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ORGANIZERS ORGANIZERS

The State Corporation for Space Activities «» is a Russian corporation that manages The Russian Academy of Sciences — is the State Academy of Sciences of the Russian the country’s space industry, created in 2015 by transforming the Federal Space Agency» Roscosmos Federation, the country’s largest center for basic research. The main purpose of the Russian « at the initiative of Deputy Prime Minister of the Russian Federation Dmitry Olegovich Rogozin. Academy of Sciences is to organize and conduct fundamental and applied scientifi c «Roscosmos» originates in the Ministry of General Mechanical Engineering of the USSR and is its research on the problems of natural, technical, humanitarian and social sciences, aimed at legal successor, as well as the Federal Space Agency «Roscosmos», the Russian Space Agency, the obtaining new knowledge about the laws of the development of nature, society, and man Russian Space Agency under the Government of the Russian Federation, the Russian Aviation and and contributing to the technological, economic, social and cultural development of . Space Agency. It includes enterprises and scientifi c organizations established in the Soviet era. The RAS is called upon to fulfi ll an important mission of ensuring the freedom of scientifi c In May 2015, the State Duma in the fi rst reading adopted a package of bills introduced by the creativity for the benefi t and prosperity of the country. As the highest scientifi c organization president on the creation of the state corporation «Roscosmos». Deputy Prime Minister Dmitry in Russia, the Russian Academy of Sciences participates in the coordination of basic research Rogozin, speaking to the deputies, said that the main task of the new space structure is «to ensure carried out at the expense of the federal budget by scientifi c organizations and educational the unity of management of the rocket and space industry.» institutions of higher professional education. Roscosmos performs the functions of ensuring the implementation of state policy and legal In the course of the reform of the system of Russian state Academies of Sciences, in September regulation, providing state services and managing state property in the fi eld of space activities. 2013, two other academies were joined to the Russian Academy of Sciences — the Russian Academy of Medical Sciences (RAMS) and the Russian Academy of Agricultural Sciences The main activities of the corporation are: manned , planetary exploration, solar (RASKHN). To date, taking into account the members of the former RAMS and RASKHN, exploration, astrophysics and the creation of artifi cial Earth satellites. One of the important activities who received the status of members of the Russian Academy of Sciences as a result of the of the corporation is the development of tourism, both on earth and in space. infusion of these academies into the Russian Academy of Sciences, the Russian Academy of www.roscosmos.ru Sciences has 1,979 members — Russian scientists, including 864 academicians (including 47 women) and 1,115 corresponding members (including 110 women). In addition, 481 foreign scientists are currently a foreign member of the Russian Academy of Sciences. The International Academy of Astronautics — is an international public organization that unites In May 2018, the Federal Agency for Scientifi c Organizations was abolished, and its leading scientists and engineers working in the fi eld of space research. It was founded in 1960 on management functions were transferred to the newly created Ministry of Science and the initiative of Theodor von Karman, one of the founders of aerodynamics and rocket technology. Higher Education of the Russian Federation. An active role in the creation of the Academy was played by L. I. Sedov, who for a number of years www.ras.ru was its vice-president. Recognized by the UN in 1996. The purpose of the Academy is to promote the exploration of and its use for peaceful purposes. The scientifi c journal «Acta Astronautica» is published under the auspices of the Academy. Currently (2016), the Academy has 1,200 members from 80 The Institute of Medical and Biological Problems (IMBP) was established in 1963 on countries, including two categories: Corresponding Members and full Members. They included the initiative of academicians M. V. Keldysh and S. P. Korolev to conduct research and representatives of Russian science and technology. The International Academy of Astronautics development work on medical and biological support for manned space objects and basic organizes annually the International Astronautical Congress (together with the International research in the fi eld of space biology and medicine. Since 1994, the Institute has the status Astronautical Federation and the International Institute of ), as well as about 20 of the State Scientifi c Center of the Russian Federation, since 2001 it has been part of the conferences and symposiums on space research. Under the auspices of the Academy, there are system of scientifi c institutions of the Russian Academy of Sciences. about 30 working groups that study various aspects of astronautics — from solar physics to the The State Research Center of the Russian Federation-IMBP RAS has a highly qualifi ed staff , psychology of behavior in space. Several dozen Russians are members of the academy: scientists, a developed experimental base; a Special Design Bureau for experimental equipment cosmonauts, designers. Anatoly Perminov is the Vice-President of the Academy for Science from has been established at the Institute. Since 1967, the Institute has published the journal 2011 to the present. In 2008, the fi rst joint conference was held with the Russian Academy of «Aerospace and Environmental Medicine». Cosmonautics named after K. E. Tsiolkovsky. International scientifi c and technical relations of the SSC RF-IBMP RAS are carried out within https://iaaspace.org the framework of cooperation with space agencies and scientifi c institutions of the USA, , , , , Austria, , Bulgaria, Hungary and a number of other countries. The Ministry of Science and Higher Education of the Russian Federation is the executive www.imbp.ru authority that develops and implements the state policy and legal regulation in the fi eld of higher education and respective additional professional education, scientifi c, technical and innovative activity, nanotechnologies, development of federal centres of science and high technologies, state scientifi c centres and scientifi c cities, intellectual property (excluding legal regulation of issues related to control, supervision and providing state services in the fi eld of protection of inventions, models, industrial samples, software, databases and topologies of integral microcircuits including those that are part of the unifi ed technology, trademarks, service signs, geographical indications, names of product origin), in the fi eld of social support and social protection of students. https://minobrnauki.gov.ru 4 5

HONORARY CHAIRS Members: J. Fogarty, NASA, USA Representative of the Ministry of Science and Higher J.Robinson, NASA, USA Education, Russia B. Corbin, NASA, USA V. Medvedev J. Hayes, NASA, USA I. Chugueva C. Kundrot, NASA, USA A. Romanov C. Mukai, JAXA/Kao Corporation, Japan D. Pospekhov Y. Deng, BIT, F. Zhuang, IAA/BUAA, China A. Bloshenko, Roscosmos, Russia C. Kourtidou-Papadeli, IAA /AUTH, Greece S. Krikalev, Roscosmos, Russia D. Prunariu, IAA/Romanian Academy, Romania P. Vlasov, GCTC, Russia Ch. Feichtinger, IAF, France J.-M. Contant, IAA, France D. Rogozin, Roscosmos, Russia I. Ozar, RSC “Energia”, Russia P. Gräf, DLR, Germany V. Soloviev, RSC “Energia”, Russia L. Suchet, CNES, France V. Tkachuk, RAS, Russia HONORARY ORGANIZING COMMITTEE J. Ngo-Anh, ESA, France V. Dubinin, TSNIImash, Russia M. Braun, DLR, Germany O. Kotov, ASE/IBMP, Russia J. Jordan, DLR, Germany W. Paloski, NASA, USA S. Al Marri, KFU, UAE

LOCAL ORGANIZING COMMITTEE

Chairperson — S. Ponomarev, IBMP, Russia

Members:

A. Perminov, IAA, Russia S. Saveliev, A. Grigoriev, RAS/IBMP, Russia A. Romanov, IBMP, Russia IAF/Roscosmos, Russia A. Rybalov, IBMP, Russia T. Semenkova, IBMP, Russia S. Kaminskaya, IBMP, Russia INTERNATIONAL ORGANIZING COMMITTEE A. Smoleievskiy, IBMP, Russia O. Sorokin, IBMP, Russia M. Polyakov, IBMP, Russia T. Zhuravleva, IBMP, Russia A. Boyko, IBMP, Russia I. Zubov, IBMP, Russia S. Fedyay, IBMP, Russia O. Ivanov, IBMP, Russia K. Vlasova, IBMP, Russia R. Zaripov, IBMP, Russia

Chairperson O. Orlov, RAS/IBMP, Russia 6 7

PROGRAM COMMITTE LOCATION MAP

Chairperson E. Fomina, IAA/ IBMP, Russia

Members: L. Buravkova, IBMP, Russia D. Anikeev, IBMP, Russia P. Norsk, NASA, USA V. Sychev, IBMP, Russia G. Clement, NASA, USA Yu. Bubeev, IBMP, Russia M. Downs, NASA, USA A. Suvorov, IBMP, Russia E. Feichtinger, IAF, France V. Gushin, IBMP, Russia P. Rettberg, IAA/DLR, Germany A. Shtemberg, IBMP, Russia Ch. Rogon, DLR, Germany B. Shenkman, IBMP, Russia A. Chouker, LMU, Germany V. Ilyin, IBMP, Russia S. Schneider, GSU, Germany E. Ilyin, IBMP, Russia A. Pavy-Le Traon, CHU Toulouse & MEDES, France I. Larina, IBMP, Russia Ph. Arbeille, UMPS-CERCOM, France L. Moukhamedieva, IBMP, Russia A. Maillet, MEDES, France M. Belakovskiy, IBMP, Russia S. Iwase, Aichi Medical University, Japan N. Artuhina, MMC, Russia A. Al Rais, MBRSC, UAE E. Tomilovskaya, IBMP, Russia L. Yinghui, ACC, China V. Rusanov, IBMP, Russia Representative of the Ministry of Science and Higher J. Popova, IBMP, Russia Education, Russia TBD Venue — Square of Europe 2, Moscow 121059, T. Tishchenko, Roscosmos, Russia Radisson Slavyanskaya Hotel & Business Centre M. Kharlamov, GCTC, Russia Е. Luchitskaya, IBMP, Russia V. Bogomolov, IBMP, Russia A. Kussmaul, IBMP, Russia 8 9

HOW TO GET TO RADISSON SLAVYANSKAYA CONGRESS CENTER MAP THE RADISSON SLAVYANSKAYA HOTEL & BUSINESS CENTRE, MOSCOW

2, Square of Europe, Moscow, 121059, Russia The hotel is located in the heart of Moscow, just a few minutes from historical attractions such as the Kremlin and Red Square. The Radisson Blu Slavyanskaya Hotel & Business Center is located close to public transport, making it easy to get around the city. The convenient Moscow Route Planner service will help you to build the best route around Moscow — by metro, bus and other types of transport. Electric train Near the hotel there is the Kievsky train Station, which provides convenient access to airports and to other stations in Moscow and the region. Metro Metro is a fast, convenient and practical mode of transport that allows you to avoid traffi c jams. Many stations of Moscow Metro, decorated with mosaic panels and sculptural compositions — are real works of art. Kievskaya Metro Station, which is located next to the hotel, opposite Kievsky Train Station, is an excellent starting point for a city tour. Bus, trolleybus and tram Almost any place in the city can be reached by bus, trolleybus or tram. Bus stops are marked with yellow signs with the letter “A”, trolleybus stops are marked with the letter “T”, and tram stops are marked with the letters “Tr”. ✈From Vnukovo International Airport By train: Take the Aeroexpress train and get off at Kievsky Train Station, then walk 650 m to the hotel. By car: The hotel is about 30 km away. Drive along 2nd Reisovaya Street, then turn right onto Kievskoe Shosse (Highway). Turn left on Kosygina Street, which leads directly to the hotel. ✈From Sheremetyevo International Airport By public transport: Go to the stop “Hotel”, take the bus 851 and get off at the stop “Station “Belomorskaya””. Take the train number 2, get off at the station “Belorusskaya”, get to the train number 5 and go to the “Kievskaya”. Walk 750 m to the hotel. By car: The hotel is about 36 km away. Go over the bridge to the Leningradskoe Shosse (Highway), go straight along the highway, then turn onto Begovaya Street. Go straight to Krasnopresnenskaya Embankment, turn left and, moving along the embankment, turn left on the second bridge. The hotel is on the left. ✈From Moscow Domodedovo Airport By public transport: Take the bus 308e, get off at the stop “Station “ Domodedovo””, go to the metro station “Domodedovo” and take the train number 2 to Paveletskaya. Go to the train number 5 and take it to the station “Kievskaya”, which is located 750 m from the hotel. By car: The distance to the hotel is about 50 km. Go straight to the Kashirskoye Shosse (Highway), then turn left on the MKAD (Moscow Ring Road) and go to Leninsky Prospekt. Turn onto Kosygina Street, which leads directly to the hotel. 🚆From Kievskaya station By foot: The distance from the metro station to the hotel is only 650 m. 10 11

GENERAL INFORMATION SCHEDULE

EVENT PARTICIPATION: April 5, Monday The event is held in a mixed (gibrid) format. On the venue of the Radisson Slavyanskaya Hotel (Moscow, Europe Square, 2) and online. Online access is provided through the participant’s Personal Account on the event website 08.00-09.00 Registration and Connecting participants, Technical Information https://his2021-moscow.org/ Hall Conference-Hall

Openning Ceremony BROADCASTING: The entrance to the broadcast is carried out through the participant’s personal account on 09.00-11.30 the event website. To create a Personal Account, you have to register. Also for getting access to the Summit (Greetings from Offi cials, Welcome from ISS and Baykonur, Concert) you need to register with Zoom. For a more convenient transition to broadcasts, we recommend installing the Chairs: O. Orlov Zoom application on your computer in advance from this link https://zoom.us/ download. It is important to log into Zoom using the same e-mail that you registered on the event site. 11.30-12.30 Plenary session PRESENTATION ONLINE: For the presentation you will be sent a separate link to connect as a member of the Speakers: P. Vlasov, M. Kharlamov, O.I. Orlov group. Test connections for the speakers are made before the event. We ask you to connect to the beginning of 12.30-14.00 Welcome Reception the session where you have your talk. The speaker launches the presentation and controls the time of speaking. Hall Conference-Hall PRESENTATION FROM THE EVENT VENUE: If you are making your talk from the event venue, you need to register and upload your presentation at the Presentation desk. It will be redirected to the room where you are making 14.00-15.20 Plenary session your talk. Speakers: V.A. Soloviev, A. Van Ombergen, C. Rogon, L. Suchet

