungicide, Dithiocarbamate, Microbiocide norganic-Zinc Pumice 1332-09-8 NA1SO 3777 NA norganic Quartz sand NA 1363 NA 193 NA 192 nSect norganic Repellent Rock powder NA 1375 NA 194 NA 194 NA norganic Selenium and compounds 7782-49-2 72001 NA31 NA norganic Selenium disulfide 7488-56-4 72003 NA. 673 NA norganic US 2006/0276339 A1 Dec. 7, 2006 86

TABLE 1-continued Cytotoxic agents and other active ingredients

U.S. EPA PC CA Chem Chemical Name CAS Number Code Code Use Type Chemical Class Shale NA459 NA821 3794 NA norganic Silica aerogel 63.231-67-4 726O2 529 Insecticide, norganic Adjuvant, Fungicide, Microbiocide Silica gel 63.231-67-4 3557 Insecticide, norganic Adjuvant, Fungicide, Microbiocide Silica hydrate NA 461 NA824 2853 NA norganic Silica, crystalline-fused 60676-86-O NA 823 2851 NA norganic Silica, crystalline-quartz NA. 138 2852 NA norganic Silicic acid 1343-98-2 NA 825 3556 NA norganic Silicon dioxide fresh water NA. 1524 NA 223 NA 223 Insecticide norganic fossils Silver acetate 563-63-3 72507 NA. 676 Microbiocide, norganic-Si ver, Fungicide, deavy meta Herbicide Silver carbonate 534-16-7 72509 NA. 678 Microbiocide, norganic-Si ver, Fungicide, deavy meta Herbicide Silver chloride 7783-90-6 72506 2324 Microbiocide, norganic-Si ver, Fungicide, deavy meta Herbicide Silver copper Zeolite 13O328-19-7 ##### NA110 Microbiocide norganic-Si ver, deavy meta norganic-Copper Silver fluoride 7775-41-9 NA. 674 Microbiocide (norganic-Si ver, Fungicide, deavy meta Herbicide Silver iodide, colloidal 7783-96-2 NA 124 1556 Microbiocide, norganic-Si ver, Fungicide, deavy meta Herbicide Silver nitrate 7761-88-8 72503 2856 Microbiocide, norganic-Si ver, Fungicide, deavy meta Herbicide, Plant Growth Regulator Silver orthophosphate 7784-09-0 72510 NA. 679 Microbiocide, norganic-Si ver, (Ag3PO4) Fungicide, deavy meta Herbicide Silver oxide (Ag4O4) 1301-96-8 ##### NA 111 Microbiocide, norganic-Si ver, Fungicide, deavy meta Herbicide Silver oxide (Ag4O4) 1SS645-89-9 ##### NA 111 Microbiocide, norganic-Si ver, deavy meta

Silver sodium hydrogen NA1166 72560 NA. 164 Microbiocide norganic-Si ver, Zirconium phosphate deavy meta (Ag0.18NaO.57HO.25Zr2(PO4)3) Silver thiocyanate 1701-93-5 682O3 NA 606 norganic-Si ver, deavy meta

Silver thiuronium acrylate copolymer S3404-00-5 72.701 NA 681 norganic-Si ver, deavy meta

Silver Zeolite 13O328-18-6 ##### NA 12S norganic-Si ver, deavy meta Silver zinc zeolite 13O328-20-0 ##### NA 111 norganic-Si ver, norganic-Zinc, deavy meta Silver, ionic 14701-21-4 NA. 169 5150 Microbiocide, norganic-Si ver, Fungicide, deavy meta Herbicide Soapstone NA465 NA 829 3797 NA norganic Sodium 7440-23-5 NA 830 2858 NA norganic Sodium acid phosphate 7558-80-7 76409 1413 pH Adjustment, norganic Fungicide, Herbicide, Microbiocide