SPEAKERS’ PRESENTATIONS 15.20-15.40 Break Please provide your presentation on a USB memory card (“fl ash drive”) to the technical specialist at the reception Hall Conference-Hall (Presentation desk). Together with a technical specialist, you can check how your presentation opens and how 15.40-16.40 Plenary session the data is refl ected. All presentations on the network will be transmitted to the performance hall. You do not need your laptop and fl ash card in the hall, because this may violate the rules of the session and require the Speakers: S. Platts, Ch. Feichtinger, W. Tianyi restoration and additional confi guration of the equipment. Hall Conference-Hall

ATTENTION and Mars Exploration 16.40-17.50 Round Table When you create a fi le in the Power Point program, when preparing your presentation, please make sure that O.I. Orlov, L.M. Zeleniy, S.K. Krikalev, O.V. Kotov, A.P. Grishin all graphs are included in the presentation fi le. The fonts must be standard, such as Times New Roman, Arial, or Courier. If you want to use non-standard fonts, they must be included in the presentation fi le. Please also set Moderator E. Fomina the slide size to 16x9. 17.50-18.30 Transfer to boat 18.30-21.30 Lunch VIDEO RECORDINGS OF THE EVENT: Reports were recorded before the event. Recordings of the reports, as agreed by the speakers, will be posted in their Personal Accounts, so that participants can get acquainted with them in advance. April 6, Tuesday The program also includes Short Talks performances. Video recordings of these performances will also be posted in Personal Accounts and launched during breaks in the halls on the relevant topics for review. 08.00-09.00 Registration and Connecting participants, Technical Information Hall Mussorgsky After the event, all records will be available in your Personal Accounts for a month. 09.00-10.00 Plenary session Hall Mussorgsky CERTIFICATES OF PARTICIPATION: Participants’ certifi cates will be uploaded in participants’ Personal Accounts not later than 20 days after the event. Moon and Interplanetary missions. Vision of cosmonauts and 10.00-10.40 Round Table S.K. Krikalev, А.А. Misurkin, А.А. Ivanishin CONTACTS: Technical partner of the event — Trialogue Ltd. tel.: +7 (499) 390-34-38, +7 (926) 848-23-58 Moderator: e-mail: [email protected] 10.40-11.00 Coff ee Break, Short Talks Event website: https://his2021-moscow.org/ 12 13

April 6, Tuesday April 6, Tuesday Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov Proteomics, Transcriptomics and Genomics in Space — New approaches and concepts for SANS/VIIP risk Infl uence of hypomagnetic 11.00-13.00 Neuroscience problems in Deep Space Missions 11.00-13.00 11.00-13.00 11.00-13.00 Personalized Medicine prevention conditions in long-term space fl ights OMICS S. Robin Elgart/ A. Shtemberg C. Stern/ O.Man`ko O. Orlov / Yu.Bubeev Ch.H. Borchers / L. Buravkova Chairs: Chairs: Chairs: Chairs: R-r A. Kussmaul R-r A. Smoleevskiy R-r O. Popova/M. Onuchina R-r D. Kashirina 13.00-14.00 Break, Short Talks 13.00-14.00 Break, Short Talks Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov Neurophysiology and psyсhophysiology Radiation during deep space exploration: 14.00-15.30 14.00-15.30 , Space Biology and Space Biotechnology 14.00-15.30 14.00-15.30 Multidisciplinary Studies related with Humans in Space of operator activity risk estimation and countermeasure Ch.Kourtidou Papadeli/ S. Schneider/ O. Ryumin P. Rettberg/ V. Sychev D. Goukassian/ V. Shurshakov H.-C. Gunga/ A. Maillet Chairs: Chairs: Chairs: Chairs: R-r A. Smoleevskiy R-r D. Komissarova R-r A. Savinkina R-r A. Kussmaul 15.30-16.30 Discussion 15.30-16.30 Discussion 15.30-16.30 Discussion 15.30-16.30 Discussion 16.30-17.00 Coff ee Break, Short Talks 16.30-17.00 Coff ee Break, Short Talks Hall Mussorgsky Hall Mussorgsky 17.00-18.00 Plenary session 17.00-18.00 Plenary session Speakers: L. Abadie, M. Stenger, F.A. Cucinotta Speakers: L. Abadie, M. Stenger, F.A. Cucinotta 18:00-18:20 Discussion 18:00-18:20 Discussion

April 7, Wednesday April 7, Wednesday 08.00-09.00 Registration and Connecting participants, Technical Information 08.00-09.00 Registration and Connecting participants, Technical Information Hall Mussorgsky Hall Mussorgsky 09.00-10.00 Plenary session 09.00-10.00 Plenary session Speakers: N. Kanas, E.A. Ilyin, L. Vico, V. Novikov, G. Vassilieva Speakers: N. Kanas, E.A. Ilyin, L. Vico, V. Novikov, G. Vassilieva Hall Mussorgsky Hall Mussorgsky Women in Space Women in Space 10.00-10.40 Round Table 10.00-10.40 Round Table A. Yu. Kikina, E.S. Luchitskaya, L. O’Hara, G. Wilt A. Yu. Kikina, E.S. Luchitskaya, L. O’Hara, G. Wilt Moderator: A. Stepanova Moderator: A. Stepanova 10.40-11.00 Break, Short Talks 10.40-11.00 Break, Short Talks Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov SIRIUS project. Psychological aspects of isolation and Studies of sensory-motor system functions in Dry Changes in Cardiovascular and Pulmonary Systems as a 11.00-13.00 11.00-13.00 11.00-13.00 11.00-13.00 Medical Support in the Autonomous Flight confi nement Immersion and Bedrest experiments Risk of Interplanetary Missions B. Vessey/V. Gushin/C. Taff orin Dr. Jenkin/E. Tomilovskaya J. Jordan/U. Hoff mann O. Kotov/V. Bogomolov Chairs: Chairs: Chairs: Chairs: R-r A. Savinkina R-r A. Saveko R-r A. Salnikov R-r Yu. Smirnov 13.00-14.00 Break, Short Talks 13.00-14.00 Break, Short Talks Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov SIRIUS project. Physiological aspects of isolation and Eff ects of gound-based models of microgravity Skeletal Unloading and Other Aspects of Bone Study Under Space Psychology and Human Factors in Interplanetary 14.00-15.30 14.00-15.30 14.00-15.30 14.00-15.30 confi nement. on cardio-vascular, central nervous and other systems the Action of Spacefl ight Factors Missions M. Maggioni/ V.Abeln/V.Ilyin L. Vico/ G. Vassilieva N. Kanas/ V. Gushin Chairs: Chairs: E. Tomilovskaya Chairs: Chairs: R-r — Yu. Popova R-r Т. Agaptseva R-r A. Savinkina R-r — E. Luchitskaya 15.25-16.30 Discussion 15.30-16.30 Discussion 15.30-16.30 Discussion 15.20-16.30 Discussion 16.30-17.00 Coff ee Break, Short Talks 16.30-17.00 Coff ee Break, Short Talks 14 15

April 7, Wednesday April 7, Wednesday Hall Mussorgsky Hall Mussorgsky 17.00-18.00 Plenary session 17.00-18.00 Plenary session Speakers: K. Lehnhardt, A. Whitmire, M. Shelhamer Speakers: K. Lehnhardt, A. Whitmire, M. Shelhamer 18:00-18:20 Discussion 18:00-18:20 Discussion

April 8, Thursday April 8, Thursday 08.00-09.00 Registration and Connecting participants, Technical Information 08.00-09.00 Registration and Connecting participants, Technical Information Hall Mussorgsky Hall Mussorgsky 09.00-10.00 Plenary session 09.00-10.00 Plenary session Speakers: V.K. Ilyin, A. Stahn, F.L. Wuyts Speakers: V.K. Ilyin, A. Stahn, F.L. Wuyts Hall Mussorgsky Hall Mussorgsky Young scientists Young scientists 10.00-10.40 Round Table 10.00-10.40 Round Table D.A. Shishkin, D. Kobets, Yu.I. Smirnov D.A. Shishkin, D. Kobets, Yu.I. Smirnov Moderator: A. Stepanova Moderator: A. Stepanova 10.40-11.00 Coff ee Break, Short Talks 10.40-11.00 Coff ee Break, Short Talks Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov Skeletal Muscle Under Conditions 11.00-12.20 Commercial Spacefl ight Exercise and Countermeasures in the Interplanetary Habitability, Nutrition and Life Support in Space 11.00-13.00 11.00-13.00 Of Real And Simulated Microgravity 11.00-13.00 Chairs: V.S. Zander/ I. Saenko / R-r A. Savinkina Missions, Countermeasure Evaluation Part 1 Exploration 12.20-13.00 Chairs: S. Schneider/ E. Fomina / R-r — S. Smoleevskiy Chairs: J. Rittweger/ B. Shenkman / R-r S. Tyganov Chairs: K. Beblo-Vranesevic /V. Ilyin / R-r K. Shef Chairs: A. Kuritsyn, A. Kumar / R-r — N. Chub 13.00-14.00 Break, Short Talks 13.00-14.00 Break, Short Talks Place Museum of Cosmonautics Place Museum of Cosmonautics 15.00-17.00 60th Anniversary of the First Human Space Flight 15.00-17.00 60th Anniversary of the First Human Space Flight Chairs: R. Pischel, N. Artyukhina, M. Belakovskiy, R-r — A. Kussmaul Chairs: R. Pischel, N. Artyukhina, M. Belakovskiy, R-r — A. Kussmaul 16.15-17.00 Tour 16.15-17.00 Tour Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov The Problems of Muscle Immunology Artifi cial Intelligence, VR, Telemedicine in Interplanetary 14.00-15.20 Education and Outreach in Space Sciences 14.00-15.30 14.00-15.10 14.00-15.30 Part 2 and Biochemistry for Personalized Missions and on the Earth Chairs: Ch.Rogon/ L. Buravkova / R-r D. Kashirina Chairs: C. Reggiani/ B. Shenkman / R-r S. Tyganov Chairs: A. Chouker/ S. Ponomarev / R-r A. Pakhomova Chairs: A. Stahn/A. Smoleevskiy / R-r D. Shved 15.20-16.30 Discussion 15.30-16.30 Discussion 15.10-16.30 Discussion 15.30-16.30 Discussion 16.30-17.00 Coff ee Break, Short Talks 16.30-17.00 Coff ee Break, Short Talks Hall Mussorgsky Hall Mussorgsky 17.00-18.00 Plenary session 17.00-18.00 Plenary session Speakers: E.V. Fomina, G. Clement, M. Downs Speakers: E.V. Fomina, G. Clement, M. Downs 18:00-18:20 Discussion 18:00-18:20 Discussion 18.20-18.50 Closing Remarks 18.20-18.50 Closing Remarks April 9, Friday — Business Day April 9, Friday — Business Day 10.00-13.00 18th DLR/IBMP Life Sciences Working Group Meeting (Restricted access) 10.00-13.00 18th DLR/IBMP Life Sciences Working Group Meeting (Restricted access) Chairs: O.I. Orlov/M. Braun Chairs: O.I. Orlov/M. Braun 13.30-14.30 Seminar on the problems of eff ects of social isolation (Open access) 13.30-14.30 Seminar on the problems of eff ects of social isolation (Open access) Chairs: V. Gushin Chairs: V. Gushin 15.30-20.30 NASA/IBMP Joint Working Group Meeting (Restricted access) 15.30-20.30 NASA/IBMP Joint Working Group Meeting (Restricted access) Chairs: O.I. Orlov/C. Kundrot Chairs: O.I. Orlov/C. Kundrot

The technical part of the Business Day is supported by the Ministry of Science and Higher Education of the Russian Federation in the frame of the project “Pavlov Center for Integrative Physiology to Medicine, High-tech Healthcare and Stress Tolerance Technologies”. 16 17

PROGRAM

April 5, Monday April 6, Tuesday 08.00-09.00 Registration and Connecting participants, Technical Information 08.00-09.00 Registration and Connecting participants, Technical Information Hall Conference-Hall Hall Mussorgsky Openning Ceremony 09.00-11.30 (Greetings from Offi cials, Welcome from ISS and Baykonur, concert) 09.00-10.00 Plenary session Hall Conference-Hall The Investigation Of Combined Impact Of Ionizing Radiation And Hypogravity On Central Nervous System As A Key Problem Of Deep 11.30-12.30 Plenary session 09.00-09.20 Space Missions Safety A.S. Shtemberg Preparation for the fi rst human space fl ight (for the 60th anniversary of the fl ight of Yu.A. Gagarin) 11.30-11.50 P. Vlasov, M. Kharlamov Radiobiology of the visual system 09.20-09.40 M. Ostrovsky Space medicine from Gagarin to nowadays 11.50-12.10 O.I. Orlov Neuroradiobiology Issues and Radiation Risk in Deep Space Flights 09.40-10.00 12.10-12.30 Documentary fi lm about the training to fi rst human fl ight E.A. Krasavin 12.30-14.00 Welcome Reception Hall Mussorgsky Hall Conference-Hall Moon and Interplanetary missions. Vision of cosmonauts and astronauts 14.00-15.20 Plenary session Round Table 10.00-10.40 Sergey Konstantinovich Krikalev — Cosmonaut, Executive Director of Human Space Program Russian manned program. State and prospects 14.00-14.20 V.A. Soloviev Alexander Alexandrovich Misurkin — Сosmonaut of the Gagarin Research Institute and test cosmonaut training center Anatoly Alekseevich Ivanishin — Сosmonaut of the Gagarin Research Institute and test cosmonaut training center The ’s Human Research activities: past, present and future 14.20-14.40 A. Van Ombergen Moderator: A. Stepanova Decades of fruitful Russian German cooperation in Space Life Sciences 14.40-15.00 10.40-11.00 Coff ee Break, Short Talks C. Rogon, K. Stang, M. Girgenrath, M. Braun, P. Graef Half century of scientifi c and technical collaborations between France and Russia for bilateral Manned Space Flights 15.00-15.20 L. Suchet 15.20-15.40 Break Hall Conference-Hall 15.40-16.00 Plenary session The NASA Human Research Program: Overcoming the Challenges of Exploration Spacefl ight 15.40-16.00 S. Platts, J. McPhee IAF celebrating the 60th Anniversary of Human Spacefl ight Era 16.00-16.20 Ch. Feichtinger The Peaceful Use of Space 16.20-16.40 W. Tianyi 16.40-17.00 Discussion Hall Conference-Hall Moon and Mars Exploration Round Table Oleg Igorevich Orlov — Academician of the RAS, Director of Institute of Biomedical Problems 17.00-17.50 Lev Matveevich Zeleniy — Academician of the RAS, Scientifi c Director of the Space Research Institute of the Russian Academy of Sciences Sergey Konstantinovich Krikalev — Cosmonaut, Executive Director of Human Space Program Oleg Valerievich Kotov — Cosmonaut, PHD, Deputy Head of Science of IBMP of the Russian Academy of Sciences Aleksei Petrovich Grishin — Head of the Department of Medical Administration of the Cosmonaut Training Center Moderator: A. Stepanova 18.00-18.30 Transfer to boat 18.30-21.30 Lunch 18 19

April 6, Tuesday April 6, Tuesday Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov Proteomics, Transcriptomics New approaches and concepts for SANS/VIIP risk Infl uence of hypomagnetic conditions in long-term 11.00-13.00 Neuroscience problems in Deep Space Missions 11.00-13.00 11.00-13.00 11.00-13.00 and Genomics in Space — Personalized Medicine prevention space fl ights OMICS S. Robin Elgart/ A. Shtemberg C. Stern/ O.Man`ko O. Orlov / Yu.Bubeev Ch.H. Borchers / L. Buravkova Chairs: Chairs: Chairs: Chairs: R-r A. Kussmaul R-r A. Smoleevskiy R-r O. Popova/M. Onuchina R-r D. Kashirina Spacefl ight-Associated Changes Space fl ights associated changes in astronauts in the Perivascular Spaces of Astronauts plasma eexosomes derived rna: biomarker G. Barisano, F. Sepehrband, E. Tomilovskaya, Experiment to study the impact of hypomagnetic Space Radiation and Central Nervous System Impacts: identifi cation I. Rukavishnikov, I. Nosikova, L. Litvinova, A. Rumshiskaya, fi elds on the organism of a person «ARFA-19» 11.00-11.15 NASA Standards and Evidence 11.00-11.15 11.00-11.15 11.00-11.15 D.A. Goukassian, M. Truongcao, P. Dubey, C. Gonzalez, V. Petrovichev, V. Sinitsyn, E. Pechenkova, S. Laureys, V.Yu. Kukanov, M.R. Onuchina, S.R. Elgart A. Bajpai, Z. Cheng, M.K. Khlgatian, A. Arakelyan, J. Sijbers, B. Jeurissen, S. Sunaert, P. Parizel, S. Jillings, A.L.Vasin, O.I. Orlov P. Mills, K. Walsh, S. Addya, A. Evans, M. Coleman, H. R. Collins, M. Law, A. Grishin, D. Roberts, A. Brojakowska , K. Fish, R. Kishore, V.N.S. Garikipati Floris L. Wuyts Eff ects of cranial proton irradiation on visuomotor Optic Nerve Head Stady In Space Flight Changes in the profi le of proteins associated with Arfa-19 experiment: simulation behaviour in nonhuman primates I.A. Makarov, I.V. Alferova, the functions of the cardiovascular system in space 11.15-11.30 11.15-11.30 11.15-11.30 of the magnetic fi eld under exposure conditions 11.15-11.30 L.V. Tereshchenko, I.D. Shamsiev, I.V. Bondar, E.A. Krasavin, V.V. Bogomolov, Yu.I. Voronkov, and ground-based model experiments M.R. Onuchina, A.L. Vasin A.V. Latanov V.V. Krivolapov, E.G. Khorosheva V.B. Rusanov, L.Kh. Pastushkova, A.M. Nosovsky, I.M. Larina The infl uence of 8-hour’s compensation Transcriptomic signatures and upstream Long-term cns eff ects of low-dose galactic cosmic The functional state of the Earth’s magnetic fi eld on the autonomic regulation in human skeletal muscle induced by radiation on wildtype and alzheimer’s-like mice of the optic nerve after a long-term 11.30-11.45 11.30-11.45 11.30-11.45 regulation of the heart 11.30-11.45 inactivity and aerobic exercise: a meta-analysis M.K. Schroeder, B.R. Price, space fl ight E.Yu. Bersenev, A.L. Vasin, D. V. Popov, P. A. Makhnovskii, K.A. Khan, B.J. Caldarone, C.A. Lemere S.N. Danilichev, O.M. Manko V.Yu. Kukanov, O.I. Orlov R. O. Bokov, F.A. Kolpakov, O. L. Vinogradova Changes in the blood proteome of cosmonauts Eye examinations in bed rest studies Individual characteristics of central nervous system Infl uence of reduced magnetic fi eld with external signs of microvascular injury to maintain ocular health and to defi ne as an important factor of radioresistance on human central hemodynamics at the fi rst day after landing 11.45-12.00 11.45-12.00 successful application of countermeasures 11.45-12.00 11.45-12.00 A.A. Perevezentsev, A.G. Belyaeva , O.V. Popova, Е.S. Luchitskaya, I.N. Goncharov, L.Kh. Pastushkova, M.I. Koloteva, A.G. C. Stern, D. Mittelstaedt, S. Stupp, K. Klink, K.B. Lebedeva-Georgievskaya, A.S. Shtemberg V.Y. Kukanov, V.B. Rusanov Goncharova, T.M. Glebova, D.N. Kashirina, M. Pittius, S. Ritter, A. Händel K.S. Kireev, I.M. Larina Neuroplasticity and Microgravity: Gene Expression The Impact of Deep Space Radiation on Cognitive Functional condition of the visual Profi le Changes in the Medial Vestibular Nuclei and Performance: From Biological Sex to Biomarkers to system under the condition of one-year wintering Parasympathetic regulation of hemodynamics in the Inferior Olive Nuclei of the Brain of Mice after a 12.00-12.15 Countermeasures 12.00-12.15 at the antacrtic station VOSTOK 12.00-12.15 healthy men under hypomagnetic conditions A.V. 12.00-12.10 30-Day Space Flight on the Bion-M Satellite S. Rosi, K.Krukowski, K. Grue, K. Rieneker, N.Yu. Osetsky, O.M. Manko , Demin, A.V. Suvorov P. Fortygina, P. Kolosov, A. Beletskyi, A.R Ferguson, G. Nelson E.A. Ilyin, O.I. Orlov M. Roshchin, P. Khaitovich, P. Balaban Dynamics Of The Functional Activity Of The Retina The eff ect of physical activity on blood plasma The Novel Extraplanetary Radiation Countermeasures After Four Months Of Isolation In A Sealed Object Gas Exchange and Ventilation in Healthy Humans proteome in 21 day head-down bed rest 12.15-12.30 Initiative (NERCI) 12.15-12.30 Simulated A Space Flight 12.15-12.30 during 8-h Hypomagnetic Exposure 12.10-12.20 D.N. Kashirina, A.G. Brzhozovskiy, L.Kh. Pastushkova, B. J. Sishc, J. Saha, J. Zawaski, R. Elgart M.V. Zueva, V.V. Neroev, I.V. Tsapenko, Yu.A. Bubeev, O.M. J.A. Popova, A.V. Suvorov A.G. Goncharova, A.S. Kononikhin, E.N. Nikolaev, Ch.H. Manko, A.E. Smoleevskiy, A.M. Aleskerov Borchers, I.M. Larina

Molecularbiomarkersof susceptibility forlate-onset The susceptibility of volunteer’s T cells to neuropathologies and multivariate modeling of Assessment Of Visual Functions During A 4-Month Human pain threshold immunomodulation during long-term dry individual risks for operation-relevant behavioral 12.30-12.45 12.30-12.45 Isolation In The SIRIUS-19 Project Manko O.M., Gracheva 12.30-12.45 in hypomagnetic environment 12.20-12.30 immersion defi cits after exposure to space radiation M.A., Rozhkova G.I., Smoleevskiy A.E., Vasilyeva N.N. A.V. Polyakov, A.R. Niyazov, S.O. Fedyay A. Gornostaeva, A. Ratushnyy, A.J. Wyrobek, B.M. Rabin, R.A. Britten, A.M. Mora,R.B. L. Buravkova Gunier,H.E.Witkowska,M. Albertolle, T. Straume 20 21

April 6, Tuesday April 6, Tuesday Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov Stress caused by psychological and physiological Brain stem cells, new neurons, and radiation 12.45-13.00 stress signifi cantly changes the concentration of G. Enikolopov 12.30-12.45 circulating DNA in human blood plasma Morphometric Status Of The Human Retina As A Dynamics of human neurophysiological P.E. Umriukhin, E.S. Ershova, S.A. Ponomarev, Biomarker Of Adaptive Plasticity And Dysfunctions characteristics under the infl uence of a hypomagnetic 12.45-13.00 12.45-13.00 N.N. Veiko, S.V. Kostyuk Irradiation eff ects on the cognitive trait expression Of The Central Nervous System In Chronic Stress environment The method for direct mass spectrometric analysis and neurogenesis in laboratory mice D.A. Podyanov, O.M. Manko, M.V. Zueva, A.M. Aleskerov D.V. Schastlivtseva, Yu.A. Bubeev, T.I. Kotrovskaya 13.00-13.10 of biological samples using porous samplers of diff erent genotypes 12.45-13.00 I.I. Poletaeva, N.A. Ogienko, O.V. Perepelkina, A.V. Revishchin I.A. Popov, S.I. Pekov, M.A. Shamraeva, D.S. Bormotov, R.E. Levin, I.M. Larina, E.N. Nikolaev 13.00-14.00 Break, Short Talks 13.00-14.00 Break, Short Talks Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov Neurophysiology and psyсhophysiology of operator Astrobiology, Space Biology and Space Radiation during deep space exploration: risk Multidisciplinary Studies related 14.00-15.30 14.00-15.30 14.00-15.30 14.00-15.30 activity Biotechnology estimation and countermeasure with Humans in Space Ch.Kourtidou Papadeli/ S. Schneider/ O. Ryumin P. Rettberg/ V. Sychev D. Goukassian/ V. Shurshakov H.-C. Gunga/ A. Maillet Chairs: Chairs: Chairs: Chairs: R-r A. Smoleevskiy R-r D. Komissarova R-r A. Savinkina R-r A. Kussmaul ISS — the prediction platform for exploration Reduced Glial Scarring Through Hypergravity Exposure of microorganisms in outer space missions EVA performance 14.00-14.10 Exposure 14.00-14.10 E.A. Deshevaia, S.V. Fialkina, A.A. Guridov, V.A. 14.00-14.10 М.M. Kharlamov, B.I. Kryuchkov, V.M. Usov, T.B. Kukoba, Ya. Lichterfeld Shcherbakova, E.V. Shubralova, O.S. Tsygankov, V.K. Ilyin Y.A. Bubeev, E.V. Fomina Radiation Risk in Lunar Missions: Estimation and Cerebral activation to imagination of spatial Countermeasures 14.00-14.15 navigation is altered after 6 months in microgravity V.A. Shurshakov, A.V. Shafi rkin, O.A. Ivanova, K.O. J. Annen, E. Tomilovskaya, S. Larroque, S. Jillings, Resistance mechanisms of Bacillus subtilis-20 and Inozemtsev, A.E. Lishnevskii, R.V. Tolochek Infl uence of a female gender on the effi ciency 14.10-14.20 E. Pechenkova, A. Rumshiskaya, L. Litvinova, I. Nosikova, 14.10-14.20 Bacillus licheniformis-24 strains 14.10-14.20 of work in a crew of manned spacecraft I. Rukavishnikov, A. Van Ombergen, S. Sunaert, P.M. Parizel, P.J. Osipova, S.V. Poddubko, D.S. Karpov A.Yu. Kikina V. Sinitsyn, V. Petrovichev, P. zu Eulenburg, B. Jeurissen, J. Sijbers, A. Demertzi, S. Laureys, F.L. Wuyts Sustainable and Reversible eff ects of spacefl ight on human brain function and connectivity Astrobiological aspect of the resistance of fungal The results of biomedical research on board of the S. Jillings, E. Pechenkova , E. Tomilovskaya , A. Rumshiskaya, communities from desert soils to the impact of the Radiation Dose Assessment Throughout The Solar ISS and on Earth — a contribution to the medical 14.20-14.30 L. Litvinova, I. Nosikova, I. Rukavishnikov, A. Van Ombergen , 14.20-14.30 simulated Martian conditions 14.15-14.30 System 14.20-14.30 support of orbital and autonomous fl ights S. Sunaert, P.M. Parizel, V. Sinitsyn, V. Petrovichev, M.O. KrIuchkova, E.A. Vorobyova, A.E. Ivanova, V.S. M.I. Dobynde, V.A. Shurshakov , J. Guo, S.I. Svertilov, O. Ploc A.R. Kussmaul, M.S. Belakovskiy, A.B. Sakharova P. zu Eulenburg, B. Jeurissen, J. Sijbers, J. Annen, S. Laureys, Cheptsov, A.K. Pavlov A. Demertzi , F.L. Wuyts Pharmacological induction of hypobiosis: trends Eff ects of short-term isolation and chronic sleep and prospects. Part I. Reversible torpor and Feasibility Study of Habitat Design Commonalities Ground laboratory studies of radiation eff ect of space deprivation on cognitive performance hypothermia for Mars Transit and Surface Missions 14.30-14.40 14.30-14.40 14.30-14.45 rays in interplanetary space 14.30-14.40 K. Brauns, A. Friedl-Werner, N.M. Zakharova, Y.S. Tarahovsky, I.S. Fadeeva, O. Bannova, V.M. Skorkin H.C. Gunga, A.C. Stahn N.P. Komelina, M.O. Khrenov, O.V. Glushkova, S. Haeuplik-Meusburger D.A. Prokhorov, V.P. Kutyshenko, A.L. Kovtun

Brain Changes in Response to a Combined Exercise Pharmacological induction of hypobiosis: trends Evaluation of Ionizing Radiation Eff ects and An approach to defi ne requirements and evaluation and Sensory Stimulation Countermeasure During and prospects. Part II. Long-term pharmacological Mitigation Techniques for Infl atable Space Habitats philospohy for crew comfort in short duration Long-Duration Antarctic Missions torpor with feedback-controlled drug 14.40-14.50 14.40-14.50 14.45-15.00 in Deep Space Missions 14.40-14.50 human spacefl ight mission A.C. Stahn, D.F. Dinges , D. Roalf, administration S. Anantaram, A. Varma, P.M. Ravishankar, P.A. Ravishankar, A. Kibe, R.C. Gur, A. Friedl-Werner, K. Brauns, S. Mendt, Y.S. Tarahovsky, N.P. Komelina, I.S. Fadeeva , K.G. Vinod, P. Sankaravelayutham S. Vishnu, K. G. Vinod, P. Sankaravelayutham H.C. Gunga, S. Kühn , A. Chouker, M. Basner A.L. Kovtun, N.M. Zakharova 22 23

April 6, Tuesday April 6, Tuesday Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov Neurophysiological mechanisms of cognitive Human-systems integration needs analysis The motility of spermatozoa of mice and Drosophila processes when performing operator tasks of for on-board anomaly resolution during earth melanogaster changes diff erently under modelling 14.50-15.00 diff erent complexity 14.50-15.00 14.50-15.00 independent operations microgravity conditions D.V. Schastlivtseva, T.I. Kotrovskaya, T. Panontin, M. Parisi, K. McTigue, I.V. Ogneva B. Johannes, Yu.A. Bubeev Shu-chieh Wu, A. Vera Radi-N2 and Matroshka-R: Cell respiration of spermatozoa of the fruit Measurements of Neutron Radiationon the fl y Drosophila melanogaster under simulated International Space Station 15.00-15.05 microgravity 15.00-15.15 (2009 — 2020) A.А. Sukonkina, M.A. Usik, M.B. Smith, H.R. Andrews, H. Ing, E.M. Johnston, GAUSS Precursor The eff ects of sleep disturbances on working memory N.S. Biryukov, Yu.S. Zhdankina, I.V. Ogneva S. Khulapko, M.R. Koslowsky,R. Machrafi , Mission for Mars Exploration 15.00-15.10 are mediated by changes in melatonin level 15.00-15.10 I. Nikolaev, V. Shurshakov, L. Tomi R. Di Roberto, S. Carletta, Yu.V. Ukraintseva, K.M. Liaukovich, M.O. Shilov Transient increase in the rate of cell respiration of mouse spermatozoa under exposure to simulated N. Sparvieri, F. Graziani 15.05-15.10 hypergravity M.A. Usik, Yu.S. Zhdankina, N.S. Biryukov, A.A. Sukonkina, I.V. Ogneva Fighting microbial biofi lms in space by ESA’s upcoming space microbiology and material science Psychological and psychophysiological chronic stress «Plasma — biological object» interaction: experiment BIOFILMS 15.10-15.20 predictors 15.10-15.20 15.10-15.20 study of basic mechanisms K. Siems , D. Müller , L. Maertens, R. Van Houdt , A.A. Avdeichik, O.M. Manko, Y.A. Bubeev, E.V. Kostenko A.K. Martusevich, A.G. Galka, E.S. Golygina R. L. Mancinelli , N. Caplin , J. Krause , R. Demets , A. Tortora , M. Laue , F. Mücklich , C. E. Hellweg, R. Möller Microgravity induced resting-state networks’ and The microbiome of the International Lifetime risk of tumor development metabolic alterations during sleep onset Space Station (ISS) in c57b1/6j mice exposed to a single Ch.A. Frantzidis, I. Machairas, S. Gylou, Ch.M. Nday, P. Rettberg, M. Mora, L. Wink, I. Kögler, A. Mahnert, full body gamma and simGCRsim radiation 15.20-15.30 S.N. Ketseridou, M. Mitsiou, Ch. Giantsios, Ch.S. Plomariti, 15.20-15.30 15.15-15.30 P. Schwendner, R. Demets, C. Cockell, T. Alekhova, A. Brojakowska, M. Bisserier, M.K. Khlgatian, M. Velana, A. Xatzicharistou, A. Karkala, D. Kontaxopoulou, A. Klingl, R. Krause, A. Zolotariof, A. Alexandrova, S. Zhang , V. Gillespie, Y. Dai, L. Hadri, Crystalloscopic test-system E. Stanitsa, S. Fragkiadaki, S.G. Papageorgiou, Ch. Moissl-Eichinger D.A. Goukassian for cold plasma eff ects detection P. Bamidis, Ch. Kourtidou-Papadeli, J. Vernikos 15.20-15.30 A.K. Martusevich, A.G. Galka, Green Moon Project: Encapsulated E.S. Golygina, A.N. Tuzhilkin, A.S. Fedotova and Pressurised Habitat for Plants on the Moon 15.30-15.40 (Habitability and Space Agriculture) 15.30-16.30 Discussion J.M. Ortega-Hernandez, J. Pla-Garcia, J. Martinez-Frias, E. Sanchez-Rodriguez, J. Hernandez-Narvaez 15.30-16.30 Discussion 15.30-16.30 Discussion 15.30-16.30 Discussion 16.30-17.00 Coff ee Break, Short Talks 16.30-17.00 Coff ee Break, Short Talks Hall Mussorgsky Hall Mussorgsky 17.00-18.00 Plenary session 17.00-18.00 Plenary session NASA Artemis Missions & Human Research Opportunities NASA Artemis Missions & Human Research Opportunities 17.00-17.20 17.00-17.20 L. Abadie L. Abadie NASA Update on Spacefl ight Associated Neuro-ocular Syndrome: Recent Findings and Future Plans NASA Update on Spacefl ight Associated Neuro-ocular Syndrome: Recent Findings and Future Plans 17.20-17.40 17.20-17.40 M. Stenger M. Stenger Review of Space Radiation Health Risks for Exploration Missions Review of Space Radiation Health Risks for Exploration Missions 17.40-18.00 17.40-18.00 F.A. Cucinotta F.A. Cucinotta 18.00-18.30 Discussion 18.00-18.30 Discussion 24 25

April 7, Wednesday April 7, Wednesday 08.00-09.00 Registration and Connecting participants, Technical Information 08.00-09.00 Registration and Connecting participants, Technical Information Hall Mussorgsky Hall Mussorgsky 09.00-10.00 Plenary session 09.00-10.00 Plenary session Psychological and Interpersonal Issues in Space: On-Orbit, Mars, and Beyond Psychological and Interpersonal Issues in Space: On-Orbit, Mars, and Beyond 09.00-09.20 09.00-09.20 N. Kanas N. Kanas

Biomedical Research In Antarctica and Human Flights Into Deep Space Biomedical Research In Antarctica and Human Flights Into Deep Space 09.20-09.40 09.20-09.40 E.A. Ilyin E.A. Ilyin

Our skeleton adapts to the conditions of space fl ight but the return to the Earth is challenging Our skeleton adapts to the conditions of space fl ight but the return to the Earth is challenging 09.40-10.00 09.40-10.00 L. Vico, V. Novikov, G. Vassilieva L. Vico, V. Novikov, G. Vassilieva Hall Mussorgsky Hall Mussorgsky Women in Space Women in Space Round Table Round Table Anna Yurievna Kikina — Сosmonaut of the Gagarin Research Institute and test cosmonaut training center Anna Yurievna Kikina — Сosmonaut of the Gagarin Research Institute and test cosmonaut training center 10.00-10.40 10.00-10.40 Elena Sergeevna Luchitskaya — senior researcher of the Institute of biomedical problems Russian Academy of science Elena Sergeevna Luchitskaya — senior researcher of the Institute of biomedical problems Russian Academy of science Loral O’Hara — , Director of NASA Operations in Russia, Loral O’Hara — astronaut, Director of NASA Operations in Russia, Grier Wilt — Deputy Director of NASA Operations in Russia Grier Wilt — Deputy Director of NASA Operations in Russia Moderator: A. Stepanova Moderator: A. Stepanova 10.40-11.00 Coff ee Break, Short Talks 10.40-11.00 Coff ee Break, Short Talks Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov SIRIUS project. Psychological aspects of isolation and Studies of sensory-motor system functions in Dry Changes in Cardiovascular and Pulmonary Systems as a 11.00-13.00 11.00-13.00 11.00-13.00 11.00-13.00 Medical Support in the Autonomous Flight confi nement Immersion and Bedrest experiments Risk of Interplanetary Missions

B. Vessey/V. Gushin/C. Taff orin Dr. Jenkin/E. Tomilovskaya J. Jordan/U. Hoff mann O. Kotov/V. Bogomolov Chairs: Chairs: Chairs: Chairs: R-r A. Savinkina R-r A. Saveko R-r A. Salnikov R-r Yu. Smirnov Human Capabilities Assessments for Autonomous Missions: Features of communication of isolated crew of mixed Approaches to the assessment of cardiovascular Head down bed rest eff ects the perception of upright: A Multi-Team Research Eff ort to Reduce Risk national and gender composition with the control center functionality at the ISS 11.00-11.10 11.00-11.10 perceptual support for bed rest as a microgravity analog 11.00-11.15 11.00-11.15 in the Human-System Integration Architecture D.M. Shved, V.I. Gushin, E. Luchitskaya, I. Funtova, V. Rusanov M. Jenkin, L. R. Harris, R. Herpers for Future Deep-Space Missions A.K. Yusupova, A.O. Savinkina, S.A. Lebedeva S.K. Robinson, B.F. Gore, A.M. Whitmire Self-training of the crew members of the SIRIUS 18/19 Sleep architecture changes during Arterial Stiff ness assessed by estimated Pulse Wave The role of a doctor in a long-distance space fl ight project using the 6df software 21-day dry immersion Velocity is not aff ected during 6 months Spacefl ight 11.10-11.20 11.10-11.20 11.15-11.20 11.15-11.30 O.V. Kotov, M.S. Belakovskiy, D.V. Schastlivtseva, B. Johannes, Yu.V. Ukraintseva, G.V. Kovrov, S.I. Posokhov, E.Yu. Bersenev, K.A. E. Luchitskaya, J-N. Hönemann, I. I. Funtova, A.R. Kussmaul T.I. Kotrovskaya, Yu.A. Bubeev Pikalov, D.V. Kondukova, E.S. Tomilovskaya S. Möstl, H. Reuter, J. Tank, F. Hoff mann

Emotional state dynamics and its assessment with Head-down tilt position, but not the duration of bed rest Spacefl ight duration and the mortality of cosmonauts Features of heart rate variability and myocardium energy 11.20-11.30 subjective and objective methods in SIRIUS-19 experiment 11.20-11.30 aff ects resting state electrocortical activity 11.20-11.30 11.30-11.45 K.V. Betts, I.V. Bukhtiyarov, metabolism in space fl ight Y. D. Yakhya, V. B. Rusanov A.O. Savinkina, P.G. Kuznetsova, D.M. Shved, V I. Guschin K. Brauns, A. Friedl-Werner, H.C. Gunga, A.C. Stahn G.I. Tikhonova, I.B. Ushakov, Yu.I. Voronkov Interpersonal Interactions, Communications And Group Strict head down tilt (HDT) bed rest: Prolonged exposure to chronic intermittent hypoxia: Eff ectiveness Of The SIRIUS-19 Crew From Integrated Biofeedback system for enhanced the improvement of a ground-based microgravity eff ects on cardiac autonomic modulation during sleep 11.30-11.40 Psychological And Ethological Data 11.30-11.40 11.30-11.40 11.45-12.00 motor control under microgravity analogue for sans-related research M.A. Maggioni, H.-C. Gunga, A.G. Vinokhodova, C.Taff orin, P.G. Kuznetsova, A. Savinkina, K. J.C. Johnson, P.A. Johnson, A. Mardon A. Noppe, M. von der Wiesche, N. Klischies, A. Nitsche, E. Mulder N. Hellner, S. Mendt, Lang Tapia M Eskov, V.I. Gushin Structural and functional eff ects of full-body space Emotional relationships as a way to overcome the isolation Phases of adaptation to the conditions of «dry» immersion radiation exposure on the right ventricle and lungs Mental Health in Prolonged Space Travel 11.40-11.50 stress during spacefl ight simulation 11.40-11.50 according to the neurofunctional state of volunteers 11.40-11.50 12.00-12.15 M. Bisserier, M.K. Khlgatian, C. Grano, S. Zhang, J.C. Johnson, P.A. Johnson, A. Mardon A.G. Vinokhodova, I. Solcova, V.I. Gushin, P.G. Kuznetsova M.A. Skedina, A.A. Kovaleva, M.G. Potapov A. Brojakowska, K. Fish, D.A. Goukassian, L. Hadri

Monitoring physical activity, psychological, Impact Of Long-Term Dry Immersion On Signaling Cardiovascular Disease Risk Modeling for Astronauts: On the possibility of using GVS-technology for visual fl ight physiological parameters and independent of Pathways In Human Soleus Muscle Making the Leap from Earth to Space control in extreme situations 11.50-11.55 11.50-12.00 11.50-12.00 12.15-12.30 environmental factors in the experiment SIRIUS-19 N.A. Vilchinskaya, O.V. Turtikova, S.A. Rozhkov, K.A. Sharlo, S.A. Z.S. Patel, I. Plante, S.R. Blattnig, R.B. Norman, M.P. Little, L.C. E. Soto, V.V. Alexandrov, E.Yu. Bersenev, V.V. Tsetlin, G.P. Stepanova, N.V. Degterenkova, S.O. Fedyay Tyganov, B.S. Shenkman Simonsen, J.L. Huff K.V. Tikhonova, E.S. Tomilovskaya 26 27

April 7, Wednesday April 7, Wednesday Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov Impact of isolation on crew performance during the Accuracy Of Power Maintenance By Muscles Of The Results and prospects of studies of changes in lower limbs SIRIUS-19 campaign 11.55-12.05 12.00-12.10 Shoulder Girdle After 21-Day Dry Immersion 12.10-12.20 veins in exposure to real and simulated microgravity S. Lizy-Destrez, E. Gil Calle, D. Mimoso, V. Martin Estrana, R.N. Roy, E. A. Orlova, O. L. Vinogradova, A. S. Borovik A.V. Salnikov, G.A. Fomina V. Peysakhovich Pressure compression bandages for the treatment of 12.30-12.45 postural hypotension following re-entry Development and integration of a space-fl ight simulator Predictions of heart rate and oxygen uptake during P.A. Johnson, J.C. Johnson, A. Mardon for the SIRIUS Analogue Mission: SIMKSILL-RU and Sensorimotor Tasks During 21-Day Dry Immersionrpinskaya I.I. 12.05-12.15 12.10-12.15 12.20-12.30 exercise for activities in Space SIMSKILL-VR Shoshina, E.S. Tomilovskaya U. Hoff mann, U. Drescher, F. Faber, J. Koschate M.B. Bruguera, S.L. Bermúdez, R. Ewald Eff ect of 5-day Dry Immersion on the human foot Electromagnetic compatibility of cardiovascular and Social research in space and military missions is the morphology assessed by computer plantography and soft respiratory biomedical equipment in ground based studies 12.15-12.20 «HOUSE WITH THREE FLOORS»… 12.15-12.25 tissues stiff ness measuring 12.30-12.40 of human space exploration K. Sykorova Bernardova, P. Tefelnerova, E. Chroustova, R. Bahbouh A.A. Saveko, L.E. Amirova, I.Yu. Ermakov, A.I. Dyachenko, A.V. Orlov, A.V. Suvorov Yu.I. Smirnov, E.S. Tomilovskaya The First Female Dry Immersion (NAIAD- 2020): Experimental estimation of the eff ectiveness of Design and Specifi cs of a 3-Day Study prospective methods of protection of the hearing organ Quantitative Approach Towards an Analysis of Structure E.S. Tomilovskaya, A.A. Saveko, L.E. Amirova, I.N. Nosikova, 12.45-13.00 under conditions of harmful exposure to noise 12.20-12.25 and Dynamics of Social Relationships in Space Crews 12.25-12.35 I.V. Rukavishnikov, R.V. Chernogorov, S.A. Lebedeva, I.Yu Ermakov, L.Yu. Marchenko, E.E. Sigaleva, P. Tefelnerova, K. Bernardova, E. Chroustova, R. Bahbouh Reduced vagal modulations of heart rate during I.I. Ponomarev, I.S. Zelenskaya, T.A. Shigueva, N.V. Shishkin, overwintering in Antarctica O.B. Pasekova, E.I. Matsnev 12.40-12.50 V.V. Kitov, G.Yu. Vassilieva, O.I. Orlov M.A. Maggioni, G. Merati, P. Castiglioni, Three days of dry immersion reduce mitochondrial S. Mendt, H.-C. Gunga, A.C. Stahn Summary of Human Factors Behavioral Performance respiration rate in m. soleus in women 12.25-12.40 Exploration Measures in SIRIUS ‘19 12.35-12.45 E.S. Motanova, R.O. Bokov, T.F. Vepkhvadze, E.M. Lednev, E.S S.T. Bell, P. Roma, J. Miller, S. Whiting, L. Landon .Tomilovskaya, O.I. Orlov, D.V. Popov Examining Teamwork of Space Crewmembers Study Of The Eff ects Of Low-Frequency Electrical and Mission Control Personnel under Crew Autonomy: Myostimulation During 5-Day Dry Immersion On The 12.40-12.55 12.45-12.50 The Advantage of Supine and Standing Heart Rate A Multiteam System Perspective Hyperrefl exia And Vertical Balance Variability Analysis to Assess Training Status and Biomedical support of manned space missions beyond the U. Fischer, K. Mosier N.V. Shishkin, L.E. Amirova, I.N. Nosikova, E.S. Tomilovskaya Performance in a Walking Ultramarathon 12.50-13.00 13.00-13.15 low Earth orbit as an organizational control system M.A. Maggioni, L.C. Rundfeldt, H.-C. Gunga, M. Joerres, G. Merati, Eff ects Of High Frequency Electromyostimulation On Yu.I. Smirnov, E.Yu. Mamonova Characteristics Of The Accuracy Of Control Of Movements M. Steinach 12.55 Discussion 12.50-12.55 Under Dry Immersion Conditions T.A. Shigueva, V.V. Kitov, Yu.A. Koryak, E.S. Tomilovskaya 13.00-14.00 Break, Short Talks 13.00-14.00 Break, Short Talks Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov SIRIUS project. Physiological aspects of isolation and Eff ects of gound-based models of microgravity on cardio- Skeletal Unloading and Other Aspects of Bone Study Under Space Psychology and Human Factors in Interplanetary 14.00-15.30 14.00-15.30 14.00-15.30 14.00-15.30 confi nement vascular, central nervous and other systems the Action of Spacefl ight Factors Missions

V.Abeln/V.Ilyin M. Maggioni/ E. Tomilovskaya L. Vico/ G. Vassilieva N. Kanas/ V. Gushin Chairs: Chairs: Chairs: Chairs: R-r — Yu. Popova R-r — E. Luchitskaya R-r Т. Agaptseva R-r A. Savinkina

Features of dynamics of the professional operators and Cardiovascular and autonomic eff ects of nutritional Subjective perception of time in space fl ights and analogs: volunteers microfl ora in isolation experiments of various supplementation during longterm bed rest study methods 14.00-14.10 14.00-14.10 14.00-14.10 duration M.A. Maggioni, G. Merati, P. Castiglioni, S. Mendt, A.K. Yusupova, V.I. Gushin, D.M. Shved, N.S. Supolkina, A.I. V.K. Ilyin, D.V. Komissarova, N.A. Usanova, Yu.A. Morozova A. Friedl-Werner, K. Brauns, H.-C. Gunga, A. C. Stahn Analysis of osteodensitometry data of cosmonauts after Chekalina the fi rst and repeated fl ights considering the timing of the 14.00-14.15 Hemodynamic Reactions Features Of A Female Body In examination after landing Changes in crew cohesion and habitat use during two Conditions Of «Dry» Immersion K.V. Gordienko, V.E. Novikov, G. Yu. Vassilieva 1-year antarctic winter-over mission 14.10-14.20 M.R. Vasina, E.S. Luchitskaya, 14.10-14.20 M. Basner, D. F. Dinges, A. Stahn, J. Nasrini, E. Hermosillo, Human periodontal tissues state during long-term A.J. Ecker, M. Smith, B. Johannes, B. Healey, F.P. van den Berg, H.C. isolation in confi ned habitat E.S. Tomilovskaya, V.B. Rusanov 14.10-14.15 Gunga, N. Pattyn, T.M. Moore, D. Roalf, R.C. Gur V.K. Ilyin, M.P. Rykova, E.N. Antropova, Z.O. Solovieva, M.A. Skedina, A.A. Kovaleva, A.M. Nosovsky Dynamics of human ventilation response during 21-day «dry» immersion Cognitive styles & multimodal communication codes for 14.20-14.30 K.S. Parshin, Yu.A. Shulagin, R.N. Zaripov, E.S. Ermolaev, A.I. 14.20-14.35 deep space Dyachenko, A.V. Suvorov R. Toscano, A. Toscano 28 29

April 7, Wednesday April 7, Wednesday Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov Manifestation of hemorrhagic syndrome after head-up Eff ects of Thigh-cuff s on bone remodelling unbalance Neuropsychological eff ects of isolation and physical tilt tests in 21-day dry immersion in the form of plasma Visual Dwell Time on instruments is associated with induced by short-term dry immersion and the associated exercise regimen during SIRIUS-19 proteome modifi cation Manual Docking Performance 14.15-14.25 14.30-14.40 14.15-14.30 metabolic markers 14.35-14.45 V. Abeln, T. Klein, F. Möller, U. Hoff mann, J. Popova, E.A. Fomina, G. D.N. Kashirina, L.Kh. Pastushkova, A.G. Goncharova, I.N. S. Piechowski, W. Pustowalow, M. Arz, J. Rittweger, C. Mühl, E. M.T. Linossier, L. Peurière, M. Normand, M.P. Bareille, Vassilieva, S. Schneider Goncharov, I.V. Rukavishnikov, A.G. Brzhozovskiy, A.S. Kononikhin, Mulder, O. T. Wolf, J. Jordan A. Beck, C. Bonneau, G. Gauquelin-Koch, L. Vico M.I. Koloteva, E.S. Tomilovskaya, I.M. Larina Eff ect of 3-day «dry» immersion on the veins condition in The Eff ects of 120 Days Confi nement During the SIRIUS the lower extremities of healthy women of reproductive Project on Physiological Kinetics and Inhibitory Control 14.25-14.35 14.40-14.50 age (NAYADA-2020) F. Möller. , J. Koschate. , M. Haeger. , U.Hoff mann, E.A. Fomina, N. I.M. Vasilev, O.I. Efremova , S.G. Gavrilov , Modeling of bone organs under the infl uence of external Didkovskaya, U. Drescher, F. Steinberg E.S. Tomilovskaya, G.Yu. Vassilieva force factors Sexual wellbeing & sexual security in isolation & 14.30-14.45 T.V. Baltina, V.V. Yaikova, 14.45-14.55 confi nement environments Novel antimicrobial fl eece inhibits growth of human- Evaluation and assessment of hemodynamic regulation — A.O. Fedianin, M.E. Baltin, N.V. Kharin, O.V. Gerasimov, O.A. D. Grevers, T. Amelung, M.A. Maggioni, N. Pattyn, H- C. Gunga derived biofi lm-forming Staphylococci during the Infl uences of the leg position during tilt testson left ventricular Sachenkov 14.35-14.45 SIRIUS-19 isolation 14.50-15.00 stroke volume E. Grohmann, D. Wischer, D. Schneider, A. Poehlein, J. Koschate, F. Möller, Z. Acar, E. Jacobi, U. Hoff mann O. Wagner, S. Kharin, N. Novikova, R. Haag, R. Daniel Analysis of bacterial profi les of AGBRESA participants — Gender characteristics of the metabolic reactions of a study concerning terrestrial astronauts under simulated volunteers an experiment with 120-day isolation in a microgravity 14.45-14.55 pressurized volume the background of stressful infl uences 15.00-15.10 E. Muratov, A. Himmelmann, A. Schröder, S. Koch, K. Siems, E. Thermoneutral temperature mitigates hind-limb A.A. Markin, O.A. Zhuravleva, D.S. Kuzichkin, L.V. Vostrikova, I.V. unloading-induced bone loss by preserving energetic Mulder, C. Hellweg, P. Frings-Meuthen, C. Moissl-Eichinger, U. MSG — Movement Space and Group health in a restricted area Zabolotskaya, Y.V. Zhuravleva 14.45-15.00 metabolism 14.55-15.05 Rolle-Kampczyk, K. Förstner, R. Moeller D. Michaeli, T. Carmel, M. Rozložnik, K. Brünnemann L. Peurière, C. Mastrandrea, M.-T. Linossier, M. Paul, A. Vanden- Sleep and autonomic nervous system during a 4-months Gravity-dependent changes in the functional state of the Bossche, M.-H. Lafage-Proust, L. Vico 14.55-15.05 isolation experiment 15.10-15.20 neuromotor apparatus of the rat calf muscles N. Laharnar, M. Glos, A.V. Suvorov, A.V. Demin, T. Penzel, I. Fietze A.A Eremeev, A.O. Fedianin, T.N. Zaytseva, A.N. Babikova, T.V. Baltina

Study of autonomic regulation of circulation in conditions 15.05-15.15 of prolonged isolation A. Chernikova, O. Isaeva, O. Uss Whole-body vibration: an 18 month countermeasure Habitats in Extreme Environment and Habitability — Gravity and mastoid eff usion evaluation of postmenopausal women 15.00-15.15 15.05-15.20 A Review 15.20-15.25 L. Lecheler, F. Paulke, L. Sonnow, U. Limper, D. Schwarz, S. Jansen. P. Fernandez , H. Locrelle, C. Bonneau, M. Normand, Sleep loss and high task demand lead to fast and sloppy J. Tank, J. Jordan, J.P. Klussmann S. Haeuplik-Meusburger, S. Bishop decision-making: eye-tracking evidence from a visual M.-H. Lafage Proust, T. Thomas, L. Vico 15.15-15.25 search task C. Mühl, S. Benderoth, D. Aeschbach

Study of the state of the auditory analyzer of the testers Assessment of the female operators‘ psychophysiological Lower body negative pressure: current updates and Rat bone tissue in conditions of limited motor activity in the dynamics of a 4-month experiment with isolation state under simulated microgravity using acoustic speech 15.25-15.30 15.25-15.30 perspectives 15.15-15.30 T.V. Baltina, N.N. Kuntush, A.O.Fedyanin, M.E. Baltin, N.V. Kharin, 15.20-15.30 «SIRIUS-19» analysis N. Goswami, A. Blaber, S. Du Plessis O.V. Gerasimov, O.A. Sachenkov I.V. Kutina S. Lebedeva, D. Shved, A. Savinkina

15.30-16.30 Discussion 15.30-16.30 Discussion 15.30-16.30 Discussion 15.30-16.30 Discussion 16.30-17.00 Coff ee Break, Short Talks 16.30-17.00 Coff ee Break, Short Talks Hall Mussorgsky Hall Mussorgsky 17.00-18.00 Plenary session 17.00-18.00 Plenary session Developing Autonomous Medical Capabilities for Exploration Spacefl ight Developing Autonomous Medical Capabilities for Exploration Spacefl ight 17.00-17.20 17.00-17.20 K. Lehnhardt, B. Easter K. Lehnhardt, B. Easter NASA Human Research Program — Overview of Behavioral Health and Performance Research in the SIRIUS Analog NASA Human Research Program — Overview of Behavioral Health and Performance Research in the SIRIUS Analog 17.20-17.40 17.20-17.40 A. Whitmire, B. Gore, B. Vessey, T. Williams A. Whitmire, B. Gore, B. Vessey, T. Williams The human research program suite of integrated one-year mission experiments (CIPHER): description and integration The human research program suite of integrated one-year mission experiments (CIPHER): description and integration 17.40-18.00 17.40-18.00 M. Shelhamer, Ch. Oubre M. Shelhamer, Ch. Oubre 18.00-18.30 Discussion 18.00-18.30 Discussion 30 31

April 8, Thursday April 8, Thursday 08.00-09.00 Registration and Connecting participants, Technical Information 08.00-09.00 Registration and Connecting participants, Technical Information Hall Mussorgsky Hall Mussorgsky 09.00-10.00 Plenary session 09.00-10.00 Plenary session Planetary protection in interplanetary missions: problems, challenges and solutions Planetary protection in interplanetary missions: problems, challenges and solutions 09.00-09.20 09.00-09.20 V.K. Ilyin V.K. Ilyin Brain Changes in Response to Isolation and Confi nement: heT Need for Target-Specifi c Countermeasures Brain Changes in Response to Isolation and Confi nement: heT Need for Target-Specifi c Countermeasures 09.20-09.40 09.20-09.40 A. Stahn A. Stahn The impact of spacefl ight in the vestibular system and the brain The impact of spacefl ight in the vestibular system and the brain 09.40-10.00 09.40-10.00 F.L. Wuyts F.L. Wuyts Hall Mussorgsky Hall Mussorgsky Young Scientists Young Scientists Round Table Round Table 10.00-10.40 Dmitry Aleksandrovich Shishkin — Director of the Department for Personnel Development and Project Support, Roscosmos State Corporation. 10.00-10.40 Dmitry Aleksandrovich Shishkin — Director of the Department for Personnel Development and Project Support, Roscosmos State Corporation. Dmitriy Kobets — Young Scientists & Professionals Council of Space Research Institute of the Russian Academy of Sciences Dmitriy Kobets — Young Scientists & Professionals Council of Space Research Institute of the Russian Academy of Sciences Yuriy Igorevich Smirnov — head of laboratory of biomedical programs IBMP Yuriy Igorevich Smirnov — head of laboratory of biomedical programs IBMP Moderator: A. Stepanova Moderator: A. Stepanova 10.40-11.00 Coff ee Break, Short Talks 10.40-11.00 Coff ee Break, Short Talks Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov Exercise and Countermeasures in the Interplanetary Skeletal Muscle Under Conditions Of Real And Simulated Habitability, Nutrition and Life Support in Space 11.00-13.00 11.00-13.00 11.00-13.00 11.00-12.20 Commercial Spacefl ight Missions, Countermeasure Evaluation Microgravity. Part 1 Exploration Chairs: S. Schneider/ E. Fomina / R-r S. Smoleevskiy Chairs: J. Rittweger/ B. Shenkman / R-r S. Tyganov Chairs: K. Beblo-Vranesevic /V. Ilyin / R-r K. Shef Chairs: V.S. Zander/ I. Saenko / R-r A. Savinkina Microbial Monitoring in the EDEN ISS Greenhouse, Space technologies in the neurorehabilitation a Mobile Test Facility in Antarctica 11.00-11.10 11.00-11.15 O.Ya. Kochuneva, V.G. Mitkovsky, I.V. Saenko Сoordination among the lower limb muscles during K.Beblo-Vranesevic, J. Fahrion, P. Zabel, D. Schubert, Inactivity and unloading as determinants of muscle locomotion on the passive-mode treadmill in Mars500 and M. Mysara, R. Van Houdt, B. Eikmanns, P. Rettberg 11.00-11.10 11.00-11.30 impairment in microgravity in the long-term space fl ight Linking biomedical research and technological innovation C. Reggiani Operation of the Russian «Electron-VM» Oxygen A. Meigal, D. Ivanov, A. Smoleevskii, U. Monakhova, E. Fomina for Human health in Space and on earth — Overview of 11.10-11.20 Generation System aboard the International Space Station 11.15-11.30 current projects and future plans in the: envihab V.Yu. Proshkin M. von der Wiesche, A. Noppe, A. Nitsche, J. Jordan PRBS kinetics test as tool to determine eff ectiveness of E-Nose technique application in the diagnosis of pneumonia Mitigating muscle and bone loss during spacefl ight: GSK3 The optimality criteria for crop lighting inside plant physical training T. Woehrle, S. Matzel, F. Pfeiff er, L. Kamm, D. Moser, 11.10-11.25 11.30-11.50 as a potential cellular target 11.20-11.30 growth unit for extended manned space missions 11.30-11.40 U. Hoff mann, J. Koschate, N.Yu. Lysova, L. Thieschäfer, M. Feuerecker, J. Grosser, J. Lenic, S. Zander Vanja, V. Fajardo A.A. Buryak, Yu.A. Berkovich, O.A. Ochkov U. Drescher, E.A. Fomina O. Schoele-Schulz, M. Dolch, V. Fetter, A. Choukér The water management on prospective space stations Aerospace medicine in the fi ght against coronavirus Changes in motor control depending on the level of 11.30-11.40 L.S. Bobe, A.A. Kochetkov, A.S. Tsygankov, S. Yu. Romanov, 11.40-11.50 infection 11.25-11:30 physical performance in space fl ight A.G. Zeleznyakov, P.O. Andreychuk, Y.E. Sinyak I.P. Levchuk, A.A. Medenkov N.Yu. Lysova, E.A. Fomina Modeling of EEG signals via Partial Directed Coherence and Continuous and intermittent artifi cial gravity as a Deep Learning for the identifi cation of suitable artifi cial countermeasure to the cognitive eff ects of 60 days of gravity levels in a Short Arm Human Centrifuge as part of 11:30-11.45 11.50-12.00 head-down tilt bed rest rehabilitation of patients with neurological disorders S.N. Ketseridou , I. Machairas , C. Giantsios , C. Frantzidis, M. Basner , D. Dinges, K.Howard, T. Moore, R. Gur, C. Mühl, A. Stahn C. Plomariti , P. Kourtidou-Papadeli Plantar aff erent stimulation eff ects in postural muscle. The rationale of the key trace contaminants list for Characteristic features of human adaptation to long-term 11.50-12.20 Lessons from human and rat studies 11.40-11.50 chemicals, polluting the air of manned spacecraft Biosensory medical technology for non-invasive diagnostics of space fl ights on the International Space Station B.S. Shenkman, S.A. Tyganov A.A. Pakhomova, L.N. Mukhamedieva, D.S. Ozerov oxidative stress based on the biomarkers in exhaled breath 11.45-11.55 12.00-12.10 I.A. Nichiporuk, S.A. Chistokhodova, E.A. Fomina, T.B. Kukoba, D.S. Ozerov, L.N. Moukhamedieva, J. Grosser, J. Lenic, A. Choukér, N.Yu. Lysova, T.V. Zhuravleva, A.N. Agureev M. Dolch, Yu. Smirnov, D. Tsarkov, O. Schoele-Schulz, V. Fetter Device for mechanical urine collection in women in Possibilities for treating sensorimotor disturbances in 12.10-12.20 microgravity and clinical use astronauts and cosmonauts after long-duration space fl ights S.A. Lebedeva, N. Komarov, M. Stern 11.55-12.10 M.F. Reschke, E.S. Tomilovskaya, M.J. Rosenberg, I.S. Kofman, Promising research areas for the operational control over the 12.20-13.00 Space Tourism I.V. Rukavishnikov, V.V. Kitov,N.Yu. Osetsky, 11.50-12.05 human health toxic risks in long-term manned space fl ights G. Clement, N. Gadd, S. Wood D.S. Ozerov, L.N. Mukhamedieva Chairs: A. Kuritsyn, A. Kumar, R-r N. Chub 32 33

April 8, Thursday April 8, Thursday Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov Peripheral Cooling in the Human Short Arm Centrifuge Directions of commercialization of manned space 12.10-12.20 Can Reduce Orthostatic Intolerance 12.20-12.30 exploration O. Opatz, H-C. Gunga, N. Kagelmann The role of muscle tone in the genes expression regulation A.A. Kuritsyn, B.I. Kryuchkov, A.A. Kovinskiy that control the destruction of contractile and cytoskeletal Solving nutrition Problems in Interplanetary Space Flights 12.20-12.40 12.05-12.20 Acute eff ect of hyper gravity on the neuromuscular control proteins of unloaded rat soleus A.N. Agureev, K.A.Shef in drop jumps and drop landings Governance of space tourism 12.20-12:30 T.L. Nemirovskaya 12.30-12.40 J. Waldvogel, K. Freyler, K. Albracht, B. Stäudle, E. Monti, M. Helm, A. Jha , A. Kibe, A. Kumar Sinha, V.R Lalithambika A. Gollhofer, M. Narici, R. Ritzmann Adenosine Biomarker Alterations during a 60 day Head Bioreactor technology as key component of providing food Down Tilt Bed-Rest Study. Potential role of reactive sledge 12.30-12.40 12.20-12.30 products astronaut in far space countermeasure. D.V. Maklakov, S.V. Nadezhdin C. Nday, C. Frantzidis, P. Bamidis, C. Kourtidou-Papadeli Approach for evolving medical criterions & human The eff ect of previous spacefl ight on otolith-mediated 12.40-12.50 tolerance limits for future space tourists ocular counter-roll in cosmonauts after long duration Skeletal muscle atrophy in disuse and microgravity: Mathematical prediction of gas release from polymers A. Kumar, A. Jha, A. Kibe, A.Kumar Sinha 12:40-12:50 spacefl ight cellular and molecular analyses on mice and human 12.30-12.40 used onboard the manned spacecrafts 12.40-13.00 C. Schoenmaekers, L. Kornilova, D. Glukhikh, G. Clément, models P.V. Lashukov, D.S. Ozerov, N.A. Kotelnikov H. MacDougall, I. Naumov, Ch. De Laet, L. Wille, S. Jillings, F. Wuyts R. Bottinelli Morphological characteristics of blood vessels and cytokine Intellectual property commercial issues embracing the The impact of long-duration spacefl ight on the horizontal regulation of compensatory reactions in the respiratory transfer of data between orbital stations: the example of Vestibulo-Ocular Refl ex (hVOR) 12:50-13:00 12.40-12.50 organs of rats under the experimental fl uid shift in the 12.50-13.00 the lunar gateway orbital station and the international Ch. De Laet, L. Kornilova, D. Glukhikh, C.Schoenmaekers, H. cranial direction space station MacDougall, S.T. Moore, I. Naumov, L. Wille, S. Jillings, F. Wuyts M.Yu. Barantseva, L.N. Mukhamedieva, O.A. Dadasheva, D.S. Ozerov J. Sandalinas 13.00-14.00 Break, Short Talks 13.00-14.00 Break, Short Talks Place Museum of Cosmonautics Place Museum of Cosmonautics 15.00-17.00 60th Anniversary of the First Human Space Flight 15.00-17.00 60th Anniversary of the First Human Space Flight R. Pischel, N. Artyukhina, M. Belakovskiy, R. Pischel, N. Artyukhina, M. Belakovskiy, Chairs: Chairs: R-r A. Kussmaul R-r A. Kussmaul Gagarin`s herritage in museum collections of Russia Gagarin`s herritage in museum collections of Russia 15.00-15.30 15.00-15.30 V.L. Klimentov, M.S. Belakovskiy V.L. Klimentov, M.S. Belakovskiy

France-USSR / Russia Cooperation in the Medico-Biological Field: The Success Story in Human Space Flights and Automatic Flights France-USSR / Russia Cooperation in the Medico-Biological Field: The Success Story in Human Space Flights and Automatic Flights 15.30-15.50 15.30-15.50 Christian Lardier , Lada Lekai and Galina Fomina Christian Lardier , Lada Lekai and Galina Fomina

The road to cosmonautics of Military Medic I.A.Kolosov The road to cosmonautics of Military Medic I.A.Kolosov 15.50-16.00 15.50-16.00 V.N. Kupriyanov V.N. Kupriyanov

Day of triumph of cosmonautics Day of triumph of cosmonautics 16.00-16.15 16.00-16.15 A.A. Medenkov, M.V. Dvornikov A.A. Medenkov, M.V. Dvornikov 16.15-17.00 Tour 16.15-17.00 Tour Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov The Problems of Muscle Immunology Artifi cial Intelligence, VR, Telemedicine in Interplanetary 14.00-15.20 Education and Outreach in Space Sciences 14.00-15.30 14.00-15.10 14.00-15.30 Part 2 and Biochemistry for Personalized Space Medicine Missions and on the Earth Ch.Rogon/ L. Buravkova A. Stahn/A. Smoleevskiy Chairs: Chairs: C. Reggiani/ B. Shenkman R-r S. Tyganov Chairs: A. Chouker/ S. Ponomarev R-r A. Pakhomova Chairs: R-r D. Kashirina R-r D. Shved Human spacefl ight outreach — challenges and strategy Deregulation of costamere components in unloading Fibrinolytic system status after space fl ights Artifi cial intelligence technologies in the system of 14.00-14.15 for a developing nation 14.00-14.20 muscle atrophy 14.00-14.10 D.S. Kuzichkin, A.A. Markin, O.A. Zhuravleva, Z.A. Krivitsina, T.V. 14.00-14.10 accounting for the capabilities and abilities of cosmonauts A. Kibe, A. Jha, A. Kumar Sinha L. Gorza Zhuravleva, L.V. Vostrikova, M.I. Koloteva, I.V. Zabolotskaya N.M. Kozlova, A.A. Medenkov The eff ect of 4-month isolation in a pressurized facility on Inter-individual and intra-individual variation of Increasing Medical Students’ Accessibility to Aerospace the phenotypic characteristics of dendritic cells obtained The role of ai powered autonomous avionic systems in spacefl ight-induced muscle atrophy: Results from the 14.15-14.30 Medicine with an Online Course 14.20-14.40 14.10-14.20 from human peripheral blood monocytes 14.10-14.20 interplanetary spacefl ight EDOS-2 study T. Girgla, R. Ferguson O.V. Kutko, S.M. Shulgina, S.A. Kalinin, E.N. Antropova, M.P. Rykova, B. Bibhorr J. Rittweger K.D. Orlova, V.A. Shmarov, D.D. Vlasova, A.A. Sadova, S.A. Ponomarev 34 35

April 8, Thursday April 8, Thursday Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov Key Predictors to Successfully Cope with the Yukon Arctic Ultra: The Longest and the Coldest Ultramarathon Ai based classifi cation algorithms to identify warning signs Space Policy, Management Systems, Public Sector 14.30-14.45 14.20-14.30 C. Kienast, L. Mascarell-Maricic, R. Coker, A. Schalt, M. Wypukol, 14.20-14.30 during continuous monitoring of physiological parameters SXT Ariel N.Genov, D. Grevers, M. Joerres, R. Mole, O. Opatz, H-C. Gunga, P.Biswal, S.Mishra, A. Jha, A. Kibeand, A. Kumar Sinha Regulation of skeletal muscle titin expression during M. Steinach 14.40-14.55 unloading I.M. Vikhlyantsev Interrelation of success in adaptation to conditions of space fl ights with initial biochemical and neurohormonal Automatic primary medical diagnostics of cosmonauts on Aerospace Science Popularization Education 14.45-15.00 14.30-14.45 status of cosmonauts 14.30-14.40 long interplanetary expeditions X. Huifeng I. Nichiporuk, O. Zhuravleva,A. Markin, D. Kuzichkin, S. O.V. Perevedentsev, R.V. Chernogorov, V.M. Levanov Chistokhodova, T. Zhuravleva, L. Vostrikova First results of the human innate immunity research during the 21-day “dry” immersion with an artifi cial Automation of onboard crew health monitoring system The relevance of Anticipation to the Searches for Alien Life gravity used as a countermeasure using artifi cial intelligence algorithms 15.00-15.10 in Astrobiology 14.45-14.55 14.40-14.50 S.A. Ponomarev, S.M. Shulgina, S.A. Kalinin, S. Kumar, B. Pal Singh, A. Kibe, A. Jha, A. Kumar Sinha, V.R. G. Profi tiliotis Sex-based diff erences in muscle response in rats exposed E.N. Antropova, M.P. Rykova, K.D. Orlova, O.V. Kutko, V.A. Shmarov, Lalithambika 14.55-15.15 to micro- and partial- gravity analogs D.D. Vlasova, A.A. Sadova M. Mortreux Psychological support based on virtual reality in simulation experiments, isolation and space fl ights 14.50-15.00 I. Rozanov , V.Gushin, O. Rumin, O. Karpova, D.M. Shved, P. Kuznecova, A.O. Savinkina, R. Abdyuhanov Education and training in space biology and medicine: the The E-Nose Breath Gas Experiment J. Grosser, J. Lenic, J. Schmitz, V. Zander, A. Choukér, L.N. Virtual reality based simulator training for potentially 15.10-15.20 experience of Institute of Biomedical Problems of RAS 14.55-15.10 E.V. Sotnezova, M.A. Levinskikh, E.V. Ezdakova, I.V. Andrianova Moukhamedieva, D.S. Ozerov, M. Dolch, O. Schoele-Schulz, 15.00-15.10 dangerous and life critical emergency rehearsals V. Fetter P. Biswal , S. Mishra, A. Jha , A. Kibe, A. Kumar Sinha Sphingolipids take part in regulation of muscle plasticity A vision on psychological support in future interplanetary 15.15-15.30 during gravitational unloading 15.10-15.20 spacefl ights I.G. Bryndina, A.V. Sekunov, V.V. Skurygin I. Rozanov, O. Rumin, O. Karpova, V. Gushin, D. Shved The Perception of Self-Motion in Microgravity 15.20-15.30 15.20-16.30 Discussion 15.10-16.30 Discussion Laurence R. Harris 15.30-16.30 Discussion 15.30-16.30 Discussion 16.30-17.00 Coff ee Break, Short Talks 16.30-17.00 Coff ee Break, Short Talks Hall Mussorgsky Hall Mussorgsky 17.00-18.00 Plenary session 17.00-18.00 Plenary session Development of the design of a countermeasure system for Moon and interplanetary missions in ground and space experiments Development of the design of a countermeasure system for Moon and interplanetary missions in ground and space experiments 17.00-17.20 17.00-17.20 E.V. Fomina E.V. Fomina

Standard Measures during Spacefl ight Standard Measures during Spacefl ight 17.20-17.40 17.20-17.40 G. Clement G. Clement

Past, Present, Future of Exercise and Human Performance in Space Past, Present, Future of Exercise and Human Performance in Space 17.40-18.00 17.40-18.00 M. Downs M. Downs 18.00-18.30 Discussion 18.00-18.30 Discussion 18.30-18.50 Closing Remarks 18.30-18.50 Closing Remarks 36 37

April 9, Friday — Business Day SHORT TALKS

10.00-13.00 18th DLR/IBMP Life Sciences Working Group Meeting (Restricted access) Section Name Report Chairs: O.I. Orlov, M. Braun Astrobiology, Space Biology and Space Biotechnology April 6 Signifi cant (in dozen times) attenuation of gamma-radiation induced 13.30-14.30 Seminar on the problems of eff ects of social isolation (Open access) AB-01 S.A. Bulat, V.N. Verbenko, T.L. Yaroshevich, V.S. Cheptsov dsDNA damage at – 195.8 temperature exposure Chairs: V. Gushin Neurophysiology and psyсhophysiology of operator activity April 6 15.30-20.30 NASA/IBMP Joint Working Group Meeting (Restricted access) EEG complexity features based machine learning discriminates between NS-01 S. Güney, H. Akbulut, H.B. Çotuk, A.D. Duru diff erent mental workload states in terrestrial and lunar gravity analog Chairs: O.I. Orlov, C. Kundrot Ch.A. Frantzidis, I. Machairas, S. Gylou, Ch.M. Nday, S.N. Ketseridou, The technical part of the Business Day is supported by the Ministry of Science and Higher Education of the Russian Federation in the frame of the project “Pavlov Center for Integrative Physiology to Medicine, M. Mitsiou, Ch. Giantsios, Ch.S. Plomariti, M. Velana, A. Xatzicharistou, Investigating neuroplasticity induced changes due to artifi cial gravity NS-02 High-tech Healthcare and Stress Tolerance Technologies”. A. Karkala, D. Kontaxopoulou, E. Stanitsa, S. Fragkiadaki, training through cortical functional connectivity & network analysis S.G. Papageorgiou, P. Bamidis, Ch. Kourtidou-Papadeli, J. Vernikos Neuroscience problems in Deep Space Missions April 6 Eff ects of two months of bed rest and antioxidant supplementation on NS-PS-01 K. Brauns, A. Friedl-Werner, H.C. Gunga.,A.C. Stahn attentional processing

A.A. Naumova, A.V. Khramtsova, A.S. Berezovskaya, E.A. Lavrova, M.V. Short-term hindlimb unloading impairs dopaminergic regulation in the NS-PS-02 Glazova striatum of mice

Infl uence of gravity on organization of eye movements and visual NS-PS-03 I.E. Rabichev perception

A.C. Stahn, M. Riemer, T. Wolbers, D.F. Dinges, A. Friedl-Werner, NS-PS-04 Altered Gravity Conditions Impair Spatial Cognition K.Brauns, S. Besnard, P. Denise, S. Kühn, H.C. Gunga

L. Kalinski, S. El Sheikh, C. Peter, Y. Lichterfeld, H. Weber, R. Hemmersbach, NS-PS-05 Enhancing Synaptic Plasticity in vitro using Novel Ketamine Derivatives J. Jordan, C. Liemersdorf

Multidisciplinary Studies related with Humans in Space April 6 MU-01 A.K. Martusevich, A.G. Galka, E.S. Golygina, A.N. Tuzhilkin, A.S. Fedotova Crystalloscopic test-system for cold plasma eff ects etectiond MU-02 A. Winters Mitigating the eff ects of Space Adaptation through Vestibular Yoga Training Infl uence of hypomagnetic conditions in long-term space fl ights April 6 The Functional State Of The Human Hearing System And The Brainstem HP-01 O.B. Pasekova, E.E. Sigaleva Acoustic Structures In The Simulated Hypomagnetic Field

A.V. Medvedeva, E.V. Tokmacheva, E.A. Nikitina , S.A. Vasilieva, V.E. Role Of Stress Impacts Of Weakened Geomagnetic Field On Drosophila HP-02 Stefanov, S.V. Surma, B.F. Shchegolev, E.V. Savvateeva-Popova Memory Formation

New approaches and concepts for SANS/VIIP risk prevention April 6 Dynamics Of Visual Acute And Contrast Sensitivity In Winter Conditions At SANS-01 O.M. Manko, N.Yu. Oseckij, M.A. Gracheva, S.A. Koskin, S.Yu. Golubev The “Vostok” Antarctic Station

Clinical and morphological portrait of cataract in dynamics from the UV SANS-02 Sh. Khan index according to Pakistani statistics

S. Jillings, A.Van Ombergen, E. Tomilovskaya, A. Rumshiskaya, L. Litvinova, I. Nosikova, E. Pechenkova, I. Rukavishnikov, SANS-03 Spacefl ight-induced macro- and microstructural changes in the brain S. Sunaert, P.M. Parizel, V. Sinitsyn, V. Petrovichev, S. Laureys, P. zu Eulenburg, J. Sijbers, F.L. Wuyts, B. Jeurissen

Radiation during deep space exploration: risk estimation and countermeasure April 6 O.A. Ivanova, V.A. Shurshakov, S.G. Drobyshev, RAD-01 Space Radiation Factor during the Flight of Biological Satellites K.O. Inozemtsev, R.V. Tolochek 38 39

Research Of Composite Material For Improving Personal Protection 60th Anniversary of the First Human Space Flight April 8 RAD-02 V.M. Skorkin, M.N. Lifanov Means Under Gamma Radiation ANN-01 M.V. Dvornikov, A.A. Medenkov Founders of biomedical training of manned space fl ights RAD-03 R.G. Hinshaw, J. Park, D.Y. Kim, R.E. Tanzi, C.A. Lemere New Human Neural Cell Models of Low-Dose Space-Like Radiation Exposure ANN-02 A.A. Medenkov Biomedical training of the fi rst manned space fl ight K. Fish, M. K. Khlgatian, C. Grano, M. Bisserier, S. Zhang, Longitudinal evaluation of cardiac function and structure in apoe null and Skeletal Muscle Under Conditions Of Real And Simulated Microgravity, RAD-04 A. Brojakowska, V. Chepurko, E. Chepurko, V. Gillespie, Y. Dai, April 8 C57BL/6J mice after gamma and space-type radiation exposure The Problems of Muscle L. Hadri, R. Kishore, D.A. Goukassian Transient activation of slow myosin expression after 3 days of rat hindlimb SM-01 I.D. Lvova Medical Support in the Autonomous Flight April 7 unloading is caused by calcium ions accumulation

Zh. Alimbayeva, Ch. Alimbayev, Application Of A Neural Network In A Mobile Device To Monitor Role of ATP-dependent signalling in rat soleus muscle under hindlimb MS-01 SM-02 K.A. Zaripova N. Bayanbay, K. Ozhikenov, O. Bodin The State Of An Astronaut’s Heart During A Flight unloading

MS-02 A.V. Polyakov, S.O. Fedyay, A.R. Niyazov Human pain threshold in space fl ight The eff ect of electrical stimulation of rat hindlimb during 1-day mechanical SM-03 V.E. Kalashnikov unloading on KCC2 phosphorylation in motoneurons and anabolic and MS-03 F.M. Shvetsky, V.I. Potievskaya, V.S. Shiryaev, M.B. Potievsky Motives for using the «ideal anesthetic» xenon catabolic markers in soleus muscle Stochastic And Singular Analysis Of Fractal Signals For Space Biomedicine MS-04 V.B. Kulikov Systems The role of histone deacetylase 4 in the regulation of slow myosin SM-04 I.I. Paramonova expression at the early stage of gravitational unloading Use Of Virtual Reality Technologies In The Process Of Medical And in the rat soleus muscle MS-05 Yu.A. Bubeev, O.O. Ryumin Psychological Support Of Interplanetary Expeditions Fibro-adipogenic progenitor cells functions are altered during gravitation SM-05 M.Y. Komarova Changes in Cardiovascular and Pulmonary Systems as a Risk of Interplanetary unloading April 7 Missions The potential role of nitric oxide in the maintenance of ribosome biogenesis SM-06 S.V. Rozhkov F. Hoff mann, J. Hoenemann, J. Rabineau, D. Mehrkens, D.A. Gerlach, Orthostatic tachycardia and functional cardiac response following strict in unloaded rat soleus muscle CV-01 S. Moestl, B.W. Johannes, E.G. Caiani, P.-F.Migeotte, J. Jordan, J. Tank head-down-tilt bedrest SM-07 S.P. Belova Restricted activity and protein synthesis in postural and locomotor muscles Gravity factor in determination of hemodynamics regulatory setting in CV-02 L.R. Dilenyan, G.S. Belkaniya, A.K. Martusevich Support aff erentation coregulates slow myosin expression and human SM-08 K. Sharlo mitochondrial biogenesis and prevents unloading-induced fatigue in rat SIRIUS project April 7 soleus muscle N. Laharnar, M. Glos, M. Zemann, J. Schlagintweit, J. Fatek, A.V. Suvorov, Assessing and comparing eff ects of sleep restriction and sleep Changes in knee and ankle torque generation during a six-month space SS-01 SM-09 M.S. Laughlin, Y.A. Koryak, J. Rittweger A.V. Demin, Th. Penzel, I. Fietze fragmentation on the autonomic nervous system — a pilot study (ANSISS) fl ight mission

Skeletal Unloading and Other Aspects of Bone Study Under the Action of Exercise and Countermeasures in the Interplanetary Missions, Countermeasure April 7 April 8 Spacefl ight Factors Evaluation

The content of hormones and markers of bone metabolism in the blood of Strength-to-weight index at readaptation BO-01 N.A. Lukicheva, K.V. Gordienko, A.Yu. Ratushnyy, G.Yu. Vassilieva CT-01 P.V. Romanov, T.B. Kukoba, D.R. Babich, E.V. Fomina rats after 7-day antiorthostatic suspension with the use of denosumab to Earth conditions after repeated space fl ights

Space Psychology and Human Factors in Interplanetary Missions April 7 Preliminary Results Of Studying The Human Body Physiological Activities In CT-02 M.I. Koloteva, Т.М. Glebova Simulated Microgravity With Regular Artifi cial Gravity Sessions On A Short- Preliminary results of a comparative study of the human Arm Centrifuge SP-01 S. Lebedeva, D. Shved psychophysiological state under simulated microgravity without countermeasures and with the use of centrifugation Mathematical modeling of the reaction of physiological systems of the body CT-03 Lobanov, O.I. Orlov to the conditions of artifi cial gravity during preventive measures of adverse Habitability, Nutrition and Life Support in Space Exploration April 8 eff ects of weightlessness

Simulation modeling as an important tool for the production of life-support Development of software for evaluation of the eff ectiveness of LS-01 Shustrov T.L. systems CT-04 D. Grdlichko, E. Fomina countermeasures for negative eff ects of prolonged exposure to weightlessness LS-02 B.F. Zaretsky, V.Y. Proshkin Planetary base automated control system Benefi ts Beyond: Mindful Missions in Autonomy Study of the eff ect of a radiation-chemical factor on the intestinal CT-05 A. Winters LS-03 K.A. Shef, V.K. Ilyin, N.A. Usanova, M.Yu. Barantseva Creating an adaptive experience through movement. microbiome of rats CT-06 G.Yu. Klishin, V.N. Filatov, A.V. Bogomolov, A.A. Shishov Computer system for statoergometric testing Microecology of the Functional Cargo Block (FGB) under conditions of long- LS-04 A.A. Dymova, K.A. Shef , O.V. Malina, S.N. Zaitsev, S.V. Poddubko term operation

M.K. Biswal, N. Basanta Das., LS-05 Biological Risks and Its Implications for Crewed Interplanetary Missions R.N. Annavarapu 40 41

SPEAKERS SPEAKERS

Name Surname Organization Country Name Surname Organization Country Laurie J. Abadie National Aeronautics and Space Administration USA Anton Eremeev Kazan Federal University Russia Vera Abeln Deutsche Sporthochschule Köln Denmark Val A. Fajardo Brock University Canada Alekander Agureev Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Stefania Fedyay Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Jitka Annen University of Liège Belgium Ch. Feichtinger International Astronautical Federation (IAF) France Anastasia Avdeichik Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia P. Fernandez United Kingtom Tatyana Baltina Kazan Federal University Russia Svetlana Fialkina Russia Olga Bannova University of Houston USA Ute Fischer Georgia Institute of Technology USA Mariya Barantseva Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Elena Fomina Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia G. Barisano Keck School of Medicine of USC University of Southern California USA Polina Fortygina Russia Mathias Basner University of Pennsylvania USA Christos Frantzidis Aristotle University of Thessaloniki Greece Kristina Beblo-Vranesevic German Space Agency(DLR) Germany Taania Girgla University of Michigan USA Suzanne T. Bell National Aeronautics and Space Administration USA Igor Goncharov Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Evgeniy Bersenev Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia A.G. Goncharova Kristina Betts Research Institute of Occupational Medicine named after Academician N. F. Izmerov(IRIOH) Russia Kirill Gordienko Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Eng. Bibhorr IU International University Germany Brian F. Gore National Aeronautics and Space Administration(NASA) USA Hasan Birol Çotuk Marmara University Turkey Alexandra Gornostaeva Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Malik Bisserier Icahn School of Medicine at Mount Sinai USA Nandu Goswami Medical University of Graz Auenbruggerplatz Austria Leonid Bobe Research and Design Institute of Chemical Engineering(NIICHIMMASH) Russia David A. Goukassian Icahn School of Medicine at Mount Sinai USA Jonas вместо J. Boecker Rittweger German Aerospace Center Germany Darya Grdlichko Russia Miguel Bosch Bruguera Germany Dorothée Grevers Charité – Universitätsmedizin Berlin Germany Roberto Bottinelli The University of Pavia Italy Elisabeth Grohmann Beuth Hochschule für Technik Berlin Germany Katharina Brauns Charité – Universitätsmedizin Berlin Germany Jan Grosser German Space Agency(DLR) Germany Karin Brünnemann Project Management Institute, Society for Intercultural Education, Training and Research Slovakia Aleksandr Guridov Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Andrey Buryak State Research Centre Of the Russian Federation - The RAS Innstitute of Biomedical Problems Russia Sandra Haeuplik-Meusburger Technical University of Vienna(TU Wien) Austria Anna Chernikova Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Robert Hinshaw USA Alexander Choukér Medical university of Munich Germany Jan Hoenemann Universitätsklinikum Köln Germany Gilles Clement National Aeronautics and Space Administration(NASA) USA Uwe Hoff mann German Sport University Cologne Germany Jean-Michel Contant Astronautics International Academy of Astronautics France Xue Huifeng China Francis A. Cucinotta University of Nevada, Las Vegas USA Eugene ilyin Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Chloё De Laet France V.K. Ilyin Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Artem Demin Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Vyacheslav Ilyin Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Riccardo Di Roberto Olga .A. Ivanova Russia Mikhail Dobynde University of Pennsylvania Russia Michael Jenkin York University Canada Meghan Downs National Aeronautics and Space Administration(NASA) USA Abhishek Jha Department of Space, Indian Space Research Organisation Indian Alexander Ivanovich Dyachenko Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Steven Jillings UAntwerpen Netherlands Alexandra Dymova Russia Peter Anto Johnson University of Alberta Canada Robin S. Elgart University of California San Francisco(UCSF) USA Laura Kalinski Grigori Enikolopov Stony Brook Medicine USA Nick Kanas University of California San Francisco(UCSF) USA 42 43

SPEAKERS SPEAKERS

Name Surname Organization Country Name Surname Organization Country Daria Kashirina Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Danil Maklakov The National Research University «Belgorod State University» (BelSU) Russia Daria Kashirina Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Olga Manko Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Shaban associate professor Liliy Marchenko Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia opthalmology Bolan University Khan Bolan University of medical and health sciences Quetta Baluchistan Pakistan of medical and health sciences Andrei Markin Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Quetta Baluchistan Braun Markus German Space Agency(DLR) Germany Abhijeet Kibe Department of Space, Indian Space Research Organisation Indian Andrey Martusevich Privolzhsky Research Medical University Russia Camilla Kienast Center for Space Medicine Germany Jancy C. Mcphee, National Aeronautics and Space Administration(NASA) USA Vyacheslav Klimentov Memorial Museum of Cosmonautics Russia Alexander Medenkov Russia Peter Kolosov Institute of Higher Nervous Activity Neurophysiology RAS Russia Alexandr Meigal PETRSU Russia Margarita Komarova Russia Valerii Gennadevich Mitkovskii FGBUZ CKBVL FMBA Rossii Russia Jessica Koschate Carl von Ossietzky Universität Oldenburg Germany Fabian Möller Deutsche Sporthochschule Köln Denmark Anna Kovaleva Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia M. Mortreux Nina Kozlova Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Evgeny Aleksandrovich Krasavin The Joint Institute for Nuclear Research Russia Evgeniia Motanova Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Margarita Olegovna Kriuchkova G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms RAS Russia Christian Mühl German Aerospace Center Denmark Vladislav Kukanov Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Erika Muratov German Space Agency(DLR) Germany V Kulikov Russia A.A. Naumova Russia Valeriy Kupriyanov North-West Interregional Public Organization Federation of Cosmonautics of Russia Russia Tatiana Nemirovskaya Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Andrey Kuritsyn Yuri Gagarin Cosmonaut Training Center (GCTC) Russia Igor Nichiporuk Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Anna kussmaul Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Alexandra Noppe German Space Agency(DLR) Germany Irina Kutina Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Irina Vladimirovna Ogneva Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Olga Kutko Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Oliver Opatz charite Germany Dmitriy Kuzichkin Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Oleg Igorevich Orlov Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Floris L L Wuyts University of Antwerp The Netherlands Evgeniya Orlova Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Naima Laharnar France José María Ortega-Hernández Christian Lardier France Nikolay Osetsky Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Pavel Lashukov Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Pamila Osipova Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Svetlana Alekseevna Lebedeva Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Mikhail Ostrovsky Emanuel Institute of Biochemical Physics RAS Russia Leopold Lecheler German Space Agency(DLR) Germany Dmitrii Sergeevich Ozerov Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Igor Petrovich Levchuk Pirogov Medical University Russia Anna Pakhomova Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Margarita Aleksandrovna Levinskikh Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia I.I. Paramonova Russia Yannick Lichterfeld German Space Agency(DLR) Germany Konstantin Parshin Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia M.-T. Linossier Zarana Patel National Aeronautics and Space Administration(NASA) USA Stéphanie Lizy-Destrez Institut Supérieur de l’Aéronautique et de l’Espace France Elena Sergeevna Luchitskaia Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Stanislav Pekov Skolkovo Institute of Science and Technology Russia I.D. Lvova Russia Oleg Perevedentsev Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Nataliya Lysova Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia A.A. Perevezentsev Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Anna Martina Maggioni Charité Universitätsmedizin Berlin Germany Laura Peuriere Martina Anna Maggioni Charité – Universitätsmedizin Berlin Germany Sarah Piechowski German Aerospace Center Germany Igor Makarov Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Rene Pischel 44 45

SPEAKERS SPEAKERS

Name Surname Organization Country Name Surname Organization Country Dmitry Podyanov The main Military Clinical Hospital named after Academician N. N. Burdenko (GKVD) Russia Yuriy Smirnov Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Inga Poletaeva Russia M.B. Smith Bubble Technology Industries Inc. Canada Sergey Ponomarev Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Alexander Smoleevskiy Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Daniil Popov Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Zoya Solovieva Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Julia Popova Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Vladimir Solovyov Russia Olga Popova Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Alex Stahn University of Pennsylvania USA George Profi tiliotis Alex Stahn Perelman School of Medicine USA Vladimir Proshkin Research and Design Institute of Chemical Engineering, Joint-Stock Company (JSC «NIIchimmash») Russia Katrin Maria Stang German Space Agency(DLR) Germany I.E. Rabichev Russia Michael B. Stenger National Aeronautics and Space Administration(NASA) USA PM Ravishankar Indian Space Research Organisation India Claudia Stern German Space Agency(DLR) Germany Carlo Reggiani The University of Pavia Italy Mr. Lionel (CNES) Suchet France Millard Reschke National Aeronautics and Space Administration(NASA) USA Sukonkina Sukonkina Russia Katerina Bernardova Sykorova SEZNAM Czech Petra Rettberg German Space Agency(DLR) Germany P. Tefelnerova Russia Christian Rogon German Space Agency(DLR) Germany Leonid Tereshchenko Russia P.V. Romanov Dr.Wang Tianyi China Susanna Rosi University of California San Francisco(UCSF) USA Elena Tomilovskaya Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Ivan Rozanov Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Elena Tomilovskaya Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia S. Rozhkov Russia Roberto Toscano Università Degli Studi Roma Tre Italy Lea Christiane Rundfeldt Institut für Physiologie Germany Yu.V Ukraintseva Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences Russia V. Rusanov Russia Pavel Umriukhin I.M. Sechenov First Moscow State Medical University Russia Aleksey Salnikov Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Mariya Usik Russia Jordi Sandalinas Open University of Catalonia (UOCuniversitat) Spain Angelique Van Ombergen European Space Agency (ESA) Alina Saveko Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Ivan Vasilev Medical and Technological Center of Bauman Moscow State Technical University Russia Alexandra Savinkina Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Andrey Vasin Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Anantaram Savit Indian Space Research Organisation India Laurence Vico Université Jean Monnet France Darya Schastlivtseva Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia I.M. Vikhlyantsev Russia Catho Schoenmaekers The University of Antwerp(UAntwerpen) Belgium Natalia A Vilchinskaya Kathryn Maren Schroeder The President and Fellows of Harvard College Alla Vinokhodova Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Kiril Shef Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Pavel Vlasov Gagarin Research&Test Cosmonaut Training Center Russia Mark Shelhamer Johns Hopkins University USA Melanie von der Wiesche Institute of Aerospace Medicine Germany Boris Shenkman Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Janice Waldvogel Germany Tatiana A. Shigueva Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Alexandra Whitmire National Aeronautics and Space Administration USA Nikita Shishkin Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Amanda Winters Andrey S. Shtemberg Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Andy Wyrobek Lawrence Berkeley National Laboratory USA Vyacheslav Shurshakov Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Usef Dghamalovich Yakhya Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Dmitry Shved Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Anna Yusupova Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia F.M Shvetsky Russia Nadezhda Zakharova Institute of Cell Biophysics, RAS Russia Katharina Siems German Aerospace Center Germany Inna Zelenskaya Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Russia Vladimir Skorkin Institute for Nuclear Research of the Russian Academy of Sciences Russia Marina Zueva Helmholtz Medical Research Center of Eye Diseases Russia 46 47

MEDIA PARTNERS Notes

General Partner

Information Partners 48 49

Notes Notes 50 51

Notes Notes 52 53

Notes Notes 54 55

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Notes Notes